Gene spur_hmm160665,hmm109256
spur_hmm160665,hmm109256
Species: S.purpuratus
Alias: spur_hmm160665,hmm109256
External Links:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of spur_hmm160665,hmm109256.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.TAB1.PD | 52-390 | 53 | 3.1e-150 | 489.8 | In-house | 1-336 (336) | Show / Hide |
Range on Protein: 52-390 Range on HMM: 1-336/336 Sequence Identity: 53% (183 aa) HSGIGYSNNQVYRQDGARSEDHEYEDKFFHfRTEQDDYLYAIFDGYDGTYAPGFAHQGLPAELLLGQLsSVHDDAEVKRILLRAFVTVERGLFESLDHVV .||||.|||..|...|..|||||.|||.|. |||.|..|||.||||||..|..|..| | ||||||.| |....||.|..||... .||| .|||.|..| dsgiGisnneryskegsssedhenedkvfs-rteddiilyavfdGydGekaaefveqrLvaelllgdl-seeaeaepkllllqvieeverkffesiddav AERANLKLSLPDDVSDYELFQKYPEQMEKFHSMTADISGGTSAIVALIHVNKLFVANVGDSRALLCTLEPDNtTKVRQLSVDHTTNNQDELLRLSQLGLD ||||.|| .||..|..|||..||.|...........|||||.|.||||..|||.|||||||||.|.. |.|. .||.||||||...|.||| ||..|||| aeradlkstlpkgvasyeleekyeekinrlkeleseisgGttavvalilnnkLyvaNvGdsrAilvesekdg-ikvkQLsvdHnvdNedElkRlkdLGld TNTVQSNKLLGDKMATRTIGNHTVKGGYKENTLLCKASSEPILAEPDIIGGLDVTNMTGFLMMYSNGLSQSLIEATGTSQANLDLAYMAMAEFEVQATLS ......||.||.|.|||.||....|.||||...|..|..|||.|.||| |..|.....|||...|.||...|||.|....|...||.....|.|..|||. ieqikqnkrlgskeaTRsiGdykikkgykevdvlssAkgePiiatPdingpkdindlegfllLmSdGlykalieltnpptadvslallviqeaeksatld GVAQAVVDKVVRRHHDTYLSEGGRMAICQKRDDITLIVR |||||||.| |.|.|.|||.. |..||.||||.||||. dvaqavvdrvkrkhrdvylssakrsticrkrddmTlivl |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Group.PPM.PD | 59-393 | 23 | 8.7e-44 | 139.8 | In-house | 36-322 (459) | Show / Hide |
Range on Protein: 59-393 Range on HMM: 36-322/459 Sequence Identity: 23% (83 aa) NNQVYRQDGARSEDHEYEDKF-FHFRTEQDDYLYAIFDGYDGTYAPGFAHQGLPAeLLLGQLSSVHDD----------------AEVKRILLRAFVTVER |. | . ... .| ||.. .. . ...| ....|||. |. | ||.. || |. ||....|. ..||. | ||... | nglrygvasmqgwrkemEDrhvivenfdnndsffgVfDGHgGaeaaefaakkLpk-ilkkqlkkkkdevskksaeasldnddrgekvkkalrsaflelde GLFESLDHVVaeranlklslpddvsdyelfqkypeqmekfhsmTADISGGTSAIVALIHVNKLFVANVGDSRALLCtlepdNTTKVRQLSVDHTTNNQDE |. . ......||.|.|||| .||.|||.|||||.|| |...|| ||...|..| dlseeaneke---------------------------------epgkdsGtTAvvalingkklyvANaGDSravLc-----rngkavplskdHkpenpeE LLRLSQLG-LdtntVQS-NKLLGDKMATRTIGNHTVKGgykentllckaS--SepILAEPDIIgGLDVTNMTGFLMMYSNGLSQSLIeatgtSQANLDLA |. ..| |. ....| . .| .|.| .| . . ||||. ...|. ||.. |.|| .|.. .... ... reRIekagGs----veidgRvnGilavsRalGdhdlkk-----------eeqm--vsaePdvs-vvklteedeflvlAsDGlWdvls-----neevvefv YMAMAE--FEVQATLSGVAQAVVDKVVRRhhdtylseGGRmAICQKRDDITLIVRNFN .| . .|. .|...||. ... | . ....|.|| || .| retlekkkkelkkdleeiaerlvdealak--------gst-gdgtscDNiTvivvtln |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Family.PPM.PD | 66-392 | 22 | 1.4e-41 | 132.5 | In-house | 20-286 (495) | Show / Hide |
Range on Protein: 66-392
Range on HMM: 20-286/495
Sequence Identity: 22% (79 aa)
DGARSEDHEYEDKF--FHFRTE-QDDYLYAIFDGYDGTYAPGFAHQGLPAeLLLGQLSSVHDD----------AEVKRILLRAFVTVERGLFESLDHVVa
. ... .| ||.. .. . .| .|...|||..|. | ||.. |. |. ||....|. ..||..| .|| ... | |.|..
