Gene PTC6
PTC6
Species: S.cerevisiae
Alias: PTC6
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTC6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PTC6.AA | PP2Cc | 13-409 | 16 | 1.2e-51 | 178.77 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 13-409 Range on HMM: 1-338/338 Sequence Identity: 16% (73 aa) SQNVGLKLDLLRGLPGYVGHATSRINRLENQDNYSIKMMRSWPNAYGSALNCSVFDGHGEKGAQLSQLLADKLCSSLDFPEPSWDKQDLKKLVQEYARRF . .|..... |. .. . .| ...| .... . |||||| | . .| ....|.. |. ..... .|.|.. | .. . HS-MGYNSGWRYGY----MESSMQGWRHPMEDAHVCRP------------FFGVFDGHG--GHECAQYCRKHLHEHLAEELQFHKDDDYKEND-E-MQ-D PEGNYWKHKLSTFEKFYNKFIKNCNSKQELLLMKEGDSAILGQNGGRMIFDKMGNIIDKIALLTELDRLRLFYGFARFDLDQCCGLGTAAGSTASSIFLY |. |.. . .. ... |........| | .. . .||. ... -EP-------------------------------EMW-W-R-MW-HDKWFEDWEDALRKAFLRMDEEI-----------------------CTAVVALIR PYDDPNAPIDEGKDDDSWIISHSGLLKLIVTQVGDSKIILCDQDG---------IAHALTTTHHINSSRERHRLSIDPS-----RLDPDAFGET---RFL . . |.| .|||| ..|| ... ||.||. |. . ..|| |.. .. .... |.. GNK------------------------LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMPMHRQWVMNWNCDVWRVN NN---FANTRSFGDVAGKPYGISSEPDIF------------SFLVGNTLHLPRSERSKLPF----NGDECFLALVTDGITNKLADQEVVDLITSTVNSWG .. | .|.|||. | .. | .|. .|. .| . .| . . | .|| | .||..... .|||||..... ..|. GVPIPLAVSRAFGDHYYKW-KED-E-KIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQEVVDIVRKCLRKWH LK-----------------KATPQFVAEETIKFIQAIATKHSDNATCVVV | |.... . .. .|| .|| |..|| HKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----CDNMTVIVV |
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| Phosphatase | PTC6.AA | PP2C | 108-402 | 18 | 2.4e-64 | 224.89 | Pfam | 1-284 (284) | Show / Hide |
Range on Protein: 108-402 Range on HMM: 1-284/284 Sequence Identity: 18% (57 aa) YARRFPEGNYWKHKLSTFEKFYNKFIKNCNSKQELLLMKEGDSAILGQNGGRMIFDKMGNIIDKIALLTELDRLRLFYGFARFDLDQCCGLGTAAGSTAS .. |.....|.|... . .|... .. . .... |. .. ||... ........|. . | |.. ..|.. ..|..|.. ......|.. WDYGFCRMQGWRHFMEDAHHCYPNMNCS-----SSGKDSWHFFAVFDGHGGHQAAKYCRKHLHKA-MNTILKERKSFPEGNPKDVEQALRKSFLECDTDM SIFLYPYDDPN----APIDEGKDDDSWIISHSGLLKLIVTQVGDSKIILCDQDGIA---HALTTTHHINSSRERHRLSIDPSRLDPDAFGETRFLNN-FA . ..|... | .....| .. ...|... . .|.| ..||| ..