Gene PTC7
PTC7
Species: S.cerevisiae
Alias: PTC7
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of PTC7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | PTC7.AA | Subfamily.PPTC7.PD | 66-342 | 46 | 2.6e-107 | 348.3 | In-house | 2-263 (263) | Show / Hide |
Range on Protein: 66-342 Range on HMM: 2-263/263 Sequence Identity: 46% (130 aa) AFQPKDRDDLIYQKLKdsIRSPTGEDNYFVTSNNVHDIFaGVADGVGGWAEHGYDSSAISRELCKKMDEISTalaenSSKETLLTPKKIIGAAYAKIRDE . ......||..||.| ||..|||.|||.||.|.|.. |||||||||.|.|.|.|..|.||.||...|.. .||.. .||||.|||.....|| svvcgfakdllkqksk--krskfGeDayFvssnkvadvl-gVADgvggwreygidpsefskelmkkcerivk-----eskfkerkpkkileaayqellee KVVKVGGTTAIVAHFPSNG-KLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEmlkeaerRGSKYILNTPRDADEYSFQLKKKDIIILAT |..||..||......... |||.||||||.. |.|..|.|...|.|.. ||.||||||.||| |..|.||..|..||..||..||.|.|.|||| kvpvvGsstacivvldredkklesaNlGDSgflVvRngkvvhrskeqqhyFNtPyqLsipPee-------rdgkvildkpeaadstsfevkkgDlillat DGVTDNIATDDIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDPNYPSVFAQEiSKLTGKNYSGGKEDDITVVVVRV ||.||...|.|. .||....|...|||||..........||.||.| |.||.. .| .|...||||.||||||...| DGvfDNlsedeilevlkelkerdeeelqllanslaekarelsldpkyespFakk-akknglaasGGKpDDitvvlalv |
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| Phosphatase | PTC7.AA | Family.PPTC7.PD | 67-342 | 48 | 1.8e-109 | 355.4 | In-house | 2-262 (262) | Show / Hide |
Range on Protein: 67-342 Range on HMM: 2-262/262 Sequence Identity: 48% (134 aa) FQPKDRDDLIYQKLKdsIRSPTGEDNYFVTSNNVHDIFaGVADGVGGWAEHGYDSSAISRELCKKMDEISTalaenSSKETLLTPKKIIGAAYAKIRDEK ......||..||.| ||..|||.|||.||.|.|.. |||||||||.|.|.||||.|.||.||..... .||.. |.|||.. ||||....||| vkcgfakdllkqksk--krskfGeDayFvssnkvadvl-gvADgvggwreygvdssafsselmkkcerlvk-----eskfkplkpkkllkaayaelleek VVKVGGTTAIVAHF-PSNGKLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEmlkeaerRGSKYILNTPRDADEYSFQLKKKDIIILATD ..||..||.|... ... |||.||||||.. |.|..|.|...|.|.. ||.||||||.||| |..|.| ..|..||..||..||.|||.||||| vpvvGsstAcvvvldredkklesanlGDsgflvvRegkvvhrskeqqhyFntPyqLsipPee-------rdgkvisdspeaAdstsfevkkgDiillatD GVTDNIATDDIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDPNYPSVFAQEiSKLTGKNYSGGKEDDITVVVVRV |.||...|.|. .||....|...|||||..........||.||.|.|.|||. .|..|...||||.||||||...| GvfDnlsedqileelkelkerdeeelqllanslaekareLsfdpkyespFaqk-akkrglaasGGKpDDitvvlavv |
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| Phosphatase | PTC7.AA | PP2C_SIG | 71-342 | 16 | 2.5e-53 | 184.4 | SMART | 1-250 (250) | Show / Hide |
Range on Protein: 71-342 Range on HMM: 1-250/250 Sequence Identity: 16% (49 aa) DRDDLIYQKLKDSIR-SPTGEDNYFVTSNNVH--DIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAAYAKIRDEKV |....||| .|... . |.|... .. . .| ..|..| || ||. ..... .....|...... . ........|.. ... DDHWDIYQYYEDATQVC---GDWYDFWKIPEGQDRYFFVIGDVMG-WA-HGLPAALMMGMARTMMRTFWHE-------SPPQILERCNRWIYQN---NHE VKVGGTTAIVAHF---PSNGKLEVANLGDSWCGVFR--DSKLVFQTKF-------------------QTVGFNAPYQLSIIPEEMLKEAERRGSKYILNT .. .||...... .....|.... |.|.. ..| |...|..|. ...... . | ..|. | ECGMFTTMCCCVYMPDFATHTLWYCHCGHSPPYLYRAMDGGRVEHTHDHYLVQHYVMRIIDEEDAKHHPWHNWTGPPLGMEPDYM--------------- PRDADEYSFQLKKKDIIILATDGVTDN-------IATDDIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDPNYPSVFAQEISKLTGKNYSGGKEDDIT .|. .||... |.....|||||.. .. ..... |... ... | ..|...... ....|.|. .||.| ---YDVQEFQYEPGDRFVMCTDGVTEARNPQGEFFGEEWLQEILEEHQ---CCCPQEIAQRIMQELMEHMGDHNG--------------------HDDMT VVVVRV |.||.| VIVVKV |
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| Phosphatase | PTC7.AA | PP2Cc | 68-340 | 13 | 1.3e-33 | 118.92 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 68-340
Range on HMM: 1-338/338
Sequence Identity: 13% (49 aa)
QPKDRDDLIYQKLK--DSI--RSPTGEDNYFVTSNNVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKE-----------------
.. . ..... . .|. . ..|| .... | ||.|| || ..... ..|.. |. .. . .
