Gene Spur_hmm172634,hmm249702
Spur_hmm172634,hmm249702
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein domain
Protein domains of Spur_hmm172634,hmm249702.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit phosphatase group/family/subfamily, which is helpful to understand the relationship between phosphatases. Transmembrane region is predicted by TMHMM 2.0. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking. View complete domain list.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Family.PPP.PD | 51-308 | 21 | 2.6e-21 | 66.1 | In-house | 21-250 (349) | Show / Hide |
Range on Protein: 51-308 Range on HMM: 21-250/349 Sequence Identity: 21% (58 aa) DQKVSVDQLARDDQVVVEDEigqgddVAGhdaKAEDKMINeEEYISELCRKYSADRPIPEEEAELFLKELTFPIPTKPHLTLSEDDvagkrIFVIGDVHG ..|..|..| ... |||. | . ..... .. ..||. .. . ....|. .|.| . . ..| |. | . | |.||.|| ekksevkklsdeesieveds------ytg---prlsfklt-pdlvkelveafkekkqleakevlelleeakellkkepnlleveap-----itvcGDihG CYDNLLTLLHVADIDKNP-NalLIFVGDIINKGPKSLEVLNFV------RSSNSYSVMGNHERAAVRKLrlikmnVGYEPKASKQW-----LHDLNGSDY ..|.||.|... ... . ..|.||....|..|.||. .. .|. . . |||| . |.| .|.. . ... ...| . . qfdDLlrlfdinglppaenk--ylFlGDyVDRGkfsvEvilllfalkllypsrffllRGnhEsrsvnkv------ygfyeevkskykkgeeiyelfqevF EYlqeLPYTISIPsLNAVIVHGGLLP-GKPLEEHTQDEMLLmrniivegnelkatkHI-SQGQLWGELWKGP .. || . | . ..||||| | . |.. . | | .. ..|.| ||. | nw---LPlaalid-ekilcvhGGlspeltsldqirkierpl---------------eppkegllcdllWsdp |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Group.PPP.PD | 51-308 | 21 | 2.6e-21 | 66.1 | In-house | 21-250 (349) | Show / Hide |
Range on Protein: 51-308 Range on HMM: 21-250/349 Sequence Identity: 21% (58 aa) DQKVSVDQLARDDQVVVEDEigqgddVAGhdaKAEDKMINeEEYISELCRKYSADRPIPEEEAELFLKELTFPIPTKPHLTLSEDDvagkrIFVIGDVHG ..|..|..| ... |||. | . ..... .. ..||. .. . ....|. .|.| . . ..| |. | . | |.||.|| ekksevkklsdeesieveds------ytg---prlsfklt-pdlvkelveafkekkqleakevlelleeakellkkepnlleveap-----itvcGDihG CYDNLLTLLHVADIDKNP-NalLIFVGDIINKGPKSLEVLNFV------RSSNSYSVMGNHERAAVRKLrlikmnVGYEPKASKQW-----LHDLNGSDY ..|.||.|... ... . ..|.||....|..|.||. .. .|. . . |||| . |.| .|.. . ... ...| . . qfdDLlrlfdinglppaenk--ylFlGDyVDRGkfsvEvilllfalkllypsrffllRGnhEsrsvnkv------ygfyeevkskykkgeeiyelfqevF EYlqeLPYTISIPsLNAVIVHGGLLP-GKPLEEHTQDEMLLmrniivegnelkatkHI-SQGQLWGELWKGP .. || . | . ..||||| | . |.. . | | .. ..|.| ||. | nw---LPlaalid-ekilcvhGGlspeltsldqirkierpl---------------eppkegllcdllWsdp |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP_Nematode_4.PD | 141-264 | 26 | 1.6e-11 | 33.9 | In-house | 29-149 (271) | Show / Hide |
Range on Protein: 141-264 Range on HMM: 29-149/271 Sequence Identity: 26% (34 aa) RIFVIGDVHGCYDNLLTLLHVadIDKNPNALLIFVGDIINKGPKSLEVLNF------VRSSNSYSVMGNHERAAVRKLRLIKMNVGYepKASKQWLHDln | |.||.|. ...| |. . . . |. |.|.|| ...||...||| . . . . |||| | | | ... . | .. | pikvvgdlhaqfqdlirlfdl--lgrvpeeklvflgdyvdrgpqgievlillfclkiryrdrivllrgnheiasvnkkygfyeecvt--kygeelwad-- gsDYEYLQELPYTISIpSLNAVIVHGGLLP . ...|| . | . . . .|||| | --fqrcfnrlpisali-akkvlcmhgglsp |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Metallophos | 140-319 | 15 | 1.9e-11 | 44.08 | Pfam | 1-124 (124) | Show / Hide |