asmqgwrsemeDahvvvenlennedfslfgvfDGhgGaeaaefaakklhk-ilkkqlekkddeksstsaessaekvkealrkafleldeelseelneks-
eranlklslpddvsdyelfqkypeqmekfhsmtADISGGTSAIVALIHVNKLFVANVGDSRALLCtlepdNTTKVRQLSVDHTTNNQDELLRLSQLG--L
|. ..||.|.|.||. .||.|||.|||||.|| . |...|| ||...|..| |....| ..
---------------------------------agkdsGtTAvvvlirgkklyvAnaGDsravLc-----rngkavelskdHkpenpeEreRIekagGkv
DTntvQSNKLLGDKMATRTIGNHTVKGgykentllckA--SsePILAEPDIIgGLDVT-NMTGFLMMYSNGLSQSLIeatgtsqaNLDLAYMAMAEF-EV
..... | .| .|.. .| . ||||| ...| . . ||.. |.|| . | | ... ...... | .
vi---rdgrvnGvlavsRalGdfdlkk----------eeqa--ivsaePdit-svkltqeedeflvlasdGlWdvls--------neevvelvretleek
QATLSGVAQAVVDKVVRRHHDtylseggrmaicqkrDDITLIVRNF
..|. .|...||..... . |.|| .| .
eedleeiaeeLvdealakgsr---------------DNiTvlvval
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| Phosphatase | spur_hmm160665,hmm109256.AA | PP2Cc | 52-390 | 17 | 2.4e-29 | 104.75 | SMART | 1-338 (338) | Show / Hide |
Range on Protein: 52-390
Range on HMM: 1-338/338
Sequence Identity: 17% (74 aa)
HSGIGYSNNQVYRQ--DGARSEDHEYEDKFFHFRTEQDDYLYAIFDGYDGTYAPGFAHQGLPAELLLGQLSSVHDD------------------------
|| || .. .| . |. || .. . ....||| |. . .... |. | |. .|... ||
HS-MGYNSGWRYGYMESSMQGWRHPMEDAHVCRP------FFGVFDGHGGHECAQYCRKHLH-EHLAEELQFHKDDDYKENDEMQDEPEMWWRMWHDKWF
AEVKRILLRAFVTVERGLFESLDHVVAERANLKLSLPDDVSDYELFQKYPEQMEKFHSMTADISGGTSAIVALIHVNKLFVANVGDSRALLCTLEPDNTT
....| .|| .. . ..|.||||. |||.||||||||| ||. | .
EDWEDALRKAFLRMDEEI------------------------------------------------CTAVVALIRGNKLYVANVGDSRAVLCRNGND-NW
K------VRQLSVDHTTNNQDELLRLSQLGL------DTNTVQSN----KLLGD---KMATRTIGNHTVK----------GGYKENTLLCKASSEPILAE
. ..||..||. .|.||. |..|.| . . | ...| . .| .| | | .| . .. . . .. ||
WGIRHYTAHQLTEDHKPDNEDERRRIEQAGGRVMPMHRQWVMNWNCDVWRVNGVPIPLAVSRAFGDHYYKWKEDEKIEWNRWYQMFDPRLPFKEPYVIAE
PDI---------IGGLDVTNMTGFLMMYSNGLSQSLIEATGTSQANLDL---------------------------AYMAMAEFEVQATLSGVAQAVVDK
||. .| || . . || . . . . . | ..|..|. ... .
