Gene spur_MKP
spur_MKP
Species: S.purpuratus
Alias: spur_MKP
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_MKP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Rhodanese | spur_MKP.AA | Rhodanese | 157-244 | 22 | 5.9e-09 | 30.05 | Pfam | 14-102 (102) | Show / Hide |
Range on Protein: 157-244 Range on HMM: 14-102/102 Sequence Identity: 22% (21 aa) MLILDVRDRADYNASHVTTA-RHSTAVDTEHD--CLVSQGKLDKFTMV-VVYDQGSTSQTVDPTLSSFVQRLKDANV--DVLILSGGYDTFHKT ..|.|||....|...|. | .. | . . |||| . . |||. . . . . || . . .| .|.||.. ... YVIIDVRPPEEYEKGHIPGAHVNIPW--LEEEHDLEELGIKLDKDKPIIVVYC--HGNRSG-AWACLVWWMLKAMGYPPNVYVLDGGWEAWKAE |
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| Phosphatase | spur_MKP.AA | Family.DSP.PD | 252-405 | 31 | 7.3e-36 | 115.0 | In-house | 91-245 (387) | Show / Hide |
Range on Protein: 252-405 Range on HMM: 91-245/387 Sequence Identity: 31% (50 aa) LTIRSEQDRMLHFKSYPSVVLEdTLYQGNVKHSKNETVLKNLKITHILNVSTECANaFPK--SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRV .. . .. . ...|| .|. || |. .. ||.. ||.|..|.|.|..... . | | ...||.. ..| ... . ..|.| .|. .. .|.|.| fdldtydhfervengkpseilp-hlylgsllaaknlewlkelgvtkivnltddkpq-ftkelgikylripidDhnapplenlfekaidfieegndskgvV FVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRS-IAAPNRGFLIQLSKFEQ .||| .||.|| | .||.||...|.||..| ......|. .. || ||| ||...|. lVHCkaGkgRsgtliiaYlmksegltleealdwvrskRpgvitpnqgflkqlkdlek |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP1.PD | 268-405 | 44 | 9.9e-46 | 146.0 | In-house | 2-138 (139) | Show / Hide |
Range on Protein: 268-405 Range on HMM: 2-138/139 Sequence Identity: 44% (62 aa) PSVVLeDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAF |. .| | || | .|. | .||.||||..||||.|. |.|...|.| ...|||.... | ..| |..|. |. ..||||.||| .| |||.| .|. pveil-dfLyLGsaehasnlqlLkelkitallnvsaelpnvfeelfkyksipvednkkadisslfeeaidfidsvkkkgGrvlvhCqaGisrsativlay LMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ ||. . ..|..|.|..|.|||| .|| ||. || .||. LmkekkvrleeafefvkqrrsiisPnfgfvgqLlefek |
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| Phosphatase | spur_MKP.AA | DSPc | 276-406 | 29 | 3.4e-44 | 155.6 | Pfam | 1-151 (151) | Show / Hide |
Range on Protein: 276-406 Range on HMM: 1-151/151 Sequence Identity: 29% (45 aa) LYQGNVKHSK-NETVLKNLKITHILNVSTECAN---AFPKSFEYLQVK-VED---------ESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSS ||.|. .|.. .. |....|||..|...|| | ...|.|.... |.| . .. | .....| .|.......||.| ||| | ||| LYLGSYPHHMADPAFLQKHGITHVINCTMECPNNWFYHNSHFHYMWIPHVHDHIHYYHIHWNHCTNISQYFPMATDFIDDCRQKGGKVLVHCQAGISRSA TCTIAFLMSYRGWTLKDAHEYL-----KDRR-SIAAPNRGFLIQLSKFEQL . .||.||.||......| ... |.|| .. || .|. || .|. CLCIAYLMKYRNMSYNEAYDFVYIYHMKQRRCPMISPNMNFWRQLCEYERQ |
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| Phosphatase | spur_MKP.AA | DSPc | 267-406 | 28 | 2.7e-43 | 151.09 | SMART | 1-172 (172) | Show / Hide |
Range on Protein: 267-406 Range on HMM: 1-172/172 Sequence Identity: 28% (49 aa) YPSVVLEDTLYQGNVKHSK--NETVLKNLKITHILNVSTECAN-----------------AFPKSFEYLQVK-VED-------ESTEHIGPHLERAAKFV || ... ||.|. .|. | ||...|||..||. || . ....|.|... ..| . ...| ........|. GPSEITPH-LYLGSYPHHMEPNPCFLKKHNITHVINVTMECPWNFHHCQKNDMHYTNEWIYHNSHFQYMHIPMIDDIYYHIRWNHCTNISQYFPEVYDFI ASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYL-----KDRR-SIAAPNRGFLIQLSKFEQL .....||.|.||| | ||| | .||.||.|..... || ... |.|| .| || .|. || .|. HDCRQKGGKVLVHCQAGISRSATLCIAYLMKYMNMSYNDAYHFVYIYHIKQRRCPIICPNFNFWHQLCEWERK |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP19.PD | 271-405 | 37 | 8.8e-39 | 123.3 | In-house | 4-138 (139) | Show / Hide |