Range on Protein: 140-319 Range on HMM: 1-124/124 Sequence Identity: 15% (29 aa) KRIFVIGDVHGCYDNLLTLLHVADIDKNPNALLIFVGDIINKGPKSLE------VLNFVRSSNSYSVMGNHERAAVRKLRLIKMNVGYEPKASKQWLHDL || ..||.||.||.| .. | . .. ..||.||... || |.| .... . . | |.|||. . . . . . . MRILHCGDIHGQYDDL--NRLFEII-E-KPDFVIFTGDYVDRGPWSDECIWLLFCYKMNYPGPVYWVRGNHDYMHGNDFYGFY-E--------------N NGSDYEYLQELPYTISIPSLNAVIVHGGLLPGKPLEEHTQDEMLLMRNIIVEGNELKATKHISQGQLWGELWKGPRHVYFGHHALE . .. . . . ...||.. .. |. | .|| . DW-MWWWWF-WMPLA-LDDWKILCMHGPP---------------------------------------FCK-NGVDYVIRGHTHVP |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP_Nematode_5.PD | 141-261 | 27 | 9.9e-11 | 31.0 | In-house | 29-146 (274) | Show / Hide |
Range on Protein: 141-261 Range on HMM: 29-146/274 Sequence Identity: 27% (34 aa) RIFVIGDVHGCYDNLLTLLHvaDIDKNPNALLIFVGDIINKGPKSLEVLNFVRSSNS------YSVMGNHEraavrkLRLIKMNVGYEPKASKQWLHDLN | ..||.|| .|.|| ... .. . |. .|.|| ...|.||||| .. | . . |||| .. |.. |.. . |. . | pitivGdihGqlddllrifn--avGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrgnhe------vkkinklygfkeelkkkrqesly GSDYEYLQELPYTISIpSLNAVIVHGG . ..||| .. | . .||| kkfndvfselplcarv-skrilcmhGG |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP5C.PD | 82-263 | 25 | 2.7e-10 | 29.5 | In-house | 45-222 (346) | Show / Hide |
Range on Protein: 82-263 Range on HMM: 45-222/346 Sequence Identity: 25% (46 aa) AKAEDKMINeEEYISELCRKYSADRPIPEEEAELFLKELTFPIPTKPHLTLSEDDvAGKRIFVIGDVHGCYDNLLTLLHVADIDKNPNAlLIFVGDIINK | |.. | .|...|| ... ... ... | |.| . . .| |. . . .|.| | ||.|| . .|| .... . . |..| ||....| pkleeekit-kefvkellelfkkqkklhkkyalkilleakellkklpslveitip-etkkitvCgdihgqfyDllnifelnGlpseenp-ylfngDfvdr GPKSLEVL------NFVRSSNSYSVMGNHERAAVRKLRLIKMNVGYepKASKQwLHDLNGSDYEYlqeLPYTISIPSlNAVIVHGGLL |.||. . . . |||| . || . .| . | ... . || ... || . | . . ..||||| GsfsveviltllgfkllypnhfflsrGnhesdnmnklyGfegevka--kytek-vadlftevfnw---lPlahvine-kvlvvhGGlf |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP1C.PD | 142-212 | 28 | 5e-10 | 29.2 | In-house | 30-104 (271) | Show / Hide |
Range on Protein: 142-212 Range on HMM: 30-104/271 Sequence Identity: 28% (22 aa) IFVIGDVHGCYDNLLTLLHVADIdkNPNALLIFVGDIINKGPKSLEVLNFVR------SSNSYSVMGNHERAAVRKL . ..||.|| | .|| |.. . |.. .|.|| ...| .||| . .. ..| . . |||| |.. .. lkivGdihGqyadllrlfekggf--ppesnylflGdyvdrGkqsletivlllaykikypenffllrGnhecasinri |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP_Nematode_6.PD | 142-264 | 29 | 8.3e-10 | 28.1 | In-house | 30-150 (272) | Show / Hide |
Range on Protein: 142-264 Range on HMM: 30-150/272 Sequence Identity: 29% (38 aa) IFVIGDVHGCYDNLLTLLHVADIDKNPNalLIFVGDIINKGPKSLEVLNF-----VRSS-NSYSVMGNHERAAVRKLRLIKMNVGYEPKAskqwlHDLNG | | ||.|| | .|| |.. . .. | .|.|| ...| .||||. . |. | . . |||| .|. . ..| |. . | . ikvcGdihGqysdllrlfdkggfppdan--ylflGdyvdrGrqslevillllaykvkfpnnffllrGnheceainrvyGfydevqrryks-----trlya SDYEYLQELPYTISIpSLNAVIVHGGLLP | .. ||.| . | . .|||| . afqevfnalpltalv-sgrilcmhGGlsk |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP3C.PD | 142-262 | 24 | 1.9e-08 | 23.7 | In-house | 30-147 (292) | Show / Hide |
