MUSCLE (3.8) multiple sequence alignment CDC25-a_MbreP137_AA ------------------------------------------------------------ ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ MIH1_ScerP053_AA ------------------------------------------------------------ CDC25-b_MbreP138_AA ------------------------------------------------------------ cdc25_DdisP112_AA MGPTENQSFEIEFPNSSNTAAANSISTAINNNTTTAATITFTPANNNINNINNNNNNNNN CDC25_AqueP217_AA ------------------------------------------------------------ twe_DmelP140_AA ------------------------------------------------------------ CDC25B_HsapP189_AA ------------------------------------------------------------ CDC25A_HsapP188_AA ------------------------------------------------------------ CDC25_NvecP153_AA ------------------------------------------------------------ stg_DmelP139_AA ------------------------------------------------------------ CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA ------------------------------------------------------------ CDC25-a_MbreP137_AA ------------------------------------------------------------ ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ MIH1_ScerP053_AA ------------------------------------------------------------ CDC25-b_MbreP138_AA --------------------------------MSNSSMPSRLRRNSHATRAILNDASNN- cdc25_DdisP112_AA NKFNSNFDIESNKENSINQSNINSNVNSFPLKIQTKTLNSTTTSSNNNNNNIFSIGFRPL CDC25_AqueP217_AA ------------------------------------------------------------ twe_DmelP140_AA ------------------------------------------------------------ CDC25B_HsapP189_AA -----------------------------MEVPQPEPAPGSALSPAGVCGGAQRPGHLP- CDC25A_HsapP188_AA ------------------------------MELGPE--------PPHRRRLLFACSPPP- CDC25_NvecP153_AA -------------------QPSHLNLESQLHSGFISTGNTRNKKQKSSKAEFNMAGFCRQ stg_DmelP139_AA ------------------------------------------------------------ CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA -------------------------------------------------MDELDIMERNK CDC25-a_MbreP137_AA --------------------MAFSAPDLTTDVAGASNT---------------------- ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ---------------------MNRPSQISQDVAQ-------------------------- K06A5.7_CeleP116_AA ---MATTGEKAIYEDQNNVNIIENVVDVANGINESPKTLFEEDGSS-------------- R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------MCVDVPCENCIVRNDGLRL----------------------- MIH1_ScerP053_AA ----MNNIFHGTEDECANEDVLSFQKISLKSPFGKK------------------------ CDC25-b_MbreP138_AA ---SLKENSPSSSNSCGERDCSSPSMPREHRQNGRKLISKKSSR---------------- cdc25_DdisP112_AA SPRGVSPRFHSNSSSSCSSEISTPSSSTFLEDPNLIASNTISSNNSINNNNNNNNNNNNN CDC25_AqueP217_AA ------------MSQRLVASMFSPVTFDISPEEGNT------------------------ twe_DmelP140_AA ----------------------MASKRLMLDVEE-------------------------- CDC25B_HsapP189_AA ---GLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTH CDC25A_HsapP188_AA ---ASQPVVKALFGASAAGGL-SPVTNLTVTMDQLQGLGSDYEQPLE------------- CDC25_NvecP153_AA RADSFTLDFQNSSGDVAPNAVLSPITELSMNFEHNSISMGKTPKRKL------------- stg_DmelP139_AA ----MLWETIVEENNCSMDCNISNNTSSSSSINKMSGS---------------------- CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA KKLTLPLSNDCVFSPCFSQTQASPVTALSMSMVTLSCMGGTPKRRLS------------- CDC25-a_MbreP137_AA