Gene spur_PTEN-A
spur_PTEN-A
Species: S.purpuratus
Alias: spur_PTEN-A
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_PTEN-A.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | spur_PTEN-A.AA | Subfamily.PTEN.PD | 1-250 | 36 | 1.5e-72 | 235.3 | In-house | 12-259 (305) | Show / Hide |
Range on Protein: 1-250 Range on HMM: 12-259/305 Sequence Identity: 36% (91 aa) MGFPAESLERMYRNDMEHVVKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVM ...|.|..|........ ....|.. .....|...|........| ||.|||.|||||||||..||.....||| .|| |||.||.|.|||||||||||| lsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavHCkaGkGRtGvm ICALLLHQGRCLTAAESMEYYGKIRTTDGKGVTIPSQRRYVQYYGELVKRNTLYKTQTVLLKRVQLYTIPMMS--SGTCCPFFTVHQHKVKIHTQEAVKG ||| ||..| . .| |....|.. ||.|.||||||||||||||. .||| . | .. . ... . |.|. .. . .| . icayLlksgikksadealaiydekRtkdkkGVtiPSQrRYvqYfsklvkssvpyskvslnvceirfsesscvqnlgmvecsisvlhdsatenakpdrlkt VKKGLS-CVEFELPHALPIRDDVKIEFYHKSGllkmdKRLMFHMWFNTYFIVH . .. . . ..|. |||.|. .|| ... |.|.||.|. lpidfqksfvltikpsipvsgdvkfeltkksp-----dkiichfwlntffvrn |
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| Phosphatase | spur_PTEN-A.AA | Family.DSP.PD | 9-248 | 22 | 6.8e-40 | 128.4 | In-house | 126-343 (387) | Show / Hide |
Range on Protein: 9-248 Range on HMM: 126-343/387 Sequence Identity: 22% (54 aa) ERMYRNDMEHVVKFLnshhqdhykvynlcsernYDTS----RFDHRVAHYPFDDHNPPRIELIrpFCEdVMQWLAE--DKDNVAAIHCKAGKGRTGVMIC | . .. . ..|. .| . . . .. ..|.||||.| .|.. |.. ..... | |. .|...||||||||.|..|. ewlkelgvtkivnlt------------------ddkpqftkelgikylripidDhnapplenl--fek-aidfieegndskgvVlVHCkaGkgRsgtlii ALLLHQgRCLTAAESMEYYGKIRttdgKGVTIPSQRrYVQYYGELVKRNTLYKTQTVLLKRVQLYTIPMMSSGTCCPFFTVHQHKVKIHTQEAVKGVKKG | |... . ||. |..... . | .||..|.|. ..... .| |.. ..... |..|. .. . | .. . . |. ... | . aYlmks-egltleealdwvrskR----pgvitpnqg-flkqlkdlekeklkvssevmelrfvissivqnlgsvevsvsvlkkvatekakldrlkiLvide LSCVEFELPHALPIRDDVKIEFYHKSgLLKMDKRLMFHMWFNTYFI | . .||. .|||.|...|. |.|. . ... ..|.| .| qekvvitikdglplsgDVkvelfkkn-ldkiirdiilntfFvtnyi |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.TPIP.PD | 47-249 | 35 | 9e-40 | 127.6 | In-house | 1-210 (245) | Show / Hide |
Range on Protein: 47-249 Range on HMM: 1-210/245 Sequence Identity: 35% (76 aa) FDHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLLHQGRCLTAAESMEYYGKIRTTDG-----KGVTIPSQRRYV |..|| . |||| |..| . |...| .|||.|..|| ||||| |||||| ..||||.. . .||| ||..|.|. || .|||||.|||.| fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv QYYGELVKRN--TLYKTQTVLLKRVQLYTIpmmsSGTCCPF--FTVHQHKVKIHT-QEAVKGVKKGLS--CVEFELPHALPIRDDVKIEFYhKSGLLKMD . .. . | . ...||. .|.| | | . | ..|| . . . . . . . .. . |. ||||..|. | | | gylaqvkhlynwnlpprrilfikrfiiysi----rgdvcdlkvqvvmekkvvfsstslgncsilhdietdkilinvydgpplyddvkvqff-ssnlpkyy KRLMFHMWFNTYFIV | .|||| || dncpfffwfntsfiq |