PDVTHHELWQMTV----PTPDDDFLILCCDGLWDVMSNQEVVDIVRKCLRKWHHKPVKNQAQENAHMMRHRQKKHNDPMEAAKRLCDCAI----------
VVRRHHDTYLSEGGRMAICQKRDDITLIVR
.|..| ||
---------------------CDNMTVIVV
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PDP.PD | 163-277 | 30 | 2.1e-20 | 63.5 | In-house | 140-255 (409) | Show / Hide |
Range on Protein: 163-277 Range on HMM: 140-255/409 Sequence Identity: 30% (34 aa) DDVSdYELFQKYPEQMEKFHSMTADISGgTSAIVALIHVNKLFVANVGDSRALLCTLEPDNTTKVRQLSVDHTTNNQDELLRLSQLGLDTNT---VQSNK .|.| | ..| .|.. . . ... .|| . |..|||. ..|.|||.||.||.|.. |.. . ....|| |.|..|..|. |. . . ......||| kdis-lealkkleekvleeavlkvalsG-acallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngR LLGDKMATRTIGNHTVKG . .| |. | lLgeLaPlRAFGdvryKw |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PPM1G2.PD | 55-320 | 26 | 5.6e-20 | 61.6 | In-house | 12-222 (275) | Show / Hide |
Range on Protein: 55-320 Range on HMM: 12-222/275 Sequence Identity: 26% (60 aa) IGYSNNQVYRQDgaRSEDHEYEDKFFHFRTEQDDYLYAIFDGYDGTYAPGFAHQGlpaelllgqlssvhddaevkrillrafvtverglfesLDHVVAER .| | | || . . | |..... . ... |.|.|||. |. . .| .| ...|.. ..| . . . | . |.. | ... | | |. vgvssmqGyrln--meDahilenelleksddkslalfavfDGhGGakvakyagkk-------------------------------------likkiakk ANLKLSLPDDVSdYELFQKYPEQMEKFHSMTaDISGGTSAIVALIHVNKLFVANVGDSRALLCTlepdnTTKVRQLSVDHTTNNQDELLRLSQLGldtNT |.|.||. .||.|||.|||||.|.. ...|..||.||....| |. . | .|. |. | | .|... | . | |. . . ksfkegaleqil-kdafletDeellkdeklk-desaGstavvvlikeeklyvanaGDsravlss-----kgnvkalsfDhkPqeesekkriiaag---Gf VQSNKLLGDKMATRTIGNHTVKGGYKentllCKASSEPILAEPDIIGgLDVTNMTGFLMMYSNGLS |.||.. .... . ||.. .|. velnrvngnLalsralgDfefkknvk-----kkpeeqivtavPDvlv-kkldeddeflvLaCDGiW |
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| Phosphatase | spur_hmm160665,hmm109256.AA | PP2C | 184-299 | 32 | 1.2e-19 | 72.32 | Pfam | 107-220 (284) | Show / Hide |
Range on Protein: 184-299 Range on HMM: 107-220/284 Sequence Identity: 32% (39 aa) MT-ADISGGTSAIVALIHVNK--LFVANVGDSRALLCTLEPD-NTTKVRQLSVDHTTNNQDELLRLSQLGLDTNTVQSNKLLGD-KMATRTIGNHTVKGG |. .....|..|..|.| .| |.|||.|||||.||. . | | ||..||. .|.|| |..|.| .... ... | .| .| . | . MHWECWHSGCTAVCAYIRNQKNILYVANCGDSRAVLCRNGNAHNW--VHQLTYDHKPSNEDERRRIRQAGGWVMWWGFWRVNGVWLAVSRAFGDFHYKPN YKENTLLCKASSEPILAEPDI .. ....|. ||||| HTC-----FPKEQPVTAEPDI |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PPM1K.PD | 73-276 | 28 | 1.8e-16 | 50.1 | In-house | 22-188 (264) | Show / Hide |
Range on Protein: 73-276
Range on HMM: 22-188/264
Sequence Identity: 28% (50 aa)
HEYEDKFFHFRTEQDDYLYAIFDGYDGTYAPGFAHQGLpaELLLGQLSsvHDDAEVKRILLRAFVTVERGLFESLDHVVAERanlklslpddvsdyelfq
.| ||.| ..| . .|.|||. |. | |.|. | | . .| . . .....| .|| ... | | . |||.. || |.... | . |
aenedrfklkeldpdllyfavfdGhgGssaadfvhdkl--eeivrrll--ekekdleevlkqafeeldkklkrylefsvaea------------------
