Gene spur_GAK-B
spur_GAK-B
Species: S.purpuratus
Alias: spur_GAK-B
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_GAK-B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | spur_GAK-B.AA | GAK | 34-62 | 70 | 9.5e-13 | 38.61 | In-house | 1-30 (277) | Show / Hide |
Range on Protein: 34-62 Range on HMM: 1-30/277 Sequence Identity: 70% (21 aa) LKVRRVIAE-GFAFVYVAQENSTGKEFALK . ||.|||| |||||||||. ||.|.||| YRVRCVIAEGGFAFVYVAQDVQTGREYALK |
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| Kinase | spur_GAK-B.AA | GAK | 64-200 | 65 | 2.6e-110 | 367.8 | In-house | 139-277 (277) | Show / Hide |
Range on Protein: 64-200 Range on HMM: 139-277/277 Sequence Identity: 65% (91 aa) ENFLIGSKKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINANY ||||||..||.|||||||||.||..||.|||..|||..|||..||||||||.||..|||.|.||.|..|.||.|||||.||||||||||.|||||||.|| ENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNY T--IPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL . ||..|..||..||||||.|||.|..|. .| .. MKPIPPQDNQYMCFHDLIRACLQVNPDERLDIAMVVEYM |
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| Kinase | spur_GAK-B.AA | NAK | 64-200 | 46 | 2.6e-81 | 271.15 | In-house | 152-299 (299) | Show / Hide |
Range on Protein: 64-200 Range on HMM: 152-299/299 Sequence Identity: 46% (69 aa) ENFLIGS---KKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFED------SA ||.|... ....|||||||.| ...||. .|....||...|.....||||||.||..||| |.||.. .|.||||||||.||...||||| |. ENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYTTPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSS KLRIINANYT--IPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL ||.|.|.||. ||... .. .|||||.||..||..|| . .. || KLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| Kinase | spur_GAK-B.AA | NAK-Unclassified | 75-202 | 35 | 4.9e-36 | 123.19 | In-house | 272-405 (405) | Show / Hide |
Range on Protein: 75-202 Range on HMM: 272-405/405 Sequence Identity: 35% (49 aa) KLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLR-------IIN--ANYTI |||||||.. . . .. |.|. .|||| ||.||..||| . ||. |.||||| ||.||. |||.. | |.. ..|.. KLCDFGSCCECIITIE---NRQEMQYLQDWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEF PEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQLQE | || ||. ||..||..|| . . .. . PSNHNYSNQLHNLIKIMLNEDPIQRPNIYQVLNHICQ |
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| Phosphatase | spur_GAK-B.AA | Subfamily.PTEN.PD | 284-440 | 29 | 5.5e-32 | 99.9 | In-house | 1-161 (305) | Show / Hide |
Range on Protein: 284-440 Range on HMM: 1-161/305 Sequence Identity: 29% (46 aa) DISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQ-RTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIH ||||| . .||.|.|.| .| ... ..|. .|.|.. |.... .|. ... ..|..||. .| . ||.| || ...... |.. |.|| ..|| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGP--PGITQ-SQKRYMEYISGMLSP || . ......| . ... | .| ... || |.| ||.||..| | .. CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvks |
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| Kinase | spur_GAK-B.AA | BIKE | 61-191 | 41 | 6.1e-31 | 108.08 | In-house | 132-259 (267) | Show / Hide |
Range on Protein: 61-191 Range on HMM: 132-259/267 Sequence Identity: 41% (55 aa) LKLENFLIGSKK--TLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRI || || |. ... |||||||| | .| . . .|| . || || || ||| .| |.|||||||| .|. ||. | .| | LKVENILLHDHGPPHYVLCDFGSATNKFLNPQK--HGVN--YVKDEIEKYTTMCYRAPEMIDLYSGKEITTKADIWALGCMLYKLCFFCLPFGES-QLAI INANYTIPEDDEEYMILHDLIRAMLQVDPRNRP . |.|||. .| ||| || .|. || CDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRP |
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| Kinase | spur_GAK-B.AA | Ciliate-E2 | 61-191 | 19 | 1.1e-20 | 67.73 | In-house | 187-353 (365) | Show / Hide |
Range on Protein: 61-191
Range on HMM: 187-353/365
Sequence Identity: 19% (37 aa)
LKLENFLIGSKKTLKLCDFGSAT--------------SKSYQPDS----------SWSSLKRSTLEDEFARHT------------TPMYRPPEILDLYE-
.|.|| |. .|..||| .. .| |. . . ||.| .|||| .
IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD----------------QIIQQNMFNTICGTPGYMAPEILNGKKY
-----NFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINA-NYTIP----------------EDDEEYMILHDLIRA----MLQVDPRNRP
. ... |.|.||..|| |.. ..|| ...| .. .| . .. |||. |||.|| .|.
DNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI
|
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| Phosphatase | spur_GAK-B.AA | CAMK | 61-194 | 19 | 2.4e-18 | 55.08 | In-house | 205-417 (425) | Show / Hide |
Range on Protein: 61-194 Range on HMM: 205-417/425 Sequence Identity: 19% (42 aa) LKLENFLIGSKK-----------------TLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFA-------------RHTTPMYRP-PEILD--------- ||.|| |. ... ..|..||| |. . .. | . . . || | . ||.| LKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN --LYENFPINHAMDVWALGCMLYTMCYRQHPFEDS-----------------AKLRIINANYT-IPED--------DEEYMI-------------LHDLI . |. ... . |.|..|..||.| ||... . .|....|. .|. ..|. ||| ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLI RAMLQVDPRNRPPLE | |||||| .|. .| RKMLQVDPEKRMTIE |
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| Kinase | spur_GAK-B.AA | Pkinase | 61-200 | 21 | 5.1e-17 | 61.25 | Pfam | 134-293 (293) | Show / Hide |
Range on Protein: 61-200
Range on HMM: 134-293/293
Sequence Identity: 21% (38 aa)
LKLENFLIGSKKTL----KLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINHAMDVWALGCMLYTMCYRQHPFEDS---
||.||.|| .. .. |.||||.| .. . | . . || |..||.. .. .. .. |.|..||.|| |. .. || ..
LKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCG---TPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWH
---AKLRIINANYT------IPEDDEEY-----------------MILHDLIRAMLQVDPRNRPPLEVIVAQ--L
.. .|. . .|...... . |.|. .|..|| || | |. .
DNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | spur_GAK-B.AA | Ciliate-E2-Unclassified | 61-191 | 18 | 1.8e-16 | 53.66 | In-house | 170-341 (352) | Show / Hide |
Range on Protein: 61-191 Range on HMM: 170-341/352 Sequence Identity: 18% (33 aa) LKLENFLIGSKK---TLKLCDFGSATSKSYQPDSSWSSL--KRSTLEDEFARHT--TPMYR----PPEIL--DLYE--NFPINHAMDVWALGCMLYTMCY .|.|| |. ... .|..|||.. ..... . |.. . .. . .. ||.| .||.| |. . .. |.|.||. || |.. IKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEMLF RQHPFE--DSAK----------------LRIINANYTIPEDDEEY----MILH--------DLIRAMLQVDPRNRP ..||. .. . |. . . | . .. .... ||.. ||...| .|. GYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI |
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| Kinase | spur_GAK-B.AA | TKL | 61-200 | 17 | 1.9e-16 | 55.76 | In-house | 166-364 (364) | Show / Hide |
Range on Protein: 61-200 Range on HMM: 166-364/364 Sequence Identity: 17% (35 aa) LKLENFLIGSKKT--------------LKLCDFGSATSKSYQPDSSWSS--------LKRSTLEDEFARHTTPMYRPPEILD---LYEN----------F || .| |. .. | .|.|||| ....| ... .. .. .. . . || . .||.|. |.. | LKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGF PINHAMDVWALGCMLYTMCYRQHPFEDSAKLRII---------NANY------TIPE--------DDEEYM--ILHDLIRAMLQVDPRNRPPLEVIVAQL . . ..||.. | .|. .. |..|..| .| .. .||. ..... . .|. . ||..|| . |. .| EYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | spur_GAK-B.AA | TKL-ciliate1 | 61-200 | 24 | 6.9e-16 | 50.85 | In-house | 131-279 (279) | Show / Hide |
Range on Protein: 61-200 Range on HMM: 131-279/279 Sequence Identity: 24% (38 aa) LKLENFLIGSKKTLKLCDFGSATS---KSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILD--LYENFPINHAMDVWALGCMLYTMCYRQHPFEDSAK || .| | . | |.|.. . . .|. . . | | ||.... ||..| .. | ||| |..|.| .| .| | ||. | LKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQD------MQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPFQQ--K LRIINANYTIPEDD------------EEYMILHDLIRAMLQVDPRNRPPLEVIVAQL . || ..| .|.|. .. .| || . | | MSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL |
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| Kinase | spur_GAK-B.AA | MPSK | 132-200 | 38 | 7e-16 | 53.56 | In-house | 207-281 (281) | Show / Hide |
Range on Protein: 132-200 Range on HMM: 207-281/281 Sequence Identity: 38% (29 aa) DVWALGCMLYTMCYRQHPFE------DSAKLRIINANYTIPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL |.| ||| || ||| |.. || | . | | |||. .|.|| |. ||| || .. |. DIWSLGCVLYAMCYFHSPYDMIYQRGDSVHLAVQNRNFNIPENSRYSQDMHQLISYMMRVDPMERPHIFWVLNQT |
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| Kinase | spur_GAK-B.AA | S_TKc | 34-204 | 16 | 3e-10 | -26.57 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 34-204
Range on HMM: 1-231/231
Sequence Identity: 16% (44 aa)
LKVRRVIAEG-FAFVYVAQENSTGKEFA------------------------------------------------------------------------
.. |.| .| |. || .....||...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM
-------------------LKLENFLIGSKKTLKLCDFGSATSKSYQPDSSWSSLKRSTLEDEFARHTTPMYRPPEILDLYENFPINH-AMDVWALGCML
|| || |. . ..|.||||.|. || |..||.| . .. . |.|..||.|
YQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCIL
YTMCYRQHPFEDSAKLRIINANYTIPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVA-----QLQEIA
| |.... ||. .... . |.|| .||.||..|| . . . .
