MUSCLE (3.8) multiple sequence alignment C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA -------------------------------------------MNNDAMEHTLGGGILTT CG17840_DmelP052_AA --------------------------------------------------------MNND FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA --------------------------MATSPSLHLSHKSSRVDASNLLSIELDDMGSIDQ W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA ------------------------------------------------------------ SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------------------------------------------------ INPP5F_HsapP108_AA ------------------------------------------------------------ INPP5_SpurP119_AA ------------------------------------------------------------ INPP5_NvecP083_AA ------------------------------------------------------------ INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA ------------------------------------------------------------ INP53_ScerP068_AA ------------------------------------------------------------ INP52_ScerP059_AA ------------------------------------------------------------ Synaptojanin_MbreP072_AA ------------------------------------------------------------ Synaptojanin_AqueP153_AA ------------------------------------------------------------ unc-26_CeleP194_AA ------------------------------------------------------------ SYNJ2_HsapP111_AA ------------------------------------------------------------ Synaptojanin_NvecP085_AA ------------------------------------------------------------ Synj_DmelP055_AA ------------------------------------------------------------ Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA ---------------------------MRKRWACWSGSDAPGGCGGGCGRRRRRSRRKRA DDB_G0281427_DdisP049_AA MSSSISPPPIPTPTPKLNVDNNNKNNNNKHQNKHEENITQDSSSFNKPSFWDDLTYKKQE DDB_G0279397_DdisP051_AA ------------------------------------------------------------ DDB_G0274537_DdisP052_AA ------------------------------------------------------------ C34B7.2_CeleP032_AA --------MPCRLRKITVYETKSRFYIIGCDSTG--SRYNVLK-ID--RIDPKALITGEP FIG4_ScerP064_AA SGSKQRKTSKFVMGKYTLYETKDRMYIVGSNKRE--TMFRILE-IDL-TVPRGELTVLED CG17840_DmelP052_AA NPNIVFNPLISSIQKVVLYETRARLYLVGSNNRE--TRFRLLT-ID--RLAHNRLSIEEN FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA -MPTAAAPIISSVQKLVLYETRARYFLVGSNNAE--TKYRVLK-ID--RTEPKDLVIIDD FIG4_SpurP118_AA ---METDFFISNIQKIVLYETKARFYIIGSNNAE--TEFRVLK-ID--RTEARELLLTDD INPP5_AqueP152_AA QGLLPGGRGESADPNLEVWITKSHVMIMKRGEST----VDTLW-YS--REDGSLLVGSSI W09C5.7_CeleP200_AA ---------------MIIYTTPTALILEEQ--------GERVE-FD--RRNGKVLEKPEE DDB_G0290653_DdisP053_AA --------MNELYYNINLIFLDSYVVLQPDLTIY--KNPKSIF-ID--RTTLKIEQKVYE SAC1_MbreP071_AA ----------MPARHLCRFSSADLLQIDIE--------AGSIV-ID--RHSFEIRSGAAA SAC1_ScerP042_AA ----------MTGPIVYVQNADGIFFKLAEGKGT----NDAVIHLA--NQDQGVRVLGAE sac1_DdisP054_AA -------------MNIELINTNERFILINNGNK-----DKSLN-ID--KHSVKASISVGV F30A10.6_CeleP073_AA ---------MDIYESFNLYSHPEKFFLEPTDLGGGAASKHYLE-ID--RHTNVMKIIDSR Sac1_DmelP054_AA ---MDSREENAVYDDMNLYIAPQSFIIEPNGG------DELLV-IG--RHDKVTRVQPAS SAC1_NvecP084_AA --------MSDDVFFISSHTSPEKFYIEPRDVQS--IGDKILE-ID--RVSQELSLTDNE SACM1L_HsapP109_AA -------MATAAYEQLKLHITPEKFYVEACDDGA----DDVLT-ID--RVSTEVTLAVKK SAC1_SpurP120_AA ---------MAVYETLLLHTQDDKFYIEARDPGT----KEVLV-ID--RLSQEIILEENG CG7956_DmelP053_AA ---------------MEVFQTDSHYIFVKR--------DKSLW-WH--RRTSEFSIKAGW INPP5F_HsapP108_AA ---------------MELFQAKDHYILQQG--------ERALW-CS--RRDGGLQLRPAT INPP5_SpurP119_AA ---------------MELYQAEDNYIIQDK--------DSSLW-CS--RVDGKLVPQPGS INPP5_NvecP083_AA ---------------MELYQARDNFIIKDA--------YFSLW-CN--RSDGGLVPRQGV INP51_ScerP033_AA ----MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQL-----SKTPSVTIKSYP Dd5P3_DdisP050_AA ----------MADNTFRIFITTQSFIIKRDSLHS-----KALV-IN--RRDPSKIDIIQP INP53_ScerP068_AA ---MIIFVSEEPERRLAIVSNLYALVLKPVGKKP----------SD--KPLCAIELLQKN INP52_ScerP059_AA ---MKILLSKQQTRKIAIVSETHGLVFRPINSKN----------SR--RSTCAVELVPKA Synaptojanin_MbreP072_AA ------MGFTRNFRVLEHQRDGSIFLLNRTTGLA-------LW-F---RNDGKFEALTAP Synaptojanin_AqueP153_AA ------MVLNKSIKVSKRWRPKRSVLLESKHIPE-----EAIL-FE--SGSLALLRSSEA unc-26_CeleP194_AA -------MSVRGIRIWRRNDARFQPSILVEKNGL----DGSLL-FQ--GGAIATLDSDST SYNJ2_HsapP111_AA ------MALSKGLRLLGRLGAEGDCSVLLEARGR----DDCLL-FE--AGTVATLAPEEK Synaptojanin_NvecP085_AA -------MIGKSYVCYSSIDQETFSILLECKNRT-----DTLL-FE--SGAIALLSQWET Synj_DmelP055_AA ------MAMSKVIRVLEKSIAPSPHSVLLEHRNK----SDSIL-FE--SHAVALLTQQET Synaptojanin_SpurP121_AA ----MATTMGKSFRVYHKVGPPYSVILEARNKQE------TLL-FE--SDAVAVLSIPET SYNJ1_HsapP110_AA ASEERRMAFSKGFRIYHKLDPPPFSLIVETRHKE-----ECLM-FE--SGAVAVLSSAEK DDB_G0281427_DdisP049_AA SDNYIMPPTCFSLQRFVLYETKTRFYLVGSNRTK--NRFKVLK-ID--RTYEEEVMISED DDB_G0279397_DdisP051_AA ---MNTTQGKISLHDIFETSHGDVFIVSSLSNKK----DTQIIRIE--GRCGMLLFEGLP DDB_G0274537_DdisP052_AA ------MSSFKLSSSANFGGNPRPSITIGNRRITESTSPPTINDFPPSSPPPPLPPKTYK C34B7.2_CeleP032_AA EYDYTREEILELLATISDGSSVVYRSSSKKGTKSGLIERAT--NAFGILGCVRF---VEG FIG4_ScerP064_AA NVFFTRNEIMNVLASLEEATED-------------GLHKKI--TGYGLLGFIKF---TCW CG17840_DmelP052_AA ANEFNSLEIRRFVASLS------------------GSPKVT--SAYGVLGFVRF---LEG FIG4_MbreP070_AA -------------------------------------------MIFVLFQSF-----LKG FIG4_HsapP107_AA RHVYTQQEVRELLGRLDLGNRTKMGQKGSS-----GLFRAV--SAFGVVGFVRF---LEG FIG4_SpurP118_AA KISYTLPQIKDLLQTLRHGNRGASPAPSSSSNPMAGWSRNV--SAFGIAGFVRF---LEG INPP5_AqueP152_AA DVQANS-----------------------------VPTKLC--HSFGLIGKLQL---LSN W09C5.7_CeleP200_AA SLEILDQ----------------------------DVVLCG--NVEFLIGKISF---DEQ DDB_G0290653_DdisP053_AA NSIFTG-----------------------------PIRSCV--KIFGCLGIINL---LSG SAC1_MbreP071_AA KLD--------------------------------SAVDAG--EFYALYGLLRL---LSG SAC1_ScerP042_AA EFP--------------------------------VQGEVV--KIASLMGFIKL---KLN sac1_DdisP054_AA PKNNEK-----------------------------VLTRIE--NVKGIIGCIQL---VSG F30A10.6_CeleP073_AA KQRV-------------------------------PIADTDIKFIYGILGTIKL---VSG Sac1_DmelP054_AA GGLVA------------------------------NLRPTR--RICGVLGTIHL---LSC SAC1_NvecP084_AA GQIP-------------------------------PSADSV--DIFGIMGIIHL---LAG SACM1L_HsapP109_AA DVP--------------------------------PSAVTR--PIFGILGTIHL---VAG SAC1_SpurP120_AA L----------------------------------GIPPGASKPICGIMGIIKL---LRG CG7956_DmelP053_AA DLSSVD-----------------------------DIECIG--VTHGIVGVISL---PNV INPP5F_HsapP108_AA DLLL-------------------------------AWNPICLGLVEGVIGKIQL---HSD INPP5_SpurP119_AA ALGN-------------------------------AWNPVCLGKVFGVIGKLRI---HPE INPP5_NvecP083_AA HPNE-------------------------------AFDPVCKGIVYGVIGKIQF---FPG INP51_ScerP033_AA DTDLSSDS---------------------------NYLEVKSCIFNGLLGLVCL---NGD Dd5P3_DdisP050_AA DQIDQ------------------------------SLRSER--SVYCVLGIFRL---VNE INP53_ScerP068_AA DLKKY------------------------------GFKRLTSHEIFGVIGLIEV---NGL INP52_ScerP059_AA ELNGN------------------------------GFRRLSNHEIYGFIGLIEI---EGL Synaptojanin_MbreP072_AA EYELHGQ----------------------------ELTKRY--DVYGAIGVLELPTEKGS Synaptojanin_AqueP153_AA DLIRK------------------------------EYPDIN--TAYALLGVLQVGQSLS- unc-26_CeleP194_AA DVERR------------------------------SYQKIV--DAYGILGVLAI---TKD SYNJ2_HsapP111_AA EVIKG------------------------------QYGKLT--DAYGCLGELRL---KSG Synaptojanin_NvecP085_AA EAIKK------------------------------NYQKIL--DAYGCLGVLRIN--IDE Synj_DmelP055_AA DVIRK------------------------------QYTKVC--DAYGCLGALQL---NAG Synaptojanin_SpurP121_AA ESLRK------------------------------QYQKMT--DAYGCLGALRL---SVG SYNJ1_HsapP110_AA EAIKG------------------------------TYSKVL--DAYGLLGVLRL---NLG DDB_G0281427_DdisP049_AA PTDYNKQQIQDLLTMIGNANRE-------------GLTRVC--SAYGILGFIRF---LHG DDB_G0279397_DdisP051_AA GVDIFPNHRQAVAYLKKKH----------------TLKSNI--RVFAILGYIIS---EKS DDB_G0274537_DdisP052_AA QEDEDEDEEDEEEEEEEEEEEEEEEEE--------EDDDIN--EEEQINNDIKIRNKINN . C34B7.2_CeleP032_AA Y----YLIIITRAHAVA--T--LGY------HPVYKIVEVAMIPIAMDGV---------- FIG4_ScerP064_AA Y----YLIMVTKYSQVA--V--IGG------HGIYHIDGIDIIPITNNYKKP-------- CG17840_DmelP052_AA Y----YLLLVTKRKCCA--H--IGR------HLVYTIKDTVMVRVNEVTSQR-------- FIG4_MbreP070_AA Y----YLIVVTKRKQVA--S--IGA------HAIYRVEDTIMISLFSKSVAG-------- FIG4_HsapP107_AA Y----YIVLITKRRKMA--D--IGG------HAIYKVEDTNMIYIPNDSVR--------- FIG4_SpurP118_AA Y----YIILITKRKKVA--I--IGG------HTIYKIEDTTMVHIPHDNFR--------- INPP5_AqueP152_AA TGW--YLLIITEAKSIG--R--LPNTD----SDVFCIERVALISLSAEKSIDEIKMETYA W09C5.7_CeleP200_AA H----FLFFVVDSSVVA--C--YRGTSAESSHSIRRIERVIAINVKSDGSVIKSQITPGS DDB_G0290653_DdisP053_AA P----FIICITDFETIG--S--IRET-----QILNRVAKHTITPIARIPISLTE------ SAC1_MbreP071_AA P----YLVLVCGVEAAA--R--ING------HVIYSASDFELMPVASKTTGLVV------ SAC1_ScerP042_AA R----YAIIANTVEETG--R--FNG------HVFYRVLQHSIVSTKFNS----------- sac1_DdisP054_AA H----YLMIFKEHNHVA--T--VTG------KKIYQMKDVELIPFFPNQQSLVSI----- F30A10.6_CeleP073_AA Y----ALIVITKASLIG--Q--VNN------HNIWTIQDAEIIPYKKTTLHLTE------ Sac1_DmelP054_AA D----YLLVATHRLFVG--V--LNG------AVVWRLAGYDIIPYIPNS----------- SAC1_NvecP084_AA P----YLIVITKKKLVG--Y--IQG------SEVWKVLQTNVIPFPRATLHLTE------ SACM1L_HsapP109_AA N----YLIVITKKIKVG--E--FFS------HVVWKATDFDVLSYKKTMLHLTD------ SAC1_SpurP120_AA S----YLVVITKKTKVG--E--ING------QLIWKVAGTETIPYKRTDLHLTE------ CG7956_DmelP053_AA YEP--HLVVVKEASAVG--VL-YPP------HLVYKIKSICILSADDPDTDLPNCTKHTK INPP5F_HsapP108_AA LPW--WLILIRQKALVG--K--LPGD-----HEVCKVTKIAVLSLSEMEPQDLELELCKK INPP5_SpurP119_AA SEW--RLLLIRSHRLVG--Q--LPKG-----HDVYCITRIAVLPLSQNGHPDIEIERCDK INPP5_NvecP083_AA GDW--KLLVITKRTLLG--L--FPGN-----HEVYRVDRVAYLPLSPGDVPELELDPCEK INP51_ScerP033_AA I----YVAVISGVQNVGFPRWKLIDHQVRPSESIYKVLDVDFYSLENDVFDYLLCERSEQ Dd5P3_DdisP050_AA C----YLVVVTESDIAA--NFQFQGQP----NVIRKIRCTDFISFQTGRGHISIGGGGGG INP53_ScerP068_AA L----FVGAITGKSKVA--QP-CPG------ETVNKIFAVDFFCLNDNSWDFIEIDSSGY INP52_ScerP059_AA M----FIATITGKSKVA--QP-IPN------KTVNKIYAVDFFCLNNSKWDFMDIDSSGY Synaptojanin_MbreP072_AA DVTAPVLLVVMDCKSNG--R--LPG------CQVYHISRIDLVYLASAA----------- Synaptojanin_AqueP153_AA -----YIVLVTGCNQVG--R--ISN------TEVYQITSTVMVPL--------------- unc-26_CeleP194_AA EA---VLVAVTGVLSVG--Q--LYG------ADILKITNVEFISLRTF------------ SYNJ2_HsapP111_AA GTSLSFLVLVTGCTSVG--R--IPD------AEIYKITATDFYPL--------------- Synaptojanin_NvecP085_AA EETIHFLILVTGCKSVG--K--VLD------SEIFKITSTQFVPLQVDQ----------- Synj_DmelP055_AA ESTVLFLVLVTGCVSMG--K--IGD------IEIFRITQTTFVSL--------------- Synaptojanin_SpurP121_AA DESLLYLVLVTGCSSVG--K--VQE------SEIFRITSTLFISL--------------- SYNJ1_HsapP110_AA DTMLHYLVLVTGCMSVG--K--IQE------SEVFRVTSTEFISL--------------- DDB_G0281427_DdisP049_AA Y----YIILITKKRKVG--M--IGT------HFIYGIDDITYVYIPPSFPKTNS------ DDB_G0279397_DdisP051_AA S----HLLVATKIRNEG--E--LLGS-----YPINTIIETSWIKIDLSYLSSYQSNEIQT DDB_G0274537_DdisP052_AA R----STLTIAKENIVYIQH--PPPP-----STLNSQLNDDYEEEEEEEEDDDDDNDEEG . C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA QDRREKDVK--------------------------------------------------- W09C5.7_CeleP200_AA GT-----------------------------------------KLKQGTEKIMKFFAEKV DDB_G0290653_DdisP053_AA ------------------------------------------------------------ SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA SNQSTPTHSVSTSNNNNASVPSSGGGSSKSTKLFEGMNKTWGAVKSAGNTIKNTTQQAAN INPP5F_HsapP108_AA HHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESK---------------- INPP5_SpurP119_AA HHFGIRQKANLILGPAEGQQKSLAKTWNSIKSVAQVKKKEVK------------------ INPP5_NvecP083_AA HQSGGRGIKRDTEGQQKSFQQTWKSIKTAATNIKENVKSTSTTKEPKDR----------- INP51_ScerP033_AA N----------------------------------------------------------- Dd5P3_DdisP050_AA GGSGN------------------------------------------------------- INP53_ScerP068_AA PVLPETASTE-------------------------------------------------- INP52_ScerP059_AA PIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSLN------------------------- Synaptojanin_MbreP072_AA ------------------------------------------------------------ Synaptojanin_AqueP153_AA ------------------------------------------------------------ unc-26_CeleP194_AA ------------------------------------------------------------ SYNJ2_HsapP111_AA ------------------------------------------------------------ Synaptojanin_NvecP085_AA ------------------------------------------------------------ Synj_DmelP055_AA ------------------------------------------------------------ Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA ------------------------------------------------------------ DDB_G0281427_DdisP049_AA ------------------------------------------------------------ DDB_G0279397_DdisP051_AA EEGWATTLVDDSNIDSSVSSNSNNNYNNNYNDNNENNNNSSGSSFFSFLSSSSSPSNNNN DDB_G0274537_DdisP052_AA ED---------------------------I------------------------------ C34B7.2_CeleP032_AA -------------STSSEEQKYVKLFQSVD-LSTDFY--FS-------------Y-SYDM FIG4_ScerP064_AA -------------EKSSDEARLLNIFKDLD-LTKTFY--FS-------------Y-TYDI CG17840_DmelP052_AA -------------PPHPHEDRYKRMFQNID-LRSNFY--FS-------------Y-SYDL FIG4_MbreP070_AA -------------PDLPEEERYRRIFHNVD-LTSNFY--FS-------------H-TYDL FIG4_HsapP107_AA -------------VTHPDEARYLRIFQNVD-LSSNFY--FS-------------Y-SYDL FIG4_SpurP118_AA -------------KQHPDEARYLKMFQNVD-LSSNFY--FS-------------Y-SYDL INPP5_AqueP152_AA -------------DIGKLEKKLKEALLQMFNGSRSFY--FS-------------Y-ETDL W09C5.7_CeleP200_AA ---TK--------AEPR-PALLDDVLKLFN-DSKDFY--FC-------------R-SRDV DDB_G0290653_DdisP053_AA -------------EEKKEEKNYLTLLNDLI-ESCDLY--FS-------------Y-NFDV SAC1_MbreP071_AA -------------EQQRAEERCLDLIRTVL-KQRGLY--FS-------------Y-TYDV SAC1_ScerP042_AA -------------RIDSEEAEYIKLLELHL-KNSTFY--FS-------------Y-TYDL sac1_DdisP054_AA -------------PDQDAEEQHLSMIRWLL-SSENFY--FS-------------Y-DYDF F30A10.6_CeleP073_AA -------------KQIRYNRLFTDMLTHVL-SIGGFY--YS-------------T-TLDI Sac1_DmelP054_AA -------------FQRKENENYLRLLRQTL-DTKFFY--FS-------------Y-RYDL SAC1_NvecP084_AA -------------SQQYHNKLYLSMVQSVL-QTESFY--FS-------------C-TYDL