MUSCLE (3.8) multiple sequence alignment DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQLSKTPSVTIKSYPDTDL----- INP53_ScerP068_AA_1-1080 MIIFVSEEPERRLAIVSNLYALVLKPVGKKPSDKPLCAIELLQKNDLKKYGFKR------ INP52_ScerP059_AA_1-1109 MKILLSKQQTRKIAIVSETHGLVFRPINSKNSRRSTCAVELVPKAELNGNGFRRL----- Dd5P3_DdisP050_AA_45-958 ------------------------------------------------------------ Synaptojanin_MbreP072_AA_56-790 ------------------------------------------------------------ Synaptojanin_AqueP153_AA_58-806 ------------------------------------------------------------ unc-26_CeleP194_AA_53-840 ------------------------------------------------------------ Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 ------------------------------------------------------------ Synaptojanin_NvecP085_AA_53-869 ------------------------------------------------------------ Synaptojanin_SpurP121_AA_48-803 ------------------------------------------------------------ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 ------------------------------------------------------------ SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 ----------TGPIVYVQNADGIFFKLAEGKGTNDAVIHLANQDQGVRVLGAEE------ DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 GKYTLYETKDRMYIVGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLE INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 -KVVLYETRARLYLVGSNNRETRFRLLTIDRLAHNRLSIEENANEFNSLEIRRFV----- CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 -KIVLYETKARFYIIGSNNAETEFRVLKIDRTEARELLLTDDKISYTLPQIKDLLQTLRH FIG4_HsapP107_AA_14-424 -KLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELL----- FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 --FVLYETKTRFYLVGSNRTKNRFKVLKIDRTYEEEVMISEDPTDYNKQQIQDLL----- INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 ------------SSDSNYLEVKSCIFNGLLGLVCL-------NGDIYVAVISGVQNVGFP INP53_ScerP068_AA_1-1080 -------------------LTSHEIF-GVIGLIEV-------NGLLFVGAITGKSKVA-- INP52_ScerP059_AA_1-1109 --------------------SNHEIY-GFIGLIEI-------EGLMFIATITGKSKVA-- Dd5P3_DdisP050_AA_45-958 --------------IDQSLRSERSVY-CVLGIFRL-------VNECYLVVVTESDIAA-- Synaptojanin_MbreP072_AA_56-790 ----------------------YDVY-GAIGVLELPTEKGSDVTAPVLLVVMDCKSNG-- Synaptojanin_AqueP153_AA_58-806 -----------------------TAY-ALLGVLQV------GQSLSYIVLVTGCNQVG-- unc-26_CeleP194_AA_53-840 ------------------YQKIVDAY-GILGVLAI------TKDEAVLVAVTGVLSVG-- Synj_DmelP055_AA_47-494 -----------TDVIRKQYTKVCDAY-GCLGALQL---NAGESTVLFLVLVTGCVSMG-- SYNJ2_HsapP111_AA_41-810 -----TLAPEEKEVIKGQYGKLTDAY-GCLGELRL---KSGGTSLSFLVLVTGCTSVG-- Synaptojanin_NvecP085_AA_53-869 -------------------QKILDAY-GCLGVLRI--NIDEEETIHFLILVTGCKSVG-- Synaptojanin_SpurP121_AA_48-803 ------------ESLRKQYQKMTDAY-GCLGALRL---SVGDESLLYLVLVTGCSSVG-- Synj_DmelP055_AA_664-825 ---------------------------AI-----------------------DCVKTG-- SYNJ1_HsapP110_AA_91-847 -----------------TYSKVLDAY-GLLGVLRL---NLGDTMLHYLVLVTGCMSVG-- SAC1_MbreP071_AA_26-522 IDRHSFEIRSGAAAKLDSAVDAGEFY-ALYGLLRL-------LSGPYLVLVCGVEAAA-- SAC1_ScerP042_AA_2-620 ---------------FPVQGEVVKIA-SLMGFIKL-------KLNRYAIIANTVEETG-- DDB_G0290653_DdisP053_AA_56-553 -------------------RSCVKIF-GCLGIINL-------LSGPFIICITDFETIG-- F30A10.6_CeleP073_AA_61-513 -----------------------FIY-GILGTIKL-------VSGYALIVITKASLIG-- Sac1_DmelP054_AA_58-502 ---------------------TRRIC-GVLGTIHL-------LSCDYLLVATHRLFVG-- SAC1_NvecP084_AA_52-521 -----------------PSADSVDIF-GIMGIIHL-------LAGPYLIVITKKKLVG-- SACM1L_HsapP109_AA_55-506 ----------------------RPIF-GILGTIHL-------VAGNYLIVITKKIKVG-- SAC1_SpurP120_AA_52-503 ---------------------SKPIC-GIMGIIKL-------LRGSYLVVITKKTKVG-- sac1_DdisP054_AA_36-493 -------SVGVPKNNEKVLTRIENVK-GIIGCIQL-------VSGHYLMIFKEHNHVA-- DDB_G0274537_DdisP052_AA_574-105 ------------------------AY-GIVGIINL-------LSGPYLIVITGKQLIG-- C34B7.2_CeleP032_AA_76-600 ----------KKGTKSGLIERATNAF-GILGCVRF-------VEGYYLIIITRAHAVA-- W09C5.7_CeleP200_AA_52-538 ----------------------------LIGKISF-------DEQHFLFFVVDSSVVA-- FIG4_ScerP064_AA_31-879 ------------EATEDGLHKKITGY-GLLGFIKF-------TCWYYLIMVTKYSQVA-- INPP5_AqueP152_AA_100-699 -----------------------HSF-GLIGKLQL-----LSNTGWYLLIITEAKSIG-- FIG4_MbreP070_AA_8-476 ------------------------SF----------------LKGYYLIVVTKRKQVA-- CG17840_DmelP052_AA_19-586 -------------ASLSGSPKVTSAY-GVLGFVRF-------LEGYYLLLVTKRKCCA-- CG7956_DmelP053_AA_49-573 -------------------------H-GIVGVISL-----PNVYEPHLVVVKEASAVG-- FIG4_SpurP118_AA_12-598 GNRGASPAPSSSSNPMAGWSRNVSAF-GIAGFVRF-------LEGYYIILITKRKKVA-- FIG4_HsapP107_AA_14-424 GRLDLGNRTKMGQKGSSGLFRAVSAF-GVVGFVRF-------LEGYYIVLITKRRKMA-- FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 --------TMIGNANREGLTRVCSAY-GILGFIRF-------LHGYYIILITKKRKVG-- INPP5F_HsapP108_AA_49-421 --------------------------EGVIGKIQL-----HSDLPWWLILIRQKALVG-- INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------VY-GVIGKIQF-----FPGGDWKLLVITKRTLLG-- INPP5_SpurP119_AA_47-407 -----------------------KVF-GVIGKLRI-----HPESEWRLLLIRSHRLVG-- INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 -----------------------------------------------NNNNNNNNNS--- INP51_ScerP033_AA_1-946 RWKLIDHQVRPSESIY-KVLDVDFY--------------------SLENDVFDYLLCERS INP53_ScerP068_AA_1-1080 --QPC-----PGETVN-KIFAVDFF--------------------CLNDNSWDFIEIDSS INP52_ScerP059_AA_1-1109 --QPI-----PNKTVN-KIYAVDFF--------------------CLNNSKWDFMDIDSS Dd5P3_DdisP050_AA_45-958 --NFQFQ---GQPNVIRKIRCTDFI--------------------SFQTGRGHISIGGGG Synaptojanin_MbreP072_AA_56-790 --RL------PGCQVY-HISRIDLV--------------------YLASAAHDERPH--- Synaptojanin_AqueP153_AA_58-806 --RI------SNTEVY-QITSTVMV--------------------PLHSNPSVHEGV--- unc-26_CeleP194_AA_53-840 --QL------YGADIL-KITNVEFI--------------------SLRTFGSVENVD--- Synj_DmelP055_AA_47-494 --KI------GDIEIF-RITQTTFV--------------------SLQNAAPNEDKI--- SYNJ2_HsapP111_AA_41-810 --RI------PDAEIY-KITATDFY--------------------PLQEEAKEEERL--- Synaptojanin_NvecP085_AA_53-869 --KV------LDSEIF-KITSTQFV--------------------PLQVD-QDEEGI--- Synaptojanin_SpurP121_AA_48-803 --KV------QESEIF-RITSTLFI--------------------SLRNNSSDEDRI--- Synj_DmelP055_AA_664-825 --L-------GGATGN-------------------------------------------- SYNJ1_HsapP110_AA_91-847 --KI------QESEVF-RVTSTEFI--------------------SLRIDSSDEDRI--- SAC1_MbreP071_AA_26-522 --RI------NGHVIY-SASDFELM--------------------PVASKTTGLVVE--- SAC1_ScerP042_AA_2-620 --RF------NGHVFY-RVLQHSIV--------------------STKFNSRIDSEE--- DDB_G0290653_DdisP053_AA_56-553 --SI------RETQILNRVAKHTIT--------------------PIARIPISLTEE--- F30A10.6_CeleP073_AA_61-513 --QV------NNHNIW-TIQDAEII--------------------PYKKTTLHLTEK--- Sac1_DmelP054_AA_58-502 --VL------NGAVVW-RLAGYDII--------------------PYIPNSFQRKEN--- SAC1_NvecP084_AA_52-521 --YI------QGSEVW-KVLQTNVI--------------------PFPRATLHLTES--- SACM1L_HsapP109_AA_55-506 --EF------FSHVVW-KATDFDVL--------------------SYKKTMLHLTDI--- SAC1_SpurP120_AA_52-503 --EI------NGQLIW-KVAGTETI--------------------PYKRTDLHLTEE--- sac1_DdisP054_AA_36-493 --TV------TGKKIY-QMKDVELI--------------------PFFPNQQSLVSI--- DDB_G0274537_DdisP052_AA_574-105 --SF------GGKYIY-RIENCNLI--------------------LISNNPTDLSEH--- C34B7.2_CeleP032_AA_76-600 --TL------GYHPVY-KIVEVAMI--------------------PIAMDGVSTSSE--- W09C5.7_CeleP200_AA_52-538 --CYRGTSAESSHSIR-RIERVIAI--------------------NVKSDGSVIKSQITP FIG4_ScerP064_AA_31-879 --VI------GGHGIY-HIDGIDII--------------------PITNNYKKPEKS--- INPP5_AqueP152_AA_100-699 --RLPN----TDSDVF-CIERVALI--------------------SLSAEKSIDEIKMET FIG4_MbreP070_AA_8-476 --SI------GAHAIY-RVEDTIMI--------------------SLFSKSVAGPDL--- CG17840_DmelP052_AA_19-586 --HI------GRHLVY-TIKDTVMV--------------------RVNEVTSQRPPH--- CG7956_DmelP053_AA_49-573 --VLY-----PPHLVY-KIKSICILSADDPDTDLPNCTKHTKSNQSTPTHSVSTSNNNNA FIG4_SpurP118_AA_12-598 --II------GGHTIY-KIEDTTMV--------------------HIPHDNFRKQHP--- FIG4_HsapP107_AA_14-424 --DI------GGHAIY-KVEDTNMI--------------------YIPNDSVRVTHP--- FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 --MI------GTHFIY-GIDDITYV--------------------YIPPSFPKTNSP--- INPP5F_HsapP108_AA_49-421 --KLP-----GDHEVC-KVTKIAVL--------------------SLSEMEPQDLELELC INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 --LFP-----GNHEVY-RVDRVAYL--------------------PLSPGDVPELELDPC INPP5_SpurP119_AA_47-407 --QLP-----KGHDVY-CITRIAVL--------------------PLSQNGHPDIEIERC INPP5_SpurP119_AA_256-568 ------------------SDDSDIK----------------------------------- DDB_G0279397_DdisP051_AA_271-666 ------------------------------------N------------------NNNDP INP51_ScerP033_AA_1-946 EQ-----------------------------------------------------NYDKL INP53_ScerP068_AA_1-1080 GYPVLPETAST--------------------------------------------EYQDA INP52_ScerP059_AA_1-1109 GYPIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSL-------------------NAQEQ Dd5P3_DdisP050_AA_45-958 GGGGSG-------------------------------------------------NGESK Synaptojanin_MbreP072_AA_56-790 ------------------------------------------------------------ Synaptojanin_AqueP153_AA_58-806 ------------------------------------------------------------ unc-26_CeleP194_AA_53-840 ------------------------------------------------------------ Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 ------------------------------------------------------------ Synaptojanin_NvecP085_AA_53-869 ------------------------------------------------------------ Synaptojanin_SpurP121_AA_48-803 ------------------------------------------------------------ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 ------------------------------------------------------------ SAC1_MbreP071_AA_26-522 ---------------------------------------------------------QQR SAC1_ScerP042_AA_2-620 ------------------------------------A------------------E---- DDB_G0290653_DdisP053_AA_56-553 ---------------------------------------------------------EKK F30A10.6_CeleP073_AA_61-513 ---------------------------------------------------------QIR Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ---------------------------------------------------------QQY SACM1L_HsapP109_AA_55-506 ---------------------------------------------------------QLQ SAC1_SpurP120_AA_52-503 ---------------------------------------------------------QKE sac1_DdisP054_AA_36-493 --------------------------------------------------------PDQD DDB_G0274537_DdisP052_AA_574-105 ---------------------------------------------------------DRK C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 GSGTKLKQGTEKIMKFFAEKV----------------------------------TKAEP FIG4_ScerP064_AA_31-879 -----------------------------------------------------------S INPP5_AqueP152_AA_100-699 YAQDRREKDVK--------------------------------------------DIGKL FIG4_MbreP070_AA_8-476 -----------------------------------------------------------P CG17840_DmelP052_AA_19-586 -----------------------------------------------------------P CG7956_DmelP053_AA_49-573 SVPSSGGGSSKSTKLFEGMNKTWGAVKSAGNTIKNTTQQAANLATKQVKSSVGIREPRHI FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ---------------------------------------------------------EFA INPP5F_HsapP108_AA_49-421 KKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESK---------EKEKL INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 EKHQSGGRGIKR----DTEGQQKSFQQTWKSIKTAATNIKENVKSTSTTKEPKDRERDKL INPP5_SpurP119_AA_47-407 DKHHFGIRQKANLILGPAEGQQKSLAKTWNSIKSVAQVKKKEVK-----------EREKL INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 TVKQMLKDLQTFPLDGTHFYC-------------ELYDLTNYFPSNLNTPH--------Q INP51_ScerP033_AA_1-946 IHEHPCGPLKKLFSDGTFYYS-------------RDFDISNIVKNH-------------G INP53_ScerP068_AA_1-1080 LPKHPCYELKKLLSNGSFYYS-------------SDFDLTSTLQHR-------------G INP52_ScerP059_AA_1-1109 APKHPCHELRKLLSNGSFYYS-------------TDFDLTCTLQKR-------------G Dd5P3_DdisP050_AA_45-958 EDDRPYVQVMNLLNSGHFYWT----------PPNSSFDITRTYQSQCL-----------E Synaptojanin_MbreP072_AA_56-790 --DYYCTYLKQLFATGSFYFSAREESLAPGANFTASARLTVHLPSAC------------Q Synaptojanin_AqueP153_AA_58-806 ------VAMGKLLASGQFYFS-------------VSVDERQNGGLF-------------S unc-26_CeleP194_AA_53-840 ---SRIIDLQRLLSSQMFYFS-----------SLQSYDLTRSAQHRDS------------ Synj_DmelP055_AA_47-494 ------SEVRKLLNSGTFYFAHTNASASASGASSYRFDITLCAQRRQQT----------- SYNJ2_HsapP111_AA_41-810 ------IALKKILSSGVFYFS--------WPNDGSRFDLTVRTQKQ-------------- Synaptojanin_NvecP085_AA_53-869 ------AEIVKLLNSGTFYFA-------------TGHGSQPELDLSLS------------ Synaptojanin_SpurP121_AA_48-803 ------TEVRKLLNSGTFYFS-------------WSASTTTRFDLSLC------------ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 ------SEVRKVLNSGNFYFA--------WSASGISLDLSLNAHRSMQ------------ SAC1_MbreP071_AA_26-522 AEERCLDLIRTVLKQRGLYFS-------------YTYDVTSPFSQQS------------K SAC1_ScerP042_AA_2-620 ----YIKLLELHLKNSTFYFS-------------YTYDLTNSLQRN-------------E DDB_G0290653_DdisP053_AA_56-553 EEKNYLTLLNDLIESCDLYFS-------------YNFDVTQSEQRASRIESN-------P F30A10.6_CeleP073_AA_61-513 YNRLFTDMLTHVLSIGGFYYS-------------TTLDISRTFQWLQENAV--------P Sac1_DmelP054_AA_58-502 --ENYLRLLRQTLDTKFFYFS-------------YRYDLTNSLQRQREVAQ--------S SAC1_NvecP084_AA_52-521 HNKLYLSMVQSVLQTESFYFS-------------CTYDLTHTLQRLSRTS---------P SACM1L_HsapP109_AA_55-506 DNKTFLAMLNHVLNVDGFYFS-------------TTYDLTHTLQRLSNTS---------P SAC1_SpurP120_AA_52-503 DNKVYESMVQYALENNTYYFS-------------TTFDLTHSLQRLYNTS---------P sac1_DdisP054_AA_36-493 AEEQHLSMIRWLLSSENFYFS-------------YDYDFTLTLQRQYSTTT--------T DDB_G0274537_DdisP052_AA_574-105 MESTYKKSLKNLLKS-NFYYC-------------FDYNISDNIENHFKN----------H C34B7.2_CeleP032_AA_76-600 -EQKYVKLFQSVDLSTDFYFS-------------YSYDMSRTFQENSLRS---------D W09C5.7_CeleP200_AA_52-538 RPALLDDVLKLFNDSKDFYFC-------------RSRDVTISSQ---------------K FIG4_ScerP064_AA_31-879 DEARLLNIFKDLDLTKTFYFS-------------YTYDITNTLQTN-------------I INPP5_AqueP152_AA_100-699 EKKLKEALLQMFNGSRSFYFS-------------YETDLTQSVQRKHDC----------G FIG4_MbreP070_AA_8-476 EEERYRRIFHNVDLTSNFYFS-------------HTYDLTRPVQSNMYLPSDLERQ---R CG17840_DmelP052_AA_19-586 HEDRYKRMFQNIDLRSNFYFS-------------YSYDLTRTLQYNESAPRYVGAKVDLD CG7956_DmelP053_AA_49-573 ERRITEELHKIFDETDSFYFS-------------FDCDITNNLQR--------------H FIG4_SpurP118_AA_12-598 DEARYLKMFQNVDLSSNFYFS-------------YSYDLTHSLQHNLSAYQNKG-----E FIG4_HsapP107_AA_14-424 DEARYLRIFQNVDLSSNFYFS-------------YSYDLSHSLQYNLTVLRMPLEMLKSE FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 DETRYKGLFLSLDLTKDFYFS-------------YTYDITRTLQYNMTRYFHSPIPKNIP INPP5F_HsapP108_AA_49-421 ERRLLEELLKMFMDSESFYYS-------------LTYDLTNSVQRQST-----------G INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ERRLVEELLKMFNDSDSFYYS-------------PTGDITNTLQRQCGD----------H INPP5_SpurP119_AA_47-407 ERRILEELNRMFTESDWFYYS-------------PTGDLTNSIQR--------------- INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 YCS--------------------------------------------EFTWNEWMRKPFE INP51_ScerP033_AA_1-946 LSHNLEYTVDNQDL---------------------------------SFIWNANLASEVI INP53_ScerP068_AA_1-1080 YGQHSLSTDTYEE----------------------------------EYMWNSFLMQEMI INP52_ScerP059_AA_1-1109 FTEHSLSFDDFDR----------------------------------EFMWNSFLMDEII Dd5P3_DdisP050_AA_45-958 PKSDLPVWERVDK----------------------------------RFYWNKYLQKDFI Synaptojanin_MbreP072_AA_56-790 RASRSPGERDS------------------------------------SYFWTRVPWTWVS Synaptojanin_AqueP153_AA_58-806 LLSRSQNRGGTTS----------------------------------QFCWNRSLYVYLQ unc-26_CeleP194_AA_53-840 -------HDCSDA----------------------------------RFFWNRSLHFSFQ Synj_DmelP055_AA_47-494 --------QETDN----------------------------------RFFWNRMMHIHLM SYNJ2_HsapP111_AA_41-810 -GDDSSEWGN-------------------------------------SFFWNQLLHVPLR Synaptojanin_NvecP085_AA_53-869 -AQQRYDGHSPDN----------------------------------RFMWNRSLHFHVQ Synaptojanin_SpurP121_AA_48-803 -AQRQKQDHVSDN----------------------------------RFFWNRSLHLHLQ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 -------EQTTDN----------------------------------RFFWNQSLHLHLK SAC1_MbreP071_AA_26-522 FTTNRDLYDIADR----------------------------------RFFCNRLLLEDLL SAC1_ScerP042_AA_2-620 KVGPAASWKTADE----------------------------------RFFWNHYLTEDLR DDB_G0290653_DdisP053_AA_56-553 LLMIQPLWKRCDR----------------------------------RFFWNYHLQQIFI F30A10.6_CeleP073_AA_61-513 LFKTRSMLDRASE----------------------------------RFIWNGHLLSQIR Sac1_DmelP054_AA_58-502 RPEVSGLLQRAEQ----------------------------------RFVWNGYVLRQFN SAC1_NvecP084_AA_52-521 EFLQMPLYERVDP----------------------------------RFVWNSHLLTPFA SACM1L_HsapP109_AA_55-506 EFQEMSLLERADQ----------------------------------RFVWNGHLLRELS SAC1_SpurP120_AA_52-503 EFLQMPLFERADQ----------------------------------RYVWNGHMLREFT sac1_DdisP054_AA_36-493 TTSGSSLGERCDS----------------------------------RFFWNEKYVTILS DDB_G0274537_DdisP052_AA_574-105 HNKQTNNNTNVNEENTTTTTTTTTTTTTTTLTESQETIYHLFEVFNSRFYWNKHLQTNLI C34B7.2_CeleP032_AA_76-600 WNNHGQRRLEADE----------------------------------RFVWNSFLLEPLR W09C5.7_CeleP200_AA_52-538 YFEKREAHTSED-----------------------------------SFFWNKRMVGNLG FIG4_ScerP064_AA_31-879 LREKLKAVDRCDITIPCGITDYNE-----------------------MFVWNNNLLSPIF INPP5_AqueP152_AA_100-699 DANKLRKWERVDE----------------------------------RFFWNKNMLQDLL FIG4_MbreP070_AA_8-476 LAEPKPPVLKPDE----------------------------------TFLWNHFLLHPFH CG17840_DmelP052_AA_19-586 RDEPLPDWNTLTSNVDKAHERVDYAFRSDSRK---------------RFVWNAYLLQPME CG7956_DmelP053_AA_49-573 EAKSEESQSQPDE----------------------------------RFFWNKHMIRDLI FIG4_SpurP118_AA_12-598 VGNPRVVPIHTKP----------------------------------KFAWNHYLWNRFQ FIG4_HsapP107_AA_14-424 MTQNRQESFDIFEDEGLITQGGSGVFGICSEPYM-------------KYVWNGELLDIIK