YEMLCGYPPFP--QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | spur_GAK-B.AA | NAK | 34-62 | 35 | 2e-09 | 27.55 | In-house | 1-39 (299) | Show / Hide |
Range on Protein: 34-62 Range on HMM: 1-39/299 Sequence Identity: 35% (14 aa) LKVRRVIAE-GFAFVYVAQ---------ENSTGKEFALK ..|....|| ||..||..| ||.|...||| YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALK |
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| Phosphatase | spur_GAK-B.AA | Subfamily.Tensin.PD | 340-575 | 27 | 2e-25 | 78.2 | In-house | 1-225 (237) | Show / Hide |
Range on Protein: 340-575 Range on HMM: 1-225/237 Sequence Identity: 27% (67 aa) FENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKR-----GPPGITQSQKRYMEYI ....| | |.| | | | .|... |.. ||.|| |.|| || . ..|... . .. .. | .| .|..|| . .||.||.||.|| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyf SGMLSptASIMPHQRVLLIKSLRLTPVPLYNKMrSGCpsvRPYVRTSVPDELIRF-GGHEVKGQrgfEVEDASAFIDLNIPVCGDVMVVVYHARSTfggk .|| .|| .. |... | .| .. .|| ||... .|. | ..| |. . | |. .. |||.| || . . sglls--gsiklnssplflhyvilhgipnfdsk-ggc---rpflkiyqalqlvytsgvynvage---dterlcitiepalllkgdvlvkcyhkklr---- vqGKvTGLKMFQFQFNTGFIEpgTKEISFNRYELDFFELD-KF | .|. || || |. .. |.. .|| | .| --st-trdvvfrvqfhtgaik--dlklvfekedldealkderf |
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| Phosphatase | spur_GAK-B.AA | PTEN_C2 | 446-587 | 21 | 7.1e-25 | 91.16 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 446-587 Range on HMM: 1-141/141 Sequence Identity: 21% (33 aa) PHQRVLLIKSLRL-TPVPLYNKMRSGCPSVRPYVRTSVPDELI-RFGGHEVKGQRGFEVEDASAFIDLNIPVCGDVMVVVYHAR-ST--FGGKVQGKVTG |. . | ...... ..| |.. || .|||.. |. . . . .... . ... ... ..||.|||.. .|| . |. ... PPPKPLFLHCIIMDHGIPNF-KQGGGC--WRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEEC----- LKMFQFQFNTGFIEPGTKEISFNRYELD-FFEL---DKFAEHFHASLDVVV ||.|.|||.||| ..... |...||| .. ..| . |.. . --MFRFWFNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | spur_GAK-B.AA | Subfamily.TPIP.PD | 340-456 | 30 | 1.1e-17 | 53.0 | In-house | 1-125 (245) | Show / Hide |
Range on Protein: 340-456 Range on HMM: 1-125/245 Sequence Identity: 30% (38 aa) FENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPG-------I-TQSQKRYM |.|||| . |.| | ..... |...|..|| .||| || ||| ..| .|.| . ||. |. .| .| ||.||.. fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv EYISGMLSPTASIMPHQRVLLIKSL |. . .| .|.|.|| . gylaqvkhlynwnlpprrilfikrf |
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| Phosphatase | spur_GAK-B.AA | Family.DSP.PD | 286-554 | 16 | 5.7e-15 | 44.1 | In-house | 95-344 (387) | Show / Hide |
Range on Protein: 286-554 Range on HMM: 95-344/387 Sequence Identity: 16% (45 aa) SYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSqrtYRPAKFEN----RVSDCGFPAKRPPNLVLLyhVCRNMYlWMQR--DPKNVC .| . . | | |.. | . ... .. . .. |. .. ||. . . .|.. .. ..... .|.| .| ... . ... |.|.| tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt---ddkpqftkelgikylripidDhnapplenl--fekaid-fieegndskgvV VIHCMDGKASSATIVSSFLTFCrLFSTVDVSLYMFSVKRgpPGITQSQKRYMEYISGMLSPTASimPHQRVLLIKSLRLTPVPLYNKMRSGCPSVRPYVR ..||. || |.|... .| .. | . .|.... || ||... ....... . ... . ....|. .. . |. ... . .. .. lVHCkaGkgRsgtliiaYlmks-egltleealdwvrskR--pgvitpnqgflkqlkdlekeklk--vssevmelrfvissivqnlgsvevsvsvlkkvat TSV-PDELIRFgGHEvkgqrgfEVEDASAFIDLNIPVCGDVMVVVYHarstfggKVQGKVTGLKMFQFQFNTGFIE .|.| . | | | .|. ||| | ... | |. .....|.|..|. ekakldrlkiL-vid-------eqekvvitikdglplsgDVkvelfk-------knldkiirdiilntfFvtnyik |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| spur_GAK-B.AA | Protein | None | 1289 | None | Fasta, JSON |
| spur_GAK-B.NA | RNA | None | 3870 | None | Fasta, JSON |