SACM1L_HsapP109_AA -------------IQLQDNKTFLAMLNHVL-NVDGFY--FS-------------T-TYDL SAC1_SpurP120_AA -------------EQKEDNKVYESMVQYAL-ENNTYY--FS-------------T-TFDL CG7956_DmelP053_AA LATKQVKSSVGIREPRHIERRITEELHKIFDETDSFY--FS-------------F-DCDI INPP5F_HsapP108_AA -------------EKEKLERRLLEELLKMFMDSESFY--YS-------------L-TYDL INPP5_SpurP119_AA -------------EREKLERRILEELNRMFTESDWFY--YS-------------P-TGDL INPP5_NvecP083_AA -------------ERDKLERRLVEELLKMFNDSDSFY--YS-------------P-TGDI INP51_ScerP033_AA -------------YDKLIHEHPCGPLKKLF-SDGTFY--YS-------------R-DFDI Dd5P3_DdisP050_AA -------------GESKEDDRPYVQVMNLL-NSGHFY--WTPP-----------NSSFDI INP53_ScerP068_AA -------------YQDALPKHPCYELKKLL-SNGSFY--YS-------------S-DFDL INP52_ScerP059_AA -------------AQEQAPKHPCHELRKLL-SNGSFY--YS-------------T-DFDL Synaptojanin_MbreP072_AA -------------HDERPHDYYCTYLKQLF-ATGSFY--FS-------------AREESL Synaptojanin_AqueP153_AA -------------HSNPSVHEGVVAMGKLL-ASGQFY--FS------------------V unc-26_CeleP194_AA -------------GSVENVDSRIIDLQRLL-SSQMFY--FSS------------LQSYDL SYNJ2_HsapP111_AA -------------QEEAKEEERLIALKKIL-SSGVFY--FSWPNDG--------S-RFDL Synaptojanin_NvecP085_AA ------------------DEEGIAEIVKLL-NSGTFY--FA--------TGHGSQPELDL Synj_DmelP055_AA -------------QNAAPNEDKISEVRKLL-NSGTFY--FAHTNASASASGASSY-RFDI Synaptojanin_SpurP121_AA -------------RNNSSDEDRITEVRKLL-NSGTFY--FSWSAST--------TTRFDL SYNJ1_HsapP110_AA -------------RIDSSDEDRISEVRKVL-NSGNFY--FAWSASG--------I-SLDL DDB_G0281427_DdisP049_AA -------------PEFADETRYKGLFLSLD-LTKDFY--FS-------------Y-TYDI DDB_G0279397_DdisP051_AA NNNN---------NNNNSNNNNNNNSNNNN-SNNSGNTNYDSLSSSSGGNSNNNN-NYDS DDB_G0274537_DdisP052_AA ---D---------EDDNENKDKNNDVDSD--ISNKLH--LN-------------SPPLSP C34B7.2_CeleP032_AA SRTFQEN----------------------------SLRSDWNNHGQRRL----------- FIG4_ScerP064_AA TNTLQTN-----------------------ILREKLKAVDRCDITIPCGIT--------- CG17840_DmelP052_AA TRTLQYN---------------------ESAPRYVGAKVDLDRDEPLPDWNTLTSNVDKA FIG4_MbreP070_AA TRPVQSN------------------------MYLPSDLERQRLAEPKPPVL--------- FIG4_HsapP107_AA SHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICS--------- FIG4_SpurP118_AA THSLQHN--------------------------LSAYQNKGEVGNPRVVPI--------- INPP5_AqueP152_AA TQSVQRK-------------------------------HDCGDANKLRKWE--------- W09C5.7_CeleP200_AA TISSQKY------------------------------------FEKREAHT--------- DDB_G0290653_DdisP053_AA TQSEQRA----------------------------SRIESNPLLMIQPLWK--------- SAC1_MbreP071_AA TSPFSQQ---------------------------------SKFTTNRDLYD--------- SAC1_ScerP042_AA TNSLQRN----------------------------------EKVGPAASWK--------- sac1_DdisP054_AA TLTLQRQ-----------------------------YSTTTTTTSGSSLGE--------- F30A10.6_CeleP073_AA SRTFQWL-----------------------------QENAVPLFKTRSMLD--------- Sac1_DmelP054_AA TNSLQRQ-----------------------------REVAQSRPEVSGLLQ--------- SAC1_NvecP084_AA THTLQRL------------------------------SRTSPEFLQMPLYE--------- SACM1L_HsapP109_AA THTLQRL------------------------------SNTSPEFQEMSLLE--------- SAC1_SpurP120_AA THSLQRL------------------------------YNTSPEFLQMPLFE--------- CG7956_DmelP053_AA TNNLQRH-----------------------------------EAKSEESQS--------- INPP5F_HsapP108_AA TNSVQRQ--------------------------------STGERDGRPLWQ--------- INPP5_SpurP119_AA TNSIQRH--------------------------------------HTHKGA--------- INPP5_NvecP083_AA TNTLQRQ-------------------------------CGDHYDHSLPLWK--------- INP51_ScerP033_AA SNIVKNH------------------------------------GLSHNLEY--------- Dd5P3_DdisP050_AA TRTYQSQ--------------------------------CLEPKSDLPVWE--------- INP53_ScerP068_AA TSTLQHR----------------------------------GYGQHSLSTD--------- INP52_ScerP059_AA TCTLQKR----------------------------------GFTEHSLSFD--------- Synaptojanin_MbreP072_AA APGANFT-------------------------------ASARLTVHLPSAC--------- Synaptojanin_AqueP153_AA SVDERQN------------------------------------GGLFSLLS--------- unc-26_CeleP194_AA TRSAQHR----------------------------------------DSHD--------- SYNJ2_HsapP111_AA TVRTQKQ------------------------------------GDDSSEWG--------- Synaptojanin_NvecP085_AA SLSAQQR----------------------------------------YDGH--------- Synj_DmelP055_AA TLCAQRR----------------------------------------QQTQ--------- Synaptojanin_SpurP121_AA SLCAQRQ----------------------------------------KQDH--------- SYNJ1_HsapP110_AA SLNAHRS----------------------------------------MQEQ--------- DDB_G0281427_DdisP049_AA TRTLQYN-----------MTRYFHSPIPKNIPQTNNNSNNNNNNNTNTNTN--------- DDB_G0279397_DdisP051_AA SYGNNNN-------------NNNNNNNNSNNNNNNNNNNNNNNNNNSNNNN--------- DDB_G0274537_DdisP052_AA SQTIYSD---------------SESENENETNKKIDNNNSNNNYNNNNNNN--------- : C34B7.2_CeleP032_AA --------EADER--------FVWNS-FLLEPLR----KNL-------------ISERWF FIG4_ScerP064_AA --------DYNEM--------FVWNN-NLLSPIF----ACI------------DTVFDWF CG17840_DmelP052_AA HERVDYAFRSDSRKR------FVWNA-YLLQPME----GIM--------------LKDWL FIG4_MbreP070_AA --------KPDET--------FLWNH-FLLHPFH----DTL--------------RPEWL FIG4_HsapP107_AA --------EPYMK--------YVWNG-ELLDIIK----STV--------------HRDWL FIG4_SpurP118_AA --------HTKPK--------FAWNH-YLWNRFQ----DQV--------------HPCWA INPP5_AqueP152_AA --------RVDER--------FFWNK-NMLQDLL----DND------------KTIDKWV W09C5.7_CeleP200_AA --------SEDS---------FFWNK-RMVGNLG----EAK-------------ISDKFT DDB_G0290653_DdisP053_AA --------RCDRR--------FFWNY-HLQQIFI----ENS--------------FDSFI SAC1_MbreP071_AA --------IADRR--------FFCNR-LLLEDLLDVPEAQR--HRIGLTLCTRLQAHPLL SAC1_ScerP042_AA --------TADER--------FFWNH-YLTEDLRNFAHQDP-------------RIDSFI sac1_DdisP054_AA --------RCDSR--------FFWNE-KYVTILS----KEH-------------GLGDWI F30A10.6_CeleP073_AA --------RASER--------FIWNG-HLLSQIR----QVP-------------GAERYT Sac1_DmelP054_AA --------RAEQR--------FVWNG-YVLRQFN----CDK--------------MEKFQ SAC1_NvecP084_AA --------RVDPR--------FVWNS-HLLTPFA----VQP-------------ELQRFI SACM1L_HsapP109_AA --------RADQR--------FVWNG-HLLRELS----AQP-------------EVHRFA SAC1_SpurP120_AA --------RADQR--------YVWNG-HMLREFT----AQP-------------ELGKFI CG7956_DmelP053_AA --------QPDER--------FFWNK-HMIRDLI----NLN--------------DKTWI INPP5F_HsapP108_AA --------KVDDR--------FFWNK-YMIQDLTEI--GTP-------------DVDFWI INPP5_SpurP119_AA --------GYDER--------FFWNQ-HMLQDILDT--QNK------------ELARPWI INPP5_NvecP083_AA --------RVDKR--------FFWNS-HMLHDLINN--EDP-------------LASSWI INP51_ScerP033_AA --------TVDNQDLS-----FIWNA-NLASEVI----NWR--SKISNEEKQLFANAGFL Dd5P3_DdisP050_AA --------RVDKR--------FYWNK-YLQKDFI----AYR--------------LYDWC INP53_ScerP068_AA --------TYEEE--------YMWNS-FLMQEMI----TYR--DHLDTNLKQILDDEGFL INP52_ScerP059_AA --------DFDRE--------FMWNS-FLMDEII----TYR--DRLDVTAKELLDQRGFL Synaptojanin_MbreP072_AA --------QRASRSPGERDSSYFWTR-VPWTWVS----RHG------------IASQDWL Synaptojanin_AqueP153_AA --------RSQNRGGTTSQ--FCWNR-SLYVYLQ----RFA------------VNTDRWV unc-26_CeleP194_AA --------CSDAR--------FFWNR-SLHFSFQ----RYG------------IDTDNWL SYNJ2_HsapP111_AA --------NS-----------FFWNQ-LLHVPLR----QHQ------------VSCCDWL Synaptojanin_NvecP085_AA --------SPDNR--------FMWNR-SLHFHVQ----RFG------------INCSEWL Synj_DmelP055_AA --------ETDNR--------FFWNR-MMHIHLM----RFG------------IDCQSWL Synaptojanin_SpurP121_AA --------VSDNR--------FFWNR-SLHLHLQ----RFD------------VNCSDWL SYNJ1_HsapP110_AA --------TTDNR--------FFWNQ-SLHLHLK----HYG------------VNCDDWL DDB_G0281427_DdisP049_AA --------EINKKKLYYNDQ-FTWNH-FLLECLV----DQV-------------KTWYWV DDB_G0279397_DdisP051_AA --------DPTVKQMLKDLQTFPLDGTHFYCELYDLTNYFPSNLNTPHQYCSEFTWNEWM DDB_G0274537_DdisP052_AA --------NNNNNVYT----TYEDEG---IKPTVSIFGSSK------------------- : C34B7.2_CeleP032_AA -------------VEIVHGYVRQEYI---------------------------------- FIG4_ScerP064_AA -------------QCIIHGFIDQVNV---------------------------------- CG17840_DmelP052_AA -------------LEVTHGFVSQSCI---------------------------------- FIG4_MbreP070_AA -------------ISLTHGFVSQSDI---------------------------------- FIG4_HsapP107_AA -------------LYIIHGFCGQSKL---------------------------------- FIG4_SpurP118_AA -------------IHVIHGFVGQCNI---------------------------------- INPP5_AqueP152_AA -------------LPVVQGYIEIKTIPIPSPDQLGIFLKKQQSHDTHVTTFLLGTPPKEG W09C5.7_CeleP200_AA -------------CPIMQGYVATSQL---------------------------------- DDB_G0290653_DdisP053_AA -------------LPVMDGFIKITEC---------------------------------- SAC1_MbreP071_AA -------------VPFAHGFFRSQEL---------------------------------- SAC1_ScerP042_AA -------------QPVIYGYAKTVDA---------------------------------- sac1_DdisP054_AA -------------LPITMGFVESKTL---------------------------------- F30A10.6_CeleP073_AA -------------LPVIHGFIGQNRV---------------------------------- Sac1_DmelP054_AA -------------LPLVLGFVSINQV---------------------------------- SAC1_NvecP084_AA -------------LPVMHGFISITSC---------------------------------- SACM1L_HsapP109_AA -------------LPVLHGFITMHSC---------------------------------- SAC1_SpurP120_AA -------------LPVMVGFISIRIG---------------------------------- CG7956_DmelP053_AA -------------LPIIQGFMQVENC---------------------------------- INPP5F_HsapP108_AA -------------IPMIQGFVQIEEL---------------------------------- INPP5_SpurP119_AA -------------IPIVQGCVQIREC---------------------------------- INPP5_NvecP083_AA -------------LPVIQGYCSIVHC---------------------------------- INP51_ScerP033_AA -------------TFVIRGYCKTALI---------------------------------- Dd5P3_DdisP050_AA -------------FPIIQGFVVSDHL---------------------------------- INP53_ScerP068_AA -------------TTVIRGFAETFVS---------------------------------- INP52_ScerP059_AA -------------TTVIRGFAETIFS---------------------------------- Synaptojanin_MbreP072_AA -------------LPVIRGSVQIRTV---------------------------------- Synaptojanin_AqueP153_AA -------------TPLMCGSVQIQTV---------------------------------- unc-26_CeleP194_AA -------------LKCMAGSVLVRVV---------------------------------- SYNJ2_HsapP111_AA -------------LKIICGVVTIRTV---------------------------------- Synaptojanin_NvecP085_AA -------------FSIMCGGVEIRTV---------------------------------- Synj_DmelP055_AA -------------LQAMCGSVEVRTV---------------------------------- Synaptojanin_SpurP121_AA -------------LKTMCGGVEVRTV---------------------------------- SYNJ1_HsapP110_AA -------------LRLMCGGVEIRTI---------------------------------- DDB_G0281427_DdisP049_AA -------------LPIIHGYFVQDKI---------------------------------- DDB_G0279397_DdisP051_AA RKPFENASLSHLCVVLLQGYASVKSI---------------------------------- DDB_G0274537_DdisP052_AA ---------------VMSSYPPSDSS---------------------------------- . C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA MATASVDVEERGGEEIKRNDRKDEHDIYSSTPLAASLPNELNDTLTQSNQHQLDQSITDT W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA ------------------------------------------------------------ SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------------------------------------------------ INPP5F_HsapP108_AA ------------------------------------------------------------ INPP5_SpurP119_AA ------------------------------------------------------------ INPP5_NvecP083_AA ----------------------------------------------------------HN INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA ------------------------------------------------------------ INP53_ScerP068_AA ------------------------------------------------------------ INP52_ScerP059_AA ------------------------------------------------------------ Synaptojanin_MbreP072_AA ------------------------------------------------------------ Synaptojanin_AqueP153_AA ------------------------------------------------------------ unc-26_CeleP194_AA ------------------------------------------------------------ SYNJ2_HsapP111_AA ------------------------------------------------------------ Synaptojanin_NvecP085_AA ------------------------------------------------------------ Synj_DmelP055_AA ------------------------------------------------------------ Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA ------------------------------------------------------------ DDB_G0281427_DdisP049_AA ------------------------------------------------------------ DDB_G0279397_DdisP051_AA ------------------------------------------------------------ DDB_G0274537_DdisP052_AA ------------------------------------------------------------ C34B7.2_CeleP032_AA ----------------FLPIG-------------------------RISLTIIGRRSTKY FIG4_ScerP064_AA ----------------SVLGK-------------------------SIYITLIARRSHHF CG17840_DmelP052_AA ----------------SIFGR-------------------------HVNVCLVARRSSRF FIG4_MbreP070_AA ----------------NIYGR-------------------------HIYVTLIARRSRHY FIG4_HsapP107_AA ----------------LIYGR-------------------------PVYVTLIARRSSKF FIG4_SpurP118_AA ----------------CVFGR-------------------------PVLMTLVARRSAHY INPP5_AqueP152_AA QSDLISFHTDSKSSQSDLKSSQIDPKSDSESSQAFVMVPNISSDVPTVTMALISRRSRHR W09C5.7_CeleP200_AA ----------------EITDQINA----------------------YLTITIISRRSTRR DDB_G0290653_DdisP053_AA ----------------EINNN-------------------------QFKYIFISRRSCKR SAC1_MbreP071_AA ---------------TSLSGQ-------------------------AYTFALFSRRSLGR SAC1_ScerP042_AA ----------------VLNAT-------------------------PIVLGLITRRSIFR sac1_DdisP054_AA -------------------GG-------------------------TCQFTLISRRNLNR F30A10.6_CeleP073_AA ----------------NVNGK-------------------------EIKLTIISRRSIYR Sac1_DmelP054_AA ----------------QINGQ-------------------------TFFWSIITRRSVQR SAC1_NvecP084_AA ----------------SIKQR-------------------------SFDFILISRRSCFR SACM1L_HsapP109_AA ----------------SINGK-------------------------YFDWILISRRSCFR SAC1_SpurP120_AA ----------------ILNTK-------------------------RFDYILISRRSCLR CG7956_DmelP053_AA ----------------VIGNE-------------------------CFTLALVSRRSRHR INPP5F_HsapP108_AA ----------------VVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHR INPP5_SpurP119_AA ----------------RMTFAPEEGAQSGGSGADSDDSDI------KFNLMLISRRSKFR INPP5_NvecP083_AA MFEEDDMEEQSDIQIGALPPE-------------------------EFDLLLISRRSIFR INP51_ScerP033_AA ----------------EDGPN-------------------------TASITIISRISTES Dd5P3_DdisP050_AA ---------------GHIQGK-------------------------NVVYTLISRRSRFR INP53_ScerP068_AA ----------------YVKKL-------------------------KVALTIISKQSWKR INP52_ScerP059_AA ----------------YINRL-------------------------KVGLTIISRQSWKR Synaptojanin_MbreP072_AA ----------------YAGSE-------------------------QICCLLVSRLSNAR Synaptojanin_AqueP153_AA ----------------YAGDK-------------------------QVKACLISRVSCER unc-26_CeleP194_AA ----------------YVGAN-------------------------TGRVALISRLSCER SYNJ2_HsapP111_AA ----------------YASHK-------------------------QAKACLVSRVSCER Synaptojanin_NvecP085_AA ----------------YAGVS-------------------------QAKACLISRLSCER Synj_DmelP055_AA ----------------YIGAK-------------------------QARAAIISRLSCER Synaptojanin_SpurP121_AA ----------------YCGTR-------------------------QAKACIVSRLSCER SYNJ1_HsapP110_AA ----------------YAAHK-------------------------QAKACLISRLSCER DDB_G0281427_DdisP049_AA ----------------DIFGK-------------------------GLDLILIARRSRYY DDB_G0279397_DdisP051_AA ------------------SNL-------------------------NVSIAYLMKRSKLN DDB_G0274537_DdisP052_AA ----------------------------------------------NL------------ C34B7.2_CeleP032_AA AGTRFLKRGANPTGNVANYVETEQIVWDMASSGNVA-------DGR-FSSFVQMRGS--- FIG4_ScerP064_AA AGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDR-YTSFVQHRGS--- CG17840_DmelP052_AA AGTRFLKRGANFQGDVANEVETEQIVSD---GQ------------R-ICAFTQMRGS--- FIG4_MbreP070_AA AGTRFLKRGCDNAGHCANHVESEQIVHDASEISHRR--------AF-ITSYIQMRGS--- FIG4_HsapP107_AA AGTRFLKRGANCEGDVANEVETEQILCDASVMSFTA--------GS-YSSYVQVRGS--- FIG4_SpurP118_AA AGTRFLKRGANSEGGVANEVETEQIVHEASLSELKR--------GR-FASYVQHRGS--- INPP5_AqueP152_AA AGTRYLRRGVDNEGHVANFVETEMLLLA---AT------------H-LLSFIVVRGS--- W09C5.7_CeleP200_AA AGARYLRRGIDEASNVANFVETELILNI---FE------------H-ELSFVQCRGS--- DDB_G0290653_DdisP053_AA TGARYHIRGADPLGNVANFVETEQIVLF---DQ------------V-LTSFVQVRGS--- SAC1_MbreP071_AA IGTRFHSRGVRISGHCANHVESEQVLVC---GT------------A-ASCFVQVRGS--- SAC1_ScerP042_AA AGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKI---------H-VFSFLQTRGS--- sac1_DdisP054_AA SGTRYNVRGIDKKGNVANNVETEQIIEIK--EN------------T-FTSFVQVRGS--- F30A10.6_CeleP073_AA AGVRFYKRGVDVDGHAANFVETEQIVEYTNPDK------------H-LTSFVQLRGS--- Sac1_DmelP054_AA AGTRLFCRGSDEQGHVANFVETEQIVEF---NG------------Q-LTGFVQTRGS--- SAC1_NvecP084_AA AGVRYFMRGLDGEGNAANYVETEQIIQF---NT------------G-TSSFVQIRGS--- SACM1L_HsapP109_AA AGVRYYVRGIDSEGHAANFVETEQIVHY---NG------------S-KASFVQTRGS--- SAC1_SpurP120_AA AGTRFYMRGLDEQGQAANFVETEQIVQF---NG------------S-RASFVQTRGS--- CG7956_DmelP053_AA AGTRYKRRGVDEKGNCANYVETEQILSF---RH------------H-QLSFTQVRGS--- INPP5F_HsapP108_AA AGMRYKRRGVDKNGNVANYVETEQLIHV---HN------------H-TLSFVQTRGS--- INPP5_SpurP119_AA AGTRYRRRGIDESGACANYVETEQILQT---AE------------H-SVSFVQVRGS--- INPP5_NvecP083_AA AGTRYKRRGVDDDGEVANYVETEQIVRT---EI------------H-SVSFVQVRGS--- INP51_ScerP033_AA KQDTLELEGISEDGRVSLFVETEIVVTT---EK------------F-IFSYTQVNGS--- Dd5P3_DdisP050_AA AGTRFVTRGIDDDGNVANFCESEQILSI---ES------------YGVLAFLQIRGS--- INP53_ScerP068_AA AGTRFNARGVDDEANVANFVETEFIMYS---SQ------------Y-CYAFTQIRGS--- INP52_ScerP059_AA AGTRFNARGIDDDGHVANFVETEMIMYS---SQ------------Y-CYAFTQIRGS--- Synaptojanin_MbreP072_AA SGMRFNTRGVDDEGNAANFVETEQVIFA---GK------------H-ILSFVIARGS--- Synaptojanin_AqueP153_AA AGTRFNVRGLNDEGNVANFVETEQVLSI---DK------------A-IASFVQVRGL--- unc-26_CeleP194_AA VGTRFNVRGANYLGNVANFVETEQLLLF---DE------------K-ECSLLQIRGS--- SYNJ2_HsapP111_AA TGTRFHTRGVNDDGHVSNFVETEQMIYM---DD------------G-VSSFVQIRGS--- Synaptojanin_NvecP085_AA AGTRFYVRGTDDDGHVANFVETEQMIAL---DD------------M-ITSFVQTRGS--- Synj_DmelP055_AA AGTRFNVRGTNDEGYVANFVETEQVIYV---DG------------D-VTSYVQTRGS--- Synaptojanin_SpurP121_AA AGTRFNVRGTNDDGHVANFCETEQVIFL---DN------------K-VTSFIQTRGS--- SYNJ1_HsapP110_AA AGTRFNVRGTNDDGHVANFVETEQVVYL---DD------------S-VSSFIQIRGS--- DDB_G0281427_DdisP049_AA AGARFLKRGINENGQVANDVETEQILQEPLTGWSSK---------AKFSSFVQIRGS--- DDB_G0279397_DdisP051_AA PGTHFYSPGINENASPANEYESELIMWKVQDKQSILINNIASSSNSNLSDLDKKSNSNNN DDB_G0274537_DdisP052_AA --LKVFNNKMGSTDRLTSDLQTDSNSSNNGGSN--------------LFEFEMDSN---- ::: . C34B7.2_CeleP032_AA ---------------------------------------VPMRWSQDP------------ FIG4_ScerP064_AA ---------------------------------------IPLYWTQDA------------ CG17840_DmelP052_AA ---------------------------------------IPSHWSQDI------------ FIG4_MbreP070_AA ---------------------------------------VPVHWEQDH------------ FIG4_HsapP107_AA ---------------------------------------VPLYWSQDI------------ FIG4_SpurP118_AA ---------------------------------------VPALWSQDI------------ INPP5_AqueP152_AA ---------------------------------------VPVYWTQPG------------ W09C5.7_CeleP200_AA ---------------------------------------IPVFWSQRG------------ DDB_G0290653_DdisP053_AA ---------------------------------------IPLIWQQKG------------ SAC1_MbreP071_AA ---------------------------------------IPLCWSQPP------------ SAC1_ScerP042_AA ---------------------------------------VPIYWAEIN------------ sac1_DdisP054_AA ---------------------------------------IPLLWSQFP------------ F30A10.6_CeleP073_AA ---------------------------------------IPLLWTQKP------------ Sac1_DmelP054_AA ---------------------------------------MPFHWHQLP------------ SAC1_NvecP084_AA ---------------------------------------IPLYWTQRP------------ SACM1L_HsapP109_AA ---------------------------------------IPVFWSQRP------------ SAC1_SpurP120_AA ---------------------------------------IPLFWSQRP------------ CG7956_DmelP053_AA ---------------------------------------VPIYWSQPG------------ INPP5F_HsapP108_AA ---------------------------------------VPVFWSQVG------------ INPP5_SpurP119_AA ---------------------------------------VPVFWSQPG------------ INPP5_NvecP083_AA ---------------------------------------VPVFWSQPG------------ INP51_ScerP033_AA ---------------------------------------IPLFWESVE------------ Dd5P3_DdisP050_AA ---------------------------------------VPVFWNQSSPQMSDLKIKMSN INP53_ScerP068_AA ---------------------------------------IPVFWEQGT------------ INP52_ScerP059_AA ---------------------------------------LPIFWEQDT------------ Synaptojanin_MbreP072_AA ---------------------------------------VPIFWSQPG------------ Synaptojanin_AqueP153_AA ---------------------------------------VPVFWDQPG------------ unc-26_CeleP194_AA ---------------------------------------IPLFWEQPG------------ SYNJ2_HsapP111_AA ---------------------------------------VPLFWEQPG------------ Synaptojanin_NvecP085_AA ---------------------------------------VPVFWEQPG------------ Synj_DmelP055_AA ---------------------------------------VPLFWEQPG------------ Synaptojanin_SpurP121_AA ---------------------------------------VPLFWEQPG------------ SYNJ1_HsapP110_AA ---------------------------------------VPLFWEQPG------------ DDB_G0281427_DdisP049_AA ---------------------------------------IPLYWEQDN------------ DDB_G0279397_DdisP051_AA NNNNNNNNNNNNNNNSTSTASTTATATAISSSLSISSTTASLSLSSSS--------TAPN DDB_G0274537_DdisP052_AA ------------------------------------------------------------ C34B7.2_CeleP032_AA -STRGVVGKPLILIDNHE------------------------PHAQTAASHFRDVRNKYG FIG4_ScerP064_AA -S--NLTTKPPIRINVVD------------------------PFFSPAALHFDNLFQRYG CG17840_DmelP052_AA -S--KMVPKPQIQLDICD------------------------PYAQTPSLHFERLLFHYG FIG4_MbreP070_AA ---AGMKAKPPISIARAD------------------------PFASAAAMHFERLFHKFG FIG4_HsapP107_AA -S--TMMPKPPITLDQAD------------------------PFAHVAALHFDQMFQRFG FIG4_SpurP118_AA -T--TMVPKPPINIDMAD------------------------PFAHLAGRHVNDLFSRFG INPP5_AqueP152_AA -----NRYRPLPIIEQTDE-----------------------ETAVAFERHFESQMNLY- W09C5.7_CeleP200_AA -----FKYRPPLIINRSVE-----------------------ETHGVFTEHFKRLKAHYD DDB_G0290653_DdisP053_AA -----KGLKPRPIVENSV------------------------QTDDAFTSHMNELIQLY- SAC1_MbreP071_AA ----DLRYKPPFRMSEYD------------------------DSNLACQRHLSDLCTRF- SAC1_ScerP042_AA ----NLKYKPNLVLGE--------------------------NSLDATKKHFDQQKELY- sac1_DdisP054_AA ----TLKYKPSVKFYGDEK-----------------------ENSQALEQHFKQLHQLY- F30A10.6_CeleP073_AA ----NLRWQPMPTLKPTD------------------------DQLAAFNRAFSWHKQHYG Sac1_DmelP054_AA ----NLRYKPRPVLVPGK------------------------DHLAACGLHFKEQIRLY- SAC1_NvecP084_AA ----NLKYKPKPQVNSSA------------------------DHSLGFQYHIDNEIAHY- SACM1L_HsapP109_AA ----NLKYKPLPQISKVA------------------------NHMDGFQRHFDSQVIIY- SAC1_SpurP120_AA ----NLKYKPVPHISESQ------------------------SHLDAFKRHFDDQVVNY- CG7956_DmelP053_AA -----YKYRPPPRLDRGVA-----------------------ETQQAFELHFTKELETY- INPP5F_HsapP108_AA -----YRYNPRPRLDRSEK-----------------------ETVAYFCAHFEEQLNIY- INPP5_SpurP119_AA -----IKYKPPPRIDRDDD-----------------------ESQEAFKTHFEEDLQRY- INPP5_NvecP083_AA -----YKYRPPPRLDKDEM-----------------------DTQAAFRHHFSHQLSLY- INP51_ScerP033_AA -S--QLLYGKKIKVTKDSI-----------------------EAQGAFDRHFDNLTSKY- Dd5P3_DdisP050_AA LSKIGKISKKKITIARNTQ-----------------------ATTPAFQLHLKEQTKKY- INP53_ScerP068_AA -----SLINPRVQITRSFE-----------------------ATQPVFDKHIMKSVEKY- INP52_ScerP059_AA -----SLISPKIQITRSVE-----------------------ATQPTFDEHFIRLFKKY- Synaptojanin_MbreP072_AA ----LNVGQHKVQLTREFA-----------------------ATQPAFQRHFDQLAAAY- Synaptojanin_AqueP153_AA ----IQTGTNRIRLSRGFH-----------------------CSHAAFVRHFESLLSQY- unc-26_CeleP194_AA ----VNVGSHKVKLRAFE------------------------TSLPAYHRHLSQLQHRY- SYNJ2_HsapP111_AA -L--QVGSHH-LRLHRGLE-----------------------ANAPAFDRHMVLLKEQY- Synaptojanin_NvecP085_AA ----IQVGSHKVKLSRGFE-----------------------AASAAFDRHLTTQKGLY- Synj_DmelP055_AA ----VQVGSHKVKLSRGFE-----------------------TSAAAFDRHMSMMRQRY- Synaptojanin_SpurP121_AA ----INVGVHKVKMSRGFE-----------------------ASAPAFDRHLTMVKAHY- SYNJ1_HsapP110_AA ----LQVGSHRVRMSRGFE-----------------------ANAPAFDRHFRTLKNLY- DDB_G0281427_DdisP049_AA ---NIMTPKPPIKIQRMD------------------------PFLGSTILHFQDLFQRFG DDB_G0279397_DdisP051_AA TITTTSTAIPKVDLNKNNDTDDSNNNNNSNGGLTNNTTNIIPNNNNINEKVIQWTSHVWR DDB_G0274537_DdisP052_AA --------NNNNNNNNNNN-----------------------NNNNNNNNNNNNNVFLNG C34B7.2_CeleP032_AA NPIV-IMNLIKRN--EKRRHEGVLHTQFLKNIEYLNQFLPNEEKLCYISFDVARCNK--- FIG4_ScerP064_AA GGTIQILNLIKTK--EKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASK--- CG17840_DmelP052_AA APLI-MLNLVKKR--ERRKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDMARQSR--- FIG4_MbreP070_AA APII-AFDLVKKK--ERRPRESILLNAYTAALGYLNKFLPKESAIQHVSWDMAKSNK--- FIG4_HsapP107_AA SPII-ILNLVKER--EKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTK--- FIG4_SpurP118_AA SPVI-VVNLVKKR--EKRKRESHLTEALSASLSYLNQFLPPKHQVQYIHLDMARYTK--- INPP5_AqueP152_AA REQV-IVNLI-----NQSGRERIVSTAFEKQLLTLD----CPS-LTYVAFDFHHHCK--- W09C5.7_CeleP200_AA TPLV-AVSLV-----DQRGRELPLAQRFLEHCVKAD-----DNDVTFFSFDLHQHCR--- DDB_G0290653_DdisP053_AA GPTV-IISLI-----DQIGGEASIGDAFESETLLMY----PKEMVKYVAYDFHEKCK--- SAC1_MbreP071_AA GPCL-CINLV-----NKTGSEGILGSRFQDVLQSIE----RALPIKSEWFDFHHECR--- SAC1_ScerP042_AA GDNY-LVNLV-----NQKGHELPVKEGYESVVHALN-----DPKIHYVYFDFHHECR--- sac1_DdisP054_AA GSTT-VVNLI-----DRKGAELKLGEAYEERVKSLK-------DVHYVWFDFHSICK--- F30A10.6_CeleP073_AA GKHV-IVNLV-----NQKGREKKVGGELERISRQAN-----IEFVRYHQFDFHKECH--- Sac1_DmelP054_AA GNNV-AVNLV-----DHKGAEGELEATYARLVREMG-----NPQVRYESFDFHSECR--- SAC1_NvecP084_AA KELV-LINLI-----DQKGPEKVLGDRFSTIIRNS-----PYKETSYEAFDFHKECS--- SACM1L_HsapP109_AA GKQV-IINLI-----NQKGSEKPLEQTFATMVSSLG-----SGMMRYIAFDFHKECK--- SAC1_SpurP120_AA GNQV-LINLI-----DHKGAENRLEKMFAKTVYESG-----NQMMRYEAFDFHHECR--- CG7956_DmelP053_AA GRVC-IVNLV-----EQSGKEKTIGDAYADHVIKLN-----NDRLIYVTFDFHDYCR--- INPP5F_HsapP108_AA KKQV-IINLV-----DQAGREKIIGDAYLKQVLLFN----NSH-LTYVSFDFHEHCR--- INPP5_SpurP119_AA RHVA-IISLI-----EQAGREAIVGSAFMKHVLLYD-----SPKLTYITFDFHEYCR--- INPP5_NvecP083_AA GGVV-VVNLV-----DQTGREKIISDVFMRHILAYN-----CPLLTYITFDFHEYCR--- INP51_ScerP033_AA GVVS-IVNIIK----PKSESQEKLALTYKDCAESKG--------IKITNIEYSSSVL--- Dd5P3_DdisP050_AA GNIV-IVNLLS----KLKSGECDLVNAYEEQIRILR----SPQ-VFYNHFDLNEQTK--- INP53_ScerP068_AA GPVH-VVNLL-----STKSSEIELSKRYKEHLTHSK-KLNFNKDIFLTEFDFHKETS--- INP52_ScerP059_AA GPVH-IINLL-----STKSSEIQLSRRYKEQLKNSE-KMKIGRDVFLTSFDFHRETS--- Synaptojanin_MbreP072_AA GHTV-IVSLL-----GLKGGEYTLESQFEKHASTYD------PDMPFVHFDVHAKCR--- Synaptojanin_AqueP153_AA GPCL-CVDLL-----GNRDMEPLLTEAYVDHLRNLE--EEVPGAAEYVQFDYHGHCR--- unc-26_CeleP194_AA GEFA-IVNLL-----GRKEGERVLGDAFKTQHKSSH----FAPLVDFIDFDYHAQMK--- SYNJ2_HsapP111_AA GQQV-VVNLL-----GSRGGEEVLNRAFKKLLWASC----HAGDTPMINFDFHQFAK--- Synaptojanin_NvecP085_AA GDVC-IVNLL-----GMKEGENALSRIFQDELTESI----HGHDTPMICFDYHRNCK--- Synj_DmelP055_AA GYQT-VVNLLGSSLVGSKEGEAMLSNEFQRHHGMSA-----HKDVPHVVFDYHQECR--- Synaptojanin_SpurP121_AA GDQV-IVNLL-----GSKEGEDMLSKSFQNHLKASS----HDQDTPHILFDYHQMCR--- SYNJ1_HsapP110_AA GKQI-IVNLL-----GSKEGEHMLSKAFQSHLKASE----HAADIQMVNFDYHQMVK--- DDB_G0281427_DdisP049_AA SPII-ILNLVKSN--EKKPRESILRNEFTDCINCLNEMLPEQHRIHYQAWDFHQAAK--- DDB_G0279397_DdisP051_AA RGTVPLWWRAFSKNQGSNEIELFLKDRGKENPNPFEKSESYYQNLLNRYEKFYQENK-DT DDB_G0274537_DdisP052_AA GNNN-NNNNNNNNNNNNNNNNNDINNGGDEVSNEFS----TFEDMSDLHFSNGSSGNINF : : . C34B7.2_CeleP032_AA AANSMPSINVLNVMEDLSMKS-ILK------------NGWFQSFPLSEALKIRPREAFAT FIG4_ScerP064_AA QDGQ----GVIEFLEKYAVNT-VTT------------TGIFHNG---------------- CG17840_DmelP052_AA LSGG----NVMEQLAIHAESI-VQM------------TGMFFKA---------------- FIG4_MbreP070_AA SREP----VVLRILDQYAQHF-LKQ------------QGIFTSR---------------- FIG4_HsapP107_AA SKLC----NVLDRLNVIAESV-VKK------------TGFFVNRPDSYCSILRPDEKWNE FIG4_SpurP118_AA NKNA----DVMSKLEKIASRS-VEK------------TGIFLSG-HAIHPSIPVREGART INPP5_AqueP152_AA VNQW----HNINLLLSNIEQY-ITR------------QKYFWID---------------- W09C5.7_CeleP200_AA