FIG4_HsapP107_AA_229-641 -------------------------------------------------VWNGELLDIIK DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 QTNNNSNNNNNNNTNTNTNEINKKKLYYND-----------------QFTWNHFLLECLV INPP5F_HsapP108_AA_49-421 ERDGRPLWQKVDD----------------------------------RFFWNKYMIQDLT INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 YDHSLPLWKRVDK----------------------------------RFFWNSHMLHDLI INPP5_SpurP119_AA_47-407 --HHTHKGAGYDE----------------------------------RFFWNQHMLQDIL INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 NA----SLS------------HLCVVLLQGYASVKSISNLN------------------- INP51_ScerP033_AA_1-946 NW----RSKISNEEKQLFANAGFLTFVIRGYCKTALI-EDGP------------------ INP53_ScerP068_AA_1-1080 TY----RDHLDTNLKQILDDEGFLTTVIRGFAETFVS-YVKK------------------ INP52_ScerP059_AA_1-1109 TY----RDRLDVTAKELLDQRGFLTTVIRGFAETIFS-YINR------------------ Dd5P3_DdisP050_AA_45-958 AY----RLY------------DWCFPIIQGFVVSDHLGHIQG------------------ Synaptojanin_MbreP072_AA_56-790 RH----GIA----------SQDWLLPVIRGSVQIRTV-YAGS------------------ Synaptojanin_AqueP153_AA_58-806 RF----AVN----------TDRWVTPLMCGSVQIQTV-YAGD------------------ unc-26_CeleP194_AA_53-840 RY----GID----------TDNWLLKCMAGSVLVRVV-YVGA------------------ Synj_DmelP055_AA_47-494 RF----GID----------CQSWLLQAMCGSVEVRTV-YIGA------------------ SYNJ2_HsapP111_AA_41-810 QH----QVS----------CCDWLLKIICGVVTIRTV-YASH------------------ Synaptojanin_NvecP085_AA_53-869 RF----GIN----------CSEWLFSIMCGGVEIRTV-YAGV------------------ Synaptojanin_SpurP121_AA_48-803 RF----DVN----------CSDWLLKTMCGGVEVRTV-YCGT------------------ Synj_DmelP055_AA_664-825 ----------------------------KGACAIRFV--LHG------------------ SYNJ1_HsapP110_AA_91-847 HY----GVN----------CDDWLLRLMCGGVEIRTI-YAAH------------------ SAC1_MbreP071_AA_26-522 DVPEAQRHRIGLTLCTRLQAHPLLVPFAHGFFRSQELTSLSG------------------ SAC1_ScerP042_AA_2-620 NF----AHQ-------DPRIDSFIQPVIYGYAKTVDA-VLNA------------------ DDB_G0290653_DdisP053_AA_56-553 EN----SFD------------SFILPVMDGFIKITEC-EINN------------------ F30A10.6_CeleP073_AA_61-513 QVP---GAE------------RYTLPVIHGFIGQNRV-NVNG------------------ Sac1_DmelP054_AA_58-502 CD----KME------------KFQLPLVLGFVSINQV-QING------------------ SAC1_NvecP084_AA_52-521 VQP---ELQ------------RFILPVMHGFISITSC-SIKQ------------------ SACM1L_HsapP109_AA_55-506 AQP---EVH------------RFALPVLHGFITMHSC-SING------------------ SAC1_SpurP120_AA_52-503 AQP---ELG------------KFILPVMVGFISIRIG-ILNT------------------ sac1_DdisP054_AA_36-493 KE----HGL-----------GDWILPITMGFVESKTL----G------------------ DDB_G0274537_DdisP052_AA_574-105 QG----GFY------------NWVLPLIRGYVEIINF-FIER------------------ C34B7.2_CeleP032_AA_76-600 KN----LIS-----------ERWFVEIVHGYVRQEYI-FLPI------------------ W09C5.7_CeleP200_AA_52-538 EA----KIS-----------DKFTCPIMQGYVATSQL-EITD------------------ FIG4_ScerP064_AA_31-879 ACID--TVF------------DWFQCIIHGFIDQVNV-SVLG------------------ INPP5_AqueP152_AA_100-699 DN----DKT----------IDKWVLPVVQGYIEIKTI-PIPSPDQLGIFLKKQQSHDTHV FIG4_MbreP070_AA_8-476 D-----TLR-----------PEWLISLTHGFVSQSDI-NIYG------------------ CG17840_DmelP052_AA_19-586 GI----MLK------------DWLLEVTHGFVSQSCI-SIFG------------------ CG7956_DmelP053_AA_49-573 NL----NDK------------TWILPIIQGFMQVENC-VIGN------------------ FIG4_SpurP118_AA_12-598 D-----QVH-----------PCWAIHVIHGFVGQCNI-CVFG------------------ FIG4_HsapP107_AA_14-424 S-----TVH-----------RDWLLYIIHGFCGQSKL-LIYG------------------ FIG4_HsapP107_AA_229-641 S-----TVH-----------RDWLLYIIHGFCGQSKL-LIYG------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 D-----QVK----------TWYWVLPIIHGYFVQDKI-DIFG------------------ INPP5F_HsapP108_AA_49-421 EI----GTP---------DVDFWIIPMIQGFVQIEELVVNYT------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 NN----EDP---------LASSWILPVIQGYCSIVHCHNMFE------------------ INPP5_SpurP119_AA_47-407 DT----QNK--------ELARPWIIPIVQGCVQIREC-RMTF------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 ------------------------------------------------------------ INP53_ScerP068_AA_1-1080 ------------------------------------------------------------ INP52_ScerP059_AA_1-1109 ------------------------------------------------------------ Dd5P3_DdisP050_AA_45-958 ------------------------------------------------------------ Synaptojanin_MbreP072_AA_56-790 ------------------------------------------------------------ Synaptojanin_AqueP153_AA_58-806 ------------------------------------------------------------ unc-26_CeleP194_AA_53-840 ------------------------------------------------------------ Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 ------------------------------------------------------------ Synaptojanin_NvecP085_AA_53-869 ------------------------------------------------------------ Synaptojanin_SpurP121_AA_48-803 ------------------------------------------------------------ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 ------------------------------------------------------------ SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 ------------------------------------------------------------ DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 ------------------------------------------------------------ INPP5_AqueP152_AA_100-699 TTFLLGTPPKEGMATASVDVEERGGEEIKRNDRKDEHDIYSSTPLAASLPNELNDTLTQS FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 -----------------------------------------------------------V INP51_ScerP033_AA_1-946 ------------------------------NT---------------------------A INP53_ScerP068_AA_1-1080 ------------------------------LK---------------------------V INP52_ScerP059_AA_1-1109 ------------------------------LK---------------------------V Dd5P3_DdisP050_AA_45-958 ------------------------------KN---------------------------V Synaptojanin_MbreP072_AA_56-790 ------------------------------EQ---------------------------I Synaptojanin_AqueP153_AA_58-806 ------------------------------KQ---------------------------V unc-26_CeleP194_AA_53-840 ------------------------------NT---------------------------G Synj_DmelP055_AA_47-494 ------------------------------KQ---------------------------A SYNJ2_HsapP111_AA_41-810 ------------------------------KQ---------------------------A Synaptojanin_NvecP085_AA_53-869 ------------------------------SQ---------------------------A Synaptojanin_SpurP121_AA_48-803 ------------------------------RQ---------------------------A Synj_DmelP055_AA_664-825 -----------------------------------------------------------T SYNJ1_HsapP110_AA_91-847 ------------------------------KQ---------------------------A SAC1_MbreP071_AA_26-522 ------------------------------QA---------------------------Y SAC1_ScerP042_AA_2-620 ------------------------------TP---------------------------I DDB_G0290653_DdisP053_AA_56-553 ------------------------------NQ---------------------------F F30A10.6_CeleP073_AA_61-513 ------------------------------KE---------------------------I Sac1_DmelP054_AA_58-502 ------------------------------QT---------------------------F SAC1_NvecP084_AA_52-521 ------------------------------RS---------------------------F SACM1L_HsapP109_AA_55-506 ------------------------------KY---------------------------F SAC1_SpurP120_AA_52-503 ------------------------------KR---------------------------F sac1_DdisP054_AA_36-493 ------------------------------GT---------------------------C DDB_G0274537_DdisP052_AA_574-105 ------------------------------ND---------------------------I C34B7.2_CeleP032_AA_76-600 ------------------------------GR---------------------------I W09C5.7_CeleP200_AA_52-538 ------------------------------QINAY------------------------L FIG4_ScerP064_AA_31-879 ------------------------------KS---------------------------I INPP5_AqueP152_AA_100-699 NQHQLDQSITDTQSDLISFHTDSKSSQSDLKSSQIDPKSDSESSQAFVMVPNISSDVPTV FIG4_MbreP070_AA_8-476 ------------------------------RH---------------------------I CG17840_DmelP052_AA_19-586 ------------------------------RH---------------------------V CG7956_DmelP053_AA_49-573 ------------------------------EC---------------------------F FIG4_SpurP118_AA_12-598 ------------------------------RP---------------------------V FIG4_HsapP107_AA_14-424 ------------------------------RP---------------------------V FIG4_HsapP107_AA_229-641 ------------------------------RP---------------------------V DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------KG---------------------------L INPP5F_HsapP108_AA_49-421 ------------------------------ESSDDEKSSPETPPQESTCVDDIHPR---F INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------EDDMEEQSDIQIGALPPEE----------F INPP5_SpurP119_AA_47-407 ------------------------------APEEGAQSGGSGADSDDSDIK--------F INPP5_SpurP119_AA_256-568 -----------------------------------------------------------F DDB_G0279397_DdisP051_AA_271-666 