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| Phosphatase | spur_PTEN-A.AA | PTEN_C2 | 154-329 | 26 | 3.8e-35 | 127.85 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 154-329 Range on HMM: 1-141/141 Sequence Identity: 26% (49 aa) YKTQTVLLKRVQL-YTIPMM-SSGTC-CPFFTVHQHKVKI-HTQEAVKGVKKG--LSCVEFELPHALPIRDDVKIEFYHK--SGLLKMDKRLMFHMWFNT .. ... |... . ..||.. . |.| |.... |...|. .| . ...|| |. |..|. .|. .||||..||| | | .| . .||..|||| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVFYTCKKYWHCKKYKQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFWFNT YFIVHPIQPDKDYFGQARSHSRPTSTVSCPSPDQARAPFAEDEMLNGGEEFVLELHKDEIDKANKDKTNKVFSPNLKVKLFFAR .|| | .. .|.. |.|.|||.|||..| |.|. ||.. | . CFIEH-------------------------------------------NNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.Tensin.PD | 48-249 | 29 | 6.9e-30 | 95.0 | In-house | 2-205 (237) | Show / Hide |
Range on Protein: 48-249 Range on HMM: 2-205/237 Sequence Identity: 29% (60 aa) DHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLLHQGRCLTAAESMEYYGKIRTTDGK--GVTIPSQRRYVQYYG ...| . . |. | .| . |. . || | .|| ..||| ||||.||.|.| . .. . .| .... . | | | ||| |||||||.|. nekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrfyddkvsgvtqPsqrryveyfs ELVKRNTLYKTQTVLLKRVQLYTIPMMSS-GTCCPFFTVHQHKVKIHTQEAVKGVKKGLSCVEFELPHALPIRDDVKIEFYHKSGlLKMDKRLMFHMWFN .|.. . ... ..|. | | .|| . | |.| ||. ..| ..| . .. . . . || .. || ..||| .. ..| . | | gllsgsiklnssplflhyvilhgipnfdskggcrpflkiyqalqlvytsgvynvagedterlcitiepalllkgdvlvkcyhkkl-rsttrdvvfrvqfh TYFIV | tgaik |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.PRL.PD | 16-113 | 27 | 5.3e-14 | 43.1 | In-house | 11-111 (140) | Show / Hide |
Range on Protein: 16-113 Range on HMM: 11-111/140 Sequence Identity: 27% (26 aa) MEHVVKFLNSHHQDHYKVYNLCSERNYDTSRF---DHRVAHYPFDDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLLHQGRCL | | ||.. .... | . | .||.... . .| ..||| ..| |... . | ... .|..... |.|| || ||. |... |. .| detvekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGmky T e |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.CDC14.PD | 11-140 | 27 | 2.6e-11 | 34.5 | In-house | 143-250 (258) | Show / Hide |
Range on Protein: 11-140 Range on HMM: 143-250/258 Sequence Identity: 27% (35 aa) MYRNDMEHVVKfLNSHhqdhykvynLCSERNYDTSRFDHRvaHYPFDDHNPPRIELIRPFCEdvmqwLAEDKDNVAAIHCKAGKGRTGVMICALLLHQGR .|.....|. ||.. | ..... |.| | | | .... | | ..|. . .|.||||| ||||..|. |... | .| frknnvttivr-Lnkk---------lYdakkftdaGfahl--DlffiDGtvPsdailkkfle-----itekaeGaiavhCkaGLGrtgtligcylikhyr cLTAAESMEYYGKIRTtdgkGVTIPSQRRY |||.. . .| | | |. | -ftaaetiawlriarP----Gsvigpqqty |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.DSP23.PD | 56-123 | 26 | 3.4e-10 | 30.9 | In-house | 41-105 (128) | Show / Hide |
Range on Protein: 56-123 Range on HMM: 41-105/128 Sequence Identity: 26% (18 aa) FDDHNPPRIELIRPFCEdVMQwLAEDKDNVAAIHCKAGKGRTGVMICALLLHQgRCLTAAESMEYYGK .|. || .| . . . ... ||.|.. ..|| | |||| .. |... . |.|.... | ipdfcPPaleqvarlvr-ive-eaekkeeavgvhcalGlGrtGtllacylvke-eglaaddaiaevrk |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.PTPDC1.PD | 54-119 | 31 | 7.2e-10 | 29.5 | In-house | 140-201 (229) | Show / Hide |