GLNF----QKLQTLISSMEET-LKT------------IGFCWVD---------------- DDB_G0290653_DdisP053_AA NNRY----DRLSELLNSVKPL-VDQ------------YGYLFKS---------------- SAC1_MbreP071_AA NMQW----QHLAKLKASTSNW-RQH------------QGISTMS---------------- SAC1_ScerP042_AA KMQW----HRVKLLIDHLEKLGLSN------------EDFFHKV---------------- sac1_DdisP054_AA GMRY----DKLSILMDQLKDD-LKQ------------YGFFFVE---------------- F30A10.6_CeleP073_AA SMQW----HRIDLLREQLSQE-ISS------------FGYFYLS---------------- Sac1_DmelP054_AA KMRW----DRLNILIDRLAHE-QDQ------------FGVYHVF---------------- SAC1_NvecP084_AA KMRW----DRLNLLIDRLSPD-QKK------------FGYFSMG---------------- SACM1L_HsapP109_AA NMRW----DRLSILLDQVAEM-QDE------------LSYFLVD---------------- SAC1_SpurP120_AA KMRW----DRLSILMDKLAKD-QQQ------------FGYFWMD---------------- CG7956_DmelP053_AA GMRF----ENVSALIDAVGPE-AGA------------MGFHWRD---------------- INPP5F_HsapP108_AA GMKF----ENVQTLTDAIYDI-ILD------------MKWCWVD---------------- INPP5_SpurP119_AA GLRF----DKVSVLLESIRDV-IKE------------MRYCWAD---------------- INPP5_NvecP083_AA GMKF----ENVSVLVDSIGDV-IKD------------MRYCWTD---------------- INP51_ScerP033_AA TKSP----HKLLYLLKQDIYE----------------FGAFAYD---------------- Dd5P3_DdisP050_AA GNRM----DPLDSLINYIDNQSISGGGGTTGGVSEKIVGYFFQN---------------- INP53_ScerP068_AA QEGF----SGVRKLIPLILDS-LLS------------SGYYSYD---------------- INP52_ScerP059_AA QDGF----AAASRIIPKIRNT-ILD------------AGYFSYD---------------- Synaptojanin_MbreP072_AA GNKKA---VKMLPLVKQLRTW-LTS------------DSFFSLT---------------- Synaptojanin_AqueP153_AA PKHN----EALETILLPMCSRFIDT------------CSYYLET---------------- unc-26_CeleP194_AA ISK-----EAIVQLKKKMSPH-MTK------------HGFFYSM---------------- SYNJ2_HsapP111_AA GGKL----EKLETLLRPQLKLHWED------------FDVFTKG---------------- Synaptojanin_NvecP085_AA GGRT----SKLKDFADKARQL-FNS------------NSLFFSK---------------- Synj_DmelP055_AA GGNF----SALAKLKERIVAC-GAN------------YGVFHAS---------------- Synaptojanin_SpurP121_AA GKV-----DNLPLLKKKVATE-MDQ------------FGFFFSE---------------- SYNJ1_HsapP110_AA GGKA----EKLHSVLKPQVQK-FLD------------YGFFYFN---------------- DDB_G0281427_DdisP049_AA SKDE----DHMAWLDSFANQS-ILK------------TGIFYSSSKLYCNFLRENYNSSS DDB_G0279397_DdisP051_AA NLAGIPTIQLINLLKQENDKQEVIL------------SQLYQKS-------------CEN DDB_G0274537_DdisP052_AA GGSFSMDGNTRASMSGSGGLKSSQK------------FDFKVKY---------------- . C34B7.2_CeleP032_AA LDAHHSKD--------------------------GRFMI-Q-HGICRTNCVDCLDRTNVA FIG4_ScerP064_AA ------PD--------------------------FASTKIQ-EGICRSNCIDCLDRTNAA CG17840_DmelP052_AA ------AG--------------------------SEPGL-Q-TGIVRTNCVDCLDRTNSA FIG4_MbreP070_AA QRLSLVAE--------------------------ADAGLDSGHGVVRVNCVDCLDRTNTA FIG4_HsapP107_AA L---GGCV--------------------------IPTGRLQ-TGILRTNCVDCLDRTNTA FIG4_SpurP118_AA DIPQEGSC--------------------------EQVFIRQ-MGVVRTNCVDCLDRTNTA INPP5_AqueP152_AA --NDEGSS--------------------------GQPLCYQ-NGVFRVNCMDCLDRTNVV W09C5.7_CeleP200_AA ------KT--------------------------GEVVQSQ-KGVVRTNCIDCLDRTNLV DDB_G0290653_DdisP053_AA ----TMIG--------------------------IEPTIQQ-SGCFRTNCIDCLDRTNVV SAC1_MbreP071_AA -----LTS--------------------------GRLAHRQ-KGVIRTNCIDVLDRTNVV SAC1_ScerP042_AA -IDSNGNT--------------------------VEIVNEQ-HSVVRTNCMDCLDRTNVV sac1_DdisP054_AA -------D--------------------------GKIVQKQ-QGVFRTNCIDNLDRTNVV F30A10.6_CeleP073_AA -----PNS--------------------------METSRFQ-RGFFRTNCMDCLDRTNVV Sac1_DmelP054_AA ------DD--------------------------GKLVSTQ-TGVFRTNCIDCLDRTNVV SAC1_NvecP084_AA ------KD--------------------------KDIQSEQ-KGVFRTNCIDSLDRTNVV SACM1L_HsapP109_AA ------SA--------------------------GQVVANQ-EGVFRSNCMDCLDRTNVI SAC1_SpurP120_AA ------AN--------------------------NELLKHQ-VGVFRTNCMDCLDRTNVV CG7956_DmelP053_AA -------Q--------------------------RGMICNQ-KSVFRVNCMDCLDRTNVV INPP5F_HsapP108_AA -------E--------------------------AGVICKQ-EGIFRVNCMDCLDRTNVV INPP5_SpurP119_AA -------A--------------------------EGVILEQ-RGVFRVNCMDCLDRTNVV INPP5_NvecP083_AA -------P--------------------------KGIICEQ-RSVFRVNCMDCLDRTNVV INP51_ScerP033_AA -----ISR--------------------------GIYFAKQ-TGVLRISAFDSIEKPNTV Dd5P3_DdisP050_AA ------SN--------------------------GQIISKQ-NGIIRTNCKDCLDRTNIV INP53_ScerP068_AA -----VRE--------------------------KKNISEQ-HGIFRTNCLDCLDRTNLA INP52_ScerP059_AA -----VKE--------------------------GRLISEQ-DGVFRTNCLDCLDRTNLI Synaptojanin_MbreP072_AA -------G--------------------------KRVNHEQ-LGIIRVNCLDCLDRTNLC Synaptojanin_AqueP153_AA -------D--------------------------GEVVSAQ-TGVLRVNCLDCLDRSNNS unc-26_CeleP194_AA -------G--------------------------KEIVKRQ-TGVIRTNCLDCLDRTNAV SYNJ2_HsapP111_AA -------E--------------------------NVSPRFQ-KGTLRMNCLDCLDRTNTV Synaptojanin_NvecP085_AA -------G--------------------------GKLEKRQ-KGVMRSNCLDCIDRTNNM Synj_DmelP055_AA -------N--------------------------GQVLREQ-FGVVRTNCLDCLDRTNCV Synaptojanin_SpurP121_AA -------G--------------------------GEVIRQQ-TGTIRSNCLDCLDRTNAV SYNJ1_HsapP110_AA -------G--------------------------SEVQRCQ-SGTVRTNCLDCLDRTNSV DDB_G0281427_DdisP049_AA DDNGGSTTTTTTTTAATTISGLNEKENELFSYLFNEIGTEQ-IGVVRTNCIDSLDRTNAA DDB_G0279397_DdisP051_AA VTTYLNVD--------------------------LQMYTFDWINILKANN-NSLSKTVQN DDB_G0274537_DdisP052_AA ----------------------------------HELYRVM--SIYQLKDKIVVKPANSV . . . :. . C34B7.2_CeleP032_AA QFVIAKVALGCQLCAMGILDE---PNLTLQ----------SEVCRLLEDMFDEHGDTMAL FIG4_ScerP064_AA QFVIGKRALGCQLKSLGIIDN---SYLEYD----------SDIVNILTELFHDLGDTIAL CG17840_DmelP052_AA QFAIGKCALGHQLERLGFVKS---AKLEFD----------SDCVTMLENLYEEHGDTLAL FIG4_MbreP070_AA QFMIGLCALRHQLFELGVIADTQASQIPPD----------SPVNRVLEEMYEDHGDTIAL FIG4_HsapP107_AA QFMVGKCALAYQLYSLGLIDK---PNLQFD----------TDAVRLFEELYEDHGDTLSL FIG4_SpurP118_AA QFVTGKYALGHQLYSLGVVAD---PELEFD----------SDVVRMLEDLYEDMGDTLAL INPP5_AqueP152_AA QSVICKEFIQTALQKLGLID----PFTSLT----------GQFLRHYQELWANNGDTISR W09C5.7_CeleP200_AA QGQISLFVVLQQAQRLGIFG----PLCEPP----------EVLVQTMQTMWADNGDVIST DDB_G0290653_DdisP053_AA QSVLAHYILHSQLTRMGIIG----ANERIEDH--------QQFETQFKNIWADNADVMSE SAC1_MbreP071_AA QTMFAQDALLLQLQHLAEFL----NLAPTTATESALATSWPGLLTTFRGTWADHADEISI SAC1_ScerP042_AA QSVLAQWVLQKEFESADVVA----TGSTWEDN--------APLLTSYQNLWADNADAVSV sac1_DdisP054_AA QSLITRHSLENQMASVLNKQI---PSTTFKG---------DQFEYVFKNIWADHGDAIST F30A10.6_CeleP073_AA QSMLARESLTEQLRMLGILY----SEQKVQDI--------PLLEDAFKQMWADNGDECSR Sac1_DmelP054_AA QSMLARRSLTAVLQKLGVLH----VGQKVEHAS-------DIFESIFKGVWADNADLVSL SAC1_NvecP084_AA QSMLARNSLQLQLEEYGVLA----TGERIVDH--------NDFEYTFKNVWADNADACSV SACM1L_HsapP109_AA QSLLARRSLQAQLQRLGVLH----VGQKLEEQ--------DEFEKIYKNAWADNANACAK SAC1_SpurP120_AA QSMLARRALQDQMQQMGILK----QGENLDDHYT------AAFESTFKNTWADNADACSK CG7956_DmelP053_AA QTAIGKAVLESQLVKLGLSP----PYTPIP----------EQLKSPFMVLWANNGDIISR INPP5F_HsapP108_AA QAAIARVVMEQQLKKLGVMP----PEQPLP----------VKCNRIYQIMWANNGDSISR INPP5_SpurP119_AA QTALARVVLRTQLRKLGLLL----PEQRLV----------PSIKTIYQDMWANNGDIVSR INPP5_NvecP083_AA QAALARHLLEMQLRKLGKLM----PDQTLP----------ASIRAPFKEMWANNGDAISR INP51_ScerP033_AA ERLVSKEVLELTTNEIDVFE--------LT----------SPFLDAHDKLWSENYYWLDR Dd5P3_DdisP050_AA QSRVSWVLFESQLRKLGLFR----GHDSIGSY--------PRVSQTLKTTWADNGDALSI INP53_ScerP068_AA QQIISLAAFRTFLEDFRLIS----SNSFIDD---------DDFVSKHNTLWADHGDQISQ INP52_ScerP059_AA QQTISLAVFKLFLEDFRLVK----PSSFIDD---------NEFVQKVNALWADNGDQISQ Synaptojanin_MbreP072_AA QSVVGLAVLEDMLGTLK-------SELDLRESKL------LEFRRVFALMWSVNGDNVSR Synaptojanin_AqueP153_AA QAMFGQQLLVQQLDGLKLSS----KVNVL-----------SRFKQIFERFWMQNGDNISK unc-26_CeleP194_AA QTAIGLQMSHDQVAFLNLNA----GKVNVE----------QRVEEILRDLWQKNGDQCST SYNJ2_HsapP111_AA QSFIALEVLHLQLKTLGL------SSKPIV----------DRFVESFKAMWSLNGHSLSK Synaptojanin_NvecP085_AA QTFIGLEMLLVQLQCLGLGS----KASLV-----------PRFQEAFTSMWSQNGDHISR Synj_DmelP055_AA QTYLGLDTLGIQLEALKMGG----KQQNI-----------SRFEEIFRQMWINNGNEVSK Synaptojanin_SpurP121_AA QTFFGQDMLAKQLEALGVSS----KPQIM-----------SRFLETYKTIWGLSGDHISR SYNJ1_HsapP110_AA QAFLGLEMLAKQLEALGLAE----KPQLV-----------TRFQEVFRSMWSVNGDSISK DDB_G0281427_DdisP049_AA QFCIGKCALGYQLYSMGLLDS---PSLDFN----------TGIVQVLIDMYEACGNQIAL DDB_G0279397_DdisP051_AA LWDSTKSSIDSVGFSNGLIK----PFDNNQL---------INLNLNLNLNLNLNLNLNNN DDB_G0274537_DdisP052_AA NTSTNSNIESLVIDRSTFKI----TSQYYS----------TEYLINNSSDFKKKSSGHHH C34B7.2_CeleP032_AA QYAGSQLVHSIKTYKKTAAFQERRRDVFQTLSR--------------------------- FIG4_ScerP064_AA QYGGSHLVNTMETYRKINQWSSHSRDMIESIKR--------------------------- CG17840_DmelP052_AA QYGGSQLVHRIKTYRKTAPWGSQGSDVMQTLSR--------------------------- FIG4_MbreP070_AA QYGGSQLVNRIQSYRKTRPWTSNSRDILNTVAR--------------------------- FIG4_HsapP107_AA QYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSR--------------------------- FIG4_SpurP118_AA QYGGSQLVHSISTYRKIAPWTSHSRDIKQTLSR--------------------------- INPP5_AqueP152_AA QYTGTDAMKGDLTRYGQRRLYGVMKDGYNSAHR--------------------------- W09C5.7_CeleP200_AA QYAGTAALKGDVTRNGERKLMGVMKDGYNSASR--------------------------- DDB_G0290653_DdisP053_AA QYTGTVALKTDFTRTGKRSVKGTMTDGVNSVRR--------------------------- SAC1_MbreP071_AA QYAGTPAQKSDFTRTGKRTLRGTLRDLYHSALR--------------------------- SAC1_ScerP042_AA AYSGTGALKTDFTRTGKRTRLGAFNDFLNSASR--------------------------- sac1_DdisP054_AA QYSGTGALKNDFTRTGKRNFQGVLRDGENSVKR--------------------------- F30A10.6_CeleP073_AA QYAGTGALKADFTRHGRRTYVGAMKDGVNAVSR--------------------------- Sac1_DmelP054_AA QYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMR--------------------------- SAC1_NvecP084_AA QYAGTGALKTDFTR--QEVLFGAMRDGVNSIVT--------------------------- SACM1L_HsapP109_AA QYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIR--------------------------- SAC1_SpurP120_AA QYAGTGALKTDFTRTGKRTKFGLLKDGMNSLIR--------------------------- CG7956_DmelP053_AA QYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIIDLMQGQLLRAED INPP5F_HsapP108_AA QYAGTAALKGDFTRTGERKLAGVMKDGVNSANR--------------------------- INPP5_SpurP119_AA QYAGTAALKGDYTRTGERKLTGLMKDGYNSASR--------------------------- INPP5_NvecP083_AA QYAGTAALKGDFTRTGERKFTGLMKDGYNSANR--------------------------- INP51_ScerP033_AA TYTKHTKNSGKYTK---------------------------------------------- Dd5P3_DdisP050_AA QYAGSGSLKSTLTREGDYGIMGMLADGKKTMTR--------------------------- INP53_ScerP068_AA IYTGTNALKSSFSRKGKMSLAGALSDATKSVSR--------------------------- INP52_ScerP059_AA IYTGTNALKSSYSRKGKMSFSGALSDATKSVSR--------------------------- Synaptojanin_MbreP072_AA CVTGTGAIS------GGVK-TSKLKDMQRSVVR--------------------------- Synaptojanin_AqueP153_AA LYAGTRAL-------GSSSKVSKLRNSARSVQR--------------------------- unc-26_CeleP194_AA IYAGTGALD------GKS----KLKDASRSLAR--------------------------- SYNJ2_HsapP111_AA VFTGSRALE------GKAK-VGKLKDGARSMSR--------------------------- Synaptojanin_NvecP085_AA IYIGTGALD------GKARVASKLRDGARSVKR--------------------------- Synj_DmelP055_AA IYAGTGAIQ------GGS----KLMDGARSAAR--------------------------- Synaptojanin_SpurP121_AA IYAGTGALE------GKTK-AGKLRDGARSVTR--------------------------- SYNJ1_HsapP110_AA IYAGTGALE------GKA----KLKDGARSVTR--------------------------- DDB_G0281427_DdisP049_AA QYGGSELANTIKTY-TKHSLSSQSRDLVNAIKR--------------------------- DDB_G0279397_DdisP051_AA NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN--------------------------- DDB_G0274537_DdisP052_AA HHHSSNGEVSL-----NSSVDFSIRSNSSSNIN--------------------------- C34B7.2_CeleP032_AA ---------------------------------------------YYSNTFNDWDKQMA- FIG4_ScerP064_AA ---------------------------------------------FYSNSFVDAQRQDA- CG17840_DmelP052_AA ---------------------------------------------YYSNTFSDTEKQHS- FIG4_MbreP070_AA ---------------------------------------------YYSNSFTDADKQMA- FIG4_HsapP107_AA ---------------------------------------------YYSNAFSDADRQDS- FIG4_SpurP118_AA ---------------------------------------------YYSNAFSDNDKQSA- INPP5_AqueP152_AA ---------------------------------------------YLQSLFRDAYRQVV- W09C5.7_CeleP200_AA ---------------------------------------------YYLTHTKDAQRQKA- DDB_G0290653_DdisP053_AA ---------------------------------------------YINKNFKDDEKQSA- SAC1_MbreP071_AA ---------------------------------------------YFHNNFLDGGKQDA- SAC1_ScerP042_AA ---------------------------------------------YYQNNWTDGPRQDS- sac1_DdisP054_AA ---------------------------------------------YYLNNFKDGFRQDS- F30A10.6_CeleP073_AA ---------------------------------------------YVRNNFGDGYRQDS- Sac1_DmelP054_AA ---------------------------------------------YYLNNFADGQRQDS- SAC1_NvecP084_AA ---------------------------------------------CFIHIFF--SMQDS- SACM1L_HsapP109_AA ---------------------------------------------YYKNNFSDGFRQDS- SAC1_SpurP120_AA ---------------------------------------------YYMNNFVDGFRQDS- CG7956_DmelP053_AA LQEDEVLSTILQILTPETRPPLHGYYNPGVLGPELQLLESIVTTSYYLARFKDSYRQAT- INPP5F_HsapP108_AA ---------------------------------------------YYLNRFKDAYRQAV- INPP5_SpurP119_AA ---------------------------------------------YVQNQLKDAFRQVA- INPP5_NvecP083_AA ---------------------------------------------YYLNRFKAAYRQTL- INP51_ScerP033_AA ---------------------------------------------VYSKLFGSRVRLYDP Dd5P3_DdisP050_AA ---------------------------------------------FYINNFKDPGRQDV- INP53_ScerP068_AA ---------------------------------------------IYINNFMDKEKQQN- INP52_ScerP059_AA ---------------------------------------------MYINNFVDKGKQQN- Synaptojanin_MbreP072_AA ---------------------------------------------TFKNNFMDSRRQAA- Synaptojanin_AqueP153_AA ---------------------------------------------TIVNNFMDSSKQEA- unc-26_CeleP194_AA ---------------------------------------------TIQNNLMDGAKQES- SYNJ2_HsapP111_AA ---------------------------------------------TIQSNFFDGVKQEA- Synaptojanin_NvecP085_AA ---------------------------------------------TIRSNFLDGSKQEA- Synj_DmelP055_AA ---------------------------------------------TIQNNLLDNSKQEA- Synaptojanin_SpurP121_AA ---------------------------------------------TIQNNFFDGTKQES- SYNJ1_HsapP110_AA ---------------------------------------------TIQNNFFDSSKQEA- DDB_G0281427_DdisP049_AA ---------------------------------------------YISNSFIDADKQHS- DDB_G0279397_DdisP051_AA --------------------------------------------------NNNNNNNNSV DDB_G0274537_DdisP052_AA ---------------------------------------------SFNHKELNNGLNNSK C34B7.2_CeleP032_AA -------------------------------------------------INLFL-GVFRP FIG4_ScerP064_AA -------------------------------------------------INLFL-GHYSW CG17840_DmelP052_AA -------------------------------------------------INLFL-GIYKP FIG4_MbreP070_AA -------------------------------------------------INLFL-GKYVP FIG4_HsapP107_AA -------------------------------------------------INLFL-GVFHP FIG4_SpurP118_AA -------------------------------------------------INLFL-GVFTP INPP5_AqueP152_AA -------------------------------------------------IDLQQ-GAPVQ W09C5.7_CeleP200_AA -------------------------------------------------INIVT-GQTEA DDB_G0290653_DdisP053_AA -------------------------------------------------IDLFL-GKYIV SAC1_MbreP071_AA -------------------------------------------------LLLLT-GQVRV SAC1_ScerP042_AA -------------------------------------------------YDLFL-GGFRP sac1_DdisP054_AA -------------------------------------------------YFLFT------ F30A10.6_CeleP073_AA -------------------------------------------------IDLFL-GNFLV Sac1_DmelP054_AA -------------------------------------------------IDLFL-GKYLV SAC1_NvecP084_AA -------------------------------------------------IDLFL-GNYVV SACM1L_HsapP109_AA -------------------------------------------------IDLFL-GNYSV SAC1_SpurP120_AA -------------------------------------------------TDLLL-GNYVV CG7956_DmelP053_AA -------------------------------------------------IDLML-GNQVS INPP5F_HsapP108_AA -------------------------------------------------IDLMQ-GIPVT INPP5_SpurP119_AA -------------------------------------------------IDLML-GNQEI INPP5_NvecP083_AA -------------------------------------------------IDMML-GNPPT INP51_ScerP033_AA -------------------------------------------------LHIYI-SQYLK Dd5P3_DdisP050_AA -------------------------------------------------LDLLL-GLHKS INP53_ScerP068_AA -------------------------------------------------IDTLL-GRLPY INP52_ScerP059_AA -------------------------------------------------IDTLL-GKLPH Synaptojanin_MbreP072_AA -------------------------------------------------IDLLL-GTYRD Synaptojanin_AqueP153_AA -------------------------------------------------IDLLLLNGYVG unc-26_CeleP194_AA -------------------------------------------------FDLFLTGAAYD SYNJ2_HsapP111_AA -------------------------------------------------IKLLLVGDVYG Synaptojanin_NvecP085_AA -------------------------------------------------IDLLLLGNTFV Synj_DmelP055_AA -------------------------------------------------IDVLLVGSTLS Synaptojanin_SpurP121_AA -------------------------------------------------IDVLLLGSSLV SYNJ1_HsapP110_AA -------------------------------------------------IDVLLLGNTLN DDB_G0281427_DdisP049_AA -------------------------------------------------INLFL-GYFVP DDB_G0279397_DdisP051_AA GGVGGNNNNSQQINNITSPSPSLSSSSFLPMI-----------------SSPFIKNNITP DDB_G0274537_DdisP052_AA EGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSSSSSLHQQSILAYGIVGIINLLS-GPYLI C34B7.2_CeleP032_AA RIT-----------------------------------------TMKNLWDLTS------ FIG4_ScerP064_AA RE------------------------------------------GFPSLWEMNT------ CG17840_DmelP052_AA SLT----------------------------------------KQGPPIWELQT------ FIG4_MbreP070_AA LKE--------------------------------------------------------- FIG4_HsapP107_AA TE------------------------------------------GKPHLWELPT------ FIG4_SpurP118_AA RE------------------------------------------GRPNLWELPT------ INPP5_AqueP152_AA DALTTLSQSQKGISEDEQ-------------------GLRQRSYSDLPPWSSEREQLIAD W09C5.7_CeleP200_AA DENAE--------------------------------EEENEKEEEENISRMVT------ DDB_G0290653_DdisP053_AA EKWSSDLSSTSSSLAESTSITQEYNV-----------LIITDSFILENISNTNTSSSSSS SAC1_MbreP071_AA RTS-----------------------------------------NVETIAKALKG----- SAC1_ScerP042_AA HTA-----------------------------------------SIKSPFPDRR------ sac1_DdisP054_AA -------------------------------------NPSVDLTTAKQHESKPP------ F30A10.6_CeleP073_AA DSS--------------------------------------------------------- Sac1_DmelP054_AA NDN--------------------------------------EGGAVPSPLESKH------ SAC1_NvecP084_AA DAN--------------------------------------ECVSKVCPLQTKR------ SACM1L_HsapP109_AA DEL-----------------------------------------ESHSPLSVPR------ SAC1_SpurP120_AA EEG--------------------------------------EGVTRPSPIRKSK------ CG7956_DmelP053_AA SESLSALGGQAGP------------------------DENDGTENAEQAKLLVE------ INPP5F_HsapP108_AA EDLYSIFTKEKEHEAL---------------------HKENQRSHQELISQLLQ------ INPP5_SpurP119_AA QEDLTLIDEQKASAEMG--------------------KDVWDGVDEEDIKQRIQ------ INPP5_NvecP083_AA EDLSALI------------------------------DALRSDGQEEEQWTMEREDPEGE INP51_ScerP033_AA QLR-----------------------------------------SKYTFEKDIS-IFAGT Dd5P3_DdisP050_AA MVVNNSNNGNGGNGGNGSGHDDNIR------------KQVQDRVKEYSKKEWRN-VFVGT INP53_ScerP068_AA QKAVQLYDPVNEYVS----------------------TKLQSMSDKFTSTSNIN-LLIGS INP52_ScerP059_AA QQVVELYDPICEYVN----------------------ERLLESEEKFTTHSNIN-LFVGT Synaptojanin_MbreP072_AA GQADELVIPNVLMRQRLD-------------------EAMRLRINDYSDVMPINGL---- Synaptojanin_AqueP153_AA EIGIQTRNLLKPADLLASLPLR---------------KSLTERWQEYTSTEKLR-VCVGT unc-26_CeleP194_AA PRLFDRACNILPPSLIQESYYYHEYADAV--------SQLVERSPEIAEPQSIK-IFVGT SYNJ2_HsapP111_AA EEVADKGGMLLDSTALLVTPRIL--------------KAMTERQSEFTNFKRIR-IAMGT Synaptojanin_NvecP085_AA GELGERARALLYSSFLHSSPRIL--------------RELCDRHLEYTTWSNIR-VCVGT Synj_DmelP055_AA SELADRARILLPSNMLHAPTTVL--------------RELCKRYTEYVRPRMAR-VAVGT Synaptojanin_SpurP121_AA GSLANKASSLLPSSHLHASPDIL--------------QGVCEREGDFTSSSRFR-ICVGT SYNJ1_HsapP110_AA SDLADKARALLTTGSLRVSEQTLQSASSKVL------KSMCENFYKYSKPKKIR-VCVGT DDB_G0281427_DdisP049_AA AKQ--------------------------------------IAIEKIPLWNLETDHYLHN DDB_G0279397_DdisP051_AA LSNPSPILNPLGTSGGYSSNDFINSSSSSLSSSTSSSLLQQQLYGSFSQSPQISNGSSTT DDB_G0274537_DdisP052_AA VITGKQLIGSFGGKYIYRIENCNLILISNNPTDLSEHDRKMESTYKKSLKNLLKSNFYYC C34B7.2_CeleP032_AA ------------------DYN-------LHFP---------------------------- FIG4_ScerP064_AA ------------------DFY-------LHN----------------------------- CG17840_DmelP052_AA ------------------DYD-------MH------------------------------ FIG4_MbreP070_AA ------------------DEP-------LWL----------------------------- FIG4_HsapP107_AA ------------------DFY-------LHHKN--------------------------- FIG4_SpurP118_AA ------------------DYY-------LHHTDASG------------------------ INPP5_AqueP152_AA MIK---------------TCR-------DNLFPNTSVPVKGWALIEPAGYSFVPTSEGEE W09C5.7_CeleP200_AA ------------------ETI-------QFLVPTQQTVIAGWGLINAFQSSDEID----- DDB_G0290653_DdisP053_AA SSNSNGNNNSGSTNQTNSSSS-------SSNSNSNSGGNSSGGGGGGSSGGGNSQISNII SAC1_MbreP071_AA ------------------PTH-------AWHV---------------------------- SAC1_ScerP042_AA ------------------PVY-------IQLIP--------------------------- sac1_DdisP054_AA ------------------SPL-------IWIF---------------------------- F30A10.6_CeleP073_AA ------------------DLP-------VSL----------------------------- Sac1_DmelP054_AA ------------------GWR-------FFTFP--------------------------- SAC1_NvecP084_AA ------------------DWR-------YMMLP--------------------------- SACM1L_HsapP109_AA ------------------DWK-------FLALP--------------------------- SAC1_SpurP120_AA ------------------DAK-------FMLLP--------------------------- CG7956_DmelP053_AA ------------------DCR-------RLLLGTAQYPVGAWGLIDADPSSGDINETEVD INPP5F_HsapP108_AA ------------------SYM-------KLLLPDDEKFHGGWALIDCDPSLIDATHRDVD INPP5_SpurP119_AA ------------------QCS-------RLLLPKNEAKMNLGGWVLIDCDSGDLDDSGED INPP5_NvecP083_AA SATQDQDVILLL------TYH-------AYYVASPEGESATQDQD--------------- INP51_ScerP033_AA FNISGKIPKD--------DIK-------DWIFP--------------KSMSKEDEMADLY Dd5P3_DdisP050_AA YNVGGVHSSYF-------DLV-------QWLRP----------------DGANCPTPDFY INP53_ScerP068_AA FNVNGATKKV--------DLS-------KWLFP-----------------IGEKFKPDIV INP52_ScerP059_AA FNVNGNSRRA--------DLS-------KWLFP-----------------IGDKFKPDVV Synaptojanin_MbreP072_AA ------------------CID-------EWLI-----------RPRSRLSEDQGNELGIY Synaptojanin_AqueP153_AA WNVNGGKQMRSIALKKE-SMH-------DWLLDAPVLS-----------GKKSIPPADVY unc-26_CeleP194_AA WNVNGGKNIHNVAFRNESSLS-------HWIFANSMTRLV---------SVEDEQLADIV SYNJ2_HsapP111_AA WNVNGGKQFRSNVLRTA-ELT-------DWLLDSPQLS-------GATDSQDDSSPADIF Synaptojanin_NvecP085_AA WNVNGGRHFRSLAHKHQ-TMH-------DWLLDFHKSLPDSGYSEVK--DVDYSLPTDIF Synj_DmelP055_AA YNVNGGKHFRSIVFKD--SLA-------DWLLDCHALARSKALVDVNNPSENVDHPVDIY Synaptojanin_SpurP121_AA WNVNGGKNSHNIAFKNE-SLT-------DWLLDNPQIT-----------GVDYSVPNDIY SYNJ1_HsapP110_AA WNVNGGKQFRSIAFKNQ-TLT-------DWLLDAPKLA------GIQEFQDKRSKPTDIF DDB_G0281427_DdisP049_AA ITNRKQHHLLAFT-----NWW-------DHSLNQFKKSSLLFNLVSRASMIQMMKAKSLY DDB_G0279397_DdisP051_AA ATTTTATSLQPISTSTNNSSPSSLEKKFIFLNYHPQKEIIRYSCLDSLERVNIVLFFNFF DDB_G0274537_DdisP052_AA FDYNISDNIEN-------HFK-------NHHNKQTNNNTNVNEENTTTTTTTTTTTTTTT C34B7.2_CeleP032_AA -----------YSLKINTDYCAWTLSEKE----------LEDLVFLDYDES-ENSD--GY FIG4_ScerP064_AA -----------AYSLNMPKRSYIHWWNDYNIKSVKEL--INEELIATGNDV-TREK--II CG17840_DmelP052_AA -----------NAFVPRADSKAITDWVRHKVRAC---------LPYSCADS-NKLV--KE FIG4_MbreP070_AA -----------QYS--------------------------------------------DY FIG4_HsapP107_AA -----------TMRLLPTRRSYTYWWTPE----------VIKHLPLPYDEVICAVNLKKL FIG4_SpurP118_AA -----------TGT-------------------------DKSMLPLLIKDG-------LI INPP5_AqueP152_AA DAV--------LLLCKERRHICVANYNNEFEQVA-----CCIRIPLDRIER-ISIGPIGS W09C5.7_CeleP200_AA -----------TVVILTRSNLYIVTYEIDGEKMT-----DVQIVALEDINT-IQTG--TS DDB_G0290653_DdisP053_AA NVGSSNRSLY-AVLCINPSQSMITSWVKSNGRRKDYH--FSSIYLLEKSKL-NHRQLNLY SAC1_MbreP071_AA --------------------------------------------TLSRGSH-TSVSMGSK SAC1_ScerP042_AA -----------MIICAALTVLGAT-------------------IFFPKDRF-TSSK--NL sac1_DdisP054_AA --------------SFVFAAIFL----------------ANLYLPSATSSI-GGFI--SQ F30A10.6_CeleP073_AA -----------ESSILSTDQNGLALIAAL----------FAMSMTILCLLV-ADNF--TA Sac1_DmelP054_AA -----------SVLLVAVAMFMIT-------------------MTYPAEFN-TENL--LF SAC1_NvecP084_AA -----------LILLFGFSMFIIS-------------------VLIPSTDY-GIQF--LY SACM1L_HsapP109_AA -----------IIMVVAFSMCIIC-------------------LLMAGDTW-TETL--AY SAC1_SpurP120_AA -----------AIAMVAFSMLLIS-------------------MLIPAAEL-HLQI--AY CG7956_DmelP053_AA -----------TILLLTDDCYIVAEYDSHLDKIV-----RFEKVQLTQVRL-IELGMHQQ INPP5F_HsapP108_AA -----------VLLLLSNSAYYVAYYDDEVDKVN-----QYQRLSLENLEK-IEIGPEPT INPP5_SpurP119_AA DRD--------IILIISEKAYYIASYDDEAEKIT-----QYERIPIDAMTA-VGIGSATT INPP5_NvecP083_AA -----------VILLLTYHAYYVASYDDEAEQIT-----QYERIAIEDVEK-IEIAAWSL INP51_ScerP033_AA VIGLEEVVELTPGHMLATDPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQL-GGIL--LL Dd5P3_DdisP050_AA VLGLQEVVELTAGQILATDSSIGKQWEDAIERALPKVSPNVKYIKLQSSQL-VGLL--MA INP53_ScerP068_AA VLGLQEVIELSAGSILNADYSKSSFWENLVGDCLNQY--DDKYLLLRVEQM-TSLL--IL INP52_ScerP059_AA VLGLQEVIELTAGSILNADYTKSSFWETMVTDCLNQY--EEKYLLLRVEQM-SSLL--IL Synaptojanin_MbreP072_AA AIGFQEMVDLNASNMIKTAQTNRLEWANEICTIL-----GDDYALLTSVQL-VGIC--LF Synaptojanin_AqueP153_AA AIGFQELVALTTSNLVSTNSSNRYAWAAELQHVLSR---DHEYSLLTAEQL-VGVC--LY unc-26_CeleP194_AA AIGVEELVDLNASNMVKASTTNQRMWCESIRKTLSE---KAPFVLIGSEQL-VGVC--LF SYNJ2_HsapP111_AA AVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISR---SHRYILLTSAQL-VGVC--LY Synaptojanin_NvecP085_AA AIGFEELVDLNASNMVSTSSTQRKEWGEELRRVISR---DFPYVLLTCEQL-VGVC--LF Synj_DmelP055_AA AIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISR---DNDYVLLTYQQL-VGVC--LY Synaptojanin_SpurP121_AA AIGFEEMVDLNAGNIISASTTNQRKWGVELQKSLSR---DHKYVLLVCEQL-VGVC--LY SYNJ1_HsapP110_AA AIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISR---DNKYVLLASEQL-VGVC--LF DDB_G0281427_DdisP049_AA EFEDTFYK---TDRLTLFEKHFSYRFCDPIRFRN-----QSSPLTITIENP-NQNLSTPY DDB_G0279397_DdisP051_AA QIVSKMGSELGIPSLNELLSFGSSTLDFTLTTFKSLNLFGPLIEFYVCSSD-ISSI--LY DDB_G0274537_DdisP052_AA LTESQE-----TIYHLFEVFNSRFYWNKHLQTNLIQGG-FYNWVLPLIRGY-VEII--NF C34B7.2_CeleP032_AA VEIRSIDVDGRRGSEG------------------------SEYRTLL------------- FIG4_ScerP064_AA KNVRGYPGAFDNYWNE------------------------YY------------------ CG17840_DmelP052_AA LFRVHSSGLEMIDAYS------------------------NYHQSFKWTD---------- FIG4_MbreP070_AA FLHYPHA----------------------------------------------------- FIG4_HsapP107_AA IVKKFHKYEEEIDIHN------------------------EFFRPYELSSFDDTFCLAM- FIG4_SpurP118_AA LATIPLMVLFYTGSKV-------------------------------------------- INPP5_AqueP152_AA ILKTSRRVYMRLFYTL------------------FPGCSCYFTFRPIHSISLEEDKLTLL W09C5.7_CeleP200_AA GNNRQCARLETLEGVF------------------------IWRPSTVRLFNNTAIRLKSL DDB_G0290653_DdisP053_AA YLENPSPECFQFTSSLQREQFLQELYKHSFAKRFLPLDDQSTTSKLFDDKNNQLNEKINK SAC1_MbreP071_AA LIAPGTASKLARTHS--------------------------------------------- SAC1_ScerP042_AA LYFAGASIVLALSTKF------------------------MF------------------ sac1_DdisP054_AA TTVLVGSVFFALKLAM------------------------KYQAS--------------- F30A10.6_CeleP073_AA TIFWMV----IFFVCM------------------------MF------------------ Sac1_DmelP054_AA MLFWGA------------------------------------------------------ SAC1_NvecP084_AA ILFWGAAVLFTLYVVM------------------------FF------------------ SACM1L_HsapP109_AA VLFWGVASIGTFFIIL-------------------------------------------- SAC1_SpurP120_AA ILFWLAATVICVGLMG------------------------VF------------------ CG7956_DmelP053_AA TKIFQGSAPAHLCLRL------------------------NYSVDEQEGYFHMFRSANLR INPP5F_HsapP108_AA LFGKPKFSCMRLHYRY------------------------KEASGYFHTLRAVMRNPEE- INPP5_SpurP119_AA