Gene spur_PTEN-B
spur_PTEN-B
Species: S.purpuratus
Alias: spur_PTEN-B
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_PTEN-B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | spur_PTEN-B.AA | Family.DSP.PD | 8-277 | 25 | 5.8e-38 | 122.4 | In-house | 84-348 (387) | Show / Hide |
Range on Protein: 8-277 Range on HMM: 84-348/387 Sequence Identity: 25% (70 aa) RFIDKGFDLDLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCsernYDTTKFYN----RVAHYPFDDHNPPRLELIkpFCEDLDn .||| . .| . .. | | | |...| .|. . .. . |. |. ||. .| ..|.. .. ..|.||||.| ||.. |....| gfidvhtfdldtydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid- WLGA--DGQNVAAIHCKAGKGRTGVMICAYMLHRrLYQTASEALDFYASKRtknrKGVTIPSQRrYVEYYGNLIVRELEYKPTTLLLTRIDLETVPMFNG .. | ..|...||||||||.|..|.||.... |..||||...||| .||..|.|. ..... | . |. . ... | ... |. . fieegndskgvVlVHCkaGkgRsgtliiaYlmks-egltleealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgs GSCAPAFVI-YQQKVKIFSSQPYEVAKKERSVRCEFPLPVPICGDIKIEFFNK-PNKLKKDRMFHFWFNTFFVANSNL . . .. . . . | .. .| .|. ||.|.|.|.| ..| .| .. ..|.| .. . | vevsvsvlkkvatekakldrlkiLvideqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdesl |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.PTEN.PD | 17-280 | 38 | 9.2e-81 | 262.7 | In-house | 1-265 (305) | Show / Hide |
Range on Protein: 17-280
Range on HMM: 1-265/305
Sequence Identity: 38% (103 aa)
DLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIH
|.|||..|.|....|.|..|...... . ...... .. ...|...|..........| .|||.|||||||||.|||.....||.|.|| .|.||.|.||
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH
CKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNRKGVTIPSQRRYVEYYGNLIVRELEYKPTTLLLTRIDletvpmFNGGSCAPAFVIYQQKVK
||||||||||||||.|.. ...|.|||..|..||||..||||||||||||.|. .|. . | .| .. | |.|| . . . . ..
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceir------fsesscvqnlgmvecsis
IFSSQPYEVAKKERS------VRCEF----PLPVPICGDIKIEFFNKPNklkKDRMFHFWFNTFFVANSNLLNS
| || .| .. | .|..||.|.|. .| . |||.||||| | . .|
vlhdsatenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkksp---dkiichfwlntffvrnyspces
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| Phosphatase | spur_PTEN-B.AA | Subfamily.TPIP.PD | 74-282 | 31 | 1.1e-38 | 124.5 | In-house | 1-219 (245) | Show / Hide |
Range on Protein: 74-282 Range on HMM: 1-219/245 Sequence Identity: 31% (70 aa) FYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNR-----KGVTIPSQRRYV | ||| . |||| |.|| . |......|| .| .|| ||||| |||||| ..||.... ...|| |.||.....||.. .|||||.|||.| fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv EYYGNLIV-RELEYKPTTLLLtrIDLETVPMFNGGSCAPAFVIYQQKVKIFSSQPYEVAKKERSVRCE-----FPLPVPICGDIKIEFFNKP-NKLKKDR . ... . . | .|. | . | | . .| .||| . . . .. |. |.|..||. | . | gylaqvkhlynwnlpprrilf--ikrfiiysirgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyydnc MFHFWFNTFFVANSNLLNSSS ||||| |. |. | . pfffwfntsfiqnnrlclprn |
