spur_PTEN-B
Species: S.purpuratus
Alias: spur_PTEN-B
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: DSP
Subfamily: PTEN
Protein domain

Protein domains of spur_PTEN-B.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Phosphatase spur_PTEN-B.AA Family.DSP.PD 8-277 25 5.8e-38 122.4 In-house 84-348 (387) Show / Hide
Range on Protein: 8-277
Range on HMM: 84-348/387
Sequence Identity: 25% (70 aa)

RFIDKGFDLDLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCsernYDTTKFYN----RVAHYPFDDHNPPRLELIkpFCEDLDn
.||| .     .|   . .. | | | |...|  .|. . .. . |.    |. ||.    .| ..|..    .. ..|.||||.| ||..  |....| 
gfidvhtfdldtydhfervengkpseilphlylgsllaaknlewlkelgvtkivnlt----ddkpqftkelgikylripidDhnapplenl--fekaid-

WLGA--DGQNVAAIHCKAGKGRTGVMICAYMLHRrLYQTASEALDFYASKRtknrKGVTIPSQRrYVEYYGNLIVRELEYKPTTLLLTRIDLETVPMFNG
..    | ..|...||||||||.|..|.||....    |..||||...|||    .||..|.|. .....  |  . |. . ... | ... |. .    
fieegndskgvVlVHCkaGkgRsgtliiaYlmks-egltleealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgs

GSCAPAFVI-YQQKVKIFSSQPYEVAKKERSVRCEFPLPVPICGDIKIEFFNK-PNKLKKDRMFHFWFNTFFVANSNL
.   .   .. .   . .    | ..  .|       .|. ||.|.|.|.| ..|  .| .. ..|.| .. .  |  
vevsvsvlkkvatekakldrlkiLvideqekvvitikdglplsgDVkvelfkknldkiirdiilntfFvtnyikdesl

Phosphatase spur_PTEN-B.AA Subfamily.PTEN.PD 17-280 38 9.2e-81 262.7 In-house 1-265 (305) Show / Hide
Range on Protein: 17-280
Range on HMM: 1-265/305
Sequence Identity: 38% (103 aa)

DLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIH
|.|||..|.|....|.|..|...... . ...... .. ...|...|..........| .|||.|||||||||.|||.....||.|.|| .|.||.|.||
disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH

CKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNRKGVTIPSQRRYVEYYGNLIVRELEYKPTTLLLTRIDletvpmFNGGSCAPAFVIYQQKVK
||||||||||||||.|..  ...|.|||..|..||||..||||||||||||.|. .|.   . |   .| .. |       |.||   . . .  . .. 
CkaGkGRtGvmicayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceir------fsesscvqnlgmvecsis

IFSSQPYEVAKKERS------VRCEF----PLPVPICGDIKIEFFNKPNklkKDRMFHFWFNTFFVANSNLLNS
    | || .|       ..  |       .|..||.|.|. .|        . |||.||||| | .  .|   
vlhdsatenakpdrlktlpidfqksfvltikpsipvsgdvkfeltkksp---dkiichfwlntffvrnyspces

Phosphatase spur_PTEN-B.AA Subfamily.TPIP.PD 74-282 31 1.1e-38 124.5 In-house 1-219 (245) Show / Hide
Range on Protein: 74-282
Range on HMM: 1-219/245
Sequence Identity: 31% (70 aa)

FYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNR-----KGVTIPSQRRYV
| ||| .   |||| |.|| .  |......|| .| .|| ||||| |||||| ..||....  ...|| |.||.....||..      .|||||.|||.|
fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv

EYYGNLIV-RELEYKPTTLLLtrIDLETVPMFNGGSCAPAFVIYQQKVKIFSSQPYEVAKKERSVRCE-----FPLPVPICGDIKIEFFNKP-NKLKKDR
. ...   . .  |  .|.  |    .    |  |     .  .|  .|||     .   . . ..          |.  |.|..||.    |   .  |
gylaqvkhlynwnlpprrilf--ikrfiiysirgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqffssnlpkyydnc

MFHFWFNTFFVANSNLLNSSS
 ||||| |. |. |    .  
pfffwfntsfiqnnrlclprn

Phosphatase spur_PTEN-B.AA PTEN_C2 181-344 26 2.6e-38 138.41 Pfam 1-141 (141) Show / Hide
Range on Protein: 181-344
Range on HMM: 1-141/141
Sequence Identity: 26% (47 aa)

