Gene spur_TPIP
spur_TPIP
Species: S.purpuratus
Alias: spur_TPIP
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_TPIP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | spur_TPIP.AA | Family.DSP.PD | 14-344 | 23 | 1.2e-49 | 160.7 | In-house | 73-379 (387) | Show / Hide |
Range on Protein: 14-344 Range on HMM: 73-379/387 Sequence Identity: 23% (76 aa) KASRKLVSENKRRYLQDGFDLDlTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLCSERHYdESY-FNHQVIRVQTDDHNVPKLEEL |.....| .. |||| || .. . || ...| . . .. . . |. . |..||. ... ... . ...|.. ||||.|.||.| visgakqaelngfidvhtfdld-tydhfervengkpseilphlylgsllaaknlewlkelgvtkivnltddkpq-ftkelgikylripidDhnapplenl lkFSKIAKeWMEA--DPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAkECLDFFGSRRtdldegdkfQGVQTPSQSrYVHYFEQVKFKYGGQipEPKD | |. . ..| |.|.| ..|||.||||.|| .. .|..|| . |.||.. |.| .|| ||.| ....... ... . . .... --fekaid-fieegndskgvVlVHCkaGkgRsgtliiaYlmksegltle-ealdwvrskR---------pgvitpnqg-flkqlkdlekeklkv--ssev LIIENIRIRnlaglGKGDGRDLYFEIICsnKKVFDCRFENGLNCQSIYDHASDSLSARIPHCPVLHGDVKIRFKSSSrkVPEDYDNCAFFFWFHTAFITD .. . .. .. . |. . ... . . ... | ..|.||||... ... . ........|.| .| |..| | melrfviss-----ivqnlgsvevsvsv--lkkvatekakldrlkiLvideqekvvitikdglplsgDVkvelfkkn--ldkiirdiilntfFvtnyikd NRLFLPRDELDNPHKSKARKIYSESFNVEVQFSE .. |||..||||. ..| .|. ||. . . eslvlvkkeldelhkskifdvykdseaveiseef |
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| Phosphatase | spur_TPIP.AA | Subfamily.TPIP.PD | 92-344 | 49 | 1.8e-94 | 306.9 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 92-344 Range on HMM: 1-245/245 Sequence Identity: 49% (126 aa) FNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTDLDEGDKFQGVQTPSQSRYV |...| |...||||||.||||..|.| .|||...|..||..||||||||||||.||..|..||.|.||.|.||.||.|||| ....|||||.||||.||| fhnrvsrimiddhnvPtleelvvftkevkewlakdlenvvaihckGGkgrtGtivcalliaseifltaeesldyfgerrtdkthsnkfqGvetPsqnryv HYFEQVKFKYGGQIPEPKDLIIENIRIRNLaglgKGDGRDLYFEIICSNKKVFDCRfeNGLNCQSIYDHASDSLSARIPHCPVLHGDVKIRFKSSsrKVP .|..||| | ..| . |.|. . | .. .|| || ... .| || . . || ..| .| . . | |. |||..| || ..| gylaqvkhlynwnlpprrilfikrfiiysi----rgdvcdlkvqvvmekkvvfsst--slgncsilhdietdkilinvydgpplyddvkvqffss--nlp EDYDNCAFFFWFHTAFITDNRLFLPRDELDNPHKSKARKIYSESFNVEVQFSE . |||| ||||| |.|| .||| |||.||||||| || ||| | ||. |.| kyydncpfffwfntsfiqnnrlclprneldnphkqkawkiyppefaveilfge |
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| Phosphatase | spur_TPIP.AA | Subfamily.PTEN.PD | 35-342 | 28 | 2.5e-47 | 152.7 | In-house | 1-303 (305) | Show / Hide |
Range on Protein: 35-342 Range on HMM: 1-303/305 Sequence Identity: 28% (90 aa) DLTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLCSERHYDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPKNVMFIH |..|. .|. |.| . .... . .. ..|.|.. ...|. .|........| |...|. . |||| |.|| | .. . ..|...|.||. .|| disyilvnlivlsypvetyekllyrnslddlillltvykgkgklrilnargekedsdfdgrvavypfdDhnpptleLleeivedvdkwLkedksnVvavH CKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTDLDegdkfQGVQTPSQSRYVHYFEQVKFkygGQIPEPK-DLIIENIRIRNLAGLgkgdgRDLy | ||||||. .|..||.| ...|.| |..... || .|| ||| |||.||... .| | | . .||. . . . ..| CkaGkGRtGvmicayLlksgikksadealaiydekRtkdk-----kGVtiPSQrRYvqYfsklvk---ssvpyskvslnvceirfsesscv-----qnl- FEIICSNKKVFDCRFENG----LNCQSIYDHASDSLsARIPHCPVlHGDVKIRF-KSSSRKVPEDYDNCAFFFWFHTAFITDNR-----LFLPRDELDNP . || ..|. || |. | . | | . | || ||||. . | | |. . .|| .. .| | . |.|. | gmvecsisvlhdsatenakpdrlktlpidfqksfvl-tikpsipv-sgdvkfeltkkspdkiichfwlntffvrnyspcesdgtvnkyihtlskseiddv HKSKARKIYSESFNVEVQF | .| .|| |.. . | hkdsehkrfseefkisivf |