kypeqmekfhsmTADISGGTSAIVALIHVNKLFVANVGDSRALLCTlepdnTTKVRQLSVDHTTNNQDELLRLSQLG--LDTNTVQSNKLLGDKMATRTI
.| .|..|||||.|| | ..|. ||. ....| |. . | ..|... .. . ||..|. ..|
------------ellssGttatvsllrdGnelvlaslGdsrailcr-----nGkakkltkdhdPerkeekerikaagGsvewnslgkplvnsrlamtrsl
GNHTVK
Gdldlk
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PPM1G.PD | 190-361 | 30 | 8.2e-16 | 48.2 | In-house | 307-460 (482) | Show / Hide |
Range on Protein: 190-361 Range on HMM: 307-460/482 Sequence Identity: 30% (52 aa) GGTSAIVALIHVNKLFVANVGDSRALLCTLepdntTKVRQLSVDHTTNNQDELLRLSQLGLDTNtvQSNKLLGDKMATRTIGNHTvkggYKENTLLCkAS || |.|||.. .||.|||.||||. |. | .||.|| ... || |. . | . . . | | .|.|. ||.|. | | sGttavvaLvkgkklivanaGDsRcvlsrn-----GkaldlsiDhkPeDeveleRiekaGGkvt--ldgRvnGGLnlsRalGDha----YktneeLp-ae SEPILAEPDIIgGLDVTNMTGFLMMYSNGLSQSLieatgTSQANLDLAYMAMAEFEVQATLSGVAQAVVDKV | | ||| | .|. ||.. ..|. .. .|| .| ..| | . .|| . ....|. eqmisalPDik-klilteedeFlvlacDGiWnvm-----ssqevvdFvraklkeseeskklseiceeLlDaC |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PPM1H.PD | 68-248 | 25 | 2.5e-14 | 42.9 | In-house | 46-215 (402) | Show / Hide |
Range on Protein: 68-248 Range on HMM: 46-215/402 Sequence Identity: 25% (45 aa) ARSEDHEYEDKffHFRTEQDDYLYAIFDGYDGTYAPGFAHQGLPaELLLGQLSSVHDDAEVKRILLRAFVTVERGLFESLDHVVAERANLKL-SLPDDvS . |..| ..| . ... . .....|||. |. | | . | . | .|..| . | .|. . .. .. ... |. ....| . . kageeeelkek--skeeklplayfglfDGhaGsgaalvaskllh-khlkekledvlellleksaeklalgeerkeaptepseifveekkiskeeLviG-a DYELFQKYPEQMEKFHSmTADISGGTSAIVALIHVNKLFVANVGDSRALLCtlepdNTTKVRQLSVDHTTNNQDEllRLSQL |.. ||... .. . |.|| .|.|||. .||.||| |||||.|. .. ....|| |.| . . . || .| lesaflemDeqiarere-ayrikGGCtalvalvllgklYvanaGDsRailv-----rkdeiiplsadftPeteRq--Rlqel |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.LRR-PP2C.PD | 172-273 | 30 | 7.5e-14 | 41.7 | In-house | 83-179 (257) | Show / Hide |
Range on Protein: 172-273 Range on HMM: 83-179/257 Sequence Identity: 30% (31 aa) QKYPEQMEKFHSMTadISGGTSAIVALIHVNKLFVANVGDSRALLCtlepDNTTKVRQLSVDHTTNNQDELLRLSQLGLD-TNTVQSNKLLGDKMATRTI . | | .. . . ||.|...|| .| ..|||||||..|| .. . ..||.|| ....| .|.|.|| .||.... | .|..| kaykeistqiserp--kfiGttaasvliiedkvyianvGdsrvvlc----qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsral GNH . Gds |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PPM1A.PD | 173-322 | 26 | 1.2e-13 | 40.9 | In-house | 95-231 (309) | Show / Hide |
Range on Protein: 173-322 Range on HMM: 95-231/309 Sequence Identity: 26% (39 aa) KYPEQMEKFHSMT--ADISgGTSAIVALIHVNKLFVANVGDSRALLCTLEpdnttKVRQLSVDHTTNNQDELLRLSQLGldtNTVQSNKLLGDKMATRTI . |...|. ... .| | |. |.|.|. .||..||.|||||.|. . || . || . ...| |... | .| ...| .|..| elDekirklvelskgedks-GsTavvvlvspkklylancGDsRavlsrng-----kvvfateDHkpsdpkEkeRienAg---GsvmikRvnGsLAvsRal GNHTvkggYKENTLLcKASSEPILAEPDIIGgLDVTNMTGFLMMYSNGLSQS .. |||.. . ||... . .||... .. .. ||.. . |. GDyd----ykekpek-kateqlvspepevtv-ierdeedeflvlacDGiwDv |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.ILKAP.PD | 189-277 | 32 | 1.7e-13 | 40.5 | In-house | 116-207 (298) | Show / Hide |
