Gene spur_DUSP12
spur_DUSP12
Species: S.purpuratus
Alias: spur_DUSP12
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_DUSP12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | spur_DUSP12.AA | DSPc | 4-145 | 23 | 4e-26 | 94.04 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 4-145 Range on HMM: 1-172/172 Sequence Identity: 23% (41 aa) YADEILPRLWLGDLQAAE--SERFLNDRKISHVLSLI-NMPI---------------TVPSEVAVNHKQII-IRD-------QPGEDLLTHLEDILAFME ||.|.|.|| .. . .|| .| ||.... . |. .. ....| | | ...... ... .|.. GPSEITPHLYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFIH DGLDPAKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKV-----VDKH-SQTCPNTGFMEQLKLFEAM | .| | |||||..|.||| . .|||.|....... |. | .. .. ||| .|. ||...| . DC--RQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP12.PD | 6-147 | 51 | 9.9e-53 | 168.5 | In-house | 3-143 (143) | Show / Hide |
Range on Protein: 6-147 Range on HMM: 3-143/143 Sequence Identity: 51% (73 aa) DEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPI-TVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVI .||||.|.||.|.|..... |.. ||.||||.|.... . | |..|.| | |.| ||||.||.....|.|.|| .|||.|||||..|||||...|| seilpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieegl--ekegavlvHClagvSRSvtivi AYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAMGC ||.|.|||..| .|||.| .|.....||.||.|||||||.|.. AYlmkkeklslekAlklvkekkkeiepNegFleQLklfekmkk |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP19.PD | 7-144 | 41 | 4.8e-34 | 107.6 | In-house | 4-138 (139) | Show / Hide |
Range on Protein: 7-144 Range on HMM: 4-138/139 Sequence Identity: 41% (58 aa) EILPRLWLGDLQAAESERFLNDRKISHVLSLI-NMPITVPSEVavNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVIA |. |||.|| ..|.... |. .|| |.|.. ..| . |... . |.| | |.| ..||..|...| |.|.... |.| ||||| |||||.| ||| evkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdf--tyksieilDlpetkllsylkealdFieears--kdgrvlvHCnAGvSRsasvvia YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA |.| .|. | .||.|| ... .||.||..||| .|| ylmkdeelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | spur_DUSP12.AA | Family.DSP.PD | 5-167 | 31 | 1.9e-30 | 96.8 | In-house | 107-267 (387) | Show / Hide |
Range on Protein: 5-167 Range on HMM: 107-267/387 Sequence Identity: 31% (50 aa) ADEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVI ||||.|.|| |.||... |.. .......| . .| ... .| | | . ..| ..| .. |.|.| | ..| ||||| .|..||. .|||. pseilphlylgsllaaknlewlkelgvtkivnltddkpqftkelgikylripidDhnapplenlfekaidfieegnd--skgvVlVHCkaGkgRsgtlii AYIMYKEKCPLVTALKKVVDKHS-QTCPNTGFMEQLKLFEAMGCQCDTTNsQFKQHRLSHLAEE |..|.. | ||. | .|.. .. || ||..||| .| . .. .. .... |. .. aYlmksegltleealdwvrskRpgvitpnqgflkqlkdlekeklkvssev-melrfvissivqn |
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| Phosphatase | spur_DUSP12.AA | Subfamily.LRR-DSP.PD | 6-144 | 35 | 4.7e-30 | 94.7 | In-house | 3-136 (137) | Show / Hide |
Range on Protein: 6-144 Range on HMM: 3-136/137 Sequence Identity: 35% (48 aa) DEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEvaVNHKQIIIRDQPGEDLLTHLEDILAFMEDGldpAKEGSVLVHCAMGVSRSSSAVIA |.|...|.|| ...| . .|.| ...|.|.. .. | . | |.| . |. |.... ||...| ..| ||.|||||||...||||. dliidklylgcresamnksilkdnnvthilavadfkplypdl--fkyliidiedvdeadiyqhfkemnafideg---rekggvlihcragvsrsatlvia YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA | |.. . || |..| .. ||.||..||| ||. ylmkknslkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP1.PD | 6-143 | 33 | 7.5e-29 | 91.0 | In-house | 3-137 (139) | Show / Hide |
