Gene spur_hmm146889,hmm241049
spur_hmm146889,hmm241049
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_hmm146889,hmm241049.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Phosphatase | spur_hmm146889,hmm241049.AA | Subfamily.TIM50.PD | 151-301 | 71 | 8.8e-81 | 258.0 | In-house | 1-150 (150) | Show / Hide |
Range on Protein: 151-301 Range on HMM: 1-150/150 Sequence Identity: 71% (108 aa) PPYTLVLEMKDILVHPEWTYANGWRFKKRPGVEYFLQQAGpPLFEIVIYTSEQGFTAFPILDSLDPKGCIMYRLFRDATKYVNGHHVKDLSSLNRDLSKV ||||||||.||.||||||||..||||||||||..||.... .|||||..|||||.||.|..|.||||..|||||||||||||.|.||||||.|||||||| ppytlvlelkdvlvhpewtyktGwrfkkrPgvdafleela-elfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkdlsklnrdlskv IIVDCNAKSYQLQPKNALGLKKWEGNDDDRTLFELAAFLRTVAASGVEDVR |.||....|..|||.||| ||||.||.|||.|..|.|||.|.|.|.||||| ivvdldkesvklqpenalalkkwkGnaddrelldllaflktiatsevedvr |
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Phosphatase | spur_hmm146889,hmm241049.AA | CPDc | 151-280 | 32 | 7.7e-57 | 196.06 | SMART | 1-173 (173) | Show / Hide |
Range on Protein: 151-280 Range on HMM: 1-173/173 Sequence Identity: 32% (56 aa) PPYTLVLEMKDILVHP-----------------EWTYA----------------------NGWRFKKRPGVEYFLQQAGPPLFEIVIYTSEQGFTAFPIL ...||||.... |||. |||.. .|..||||.|..||.... ..|....|... .|.|.| KKKTLVLDLDHTLVHSCMIPTLHHWMKYLRSFKEWTRRDFIWPQLKWFHMCMIVEIDGHPHQWYVKKRPHVHEFLKRCS-KWYEMHVFTMGMRMYADPVL DSLDPKG-CIMYR-LFRDATKYVNGH-HVKD-LSSLNR-DLSKVIIVDCNAKSYQLQPKNALGLKKWEGNDDDR | ||||. ..|| |.||...|..|. .||| || .|| |||.|||.|.. .|. ..|.||. |.| .. .|. DMLDPKRKYFIYRRLYRDHCVYHKGKTYVKDTLSLVNRCDLSMVIIIDDSPDSWPWHPENAIPIKPWFYFMHDT |
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Phosphatase | spur_hmm146889,hmm241049.AA | NIF | 153-301 | 33 | 2.8e-55 | 194.75 | Pfam | 1-189 (189) | Show / Hide |
Range on Protein: 153-301 Range on HMM: 1-189/189 Sequence Identity: 33% (65 aa) YTLVLEMKDILVHPE--WTYA---------------NGWRFKK-RPGVEYFLQQAGPPLFEIVIYTSEQGFTAFPILDSLDP--KGCI--MYRL---FRD .|||| . . ||| . |.. .|...| ||....|||.. ..||||.|. . .| |..| .|| |... .|| .|. KTLVLDLDETLVHCNPWWEPPNWHDFIVPIPFNGQNHQWYVYKPRPYCDEFLQHM-SKYYEIVIWTASMKEYADPVIDYIDPKSKKYFDGHHRLICWYRE ATK-YVNG-HH-V-KDLSSL--NR-DLSKVIIVDCNAKSYQLQPKNALGLKK-WEG-----N-DDD--RTLFELAAFL-RTVAASGV-EDVR ... |.|| .. | |||| | || |||.||||| .. |. ||| |.. . | | . .|| . |..| || . .| ... .||| HCWLYRNGGNYYVKKDLSILWYNRWDLSRVIIVDNSPHSW-LQPDNGIPIPPYWYGYHDDDDSPDDFWNELLDLLPFLIEYLA-LQCLDDVR |
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Phosphatase | spur_hmm146889,hmm241049.AA | Family.FCP.PD | 152-301 | 38 | 8e-47 | 148.0 | In-house | 2-164 (164) | Show / Hide |
Range on Protein: 152-301 Range on HMM: 2-164/164 Sequence Identity: 38% (64 aa) PYTLVLEMKDILVHPEWT---------------YANGWRFKKRPGVEYFLQQAGpPLFEIVIYTSEQGFTAFPILDSLDP-KGCIMYRLFRDATKYVNGH ..|||.....||| |.. ... ...||||....||.... .|.||||.|... .| |..| ||| |.....||.||....|.|.. kklLVlDLdetLvhselkpknkpdfvvkveideleetvyvkkRPhldeFLekvs-elyeiviftastrkyadpvadiLDpekklfkkrllrdecvlvkgn HVKDLSSLNRDLSKVIIVDCNAKSYQLQPKNALGLKKWEGNDDDRTLFELAAFLRTVAaSGvEDVR |||||.|.||||||||.|.. .||.|.|.||. .|.......|..|..|..||...| . |||| yvkdLsklgrdlskviiiDdspdsyklnpdnaikvksfkedpkDteLldLlpflesla-ke-edvr |