Range on Protein: 189-277 Range on HMM: 116-207/298 Sequence Identity: 32% (29 aa) SGGTSAIVALIHVNKLFVANVGDSRALLCTLEPDNTT------KVRQLSVDHTTNNQDELLRLSQLGldtNTVQSNKLLGDKMATRTIGNHTVKG |. |.|.|. |.|.|||.|||.|.|. ... .. .. .||.|||. ...| |. . | .|. ...|| | ||.|. kdGstavvvlvvdnvlyvanlGDskavlaRakeegdkagestiasvlLskdHtpasyeerkriqkaG---gvvrdgRvlGvlevsRsiGDgrfke |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PPM1L.PD | 74-276 | 27 | 1.9e-13 | 40.5 | In-house | 25-195 (273) | Show / Hide |
Range on Protein: 74-276
Range on HMM: 25-195/273
Sequence Identity: 27% (47 aa)
EYEDKFFHFRTE---QDDYLYAIFDGYDGTYAPGFAHQGLPAELlLGQLSSVhddaevkR-------IllrafvtverglfesldhvvaeranlkLSLPD
. ||.| . . ..|.|||. | .| ||.. |. .. . .| ... . | |.. . .|| .. . ||. ||.|..||.. ..| |
rmedrfeieediknktgesffavfdGhGGefaaefakdvlvkai-knkliel-------dadkentvp---------------------------infsk
DVSDyELFQKYPEQMEKFHSmTADISgGTSAIVALIHVNKLFVANVGDSRALLCtlepDNTTKVRQLSVDHTTNNQDELLRLSQLGLDTNTVQSNKLLGD
||||||| .|. |.. | || || .. | |.. | . .. | .|..|.. .|
lltd-eilsvdekllekakr-aedia-GttalialvqesdlivanvGdsrGvly----dkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGv
KMATRTIGNHTVK
latsralGdyplk
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PPM1D.PD | 173-251 | 33 | 1.7e-12 | 37.2 | In-house | 102-176 (311) | Show / Hide |
Range on Protein: 173-251 Range on HMM: 102-176/311 Sequence Identity: 33% (27 aa) KYPEQMEKFHSmTAdisgGTSAIVALIHVNKLFVANVGDSRALLCTLEP-DNTTKVRQLSVDHTTNNQDELLRLSQLGLD ..|..... | || || | | .| .||.||.||||...| . || ... . ..| .|| .. .| |. .|| . eWpktksglls-ta----GttasvviirreklyvahvGDsgivlgvkepkekklrakeltkdHkPespeEkerieelGGe |
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| Phosphatase | spur_hmm160665,hmm109256.AA | Subfamily.PPM1E.PD | 182-276 | 27 | 1.2e-10 | 31.1 | In-house | 101-190 (269) | Show / Hide |
Range on Protein: 182-276 Range on HMM: 101-190/269 Sequence Identity: 27% (26 aa) HSMTADISGGTSAIVALIHVNKLFVANVGDSRALLCtlepdNTTKVRQLSVDHTTNNQDELLRLSQLGLDTNTVQSNKLLGDKMATRTIGNHTVK ... . .|. |.|.||. ..|.|| .|||.|||. . ....|| | ...|| |. ..| . . | .|.||.. | kaereklksGstavvvliekdqlyvaWlGDsqallv-----rkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk |
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Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| spur_hmm160665,hmm109256.AA | Protein | None | 579 | None | Fasta, JSON |
| spur_hmm160665,hmm109256.NA | RNA | None | 1737 | None | Fasta, JSON |
| spur_hmm160665,hmm109256.AA.PD_52-390 | Protein Phosphatase Domain | None | 339 | None | Fasta, JSON |