Range on Protein: 6-143 Range on HMM: 3-137/139 Sequence Identity: 33% (46 aa) DEILPRLWLGDLQAAESERFLNDRKISHVLSLINMpITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVIA |||. |.|| . | . ..|.. ||...| . .. . | ..|.| . |.. .|.....|... |... .|.| |||||..|.|||.. |.|| veildfLyLGsaehasnlqlLkelkitallnvsae-lpnvfeelfkyksipvednkkadisslfeeaidfidsvk--kkgGrvlvhCqaGisrsativla YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE .| ..|. | | . | .. | || ||..|| || yLmkekkvrleeafefvkqrrsiisPnfgfvgqLlefe |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP6.PD | 7-144 | 36 | 4.7e-28 | 88.1 | In-house | 4-140 (141) | Show / Hide |
Range on Protein: 7-144 Range on HMM: 4-140/141 Sequence Identity: 36% (50 aa) EILPRLWLGDLQAAESERFLNDRKISHVLSLI-NMPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVIA ||||.|.|| ..|. |.. ||..|| . |.| . .. ...||| |.|. ..| ... . ..|.... |. .||||| ||||| . ..| eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidears--kkskvlvhclaGvsrsvtvtla YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA |.| |... | | . | .|.|. .|| ||.||. || ylmkklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP14.PD | 7-143 | 33 | 3.8e-27 | 85.5 | In-house | 4-136 (138) | Show / Hide |
Range on Protein: 7-143 Range on HMM: 4-136/138 Sequence Identity: 33% (47 aa) EILPRLWLGdLQAAESERFLNDRKISHVlslINMPITVPSEV--AVNHKQIIIRDQPGEDLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVI || . |.|. .||.... |. .||... .|. . .|. |.. .| ..|.| ..| .|.. . . .|. .|.| .||||..||||| | |. eitesLyls-gaaalkkeklkkkkitli---vnvttelpetkledvktvkikveDkpeaklaehfdevadkieev--kkkgGktlvhCvaGvsRsAslvl AYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE ||.| || | | | | .. .. .||.|| .|| .| aylmkyeklsLreayklvksaRpiirPnvGFwkqlidyE |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP10.PD | 7-143 | 34 | 8.5e-27 | 84.2 | In-house | 4-139 (141) | Show / Hide |
Range on Protein: 7-143 Range on HMM: 4-139/141 Sequence Identity: 34% (48 aa) EILPRLWLGDLQAAESERFLNDRKISHVLSLIN-MPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVIA .||| |.||. . |... |. |..|| . . .| . . .|..|.| ..|.. ..| ...|. |.|.|. ....||||| |.|||. ||| silpflllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieear--krgsrvlvhchaGisrsatvvia YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE |.| . | | | | .| .|| .|| || || yvmkhlslslseaykfvkekrPiisPnlnfmGqllefe |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP15.PD | 6-143 | 32 | 2.5e-25 | 79.5 | In-house | 3-136 (138) | Show / Hide |
Range on Protein: 6-143 Range on HMM: 3-136/138 Sequence Identity: 32% (45 aa) DEILPRLWLGDLQAAESERFLNDRKISHVLSLINMPITVPSEvaVNHKQIIIRDQPGEDLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVIA ...|| |..|... |. . |.. ||.|.||. . . . . .... | . | | || ..... |. ..|.|||||. |.||| . |.| nkvlpGlyvGnfrdakdkeqleenkithilsihdsakplled--ikylcikaadsPdqdlskffkesidfihkc--rleggnvlvhclaGisrsvtlvva YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE ||| . ||| |. | . ||.|| .||. || yimtvtelswedalkavkaarsvanPnvGfrrqlqefe |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP3.PD | 5-141 | 31 | 8.1e-25 | 77.9 | In-house | 2-144 (148) | Show / Hide |