||...... |.||. |. .. .||.|.. ..... |..|. . .| MFYSAPWHEQNVMHWECWHSGCTAVCAYIRNQKN-ILYVANCGDSRAVLCRNGNAHNWVHQLTYDHKPSNEDERRRIRQAGGWVMWW--GFWRVNGVWLA NTRSFGDVAGKPYGISSEPDIFSFLVGNTLHLPRSERSKLPFNGD-ECFLALVTDGITNKLADQEVVDLITSTVNSWGLKKATPQFVAEETIKFIQAIAT ..|.|||. ||. .. .. . | . .. ... | ..|| | .||..... ||||.|.. .....|. .|. ..|..... .| .. VSRAFGDFHYKPNHTC------FPKEQPVTAEPDIT-PEHKITPDHDEFLILACDGLWDVMSDQEVCDIVRQCRSDWN----DPMEACEKLVDYCIAYGS KHSD ... EDNI |
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| Phosphatase | PTC6.AA | Group.PPM.PD | 27-413 | 19 | 3.3e-46 | 147.6 | In-house | 37-323 (459) | Show / Hide |
Range on Protein: 27-413 Range on HMM: 37-323/459 Sequence Identity: 19% (71 aa) PGYVGHATSRINRLENQDNYSIKMMRSWPNaygsALnCSVFDGHGekGAQLSQLLADKLCSSLDFPEPSWDKQDLKKLVQEYARRF-PEGNYWKHKLSTF . .|.|... .| |..|...| .. . .. ..|||||| ||. ... |.|| . | ....... || .. .. . .. ||.| .. glrygvasmqgwrkemEDrhvivenfdnnd----sf-fgVfDGHg--GaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsaf EKFYNKFIKNCNSKQelllmkegdsailgqnggrmifdkmgniidkiallteldrlrlfygfarfdldqccGLGTAAGSTASSIFLYpyddpnapidegk ... ...|.|. ..| .|.|| ....||.| .|||...|| . leldedlseeaneke--------------------------------------------------------epgkdsGtTAvvalin------------- dddswiishsglL-KLIVTQVGDSKIILCdQDGIAHALTTTHHINSSRERHRLSIDPSRLDP-DafgetRFLNNFANTRSFGDVAGKPyG---ISSEPDI .| |..|.. |. .. .||.|. .. . . | .. | .|..||.. | ..|.|||. .. . .. || | .|| ------------gkklyvANaGDSravLc-rngkavplskdHkpenpeEreRIekagGsveidg-----RvnGilavsRalGdhdlkk-eeqmvsaePdv FSFLVGntlhlprsersklpfnGDECFLALVTDGITNKLADQEVVDLITSTVNS-----WGLKKATPQFVAEETIKF-IQaIATKHSDNATCVVVRLSN . . | ..|||... .|... ... . ...|... . . .. ||.|..||.|.. svvklt----------------eedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakgst-gdgtscDNiTvivvtlnd |
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| Phosphatase | PTC6.AA | Family.PPM.PD | 30-436 | 19 | 1.5e-40 | 128.9 | In-house | 17-308 (495) | Show / Hide |
Range on Protein: 30-436
Range on HMM: 17-308/495
Sequence Identity: 19% (77 aa)
VGHATSRINRLENQDNYSIkmMRSWPNAYgSALNCSVFDGHGekGAQLSQLLADKLCSSLDFPEPSWDKQDLKKLVQEYArrfpeGNYWKHKLSTFEKFY
.| |... .| |..|.... . .. | . ..|||||| ||. ... |.||.. | . . |... .. .. | .. . ..|..