Range on Protein: 271-405 Range on HMM: 4-138/139 Sequence Identity: 37% (50 aa) VLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMS .....|| | . .....||.|||||||||... |.||| |.|..... |.. ... .|..| .|. .| ...|||.||| | |||.. ||.||. evkprlylgsqdvaadkeilkklkitHilnvavgvpnvfpkdftyksieilDlpetkllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmk YRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ . .|..| |.... | . || ||. || ..|. deelslekalekvrearpcikPneGFikqLkeyea |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP14.PD | 273-405 | 33 | 2.4e-37 | 118.8 | In-house | 6-137 (138) | Show / Hide |
Range on Protein: 273-405 Range on HMM: 6-137/138 Sequence Identity: 33% (44 aa) EDTLYQGnVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR ...|| . . .....||. |||.|.||.|| .. ........||||...... .|....|. . .. ..||...||||.| ||| ...|.|| |. tesLyls-gaaalkkeklkkkkitlivnvttelpetkledvktvkikveDkpeaklaehfdevadkieevkkkgGktlvhCvaGvsRsAslvlaylmkye GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ .|..|....|..|.| || || || ..|. klsLreayklvksaRpiirPnvGFwkqlidyEk |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP6.PD | 272-405 | 35 | 3.1e-34 | 108.4 | In-house | 5-140 (141) | Show / Hide |
Range on Protein: 272-405 Range on HMM: 5-140/141 Sequence Identity: 35% (48 aa) LEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK--SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLM . ..|| |. |...| |||.||| ..|||... |.| . ...|.|. .||. .. . .. | .|. | .. |.||| | |||| |.|.||. ilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkykqipiedhlsqnlakffPeaiefidearskkskvlvhclaGvsrsvtvtlaylm SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ .. .|.||....|...| .|| |. || .||. kklalslndaydlvkkkksnisPnfnfmgqlldfer |
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| Phosphatase | spur_MKP.AA | Subfamily.Slingshot.PD | 273-404 | 41 | 1.1e-33 | 106.8 | In-house | 6-137 (139) | Show / Hide |
Range on Protein: 273-404 Range on HMM: 6-137/139 Sequence Identity: 41% (54 aa) EDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR | || | . | ||. ....||||..|. | ||..|.||...| ||..... .| ... ||. | ..| .|.||| | |||.. ||. | . fdhlylGsewnasnleelkengveyilnvtkeidnffpekfkylnirvydeeetdllkhwnetykfiekakekgskvlvhckmGvsrsastviayamkey GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFE ..|..|.||.|.||||. ||.||| ||...| elsleealeyvkerrsiikpnkgflkqlkvye |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP10.PD | 275-405 | 35 | 6.4e-33 | 104.4 | In-house | 8-140 (141) | Show / Hide |
Range on Protein: 275-405 Range on HMM: 8-140/141 Sequence Identity: 35% (46 aa) TLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK--SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR |. || | .... .|. | |...||| |.. | | . ..| ...|.|...... ..| | .|. | . |.||.||| | |||.|.||..| . . flllGnekdaadkdaldrlgikyvlnvttsvPnffeekglvrykripvsdsgkqnlkqkfeealefieearkrgsrvlvhchaGisrsatvviayvmkhl GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ .|..|....|..| | .|| .|. || .||. slslseaykfvkekrPiisPnlnfmGqllefek |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP12.PD | 273-406 | 34 | 1.5e-32 | 103.4 | In-house | 6-141 (143) | Show / Hide |