YKPTTLLLTRIDL-ETVPMF-NGGSC-APAFVIYQQKVKI-FSSQPYEVAK---KERSVRCEFPLPVPICGDIKIEFFNK--PN--KLKKDRMFHFWFNT
..| .| |..| . ...|.|  ||.|  | . |||...|.  ... |. .|   .....  .|| |.|..||.||....|  ..  ..... ||.|||||
PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT

FFVANSNLLNSSSQQDLANNGSSDNSSHCSEDNMEALDADCTVLRLQKDQLDRANKDKTNKWYSPNFKVICYFKR
.|. .                                  . ..|...|..||.|.|||..| ..|.|||. .|..
CFIEH----------------------------------NNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE

Phosphatase spur_PTEN-B.AA Subfamily.Tensin.PD 76-287 33 7.1e-37 118.3 In-house 3-219 (237) Show / Hide
Range on Protein: 76-287
Range on HMM: 3-219/237
Sequence Identity: 33% (72 aa)

NRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTK--NRKGVTIPSQRRYVEYYGN
..|  . . |.  | || .   |. |. || || ||| ..||| ||||.||.|.||| . .. ..|..||| .| ||      .||| |||||||||. .
ekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfsg

LIVRELEYKPTTLLLTRIDLETVPMFN-GGSCAPAFVIYQQKVKIFSSQPYEVAKKER-SVRCEFPLPVPICGDIKIEFFNKPNK-LKKDRMFHFWFNTF
|.  ... .   |.|  . |...| |. .|.| | . |||    ...|  |.|| ... ..       . . ||. .. .|  .  ..| .|   | |  
llsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkklrsttrdvvfrvqfhtg

FVANSNLLNSSSQQDLA
. . .|  . .. | | 
aikdlklvfekedldea

Phosphatase spur_PTEN-B.AA Subfamily.CDC14.PD 35-168 28 4.4e-13 40.7 In-house 127-251 (258) Show / Hide
Range on Protein: 35-168
Range on HMM: 127-251/258
Sequence Identity: 28% (39 aa)

LE-GVYRNKLEVVVKFFNEKHGEryKVYNLCsERNYDTTKFYNR-VAHY--PFDDHNPPRLELIKPFCEDLDNWLGAdgqnvAAIHCKAGKGRTGVMICA
.| |   .. | ....|...  .  ..  |  .. || .|| .  .||.   | |   |  ...| | | ...  ||     .|.|||||||||..| .|
vedGytllaPeklleyfrknnvt--tivrLn-kklYdakkftdaGfahlDlffiDGtvPsdailkkfleitekaeGa-----iavhCkaGLGrtgtligc

YMLHRRLYqTASEALDFYASkrtkNRKGVTIPSQRRYV
....  . ||.|.. .        | |  |  |. |. 
ylikhyrf-taaetiawlri----arPGsvigpqqtyl

Phosphatase spur_PTEN-B.AA Subfamily.PTPDC1.PD 112-154 48 5.2e-12 36.9 In-house 168-209 (229) Show / Hide
Range on Protein: 112-154
Range on HMM: 168-209/229
Sequence Identity: 48% (20 aa)

VAAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRTK
|.|| ||.|||||.|..|... . . ||.||...  |||.|  
kiavHCHAGlGRtGvliacylvyakrl-taeeaiklvrskrpk

Phosphatase spur_PTEN-B.AA Subfamily.PRL.PD 48-154 27 3.2e-11 34.4 In-house 16-123 (140) Show / Hide
Range on Protein: 48-154
Range on HMM: 16-123/140
Sequence Identity: 27% (29 aa)

KFFNEKHGERYKVYNLCSERNYDTTKFYN---RVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLyqTASEA
|| .| . |. |    . | .||..|. .   .|  ..||| ..|  |... . | | .    . ... |.|| || ||. |...  ..   ..  .|..
kfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--kyeda

LDFYASKRTK
|  .||    
vefirekrrg

Phosphatase spur_PTEN-B.AA Subfamily.DSP11.PD 66-152 25 6.2e-11 33.5 In-house 32-122 (141) Show / Hide
Range on Protein: 66-152
Range on HMM: 32-122/141
Sequence Identity: 25% (23 aa)