SIAYLMKRSKLNPGTHFYSPGINENASPANEYESELIM---------------------- INP51_ScerP033_AA_1-946 SITIISRISTESKQDTLELEGISEDGRVSLFVETEIVV---------------TTEKFIF INP53_ScerP068_AA_1-1080 ALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIM---------------YSSQYCY INP52_ScerP059_AA_1-1109 GLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMIM---------------YSSQYCY Dd5P3_DdisP050_AA_45-958 VYTLISRRSRFRAGTRFVTRGIDDDGNVANFCESEQIL--------------SIESYGVL Synaptojanin_MbreP072_AA_56-790 CCLLVSRLSNARSGMRFNTRGVDDEGNAANFVETEQVI---------------FAGKHIL Synaptojanin_AqueP153_AA_58-806 KACLISRVSCERAGTRFNVRGLNDEGNVANFVETEQVL---------------SIDKAIA unc-26_CeleP194_AA_53-840 RVALISRLSCERVGTRFNVRGANYLGNVANFVETEQLL---------------LFDEKEC Synj_DmelP055_AA_47-494 RAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVI---------------YVDGDVT SYNJ2_HsapP111_AA_41-810 KACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMI---------------YMDDGVS Synaptojanin_NvecP085_AA_53-869 KACLISRLSCERAGTRFYVRGTDDDGHVANFVETEQMI---------------ALDDMIT Synaptojanin_SpurP121_AA_48-803 KACIVSRLSCERAGTRFNVRGTNDDGHVANFCETEQVI---------------FLDNKVT Synj_DmelP055_AA_664-825 SMCFVC--------AHFAAGQSQVAERNADYAEITRKL-------------------AFP SYNJ1_HsapP110_AA_91-847 KACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVV---------------YLDDSVS SAC1_MbreP071_AA_26-522 TFALFSRRSLGRIGTRFHSRGVRISGHCANHVESEQVL---------------VCGTAAS SAC1_ScerP042_AA_2-620 VLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQIL---------LAENPESEKIHVF DDB_G0290653_DdisP053_AA_56-553 KYIFISRRSCKRTGARYHIRGADPLGNVANFVETEQIV---------------LFDQVLT F30A10.6_CeleP073_AA_61-513 KLTIISRRSIYRAGVRFYKRGVDVDGHAANFVETEQIV------------EYTNPDKHLT Sac1_DmelP054_AA_58-502 FWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIV---------------EFNGQLT SAC1_NvecP084_AA_52-521 DFILISRRSCFRAGVRYFMRGLDGEGNAANYVETEQII---------------QFNTGTS SACM1L_HsapP109_AA_55-506 DWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIV---------------HYNGSKA SAC1_SpurP120_AA_52-503 DYILISRRSCLRAGTRFYMRGLDEQGQAANFVETEQIV---------------QFNGSRA sac1_DdisP054_AA_36-493 QFTLISRRNLNRSGTRYNVRGIDKKGNVANNVETEQII--------------EIKENTFT DDB_G0274537_DdisP052_AA_574-105 EFLLISRRSKFRAGTRYNTRGSDHNGNVANYVETEQII---------SHQDPTSGKKTTF C34B7.2_CeleP032_AA_76-600 SLTIIGRRSTKYAGTRFLKRGANPTGNVANYVETEQIV-------WDMASSGNVADGRFS W09C5.7_CeleP200_AA_52-538 TITIISRRSTRRAGARYLRRGIDEASNVANFVETELIL---------------NIFEHEL FIG4_ScerP064_AA_31-879 YITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYT INPP5_AqueP152_AA_100-699 TMALISRRSRHRAGTRYLRRGVDNEGHVANFVETEMLL---------------LAATHLL FIG4_MbreP070_AA_8-476 YVTLIARRSRHYAGTRFLKRGCDNAGHCANHVESEQIV--------HDASEISHRRAFIT CG17840_DmelP052_AA_19-586 NVCLVARRSSRFAGTRFLKRGANFQGDVANEVETEQIV---------------SDGQRIC CG7956_DmelP053_AA_49-573 TLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQIL---------------SFRHHQL FIG4_SpurP118_AA_12-598 LMTLVARRSAHYAGTRFLKRGANSEGGVANEVETEQIV--------HEASLSELKRGRFA FIG4_HsapP107_AA_14-424 YVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQIL--------CDASVMSFTAGSYS FIG4_HsapP107_AA_229-641 YVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQIL--------CDASVMSFTAGSYS DDB_G0281427_DdisP049_AA_556-710 -------------------------------IGTEQI----------------------- DDB_G0281427_DdisP049_AA_76-502 DLILIARRSRYYAGARFLKRGINENGQVANDVETEQIL--------QEPLTGWSSKAKFS INPP5F_HsapP108_AA_49-421 LVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLI---------------HVHNHTL INPP5F_HsapP108_AA_278-570 -VALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLI---------------HVHNHTL INPP5_NvecP083_AA_48-587 DLLLISRRSIFRAGTRYKRRGVDDDGEVANYVETEQIV---------------RTEIHSV INPP5_SpurP119_AA_47-407 NLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQIL--------------Q-TAEHSV INPP5_SpurP119_AA_256-568 NLMLISRRSKFRAGTRYRRRGIDESGACANYVETEQIL---------------QTAEHSV DDB_G0279397_DdisP051_AA_271-666 ------------WKV----------------------QDKQSILINNIASSSNSNLSDLD INP51_ScerP033_AA_1-946 SYTQVNGSIPLFWES---------------VESQLLYGKKIKVTKDSIEAQGAFDR-HFD INP53_ScerP068_AA_1-1080 AFTQIRGSIPVFWEQ---------------GTSL--INPRVQITRSFEATQPVFDK-HIM INP52_ScerP059_AA_1-1109 AFTQIRGSLPIFWEQ---------------DTSL--ISPKIQITRSVEATQPTFDE-HFI Dd5P3_DdisP050_AA_45-958 AFLQIRGSVPVFWNQSSPQMSDLKIKMSNLSKIGKISKKKITIARNTQATTPAFQL-HLK Synaptojanin_MbreP072_AA_56-790 SFVIARGSVPIFWSQ---------------PGLNV-GQHKVQLTREFAATQPAFQR-HFD Synaptojanin_AqueP153_AA_58-806 SFVQVRGLVPVFWDQ---------------PGIQT-GTNRIRLSRGFHCSHAAFVR-HFE unc-26_CeleP194_AA_53-840 SLLQIRGSIPLFWEQ---------------PGVNV-GSHKVKL-RAFETSLPAYHR-HLS Synj_DmelP055_AA_47-494 SYVQTRGSVPLFWEQ---------------PGVQV-GSHKVKLSRGFETSAAAFDR-HMS SYNJ2_HsapP111_AA_41-810 SFVQIRGSVPLFWEQ---------------PGLQV-GSHHLRLHRGLEANAPAFDR-HMV Synaptojanin_NvecP085_AA_53-869 SFVQTRGSVPVFWEQ---------------PGIQV-GSHKVKLSRGFEAASAAFDR-HLT Synaptojanin_SpurP121_AA_48-803 SFIQTRGSVPLFWEQ---------------PGINV-GVHKVKMSRGFEASAPAFDR-HLT Synj_DmelP055_AA_664-825 MGRTLKSHDWVFWCG----------------------DFNYRIDMEKDELKECVRN---- SYNJ1_HsapP110_AA_91-847 SFIQIRGSVPLFWEQ---------------PGLQV-GSHRVRMSRGFEANAPAFDR-HFR SAC1_MbreP071_AA_26-522 CFVQVRGSIPLCWSQ--------------PPDLR--YKPPFRMS-EYDDSNLACQR-HLS SAC1_ScerP042_AA_2-620 SFLQTRGSVPIYWAE--------------INNLK--YKPNLVLGENSLDATKK----HFD DDB_G0290653_DdisP053_AA_56-553 SFVQVRGSIPLIWQQ---------------KGKG--LKPRPIVE-NSVQTDDAFTS-HMN F30A10.6_CeleP073_AA_61-513 SFVQLRGSIPLLWTQ--------------KPNLR--WQPMPTL-KPTDDQLAAFNR-AFS Sac1_DmelP054_AA_58-502 GFVQTRGSMPFHWHQ--------------LPNLR--YKPRPVL-VPGKDHLAACGL-HFK SAC1_NvecP084_AA_52-521 SFVQIRGSIPLYWTQ--------------RPNLK--YKPKPQVN-SSADHSLGFQY-HID SACM1L_HsapP109_AA_55-506 SFVQTRGSIPVFWSQ--------------RPNLK--YKPLPQISK-VANHMDGFQR-HFD SAC1_SpurP120_AA_52-503 SFVQTRGSIPLFWSQ--------------RPNLK--YKPVPHIS-ESQSHLDAFKR-HFD sac1_DdisP054_AA_36-493 SFVQVRGSIPLLWSQ--------------FPTLK--YKPSVKFYGDEKENSQALEQ-HFK DDB_G0274537_DdisP052_AA_574-105 SFVQTRGSIPLIWEQ---------------TGRK--IKPEIKITQDNQLNSNSFRA-HFD C34B7.2_CeleP032_AA_76-600 SFVQMRGSVPMRWSQ---------------DPSTRGVVGKPLILIDNHEPHAQTAASHFR W09C5.7_CeleP200_AA_52-538 SFVQCRGSIPVFWSQ---------------RGFK--YRPPLIINRSVEETHGVFTE-HFK FIG4_ScerP064_AA_31-879 SFVQHRGSIPLYWTQ---------------DASN--LTTKPPIRINVVDPFFSPAALHFD INPP5_AqueP152_AA_100-699 SFIVVRGSVPVYWTQ---------------PGNR--YRPLPIIEQTDEETAVAFER-HFE FIG4_MbreP070_AA_8-476 SYIQMRGSVPVHWEQ---------------DHAG--MKAKPPISIARADPFASAAAMHFE CG17840_DmelP052_AA_19-586 AFTQMRGSIPSHWSQ---------------DISK--MVPKPQIQLDICDPYAQTPSLHFE CG7956_DmelP053_AA_49-573 SFTQVRGSVPIYWSQ---------------PGYK--YRPPPRLDRGVAETQQAFEL-HFT FIG4_SpurP118_AA_12-598 SYVQHRGSVPALWSQ---------------DITT--MVPKPPINIDMADPFAHLAGRHVN FIG4_HsapP107_AA_14-424 SYVQVRGSVPLYWSQ---------------DIST--MMPKPPITLDQADPFAHVAALHFD FIG4_HsapP107_AA_229-641 SYVQVRGSVPLYWSQ---------------DIST--MMPKPPITLDQADPFAHVAALHFD DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 SFVQIRGSIPLYWEQ---------------DNNI--MTPKPPIKIQRMDPFLGSTILHFQ INPP5F_HsapP108_AA_49-421 SFVQTRGSVPVFWSQ---------------VGYR--YNPRPRLDRSEKETVAYFCA-HFE INPP5F_HsapP108_AA_278-570 SFVQTRGSVPVFWSQ---------------VGYR--YNPRPRLDRSEKETVAYFCA-HFE INPP5_NvecP083_AA_48-587 SFVQVRGSVPVFWSQ---------------PGYK--YRPPPRLDKDEMDTQAAFRH-HFS INPP5_SpurP119_AA_47-407 SFVQVRGSVPVFWSQ---------------PGIK--YKPPPRIDRDDDESQEAFKT-HFE INPP5_SpurP119_AA_256-568 SFVQVRGSVPVFWSQ---------------PGIK--YKPPPRIDRDDDESQEAFKT-HFE DDB_G0279397_DdisP051_AA_271-666 KKSNSNNNNNNN-----------NNNNNNNNNNNSTSTASTTATATAISSSL-SISSTTA INP51_ScerP033_AA_1-946 NLTSKYG---VVSIV--NIIK--PKSESQEKLALTYKD--------CAESKGIKITNIEY INP53_ScerP068_AA_1-1080 KSVEKYG--PVH-VV--NLL---STKSSEIELSKRYKE-HLTHSKKLNFNK--DIFLTEF INP52_ScerP059_AA_1-1109 RLFKKYG--PVH-II--NLL---STKSSEIQLSRRYKE-QLKNSEKMKIGR--DVFLTSF Dd5P3_DdisP050_AA_45-958 EQTKKYG--NIV-IV--NLLS--KLKSGECDLVNAYEE-QI-----RILRSP-QVFYNHF Synaptojanin_MbreP072_AA_56-790 QLAAAYG--HTV-IV--SLL---GLKGGEYTLESQFEK--------HASTYDPDMPFVHF Synaptojanin_AqueP153_AA_58-806 SLLSQYG--PCL-CV--DLL---GNRDMEPLLTEAYVD-HLRNLEEEVPGAA---EYVQF unc-26_CeleP194_AA_53-840 QLQHRYG--EFA-IV--NLL---GRKEGERVLGDAFKTQHK-----SSHFAP-LVDFIDF Synj_DmelP055_AA_47-494 MMRQRYGYQTVVNLLGSSLV---GSKEGEAMLSNEFQR-HH-----GMSAHK-DVPHVVF SYNJ2_HsapP111_AA_41-810 LLKEQYG--QQV-VV--NLL---GSRGGEEVLNRAFKK-LL-----WASCHAGDTPMINF Synaptojanin_NvecP085_AA_53-869 TQKGLYG--DVC-IV--NLL---GMKEGENALSRIFQD-ELT----ESIHGH-DTPMICF Synaptojanin_SpurP121_AA_48-803 MVKAHYG--DQV-IV--NLL---GSKEGEDMLSKSFQN-HL-----KASSHDQDTPHILF Synj_DmelP055_AA_664-825 ------G--DLSTVL--EF----DQLRKEQEAGNVFGE-FLEGEITFDPTYKYDLFSDDY SYNJ1_HsapP110_AA_91-847 TLKNLYG--KQI-IV--NLL---GSKEGEHMLSKAFQS-HL-----KASEHAADIQMVNF SAC1_MbreP071_AA_26-522 DLCTRFG--PCL-CI--NLV---NKTGSEGILGSRFQD-VL-----QSIERALPIKSEWF SAC1_ScerP042_AA_2-620 