Range on Protein: 273-406 Range on HMM: 6-141/143 Sequence Identity: 34% (47 aa) EDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK--SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMS .. || |.... .... ||.|||||.| | .| . . | . ....... || .| . ||..| .|. .... .| |.||| | |||.| ||.|| lpglylggleavqerellkelkithvlsvikeelpelqkekgvkskliqilDepeedlLshldeavrFieeglekegavlvHClagvSRSvtiviAYlmk YRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL .... |..|.. .|. .. . || ||| || ||.. keklslekAlklvkekkkeiepNegFleQLklfekm |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP3.PD | 274-404 | 34 | 1.9e-31 | 99.7 | In-house | 7-146 (148) | Show / Hide |
Range on Protein: 274-404 Range on HMM: 7-146/148 Sequence Identity: 34% (49 aa) DTLYQGNVKHSKNETVLKNLKITHILNVSTECA--------NAFPK-SFEYLQVKVEDESTEHIGPHLERAAKFVASAINS-GGRVFVHCVQGKSRSSTC . .| |. . .|... ||.| |||.|| . .. ... . . .|| |.|.| . .. . |.||.|...|... .|.|.||||.| |||.|. pkvyvgdeavakdkekLkklGithvLnaaegkrllkvdtdaefYkdleikylGvevsDvpefdlskyfeeaadfidealsqkngkvlvhcvvGisRsatl TIAFLMSYRGWTLKDAHEYLKDRRSIaAPNRGFLIQLSKFE .|.|| .| |||.| . ...|.| ||.||| || ... vlayLmirrkltlkeaiktvrkkrei-lPneGflkqLleld |
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| Phosphatase | spur_MKP.AA | Subfamily.LRR-DSP.PD | 273-405 | 37 | 3.2e-31 | 98.7 | In-house | 6-136 (137) | Show / Hide |
Range on Protein: 273-405 Range on HMM: 6-136/137 Sequence Identity: 37% (49 aa) EDTLYQGNVKHSKNETVLKNLKITHILNVStECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGrVFVHCVQGKSRSSTCTIAFLMSYR | || | . ..|...||....|||| |. .. .|. | || ...|| .| |... |. . ..|| |..|| | |||.| .||.|| .. idklylgcresamnksilkdnnvthilava-dfkplypdlfkyliidiedvdeadiyqhfkemnafidegrekgg-vlihcragvsrsatlviaylmkkn GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ ..|.| . ...|. |||||| || |||. slkfkealdlvikkrpriypnrgfldqlkkfek |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP8.PD | 274-405 | 35 | 8e-31 | 97.7 | In-house | 7-140 (143) | Show / Hide |
Range on Protein: 274-405 Range on HMM: 7-140/143 Sequence Identity: 35% (47 aa) DTLYQGNVKHSKNETVLKNLKITHILNVSTECAN--AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSY . || | |.| .|..||.| |...||.|..| . | ..|.. |.|. .|.. |....| .|. | .. |.|.||| |.|||.|||..| . pnlylGsqkdsldeellkklgisyvlnisescpkdvellkesrflriPvkDkyeekllpwfdkalefidkarsangkvlvhclaGisrsatvaiayimkt RGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ .| .|....|..|. || || || ..|. lemsldeayrfvkekrptispnlnflgqLleyek |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP15.PD | 275-405 | 33 | 2.1e-30 | 96.2 | In-house | 8-137 (138) | Show / Hide |
Range on Protein: 275-405 Range on HMM: 8-137/138 Sequence Identity: 33% (44 aa) TLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKsFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGW || ||.. .|... |.. |||||| . . ... ..|| .|..| .. ... . .|. .. || |.|||. | ||| | ..|..|. .. GlyvGnfrdakdkeqleenkithilsihdsakplled-ikylcikaadsPdqdlskffkesidfihkcrleggnvlvhclaGisrsvtlvvayimtvtel TLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ .|| . .| ||.| || || || .||. swedalkavkaarsvanPnvGfrrqlqefek |
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| Phosphatase | spur_MKP.AA | Subfamily.STYXL1.PD | 267-405 | 35 | 2.6e-28 | 89.7 | In-house | 1-142 (143) | Show / Hide |
