Gene Spur_hmm30030,hmm264741,hmm83000,hmm332945
Spur_hmm30030,hmm264741,hmm83000,hmm332945
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of Spur_hmm30030,hmm264741,hmm83000,hmm332945.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Myotub-related | Spur_hmm30030,hmm264741,hmm83000,hmm332945.AA | Myotub-related | 2-44 | 40 | 1.2e-07 | 31.43 | Pfam | 8-51 (121) | Show / Hide |
Range on Protein: 2-44 Range on HMM: 8-51/121 Sequence Identity: 40% (18 aa) PEFFVVPDPCSDYELKKASTNFEDCRVPFWCWSH-RNGSMLMRM |. .||| .|| |||| .. . .|.| .|| | .||. ..|. PAKLVVPKSISDDELKKVAKFRSWGRFPVLCWRHQENGAVICRC |
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| Phosphatase | Spur_hmm30030,hmm264741,hmm83000,hmm332945.AA | Family.Myotubularin.PD | 110-245 | 41 | 8.9e-42 | 130.4 | In-house | 2-139 (141) | Show / Hide |
Range on Protein: 110-245 Range on HMM: 2-139/141 Sequence Identity: 41% (57 aa) TTDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDRCGHCVPS--S ....||.|.|.|||||. | . |. |.. .... ...|.. | | | . ..||.|..||..||. ||. |..|||. || |.|.|| | . aeekkwlselestkWlehiklllkaavkivekvekektsvlvhcsdGWdrtaqltslaqllldpyyrtieGfevliekeWlsfGhkfaerlghgdksese GTESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDS .||.|| |.|||.||..|||.||||...||| . | eersPvflqfidcvyqltkqfptafefnesflikildh |
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| Phosphatase | Spur_hmm30030,hmm264741,hmm83000,hmm332945.AA | Subfamily.MTMR1.PD | 110-246 | 40 | 6e-39 | 121.5 | In-house | 10-148 (149) | Show / Hide |
Range on Protein: 110-246 Range on HMM: 10-148/149 Sequence Identity: 40% (56 aa) TTDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDRCGHCVP--SS . ..||.|.|..||||. | . |. | ..||.. ....|... |.| | .. ..||. ..|||.||. ||. |..|||. || | .||| . . ideskwlsaleetkwlehiklilagavriadkvesektsvvvhcsdgwdrtaqltslamllldsyyrtikgfevliekewlsfghkfaerighgdknhad GTESPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDSM ||.|| |.||| |. .|||.||||...|||.. | . adrspvflqfidcvwqvtrqfptafefneeflitildhl |
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| Phosphatase | Spur_hmm30030,hmm264741,hmm83000,hmm332945.AA | Subfamily.C2-MTMR1.PD | 111-245 | 39 | 1.3e-36 | 114.0 | In-house | 2-135 (137) | Show / Hide |
Range on Protein: 111-245 Range on HMM: 2-135/137 Sequence Identity: 39% (53 aa) TDEKWYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDRCGHCVpSSGTE .| .|.| |.||.|| | . |. |. | . . ... |.| | . ...|.|..|| .||. |.. |..|||. || | .| |. |. sdvqwlsqlestqwlayikavlkaaraiarkveklavsalvhcsdgwdrtsqlvllaqllldpyyrtidglivliekewlafghkfderlggad-svser SPIFLLFLDCVHQLIEQFPSAFEFTDTFLIALWDS ||||| ||||..|. |||||||.| .|. | | spiflqfldclyqvtkqfpsafeytarlllklady |
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| Phosphatase | Spur_hmm30030,hmm264741,hmm83000,hmm332945.AA | Subfamily.MTMR3.PD | 115-243 | 40 | 5.9e-36 | 111.7 | In-house | 1-131 (135) | Show / Hide |
Range on Protein: 115-243 Range on HMM: 1-131/135 Sequence Identity: 40% (51 aa) WYSTLDSTKWLQTIGTCLSLAKEAADRIYIAEKTVIIKESQGRDYSCVVASLSQIMLDSHYRSQLGFQSLLQKEWIVAGHPFLDRCGHCVPS--SGTESP ..|.|..||||| . . | | . .. . .. |... |.| | . . .|....|| .||. ||. |...||. || | |||||| . ..|.|| flsalektkwlqhlsvllkaavkvvnavdkegrpvlvhcsdgwdrtpqivalakllldpyyrtlegfkvlverewldfghkfadrcghgedsddlnercp IFLLFLDCVHQLIEQFPSAFEFTDTFLIALW .||||||| .|||..|||...||. | vflqwldcvhqlkkqfptsfefneaflvklv |
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| 3-PAP | Spur_hmm30030,hmm264741,hmm83000,hmm332945.AA | 3-PAP | 385-447 | 28 | 4.1e-11 | 41.99 | Pfam | 84-152 (152) | Show / Hide |
Range on Protein: 385-447 Range on HMM: 84-152/152 Sequence Identity: 28% (20 aa) PLLQTPTITLWNHCYLRWVPSVHTVGGGSPAIYQQQCRLVDE--I---QQLRETLENLKVSK-ESVAAP |.. . | .| ||.||.| .....||.|.|......|.|| | | |.. |. . |. . .. PQCCGCHIKVWKQCYFRWIPWAQIRNGGQPQIFLHNMELMDEWYIHFHQKLQRCLHQRDMSDLPECYLE |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| Spur_hmm30030,hmm264741,hmm83000,hmm332945.AA | Protein | None | 529 | None | Fasta, JSON |
| Spur_hmm30030,hmm264741,hmm83000,hmm332945.NA | RNA | None | 1587 | None | Fasta, JSON |