AEEDAANNICLTRLNQSPVSDSGIATSS--------PSSPLFDHNLSL---------HDN ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA PLSNQHETAMMSSDEDSMSRDSGICELM-------DENTPVCFSSMST------------ K06A5.7_CeleP116_AA RDSGVSMTSCSDKSDASPEEDVDFSKLESGRVALTDCSNFVSILQRNS--------SVSS R05H5.2_CeleP166_AA -----------------MLKNVNNCLSK-------------------------------- ZK637.11_CeleP239_AA --------------------KCSECAEG----------SSKLFPRQNR------------ MIH1_ScerP053_AA KNIFRNVQTFFKSKSKHSNVDDDLINKE----NLAFDKSPLLTNHRSK------------ CDC25-b_MbreP138_AA SSRNSASEPYSSGSPRTTTWVHSRCSAASSCSELSPCSSPVLFASHNE----------QL cdc25_DdisP112_AA NNNNNNDNSNNNINTNNINNNNNNTNNGENPQKKQRNSQILSKNFYSL--SLHADSPKHS CDC25_AqueP217_AA VKRTPRRKLCLDDSIHSPTTTDSACSTSCSMNSDSECSTSIDRRHSLA------------ twe_DmelP140_AA -----------------EDDESGACGQENFDPH---DADMEYQAKRRK---------SAV CDC25B_HsapP189_AA LSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIR CDC25A_HsapP188_AA VKNNSNLQ----RMGSSESTDSGFCLDSPGPLD---SKENLENPMRRI------------ CDC25_NvecP153_AA SLSNCDNASPSPCFLRTMSNESGYCPDSPMWPS---CESPTIELLRSTADMKKSFHLRRP stg_DmelP139_AA RRARRSLELMSMDQEELSFYDDDVVPQD-----QQRSASPELMGLLSP------------ CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA MSSIGEASPVPPNLSRHSSHSSGVSVGTPSP-----CESPLILGTFQP--INPSNDQPES CDC25-a_MbreP137_AA IRYTQSALATRPGPSDSPTLNFNDLNLSSPAKRGNGSAV--------------------- ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA --ESTTVQVEECMEIDEDENLQPGPVSRRQKKVTFRREKSSCQVR--------------- K06A5.7_CeleP116_AA SRSSSFYNYDTPTGRKMKTVFDLDSLDHSEYEKRVMSERPTDNHRKRT------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ----------QHSSAISHI----------------------------------------- MIH1_ScerP053_AA -------EIDGPSPNIKQL-----------------GHRDELDENENE------------ CDC25-b_MbreP138_AA RPASRTHILPNHTDEALSAE-------FGGVQLGSQSVIDVLEDDDDD-----GDAVFET cdc25_DdisP112_AA RSTTDLSTFLGMSDPDVMTYRSKTFCISDFHQFDIDTTTNDNKNKNNNTKSTDESSTFDG CDC25_AqueP217_AA ---TYPGKENVCSGPLSGAK-------LRPLSFSSLPLSPLSSNRNN------------- twe_DmelP140_AA QETPLQWMLKRHIPA------------STTVLSPITELSQNMNGARLD-------GTPKS CDC25B_HsapP189_AA RFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKEND-------GFVFK CDC25A_HsapP188_AA --HSLPQKLLGCSPALKRSH-------SDSLDHDIFQLIDPDENKENE-------AFEFK CDC25_NvecP153_AA SFRRWNSSPAGCDESDKENI-------NSPLVLQLDGCEGEGEADQKE-------EFVFA stg_DmelP139_AA ----------EGSPQRFQIV-------RQPKILPAMGV---------------------- CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA SRHSTQFRRFNSMPLRLQQQHQESPSLQMFHRPRLIRQHGLEEPMKEEEKEDGLWMMKPA CDC25-a_MbreP137_AA ------------------------------------------------------------ ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ MIH1_ScerP053_AA ------------------------------------------------------------ CDC25-b_MbreP138_AA CPWLKGNS---------------------------------------------------- cdc25_DdisP112_AA KSSNSVENNNMTIINNNNNNNNNNNNNNNNNNNNNNLNQDRPTIPTVAHSLSSNSIPHKF CDC25_AqueP217_AA ------------------------------------------------------------ twe_DmelP140_AA TQRIPANR---------------------------------------------------- CDC25B_HsapP189_AA MPWKPTHPSSTHALAEWASRREAFAQ---------------------------------- CDC25A_HsapP188_AA KPVRPVSRGCLHS-HGLQEGKDLFTQ---------------------------------- CDC25_NvecP153_AA RPRVPSFVRRFSK-GRLPPQRSLSDPL--------------------------------- stg_DmelP139_AA ------------------------------------------------------------ CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA GKRKDSEEENEEEKADSMQLDLPSPDIVEEATLPSEGFTFVMPKPLSARPASSRVSSLNF CDC25-a_MbreP137_AA -ESPQPPKMICRS-----------------------RSVGDLFSKRTFSERLSASCSRQA ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA --------------------------------------------MDSY------------ F16B4.8_CeleP059_AA -LFDESPTSHK---------------MFMRPQAPLSVRSENQQLLQQRKRKFEKSEQSSD K06A5.7_CeleP116_AA -SSSMSPSVTLLDR------------KRSRNLSLVAPQSDKSCRYNGLNNPRDDPFGDED R05H5.2_CeleP166_AA ------------------------------------------------NDNLQGIRLDSR ZK637.11_CeleP239_AA -SNSSPPTRKRSI-------------------------------DGGYTSGTDSAN---- MIH1_ScerP053_AA -NDDIVLSMHFASQ------------TLQSPTRNSSRRSLTNNRDNDLLSRIKYPGSPQR CDC25-b_MbreP138_AA -IEDHYEAMEFDND------------ILEELCVPTPDRSDGS--SRFPISKLSNLGASSL cdc25_DdisP112_AA NSSNSLPPQMLSSS---------APSLFSLLENSNNNNNNNNNNNNNNNNNNNNNNNNDN CDC25_AqueP217_AA -VLTSKPLMKHIS---------------SPLERMTLASPNSCSSDGYFSDVFDCVGEDPS twe_DmelP140_AA -TLNNFNSLSSRT--------------LGSFSSSCSSYESGNSLDDEYMDMFEMESAENH CDC25B_HsapP189_AA -RPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEE--DDGFVDILESDLKDDD CDC25A_HsapP188_AA -RQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTAT-LSDE--DDGFVDLLDGENLKNE CDC25_NvecP153_AA -SEQVSPARSDSVD-------------SGAGDMDIDD-VEAG--DDGFID--DLVNSQEE stg_DmelP139_AA -SSDHTPARSFRI-----------------FNSLSSTCSMESSMDDEYMELFEMESQSQQ CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA APAGSRPISAPATLLDEEEDDDAIQLQEDRLTSFHDDEDDDADNDDGFSDIFDTDSQEGS CDC25-a_MbreP137_AA SASNSPTRFHSTPCSSPLPTP--------------THPVS-------------------- ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA HFHLEPMSVEAMDDDEIVMMD--------------QNTTKWEPGF--------------- K06A5.7_CeleP116_AA DEVFEQSNVRNSQVQNTSIFA--------------------------------------- R05H5.2_CeleP166_AA LSVEQIPREDTAVKTPVVRYC--------------------------------------- ZK637.11_CeleP239_AA ------------------------------------------------------------ MIH1_ScerP053_AA SSSFSRS--RSLSRKPSMNSS--------------SNSSRRVQRQDGKIPRSSRK----- CDC25-b_MbreP138_AA NQSFPPANMTRQAAAT-------------------ASPQLTASRQIKPSNTAFRATCAQG cdc25_DdisP112_AA SNISINDESIVLISTPVKEYSYNRSLCLSDEEGGEDDEDDTPPTPIQLVRPTPTPINPSL CDC25_AqueP217_AA QEM-MPKCFSSLFAAPISSNC--------------DDDRESPVSRRGSMKRSLLETNDER twe_DmelP140_AA N-LELPDDLEVLLSGQLKSES--------------NLEEMSNKKGSLR------------ CDC25B_HsapP189_AA A---VPPGMESLISAPLVKTL--------------EKEEEKDLVMYSKCQRLFR------ CDC25A_HsapP188_AA EE--TPSCMASLWTAPLVMRT--------------TNLDNRCKLF--------------- CDC25_NvecP153_AA KDMNMPQGMANLLSAPLVSSN--------------CSPVTGTSSFTLLKEDTPKQINAEA stg_DmelP139_AA TALGFPSGLNSLISGQIKEQP-------------------AAKSPAGLSMRRPSVRRCLS CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA SSA-FSDGLAGLIHGALISPAGKAINSPPSHSIASESSQSGNIPNRGVDCNTLRTTPSGG CDC25-a_MbreP137_AA ------------------------------------------------CTYPIRNQRRPS ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------RAPNHKKGRLTR K06A5.7_CeleP116_AA ------------------------------------------------QPAPRTATSLWD R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------TSEIVIKKR--- MIH1_ScerP053_AA -----------SSQKFSNITQNTLNFTSA-------------------SSSPLAPNSVGV