Range on Protein: 5-141 Range on HMM: 2-144/148 Sequence Identity: 31% (45 aa) ADEILPRLWLGDLQAAESERFLNDRKISHVLSLINM--------PITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDPaKEGSVLVHCAMGV .||. |....|| ..|. .. |. | ||| . . ... ... . ..| | || .. | |... |. |.| |||||..|. vdevypkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsq-kngkvlvhcvvGi SRSSSAVIAYIMYKEKCPLVTALKKVvDKHSQTCPNTGFMEQLKL |||. |.||.| ..| |. |.|.| |. . ||.||..|| sRsatlvlayLmirrkltlkeaiktv-rkkreilPneGflkqLle |
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| Phosphatase | spur_DUSP12.AA | Subfamily.Slingshot.PD | 7-145 | 34 | 4.3e-24 | 75.4 | In-house | 4-139 (139) | Show / Hide |
Range on Protein: 7-145 Range on HMM: 4-139/139 Sequence Identity: 34% (47 aa) EILPRLWLGDLQAAESERFLNDRKISHVLSLINmPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVIAY .| |.|| | |........| . . | . .....| . |.. .|||.| .. |.| .|. .|||||||||||.|.|||| kifdhlylGsewnasnleelkengveyilnvtk-eidnffpekfkylnirvydeeetdllkhwnetykfiekak--ekgskvlvhckmGvsrsastviay IMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEAM | . .. | .||. | .. | . ||.||..||| .| . amkeyelsleealeyvkerrsiikpnkgflkqlkvyegi |
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| Phosphatase | spur_DUSP12.AA | Subfamily.STYXL1.PD | 4-144 | 29 | 1.8e-22 | 70.5 | In-house | 1-142 (143) | Show / Hide |
Range on Protein: 4-144 Range on HMM: 1-142/143 Sequence Identity: 29% (41 aa) YADEILP-RLWLGDLQAAESERFLNDRKISHVLSLINM--PITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSS | |.|| .|.||. . | ... .| |. .. . . .. . ... .| ..|.. |||..|... |.|. .. ||||.||| ...| yPvevlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkk--egevvlvfsnkGisrsa SAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA ||.||..| | .|.|.. . .. .|| .|.|||. .| aviiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | spur_DUSP12.AA | DSPc | 12-145 | 23 | 2.3e-22 | 79.7 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 12-145 Range on HMM: 1-151/151 Sequence Identity: 23% (36 aa) LWLGDLQAAE-SERFLNDRKISHVLSLI-----NMPITVPSEVAVNHKQII-IRD---------QPGEDLLTHLEDILAFMEDGLDPAKEGSVLVHCAMG |.|| ... ...|| .|.||.... | .. ....| . | ..... ... . .|..| .| | |||||..| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNN---WFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDC--RQKGGKVLVHCQAG VSRSSSAVIAYIMYKEKCPLVTALKKV-----VDKH-SQTCPNTGFMEQLKLFEAM .||| . .|||.|.. .... |. | .. .. .||..|. || .| . ISRSACLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP8.PD | 7-143 | 33 | 8.1e-22 | 68.2 | In-house | 4-139 (143) | Show / Hide |
Range on Protein: 7-143 Range on HMM: 4-139/143 Sequence Identity: 33% (46 aa) EILPRLWLGDLQAAESERFLNDRKISHVLSL-INMPITVPSEVAVNHKQIIIRDQPGEDLLTHLEDILAFMEDGLdpAKEGSVLVHCAMGVSRSSSAVIA .||| |.|| . . .| .|.. ||.|| . . |..| . .. .| ..|. |.|| ... | |.. ...|.||||| | |||.. .|| rilpnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkar--sangkvlvhclaGisrsatvaia YIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE ||| . . | | . | .| . || |..|| .| yimktlemsldeayrfvkekrptispnlnflgqLleye |