ygvasmqgwrsemeDahvv--venlenne-dfslfgvfDGhg--Gaeaaefaakklhkilkkqlekkddeksstsaessa-----ekvkealrkafleld
NKFIKNCNSKQelllmkegdsailgqnggrmifdkmgniidkiallteldrlrlfygfarfdldqccgLGTAAGSTASSIFLYPYDdpnapidegkddds
... ...|.|. .| .|.|| .... . .|.| ..|||...||
eelseelneks---------------------------------------------------------agkdsGtTAvvvlirgkk--------------
wiishsgllkLIVTQVGDSKIILCdQDGIAHALTTTHHINSSRERHRLSIDPSRLDPdafGETRFLNNFANTRSFGDVAGKP---YGISSEPDIfsflvg
..| |..|.. |. .. .||.|.. ... ...|. . | .|..||.. |. ...|.|||| .... ... . ||
----------lyvAnaGDsravLc-rngkavelskdHkpenpeEreRIekagGkvvi---rdgrvnGvlavsRalGdfdlkkeeqaivsaePdi------
ntlhlprserSKLPFNGD-ECFLALVTDGITNKLADQEVVDLITSTVnswGLKKATPQFVAEETIKFIqaIATKHSDNATCVVVRLSNwgnWPNVDRTGP
|..||. . | ..|||.|. .|. |..... .||| .. . .| ...||.|..|||.. ..... .....||. .|
----------tsvkltqeedeflvlasdGlWdvlsneevvelvretl---eekeedleeiaeeLvdea--lakgsrDNiTvlvvalye---nikqqnrfv
QRETKLMNAQS
lnknslmtrrs
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| Phosphatase | PTC6.AA | Subfamily.PPM1K.PD | 239-410 | 31 | 1.3e-18 | 57.0 | In-house | 118-263 (264) | Show / Hide |
Range on Protein: 239-410 Range on HMM: 118-263/264 Sequence Identity: 31% (49 aa) KLIVTQVGDSKIILCdQDGIAHALTTTHHINSSRERHRLSIDPSRLDPDAFGETRFLNNFANTRSFGDVAGKPYGISSEPDIFSFLVgntlhlPRsersk .|.....|||. ||| ..| |. ||. |. . |..|. ... .. |. . .| |||.||. |.||. ..|. |. |....|| |.|||| elvlaslGdsrailc-rnGkakkltkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrslGdldlkryGviatPetkslkv------kh----- lpfnGDECFLALVTDGITNKLADQEVVDLITSTVNSwglkKATPQFVAEetikfiQAIATKHSDNATCVVVR .. ...||. ||.. . . . ..|.| ||. ||||.||| ----aadsflvlitdgisfvvnsqelcdlvrlchdp----eeaahavte------qalqygsednatavvvp |
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| Phosphatase | PTC6.AA | Subfamily.LRR-PP2C.PD | 239-372 | 28 | 1.2e-12 | 37.5 | In-house | 112-228 (257) | Show / Hide |
Range on Protein: 239-372 Range on HMM: 112-228/257 Sequence Identity: 28% (33 aa) KLIVTQVGDSKIILCDQDGIAHALTTTHHINSSRERHRLSIDPSRLDPDaFGETRFLNNFANTRSFGDVAGKPYGIsSEPDIFSflvgntlhlprsersK | ... ||||...||..||.|. |. |. . .|..|.| . . .| ..| .|..||. .|. . ..||. ..| .. || | | kvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvst-vvtsrvnGtlavsralGdsflePfvv-pdPdlsq---------------s LPFNGDECFLALVTDGITNKLADQEVVDLITSTV || . ..|.| |... . leiskkdkflilacdGiwdlisdeeaveivagis |
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| Phosphatase | PTC6.AA | Subfamily.PPM1E.PD | 239-410 | 28 | 1.1e-11 | 34.4 | In-house | 122-268 (269) | Show / Hide |