QQKELYG--DNY-LV--NLV---NQKGHELPVKEGYES-VV-----HALNDP-KIHYVYF DDB_G0290653_DdisP053_AA_56-553 ELIQLYG--PTV-II--SLI---DQIGGEASIGDAFESETL-----LMYPKE-MVKYVAY F30A10.6_CeleP073_AA_61-513 WHKQHYG-GKHV-IV--NLV---NQKGREKKVGGELER-IS-----RQANIE-FVRYHQF Sac1_DmelP054_AA_58-502 EQIRLYG--NNV-AV--NLV---DHKGAEGELEATYAR-LV-----REMGNP-QVRYESF SAC1_NvecP084_AA_52-521 NEIAHYK--ELV-LI--NLI---DQKGPEKVLGDRFST-II-----RNSPYK-ETSYEAF SACM1L_HsapP109_AA_55-506 SQVIIYG--KQV-II--NLI---NQKGSEKPLEQTFAT-MV-----SSLGSG-MMRYIAF SAC1_SpurP120_AA_52-503 DQVVNYG--NQV-LI--NLI---DHKGAENRLEKMFAK-TV-----YESGNQ-MMRYEAF sac1_DdisP054_AA_36-493 QLHQLYGSTTVV-----NLI---DRKGAELKLGEAYEE--------RVKSLK-DVHYVWF DDB_G0274537_DdisP052_AA_574-105 EQIKLYGPGPQV-LV--TLL---DQKGSEAELGEAYRM-MA-----VTSGYR-EIDFVPF C34B7.2_CeleP032_AA_76-600 DVRNKYG-NPIV-IM--NLIKRNEKRRHEGVLHTQFLK-NIEYLNQFLPNEE-KLCYISF W09C5.7_CeleP200_AA_52-538 RLKAHYD-TPLV-AV--SLV---DQRGRELPLAQRFLE-HC-----VKADDN-DVTFFSF FIG4_ScerP064_AA_31-879 NLFQRYGGGTIQ-IL--NLIKTKEKTPRETKLLWEFEQ-CIDYLNEFLPTLK-KLDYTSW INPP5_AqueP152_AA_100-699 SQMNLYR--EQV-IV--NLI---NQSGRERIVSTAFEK-QL-----LTLDCP-SLTYVAF FIG4_MbreP070_AA_8-476 RLFHKFG-APII-AF--DLVKKKERRPRESILLNAYTA-ALGYLNKFLPKES-AIQHVSW CG17840_DmelP052_AA_19-586 RLLFHYG-APLI-ML--NLVKKRERRKHESIISKELEY-SIRYLNQFLPPPH-RMKHIHF CG7956_DmelP053_AA_49-573 KELETYG--RVC-IV--NLV---EQSGKEKTIGDAYAD-HV-----IKLNND-RLIYVTF FIG4_SpurP118_AA_12-598 DLFSRFG-SPVI-VV--NLVKKREKRKRESHLTEALSA-SLSYLNQFLPPKH-QVQYIHL FIG4_HsapP107_AA_14-424 QMFQRFG-SPII-IL--NLVKEREKRKHERILSEELVA-AVTYLNQFLPPEH-TIVYIPW FIG4_HsapP107_AA_229-641 QMFQRFG-SPII-IL--NLVKEREKRKHERILSEELVA-AVTYLNQFLPPEH-TIVYIPW DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 DLFQRFG-SPII-IL--NLVKSNEKKPRESILRNEFTD-CINCLNEMLPEQH-RIHYQAW INPP5F_HsapP108_AA_49-421 EQLNIYK--KQV-II--NLV---DQAGREKIIGDAYLK-QV-----LLFNNS-HLTYVSF INPP5F_HsapP108_AA_278-570 EQLNIYK--KQV-II--NLV---DQAGREKIIGDAYLK-QV-----LLFNNS-HLTYVSF INPP5_NvecP083_AA_48-587 HQLSLYG--GVV-VV--NLV---DQTGREKIISDVFMR-HI-----LAYNCP-LLTYITF INPP5_SpurP119_AA_47-407 EDLQRYR--HVA-II--SLI---EQAGREAIVGSAFMK-HV-----LLYDSP-KLTYITF INPP5_SpurP119_AA_256-568 EDLQRYR--HVA-II--SLI---EQAGREAIVGSAFMK-HV-----LLYDSP-KLTYITF DDB_G0279397_DdisP051_AA_271-666 SLSLSSS--STAP-NTITTT--STAIPKVDLNK------------NN--DTDDS---NNN INP51_ScerP033_AA_1-946 SSSVLTK--SPHK---------LLYLLKQDIYE------------FGAFAYDISRGIYFA INP53_ScerP068_AA_1-1080 DFHKETS--QEGF-SGVRKL--IPLILDS-LLS------------SGYYSYDVREKKNIS INP52_ScerP059_AA_1-1109 DFHRETS--QDGF-AAASRI--IPKIRNT-ILD------------AGYFSYDVK-EGRLI Dd5P3_DdisP050_AA_45-958 DLNEQTK--GNRM-DPLDSL--INYIDNQSISGGGGTTGGVSEKIVGYFFQNSN--GQII Synaptojanin_MbreP072_AA_56-790 DVHAKCR--GNKKAVKMLPL--VKQLRTW-LTS------------DSFFSLTGK---RVN Synaptojanin_AqueP153_AA_58-806 DYHGHCR--PKHN-EALETI--LLPMCSRFIDT------------CSYYLETDG---EVV unc-26_CeleP194_AA_53-840 DYHAQMK--ISK--EAIVQL--KKKMSPH-MTK------------HGFFYSMGK---EIV Synj_DmelP055_AA_47-494 DYHQECR--GGNF-SALAKL--KERIVAC-GAN------------YGVFHASNG---QVL SYNJ2_HsapP111_AA_41-810 DFHQFAK--GGKL-EKLETL--LRPQLKLHWED------------FDVFTKGENVSPR-- Synaptojanin_NvecP085_AA_53-869 DYHRNCK--GGRT-SKLKDF--ADKARQL-FNS------------NSLFFSKGG---KLE Synaptojanin_SpurP121_AA_48-803 DYHQMCR--GKV--DNLPLL--KKKVATE-MDQ------------FGFFFSEGG---EVI Synj_DmelP055_AA_664-825 DTSEKQR--APAW----------------------------------------------- SYNJ1_HsapP110_AA_91-847 DYHQMVK--GGKA-EKLHSV--LKPQVQKFLD-------------YGFFYFNGS---EVQ SAC1_MbreP071_AA_26-522 DFHHECR--NMQW-QHLAKL--KASTSNW-RQH------------QGISTMSLT-SGRLA SAC1_ScerP042_AA_2-620 DFHHECR--KMQW-HRVKLL--IDHLEKLGLSN------------EDFFHKVIDSNGNTV DDB_G0290653_DdisP053_AA_56-553 DFHEKCK--NNRY-DRLSEL--LNSVKPL-VDQ------------YGYLFKSTMIGIEPT F30A10.6_CeleP073_AA_61-513 DFHKECH--SMQW-HRIDLL--REQLSQE-ISS------------FGYFYLSPNSMETSR Sac1_DmelP054_AA_58-502 DFHSECR--KMRW-DRLNIL--IDRLAHE-QDQ------------FGVYHVFDD--GKLV SAC1_NvecP084_AA_52-521 DFHKECS--KMRW-DRLNLL--IDRLSPD-QKK------------FGYFSMGKD--KDIQ SACM1L_HsapP109_AA_55-506 DFHKECK--NMRW-DRLSIL--LDQVAEM-QDE------------LSYFLVDSA--GQVV SAC1_SpurP120_AA_52-503 DFHHECR--KMRW-DRLSIL--MDKLAKD-QQQ------------FGYFWMDAN--NELL sac1_DdisP054_AA_36-493 DFHSICK--GMRY-DKLSIL--MDQLKDD-LKQ------------YGFFFVEDG---KIV DDB_G0274537_DdisP052_AA_574-105 DFHHFCQ--GNRF-DRVDIL--IDQLEENIHQH------------IGYTERNSE--QGYT C34B7.2_CeleP032_AA_76-600 DVARCNK--AANSMPSINVLNVMEDLSMKSILK------------NGWFQSFPLSEALKI W09C5.7_CeleP200_AA_52-538 DLHQHCR--GLNF-QKLQTL--ISSMEET-LKT------------IGFCWVDKT--GEVV FIG4_ScerP064_AA_31-879 DMSRASK--QDGQ-GVIEFL--EKYAVNT-VTT------------TGIFHNGPDFASTK- INPP5_AqueP152_AA_100-699 DFHHHCK--VNQW-HNINLL--LSNIEQY-ITR------------QKYFWIDNDEGSSGQ FIG4_MbreP070_AA_8-476 DMAKSNK--SREP-VVLRIL---DQYAQHFLKQ------------QGIFTSRQRLSLVAE CG17840_DmelP052_AA_19-586 DMARQSRLSGGNVMEQLAIH--AESIVQM----------------TGMFFKAAGSEPG-- CG7956_DmelP053_AA_49-573 DFHDYCR--GMRF-ENVSAL--IDAVGPE-AGA------------MGFHWRDQR---GMI FIG4_SpurP118_AA_12-598 DMARYTK--NKNA-DVMSKL---EKIASRSVEK------------TGIFLSGHAIHPSIP FIG4_HsapP107_AA_14-424 DMAKYTK--S-------------------------------------------------- FIG4_HsapP107_AA_229-641 DMAKYTK--SKLC-NVLDRL--NVIAESV-VKK------------TGFFVNRPDSYCSIL DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 DFHQAAK--SKDE-DHMAWL---DSFANQSILK------------TGIFYS--------- INPP5F_HsapP108_AA_49-421 DFHEHCR--GMKF-EN-------------------------------------------- INPP5F_HsapP108_AA_278-570 DFHEHCR--GMKF-ENVQTL--TDAIYDI-ILD------------MKWCWVDEA---GVI INPP5_NvecP083_AA_48-587 DFHEYCR--GMKF-ENVSVL--VDSIGDV-IKD------------MRYCWTDPK---GII INPP5_SpurP119_AA_47-407 DFHEYCR--GLRF-D--------------------------------------------- INPP5_SpurP119_AA_256-568 DFHEYCR--GLRF-DKVSVL--LESIRDV-IKE------------MRYCWADAE---GVI DDB_G0279397_DdisP051_AA_271-666 N-------------------NSNGGLTNNTTNIIPNNNNINEKVIQWTSHVWRRGTV--- INP51_ScerP033_AA_1-946 --------------------KQTGVLRISAFDSIEKPNTVERLVSKEVLELTTNEID--- INP53_ScerP068_AA_1-1080 --------------------EQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFR--- INP52_ScerP059_AA_1-1109 S-------------------EQDGVFRTNCLDCLDRTNLIQQTISLAVFKLFLEDFR--- Dd5P3_DdisP050_AA_45-958 S-------------------KQNGIIRTNCKDCLDRTNIVQSRVSWVLFESQLRKLG--- Synaptojanin_MbreP072_AA_56-790 H-------------------EQLGIIRVNCLDCLDRTNLCQSVVGLAVLEDMLGTLK--- Synaptojanin_AqueP153_AA_58-806 S-------------------AQTGVLRVNCLDCLDRSNNSQAMFGQQLLVQQLDGLK--- unc-26_CeleP194_AA_53-840 K-------------------RQTGVIRTNCLDCLDRTNAVQTAIGLQMSHDQVAFLN--- Synj_DmelP055_AA_47-494 R-------------------EQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALK--- SYNJ2_HsapP111_AA_41-810 --------------------FQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLG--- Synaptojanin_NvecP085_AA_53-869 K-------------------RQKGVMRSNCLDCIDRTNNMQTFIGLEMLLVQLQCLG--- Synaptojanin_SpurP121_AA_48-803 R-------------------QQTGTIRSNCLDCLDRTNAVQTFFGQDMLAKQLEALG--- Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 R-------------------CQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALG--- SAC1_MbreP071_AA_26-522 H-------------------RQKGVIRTNCIDVLDRTNVVQTMFAQDALLLQLQHLAEFL SAC1_ScerP042_AA_2-620 EIVN----------------EQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESAD--- DDB_G0290653_DdisP053_AA_56-553 I-------------------QQSGCFRTNCIDCLDRTNVVQSVLAHYILHSQLTRMG--- F30A10.6_CeleP073_AA_61-513 --------------------FQRGFFRTNCMDCLDRTNVVQSMLARESLTEQLRMLG--- Sac1_DmelP054_AA_58-502 S-------------------TQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLG--- SAC1_NvecP084_AA_52-521 S-------------------EQKGVFRTNCIDSLDRTNVVQSMLARNSLQLQLEEYG--- SACM1L_HsapP109_AA_55-506 A-------------------NQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLG--- SAC1_SpurP120_AA_52-503 K-------------------HQVGVFRTNCMDCLDRTNVVQSMLARRALQDQMQQMG--- sac1_DdisP054_AA_36-493 Q-------------------KQQGVFRTNCIDNLDRTNVVQSLITRHSLENQMASVL--- DDB_G0274537_DdisP052_AA_574-105 Q-------------------HQHGLTRTNCLDCLDRTNLVQSMIGVSVLERQLKRLG--- C34B7.2_CeleP032_AA_76-600 RPREAFATLDAHHSKDGRFMIQHGICRTNCVDCLDRTNVAQFVIAKVALGCQLCAMG--- W09C5.7_CeleP200_AA_52-538 Q-------------------SQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQRLG--- FIG4_ScerP064_AA_31-879 --------------------IQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLG--- INPP5_AqueP152_AA_100-699 PLC-----------------YQNGVFRVNCMDCLDRTNVVQSVICKEFIQTALQKLG--- FIG4_MbreP070_AA_8-476 ADAGLD--------------SGHGVVRVNCVDCLDRTNTAQFMIGLCALRHQLFELG--- CG17840_DmelP052_AA_19-586 --------------------LQTGIVRTNCVDCLDRTNSAQFAIGKCALGHQLERLG--- CG7956_DmelP053_AA_49-573 C-------------------NQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLG--- FIG4_SpurP118_AA_12-598 VREGARTDIPQEGSCEQVFIRQMGVVRTNCVDCLDRTNTAQFVTGKYALGHQLYSLG--- FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 