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| Phosphatase | spur_PTEN-B.AA | PTEN_C2 | 181-344 | 26 | 2.6e-38 | 138.41 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 181-344 Range on HMM: 1-141/141 Sequence Identity: 26% (47 aa) YKPTTLLLTRIDL-ETVPMF-NGGSC-APAFVIYQQKVKI-FSSQPYEVAK---KERSVRCEFPLPVPICGDIKIEFFNK--PN--KLKKDRMFHFWFNT ..| .| |..| . ...|.| ||.| | . |||...|. ... |. .| ..... .|| |.|..||.||....| .. ..... ||.||||| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT FFVANSNLLNSSSQQDLANNGSSDNSSHCSEDNMEALDADCTVLRLQKDQLDRANKDKTNKWYSPNFKVICYFKR .|. . . ..|...|..||.|.|||..| ..|.|||. .|.. CFIEH----------------------------------NNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.Tensin.PD | 76-287 | 33 | 7.1e-37 | 118.3 | In-house | 3-219 (237) | Show / Hide |
Range on Protein: 76-287 Range on HMM: 3-219/237 Sequence Identity: 33% (72 aa) NRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTK--NRKGVTIPSQRRYVEYYGN ..| . . |. | || . |. |. || || ||| ..||| ||||.||.|.||| . .. ..|..||| .| || .||| |||||||||. . ekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsg LIVRELEYKPTTLLLTRIDLETVPMFN-GGSCAPAFVIYQQKVKIFSSQPYEVAKKER-SVRCEFPLPVPICGDIKIEFFNKPNK-LKKDRMFHFWFNTF |. ... . |.| . |...| |. .|.| | . ||| ...| |.|| ... .. . . ||. .. .| . ..| .| | | llsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvqfhtg FVANSNLLNSSSQQDLA . . .| . .. | | aikdlklvfekedldea |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.CDC14.PD | 35-168 | 28 | 4.4e-13 | 40.7 | In-house | 127-251 (258) | Show / Hide |
Range on Protein: 35-168 Range on HMM: 127-251/258 Sequence Identity: 28% (39 aa) LE-GVYRNKLEVVVKFFNEKHGEryKVYNLCsERNYDTTKFYNR-VAHY--PFDDHNPPRLELIKPFCEDLDNWLGAdgqnvAAIHCKAGKGRTGVMICA .| | .. | ....|... . .. | .. || .|| . .||. | | | ...| | | ... || .|.|||||||||..| .| vedGytllaPeklleyfrknnvt--tivrLn-kklYdakkftdaGfahlDlffiDGtvPsdailkkfleitekaeGa-----iavhCkaGLGrtgtligc YMLHRRLYqTASEALDFYASkrtkNRKGVTIPSQRRYV .... . ||.|.. . | | | |. |. ylikhyrf-taaetiawlri----arPGsvigpqqtyl |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.PTPDC1.PD | 112-154 | 48 | 5.2e-12 | 36.9 | In-house | 168-209 (229) | Show / Hide |
Range on Protein: 112-154 Range on HMM: 168-209/229 Sequence Identity: 48% (20 aa) VAAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRTK |.|| ||.|||||.|..|... . . ||.||... |||.| kiavHCHAGlGRtGvliacylvyakrl-taeeaiklvrskrpk |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.PRL.PD | 48-154 | 27 | 3.2e-11 | 34.4 | In-house | 16-123 (140) | Show / Hide |
Range on Protein: 48-154 Range on HMM: 16-123/140 Sequence Identity: 27% (29 aa) KFFNEKHGERYKVYNLCSERNYDTTKFYN---RVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLyqTASEA || .| . |. | . | .||..|. . .| ..||| ..| |... . | | . . ... |.|| || ||. |... .. .. .|.. kfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--kyeda LDFYASKRTK | .|| vefirekrrg |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.DSP11.PD | 66-152 | 25 | 6.2e-11 | 33.5 | In-house | 32-122 (141) | Show / Hide |
Range on Protein: 66-152 Range on HMM: 32-122/141 Sequence Identity: 25% (23 aa) ERNYDTTKFYNR-VAHYP--FDDHNPPRLELIKPFCEDLDNWLG--ADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQtASEALDFYASKR .| |..... .. | .. |. | | .| |.| ....| .| ... ..|| | ||| .|| |.... |. ...|.. . .| dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegys-pedaieafeear |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.DSP23.PD | 82-154 | 23 | 1.1e-09 | 29.6 | In-house | 40-106 (128) | Show / Hide |