Range on Protein: 239-410 Range on HMM: 122-268/269 Sequence Identity: 28% (44 aa) KLIVTQVGDSKIILCDqDGIAHALTTTHHINSSRERHRLSIDPSRLDpdAFGETRFLNNFANTRSFGDVAGKPYgISSEPDIfsflvgntlhlprserSK .| |. .|||. .|. .| | |. |. . .|..|. . .|. | . . .|. ||| ||| .|.|.|..... .|.| .| | .|| qlyvaWlGDsqallvr-kgeavqlmkpHkPeredEkkRieeagGlvv--vigawRvnGvLsvsRaiGDvklkpy-vsgeadv----------------ae LPFNGDECFLALVTDGITNKLADQEVVDLITSTVNSwglKKATPQFVAEETIKfiQAIATKHSDNATCVVVR . . . ..|||.|... ... .. . . ||.. .. .|. ||| | ||| veldgsedylilacDGlwDvvneeevvklveeflad---gaedlsevakllve--aakeagssDnitvvvvf |
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| Phosphatase | PTC6.AA | Subfamily.PPM1A.PD | 238-432 | 22 | 1.9e-11 | 33.5 | In-house | 125-296 (309) | Show / Hide |
Range on Protein: 238-432 Range on HMM: 125-296/309 Sequence Identity: 22% (42 aa) LKLIVTQVGDSKIILCDQdGIAHALTTTHHINSSRERHRLSIDPSrldpdAFGETRFLNNFANTRSFGDVAGKPYgisSEPDIFSFLVgntlhLPRSERS ||.....|||...|. . | .. |. |. . .|..|.. | . | .|..|| | .| . . ||| .| . . . kklylancGDsRavlsrn-gkvvfateDHkpsdpkEkeRienAgG-----svmikRvnGsLAvsRalGDydykek---pekkateqlv-----spepevt KLPFNGDECFLALVTDGITNKLADQEVVDLITSTVNSwglkKATPQFVAEETIKfiQAIATKHSDNATCVVVRLSNwgnWPNVDRTGPQRETKLM . || | .||| . ..||.....|... .. .. ||.| .. ... || ....| |.. |.|.. ..|..| vierdeedeflvlacDGiwDvmsneevaefvksrlev----tddleevanelld--tcLekgsrDNmsvilvllpg---apkvseeaikkekeld |
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| Phosphatase | PTC6.AA | Subfamily.PPM1L.PD | 239-409 | 26 | 6.9e-10 | 28.6 | In-house | 126-271 (273) | Show / Hide |
Range on Protein: 239-409
Range on HMM: 126-271/273
Sequence Identity: 26% (45 aa)
KLIVTQVGDSKIILCDQDGIAHALTTTHHINSSRERHRLSIDPSRLdpDAFGETRFLNNFANTRSFGDVAGKPYGI-SSEPDIFSFLVGNtlHLPRsers
.|||..||||. .|.|..|.| |. |. . .||.|. . | | .| .|..|| | . ..|||..| . .| |.
dlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfi--afrGvwrvaGvlatsralGdyplkdknlviadpdiltfdldd--hkpe----
klpfngdecFLALVTDGITNKLADQEVVDLITSTVNswglkkaTPQFVAEETIkfIQAIATKHSDNATCVVV
|| | .||. . ....| | | .. |.| | . ... || | .||
---------flilasdGlwdtfsneeavrfikerlk-------epdfGakslv--lesfkrGsvdnitvlvv
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| Phosphatase | PTC6.AA | Subfamily.PPM1G2.PD | 239-409 | 28 | 2.2e-09 | 26.7 | In-house | 119-275 (275) | Show / Hide |
Range on Protein: 239-409
Range on HMM: 119-275/275
Sequence Identity: 28% (49 aa)
KLIVTQVGDSKIILCDQDGiAHALTTTHHINSSRERHRLSIDPSRLDpdafgETRFLNNFANTRSFGDVAGKPYG-ISSEPDIfsflVgnTlHLPRSERS
||.|. .|||. .|. . ..||. | .. |..|. . | .| | |..|| . | ...| .| || .| . .||
klyvanaGDsravlsskgn-vkalsfDhkPqeesekkriiaagGfve-----lnrvngnLalsralgDfefkknvkkkpeeqi----v--t-avPDvlvk
KLPfnGDECFLALVTDGITNKLADQEVVDLITSTVNSwglkKATPQFVAEETIKFIQA----IATKHSDNATCVVV
|. || | ||| . | ..|||||. . . | .|... ..|| .. | . || |.|.|
kld--eddeflvLaCDGiWDvltnkevvdlvrerlvs----gakldeiieelldkclapdssntgvGcDnmtvviv