Range on Protein: 54-119 Range on HMM: 140-201/229 Sequence Identity: 31% (21 aa) YPFDDHNPPRIELIRPFCEdVMQWLAedKDNVAAIHCKAGKGRTGVMICALLLHQGRcLTAAESME ....|.. . .| | |.. .. |.|| ||.|||||.|.. |... | |||.|... fglkDygvasleriLdivk-vvdfal--eegkiavHCHAGlGRtGvliacylvyakr-ltaeeaik |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.DSP11.PD | 39-125 | 25 | 9.3e-10 | 29.3 | In-house | 32-122 (141) | Show / Hide |
Range on Protein: 39-125 Range on HMM: 32-122/141 Sequence Identity: 25% (23 aa) ERNYDTSRFDHR-VAHYP--FDDHNPPRIELIRPFCEDVMQWL--AEDKDNVAAIHCKAGKGRTGVMICALLLHQgRCLTAAESMEYYGKIR .| |... . .. | .. |. | | .. |.| | ..| .|.|.. ..|| | ||| .|| |... . . ...| . ..| dryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidv-egyspedaieafeear |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.N5_RR.PD | 10-104 | 22 | 2.2e-08 | 24.6 | In-house | 121-218 (265) | Show / Hide |
Range on Protein: 10-104 Range on HMM: 121-218/265 Sequence Identity: 22% (22 aa) RMYRNDMEHVVKFLNSHHQDHYKVYNLCSERNYDtsrFDHRVAHYPF----DDHNPPRIELIRPFCEDVMQWLAEDKDNVA--AIHCKAGKGRTGVMICA .. . .. .|. . ....|.| .| . . ..| || . | . | .|. . ....| . |.. ..| .|| ||||||..|... eiserygdveikveeiverndysvrklvlkyler---versvkhywytdWPdhksPddintlldlvleveesreeenaklaPvvvhcsaGiGrtGcfiai L s |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.RNGTT.PD | 17-123 | 22 | 2.9e-08 | 24.4 | In-house | 8-118 (140) | Show / Hide |
Range on Protein: 17-123 Range on HMM: 8-118/140 Sequence Identity: 22% (25 aa) EHVVKFLNSHHQDHYKVYNLC-SERNYDTSRFDHR-VAHYPFD--D-HNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLLHQGRC | ....|..... | .| .| || . .... | . .. . | | .. | . | ..| . |.| ..|| | ||| .|.| |... . emlksylktlkvklglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedw lTAAESMEYYGK . .... . | -sveaavalfak |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.RB.PD | 20-106 | 22 | 2.4e-07 | 21.3 | In-house | 129-216 (261) | Show / Hide |
Range on Protein: 20-106 Range on HMM: 129-216/261 Sequence Identity: 22% (20 aa) VKFLNSHHQDHYKVYNLCSERNYDtSRFDHRVAHYPFDDHNPP-RIELIRPFCEDVMQWLAED-KDNVAAIHCKAGKGRTGVMICALLL |. |.....|.. . .. |.. . .| ... . . ||. | . . . |.. | ... .. ... .|| || ||||. | | vtllaekeldewvirefkiekgke-krkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrl |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.R_Sponge_2.PD | 18-127 | 18 | 3.1e-07 | 21.0 | In-house | 126-236 (262) | Show / Hide |
Range on Protein: 18-127 Range on HMM: 126-236/262 Sequence Identity: 18% (20 aa) HVVKFLNSHHQDHYKVYNLCSERNYDtSRFDHRVAHYPF----DDHNPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICALLlHQGRcLT .|.. .... .|.. .| .. | .. |... | .. | . . ..|.. ...... ..|..| |||||. . | | | | fkvtlkeeekladyiirklklskeks-segeadvtqfhfvaWpehevPkdatsllelikrvlraqkksgnkaitvvCsdgvgrtGtfialds-vler-lk AAESMEYYGKIRTT ... . ..| aeeeidvfevlktl |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.PTPMT1.PD | 58-119 | 22 | 1e-06 | 19.5 | In-house | 62-121 (146) | Show / Hide |