ERNYDTTKFYNR-VAHYP--FDDHNPPRLELIKPFCEDLDNWLG--ADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQtASEALDFYASKR
.| |..... .. | ..      |. |  | .| |.| ....|   .| ... ..||  |  ||| .|| |....  |. ...|.. . .| 
dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegys-pedaieafeear

Phosphatase spur_PTEN-B.AA Subfamily.DSP23.PD 82-154 23 1.1e-09 29.6 In-house 40-106 (128) Show / Hide
Range on Protein: 82-154
Range on HMM: 40-106/128
Sequence Identity: 23% (17 aa)

PFDDHNPPRLELIKPFCEDLDNwlGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYqTASEALdfyASKRTK
.|. || || .. . . ...    . ..  ..||  | |||| ..  |... . . .|..|.   |  | .  
dipdfcPPaleqvarlvrivee--aekkeeavgvhcalGlGrtGtllacylvkeegl-aaddai---aevrkr

Phosphatase spur_PTEN-B.AA Subfamily.RNGTT.PD 87-154 26 3.1e-09 27.9 In-house 56-122 (140) Show / Hide
Range on Protein: 87-154
Range on HMM: 56-122/140
Sequence Identity: 26% (18 aa)

NPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQtASEALDFYASKRTK
. |  | .| | .  ...|    ..| ..||  |  ||| .|.||....  ..  ..|.. .|. | .
eaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedws-veaavalfakarpp

Phosphatase spur_PTEN-B.AA Subfamily.PTPMT1.PD 89-156 27 7.1e-09 26.9 In-house 67-131 (146) Show / Hide
Range on Protein: 89-156
Range on HMM: 67-131/146
Sequence Identity: 27% (19 aa)

PRLELIKPFCEDLDNWLgADGQNVaAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRTKNR
| || ..   | ...    .|..|  .|||||..| . .. .|..... . .. || .| ..|| . |
pslekleegvefiekva-skgssv-YvHCkAGrtRsatlvacylmkkkkl-speeavkflkkkRpqir

Phosphatase spur_PTEN-B.AA Subfamily.N5_RR.PD 30-141 21 9.2e-08 23.0 In-house 114-228 (265) Show / Hide
Range on Protein: 30-141
Range on HMM: 114-228/265
Sequence Identity: 21% (24 aa)

FPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFynrVAHYPF----DDHNPPRLELIKPFCEDLDNWLGADGQNVA--AIHCKAGKGR
|| .    .  .  .| .|. . .. . |.| .|  .   . ..    | || .    | . | . . .  .... ..   .. ...|.|| || ||||.
fPdaedyeiserygdveikveeiverndysvrklvlkylervers---vkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGr

TGVMICAYMLHRRLYQTA
.|.. .  |.| ..    
tGcfiaisiavrqlreei

Phosphatase spur_PTEN-B.AA Subfamily.R_Sponge_2.PD 45-153 18 3.2e-07 21.3 In-house 126-235 (262) Show / Hide
Range on Protein: 45-153
Range on HMM: 126-235/262
Sequence Identity: 18% (21 aa)

VVVKFFNEKHGERYKVYNLCSERNYDtTKFYNRVAHYPF----DDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLyqT
..|.. .|.. . |.. .|   ..   ..  . |... |    ..  |     .  . ... .    .|...  ..|..| |||||. ... .||   | 
fkvtlkeeekladyiirklklskeks-segeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfialdsvlerl--k

ASEALDFYASKRT
| .| .   .|  
aeeeidvfevlkt

Phosphatase spur_PTEN-B.AA Subfamily.R_Anemone_2.PD 85-164 22 1.3e-06 19.4 In-house 168-247 (262) Show / Hide
Range on Protein: 85-164
Range on HMM: 168-247/262
Sequence Identity: 22% (19 aa)

DHNPPR--LELIKpFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTAseALDFYAS-KRTKNRKGVTIPSQ
|.. |    .|.. .  . ...    |... ..|| || ||||| |   .| .|. . |   .| .   |. .... . .  .
degvpesgaslld-lvrqvekaqqesgagpivvhcsaGvGrtGvfiavdillerikaea--lvdvfqtvkqlreqrnlmvqtk

Phosphatase spur_PTEN-B.AA Subfamily.RB.PD 44-147 18 1.7e-06 18.8 In-house 126-228 (261) Show / Hide
Range on Protein: 44-147
Range on HMM: 126-228/261
Sequence Identity: 18% (19 aa)