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| Phosphatase | spur_TPIP.AA | PTEN_C2 | 206-344 | 31 | 2.9e-32 | 117.57 | Pfam | 1-141 (141) | Show / Hide |
Range on Protein: 206-344 Range on HMM: 1-141/141 Sequence Identity: 31% (46 aa) PEPKDLIIENIRI-RNLAGLGKGDGR-DLYFEIICSNKKVFDCRFENGLNCQSIYDHASDSLSARIPHCPVLHGDVKIRFKSSS-RKVPEDYDNCAFFFW | || | . |.. . . ..|.| ..|..|.. ..||| .. ... .| . .. .|.. ...|||||...... . | |..| |.|| PPPKPLFLHCIIMDHGIPNFKQGGGCWRPYIQIYQNDQKVF--YTCKKYWHCKKY-KQQKCCIFKFPQPCPVQGDVKIQCYHKGPSDLPWMYEECMFRFW FHTAFIT--DNRLFLPRDELDNPHKSKARKIYSESFNVEVQFSE |.|.|| .||| .|..|||...| |. |.... | |||.||| FNTCFIEHNNNRLTFPKNELDKAWKDKKWKRFPPDFKVEVVFSE |
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| Phosphatase | spur_TPIP.AA | Subfamily.Tensin.PD | 92-343 | 27 | 6.7e-30 | 95.3 | In-house | 1-236 (237) | Show / Hide |
Range on Protein: 92-343 Range on HMM: 1-236/237 Sequence Identity: 27% (69 aa) FNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTdLDegDKFQGVQTPSQSRYV .|..| . |. | || | | . |..|||.||. .||||||||.| ..... |. ..|...|| | .| .| || .||. ||| ||| lnekvldlGWPdllaPpleklcsickalesWlkadpqnvvvlhckGgkGrigvvisaymhyskisasadaaldrfalkrf-yd--dkvsgvtqPsqrryv HYFEQVKFkYGGQIpEPKDLIIENIRIRNLAGLGKGDGRDLYFEIICSNKKVFDCrfenGLncQSIYDHASDSLSARIPHCPVLHGDVKIRFksSSRKVP .||... .. . . |.. . .. . . | .. | . . |. |. .. . ...| |. .|.||| .. .|. eyfsglls-gsikl-nssplflhyvilhgipnfdskggcrpflkiyqalqlvyts----gv--ynvagedterlcitiepalllkgdvlvkc--yhkklr EDYDNCAFFFWFHTAFITDNRLFLPRDELDNPHKSKArkiYSESFNVEVQFS . | |||. |.| .| .....||. .| . . | .||. || sttrdvvfrvqfhtgaikdlklvfekedldealkder---fpeyakvelvfs |
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| Phosphatase | spur_TPIP.AA | Subfamily.RNGTT.PD | 66-170 | 26 | 2.2e-12 | 37.9 | In-house | 12-120 (140) | Show / Hide |
Range on Protein: 66-170 Range on HMM: 12-120/140 Sequence Identity: 26% (29 aa) RFLNTKHPDHYKVINLC-SERHYDESYFNHQ---VIRVQTDDH-NVPKLEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAk .|.|.. ||.| .|.||.. .... |..| . . |. |. .| |. ||... |..|. .|| | ||| ....|.| | .. . sylktlkvklglvidltntsryydkeelekegvkyiklqcrGrGeaPtkeqtklfiklvkeflkkkPdevigvhCthGfnrtGflivayLvekedwsve- ECLDFFGSRR .. | . | aavalfakar |
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| Phosphatase | spur_TPIP.AA | Subfamily.DSP11.PD | 78-171 | 26 | 6.5e-12 | 36.5 | In-house | 25-123 (141) | Show / Hide |
Range on Protein: 78-171 Range on HMM: 25-123/141 Sequence Identity: 26% (26 aa) VINLC-SERHYDESYFNHQV---IRVQTDDHNVPKLEELLKFSKIAKEWME--ADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTaKECLDFFGSRRT ||.| .|.|... .... .... |.||. |.. ||.. ||..| .| .... .|| | ||| .| .|.. | ... .... | . | vidltntdryykkkeltdegvkykklncpGhevpekedvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegysp-edaieafeearG |