RPDEKWNELGGCVIPTGR--LQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLG--- DDB_G0281427_DdisP049_AA_556-710 -----------------------GVVRTNCIDSLDRTNAAQFCIGKCALGYQLYSMG--- DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 C-------------------KQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLG--- INPP5_NvecP083_AA_48-587 C-------------------EQRSVFRVNCMDCLDRTNVVQAALARHLLEMQLRKLG--- INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 L-------------------EQRGVFRVNCMDCLDRTNVVQTALARVVLRTQLRKLG--- DDB_G0279397_DdisP051_AA_271-666 PL-----WWRAFSK--NQGSNEIELFLKDRGKENPNPFEKSESYYQNLLNRYEKFYQENK INP51_ScerP033_AA_1-946 -----------VFELTSPFLDAHDKLWSENYYWLDRTYTKHTKNSGKYTKVYSKLFGSRV INP53_ScerP068_AA_1-1080 LI------SSNSFIDDDDFVSKHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSLAGAL INP52_ScerP059_AA_1-1109 LV------KPSSFIDDNEFVQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFSGAL Dd5P3_DdisP050_AA_45-958 LF-----RGHDSIGSYPRVSQTLKTTWADNGDALSIQYAGSGSLKSTLTREGDYGIMGML Synaptojanin_MbreP072_AA_56-790 SE------LDLRESKLLEFRRVFALMWSVNGDNVSRCVTGTGAISGGVK-------TSKL Synaptojanin_AqueP153_AA_58-806 LS------SKVNVL--SRFKQIFERFWMQNGDNISKLYAGTRAL-------GSSSKVSKL unc-26_CeleP194_AA_53-840 LN-----AGKVNVE--QRVEEILRDLWQKNGDQCSTIYAGTGALDG----------KSKL Synj_DmelP055_AA_47-494 M------GGKQQNI--SRFEEIFRQMWINNGNEVSKIYAGTGAIQG----------GSKL SYNJ2_HsapP111_AA_41-810 ---------LSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEG-------KAKVGKL Synaptojanin_NvecP085_AA_53-869 LG------SKASLV--PRFQEAFTSMWSQNGDHISRIYIGTGAL------DGKARVASKL Synaptojanin_SpurP121_AA_48-803 --------VSSKPQIMSRFLETYKTIWGLSGDHISRIYAGTGALEG-------KTKAGKL Synj_DmelP055_AA_664-825 ---------------------TDRVLWRRRKA---------------------------- SYNJ1_HsapP110_AA_91-847 --------LAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALEG----------KAKL SAC1_MbreP071_AA_26-522 NLAPTTATESALATSWPGLLTTFRGTWADHADEISIQYAGTPAQKSDFTRTGKRTLRGTL SAC1_ScerP042_AA_2-620 VVATGSTWEDNAP-----LLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAF DDB_G0290653_DdisP053_AA_56-553 II-----GANERIEDHQQFETQFKNIWADNADVMSEQYTGTVALKTDFTRTGKRSVKGTM F30A10.6_CeleP073_AA_61-513 IL-----YSEQKVQDIPLLEDAFKQMWADNGDECSRQYAGTGALKADFTRHGRRTYVGAM Sac1_DmelP054_AA_58-502 VL----HVGQKVEHASDIFESIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAM SAC1_NvecP084_AA_52-521 VL-----ATGERIVDHNDFEYTFKNVWADNADACSVQYAGTGALKTDFTR--QEVLFGAM SACM1L_HsapP109_AA_55-506 VL-----HVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLI SAC1_SpurP120_AA_52-503 IL---KQGENLDDHYTAAFESTFKNTWADNADACSKQYAGTGALKTDFTRTGKRTKFGLL sac1_DdisP054_AA_36-493 NK---QIPSTTFKG--DQFEYVFKNIWADHGDAISTQYSGTGALKNDFTRTGKRNFQGVL DDB_G0274537_DdisP052_AA_574-105 FE-----WRIKDQS--LPGTRSIKLAWANNGDAISFQYAGTQALKGDYTRTGKRNTKGVF C34B7.2_CeleP032_AA_76-600 IL------DEPNLTLQSEVCRLLEDMFDEHGDTMALQYAGSQLVHSIKTYKKTAAFQERR W09C5.7_CeleP200_AA_52-538 IF-----GPLCEPP--EVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVM FIG4_ScerP064_AA_31-879 II------DNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHS INPP5_AqueP152_AA_100-699 LI-------DPFTSLTGQFLRHYQELWANNGDTISRQYTGTDAMKGDLTRYGQRRLYGVM FIG4_MbreP070_AA_8-476 VI---ADTQASQIPPDSPVNRVLEEMYEDHGDTIALQYGGSQLVNRIQSYRKTRPWTSNS CG17840_DmelP052_AA_19-586 FV------KSAKLEFDSDCVTMLENLYEEHGDTLALQYGGSQLVHRIKTYRKTAPWGSQG CG7956_DmelP053_AA_49-573 LS-----PPYTPIP--EQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMM FIG4_SpurP118_AA_12-598 VV------ADPELEFDSDVVRMLEDLYEDMGDTLALQYGGSQLVHSISTYRKIAPWTSHS FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 LI------DKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHS DDB_G0281427_DdisP049_AA_556-710 LL------DSPSLDFNTGIVQVLIDMYEACGNQIALQYGGSELANTIKTYT-KHSLSSQS DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 VM-----PPEQPLP--VKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVM INPP5_NvecP083_AA_48-587 -------KLMPDQTLPASIRAPFKEMWANNGDAISRQYAGTAALKGDFTRTGERKFTGLM INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 LL-------LPEQRLVPSIKTIYQDMWANNGDIVSRQYAGTAALKGDYTRTGERKLTGLM DDB_G0279397_DdisP051_AA_271-666 D--TNLAGIPTIQLINLLKQEN-DKQEVILS----------------------------- INP51_ScerP033_AA_1-946 RLYDPLHIYISQYLKQLRSKYTFEKDISIFA----------------------------- INP53_ScerP068_AA_1-1080 S--DATKSVSRIYINNFMDKEK-QQNIDTLL------------------------GRLPY INP52_ScerP059_AA_1-1109 S--DATKSVSRMYINNFVDKGK-QQNIDTLL------------------------GKLPH Dd5P3_DdisP050_AA_45-958 A--DGKKTMTRFYINNFKDPGR-QDVLDLLL--------------GLHKSMVVNNSNNGN Synaptojanin_MbreP072_AA_56-790 K--DMQRSVVRTFKNNFMDSRR-QAAIDLLLGTYRDGQADELVIPNVLMRQRLDEAMRLR Synaptojanin_AqueP153_AA_58-806 R--NSARSVQRTIVNNFMDSSK-QEAIDLLL----------------LNGYVGEIGIQTR unc-26_CeleP194_AA_53-840 K--DASRSLARTIQNNLMDGAK-QESFDLFL---------TGAAYDPRLFDRACNILPPS Synj_DmelP055_AA_47-494 M--DGARSAARTIQNNLLDNSK-QEAIDVLLV---------------------------- SYNJ2_HsapP111_AA_41-810 K--DGARSMSRTIQSNFFDGVK-QEAIKLLL---------------VGDVYGEEVADKGG Synaptojanin_NvecP085_AA_53-869 R--DGARSVKRTIRSNFLDGSK-QEAIDLLL-------LGNTFVGELGERARALLYSSFL Synaptojanin_SpurP121_AA_48-803 R--DGARSVTRTIQNNFFDGTK-QESIDVLL---------------LGSSLVGSLANKAS Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 K--DGARSVTRTIQNNFFDSSK-QEAIDVLL-------LGNTLNSDLADKARALLTTGSL SAC1_MbreP071_AA_26-522 R--DLYHSALRYFHNNFLDGGK-QDALLLLT----------------------------- SAC1_ScerP042_AA_2-620 N--DFLNSASRYYQNNWTDGPR-QDSYDLFL----------------------------- DDB_G0290653_DdisP053_AA_56-553 T--DGVNSVRRYINKNFKDDEK-QSAIDLFL----------------------------- F30A10.6_CeleP073_AA_61-513 K--DGVNAVSRYVRNNFGDGYR-QDSIDLFL----------------------------- Sac1_DmelP054_AA_58-502 Q--DGKNSLMRYYLNNFADGQR-QDSIDLFL----------------------------- SAC1_NvecP084_AA_52-521 R--DGVNSIVTCFIHIFFSM---QDSIDLFL----------------------------- SACM1L_HsapP109_AA_55-506 M--DGWNSMIRYYKNNFSDGFR-QDSIDLFL----------------------------- SAC1_SpurP120_AA_52-503 K--DGMNSLIRYYMNNFVDGFR-QDSTDLLL----------------------------- sac1_DdisP054_AA_36-493 R--DGENSVKRYYLNNFKDGFR-QDSYFLFT----------------------------- DDB_G0274537_DdisP052_AA_574-105 R--DGVNSLTRYYINNFLDKIR-QVSIDLFL----------------------------- C34B7.2_CeleP032_AA_76-600 R--DVFQTLSRYYSNTFNDWDK-QMAINLFL----------------------------- W09C5.7_CeleP200_AA_52-538 K--DGYNSASRYYLTHTKDAQR-QKAINIVT----------------------------- FIG4_ScerP064_AA_31-879 R--DMIESIKRFYSNSFVDAQR-QDAINLFL----------------------------- INPP5_AqueP152_AA_100-699 K--DGYNSAHRYLQSLFRDAYR-QVVIDLQ------------------------------ FIG4_MbreP070_AA_8-476 R--DILNTVARYYSNSFTDADK-QMAINLFL----------------------------- CG17840_DmelP052_AA_19-586 S--DVMQTLSRYYSNTFSDTEK-QHSINLFL----------------------------- CG7956_DmelP053_AA_49-573 K--DGMNSANRFFIQNFADSFR-QCIIDLMQ----------------------------- FIG4_SpurP118_AA_12-598 R--DIKQTLSRYYSNAFSDNDK-QSAINLFL----------------------------- FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 K--DIMQTLSRYYSNAFSDADR-QDSINLFL----------------------------- DDB_G0281427_DdisP049_AA_556-710 R--DLVNAIKRYISNSFIDADK-QHSINLFL----------------------------- DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 K--DGVNSANRYYLNRFKDAYR-QAVIDLMQ----------------------------- INPP5_NvecP083_AA_48-587 K--DGYNSANRYYLNRFKAAYR-QTLIDMML----------------------------- INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 K--DGYNSASRYVQNQLKDAFR-QVAIDLML----------------------------- DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 -----------------------------------GTFNISGKIPKDDIKDWIFPKSMSK INP53_ScerP068_AA_1-1080 QKAVQLYDPVNEYVSTKLQSMSDKFTSTSNINLLIGSFNVNGATKKVDLSKWLFPIGEKF INP52_ScerP059_AA_1-1109 QQVVELYDPICEYVNERLLESEEKFTTHSNINLFVGTFNVNGNSRRADLSKWLFPIGDKF Dd5P3_DdisP050_AA_45-958 GGNGGNGSGHDDNIRKQVQDRVKEYSKKEWRNVFVGTYNVGGVHSSYFDLVQWLRPDGAN Synaptojanin_MbreP072_AA_56-790 INDYSDVMPINGLCIDEWLIRPRSRLSEDQGN---------------------------- Synaptojanin_AqueP153_AA_58-806 NLLKPADLLASLPLRKSLTERWQEYTSTEKLRVCVGTWNVNGGKQMRSIALKKESMHDWL unc-26_CeleP194_AA_53-840 LIQESYYYHEYADAVSQLVERSPEIAEPQSIKIFVGTWNVNGGKNIHNVAFRNESSLSHW Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 MLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWL Synaptojanin_NvecP085_AA_53-869 H--------SSPRILRELCDRHLEYTTWSNIRVCVGTWNVNGGRHFRSLAHKHQTMHDWL Synaptojanin_SpurP121_AA_48-803 SLLPSSHLHASPDILQGVCEREGDFTSSSRFRICVGTWNVNGGKNSHNIAFKNESLTDWL Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 RVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWL SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 ------------------------------------------------------------ DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 ----------------------------------------------GHYSWREGFPSLWE INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 EDE-------------------MADLYVIGLEEVVELTPGHMLATDPYVRQFWEKKILTL