Range on Protein: 267-405 Range on HMM: 1-142/143 Sequence Identity: 35% (49 aa) YPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTE---CANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTC ||. || . || || |...|... |.||. .|||.. .. .. . |...||||. .. ..|... .|. . ..| |.|.| ||| . || yPvevlPgklylGnykqaqnpaikkdlkvkahvnvssdaekliagladvakllhiavedeneadllerlkevvqfiekhkkegevvlvfsnkGisrsaav TIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ .|| .. .|||.|..|||. .. |||.|. |||..|. iiaylmyskkitlkkaykylkkckenvkPnrafveqlseWek |
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| Phosphatase | spur_MKP.AA | Subfamily.STYX.PD | 283-405 | 36 | 3.4e-23 | 72.9 | In-house | 19-145 (146) | Show / Hide |
Range on Protein: 283-405 Range on HMM: 19-145/146 Sequence Identity: 36% (45 aa) HSKNEtVLKNLKITHILNVSTEC-----ANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLK .|| | |||. ||||. . . ||..| || . | |...| | .| .. .|. .....||.|.|| | |||.. ||..|| ..|. kskle-vlkehgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyr DAHEYLKDRRSIAAPNRGFLIQLSKFEQ |...|| .|| || || ..| eafayvqerrfcinpnegfvsqlkeyea |
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| Phosphatase | spur_MKP.AA | Subfamily.PTPMT1.PD | 312-403 | 26 | 2.8e-16 | 50.4 | In-house | 52-143 (146) | Show / Hide |
Range on Protein: 312-403 Range on HMM: 52-143/146 Sequence Identity: 26% (24 aa) SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKF |.||. . | .||.. .|. . .. | .|.||| |..||.| ...|| . .. ..|...||..|.. . . |..| GveqlqlatvDfteapslekleegvefiekvaskgssvYvHCkAGrtRsatlvacylmkkkklspeeavkflkkkRpqirlkskqwralqef |
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| Phosphatase | spur_MKP.AA | Subfamily.Laforin.PD | 313-390 | 29 | 5.2e-10 | 30.0 | In-house | 71-148 (165) | Show / Hide |
Range on Protein: 313-390 Range on HMM: 71-148/165 Sequence Identity: 29% (23 aa) FEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIA . |. . .|| ||| | .| .. . .. | .|.||| | ||.. ||. ||.|. .| .| .. layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv |
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| Phosphatase | spur_MKP.AA | Subfamily.DSP23.PD | 290-387 | 24 | 1.2e-07 | 22.6 | In-house | 9-107 (128) | Show / Hide |
Range on Protein: 290-387 Range on HMM: 9-107/128 Sequence Identity: 24% (25 aa) LKNLKITHILNVSTECANAfPKSFEYLQVKVEdESTEHIGPHLERAAKF---VASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDR | . | ......||.|. .. . | .. . .. | ||. |.. | | .... | |||..| |. | .|. .| . .|| .. | ladqGirvlvslttegapy-seaapsltlrri-dipdfcPPaleqvarlvriveeaekkeeavgvhcalGlGrtGtllacylvkeeglaaddaiaevrkr R | r |
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| Phosphatase | spur_MKP.AA | Subfamily.PTPDC1.PD | 336-406 | 21 | 2.9e-06 | 17.6 | In-house | 157-226 (229) | Show / Hide |
Range on Protein: 336-406 Range on HMM: 157-226/229 Sequence Identity: 21% (15 aa) AKFVASAInSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL | |..|. . |.. ||| |. | ..|. . | ..| . ....|. . |. . ...|... vkvvdfal-eegkiavHCHAGlGRtGvliacylvyakrltaeeaiklvrskrpksiqtreqvelveeFalf |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| spur_MKP.AA | Protein | None | 420 | None | Fasta, JSON |
| spur_MKP.NA | RNA | None | 1260 | None | Fasta, JSON |
| spur_MKP.AA.PD2_267-406 | Protein Phosphatase Domain | None | 140 | None | Fasta, JSON |