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP------FFGVFDG------HG--GHECAQYCRKHLHEHLAEELQFHKDDDYKENDEMQDEPEMWWR
-----TLLTPKKIIGAAYAKIRDEKVVKVGGTTAIVAHFPSNGKLEVANLGDSWCGVFRDSK----------LVFQTKFQTV-------------G----
... ..... |. .. .| .||.||.. | | |||.|||.. ..|... ... |. ... |
MWHDKWFEDWEDALRKAFLRMDEEI------CTAVVALIRGNK-LYVANVGDSRAVLCRNGNDNWWGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMP
----FNAPYQL---SIIPE---EMLKEAERRGS--------------------------KYILNTPRDADEYSFQ----LKKKDIIILATDGVTDNIATD
. ... . . .. | . |. ..| . | .. | .||..||..|.. .
MHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAEPDVTHHELWQMTVPTPDDDFLILCCDGLWDVMSNQ
DIELFLKDNAARTNDELQLLSQKFVDNVVSLS----KDPNYPSVFAQEISKLTGKNYSGGKEDDITVVVV
.. ..... ..... ....|..... . . | | |. |... .. .|..||.||
EVVDIVRKCLRKWHHK-PVKNQAQENA-H-MMRHRQKKHNDPMEAAKRLCDCAI-------CDNMTVIVV
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| Phosphatase | PTC7.AA | Group.PPM.PD | 85-209 | 25 | 2.6e-16 | 49.2 | In-house | 48-187 (459) | Show / Hide |
Range on Protein: 85-209 Range on HMM: 48-187/459 Sequence Identity: 25% (35 aa) RSPTGEDNYFVTSNNVHD-IFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAE-------------NSSKETLLTPKKIIGAAYAKIRDEKV--V . . ||......| .. | || || ||.. . .. ... | |.. . .. ... .. |. | . . . ... . ..||.| . wrkemEDrhvivenfdnndsffgVfDGHgGaeaaefaakkLpkilkkqlkkkkdevskksaeasldnddrgekvkkalrsafleldedlseeanekeepg KVGGTTAIVAHFpSNGKLEVANLGDSWCGVFRDSKLVFQTK ||||.||.. ...|| |||.||| . . |. | | .| kdsGtTAvvali-ngkklyvANaGDSravLcrngkavplsk |
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| Phosphatase | PTC7.AA | SpoIIE | 99-343 | 15 | 7.7e-16 | 51.89 | Pfam | 1-204 (204) | Show / Hide |
Range on Protein: 99-343
Range on HMM: 1-204/204
Sequence Identity: 15% (40 aa)
NVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAAYAKI----RDEKVVKVGGTTAIVAH-FPSNGKLEVANLGD
. . ... ..|..| || ...|.. .|. . .. .. .. | .. .. . .|. . ..|...|. |. |....|| |
PDGRWALVIGDVMG----HGVPAAATMMMLRTMLRTLAHHGLD---------PAEVLHRLNRAMYRNLEDD----EMFATCCYAVYDPDTGHCRYANAGH
SWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLKEAERRGSKYILNTPRDADEYSFQLKKKDIIILATDGVTDNIA-TDDIELFLKDNAA--RTND-
. ..|.. .. | . ..|..| ..|. . ....|.|.. |...| |||||.. . | |.| ... . .. .
PPPLLWRPDG---GVWFLL-PPGPPLGLGMLPD------------------WPYPTHEFPLPPGDTLVLYTDGVTEARGHDPDGEMFGEERLLCRQLLRE
---E----LQLLSQKFVDNVVSLSKDPNYPSVFAQEISKLTGKNYSGGKEDDITVVVVRVD
.. | . ... | . . . .| .||.|..|.|..
