Gene spur_GAK-A
spur_GAK-A
Species: S.purpuratus
Alias: spur_GAK-A
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_GAK-A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | spur_GAK-A.AA | TKL-ciliate1 | 2-138 | 22 | 5.1e-21 | 68.67 | In-house | 66-204 (279) | Show / Hide |
Range on Protein: 2-138 Range on HMM: 66-204/279 Sequence Identity: 22% (32 aa) DTDHGQSEYLLLMELCPGGQLVDAINQRHM---PLSCDDVLQTFYQACRGVQHMHKQTPPVTHRDIKLENFLIGSKKTLKLCDFGSATG---KSYQPDSS .. .. . . ||.|..| ..| | ... . . . .|.|..|. .| |||.| .| | . | |.|.. . . .|. GISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSF WSSLKRSTLEDEFARHTTPMYRPPEILD--LYENFPINHAMDVWS . . | | ||.... ||..| .. | ||| |... QD------MQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYA |
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| Kinase | spur_GAK-A.AA | GAK | 4-137 | 63 | 1.4e-88 | 294.53 | In-house | 74-209 (277) | Show / Hide |
Range on Protein: 4-137 Range on HMM: 74-209/277 Sequence Identity: 63% (86 aa) DHGQSEYLLLMELCPGGQLVDAIN--QRHMPLSCDDVLQTFYQACRGVQHMHKQTPPVTHRDIKLENFLIGSKKTLKLCDFGSATGKSYQPDSSWSSLKR . .| |||||||.| ..|||| |.||| || ||| || ||||| | ||. ||||| ||||||..||.||||||||| ||..||.|||..|| NQSQAEYLLLMEYCKFSQLVDCLKRMECYKPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKR STLEDEFARHTTPMYRPPEILDLYENFPINHAMDVW |..|||..||||||||.||..|||.|.||.|..|.| SMVEDEMFRHTTPMYRSPEMCDLYSNWPIGHKQDIW |
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| Kinase | spur_GAK-A.AA | NAK | 6-138 | 44 | 9.4e-67 | 221.83 | In-house | 85-226 (299) | Show / Hide |
Range on Protein: 6-138 Range on HMM: 85-226/299 Sequence Identity: 44% (63 aa) GQSEYLLLMELCPGGQLVDAINQRHM----PLSCDDVLQTFYQACRGVQHMHKQTP--PVTHRDIKLENFLIGS---KKTLKLCDFGSATGKSYQPDSSW | .|..||||.|..|.|.| .|.| | ....| .|| |.. |.|||.|| . | | .||||| ||.|... ....|||||||.|....||. .| GTWEVFLLMEYCCHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRW SSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWS ....||...|.....||||||.||..||| |.||.. .|.|. EAQYRSMVQDWINKYTTPMYRAPEMCDLYSNCPIDEKVDIWA |
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| Phosphatase | spur_GAK-A.AA | Subfamily.PTEN.PD | 202-368 | 28 | 2.8e-32 | 100.8 | In-house | 1-168 (305) | Show / Hide |
Range on Protein: 202-368 Range on HMM: 1-168/305 Sequence Identity: 28% (49 aa) DISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQ-RTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIH ||||| . .||.|.|.| .| ... ..|. .|.|.. |.... .|. ... ..|..||. .| . ||.| || ...... |.. |.|| ..|| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGP--PGITQ-SQKRYMEYISGMLSptaSIMPHQRV || . ......| . ... | .| ... || |.| ||.||..| | .. | .|. .| CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvk---ssvpyskv |
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| Kinase | spur_GAK-A.AA | NAK-Unclassified | 4-138 | 21 | 5.8e-31 | 105.2 | In-house | 85-329 (405) | Show / Hide |
Range on Protein: 4-138
Range on HMM: 85-329/405
Sequence Identity: 21% (53 aa)
DHGQ--SEYLLLMELCPGGQLVDAIN------QRH---MPLSCDDVLQTFYQACRGVQHMHKQTP-----------------------------------
.|.. |...|||.|..| |.| .| || .. .|| ... |.|.| || . |
NHNNQSYEVFMLMEYCSRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDM
---------PVTHRDIKLENFLIG---------------------------------------------------------SKK-TLKLCDFGSATGKSY
| ||||| || |. . |||||||...
LSSNSAGSIPLIHRDIKIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECII
QPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWS
. . .. |.|. .|||| ||.||..||| . ||. |.|.
TIE---NRQEMQYLQDWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWA
|
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| Phosphatase | spur_GAK-A.AA | PTEN_C2 | 364-502 | 22 | 6.7e-30 | 109.11 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 364-502 Range on HMM: 1-141/141 Sequence Identity: 22% (33 aa) PHQRVLLIKSLRL-TPVPLYNKMRSGC-RPFCEVFHDEERILSTSQEYERMRGF-EVEDASAFIDLNIPVCGDVMVVVYHAR-ST--FGGKVQGKVTGLK |. . | ...... ..| |.. || ||..... .. ...|...|. .. . ... ... ..||.|||.. .|| . |. ... PPPKPLFLHCIIMDHGIPNF-KQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEEC------- MFQFQFNTGFIEPGTKEISFNRYELD-FFEL---DKFAEHFHASLDVVV ||.|.|||.||| ..... |...||| .. ..| . |.. . MFRFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | spur_GAK-A.AA | Subfamily.Tensin.PD | 258-490 | 28 | 1.4e-29 | 91.8 | In-house | 1-225 (237) | Show / Hide |
Range on Protein: 258-490 Range on HMM: 1-225/237 Sequence Identity: 28% (68 aa) FENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKR-----GPPGITQSQKRYMEYI ....| | |.| | | | .|... |.. ||.|| |.|| || . ..|... . .. .. | .| .|..|| . .||.||.||.|| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf SGMLSptASIMPHQRVLLIKSLRLTPVPLYNKmRSGCRPFCEVFHDEeRILSTSQEYErMRGFEVEDASAFIDLNIPVCGDVMVVVYHARSTfggkvqGK .|| .|| .. |... | .| .. ..||||| ... ... || |. . | . | |. . . |||.| || . . | sglls--gsiklnssplflhyvilhgipnfds-kggcrpflkiyqal-qlvytsgvyn-vagedterlcitiepalllkgdvlvkcyhkklr------st vTGLKMFQFQFNTGFIEpgTKEISFNRYELDFFELD-KF .|. || || |. .. |.. .|| | .| -trdvvfrvqfhtgaik--dlklvfekedldealkderf |
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| Kinase | spur_GAK-A.AA | BIKE | 9-137 | 36 | 1.2e-23 | 81.62 | In-house | 75-203 (267) | Show / Hide |
Range on Protein: 9-137 Range on HMM: 75-203/267 Sequence Identity: 36% (49 aa) EYLLLMELCPGGQLVDAINQR-HMP--LSCDDVLQTFYQACRGVQHMHKQTPPVTHRDIKLENFLIGSKK--TLKLCDFGSATGKSYQPDSSWSSLKRST | ..||| | . |.|. .||| . . . ||| | | | .|. |. ||| | || |. ... ||||||||.| .| . . ECMILMEYCRH-QVVNMMNQRLQQGQYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQK--HGVN--Y LEDEFARHTTPMYRPPEILDLYENFPINHAMDVW .|| . || || || ||| .| |.| VKDEIEKYTTMCYRAPEMIDLYSGKEITTKADIW |
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| Kinase | spur_GAK-A.AA | Pkinase | 8-139 | 27 | 8.6e-20 | 71.06 | Pfam | 73-198 (293) | Show / Hide |
Range on Protein: 8-139 Range on HMM: 73-198/293 Sequence Identity: 27% (39 aa) SEYLLLMELCPGG----QLVDAIN-QRHMPL--SCDDVLQTFYQACRGVQHMHKQTPPVTHRDIKLENFLIGSKKTL----KLCDFGSATGKSYQPDSSW ... . ||.|.|| | | | .|| .. | ... .|| .||....|.. . |||.|.||.|| .. .. |.||||.| .. DHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------- SSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWSA . | . . || |..||.. .. .. .. |.||. -Y-NNS-MTTFCG---TPWYMAPEVIR--GGQYYGPKVDMWSC |
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| Phosphatase | spur_GAK-A.AA | CAMK | 2-86 | 20 | 3e-19 | 58.03 | In-house | 120-244 (425) | Show / Hide |
Range on Protein: 2-86
Range on HMM: 120-244/425
Sequence Identity: 20% (26 aa)
DTDHG-----QSEYLLLM---ELCPGG----QLVDAINQR--------------HMPLSCDDVLQTFYQACRGVQHMHKQTPPVTHRDIKLENFLIGSKK
.| .... . | |.|.|| | | | .. . .. ... . | | | .|...|.. . |||.|.|| |. ...