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Phosphatase | spur_hmm146889,hmm241049.AA | Group.HAD.PD | 153-301 | 24 | 2.1e-33 | 104.8 | In-house | 2-190 (190) | Show / Hide |
Range on Protein: 153-301 Range on HMM: 2-190/190 Sequence Identity: 24% (46 aa) YTLVLEMKDILV-HPEWTYANGWRFKKR-------------------------------PGVEYFLQQAGPPlFEIVIYTSEQGFTAFPILDSLDP-KGC .|||| ... |. |.......|.|.|.. |....||...|. .|.|..|.... .| |... .|..... dtlvlDldgvlwlhgspepleglrskgkvlifltnnatksrlyllkrlallgflveevephldeflervgel-yelvvftagtreyadpvvgavdvgdea IMYRLFRDATKYVNGHHVK------DLSSLNRDLSKVIIVDCNAKSYQL--QPKNALGLKKWEGNDDDRTLFELAAFLRTVAASGVEDVR .||..|||. |..|.... ||. |.|||.||.|.|...... . .|.||| .... . .| .|. | .| ... . ..||. fsyrklrdacvylkgpgalllatnrdlgalvrdlekvviidnkpsvfafecnpenalmigdfiddildaellglipdlenidvrfgkdvg |
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Phosphatase | spur_hmm146889,hmm241049.AA | Subfamily.SCP.PD | 177-294 | 41 | 6.3e-31 | 96.0 | In-house | 42-158 (163) | Show / Hide |
Range on Protein: 177-294 Range on HMM: 42-158/163 Sequence Identity: 41% (48 aa) KKRPGVEYFLQQAGpPLFEIVIYTSEQGFTAFPILDSLDPKGCIMYRLFRDATKYVNGHHVKDLSSLNRDLSKVIIVDCNAKSYQLQPKNALGLKKWEGN .||| |. ||.. | |||.|..|. . | |..| ||.|. | .||||.. ...| .||||| | |||.||.||| .|| ..|.||... | . lkrpfvdeflkkvg-elfevvlftaslakyadpvadlldkknvikarlfrescvfhkgnyvkdlsrlGrdlkkvvivdnspasyifhpdnavpveswfdd DDDRTLFELAAFLRTVAA .|. | .| .| ... eedtelldllplleelsk |
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Phosphatase | spur_hmm146889,hmm241049.AA | Subfamily.HSPC129.PD | 177-301 | 37 | 4.9e-26 | 80.2 | In-house | 42-164 (164) | Show / Hide |
Range on Protein: 177-301 Range on HMM: 42-164/164 Sequence Identity: 37% (47 aa) KKRPGVEYFLQQAGpPLFEIVIYTSEQGFTAFPILDSLDPK-GCIMYRLFRDATKYVNGHHVKDLSSLNRDLSKVIIVDCNAKSYQLQPKNALGLKKWEG . || ...||.. |||....|. . | .|| |||. . .||||. |.| ..|||| | ||||| |||| ..... .|.| . .. | . rlrpflreflervs-klfevilftaskkvyadklldlldpekklvrhrlfrehcvcvdgnyikdlsilGrdlsktiivdnspqafayqlenGipieswfa NDDDRTLFELAAFLRTVAASgvEDVR ..|. |..| .||...| |||| dendsellkllpfleklaek--edvr |
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Phosphatase | spur_hmm146889,hmm241049.AA | Subfamily.DULLARD.PD | 175-293 | 33 | 3.5e-24 | 74.1 | In-house | 48-166 (172) | Show / Hide |
Range on Protein: 175-293 Range on HMM: 48-166/172 Sequence Identity: 33% (39 aa) RFKKRPGVEYFLQQAGpPLFEIVIYTSEQGFTAFPILDSLDP-KGCIMYRLFRDATKYVNGHHVKDLSSLNRDLSKVIIVDCNAKSYQLQPKNALGLKKW . ||| |..||.. ...||.|. | ...| || .| . |..|. .|...|||| .. |||.|||.| ...|..|.||. .| | yvykrPhvdlfldvvs-kWydlviftasmeeyaaavvdkldsgrgilkrryyrqhCtlesgkytkdlslvsedlssviilDnspvayrknpdnaipiksw EGNDDDRTLFELAAFLRTVA . .| .|..| || .. isdpsdtallnllPfldalr |
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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spur_hmm146889,hmm241049.AA | Protein | None | 358 | None | Fasta, JSON |
spur_hmm146889,hmm241049.NA | RNA | None | 822 | None | Fasta, JSON |
spur_hmm146889,hmm241049.AA.PD_151-301 | Protein Phosphatase Domain | None | 151 | None | Fasta, JSON |