HCRHGLPPPEELCDAIMEDVLRFH-----------------D-HGDGHPHDDMTLLVIRWR
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| Phosphatase | PTC7.AA | Group.PPM.PD | 250-342 | 18 | 1e-10 | 30.8 | In-house | 242-321 (459) | Show / Hide |
Range on Protein: 250-342 Range on HMM: 242-321/459 Sequence Identity: 18% (18 aa) YSFQLKKKD-IIILATDGVTDNIATDDIELFLKDNAAR----TNDELQLLSQKFVDNVVSLSkdpnypsvfaqeiskltgKNYSGGKEDDITVVVVRV ...|...| ..||.||. | . ... |.... . . .|. ... ||. .. . ....|.. |.|||.||.. svvklteedeflvlAsDGlWdvlsneevvefvretlekkkkelkkdleeiaerlvdealakg------------------stgdgtscDNiTvivvtl |
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| Phosphatase | PTC7.AA | Family.PPM.PD | 87-209 | 26 | 1.4e-09 | 26.9 | In-house | 28-159 (495) | Show / Hide |
Range on Protein: 87-209 Range on HMM: 28-159/495 Sequence Identity: 26% (36 aa) PTgEDNYFVTSNNVH--DI-FAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAAYAKI-------RDEKV-VKVGGTTA . ||...| .| . |. . || || || . . .. . . | |. .. .... ..|.... |... |. .. ..|| .| .|||| em-eDahvvvenlennedfslfgvfDGhgGaeaaefaakklhkilkkqlekkddeksstsaessaekvkealrkafleldeelseelneksagkdsGtTA IVAHFpSNGKLEVANLGDSWCGVFRDSKLVFQTK .|.. ...|| |||.||| . ..|. | | .| vvvli-rgkklyvAnaGDsravLcrngkavelsk |
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| Phosphatase | PTC7.AA | Subfamily.PPM1L.PD | 90-202 | 26 | 2.2e-09 | 27.1 | In-house | 27-142 (273) | Show / Hide |
Range on Protein: 90-202 Range on HMM: 27-142/273 Sequence Identity: 26% (31 aa) EDNYFVT---SNNVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENS--SKETLLTpKKIIGAAYAKIRDEKV-VKVGGTTAIVAHFpSN || . .. .|... | .| || || . . ..... .|. |. .. .. . ..||| ..|. . . . |. .. ||||..| .. edrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentvpinfskllt-deilsvdekllekakraediaGttalialv-qe GKLEVANLGDSWcGVFRDS .| |||.||| ||. | sdlivanvGdsr-Gvlydk |
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| Phosphatase | PTC7.AA | Family.PPM.PD | 251-342 | 17 | 1.5e-08 | 23.5 | In-house | 217-286 (495) | Show / Hide |
Range on Protein: 251-342 Range on HMM: 217-286/495 Sequence Identity: 17% (16 aa) SFQLK--KKDIIILATDGVTDNIATDDIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDpnypsvfaqeiskltgknysggkeDDITVVVVRV |..|. ... ..||.||. | . ... ..... . . .|. .... ||.... |.|||.|| . svkltqeedeflvlasdGlWdvlsneevvelvretleekeedleeiaeeLvdealakgsr------------------------DNiTvlvval |
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| Phosphatase | PTC7.AA | Subfamily.PPM1E.PD | 246-302 | 22 | 6.1e-07 | 18.8 | In-house | 196-253 (269) | Show / Hide |
Range on Protein: 246-302 Range on HMM: 196-253/269 Sequence Identity: 22% (13 aa) DADEYSFQLK-KKDIIILATDGVTDNIATDDIELFLKDNAARTNDELQLLSQKFVDNV .|| ...|. ..|..|||.||. | . .... ... .|.....|. .....|.. eadvaeveldgsedylilacDGlwDvvneeevvklveefladgaedlsevakllveaa |
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| Phosphatase | PTC7.AA | Subfamily.PPM1G2.PD | 96-198 | 26 | 6.9e-06 | 15.3 | In-house | 37-132 (275) | Show / Hide |
Range on Protein: 96-198 Range on HMM: 37-132/275 Sequence Identity: 26% (27 aa) TSNNVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAayAKIRDekvvKVGGTTAIVAHFpSNGKLEVANLGDSW .|.. . . .| || || . | .. . . . || . . || . . | | .... |..| .. |.||.|. .. || ||| ||| ksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkd--eklkd----esaGstavvvli-keeklyvanaGDsr CGV . . avl |
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