EVVVKFFNEKHGERYKVYNLCSERNYDtTKFYNRVAHYPFDDHNPPR-LELIKPFCEDLDNWLGAD-GQNVAAIHCKAGKGRTGVMICAYMLHRRLYQta
.. |.  .||. . . . ..  |.. . ..  ... .  . ||. |.  . .  |.. ..... ..  ..   .|| || ||||. |   .| ... .  
dikvtllaekeldewvirefkiekgke-krkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqaiee--

SEALDF
.. .| 
ndyvdv

Phosphatase spur_PTEN-B.AA Subfamily.N12.PD 57-148 22 1.9e-06 18.4 In-house 147-238 (270) Show / Hide
Range on Protein: 57-148
Range on HMM: 147-238/270
Sequence Identity: 22% (21 aa)

RYKVYNLCSERNYDTTKFYNrVAHYPFDDHN-PPRLELIKPFCEDLDNWLGaDGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTAS-EALDFY
. .  |  |.. .. |.|    .  . ||. | . . .  . |.. .  . . ..  ..|| || ||||..|   . .. | .    | ||.  
dflirtLkveaqkesrkvyq-fhytaWPDhgvPssaksllelielvrelqe-sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvf

Phosphatase spur_PTEN-B.AA Subfamily.N6.PD 45-152 23 4e-06 17.5 In-house 155-267 (295) Show / Hide
Range on Protein: 45-152
Range on HMM: 155-267/295
Sequence Identity: 23% (25 aa)

VVVKFFNEKHGERYKVYNLCSERNyDTTKFYNRVAHYPF---DDHNPP-RLELIKPFCEDLDNWLG-ADGQNVAAIHCKAGKGRTGVMICAYMLH-RRLY
. |.  .||. ..|.. ..  ... |. |   .. .| |    ||. |   . .  | ||...       .    .|| || |||| .|   ... .   
itvtsisEkstadYtlRefsvshk-dkdkeareifqyhfkaWPdhgvpkdpgvvlnfledvnkkqeelekagpivvhcsaGiGrtGtfividivlkiieq

QTASEALDFYASKR
.|.. | .      
sgldvdidisksik

Phosphatase spur_PTEN-B.AA Subfamily.DSP19.PD 110-146 24 5.3e-06 17.6 In-house 79-114 (139) Show / Hide
Range on Protein: 110-146
Range on HMM: 79-114/139
Sequence Identity: 24% (9 aa)

QNVAAIHCKAGKGRTGVMICAYMLHRRLYQtASEALD
...  .||.||  |.  .. ||.....  .  ..||.
dgrvlvHCnAGvSRsasvviaylmkdeels-lekale

Phosphatase spur_PTEN-B.AA Subfamily.RK.PD 59-167 15 6.1e-06 16.8 In-house 145-255 (267) Show / Hide
Range on Protein: 59-167
Range on HMM: 145-255/267
Sequence Identity: 15% (17 aa)

KVYNLCS-ERNYDTTKFYNRVAHYPFDDH--NPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLyQtASEALDFY-ASKRTK
......   |... ..  ... .  . ..   |   . .  .   ....   ...    .|| || ||.|. |   ..   . .   . .| .| |  .|
rifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidivlemi-e-regvvdvfnavktlr

NRKGVTIPSQRRY
||   .  . .| 
nrkvnmveteeqy

Phosphatase spur_PTEN-B.AA Subfamily.R_Ecdysozoa.PD 109-171 25 9.7e-06 16.1 In-house 200-261 (269) Show / Hide
Range on Protein: 109-171
Range on HMM: 200-261/269
Sequence Identity: 25% (16 aa)

GQNVAAIHCKAGKGRTGVMICAYMLHRRLYqtASEALDFYAS-KRTKNRKGVTIPSQRRYVEYY
.    .||.|| ||.|....  .|  .|   | . .| ..  |  .... . . | ..||  | 
srsPivvhCsaGvgrsgifvaldlllqqlk--aedkvdifetvkkLrsqrnllvqsleqyvfly

Sequence
Name Sequence Type Origin Length Description Download
spur_PTEN-B.AA Protein None 393 None Fasta, JSON
spur_PTEN-B.NA RNA None 1179 None Fasta, JSON
spur_PTEN-B.AA.PD_74-176 Protein Phosphatase Domain None 103 None Fasta, JSON