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Gene Spur_hmm90253,hmm225577

Spur_hmm90253,hmm225577
Species: S.purpuratus
Alias: Spur_hmm90253,hmm225577
External Links:
Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Superfamily: Cx5R-I
Family: Myotubularin
Subfamily: MTMR1
Protein domain

Protein domains of Spur_hmm90253,hmm225577.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
GRAM Spur_hmm90253,hmm225577.AA GRAM 101-172 21 1.3e-10 42.53 SMART 1-80 (80) Show / Hide 
Range on Protein: 101-172
Range on HMM: 1-80/80
Sequence Identity: 21% (18 aa)

SKLSQPEEIPLLLGERIEGI-AKDVTYLCPFIG----PSRGTLTITNYKLYFKGGDREPPF-----ILDVPLGAVYRVEKVG
.|. |.    |. .|.. .  .|.||| |....    |  |.. |.|....|.. .   .       ...|.. . |.||..
EKFRQHFK--LPPNEKLINDCKKEVTYSCYLWRTYDIPVQGHMYISNNHICFCSNMFGWMTCPQYYKVVIPWADITRIEKMT
Myotub-related Spur_hmm90253,hmm225577.AA Myotub-related 267-384 54 1.2e-68 239.19 Pfam 1-121 (121) Show / Hide 
Range on Protein: 267-384
Range on HMM: 1-121/121
Sequence Identity: 54% (66 aa)

FTFCDTYPAVLAIPAAADDELLRQVAAFRSRNRLPIMSWLHPQSQATITRCSQPLVGVGGKRSKEDEKYVQMILDANA---QSHKLVIMDARPTVNAVAN
...|.|||| | .|....|. |..||.|||..|.|  .|.|....|.|.||||||||. |.|.|||||.|| |..|||   ||.|..|.|||| .||.||
YEICPTYPAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRCSQPLVGWWGWRCKEDEKLVQAIMKANADMIQSRKMYIVDARPYTNAMAN

KAKGGGYENEDTYQNAEICFL
.|||||||||. |.|.|..|.
RAKGGGYENEEHYPNWEFVFM
GRAM Spur_hmm90253,hmm225577.AA GRAM 110-172 25 1.1e-09 37.66 Pfam 10-78 (78) Show / Hide 
Range on Protein: 110-172
Range on HMM: 10-78/78
Sequence Identity: 25% (18 aa)

PLLLGERIEGIAKDVTYLCPFIG-----PSRGTLTITNYKLYFKGGDREPPF--ILDVPLGAVYRVEKVG
||. .|.. . .. ||| |....     |  |...|||. ..|.. .  ...   ...|.... ||||..
PLPPNEKLIMDCN-VTYSCCLWRPFTKIPVQGRMYITNHHVCFYSDKFGWETYYKMVIPWNDITRVEKMQ
Phosphatase Spur_hmm90253,hmm225577.AA Subfamily.MTMR1.PD 398-546 79 1.3e-92 296.9 In-house 1-149 (149) Show / Hide 
Range on Protein: 398-546
Range on HMM: 1-149/149
Sequence Identity: 79% (119 aa)

KLKDICFPSIDEHHWLANLEATHWLEHVKMVLAGAVRIAERVEGQKTSVVVHCSDGWDRTAQLTALAMLLLDPYYRTIRGFEVLIEKEWLACGHKMAQRH
|||.|..|||||..||..||.|.||||.|..||||||||..|| .|||||||||||||||||||.|||||||.|||||.|||||||||||..|||.|.|.
klkeivypsideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaeri

GHGDKNYTDADRSPIFQQFIDCVWQVTRQFPNAFEFNEHFLITILDHLY
||||||..||||||.|.||||||||||||||.||||||.||||||||||
ghgdknhadadrspvflqfidcvwqvtrqfptafefneeflitildhly
Phosphatase Spur_hmm90253,hmm225577.AA Family.Myotubularin.PD 407-546 70 5.5e-73 232.9 In-house 2-141 (141) Show / Hide 
Range on Protein: 407-546
Range on HMM: 2-141/141
Sequence Identity: 70% (99 aa)