Range on Protein: 58-119 Range on HMM: 62-121/146 Sequence Identity: 22% (14 aa) DHNP-PRIELIRPFCEdVMQWLAEDKDNVaAIHCKAGKGRTGVMICALLLHQGRClTAAESME |. | | .. | ... |.....| .|||||..| . .. . |... .. .. |... Dfteapslekleegve-fiekvaskgssv-YvHCkAGrtRsatlvacylmkkkkl-speeavk |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.R_Anemone_2.PD | 20-103 | 22 | 1.4e-06 | 18.9 | In-house | 129-214 (262) | Show / Hide |
Range on Protein: 20-103 Range on HMM: 129-214/262 Sequence Identity: 22% (19 aa) VKFLNSHHQDHYKVYNLCSERN-YDTSRFDHRVAHYPFDDHNPPR--IELIrPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMICA |. .. . ..| . .. .|. . .| .. . . |.. | .|. . .| .. .| . .. ..|| || ||||| | velkeevelsdyvlrsfkvkrteeeeerqvrqfhytsWpdegvpesgasll-dlvrqvekaqqesgagpivvhcsaGvGrtGvfiav |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.N12.PD | 28-103 | 29 | 1.5e-06 | 18.4 | In-house | 145-218 (270) | Show / Hide |
Range on Protein: 28-103 Range on HMM: 145-218/270 Sequence Identity: 29% (23 aa) QDHYKVYNLCSERNyDTSRFDHRVAHYPFDDHNPP-RIELIRPFCEDVmQWLAEDKDNVAAIHCKAGKGRTGVmICA .| . . | |.. ..|| .. . . ||. | ... . . |.| . | |..|. ..|| || ||||. |.| dddflirtLkveaq-kesrkvyqfhytaWPDhgvPssaksllelielv-relqesedaPlvvhCsaGvGrtGt-iia |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.N13.PD | 20-103 | 30 | 3.1e-06 | 17.7 | In-house | 128-211 (259) | Show / Hide |
Range on Protein: 20-103 Range on HMM: 128-211/259 Sequence Identity: 30% (27 aa) VKFLNSHHQDHYKVYNLCSERNydTSRFDHRVAHYPF---DDHNPPR--IELIRPFCEdvMQWLAEDKDNVaAIHCKAGKGRTGVMICA |. |. ..| ..| .| . . |. ..||| | ||. |. .||.. .| .. |..|. . ..|| || ||.||.|. vellkvqkldgfvvralavkds--esgesrevahlnfvkwPdhgvPssaaelvqfvae--vrllqtdagPi-vvhcsaGiGrsGvliti |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.N_Choan_1.PD | 20-102 | 27 | 4.4e-06 | 17.1 | In-house | 129-212 (262) | Show / Hide |
Range on Protein: 20-102 Range on HMM: 129-212/262 Sequence Identity: 27% (23 aa) VKFLNSHHQDHYKVYNLCSERNYDTSRFDHRVAHYPFDDHNPPR-IELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMIC ||.|..... .| .. ||. .| ...|. . || | . . | ..|.. .... ||| || ||||. | vkslseeekktyierkfkleresgetreveqlaytaWPdhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGtyia |
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| Phosphatase | spur_PTEN-A.AA | Subfamily.RK.PD | 32-102 | 17 | 5.6e-06 | 16.5 | In-house | 145-218 (267) | Show / Hide |
Range on Protein: 32-102 Range on HMM: 145-218/267 Sequence Identity: 17% (13 aa) KVYNLCS-ERNYDTSRFDHRVAHYPFDDH--NPPRIELIRPFCEDVMQWLAEDKDNVAAIHCKAGKGRTGVMIC ...... |... | ... . . .. | . . . | .. .|... .|| || ||.|. | rifrveklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfia |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| spur_PTEN-A.AA | Protein | None | 382 | None | Fasta, JSON |
| spur_PTEN-A.NA | RNA | None | 1146 | None | Fasta, JSON |
| spur_PTEN-A.AA.PD_47-149 | Protein Phosphatase Domain | None | 103 | None | Fasta, JSON |