Range on Protein: 82-154 Range on HMM: 40-106/128 Sequence Identity: 23% (17 aa) PFDDHNPPRLELIKPFCEDLDNwlGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYqTASEALdfyASKRTK .|. || || .. . . ... . .. ..|| | |||| .. |... . . .|..|. | | . dipdfcPPaleqvarlvrivee--aekkeeavgvhcalGlGrtGtllacylvkeegl-aaddai---aevrkr |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.RNGTT.PD | 87-154 | 26 | 3.1e-09 | 27.9 | In-house | 56-122 (140) | Show / Hide |
Range on Protein: 87-154 Range on HMM: 56-122/140 Sequence Identity: 26% (18 aa) NPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQtASEALDFYASKRTK . | | .| | . ...| ..| ..|| | ||| .|.||.... .. ..|.. .|. | . eaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedws-veaavalfakarpp |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.PTPMT1.PD | 89-156 | 27 | 7.1e-09 | 26.9 | In-house | 67-131 (146) | Show / Hide |
Range on Protein: 89-156 Range on HMM: 67-131/146 Sequence Identity: 27% (19 aa) PRLELIKPFCEDLDNWLgADGQNVaAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRTKNR | || .. | ... .|..| .|||||..| . .. .|..... . .. || .| ..|| . | pslekleegvefiekva-skgssv-YvHCkAGrtRsatlvacylmkkkkl-speeavkflkkkRpqir |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.N5_RR.PD | 30-141 | 21 | 9.2e-08 | 23.0 | In-house | 114-228 (265) | Show / Hide |
Range on Protein: 30-141 Range on HMM: 114-228/265 Sequence Identity: 21% (24 aa) FPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFynrVAHYPF----DDHNPPRLELIKPFCEDLDNWLGADGQNVA--AIHCKAGKGR || . . . .| .|. . .. . |.| .| . . .. | || . | . | . . . .... .. .. ...|.|| || ||||. fPdaedyeiserygdveikveeiverndysvrklvlkylervers---vkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGr TGVMICAYMLHRRLYQTA .|.. . |.| .. tGcfiaisiavrqlreei |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.R_Sponge_2.PD | 45-153 | 18 | 3.2e-07 | 21.3 | In-house | 126-235 (262) | Show / Hide |
Range on Protein: 45-153 Range on HMM: 126-235/262 Sequence Identity: 18% (21 aa) VVVKFFNEKHGERYKVYNLCSERNYDtTKFYNRVAHYPF----DDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLyqT ..|.. .|.. . |.. .| .. .. . |... | .. | . . ... . .|... ..|..| |||||. ... .|| | fkvtlkeeekladyiirklklskeks-segeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfialdsvlerl--k ASEALDFYASKRT | .| . .| aeeeidvfevlkt |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.R_Anemone_2.PD | 85-164 | 22 | 1.3e-06 | 19.4 | In-house | 168-247 (262) | Show / Hide |
Range on Protein: 85-164 Range on HMM: 168-247/262 Sequence Identity: 22% (19 aa) DHNPPR--LELIKpFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTAseALDFYAS-KRTKNRKGVTIPSQ |.. | .|.. . . ... |... ..|| || ||||| | .| .|. . | .| . |. .... . . . degvpesgaslld-lvrqvekaqqesgagpivvhcsaGvGrtGvfiavdillerikaea--lvdvfqtvkqlreqrnlmvqtk |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.RB.PD | 44-147 | 18 | 1.7e-06 | 18.8 | In-house | 126-228 (261) | Show / Hide |