CDC25-b_MbreP138_AA QLAGSPLLLPAASQPSASPARQIAENPGRPAPR---------------RAVTLQRSQSES cdc25_DdisP112_AA SLSLSSSLNATNSTTYLHLGRSATVLLNPPLLVSSMRQHHNSPSSSPSQSIPIVQTRERS CDC25_AqueP217_AA -----------ESKKTPLPSPSSFTALQPP------------------SSPPAAHKSLKG twe_DmelP140_AA ------------------------------------------------RCLSMYPSEQPE CDC25B_HsapP189_AA -----------SPSMPCSVIRPILKRLERPQD----------------RDTPVQNKRRRS CDC25A_HsapP188_AA ----------DSPSLCSSSTRSVLKRPERSQE----------------ESPPGSTKRRKS CDC25_NvecP153_AA RPRDLFNTAGDKEKTRPRSKSFALKRPNPPR-----------------DPNPMEKKRLRQ stg_DmelP139_AA MTESNTNSTTTPPPKTPETARDCFKRPEPPASA---------------NCSPIQSKRHRC CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA PRCRKGIFKIPSQPVLARRNSSFLKRTERPQD----------------TPSPVQNKRPRS CDC25-a_MbreP137_AA ------GTLRRPSPTPASAQRTSSP----------------------------------- ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------SATAFPSLETFEEEEHEEQHH--------------------------------- K06A5.7_CeleP116_AA ------LAPPMFFERKTSDTSGNGSFQERPKQILRAMSVGEIDSE--------------- R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------LTFSKKSHSTSEIETWNAH----------------------------------- MIH1_ScerP053_AA ------KCFESCLAKTQIPYYYDDR----------------------------------- CDC25-b_MbreP138_AA ------AASRRPVPDLVPSSSEDRKSVPLSRDVRSEADVCSPLPK--------------- cdc25_DdisP112_AA QSSLSFLSPYQQQYYPSSPELSPMVPTPLVNRIFNNINNNNNNNNNNNNNNNNNNNNNNN CDC25_AqueP217_AA ------VALFRSQSVCVPPPCEDAMFPDSPGSGGVE------------------------ twe_DmelP140_AA ------EAVQEPDQETNMPMKKMQRKT-------LSMNDAEIMRA-------------LG CDC25B_HsapP189_AA ------VTPPEEQQEAEEPKARVLRSKSLC-----HDEIENLLDS--------------- CDC25A_HsapP188_AA ------MSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDN--------------- CDC25_NvecP153_AA ------RCMSLVESNSGLSPALLTRPGNLLKRSPFQRSNSEVFENRPNWQIGTFLGTE-- stg_DmelP139_AA ------AAVEKENCPAPSPLSQVTISHPPPLRKCMSLNDAEIMSA--------LARSENR CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA ------SSVASPQVTSMEAEKTSPKNRMCLGRSLSMLSPNDPYFRRIDQALSIEGGQHN- CDC25-a_MbreP137_AA ------------------------------------------------------------ ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ MIH1_ScerP053_AA ------------------------------------------------------------ CDC25-b_MbreP138_AA LQSA-------------------------------------------------------- cdc25_DdisP112_AA NNNNNNNNGTNSNNLNNQSTSEDRDDSPNTSLDQISGSPYKTPSKLSFHSPNSSAIFNSI CDC25_AqueP217_AA ------------------------------------------------------------ twe_DmelP140_AA DEPE-------------------------------------------------------- CDC25B_HsapP189_AA DHRE-------------------------------------------------------- CDC25A_HsapP188_AA DPRD-------------------------------------------------------- CDC25_NvecP153_AA SNRN-------------------------------------------------------- stg_DmelP139_AA NEPE-------------------------------------------------------- CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA ------------------------------------------------------------ CDC25-a_MbreP137_AA ----LHIVMDEQNV-LPTVRV--EHN-------QVTGDT--------------------- ARR2_ScerP075_AA ---------------------------------MVSFIT--------------------- YCH1_ScerP029_AA -----------------------SITNVK----YLDPTE--------------------- F16B4.8_CeleP059_AA ----LNVKYHLKTV---------AKESSKGFR-RITAET--------------------- K06A5.7_CeleP116_AA ----LPPTLEVKYT-LPGVDN--PQRESQAFR-SISPTT--------------------- R05H5.2_CeleP166_AA ---------------LPTVES--PQRESSSFR-SISATV--------------------- ZK637.11_CeleP239_AA ----LQVDYHLETV-TPSCST--VYQ-------KITSET--------------------- MIH1_ScerP053_AA ----NSNDF------FP----------------RISPET--------------------- CDC25-b_MbreP138_AA ----MQSDHDYEYP-LPLTDT--RHCKRKYIRAYISGET--------------------- cdc25_DdisP112_AA SNSQQTGKRSRTCLDFTKFSSHLLDEDSS----CFSTQTNNNNTSSTGLISPSSSPKQQN CDC25_AqueP217_AA ----RIGDHTKPYL-LPLTQG--TVPDQK----SISPDT--------------------- twe_DmelP140_AA ----LIGDLSKPCT-LPCLATGIRHRDLK----TISSDT--------------------- CDC25B_HsapP189_AA ----LIGDYSKAFL-LQTVDG--KHQDLK----YISPET--------------------- CDC25A_HsapP188_AA ----LIGDFSKGYL-FHTVAG--KHQDLK----YISPEI--------------------- CDC25_NvecP153_AA ----LIGDFSKTYV-LPSITG--QHEDLK----CISPET--------------------- stg_DmelP139_AA ----LIGDFSKAYA-LPLMEG--RHRDLK----SISSET--------------------- CDC25-b_SpurP195_AA ----------QACS-VPLVTG--KQKDLK----CISPET--------------------- CDC25-a_SpurP196_AA ----LTGDRTKACS-VPLVTG--KQKDLK----CISPET--------------------- . CDC25-a_MbreP137_AA ------------------------------------------------------------ ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ MIH1_ScerP053_AA ------------------------------------------------------------ CDC25-b_MbreP138_AA ------------------------------------------------------------ cdc25_DdisP112_AA VLIENTTNTTSNSSSSSSSTTTTTTTISVTNTLAAIQQNLNSNANLNNNNNNNNNNNNNI CDC25_AqueP217_AA ------------------------------------------------------------ twe_DmelP140_AA ------------------------------------------------------------ CDC25B_HsapP189_AA ------------------------------------------------------------ CDC25A_HsapP188_AA ------------------------------------------------------------ CDC25_NvecP153_AA ------------------------------------------------------------ stg_DmelP139_AA ------------------------------------------------------------ CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA ------------------------------------------------------------ CDC25-a_MbreP137_AA ------------------------------------------------------------ ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ MIH1_ScerP053_AA ------------------------------------------------------------ CDC25-b_MbreP138_AA ------------------------------------------------------------ cdc25_DdisP112_AA SSYFSRSNSISSQRPPRPLSMSSSFISRQSPDIHISSNSLPKPVDTSNTNNNNENENDTN CDC25_AqueP217_AA ------------------------------------------------------------ twe_DmelP140_AA ------------------------------------------------------------ CDC25B_HsapP189_AA ------------------------------------------------------------ CDC25A_HsapP188_AA ------------------------------------------------------------ CDC25_NvecP153_AA ------------------------------------------------------------ stg_DmelP139_AA ------------------------------------------------------------ CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA ------------------------------------------------------------ CDC25-a_MbreP137_AA -----------VIDTV----------------------------WGDGRRKFRD---Y-- ARR2_ScerP075_AA ------------SRQL----------------------------KGLIENQRKD---F-- YCH1_ScerP029_AA -----------LHRWM----------------------------QEGHTTTLREP--F-- F16B4.8_CeleP059_AA -----------LRDIF----------------------------FRLSEKEFDDK--Y-- K06A5.7_CeleP116_AA -----------LLLEF-----------------------------QRLGDDFDKK--Y-- R05H5.2_CeleP166_AA -----------FASLL-----------------------------RDRSRCLQL------ ZK637.11_CeleP239_AA -----------LIEIM------------------------------QKLSQIEFMQKY-- MIH1_ScerP053_AA -----------LKNIL----------------------------QNNMCESFYNS--C-- CDC25-b_MbreP138_AA -----------LSRLL----------------------------KGEYAEHFTH---V-- cdc25_DdisP112_AA KLDKINNVNSNIAKIIEQQQQRNISNSNNNNNLTQDQDQQDDQFKAKLLKQLSGRQGYNG CDC25_AqueP217_AA -----------VESLL----------------------------NGKHDTK------Y-- twe_DmelP140_AA -----------LARLI----------------------------QGEFDEQLGSQGGY-- CDC25B_HsapP189_AA -----------MVALL----------------------------TGKFSNIVDK---F-- CDC25A_HsapP188_AA -----------MASVL----------------------------NGKFANLIKE---F-- CDC25_NvecP153_AA -----------VTKLI----------------------------NGDYKDEIDE---Y-- stg_DmelP139_AA -----------VARLL----------------------------KGEFSDKVAS---Y-- CDC25-b_SpurP195_AA -----------MCRLL----------------------------RSEYDQEIAE---C-- CDC25-a_SpurP196_AA -----------MCRLL----------------------------RSEYDQEIAE---C-- . CDC25-a_MbreP137_AA --------------------IIIDARYPYEYDGGHLIGAVNF-Y---LPDMAAEYLLAR- ARR2_ScerP075_AA --------------------QVVDLRRE-DFARDHITNAWHV-P---VTAQITEKQLNQL YCH1_ScerP029_AA --------------------QVVDVRGS-DYMGGHIKDGWHYAY---SRLKQDPEYLREL F16B4.8_CeleP059_AA --------------------ILIDCRYPYEYNRGHIKNAINH-F---DRVTVSKIFYDEN K06A5.7_CeleP116_AA --------------------IIVDCRFPFEYKGGHVKGAINL-F---RHDKIKPIFFPEN R05H5.2_CeleP166_AA --------------------IIFDCRYPFEYFGGHIKGAVNI-Y---SLDELGKYLYDEY ZK637.11_CeleP239_AA --------------------ILIDCRYDYEYNGGHIKGAQSL-F---NPETAADFFFNKD MIH1_ScerP053_AA --------------------RIIDCRFEYEYTGGHIINSVNI-H---SRDELEYEFIHKV CDC25-b_MbreP138_AA --------------------LVLDCRFSFEYDGGHILNAQRA-W---LREHVLNHLFYNP cdc25_DdisP112_AA VSSESVYELLKNPTLINAIITVVDCRYKYEYDGGHIKNAINI-PPTGSRQMVLDRFFKFP CDC25_AqueP217_AA --------------------LIVDCRYPYEYEGGHIRGAINI-W---EKDTLLERFFSTP twe_DmelP140_AA --------------------EIIDCRYPYEFLGGHIRGAKNL-Y---TRGQIQEAFPTLT CDC25B_HsapP189_AA --------------------VIVDCRYPYEYEGGHIKTAVNL-P---LERDAESFLLKSP CDC25A_HsapP188_AA --------------------VIIDCRYPYEYEGGHIKGAVNL-H---MEEEVEDFLLKKP CDC25_NvecP153_AA --------------------YIIDCRYPFEFDGGHVKGAINI-Y---TKDEMLKQFIDTP stg_DmelP139_AA --------------------RIIDCRYPYEFEGGHIEGAKNL-Y---TTEQILDEFLTVQ CDC25-b_SpurP195_AA --------------------HVIDCRYPYEFNGGHIK----------------------- CDC25-a_SpurP196_AA --------------------HVIDCRYPYEFNGGHIKGAINI-Y---EEAELKKMFLENP :.* * :: .