FFSHAKQRCVRIYHSV----------------------------QGQDGYFSTLKALPSQ INPP5_NvecP083_AA IFVRSLFSSPSKCSHV------------------------RTIQHRTPEEAKG------- INP51_ScerP033_AA LFMNETEYSKVKHIEG------------------------DVKKTGFGGMASNKGAVAVS Dd5P3_DdisP050_AA IYVREDAIHYFREVQI------------------------QNVKCGMNGLAGNKGGIGVR INP53_ScerP068_AA FFVKADKAKYVKQVEG------------------------ATKKTGFRGMAGNKGAVSIR INP52_ScerP059_AA FFARSDRAYNIKEVGG------------------------STKKTGFGGITGNKGAVAIR Synaptojanin_MbreP072_AA VLVRTDLVDVVRDVCT------------------------CTVKTGAGGKVGNKGAVAVR Synaptojanin_AqueP153_AA IFVRPHLIPFIRDVGV------------------------SAVKTGIGGAAGNKGGVAIR unc-26_CeleP194_AA LFARPRVSPYLKDFAV------------------------ASVKTGMGGATGNKGSVAFR SYNJ2_HsapP111_AA IFVRPYHVPFIRDVAI------------------------DTVKTGMGGKAGNKGAVGIR Synaptojanin_NvecP085_AA VFARPHLVPYIRDVAV------------------------STVKTGLGGSAGNKGGVAIR Synj_DmelP055_AA IYIRPEHAPHIRDVAI------------------------DCVKTGLGGATGNKGACAIR Synaptojanin_SpurP121_AA IFIRPQHAPFIRDVAV------------------------DTVKTGLKGAAGNKGGVAIR SYNJ1_HsapP110_AA VFIRPQHAPFIRDVAV------------------------DTVKTGMGGATGNKGAVAIR DDB_G0281427_DdisP049_AA LQQKQKLDSSQNQLNN------------------------NDFDQQQQQQQQQQQQQQQQ DDB_G0279397_DdisP051_AA HNNPPTPNPIMRELVQ----------QLQQQQQQQQQQQNSTSTTKTNSSNSNTLQSSTT DDB_G0274537_DdisP052_AA FIERNDIEFLLISRRS------------------------KFRAGTRYNTRGSDHNGNVA C34B7.2_CeleP032_AA ----------------------FSSHEDFRDYHRTYEFTSLDDRIGRLFSIE-------- FIG4_ScerP064_AA ----------------------LPRSVTWIRDLFAYNMNSTRR-----YHNA-------- CG17840_DmelP052_AA ----------------------FSEHIAFEISQLALRYMPTFRTNFSPFQRQ-------- FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ----------------------TSSARDFMPKTVGIDPSPFTVRKPDETGKS-------- FIG4_SpurP118_AA ----------------------SQSSWVTPPTSDQRGQSASFRNFADMFPSM-------- INPP5_AqueP152_AA S---------------------LSQELVEVQPTITLQEQRLTKKASK-FHEG-------- W09C5.7_CeleP200_AA EE--------------------ANEYISSVAEQIQVGRNMLTGAEGS-VVPV-------- DDB_G0290653_DdisP053_AA LTSDMFTSSIDSSNNQSPPPNSNSNSNSSSPNLIPSSPPPIRHRLLDIFNAY-------- SAC1_MbreP071_AA ----------------------TSEKSSLLPTTLPLPTISLLSPTSS-HLEE-------- SAC1_ScerP042_AA ------------------------------------------KNGIQ-FVNW-------- sac1_DdisP054_AA ------------------------------------------------IVDK-------- F30A10.6_CeleP073_AA ----------------------------------------IFLNGEE-FVNA-------- Sac1_DmelP054_AA --------------------------------MIAVSATGILHYGVE-FVQW-------- SAC1_NvecP084_AA --------------------------------------------GTE-YVDQ-------- SACM1L_HsapP109_AA ------------------------------------------YNGKD-FVDA-------- SAC1_SpurP120_AA --------------------------------------------GIE-FIDQ-------- CG7956_DmelP053_AA FFNNMAYVIKTQEE--------VAESMTSIVEMFRIALDNAGNTEVR-YITG-------- INPP5F_HsapP108_AA ----------------------DGKDTLQCIAEMLQITKQAMGSDLP-IIEK-------- INPP5_SpurP119_AA SKE-------------------AAEDILHALVEALAKARAANNLGLKVVEDK-------- INPP5_NvecP083_AA ----------------------MFSERDLEIYPMEKANGIFFERNIGIFLPW-------- INP51_ScerP033_AA FKY-------------------SATRFCVLVSHLAAGLENVEQRHND-YKTI-------- Dd5P3_DdisP050_AA LLF-------------------SDTSFTFVTAHFAAGQSNVEDRISD-FREI-------- INP53_ScerP068_AA FEY-------------------GATSFCFVNSHLAAGATNVEERRSD-YESI-------- INP52_ScerP059_AA FDY-------------------GATSFCFVNTHLSAGASNIDERRND-YNNI-------- Synaptojanin_MbreP072_AA LRL-------------------YNTPICFICSHLTAGKSHVAERNQD-YHDI-------- Synaptojanin_AqueP153_AA LLL-------------------HSTSLCFVCSHLAAHQTKIVERNQD-FAEI-------- unc-26_CeleP194_AA IVV-------------------FSTSICFICSHFAAGQNEIRDRNED-FATT-------- SYNJ2_HsapP111_AA FQF-------------------HSTSFCFICSHLTAGQSQVKERNED-YKEI-------- Synaptojanin_NvecP085_AA LLL-------------------HATSICFICSHLAAGQSGVQDRNND-YLDI-------- Synj_DmelP055_AA FVL-------------------HGTSMCFVCAHFAAGQSQVAERNAD-YAEI-------- Synaptojanin_SpurP121_AA FVF-------------------HGTSMCFVCAHLAAGQSHIKDRNDD-YAEI-------- SYNJ1_HsapP110_AA MLF-------------------HTTSLCFVCSHFAAGQSQVKERNED-FIEI-------- DDB_G0281427_DdisP049_AA QQQ-------------------QSNQLNQQQQQLNDEDNNNNNNNNNNNNNN-------- DDB_G0279397_DdisP051_AA TSTQANNNNNNNNNTNGILNKSLTSTVSAVTLLSSSSPSPSSLSSSSSTNKN-------- DDB_G0274537_DdisP052_AA NYV-------------------ETEQIISHQDPTSGKKTTFSFVQTRGSIPLIWEQTGRK C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA -----------------------------------------------IVYLISPSEWAA- W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA ----------IGSWNMENININGGFLSEWLPKDKDLYSIAAQRIASDRKSPDGFLMNYR- SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA --------------------------GVLQRRKSKLPTLDVPRGMPRNLSESQLVQLSS- INPP5F_HsapP108_AA ---------------------------------KLERKSSKPHEDIIGIRSQNQGSLAQ- INPP5_SpurP119_AA ---------------------------------MEKKKSRVSQEVIRLTSQKRFTMWLQD INPP5_NvecP083_AA --------------------------------------------------KRPKVILCQ- INP51_ScerP033_AA -----------------------------------AKSIRFSKGLR--IKDHDAIIWMG- Dd5P3_DdisP050_AA -----------------------------------DSTLAFGRQGQFKVSDSDYSFWLG- INP53_ScerP068_AA -----------------------------------VRGITFTRTKM--IPHHDSIFWLG- INP52_ScerP059_AA -----------------------------------YRNITFPRSKT--IPHHDSLFWLG- Synaptojanin_MbreP072_AA -----------------------------------YRRIDFGKGRV--LDSHSAVFWFG- Synaptojanin_AqueP153_AA -----------------------------------HRKVLFPMNQT--ISSHDYVFWCG- unc-26_CeleP194_AA -----------------------------------LKKIRFPLGRE--IDSHDVIFWLG- SYNJ2_HsapP111_AA -----------------------------------TQKLCFPMGRN--VFSHDYVFWCG- Synaptojanin_NvecP085_AA -----------------------------------ATRTAFPMGRT--IRSHDYVFWCG- Synj_DmelP055_AA -----------------------------------TRKLAFPMGRT--LKSHDWVFWCG- Synaptojanin_SpurP121_AA -----------------------------------SSKIMFPMGRS--LESHDYVFWCG- SYNJ1_HsapP110_AA -----------------------------------ARKLSFPMGRM--LFSHDYVFWCG- DDB_G0281427_DdisP049_AA -------------------NNNNNNNNDNINNNNINSNNNNEQDESKRYDIKRWVVSLS- DDB_G0279397_DdisP051_AA -------ASTSTNSTTSTTTTTPTTITTITTSHLLNSQRKYQLTHSDENRSYQYLLMLGN DDB_G0274537_DdisP052_AA IKPEIKITQDNQLNSNSFRAHFDEQIKLYGPGPQVLVTLLDQKGSEAELGEAYRMMAVT- C34B7.2_CeleP032_AA NRAIQV-----------------------------------DGINEEPTTHAQFLK---- FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA --------------------------------------------------------IQTS FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA KEAYGV-----------------------------------QIKPPERKDVPLYQRFSTV INPP5_AqueP152_AA DGWENV-----------------------------------LIPVKETRETAPDKG---- W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA QYWFYL-----------------------------------IRKYLGPQYCTIATAVSDN SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA KALSNM-----------------------------------AGQFSKLGQTFKKPQAHPS INPP5F_HsapP108_AA GKNFLM-----------------------------------SKFSSLNQKV--------- INPP5_SpurP119_AA KFVPES-----------------------------------VLAKRKGGNQGGEQSPSDQ INPP5_NvecP083_AA KVKMAI-----------------------------------HFKMTAAVLLGIADAFSTA INP51_ScerP033_AA DFNYRI-----------------------------------LMSNEDVRRKIVSKE---Y Dd5P3_DdisP050_AA DFNFRI-----------------------------------DLPDEEIRRCVYDQQ---F INP53_ScerP068_AA DMNYRI-----------------------------------NLPNEDVRRELLNQEEGYI INP52_ScerP059_AA DLNYRI-----------------------------------TLTNDEVRRELRAQKDGYI Synaptojanin_MbreP072_AA DFNYRI-----------------------------------DLENLECRQACADKD---L Synaptojanin_AqueP153_AA DLNYRI-----------------------------------DLPSSIAKDAISKEE---W unc-26_CeleP194_AA DFNYRI-----------------------------------NLSGDEVKNAVRNGD---Y SYNJ2_HsapP111_AA DFNYRI-----------------------------------DLTYEEVFYFVKRQD---W Synaptojanin_NvecP085_AA DFNYRI-----------------------------------DMPMDEVKSLIQLKD---W Synj_DmelP055_AA DFNYRI-----------------------------------DMEKDELKECVRNGD---L Synaptojanin_SpurP121_AA DFNYRI-----------------------------------DKDNDEVKDLVAIHD---Y SYNJ1_HsapP110_AA DFNYRI-----------------------------------DLPNEEVKELIRQQN---W DDB_G0281427_DdisP049_AA KRNNSI-----------------------------------FKKNDNSSVVGLNDSNSII DDB_G0279397_DdisP051_AA CFGFSSRFFPFNSSIGKDLSPYWISSAPSSCVMSLPTLLCNNGSNLNPSILIRDIDDFCW DDB_G0274537_DdisP052_AA SGYREI-----------------------------------DFVPFDFHHFCQGNRFDRV C34B7.2_CeleP032_AA -------------------------------LWKTTETKEKDQKKPNKKDKEEKESDDED FIG4_ScerP064_AA --LSKQDKAMSPFTSRK----------------QSWLNNKLKMITSSKSLEKAEGRVVET CG17840_DmelP052_AA RKARQNPSMTGQSSTGS--------------MNSNSSSSSEGDDSSSDEELSAS---FAE FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA -------VLGNKSNREE--------------AVLQRKTAASAPPPPSEEAVSSSSEDDSG FIG4_SpurP118_AA GLNSQQEVMTLHSDISDS-------------RIKRCMKRATRIIPSSGFS-------LDT INPP5_AqueP152_AA GSIFYDNVSSSSSASVR--------------LSIPSPNEEEKGGEGERVSSQSSITDDDN W09C5.7_CeleP200_AA -AKITIPQMSVHRKSMA--------------AMGALFGKIKRVGKPSSLSKSAST--IST DDB_G0290653_DdisP053_AA TASIVLLKKSLVNSANN--------------ISISYLQKRLPYGKKQQQSQQSQQSQFSS SAC1_MbreP071_AA ---------------------------------------------------------VVA SAC1_ScerP042_AA ---------PKLVDVGF--------------LVVHQTHDKEQQFKGLKYAQSPK---FSK sac1_DdisP054_AA --------------------------------------------PTL----------FKL F30A10.6_CeleP073_AA --------------------------------------------PKLKLD---------- Sac1_DmelP054_AA --------------------------------------------PR-----------LFP SAC1_NvecP084_AA --------------------------------------------PKL----------VQT SACM1L_HsapP109_AA --------------------------------------------PR-----------LVQ SAC1_SpurP120_AA --------------------------------------------PKL----------SQA CG7956_DmelP053_AA SLAATMNPQVMRQRDSE--------------IESGQEAEKAVFTLGRKHRNSNSASSTDT INPP5F_HsapP108_AA -KQTKSNVNIGNLRKLG--------------NFTKPEMKVNFLKPNLKVNLWKS---DSS INPP5_SpurP119_AA PSSRQLIKPIRAQVMSR--------------YFQSMGDKVSNLNPLKKVRLRK----RQS INPP5_NvecP083_AA RGALGLKITETKLDRKRSKPLPDVIQISSKSRLSGWSKPNAKVKSKHELAAHEENSTFQT INP51_ScerP033_AA ASLFEKDQLNQQMIAGE--------------SFPYFHEMAIDFPPTYKFDPGTKN--YDT Dd5P3_DdisP050_AA PKLYNYDQLRKCMEAGR--------------VFNGYREETIAFPPTYKYDLNSTQ--YDT INP53_ScerP068_AA DKLLHFDQLTLGINSGS--------------VFEGFKEPTLKFRPTYKYDPGTGT--YDS INP52_ScerP059_AA DRLLQYDQLTQEINEGV--------------VFQGFKEPTLQFRPTYKYDYGTDN--YDT Synaptojanin_MbreP072_AA ATLKEHDQLTRERARLA--------------VFDSFNEPPIHFLPTYKYDFDSDV--YDT Synaptojanin_AqueP153_AA DKLVRHDQLTKQKKLGK--------------VFFGFAEGDLTFAPTYKYDQFSDD--YDT unc-26_CeleP194_AA AKLVENDQLTQQKALGQ--------------TFVGFNEGQLTFAPTYKYDTFSDD--YDT SYNJ2_HsapP111_AA KKLLEFDQLQLQKSSGK--------------IFKDFHEGAINFGPTYKYDVGSAA--YDT Synaptojanin_NvecP085_AA DALAQNDQLNKQRQEHK--------------VFRGYVEGELRFAPTYKYDLFSDD--YDT Synj_DmelP055_AA STVLEFDQLRKEQEAGN--------------VFGEFLEGEITFDPTYKYDLFSDD--YDT Synaptojanin_SpurP121_AA EALKECDQLLLERRKGN--------------TFQGFAEGTIRFAPTYKYDLFSED--YDT SYNJ1_HsapP110_AA DSLIAGDQLINQKNAGQ--------------VFRGFLEGKVTFAPTYKYDLFSDD--YDT DDB_G0281427_DdisP049_AA AEFNRNKNKKLGSNIKLHNGPDYQPLKHFGIHLGTNNFDLEIFNQYINYPHLESPLEYNS DDB_G0279397_DdisP051_AA ISPLDTNQVEMVIYLGQPCVVTEICITVAHGINGDTYPKTMDVLLGNYYDQVSFVLQDVE DDB_G0274537_DdisP052_AA DILIDQLEENIHQHIGY--------------TERNSEQGYTQHQHGLTRTNCLDC--LDR C34B7.2_CeleP032_AA DDEEISTQWSDVVEAQQEWYDL-------------------------------------- FIG4_ScerP064_AA TDLDRDTSPKQELELYEHYLHI-------------------------------------- CG17840_DmelP052_AA KEANQTE----------------------------------------------------- FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA TDREEEGSVSQR------------------------------------------------ FIG4_SpurP118_AA SVRVTPPTVD-------------------------------------------------- INPP5_AqueP152_AA DESFSAPASPSKSRESKITTLQ----------------------------E--------- W09C5.7_CeleP200_AA AQLPETD----------------------------------------------------- DDB_G0290653_DdisP053_AA SNSTSNSNSSSTNNSNSNSPNIGGSPPLQSAAPPPLPPREKESQLPPTKSELKEHHNNHH SAC1_MbreP071_AA ADGKRD------------------------------------------------------ SAC1_ScerP042_AA PDPLKRD----------------------------------------------------- sac1_DdisP054_AA DSIYKN------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA PISFRDP----------------------------------------------------- SAC1_NvecP084_AA QLKDKNV----------------------------------------------------- SACM1L_HsapP109_AA KEKID------------------------------------------------------- SAC1_SpurP120_AA KVKSD------------------------------------------------------- CG7956_DmelP053_AA DEHDNS------------------------------------------------------ INPP5F_HsapP108_AA LETMENTGVMDKVQAE-------------------------------------------- INPP5_SpurP119_AA NPQTESIGMENRALAEDEESQD-------------------------------------- INPP5_NvecP083_AA RLRDKTPPKTLQSFLEARVGDM-------------------------------------- INP51_ScerP033_AA SEKMRIPAWTDRILSRGEV----------------------------------------- Dd5P3_DdisP050_AA SQKQRSPAWTDRIVWSNKVHHD-------------------------------------- INP53_ScerP068_AA SEKERTPSWTDRIIYKGENLLP-------------------------------------- INP52_ScerP059_AA SEKARTPSWTDRIIYKGENLHP-------------------------------------- Synaptojanin_MbreP072_AA SEKQRVPSWTDRAQQIDMSKEL-------------------------------------- Synaptojanin_AqueP153_AA SEKCRVPAWCDRILWQRKSFLP---------------PVTDQRAIARLRDDEPDNDLEES unc-26_CeleP194_AA SEKCRAPAWTDRILWKDQRKKG-------------------------------------- SYNJ2_HsapP111_AA SDKCRTPAWTDRVLWWRKKHPF-------------------------------------- Synaptojanin_NvecP085_AA SEKMRIPAWTDRVLWRRRKPRYKSADHVKKHVIKKNERNVSENLLLGDEIVNDDAEEEEE Synj_DmelP055_AA SEKQRAPAWTDRVLWRRRKALA-------------------------------------- Synaptojanin_SpurP121_AA SEKMRTPAWTDRILWRRHKPFY-------------------------------------- SYNJ1_HsapP110_AA SEKCRTPAWTDRVLWRRRKWPF-------------------------------------- DDB_G0281427_DdisP049_AA QDQYSLKYYKEYLKNTNEKSKS-------------------------------------- DDB_G0279397_DdisP051_AA LPRCTTGTKLSYILPNSPWEAYSSRFNQTNNLGGGVSSDRYFNRIVKLLFTGTHTPMTIG