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| Phosphatase | spur_DUSP12.AA | Subfamily.STYX.PD | 6-144 | 31 | 1.4e-16 | 51.1 | In-house | 3-145 (146) | Show / Hide |
Range on Protein: 6-144 Range on HMM: 3-145/146 Sequence Identity: 31% (46 aa) DEILPRLWLGDLQAAESER--FLNDRKISHVLSLINMP---ITVPSeVAVNH--KQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSR .|||| |.|| || . |... |.|.. . . . . | . . . |.. |... .| . .|..| |. | | |||| |.|| qeilpglflgpysaamksklevlkehgithivcirqnieanlikpn-fpdrfrylvldvadntveniirylptvkefiddslq--kggkvlvhgnagisr SSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFEA |.. |||||| .| . | .. || ||..||| .|| saalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea |
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| Phosphatase | spur_DUSP12.AA | Subfamily.PTPMT1.PD | 50-143 | 29 | 7.5e-10 | 29.3 | In-house | 53-144 (146) | Show / Hide |
Range on Protein: 50-143 Range on HMM: 53-144/146 Sequence Identity: 29% (28 aa) VNHKQIIIRDQPGEDLLTHLEDILAFMEDGLDpaKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE |.. |. . | . | .||. . |.|. . |. || ||| | .||.. |..|.|.|.|. | | . .| .| .. .. |. |. veqlqlatvDfteapslekleegvefiekvas--kgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqefk |
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| Phosphatase | spur_DUSP12.AA | Subfamily.DSP23.PD | 21-119 | 23 | 7.9e-08 | 22.9 | In-house | 4-100 (128) | Show / Hide |
Range on Protein: 21-119 Range on HMM: 4-100/128 Sequence Identity: 23% (23 aa) ESERFLNDRKISHVLSLINMPIT-VPSEVAVNHKQIIIRDQPGEdLLTHLEDILAFMEDGldPAKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTAL . .|| |. | ...|| . . . . . .. ..| | | | .. .. .|. .||..| ||||.|. |. . . |.. .|. |. davqfladqGirvlvslttegapyseaapsltlrridipdfcPP-aleqvarlvriveea--ekkeeavgvhcalGlGrtGtllacylvkeeglaaddai |
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| Phosphatase | spur_DUSP12.AA | Subfamily.PTPDC1.PD | 84-143 | 25 | 3e-07 | 20.6 | In-house | 165-224 (229) | Show / Hide |
Range on Protein: 84-143 Range on HMM: 165-224/229 Sequence Identity: 25% (15 aa) KEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLVTALKKVVDKHSQTCPNTGFMEQLKLFE .|| . ||| | | . . .|..|... |.|.| .| ... . .| .. |. eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelveeFa |
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| Phosphatase | spur_DUSP12.AA | Subfamily.PTEN.PD | 69-116 | 28 | 3.9e-06 | 16.8 | In-house | 78-125 (305) | Show / Hide |
Range on Protein: 69-116 Range on HMM: 78-125/305 Sequence Identity: 28% (13 aa) LEDILAFMEDGLDPAKEGSVLVHCAMGVSRSSSAVIAYIMYKEKCPLV ||.| .. |. |. | ||| .| |. . ||.... ... leeivedvdkwLkedksnVvavHCkaGkGRtGvmicayLlksgikksa |
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| Phosphatase | spur_DUSP12.AA | Subfamily.R_Nematode_3.PD | 86-110 | 39 | 5.8e-06 | 16.3 | In-house | 199-223 (267) | Show / Hide |
Range on Protein: 86-110 Range on HMM: 199-223/267 Sequence Identity: 39% (9 aa) GSVLVHCAMGVSRSSSAVIAYIMYK .|.||| |.||| . . . . | tpvvVHCsdGisRsatlaaielgyq |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| spur_DUSP12.AA | Protein | None | 264 | None | Fasta, JSON |
| spur_DUSP12.NA | RNA | None | 792 | None | Fasta, JSON |
| spur_DUSP12.AA.PD_4-145 | Protein Phosphatase Domain | None | 142 | None | Fasta, JSON |