INP53_ScerP068_AA_1-1080 ----------------------KPDIVVLGLQEVIELSAGSILNADYSKSSFWENLVGDC INP52_ScerP059_AA_1-1109 ----------------------KPDVVVLGLQEVIELTAGSILNADYTKSSFWETMVTDC Dd5P3_DdisP050_AA_45-958 CP--------------------TPDFYVLGLQEVVELTAGQILATDSSIGKQWEDAIERA Synaptojanin_MbreP072_AA_56-790 ----------------------ELGIYAIGFQEMVDLNASNMIKTAQTNRLEWANEICTI Synaptojanin_AqueP153_AA_58-806 LDAPVLSGKKSIP---------PADVYAIGFQELVALTTSNLVSTNSSNRYAWAAELQHV unc-26_CeleP194_AA_53-840 IFANSMTRLVSVEDEQ------LADIVAIGVEELVDLNASNMVKASTTNQRMWCESIRKT Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 LDSPQLSGATDSQDDSS-----PADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKA Synaptojanin_NvecP085_AA_53-869 LDFHKSLPDSGYSEVKDVDYSLPTDIFAIGFEELVDLNASNMVSTSSTQRKEWGEELRRV Synaptojanin_SpurP121_AA_48-803 LDNPQITGVDYSV---------PNDIYAIGFEEMVDLNAGNIISASTTNQRKWGVELQKS Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 LDAPKLAGIQEFQDKRSK----PTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKT SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 ------------------------------------------------------------ DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 MNTDFYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGNDVTREKIIKNVRGYP INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 LNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKTGFGGMASNKGAVAVS INP53_ScerP068_AA_1-1080 LNQY--DDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKKTGFRGMAGNKGAVSIR INP52_ScerP059_AA_1-1109 LNQY--EEKYLLLRVEQMSSLLILFFARSDRAYNIKEVGGSTKKTGFGGITGNKGAVAIR Dd5P3_DdisP050_AA_45-958 LPKVSPNVKYIKLQSSQLVGLLMAIYVREDAIHYFREVQIQNVKCGMNGLAGNKGGIGVR Synaptojanin_MbreP072_AA_56-790 L-----GDDYALLTSVQLVGICLFVLVRTDLVDVVRDVCTCTVKTGAGGKVGNKGAVAVR Synaptojanin_AqueP153_AA_58-806 LSR---DHEYSLLTAEQLVGVCLYIFVRPHLIPFIRDVGVSAVKTGIGGAAGNKGGVAIR unc-26_CeleP194_AA_53-840 LSE---KAPFVLIGSEQLVGVCLFLFARPRVSPYLKDFAVASVKTGMGGATGNKGSVAFR Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 ISR---SHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIR Synaptojanin_NvecP085_AA_53-869 ISR---DFPYVLLTCEQLVGVCLFVFARPHLVPYIRDVAVSTVKTGLGGSAGNKGGVAIR Synaptojanin_SpurP121_AA_48-803 LSR---DHKYVLLVCEQLVGVCLYIFIRPQHAPFIRDVAVDTVKTGLKGAAGNKGGVAIR Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 ISR---DNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIR SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 ------------------------------------------------------------ DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 GAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRRYHNALSKQDKAMSPFTSRKQSWLNNKLK INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 --------------------QLYQK--SCENVTTYLNVDLQMYTFDWINILK-------- INP51_ScerP033_AA_1-946 FKYSATRFCVLVSHLAAGLENVEQR--HNDYKTIAKSIRFSKGLR--IKDHDAIIWMGDF INP53_ScerP068_AA_1-1080 FEYGATSFCFVNSHLAAGATNVEER--RSDYESIVRGITFTRTKM--IPHHDSIFWLGDM INP52_ScerP059_AA_1-1109 FDYGATSFCFVNTHLSAGASNIDER--RNDYNNIYRNITFPRSKT--IPHHDSLFWLGDL Dd5P3_DdisP050_AA_45-958 LLFSDTSFTFVTAHFAAGQSNVEDR--ISDFREIDSTLAFGRQGQFKVSDSDYSFWLGDF Synaptojanin_MbreP072_AA_56-790 LRLYNTPICFICSHLTAGKSHVAER--NQDYHDIYRRIDFGKGRV--LDSHSAVFWFGDF Synaptojanin_AqueP153_AA_58-806 LLLHSTSLCFVCSHLAAHQTKIVER--NQDFAEIHRKVLFPMNQT--ISSHDYVFWCGDL unc-26_CeleP194_AA_53-840 IVVFSTSICFICSHFAAGQNEIRDR--NEDFATTLKKIRFPLGRE--IDSHDVIFWLGDF Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 FQFHSTSFCFICSHLTAGQSQVKER--NEDYKEITQKLCFPMGRN--VFSHDYVFWCGDF Synaptojanin_NvecP085_AA_53-869 LLLHATSICFICSHLAAGQSGVQDR--NNDYLDIATRTAFPMGRT--IRSHDYVFWCGDF Synaptojanin_SpurP121_AA_48-803 FVFHGTSMCFVCAHLAAGQSHIKDR--NDDYAEISSKIMFPMGRS--LESHDYVFWCGDF Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 MLFHTTSLCFVCSHFAAGQSQVKER--NEDFIEIARKLSFPMGRM--LFSHDYVFWCGDF SAC1_MbreP071_AA_26-522 -----------------GQVRVRT------------------------------------ SAC1_ScerP042_AA_2-620 -----------------GGFRPHTA--SIKSPFPDRRPVYIQLIPMIICAALTVLGATIF DDB_G0290653_DdisP053_AA_56-553 -----------------GKYIVEKWSSDLSSTSSSLAESTSITQEYNVLIITDSFILENI F30A10.6_CeleP073_AA_61-513 -----------------GNF---------------------------------------- Sac1_DmelP054_AA_58-502 -----------------GKY---------------------------------------- SAC1_NvecP084_AA_52-521 -----------------GNYVVDANECVSKVCPLQTKRDWR------------------- SACM1L_HsapP109_AA_55-506 -----------------GNYSVDE------------------------------------ SAC1_SpurP120_AA_52-503 -----------------GNYV--------------------------------------- sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 -----------------GLT---------------------------------------- C34B7.2_CeleP032_AA_76-600 -----------------GVFRPRITTMKNLWDLTSDYNLHFPYSL--------------- W09C5.7_CeleP200_AA_52-538 -----------------GQTEADENAEEEENEKEEEE----------------------- FIG4_ScerP064_AA_31-879 MITSSKSLEKAEGRVVETTDLDRDTSPKQELELYEHYLHIISDRSQKLEEKMNSFSYSKY INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 -----------------GKYVP-------------------------------------- CG17840_DmelP052_AA_19-586 -----------------GIYKPSLTKQGPPIWELQTDYDMHNAF---------------- CG7956_DmelP053_AA_49-573 -----------------GQLLRAEDL---------------------------------- FIG4_SpurP118_AA_12-598 -----------------GVFTPREGRPNLWELPTDYYLHHT------------------- FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 -----------------GVFHPTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPE DDB_G0281427_DdisP049_AA_556-710 -----------------GYFVPAKQIAIEKIPLWNLETDHYLHNITNRKQH--------- DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 -----------------GIPV--------------------------------------- INPP5_NvecP083_AA_48-587 -----------------GNPPTEDLSALIDALRSDGQEE--------------------- INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 -----------------GNQEIQEDLTLIDEQ---------------------------- DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 NYRILMSNEDVRRKIVSKE---YASLFEKDQLNQQMIAGESFPYFHEMAIDFPPTYKFDP INP53_ScerP068_AA_1-1080 NYRINLPNEDVRRELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKYDP INP52_ScerP059_AA_1-1109 NYRITLTNDEVRRELRAQKDGYIDRLLQYDQLTQEINEGVVFQGFKEPTLQFRPTYKYDY Dd5P3_DdisP050_AA_45-958 NFRIDLPDEEIRRCVYDQQ---FPKLYNYDQLRKCMEAGRVFNGYREETIAFPPTYKYDL Synaptojanin_MbreP072_AA_56-790 NYRIDLENLECRQACADKD---LATLKEHDQLTRERARLAVFDSFNEPPIHFLPTYKYDF Synaptojanin_AqueP153_AA_58-806 NYRIDLPSSIAKDAISKEE---WDKLVRHDQLTKQKKLGKVFFGFAEGDLTFAPTYKYDQ unc-26_CeleP194_AA_53-840 NYRINLSGDEVKNAVRNGD---YAKLVENDQLTQQKALGQTFVGFNEGQLTFAPTYKYDT Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 NYRIDLTYEEVFYFVKRQD---WKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDV Synaptojanin_NvecP085_AA_53-869 NYRIDMPMDEVKSLIQLKD---WDALAQNDQLNKQRQEHKVFRGYVEGELRFAPTYKYDL Synaptojanin_SpurP121_AA_48-803 NYRIDKDNDEVKDLVAIHD---YEALKECDQLLLERRKGNTFQGFAEGTIRFAPTYKYDL Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 NYRIDLPNEEVKELIRQQN---WDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDL SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 FPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGIQFVNWPKLVDVGFLVVHQTHDKEQQF DDB_G0290653_DdisP053_AA_56-553 SNT--------------------------------------------------------- F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 PIFISHESSEIPPMRKVIGEPLVDIAEDFTDVYDDDDDGDDENDEMTTEALLIAPDHVSV INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 VIK--------------------------------------------------------- DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 GTKNYDTSEKMRIPAWTDRILSRGEVLEQLEYKCCEDILFSDHRPVYAIFRARVTVVDEQ INP53_ScerP068_AA_1-1080 GTGTYDSSEKERTPSWTDRIIYKGENLLPLSYSDAPIMISDHRPVYAAYRAKITFVDDKE INP52_ScerP059_AA_1-1109 GTDNYDTSEKARTPSWTDRIIYKGENLHPLAYSDAPLKISDHKPVYAAYRANVKFVDEKE Dd5P3_DdisP050_AA_45-958 NSTQYDTSQKQRSPAWTDRIVWSNKVHHDLRQLYYHRQEILASDHRPVSSYFQLEVTKID Synaptojanin_MbreP072_AA_56-790 DSDVYDTSEKQRVPSWTDRA---------------------------------------- Synaptojanin_AqueP153_AA_58-806 FSDDYDTSEKCRVPAWCDRILWQRKSFL-------------------------------- unc-26_CeleP194_AA_53-840 FSDDYDTSEKCRAPAWTDRILWKDQRKKGKTQLLSYDRSELKTSDHRPVGAVFKVETFKV Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 GSAAYDTSDKCRTPAWTDRVLWWRKK---------------------------------- Synaptojanin_NvecP085_AA_53-869 FSDDYDTSEKMRIPAWTDRVLWRRRKPRYKSADHVKKHVIKKNERNVSENLLLGDEIVND Synaptojanin_SpurP121_AA_48-803 FSEDYDTSEKMRTPAWTDRILWRR------------------------------------ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 FSDDYDTSEKCRTPAWTDRV---------------------------------------- SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 KGLKYAQSPKFSKPDPL------------------------------------------- DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 DEKFYEKVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDFQ----------- INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 KKTTLGTQIYEKIMERLEGLDDDEKIAVLSDDAFVIESFEGSDSIAGPTHSPTPIPEPKR