DDB_G0274537_DdisP052_AA TNLVQSMIGVSVLERQLKRLGF-------------------------------EWRIKDQ C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA -----------------------------------------------------RSRLFSH W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA HHHHNNNNNNYSSGSNNSNSSNSSSSSVVNFFFGSKKLKE-------------MSNKIIE SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ---------------------------------------------------------LYE INPP5F_HsapP108_AA -----------------------------------------------------SDGDMSS INPP5_SpurP119_AA -----------------------------------------------------ELDGIDD INPP5_NvecP083_AA -----------------------------------------------------PRPYSDS INP51_ScerP033_AA ---------------------------------------------------------LEQ Dd5P3_DdisP050_AA ---------------------------LRQLYYHRQEILASDHRPVSSYFQL-EVTKIDK INP53_ScerP068_AA ------------------------------LSYSDAPIMISDHRPVYAAYRA-KITFVDD INP52_ScerP059_AA ------------------------------LAYSDAPLKISDHKPVYAAYRA-NVKFVDE Synaptojanin_MbreP072_AA ----------------------------RVREEILIELRKE------------LATLAVE Synaptojanin_AqueP153_AA DCHPSSVGKVYKRELTSGHQSLSWWNPGRLLYYGRGELKTSDHRPVIAYFEI-DVFRINE unc-26_CeleP194_AA --------------------------KTQLLSYDRSELKTSDHRPVGAVFKV-ETFKVGG SYNJ2_HsapP111_AA -DKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEV-EVQEVDV Synaptojanin_NvecP085_AA DEDDDDDEQESTTEANPESLGNIHFHPGKVLYYGKAELKTSDHRPVVGLIEV-EIQKVDW Synj_DmelP055_AA ----------------EGDFAASAWNPGKLIHYGRSELKQSDHRPVIAIIDA-EIMEIDQ Synaptojanin_SpurP121_AA -FKQTSDSKELSSQIGNTNLVIYNWDSGRVLHYGRAELKTSDHRPVVAIIEV-EVQLVDE SYNJ1_HsapP110_AA -DRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDI-DIFEVEA DDB_G0281427_DdisP049_AA -----------------------------------------------------KLYSSLN DDB_G0279397_DdisP051_AA KVEVFGYHSNSYFNNNNQLTLNINPTYRNSIDFNKNYHSNSSYTQSITNDIYHQMERKKQ DDB_G0274537_DdisP052_AA SLPGTRSIKLAWANNGDAISFQYAGTQALKGDYTRTGKRNTK-----------GVFRDGV C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA GSAEDLPSRVIQDDSGKGERRRHKRRESIGYVILASASSSIDQNESSPDQLIQIDDFQFR W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA STLSQKSTEILFKDKYKDVQFGTTISLQLRETSLCFINFCNNNVSQSANPELAAEQESSL SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA PEVDSDVEIAMDKSNYNENAFLPSVGIVMGNQKEDSPSSSDEIRHLEQKDSMCKTTEDVL INPP5F_HsapP108_AA DNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDS INPP5_SpurP119_AA SDDEILLDSSSSDDTSFDGLSLGACLEILGGNADVDPEDDPHNNSVVSHDGEIILTTCGV INPP5_NvecP083_AA CLLRSVVDEDFNGVRERTGTLSAPTSSASSSVSGDDSDSGATDEMFEKAGEELLEMRMRA INP51_ScerP033_AA LEYKCCEDILFSDHRPVYAIFRARVTVV-------------------------------- Dd5P3_DdisP050_AA DKERTLRQELYEQKSSQFITTSQSTNNLINTTNQNGKDGANLITKEFEQLTLIKQSASTP INP53_ScerP068_AA KERLSLKKRLFTEYKQEHPEEPGSLISDLLSLDLDNKSTDGFKSSSESSLL--------- INP52_ScerP059_AA KEKLNLVEKLYAEYKNTHPEALTTGPDELSHARMEKQKESIPLDATVQSAGIKLIDLDDT Synaptojanin_MbreP072_AA CQQGNLPAVVVQRAMEQFGAVVIVDQLPSGYLTLVTFAAIESAEKALRSVDPTIEGLPVS Synaptojanin_AqueP153_AA KERERVRGTVLEDMGPADATVRVKPLSA----------DYNSIDTKQLVKALNEYGTIVL unc-26_CeleP194_AA RKCVELIEDVVESMGPPDGTIIVSIAGKPRFPPQMFPPIHEKLKELGAQVQLSKFDDGDL SYNJ2_HsapP111_AA GARERVFQEVSSFQGPLDATVVVNLQSP----TLEEKNEFPEDLRTELMQTLGSYGTIVL Synaptojanin_NvecP085_AA EHQHQIHDHVMQSMGPADPTVVVSSDQT--------GDGDEGIDVSELLEVLEPCGDAVL Synj_DmelP055_AA QRRRAVFEQVIRDLGPPDSTIVVHVLESSATGDEDGPTIYDENVMSALITELSKMGEVTL Synaptojanin_SpurP121_AA DTRESIFHDVFCQQGPPDATVILSL----------------------------------- SYNJ1_HsapP110_AA EERQNIYKEVIAVQGPPDGTVLVSIKSSLPE-----NNFFDDALIDELLQQFASFGEVIL DDB_G0281427_DdisP049_AA ENKSNENNKINLKNSKVLSSSTPILSSSSSTHNNNNNTNSNNNEHTSLIDRLINDQENVN DDB_G0279397_DdisP051_AA QQQKSNNSISNTFINYQIDNILNILNQSSSSSSSSSSSPISPSSPNGSKNNSFNDYNSLL DDB_G0274537_DdisP052_AA NSLTRYYINNFLDKIRQVSIDLFLGLTTVDTYKSAQNFRSIQNEYDWGESRMDAINNCVD C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA ERV--------------------------------------------------------- W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA ITYIKNKQYINGSSRYVFWSGDYDINTLTFNRDTSSIWRPLTKESSLSTTEAGRGVVYWK SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------------------------------------------------ INPP5F_HsapP108_AA SVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYCHRFVQDAQNKVTH INPP5_SpurP119_AA LAVDQERNMRSLNLRRITPRKNYHRDAADNANMIANANEERVR----------------- INPP5_NvecP083_AA EQQEAKEGSDNMSENGSKMFGENGHNLAKST------------ER--------------- INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA NLQKGRSNTTNIQYQITSTNQISNTNNNTIQQQQHHQELVNVTTTRKNSLNSNNNNNNNN INP53_ScerP068_AA ------------------------------------------------------------ INP52_ScerP059_AA SSCVSPLLSGPSPQPSVVGPGGLSNVSPDKSKLNVL------------------------ Synaptojanin_MbreP072_AA LRLLD-------GSDAGSWASFDTSVAESFDLSDADVDDSGISTADDHEARATLAYLDQL Synaptojanin_AqueP153_AA VRVTDEETCVTFHSAKSAIDAVSFNGQEVNGVAVEVKLSEVSMTDWTGNSLQLLTAAELD unc-26_CeleP194_AA WIVLNSGEMALAALSMDGLKIGGTDQINVKLKSPDWAYALKPHLSDFDLE---------- SYNJ2_HsapP111_AA VRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAP Synaptojanin_NvecP085_AA VRVVDEEIIVTFDDGRSALKALELDGKKISGKTAKIRLKCDSSLSKTDLTLQSVTSNTSV Synj_DmelP055_AA VRYVEDTMWVTFRDGESALNASSKKSIQVCGLDLILELKSKDWQHLVDSEIELCT----- Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA IRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIAL DDB_G0281427_DdisP049_AA SNNNNNNNNNNNNNNINSNSNSNSNSNSNNNHNHNIANNNHYNYTNNNNNNGNQQKQQHQ DDB_G0279397_DdisP051_AA KHQQHQQQKQQLPIEMLKTDSPNITSEQQDEILLFNDYNNNENQVKQKQQQQQQQQVNQK DDB_G0274537_DdisP052_AA HFLRSKESSTLGEGFINAWIVISINKRNQEQERILLLTPSHLVRCKYNFNENKIVHFKQF C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA ------------------------------------------------------------ W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA SLLDPD--------------------------TIFESPLELQ-----SSPTTTTTATTTT SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------------------------------------------------ INPP5F_HsapP108_AA LSETRS------------------------------------------------------ INPP5_SpurP119_AA ------------------------------------------------------------ INPP5_NvecP083_AA ------------------------------------------------------------ INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA INNSNN------------------------------------------------TLVASG INP53_ScerP068_AA ------------------------------------------------------------ INP52_ScerP059_AA ------------------------------------------------------------ Synaptojanin_MbreP072_AA SSGDLD-----------------------------------------SALAEDDKESLYS Synaptojanin_AqueP153_AA TENGEA-------------------------------------------DEIGGEEVLIF unc-26_CeleP194_AA ---------------------------------------------------------SFE SYNJ2_HsapP111_AA VSPTAN--------------------------------------SCLLEENFDFTSLDYE Synaptojanin_NvecP085_AA VGENNEMPGTPLRDRAMSDLLSCSASKHSTLPVLEPIRIQSMDAEDSSSDSEKEEEEEEE Synj_DmelP055_AA ------------------------------------------------------------ Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA PSSTSS--------------------------TLLGEDAEVAADFDMEGDVDDYSAEVEE DDB_G0281427_DdisP049_AA QQHQQQ------------------------------------------------YQQQQH DDB_G0279397_DdisP051_AA QQQQLT------------------------ETIQLNNQIDNNIKIKQYENSIIELNLKGI DDB_G0274537_DdisP052_AA NLTSIK--------------------------RIQMGVIDNN-GKKMNSYAIKIFHKSSG C34B7.2_CeleP032_AA ----------VNAPGNVTTTLQKSPTKRESTPPRNTSRAKRSLLSTGLQFAKDIYHLDHL FIG4_ScerP064_AA -----------------ISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLV CG17840_DmelP052_AA ----------------------------STEPAAATLATGLPSMEEIYGCTINPPSKQSM FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA --------------------------STPVKMTDAGDSAKVTENVVQPMKELYGINLSDG FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA ---PSPRSPSSPPNNTKPPGPTTTISPTISPIPTSTTSPSSFSPTFSPSFSTAFSYNATT W09C5.7_CeleP200_AA -------------------------------------------------------GNESD DDB_G0290653_DdisP053_AA TTSLENENEKGEKEGVENLDNRLASTVIPNTIGNGSYGGVVFSGGISTSPPRSPLSEACL SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA -------------------------TISITSVTDHVGLPTGLLENAPAIRPITPNPLICV INPP5F_HsapP108_AA -------------VSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFL INPP5_SpurP119_AA -------RGRLLSDGEDQSRKYSTLGRVRTQAPVDAADGPDASSKVFADSNGQVEELNAN INPP5_NvecP083_AA -----NEKIDSSMEGDSSIQNLLPEPADGDDLSAVPQPEVNPQAEVTEVSAQSGESPAVN INP51_ScerP033_AA ------------------------DEQKKTTLGTQIYEKIMERLEGLDDDEKIAVLSDDA Dd5P3_DdisP050_AA GSNGVPPRKLSSGRPLPMLPQPIQIPPTQQQQQQQQQQQQQQQQETVNLQKMTGSGGGRK INP53_ScerP068_AA --DIDPIMAQPTASSVASSSPVSSASASLQPVRTQNSSQSRTPIKKPVLRPPPPPAHKSV INP52_ScerP059_AA -----PPPPPTSRHNKEPSSKLLSPTKEISIVSVSPRKGESNLPALERHSTPKPLPPVPA Synaptojanin_MbreP072_AA STTSGSSRVMGRQRTGPVVTKARSESRPPVPQHKPPRPLSRKSSDKPPLPARPGTSSPAT Synaptojanin_AqueP153_AA SGDENDQKIPIDEECEAGGLEPSDFNEKGLEQDDNGYEDDEGLVMQGLEPPKACGLEDSD unc-26_CeleP194_AA VTAEEEALLGGTDGAVFEFADEDEDAISVSSLTLTGSAPDRPRPPSARSEAISVAKLEWP SYNJ2_HsapP111_AA SEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYK Synaptojanin_NvecP085_AA EELSDDDRPEAERGAEESSKQLKEACKSRPPRPAQPKRVPPPRPTARPKRPNTSIHSQDD Synj_DmelP055_AA -----TNTIPLCANPVEHAQLLQAITPELPQRPKQPPTRPPARPPMPMSPKNSPRHLPHV Synaptojanin_SpurP121_AA ---------------------------------------------------TDPHGNQVV SYNJ1_HsapP110_AA LLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSS DDB_G0281427_DdisP049_AA HNHHQQQQKQHDINDSSNSNGGGSGNIISNEGGVILKSPILLPPSKQPIHYTNENYRYQY DDB_G0279397_DdisP051_AA VTFLESLELENKRVQFGISPQERDKILKKLNINSNLLNPDRFIFERDEKIEVNIRKSNKY DDB_G0274537_DdisP052_AA SSSSGSGSGSSNSGSGSISPNSRSNSSAINSRPIKSSSSSNSSLGDSLDLSTSPNDSNFT C34B7.2_CeleP032_AA KTQPEERRYYEKYAITAFKCNVRDWEKVKPTLLSEFKITSEVEPR--------------- FIG4_ScerP064_AA DIAEDFTDVYDDDDDGDDENDEMTTEALLIAPDHVSVDEKFYE----------------- CG17840_DmelP052_AA AVYKKYVQMGKLSSGGARPAQTAVAQRDQELAKIMRGITLRPL----------------- FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA LSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLTPISA--------------- FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA GSLPEKTLPPSLSPVEAITLSAPVCVTDFEPLEGNTAPSTAANTG--------------- W09C5.7_CeleP200_AA ASQKSDHLMTKILKMSQFKSDSPQPEPFSSLLPAISECQTKISLL--------------- DDB_G0290653_DdisP053_AA FQPISCSFSLPILSPYTWLSTLDIPTFIIIRHLKCESPLELVQPFGSKLDAYLEMDAYHI SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA EAHEAFDDREEGVKPVSSTSARDLSLPGLPTHPEANKLKQLTSPL--------------- INPP5F_HsapP108_AA SVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPF--------------- INPP5_SpurP119_AA ITRDSNLTNKDETLPQSPQKRLSNPVVRLPSLDDNFGPLDLTVNP--------------- INPP5_NvecP083_AA LNFQGSRIFQVSYKSLASSDDVKSAAGEGTAEISPQESTNRFRFT--------------- INP51_ScerP033_AA FVIESFEGSDSIAGPTHSPTPIPEPKRGRKLPPPSSDLKKWWIGS--------------- Dd5P3_DdisP050_AA ISSSPSSSFNNTNSIGSSSSPSGAHSPIFDDQFDPRKGRSSPVPQSFNENNNSNQSKMEL INP53_ScerP068_AA SAPAPSTSKEKSPTPQTSTASLSSVTKNIQENKPLAQNRRIPPPG--------------- INP52_ScerP059_AA LSLSKPVSLQKSSSELQHAKETIDNGKIVPRPCPPIRRKSSTAPD--------------- Synaptojanin_MbreP072_AA LSTASTTGAGSSVASTTASSVSSSVSGPPPPRPMPPRATESKPPR--------------- Synaptojanin_AqueP153_AA QYEHNSDSSDDQSPPTIHVDSCDTNHADIDPIPPLVRPTRPPRPP--------------- unc-26_CeleP194_AA TEQPNVLSTSMPTRASSASLANSSWYEHVPPLAPPQSNNNKSPPQ--------------- SYNJ2_HsapP111_AA DDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASIS Synaptojanin_NvecP085_AA GLVGSAPQVNPSEDVIEDFDPLPQKAPKPRRPPPPKRPERPALPKTSALANKSGQLPRAV Synj_DmelP055_AA GVISIVPKPAKPPMPPQPQSQPLIPSPLQPQVAPPRPPAMDTTPS--------------- Synaptojanin_SpurP121_AA FADDEMDAVLDLTASEGEAILVR------------------------------------- SYNJ1_HsapP110_AA PIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGG DDB_G0281427_DdisP049_AA EPEKKTLKDSQTHQSYHYHHSKNQPINIGNANMGDSNNNINVNPN--------------- DDB_G0279397_DdisP051_AA KSTVCQRPQCSKPLVFFDKIRHQQCCYCYKRYCPACVSSNQVKIFEFESTKLISVCYTCA DDB_G0274537_DdisP052_AA TTTTTTTTTTTTTTTTTTTSSSSSTTSNSTTIDDSIIADCTFNQYIIPIPEGESIEFGKD C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA ------------------------------------------------------------ W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA ISDDQSNSALKTSVCKSSSQPSWLNESIELKSFIDDKEYLKTQFIQVALVSKELMDLSLI SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------------------------------------------------ INPP5F_HsapP108_AA ------------------------------------------------------------ INPP5_SpurP119_AA ------------------------------------------------------------ INPP5_NvecP083_AA ------------------------------------------------------------ INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA LIPNQNSTQYQQQQQQQQQQQQQQQQQQQQQ----------------------------- INP53_ScerP068_AA ------------------------------------------------------------ INP52_ScerP059_AA ------------------------------------------------------------ Synaptojanin_MbreP072_AA ------------------------------------------------------------ Synaptojanin_AqueP153_AA ------------------------------------------------------------ unc-26_CeleP194_AA ------------------------------------------------------------ SYNJ2_HsapP111_AA SGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCL------ Synaptojanin_NvecP085_AA STSKPAGKEKHPKASVDDAQMSFLPQIQTTFVNVGVVLCQGGGRTQIGMPFNVQHIGHVS Synj_DmelP055_AA ------------------------------------------------------------ Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA IGAPPSPGVARREMEAPKSPGTTRKDNIGRSQP----------SPQAGLAGPGPAGYSTA DDB_G0281427_DdisP049_AA ------------------------------------------------------------ DDB_G0279397_DdisP051_AA ILIGKQEQLFRKVQISDRQYYLLKSKFKPSFYQKILLDLHFNQNNVNINLNSLSNLPTTY DDB_G0274537_DdisP052_AA LGREISESIRDCFVSLMGYSNINQLSFGPTF----------------------------- C34B7.2_CeleP032_AA --------------------------------------RPTFFTTDDCYRTESP------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ----------------------------------------SDYGTDSYLSVRPPVVP--- FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------FSQDNIYEVQPPRVD--- FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA ----GTGKRFSRWKAKLFKQSQQQEARYEEEEELEEKQSDSRFYVDNVEEEKEEVVAGG- W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA GKGVLPLKDACRDKAYHFKISLSLEDEFSCYLTGDIQVFSKSEINQYIQEQEFKKQQKIL SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ----------------------------------------SKLAKNIGLNLDPRKI---- INPP5F_HsapP108_AA ---------------------------------------------AKIRSSMVQVASI-- INPP5_SpurP119_AA -----------------LPENFVHDHLLAENLRMKYRAHSENSLQDCFMSTTSTEKTETD INPP5_NvecP083_AA ----------------------------------------GRLLGNRSPGNRSPGTQSRN INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA -----------QQQQQQQPQYNSNLYNSGPPPLQPIHQSNLNPNSNYNQQLQQPPPQPIN INP53_ScerP068_AA -------------------FSQNILTPKSTSNLASPMSSKVDLYNSASESTRSAQDA--- INP52_ScerP059_AA ------------------------EISTSTKNSGVSTTEDPEPAKASTKPEKPPVVKKPH Synaptojanin_MbreP072_AA ----------------------------------------PEPPRPEPPRPDPPRAKPPS Synaptojanin_AqueP153_AA -------------------------PMKSSTSSPVISRKPIVKGGGAPTRPLPPSAKPRS unc-26_CeleP194_AA -------------------------------------ACLFNPFTQSAPSPAPPPSTIPL SYNJ2_HsapP111_AA ---LEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKK Synaptojanin_NvecP085_AA IDNFQALLEAAKDDPKLLPSFMTSDAQKTEESDQPSKDSESKTVPDTVKAESMPVPASRQ Synj_DmelP055_AA --------SKSQSPTELVSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPT Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA RPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLP DDB_G0281427_DdisP049_AA ------INTNYNNNNNIINTHHNNNNNNNNNNNTNNNNNNNNFNNNQYHQPIPNSPLRNG DDB_G0279397_DdisP051_AA ESIAEMLTPLAEYPKGGIINSVPTAAFESSPPIESILLAPSILPLNMYWKAPTDINSVDI DDB_G0274537_DdisP052_AA -----------LVEQDFKRKNSSIVSAAYNGLKLGFYSKSPTVQSSKLKSSKNNITSVNI C34B7.2_CeleP032_AA ------------------EVSGNSARFYIKSSHPLTTECSAQDYGFFSKYMQAT------ FIG4_ScerP064_AA ------------------KVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDF CG17840_DmelP052_AA ------------------RKSLTIYAEYCRTRSTFNAVPKLEEFDVLYQYVQKL------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------RKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIRNRYL---- FIG4_SpurP118_AA ------------------RASRAKYEAHVLCGANGPRPCLAKDLSRYREYFREPRQFTRH INPP5_AqueP152_AA ------------------RGRLARSILRGIKTSSSSLTREKVDNVEIIDEEKQLMISAMA W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA QQQQLQQQILQQQYLQQQQILQQQYQQQQQQQQQQRPMSQQLPPPQVPSRVGRQSASVSP SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------ATKTGVLSPTILSAENSPPERDPSSRDHLLELWEAEKCKTKL INPP5F_HsapP108_AA ------------------TQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQ INPP5_SpurP119_AA SIGREGAQATISKIALRFRTLGSMNFNRSGNLRAEQQKEQMQMEMKMRRECKTRFIQL-- INPP5_NvecP083_AA LFASAQSKSRASFSDLRSKLSNLSFANRTARNRSPRLTHNHVDSPDGLVEQKKHRRRKCQ INP51_ScerP033_AA ------------------GKQVKVVLDVDPAVYMINPKRDPNPFVENEDEPLFIER---- Dd5P3_DdisP050_AA HDLQLIDSWGNSSNGYQSREPPPLQPIPQSVYQSQPPPLQPIPQSVYQPTNFALQQPLQP INP53_ScerP068_AA ------------------RQQTPTAFAASRDVNGQPEALLGDENPIEPEEKAKLNHMTLD INP52_ScerP059_AA YLSVAANKLNTSQEHSIKVSPSNSKSEEELPCKKKSKPKVPAKNPELEKLSVHPLKPCDP Synaptojanin_MbreP072_AA ------------------LRSSLVESELKSAANAIAPPRRPSPPRPIHKTWAKPRHIIVY Synaptojanin_AqueP153_AA ASEISSQKVLPPSRPPPPSRPPVPDRPVPPSVPSRPLIPSRPPPPSVPPRPQVPDRPPPP unc-26_CeleP194_AA PPTR--------------GASVGPGPPAVPVRKAPPPPPRPVIPPRPKNM---------- SYNJ2_HsapP111_AA PTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAER Synaptojanin_NvecP085_AA SKAPIPHPSPPMQPAKPPRQHTQCSIDPVPHLKPPGPTEQPVPPKRKASPPSAQPLPPPR Synj_DmelP055_AA RQVGSPKDPIPSDTAY--ETASNIYEEIQEDVPAPRHPPPAGPPPVIGAPMGPPPPLPNR Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA PPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISDG DDB_G0281427_DdisP049_AA FSSINVGGSGFSNSQKKTTNEQQSKHFKDITKQDLKSFYYQSYLSTHSCTSLYPIPPNNQ DDB_G0279397_DdisP051_AA DVMLSYESMVYSISLIVDSIGYHNYDLPIISISYGKTFTTRDHYQEIGQWVLHPNAWSSG DDB_G0274537_DdisP052_AA ------------------SGSPNVYYHHSPSMQKSSIGSNTLPPNSIITNNNNIKNNEKD C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA Q----------------------------------------------------------- CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA K----------------------------------------------------------- INPP5_AqueP152_AA ASRTKFIII--------------------------------------------------- W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA PVTIPTSNVSTNLYVSAQTFPSGIQQPTRSAPSAPSSSPLSKSPNLSFKQQQQQQQPNYS SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA IAL--------------------------------------------------------- INPP5F_HsapP108_AA TRIIQI------------------------------------------------------ INPP5_SpurP119_AA ------------------------------------------------------------ INPP5_NvecP083_AA TKIIEL------------------------------------------------------ INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA MMSPPPLLYSNQKAVYNIPVPSPYNQQQQQPQQPYQQPYQQPYQQPYQQNLYNQPPPLNN INP53_ScerP068_AA SWQPLTPK---------------------------------------------------- INP52_ScerP059_AA N----------------------------------------------------------- Synaptojanin_MbreP072_AA CVCVRVRACVQWM----------------------------------------------- Synaptojanin_AqueP153_AA YVSLYPQGHENDEQ---------------------------------------------- unc-26_CeleP194_AA ------------------------------------------------------------ SYNJ2_HsapP111_AA PSHRKPASDEAPPGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLT Synaptojanin_NvecP085_AA KPSPPPSAVPIPPPRKPSPPPSEPAPPPRQPPPPSTSQPVPPPRQPDPIPTNPAHPTEPP Synj_DmelP055_AA RGPPPIPNRSGNAPPLPTRPANN------------------------------------- Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA KRESPLKIDPFEDLSFNLLAVSKAQLSVQTSPVPTPDPKRLIQLPSATQSNVLSSVSCMP DDB_G0281427_DdisP049_AA DLYSTYVNLPKSLNL--------------------------------------------- DDB_G0279397_DdisP051_AA DPNLVIQPSSCVSFILSKPIQARIISLRFTLPAIPTFLSALQSGIIPSKPQLHIGRISVH DDB_G0274537_DdisP052_AA DKMRSQSFDYSMS----------------------------------------------- C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA ------------------------------------------------------------ W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA SSPSVITPSPSSPISLSQPQIIHKESFEPISTTPIGSFDNNNNNEINSPPIKPFFSMIGS SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------------------------------------------------ INPP5F_HsapP108_AA ------------------------------------------------------------ INPP5_SpurP119_AA ------------------------------------------------------------ INPP5_NvecP083_AA ------------------------------------------------------------ INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA SYNNYNNQNNNNNNQNNNNTYNNPYLGSILD----------------------------- INP53_ScerP068_AA ------------------------------------------------------------ INP52_ScerP059_AA ------------------------------------------------------------ Synaptojanin_MbreP072_AA ------------------------------------------------------------ Synaptojanin_AqueP153_AA ------------------------------------------------------------ unc-26_CeleP194_AA ------------------------------------------------------------ SYNJ2_HsapP111_AA YNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLH Synaptojanin_NvecP085_AA PRQPKPTPAPRPRSWVESQPELHRPPPPIKPKPCQKFKTAVHATKNCEEPESQQYSSMPD Synj_DmelP055_AA ------------------------------------------------------------ Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA TMPPIPARSQSQENMRSSPNPFITGLTRTNPFSDRTAAPGNPFRAKSEESEATSWFSKEE DDB_G0281427_DdisP049_AA ------------------------------------------------------------ DDB_G0279397_DdisP051_AA GVFSDSLSDISTWSSSSLPLSPSDKDLYDNTLYSTSFITAPKRNPMKTNVQIKSNKSIHI DDB_G0274537_DdisP052_AA ------------------------------------------------------------ C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA ------------------------------------------------------------ W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA MVDDIKNSGEMLFKTISNIDPKSILSLNDDSNDPDDENQTQQHQQQNNKNNDENILEDTQ SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------------------------------------------------ INPP5F_HsapP108_AA ------------------------------------------------------------ INPP5_SpurP119_AA ------------------------------------------------------------ INPP5_NvecP083_AA ------------------------------------------------------------ INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA ------------------------------------------------------------ INP53_ScerP068_AA ------------------------------------------------------------ INP52_ScerP059_AA ------------------------------------------------------------ Synaptojanin_MbreP072_AA ------------------------------------------------------------ Synaptojanin_AqueP153_AA ------------------------------------------------------------ unc-26_CeleP194_AA ------------------------------------------------------------ SYNJ2_HsapP111_AA HPKLLNNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISD Synaptojanin_NvecP085_AA LNPGKAQGDDEAPVAPARRRRIPPAIPKRVDIGETAEADRDCFAETK------------- Synj_DmelP055_AA ------------------------------------------------------------ Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA PVTISPFPSLQPLGHNKSRASSSLDGFKDSFDLQGQSTLKISNPKGWVTFEEEEDFGVKG DDB_G0281427_DdisP049_AA ------------------------------------------------------------ DDB_G0279397_DdisP051_AA SLAYQVPNHIRGFSLIITHDENEGVKSQVKGISISFYSVNQKNELSSHQYLTQILVPKCR DDB_G0274537_DdisP052_AA ------------------------------------------------------------ C34B7.2_CeleP032_AA ------------------------------------------------------------ FIG4_ScerP064_AA ------------------------------------------------------------ CG17840_DmelP052_AA ------------------------------------------------------------ FIG4_MbreP070_AA ------------------------------------------------------------ FIG4_HsapP107_AA ------------------------------------------------------------ FIG4_SpurP118_AA ------------------------------------------------------------ INPP5_AqueP152_AA ------------------------------------------------------------ W09C5.7_CeleP200_AA ------------------------------------------------------------ DDB_G0290653_DdisP053_AA ENTEINTEINTEINTEINNENNNENNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN SAC1_MbreP071_AA ------------------------------------------------------------ SAC1_ScerP042_AA ------------------------------------------------------------ sac1_DdisP054_AA ------------------------------------------------------------ F30A10.6_CeleP073_AA ------------------------------------------------------------ Sac1_DmelP054_AA ------------------------------------------------------------ SAC1_NvecP084_AA ------------------------------------------------------------ SACM1L_HsapP109_AA ------------------------------------------------------------ SAC1_SpurP120_AA ------------------------------------------------------------ CG7956_DmelP053_AA ------------------------------------------------------------ INPP5F_HsapP108_AA ------------------------------------------------------------ INPP5_SpurP119_AA ------------------------------------------------------------ INPP5_NvecP083_AA ------------------------------------------------------------ INP51_ScerP033_AA ------------------------------------------------------------ Dd5P3_DdisP050_AA ------------------------------------------------------------ INP53_ScerP068_AA ------------------------------------------------------------ INP52_ScerP059_AA ------------------------------------------------------------ Synaptojanin_MbreP072_AA ------------------------------------------------------------ Synaptojanin_AqueP153_AA ------------------------------------------------------------ unc-26_CeleP194_AA ------------------------------------------------------------ SYNJ2_HsapP111_AA QEKRTALQVFDPLAKT-------------------------------------------- Synaptojanin_NvecP085_AA ------------------------------------------------------------ Synj_DmelP055_AA ------------------------------------------------------------ Synaptojanin_SpurP121_AA ------------------------------------------------------------ SYNJ1_HsapP110_AA KSKSACSDLLGNQPSSFSGSNLTLNDDWNKGTNVSFCVLPSRRPPPPPVPLLPPGTSPPV DDB_G0281427_DdisP049_AA ------------------------------------------------------------ DDB_G0279397_DdisP051_AA ISSTLYFDFPIPLPPNYILAFEFISNYGGKTNSFPKVNLY-------------------- DDB_G0274537_DdisP052_AA ------------------------------------------------------------ C34B7.2_CeleP032_AA ------------------- FIG4_ScerP064_AA ------------------- CG17840_DmelP052_AA ------------------- FIG4_MbreP070_AA ------------------- FIG4_HsapP107_AA ------------------- FIG4_SpurP118_AA ------------------- INPP5_AqueP152_AA ------------------- W09C5.7_CeleP200_AA ------------------- DDB_G0290653_DdisP053_AA NNSDNNISDLQSSENSENL SAC1_MbreP071_AA ------------------- SAC1_ScerP042_AA ------------------- sac1_DdisP054_AA ------------------- F30A10.6_CeleP073_AA ------------------- Sac1_DmelP054_AA ------------------- SAC1_NvecP084_AA ------------------- SACM1L_HsapP109_AA ------------------- SAC1_SpurP120_AA ------------------- CG7956_DmelP053_AA ------------------- INPP5F_HsapP108_AA ------------------- INPP5_SpurP119_AA ------------------- INPP5_NvecP083_AA ------------------- INP51_ScerP033_AA ------------------- Dd5P3_DdisP050_AA ------------------- INP53_ScerP068_AA ------------------- INP52_ScerP059_AA ------------------- Synaptojanin_MbreP072_AA ------------------- Synaptojanin_AqueP153_AA ------------------- unc-26_CeleP194_AA ------------------- SYNJ2_HsapP111_AA ------------------- Synaptojanin_NvecP085_AA ------------------- Synj_DmelP055_AA ------------------- Synaptojanin_SpurP121_AA ------------------- SYNJ1_HsapP110_AA DPFTTLASKASPTLDFTER DDB_G0281427_DdisP049_AA ------------------- DDB_G0279397_DdisP051_AA ------------------- DDB_G0274537_DdisP052_AA -------------------