*: CDC25-a_MbreP137_AA -----------GDLSQTLILVHCEFSKERGPAL-YHYLKRVEAKACKNGGQGSLFPHLYV ARR2_ScerP075_AA IKGLSDTF---SSSQFVKVIFHCTGSKNRGPKVAAKFETYLQEEDITSKFESC------I YCH1_ScerP029_AA KHRLLEKQA--DGRGALNVIFHCMLSQQRGPSAAMLLLRSLDT-------AELSRCRLWV F16B4.8_CeleP059_AA G----------RKRCNKIPIFYCEFSQARGPKM-AYALRQVDRELNVNHYPKCDYEEMYV K06A5.7_CeleP116_AA GEA--------SSFQNRVPIFYCEYSQKRGPTM-AHAVRSIDRVLNELRYPHVEYPEMYL R05H5.2_CeleP166_AA GVK--------STLGGLIPIFYCEYSQVRGPAM-ARRLRKIDTHRNNHRAAALDFPEIYL ZK637.11_CeleP239_AA G----------SKKINRIPIFYCEYSQKRGPTM-ANNLREVDRKLNSNIYPRCDYEEIYL MIH1_ScerP053_AA LHSDTSN----NNTLPTLLIIHCEFSSHRGPSL-ASHLRNCDRIINQDHYPKLFYPDILI CDC25-b_MbreP138_AA QVPF-------TETHRTAVVFHCEFSAQRGPDQ-YEFARCLDDIFSHGTGQRL-WPNMFI cdc25_DdisP112_AA T----------PKNQQHVIIFHCEFSSKRAPDC-YSLFRELDREHN--EYPNIHYPEIYL CDC25_AqueP217_AA THPKSSS----ESEERNIIVFHCEFSSKRAPEM-SRFMRKVDRERNGMEFPKLYYPELYL twe_DmelP140_AA S----------NQENRRIYVFHCEFSSERGPKL-LRYLRSNDRSQHTHNYPALDYPELYI CDC25B_HsapP189_AA IAPC-------SLDKRVILIFHCEFSSERGPRM-CRFIRERDRAVN--DYPSLYYPEMYI CDC25A_HsapP188_AA IVP--------TDGKRVIVVFHCEFSSERGPRM-CRYVRERDRLGN--EYPKLHYPELYV CDC25_NvecP153_AA KC---------KEGKRVVVIFHCEFSSKRGPDM-CRFLRNRDRDIHRPSYPSLFYPELYL stg_DmelP139_AA QTELQQQQNAESGHKRNIIIFHCEFSSERGPKM-SRFLRNLDRERNTNAYPALHYPEIYL CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA LPPL-------PNNGRRVYVFHCEFSSQRGPKM-LRLLRAQDRSANLENYPALYYPELYL CDC25-a_MbreP137_AA LHQGYKQFH----A---EHP-TYCSPRGYVPMTTAAH----KSECQA------------- ARR2_ScerP075_AA LVGGFYAWE------------THCRESNLKLIVSG------------------------- YCH1_ScerP029_AA LRGGFSRWQ----S---VYGDDESVTAGYLP----------------------------- F16B4.8_CeleP059_AA LDLGYRNFFFAANE---ANITNLCQPHAYCEMHDKEH----TMELKKYN----------- K06A5.7_CeleP116_AA LDYGYKSLWST--A---ECR-QICEPCSYIPMTHSSF----SMEFKSARLERHHSMASLK R05H5.2_CeleP166_AA LDKGYVNFWS---D---VSLRDLCEPRYYISMHARPF----RHALQQYTQ---------- ZK637.11_CeleP239_AA LEGGYKNFYAFTRGLEKEQRVQLCEPDNYVIMFDDRY----KAELRKHQ----------- MIH1_ScerP053_AA LDGGYKAVF----D---NFP-ELCYPRQYVGMNSQENLLNCEQEMDK------------- CDC25-b_MbreP138_AA LEKGYREFY----K---NYP-EHCF-GKYCEMKDTTK----ASDLAHDEQILECSRLSVQ cdc25_DdisP112_AA LNGGYKKFF----E---SFQGDMCE-GNYIRMDDKLY----QANLKE------------- CDC25_AqueP217_AA IEGGYKNFY----A---THP-DLCEPKEYKTMLDTGH----KVDLMH------------- twe_DmelP140_AA LHNGYKEFF----G---LYS-QLCQPSQYVPMLAPAH----NDEFRY------------- CDC25B_HsapP189_AA LKGGYKEFF----P---QHP-NFCEPQDYRPMNHEAF----KDELKT------------- CDC25A_HsapP188_AA LKGGYKEFF----M---KCQ-SYCEPPSYRPMHHEDF----KEDLKK------------- CDC25_NvecP153_AA LDGGYKNFF----N---TCK-EHCEPQNYVLMLDENY----SNDLKL------------- stg_DmelP139_AA LHNGYKEFF----E---SHV-ELCEPHAYRTMLDPAY----NEAYRH------------- CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA LNEGYKAFF----E---YST-EFCEPKIYTPMNHDDH----LEDLRY------------- CDC25-a_MbreP137_AA ------------CEKKR-----QQVADS-------------------------------- ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ----------------------DLWR---------------------------------- F16B4.8_CeleP059_AA ------------FHNKG-----QSVLRTVSMSRSFKSLPTGSAFNFVASSASFTSAPST- K06A5.7_CeleP116_AA PNGETS------HREEKKKRCTRSVIRRNNSSLNMLSRSSSALTSTGSKTSSMENILYGL R05H5.2_CeleP166_AA ------------HRSKSTANDTKHKKTHMRIFSSEHLLDEPKMIDVPSGYERPTGAEET- ZK637.11_CeleP239_AA ------------FHKKNVSKPMKKWSSTTSVI---------------------------- MIH1_ScerP053_AA ------------FRRES-----KRFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSAL CDC25-b_MbreP138_AA DAEKLEEDHAAFFEMRK-----QFV----------------------------------- cdc25_DdisP112_AA ------------EEEKK-----KKEK---------------------------------- CDC25_AqueP217_AA ------------FSRRS-----KSW----------------------------------- twe_DmelP140_AA ------------FRAKT-----KSWQCGEGGDSGI------------------------- CDC25B_HsapP189_AA ------------FRLKT-----RSW----------------------------------- CDC25A_HsapP188_AA ------------FRTKS-----RTW----------------------------------- CDC25_NvecP153_AA ------------FSKRS-----KSW----------------------------------- stg_DmelP139_AA ------------FRAKS-----KSWNGDG------------------------------- CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA ------------FRAKS-----KSW----------------------------------- CDC25-a_MbreP137_AA -------------------------TIRRTRKRDSAISINEGEVCHFRF----------- ARR2_ScerP075_AA ------------------------------------------------------------ YCH1_ScerP029_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------STENIDTNDDCQKSRTPAVPRIASRRNLFSDPSHSPTNFAQFPLTCSR K06A5.7_CeleP116_AA DDERRPKWVSAFDIQSTESENDLDAALIYQRNISSNASNASSIVNLAEERIVQLGLQVIT R05H5.2_CeleP166_AA -------------------------STPRQPRARTPRARLLFEPCFTEID---------- ZK637.11_CeleP239_AA -------------------------SILTTSGTRISTLRQTCDPIHEHDAH--------- MIH1_ScerP053_AA SFRFEPPPKLSLNHRRVSSGSSLNSSESTGDENFFPILSKSSMSSNSNLSTSHMLLMDGL CDC25-b_MbreP138_AA -------------------------KGGRSALTNPRRMVQGGEPMTPVHQITKYR----- cdc25_DdisP112_AA -------------------------ITIRNIKAFKNRSHSFHV----------------- CDC25_AqueP217_AA -------------------------AGHSNVKGSRLRHRHSVPDIH-------------- twe_DmelP140_AA -------------------------GGGGSRGLRKSRSRLLYAE---------------- CDC25B_HsapP189_AA -------------------------AGERSRRELCSRLQDQ------------------- CDC25A_HsapP188_AA -------------------------AGEKSKREMYSRLKKL------------------- CDC25_NvecP153_AA -------------------------SEGQGKKSFRPGLNYR------------------- stg_DmelP139_AA -------------------------LGGATGRLKKSRSRLML------------------ CDC25-b_SpurP195_AA ------------------------------------------------------------ CDC25-a_SpurP196_AA ----------------------------TERSRLVTRSKSLF------------------ CDC25-a_MbreP137_AA -------------------------------------------------------- ARR2_ScerP075_AA -------------------------------------------------------- YCH1_ScerP029_AA -------------------------------------------------------- F16B4.8_CeleP059_AA ETPSPHKHPLTCPRFS---------------------------------------- K06A5.7_CeleP116_AA PDFPDRPSESSSTTPAGEHLPLGEGGHQIPCGILDFSSISDDAE------------ R05H5.2_CeleP166_AA -------------------------------------------------------- ZK637.11_CeleP239_AA -------------------------------------------------------- MIH1_ScerP053_AA DTPSYFSFEDERGNHQQVSGDEEQDGDFTFVGSDREDLPRPARRSLFPSLETEDKK CDC25-b_MbreP138_AA -------------------------------------------------------- cdc25_DdisP112_AA -------------------------------------------------------- CDC25_AqueP217_AA -------------------------------------------------------- twe_DmelP140_AA -------------------------------------------------------- CDC25B_HsapP189_AA -------------------------------------------------------- CDC25A_HsapP188_AA -------------------------------------------------------- CDC25_NvecP153_AA -------------------------------------------------------- stg_DmelP139_AA -------------------------------------------------------- CDC25-b_SpurP195_AA -------------------------------------------------------- CDC25-a_SpurP196_AA --------------------------------------------------------