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| Phosphatase | spur_TPIP.AA | Subfamily.PTPMT1.PD | 95-172 | 22 | 4.2e-10 | 30.6 | In-house | 54-129 (146) | Show / Hide |
Range on Protein: 95-172 Range on HMM: 54-129/146 Sequence Identity: 22% (17 aa) QVIRVQTDD-HNVPKLEELLKFSKIAKEWMEAdpKNVMFIHCKGGKGRTGTAVCTWLLESEAFQtAKECLDFFGSRRTD . ... | | ..|.||.| . .. .. .. .. ...||| |..| .| | ..|.... .. ..| .|. ..| eqlqlatvDfteapslekleegvefiekvask--gssvYvHCkAGrtRsatlvacylmkkkkls-peeavkflkkkRpq |
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| Phosphatase | spur_TPIP.AA | Subfamily.DSP23.PD | 79-160 | 25 | 5.5e-10 | 30.5 | In-house | 18-98 (128) | Show / Hide |
Range on Protein: 79-160 Range on HMM: 18-98/128 Sequence Identity: 25% (21 aa) INLCSE-RHYDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADpkNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAK ..| | . | |. . . |.. .|. | || . .. .| .| . . . . .|| | ||||| . .|...| . ... vslttegapyseaapsltlrridipdfcPPaleqvarlvriveeaekke--eavgvhcalGlGrtGtllacylvkeeglaadd |
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| Phosphatase | spur_TPIP.AA | Subfamily.PTPDC1.PD | 98-195 | 25 | 1.6e-09 | 28.6 | In-house | 139-224 (229) | Show / Hide |
Range on Protein: 98-195 Range on HMM: 139-224/229 Sequence Identity: 25% (24 aa) RVQTDDHNVPKLEELLKFSKIAKEWMeadPKNVMFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDFFGSRRTDldegdkfqGVQTPSQSRYVHYFE . .|..|. ||..| |... . . . .|| |.|||| ....|. .. . ||.| ... |.|.. .|| .|. |. |. nfglkDygvasleriLdivkvvdfal---eegkiavHCHAGlGRtGvliacylvyakrl-taeeaiklvrskrpk--------siqtreqvelveeFa |
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| Phosphatase | spur_TPIP.AA | Subfamily.PRL.PD | 64-170 | 25 | 1.1e-08 | 26.0 | In-house | 14-121 (140) | Show / Hide |
Range on Protein: 64-170 Range on HMM: 14-121/140 Sequence Identity: 25% (27 aa) VSRFLNTKHPDHYKVINLCSERHYDESYFNHQVIRV---QTDDHNVPKLEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLLESEAfqTAK |..|... . .. | . . | || . .... |.| . || .|| | . .. .. || . .||... .|| | ||. |. |.|.. .. .. vekfieelkkenvkevvrvcepsydaeklkeegievldlafddGavPpkevvdeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm--kye ECLDFFGSRR | ..| davefirekr |
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| Phosphatase | spur_TPIP.AA | Subfamily.CDC14.PD | 83-165 | 28 | 2.2e-08 | 25.1 | In-house | 160-234 (258) | Show / Hide |
Range on Protein: 83-165 Range on HMM: 160-234/258 Sequence Identity: 28% (23 aa) SERHYDESYFNHQVIrvQTDDHNVPKLEELLKFSKIAKEWmeadpKNVMFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDF ...... |.|. . | ||. . | || .|. . . . .||| | ||||| . ..|. | ||.|.. . dakkftdaGfahlDl--ffiDGtvPsdailkkfleiteka-----eGaiavhCkaGLGrtgtligcylikhyrf-taaetiaw |
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| Phosphatase | spur_TPIP.AA | Subfamily.RB.PD | 71-167 | 27 | 9.1e-08 | 22.8 | In-house | 135-230 (261) | Show / Hide |