INP53_ScerP068_AA_1-1080 RLSLKKRLFTEYKQEHPEEPGSLISDLLSLDLDNKSTDGFKSSSESSLLDIDPIMAQPTA INP52_ScerP059_AA_1-1109 KLNLVEKLYAEYKNTHPEALTTGPDELSHARMEKQKESIPLDATVQSAGIKLIDLDDTSS Dd5P3_DdisP050_AA_45-958 KDKERTLRQELYEQKSSQFITTSQSTNNLINTTNQNGKDGANLITKEFEQLTLIKQSAST Synaptojanin_MbreP072_AA_56-790 ------------------------------------------------------------ Synaptojanin_AqueP153_AA_58-806 ------------------------------------------------------------ unc-26_CeleP194_AA_53-840 ------------------------------------------------------------ Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 ------------------------------------------------------------ Synaptojanin_NvecP085_AA_53-869 DAEEEEEDEDDDDDEQESTTE--------------------------------------- Synaptojanin_SpurP121_AA_48-803 ------------------------------------------------------------ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 ------------------------------------------------------------ SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 ------------------------------------------------------------ DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 ------------------------------------------------------------ INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 GRKLPPPSSDLKKWWIGSGKQVKVVLDVDPAVYMINPKRDPNPFVENEDEPLFIER---- INP53_ScerP068_AA_1-1080 SSVASSSPVSSASASLQPVRTQNSSQSRTPIKKPVLRPPPPPAHKSVSAPAPSTSKEKSP INP52_ScerP059_AA_1-1109 CVSPLLSGPSPQPSVVGPGGLSNVSPDKSKLNVLPPPPPTSRHNKEPSSKLLSPTKEISI Dd5P3_DdisP050_AA_45-958 PNL--------------------------------------------------------- Synaptojanin_MbreP072_AA_56-790 ------------------------------------------------------------ Synaptojanin_AqueP153_AA_58-806 ------------------------------------------------------------ unc-26_CeleP194_AA_53-840 ------------------------------------------------------------ Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 ------------------------------------------------------------ Synaptojanin_NvecP085_AA_53-869 ------------------------------------------------------------ Synaptojanin_SpurP121_AA_48-803 ------------------------------------------------------------ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 ------------------------------------------------------------ SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 ------------------------------------------------------------ DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 ------------------------------------------------------------ INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------------------------------ INP51_ScerP033_AA_1-946 ------------------------------------------------------------ INP53_ScerP068_AA_1-1080 TPQTSTASLSSVTKNIQENKPLAQNRRIPPPGFSQNILTPKSTSNLASPMSSKVDLYNSA INP52_ScerP059_AA_1-1109 VSVSPRKGESNLPALERHSTPKPLPPVPALSLSKPVSLQKSSSELQHAKETIDNGKIVPR Dd5P3_DdisP050_AA_45-958 ------------------------------------------------------------ Synaptojanin_MbreP072_AA_56-790 ------------------------------------------------------------ Synaptojanin_AqueP153_AA_58-806 ------------------------------------------------------------ unc-26_CeleP194_AA_53-840 ------------------------------------------------------------ Synj_DmelP055_AA_47-494 ------------------------------------------------------------ SYNJ2_HsapP111_AA_41-810 ------------------------------------------------------------ Synaptojanin_NvecP085_AA_53-869 ------------------------------------------------------------ Synaptojanin_SpurP121_AA_48-803 ------------------------------------------------------------ Synj_DmelP055_AA_664-825 ------------------------------------------------------------ SYNJ1_HsapP110_AA_91-847 ------------------------------------------------------------ SAC1_MbreP071_AA_26-522 ------------------------------------------------------------ SAC1_ScerP042_AA_2-620 ------------------------------------------------------------ DDB_G0290653_DdisP053_AA_56-553 ------------------------------------------------------------ F30A10.6_CeleP073_AA_61-513 ------------------------------------------------------------ Sac1_DmelP054_AA_58-502 ------------------------------------------------------------ SAC1_NvecP084_AA_52-521 ------------------------------------------------------------ SACM1L_HsapP109_AA_55-506 ------------------------------------------------------------ SAC1_SpurP120_AA_52-503 ------------------------------------------------------------ sac1_DdisP054_AA_36-493 ------------------------------------------------------------ DDB_G0274537_DdisP052_AA_574-105 ------------------------------------------------------------ C34B7.2_CeleP032_AA_76-600 ------------------------------------------------------------ W09C5.7_CeleP200_AA_52-538 ------------------------------------------------------------ FIG4_ScerP064_AA_31-879 ------------------------------------------------------------ INPP5_AqueP152_AA_100-699 ------------------------------------------------------------ FIG4_MbreP070_AA_8-476 ------------------------------------------------------------ CG17840_DmelP052_AA_19-586 ------------------------------------------------------------ CG7956_DmelP053_AA_49-573 ------------------------------------------------------------ FIG4_SpurP118_AA_12-598 ------------------------------------------------------------ FIG4_HsapP107_AA_14-424 ------------------------------------------------------------ FIG4_HsapP107_AA_229-641 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_556-710 ------------------------------------------------------------ DDB_G0281427_DdisP049_AA_76-502 ------------------------------------------------------------ INPP5F_HsapP108_AA_49-421 ------------------------------------------------------------ INPP5F_HsapP108_AA_278-570 ------------------------------------------------------------ INPP5_NvecP083_AA_48-587 ------------------------------------------------------------ INPP5_SpurP119_AA_47-407 ------------------------------------------------------------ INPP5_SpurP119_AA_256-568 ------------------------------------------------------------ DDB_G0279397_DdisP051_AA_271-666 ------------------------------------- INP51_ScerP033_AA_1-946 ------------------------------------- INP53_ScerP068_AA_1-1080 SESTRSAQDARQQTPTAFAASRDVNGQPEALLG---- INP52_ScerP059_AA_1-1109 PCPPIRRKSSTAPDEISTSTKNSGVSTTEDPEPAKAS Dd5P3_DdisP050_AA_45-958 ------------------------------------- Synaptojanin_MbreP072_AA_56-790 ------------------------------------- Synaptojanin_AqueP153_AA_58-806 ------------------------------------- unc-26_CeleP194_AA_53-840 ------------------------------------- Synj_DmelP055_AA_47-494 ------------------------------------- SYNJ2_HsapP111_AA_41-810 ------------------------------------- Synaptojanin_NvecP085_AA_53-869 ------------------------------------- Synaptojanin_SpurP121_AA_48-803 ------------------------------------- Synj_DmelP055_AA_664-825 ------------------------------------- SYNJ1_HsapP110_AA_91-847 ------------------------------------- SAC1_MbreP071_AA_26-522 ------------------------------------- SAC1_ScerP042_AA_2-620 ------------------------------------- DDB_G0290653_DdisP053_AA_56-553 ------------------------------------- F30A10.6_CeleP073_AA_61-513 ------------------------------------- Sac1_DmelP054_AA_58-502 ------------------------------------- SAC1_NvecP084_AA_52-521 ------------------------------------- SACM1L_HsapP109_AA_55-506 ------------------------------------- SAC1_SpurP120_AA_52-503 ------------------------------------- sac1_DdisP054_AA_36-493 ------------------------------------- DDB_G0274537_DdisP052_AA_574-105 ------------------------------------- C34B7.2_CeleP032_AA_76-600 ------------------------------------- W09C5.7_CeleP200_AA_52-538 ------------------------------------- FIG4_ScerP064_AA_31-879 ------------------------------------- INPP5_AqueP152_AA_100-699 ------------------------------------- FIG4_MbreP070_AA_8-476 ------------------------------------- CG17840_DmelP052_AA_19-586 ------------------------------------- CG7956_DmelP053_AA_49-573 ------------------------------------- FIG4_SpurP118_AA_12-598 ------------------------------------- FIG4_HsapP107_AA_14-424 ------------------------------------- FIG4_HsapP107_AA_229-641 ------------------------------------- DDB_G0281427_DdisP049_AA_556-710 ------------------------------------- DDB_G0281427_DdisP049_AA_76-502 ------------------------------------- INPP5F_HsapP108_AA_49-421 ------------------------------------- INPP5F_HsapP108_AA_278-570 ------------------------------------- INPP5_NvecP083_AA_48-587 ------------------------------------- INPP5_SpurP119_AA_47-407 ------------------------------------- INPP5_SpurP119_AA_256-568 -------------------------------------