ET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN--IVHRDLKPENILLDDNN
-----------------TLKLCDFGSAT
..|..||| |.
DDSDPVEHDEIFDWNNNNIKIIDFGFAN
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| Kinase | spur_GAK-A.AA | TKL | 5-138 | 19 | 4.7e-19 | 65.26 | In-house | 108-274 (364) | Show / Hide |
Range on Protein: 5-138 Range on HMM: 108-274/364 Sequence Identity: 19% (34 aa) HGQSEYLLLMELCPGGQLVDAINQRHMPLSCDDVLQTFYQACRGVQHMHKQT------PPVTHRDIKLENFLIGSKKT--------------LKLCDFGS ...... . ||.|||| | . .. . .. ....||....| .. ||. |||.| .| |. .. | .|.|||| GPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGL AT-GKSYQPDSSWSS-------LKRSTLEDEFARHTTPMYRPPEILD---LYEN----------FPINHAMDVWS .. . . .. ... .. .. . . || . .||.|. |.. |. . ..||.| SRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS |
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| Phosphatase | spur_GAK-A.AA | Subfamily.TPIP.PD | 258-483 | 25 | 2.2e-18 | 55.3 | In-house | 1-222 (245) | Show / Hide |
Range on Protein: 258-483 Range on HMM: 1-222/245 Sequence Identity: 25% (60 aa) FENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPG-------I-TQSQKRYM |.|||| . |.| | ..... |...|..|| .||| || ||| ..| .|.| . ||. |. .| .| ||.||.. fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv EYISGMLSPTASIMPHQRVLLIKSLRltpvpLYNKMRSGCRPFCEVFHDEERILSTSQEYERMRGFEVEDASAFIDL--NIPVCGDVMVVVYHARstfgg |. . .| .|.|.|| . .|. | .| ... ..|.. . ...| .|.. |.|| | .. . gylaqvkhlynwnlpprrilfikrfi-----iysirgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssn----- kvQGKVTGLKMFQFQFNTGFIEpgTKEISFNRYELD | | | ||| ||. . . . | ||| --lpkyydncpfffwfntsfiq--nnrlclprneld |
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| Kinase | spur_GAK-A.AA | Ciliate-E2 | 12-139 | 17 | 8.1e-18 | 57.72 | In-house | 111-282 (365) | Show / Hide |
Range on Protein: 12-139
Range on HMM: 111-282/365
Sequence Identity: 17% (35 aa)
LLMELCPGGQLVDAINQR-HM---------PLSCDDVLQTFYQACR---------------GVQHMHKQTPPVTHRDIKLENFLIGSKKTLKLCDFGSAT
| ||.| || | | |... . .... ... ..| .. .....|.. . . |||||.|| |. .|..||| ..
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----IKIIDFGLSK
--------------GKSYQPDS----------SWSSLKRSTLEDEFARHT------------TPMYRPPEILDLYE------NFPINHAMDVWSA
| |. . . ||.| .|||| . . ... |.||.
KYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD----------------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL
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| Phosphatase | spur_GAK-A.AA | Family.DSP.PD | 204-470 | 16 | 1.6e-16 | 49.2 | In-house | 95-345 (387) | Show / Hide |
Range on Protein: 204-470 Range on HMM: 95-345/387 Sequence Identity: 16% (45 aa) SYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSqrtYRPAKFEN----RVSDCGFPAKRPPNLVLLyhVCRNMYlWMQR--DPKNVC .| . . | | |.. | . ... .. . .. |. .. ||. . . .|.. .. ..... .|.| .| ... . ... |.|.| tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt---ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvV VIHCMDGKASSATIVSSFLTFCrLFSTVDVSLYMFSVKRgpPGITQSQKRYMEYISGMLSPTasIMPHQRVLLIKSLRLTPVPLYnKMRSGCRPFCEVFH ..||. || |.|... .| .. | . .|.... || ||... ....... . ... . ....|. .. . |. .. .... . lVHCkaGkgRsgtliiaYlmks-egltleealdwvrskR--pgvitpnqgflkqlkdlekek--lkvssevmelrfvissivqnl-gsvevsvsvlkkva DEerilstSQEYERMRGF---EVEDASAFIDLNIPVCGDVMVVVYHarstfggKVQGKVTGLKMFQFQFNTGFIEP | . ..|. | | | .|. ||| | ... | |. .....|.|..|. te------kakldrlkiLvideqekvvitikdglplsgDVkvelfk-------knldkiirdiilntfFvtnyikd |
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| Kinase | spur_GAK-A.AA | CAMKL | 12-86 | 30 | 4e-16 | 47.81 | In-house | 98-177 (297) | Show / Hide |
Range on Protein: 12-86 Range on HMM: 98-177/297 Sequence Identity: 30% (25 aa) LLMELCPGGQ--LVDAINQRH---MPLSCDDVLQTFYQACRGVQHMHKQTPPVTHRDIKLENFLIGSKK--TLKLCDFGSAT | ||.|.|| | | | .. ... .. . | | . .|...|.. . |||||.|| |. ... ..|..||| .. LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSN |
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| Kinase | spur_GAK-A.AA | Ciliate-E2-Unclassified | 14-123 | 21 | 1.7e-15 | 50.24 | In-house | 100-239 (352) | Show / Hide |
Range on Protein: 14-123 Range on HMM: 100-239/352 Sequence Identity: 21% (31 aa) MELCPGGQLVDAINQRHM----------------PLSCDDVL-----QTFYQACRGVQHMHKQTPPVTHRDIKLENFLIGSKK---TLKLCDFGSATGKS ||.|.|| | . |..|. ... .. . |.| . | ...|.. . |||||.|| |. ... .|..|||.. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ YQPDSSWSSL--KRSTLEDEFARHT--TPMYR----PPEILD ..... . |.. . .. . .. ||.| .||.|. QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| Kinase | spur_GAK-A.AA | S_TKc | 3-225 | 15 | 1.1e-08 | -49.35 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 3-225 Range on HMM: 19-231/231 Sequence Identity: 15% (44 aa) TDHG-----------------------------------Q-SEYLLLMELCPG--GQLVDAINQRHMP-----LSCDDVLQTFYQACRGVQHMHKQTPPV .... | ... . ||.|.| | | | | .| . .. .. .|| |......|.. . RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GI THRDIKLENFLIGSKKTLKLCDFGSATGKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINH-AMDVWSAVHSKLDVFVFMSFL-HPAV |||.| || |. . ..|.||||.|. || |..||.| . .. . |.|| . . .. . | IHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL------GYGKCKCDWWS-----CGCILYEMLCGYPPF PDSVDSAGNFLGMMKGAGGNLLRNLKDTSSRVAQTVASYTKSELDISYITSRIIVMS-----FPAEGLE-------STYK | . |.| | |. .. . ... .. | |. . P-------QMQMMFKKIG-----------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| spur_GAK-A.AA | Protein | None | 1205 | None | Fasta, JSON |
| spur_GAK-A.NA | RNA | None | 3615 | None | Fasta, JSON |