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| Phosphatase | PTC6.AA | Subfamily.TAB1.PD | 239-375 | 29 | 1.3e-08 | 24.0 | In-house | 150-283 (336) | Show / Hide |
Range on Protein: 239-375 Range on HMM: 150-283/336 Sequence Identity: 29% (40 aa) KLIVTQVGDSKIILCDQD--G-IAHALTTTHHINSSRERHRLSidPSRLDPDAFGETRFLNNFANTRSFGDVAGKpyGISSEPDIFSFLVGN-TLHLPRS || | ||||. ||.... | ... | | . | .||. ||.. . . | .. .||| || | . | |..| |.. | . kLyvaNvGdsrAilvesekdgikvkQLsvdHnvdNedElkRlk--dLGldieqikqnkrlgskeaTRsiGdykik--kgykevdvlssAkgePiiatPdi ErSKLPFNGDECFLALVTDGITNKLadQEVVDLITSTVNSW .. |. | || |. ||. . | |. . |. |. n-gpkdindlegfllLmSdGlykal--ieltnpptadvsla |
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| Phosphatase | PTC6.AA | Subfamily.PDP.PD | 238-387 | 20 | 1.4e-08 | 24.3 | In-house | 177-344 (409) | Show / Hide |
Range on Protein: 238-387 Range on HMM: 177-344/409 Sequence Identity: 20% (34 aa) LKLIVTQVGDSKIILCDQDGIA----HALTTTHHINSSRERHRLSID-PSRLDPDAFGETRFLNNFANTRSFGDVAGKP-YGISSEP--DIF--SFLVGN .| | ..||.. .|. |.. . .|.. . .. .| .|. . |. . . | | . | .| |||| | .... ..... ... .. telhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLaPlRAFGdvryKwskelqkkvlekllevkvvepk TLHLP-----RSERSKLPFNGDECFLALVTDGITNKLADQEVVDLITSTVNSWG---LKKATPQFVAE | . | . ... .. || | |||. . | ..|||.|.. ... . ..|.|. . . dyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkknkakvaaepaklkk |
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| Phosphatase | PTC6.AA | Subfamily.PPM1G.PD | 239-376 | 29 | 1e-06 | 18.0 | In-house | 320-444 (482) | Show / Hide |
Range on Protein: 239-376 Range on HMM: 320-444/482 Sequence Identity: 29% (38 aa) KLIVTQVGDSKIILCDqDGIAHALTTTHHINSSRERHRLSIDPSRLDPDAfgetRFLNNFANTRSFGDVAGKPY-GISSEPDIFSflvgntlHLPRSERS |||| .|||. .|. .| | | | . |..|. ... | | | .|| | | . | . ||| | . .. klivanaGDsRcvlsr-nGkaldlsiDhkPeDeveleRiekaGGkvtldg----RvnGGLnlsRalGDhaYktneeLpaeeqmis-------alPDikkl KLpfNGDECFLALVTDGITNKLADQEVVDLITSTVNSWG || | .||| | . ||||| ... .. il--teedeFlvlacDGiWnvmssqevvdFvraklkese |
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| Phosphatase | PTC6.AA | Subfamily.ILKAP.PD | 240-377 | 25 | 1.8e-06 | 17.3 | In-house | 131-257 (298) | Show / Hide |
Range on Protein: 240-377 Range on HMM: 131-257/298 Sequence Identity: 25% (34 aa) LIVTQVGDSKIILCDQDGIAH----------ALTTTHHINSSRERHRLSIDPSRLdpdafGETRFLNNFANTRSFGDVAGKPYGISSEPDIfsflvgntl | |. .||||..|. .. .. |. |. | ||.|. . . . | | .. ||.|| | |..|.||... .| | lyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaGgvv-----rdgRvlGvlevsRsiGDgrfkelgvistPdv--------- hlprsERSKLPFNgdECFLALVTDGITNKLADQEVVDLITSTVNSWGL . |. | ||. ... .|||. |...... -----kkceLten--DlfvvlaCDGLwkvfeadevvkfilkvlededd |
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