Range on Protein: 71-167 Range on HMM: 135-230/261 Sequence Identity: 27% (27 aa) KHPDHYKVINLCSERhYDESYFNHQVIRVQTDDHNVPKL-EELLKFSKIAKEWMEAD-PKNVMFIHCKGGKGRTGTAVCTWLLESEAFQtaKECLDFFG |. |.. . .. |. .|. .|. . ||.||. . ||.| . .|..|.. |. . .|| | ||||| . | . . ....| || keldewvirefkiek-gkekrkvrqyhftsWpdhgvPektktlldfvrtvreaiekkaskkPivvHCsaGvGRtGtfialdrllqaiee--ndyvdvfg |
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| Phosphatase | spur_TPIP.AA | Subfamily.N12.PD | 76-167 | 26 | 1.4e-07 | 22.0 | In-house | 148-239 (270) | Show / Hide |
Range on Protein: 76-167 Range on HMM: 148-239/270 Sequence Identity: 26% (25 aa) YKVINLCSERHyDESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEADPkNVMFIHCKGGKGRTGTAVCTWLLE-SEAFQTAKECLDFFG . . | |.. .|| .| . ||.||. ..||.. . ..| |.. . . .|| | ||||| . . .. .|.|| | flirtLkveaq-kesrkvyqfhytaWPDhgvPssaksllelielvrelqesed-aPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfd |
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| Phosphatase | spur_TPIP.AA | Subfamily.N_Choan_1.PD | 100-149 | 39 | 2.7e-07 | 21.3 | In-house | 164-214 (262) | Show / Hide |
Range on Protein: 100-149 Range on HMM: 164-214/262 Sequence Identity: 39% (19 aa) QTDDHNVPK-LEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTW . || ||. .|||.| | .. . . | . ||| | ||||| . aWPdhGvPattkellefrkavlkatkkktkaplvihCsaGvGrtGtyialD |
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| Phosphatase | spur_TPIP.AA | Subfamily.RK.PD | 82-192 | 23 | 1.1e-06 | 19.0 | In-house | 150-259 (267) | Show / Hide |
Range on Protein: 82-192 Range on HMM: 150-259/267 Sequence Identity: 23% (27 aa) CS-ERHYDESYFNHQVIRVQTDDH-NVPKL-EELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAV-CTWLLEseaFQTAKECLDFFGSRRTDLDegD . | ..| .|. .. .. .||. . |||. . |.. | . . . .|| | ||.|| . .. .|| .. .| | .|. | eklargqeeirevrqfqflgWpeyrdvPvskrsllklirrvkksqeeeeeGrivvhClaGaGrsGtfiaidivle---mieregvvdvfnavktlrn--r KFQGVQTPSQSRYVH |.| | ..|. kvnmveteeqykfvy |
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| Phosphatase | spur_TPIP.AA | Subfamily.R_Anemone_2.PD | 88-151 | 23 | 1.6e-06 | 18.9 | In-house | 153-217 (262) | Show / Hide |
Range on Protein: 88-151 Range on HMM: 153-217/262 Sequence Identity: 23% (15 aa) DESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLL .|. .| . |..||. .||.. . .... . .... .|| .| ||||. . | eeerqvrqfhytsWpdegvpesgaslldlvrqvekaqqesgagpivvhcsaGvGrtGvfiavdil |
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| Phosphatase | spur_TPIP.AA | Subfamily.DSP19.PD | 111-160 | 25 | 5.6e-06 | 17.3 | In-house | 60-111 (139) | Show / Hide |
Range on Protein: 111-160 Range on HMM: 60-111/139 Sequence Identity: 25% (13 aa) ELLKFSKIAKEWMEADPK--NVMFIHCKGGKGRTGTAVCTWLLESEAFQTAK .||.. | | ...| . .....||. | |. . | ..|...| .. | kllsylkealdFieearskdgrvlvHCnAGvSRsasvviaylmkdeelslek |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| spur_TPIP.AA | Protein | None | 351 | None | Fasta, JSON |
| spur_TPIP.NA | RNA | None | 1053 | None | Fasta, JSON |
| spur_TPIP.AA.PD_92-195 | Protein Phosphatase Domain | None | 104 | None | Fasta, JSON |