Range on Protein: 44-147 Range on HMM: 126-228/261 Sequence Identity: 18% (19 aa) EVVVKFFNEKHGERYKVYNLCSERNYDtTKFYNRVAHYPFDDHNPPR-LELIKPFCEDLDNWLGAD-GQNVAAIHCKAGKGRTGVMICAYMLHRRLYQta .. |. .||. . . . .. |.. . .. ... . . ||. |. . . |.. ..... .. .. .|| || ||||. | .| ... . dikvtllaekeldewvirefkiekgke-krkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqaiee-- SEALDF .. .| ndyvdv |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.N12.PD | 57-148 | 22 | 1.9e-06 | 18.4 | In-house | 147-238 (270) | Show / Hide |
Range on Protein: 57-148 Range on HMM: 147-238/270 Sequence Identity: 22% (21 aa) RYKVYNLCSERNYDTTKFYNrVAHYPFDDHN-PPRLELIKPFCEDLDNWLGaDGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTAS-EALDFY . . | |.. .. |.| . . ||. | . . . . |.. . . . .. ..|| || ||||..| . .. | . | ||. dflirtLkveaqkesrkvyq-fhytaWPDhgvPssaksllelielvrelqe-sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvf |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.N6.PD | 45-152 | 23 | 4e-06 | 17.5 | In-house | 155-267 (295) | Show / Hide |
Range on Protein: 45-152 Range on HMM: 155-267/295 Sequence Identity: 23% (25 aa) VVVKFFNEKHGERYKVYNLCSERNyDTTKFYNRVAHYPF---DDHNPP-RLELIKPFCEDLDNWLG-ADGQNVAAIHCKAGKGRTGVMICAYMLH-RRLY . |. .||. ..|.. .. ... |. | .. .| | ||. | . . | ||... . .|| || |||| .| ... . itvtsisEkstadYtlRefsvshk-dkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkkqeelekagpivvhcsaGiGrtGtfividivlkiieq QTASEALDFYASKR .|.. | . sgldvdidisksik |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.DSP19.PD | 110-146 | 24 | 5.3e-06 | 17.6 | In-house | 79-114 (139) | Show / Hide |
Range on Protein: 110-146 Range on HMM: 79-114/139 Sequence Identity: 24% (9 aa) QNVAAIHCKAGKGRTGVMICAYMLHRRLYQtASEALD ... .||.|| |. .. ||..... . ..||. dgrvlvHCnAGvSRsasvviaylmkdeels-lekale |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.RK.PD | 59-167 | 15 | 6.1e-06 | 16.8 | In-house | 145-255 (267) | Show / Hide |
Range on Protein: 59-167 Range on HMM: 145-255/267 Sequence Identity: 15% (17 aa) KVYNLCS-ERNYDTTKFYNRVAHYPFDDH--NPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLyQtASEALDFY-ASKRTK ...... |... .. ... . . .. | . . . .... ... .|| || ||.|. | .. . . . .| .| | .| rifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidivlemi-e-regvvdvfnavktlr NRKGVTIPSQRRY || . . .| nrkvnmveteeqy |
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| Phosphatase | spur_PTEN-B.AA | Subfamily.R_Ecdysozoa.PD | 109-171 | 25 | 9.7e-06 | 16.1 | In-house | 200-261 (269) | Show / Hide |
Range on Protein: 109-171 Range on HMM: 200-261/269 Sequence Identity: 25% (16 aa) GQNVAAIHCKAGKGRTGVMICAYMLHRRLYqtASEALDFYAS-KRTKNRKGVTIPSQRRYVEYY . .||.|| ||.|.... .| .| | . .| .. | .... . . | ..|| | srsPivvhCsaGvgrsgifvaldlllqqlk--aedkvdifetvkkLrsqrnllvqsleqyvfly |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| spur_PTEN-B.AA | Protein | None | 393 | None | Fasta, JSON |
| spur_PTEN-B.NA | RNA | None | 1179 | None | Fasta, JSON |
| spur_PTEN-B.AA.PD_74-176 | Protein Phosphatase Domain | None | 103 | None | Fasta, JSON |