Range on Protein: 142-262 Range on HMM: 30-147/292 Sequence Identity: 24% (30 aa) IFVIGDVHGCYDNLLTLLHVADIDKNPNalLIFVGDIINKGPKSLEVLNFVRS------SNSYSVMGNHERAAVRKLrlikmnVGYEPKASKQWLHDLNG | ||||.|| . .|| |..|. .... .|.|| ...| |.|.. .. . |. . . |||| . . . .. .... ... . itviGdihGqfydllklfevgGkpastk--ylflGdyvdrGyfsiecvlylyalkiaypsrlfllrGnhecrhltey------ftfkeevkikyseevye SDYEYLQELPYTISIpSLNAVIVHGGL | .. || . . . . ||||| almesfdslplaall-nqkflcvhGGl |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP7C.PD | 137-206 | 32 | 2.2e-08 | 23.1 | In-house | 65-139 (338) | Show / Hide |
Range on Protein: 137-206 Range on HMM: 65-139/338 Sequence Identity: 32% (24 aa) VAGKRIFVIGDVHGCYDNLLTLLHVADIDKNPNAlLIFVGDIINKGPKSLEVLNF------VRSSNSYSVMGNHER . |.. | ||.|| |.|| .|. . . |. .| || ...| .|.|.| | . | |||| aiskevtvcgdlhgklddlllilyknGlpsaenp-yvfnGdfvdrGkesveillilfalllvypkevylnrGnhed |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP4C.PD | 142-211 | 28 | 3.4e-07 | 19.7 | In-house | 30-103 (271) | Show / Hide |
Range on Protein: 142-211 Range on HMM: 30-103/271 Sequence Identity: 28% (22 aa) IFVIGDVHGCYDNLLTLLHVADidKNPNALLIFVGDIINKGPKSLEVLNF-----VRSSNS-YSVMGNHERAAVRK . | ||.|| . .||.|..|. . |. .|.||....| |.| . . || . . . |||| . . vtvcgdihgqfydllelfkvgg--dvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitq |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP_Nematode_7.PD | 142-194 | 25 | 7.9e-07 | 18.3 | In-house | 30-91 (296) | Show / Hide |
Range on Protein: 142-194 Range on HMM: 30-91/296 Sequence Identity: 25% (16 aa) IFVIGDVHGCYDNLLTLLH---VADIDKN----P--NALLIFVGDIINKGPKSLEVLNFVRS . ..||.|| |..| .| . .|. . . ..|.|| ...| ||.| . | . vtivGdihGqyeDLvriLnarvskeeakqksalsfvrkkfvfLGdYvdrGsksieCisLvfa |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP2C.PD | 142-192 | 33 | 1e-06 | 18.2 | In-house | 30-78 (271) | Show / Hide |
Range on Protein: 142-192 Range on HMM: 30-78/271 Sequence Identity: 33% (17 aa) IFVIGDVHGCYDNLLTLLHVADidKNPNALLIFVGDIINKGPKSLEVLNFV . | ||||| . .|| |... | |.. .|.|| ...| |.|.. .. vtvcgdvhgqfhdllelfrigg--kspdtnylfmgdyvdrgyysvetvtll |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP6C.PD | 142-191 | 31 | 3.1e-06 | 16.5 | In-house | 30-77 (271) | Show / Hide |
Range on Protein: 142-191 Range on HMM: 30-77/271 Sequence Identity: 31% (15 aa) IFVIGDVHGCYDNLLTLLHVAdiDKNPNALLIFVGDIINKGPKSLEVLNF . | ||.|| . .|. |.. . . |.. .|.|| ...| ||| . vtvcgdihgqfydleelfrtg--gqvpdtsyvflgdfvdrgyysletftr |
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Phosphatase | Spur_hmm172634,hmm249702.AA | Subfamily.PPP_Nematode_2.PD | 140-194 | 24 | 4.3e-06 | 15.7 | In-house | 31-83 (281) | Show / Hide |
Range on Protein: 140-194 Range on HMM: 31-83/281 Sequence Identity: 24% (13 aa) KRIFVIGDVHGCYDNLLTLLHVADIdkNPNALLIFVGDIINKGPKSLEVLNFVRS . |..|.|| . .|| .. . . .. .|.|| ...| .|.||. .. . lpvtvvadlhgqsidllriflinea--pgiskylflgdyvdrgrqsvevvlllla |
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
Spur_hmm172634,hmm249702.AA | Protein | None | 376 | None | Fasta, JSON |
Spur_hmm172634,hmm249702.NA | RNA | None | 1128 | None | Fasta, JSON |
Spur_hmm172634,hmm249702.AA.PD_140-319 | Protein Phosphatase Domain | None | 180 | None | Fasta, JSON |