IDEHHWLANLEATHWLEHVKMVLAGAVRIAERVEGQKTSVVVHCSDGWDRTAQLTALAMLLLDPYYRTIRGFEVLIEKEWLACGHKMAQRHGHGDKNYTD
..|..||..||.|.||||.|..|..||.|.|.|| .||||.||||||||||||||.||.||||||||||.|||||||||||..|||.|.|.|||||....
aeekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksese

ADRSPIFQQFIDCVWQVTRQFPNAFEFNEHFLITILDHLY
..|||.|.||||||.|.|.|||.||||||.|||.||||||
eersPvflqfidcvyqltkqfptafefnesflikildhly
Phosphatase Spur_hmm90253,hmm225577.AA Subfamily.C2-MTMR1.PD 409-544 55 1.1e-57 183.5 In-house 3-135 (137) Show / Hide 
Range on Protein: 409-544
Range on HMM: 3-135/137
Sequence Identity: 55% (76 aa)

EHHWLANLEATHWLEHVKMVLAGAVRIAERVEGQKTSVVVHCSDGWDRTAQLTALAMLLLDPYYRTIRGFEVLIEKEWLACGHKMAQRHGHGDknyTDAD
. .||..||.|.|| ..| || .|  ||  ||    | .||||||||||.||..|| |||||||||| |. ||||||||| |||. .|.|. |   . ..
dvqwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggad---svse

RSPIFQQFIDCVWQVTRQFPNAFEFNEHFLITILDH
||||| ||.||..|||.||| |||.. ..|. . |.
rspiflqfldclyqvtkqfpsafeytarlllklady
Phosphatase Spur_hmm90253,hmm225577.AA Subfamily.MTMR3.PD 412-546 52 4.6e-56 178.1 In-house 1-135 (135) Show / Hide 
Range on Protein: 412-546
Range on HMM: 1-135/135
Sequence Identity: 52% (71 aa)

WLANLEATHWLEHVKMVLAGAVRIAERVEGQKTSVVVHCSDGWDRTAQLTALAMLLLDPYYRTIRGFEVLIEKEWLACGHKMAQRHGHGDKNYTDADRSP
.|..||.|.||.|. ..|  ||.... |. ..  |.||||||||||.|..||| |||||||||..||.||.|.|||  |||.|.| |||...    .|.|
flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp

IFQQFIDCVWQVTRQFPNAFEFNEHFLITILDHLY
.| |..|||.|...||| .||||| ||. ...| |
vflqwldcvhqlkkqfptsfefneaflvklvqhty
Phosphatase Spur_hmm90253,hmm225577.AA PTPc_motif 398-546 11 2.6e-08 34.86 SMART 1-92 (92) Show / Hide 
Range on Protein: 398-546
Range on HMM: 1-92/92
Sequence Identity: 11% (18 aa)

KLKDICFPSIDEH-----HWLANLEATHWLEHVKMVLAGAVRIAERVEGQKTSVVVHCSDGWDRTAQLTALAMLLLDPYYRTIRGFEVLIEKEWLACGHK
...   ...  .|     .        ....||.                  ..|||||.|..||... |. |.. .                       
TVHHYHYTNWPDHVEKDSGVPE-DSILEFIRHVRK-----------------PIVVHCSAGCGRTGTFCAIDMMMQQ-----------------------

MAQRHGHGDKNYTDADRSPIFQQFIDCVWQVTRQFPNAFEFNEHFLITILDHLY
                       . ..|...  | |.... .| ..  .  .|.
---------------------VDIFQTVKEMRKQRPGMVQTEEQYIFCYRCILE
Phosphatase Spur_hmm90253,hmm225577.AA Subfamily.R_Nematode_3.PD 430-463 54 5.9e-08 21.7 In-house 185-218 (267) Show / Hide 
Range on Protein: 430-463
Range on HMM: 185-218/267
Sequence Identity: 54% (17 aa)

AGAVRIAERVEGQKTSVVVHCSDGWDRTAQLTAL
|. ... ||  ||.||||||||  |.| | |   
kealelikfveksktpvvVHCsdGisRsatlaai
Sequence
Name Sequence Type Origin Length Description Download
Spur_hmm90253,hmm225577.AA Protein None 678 None Fasta, JSON
Spur_hmm90253,hmm225577.NA RNA None 2034 None Fasta, JSON
Spur_hmm90253,hmm225577.AA.PD_398-546 Protein Phosphatase Domain None 149 None Fasta, JSON