MUSCLE (3.8) multiple sequence alignment ScerP022_AA ---------------------------------------------------MMTHTLPSE DdisP001_AA -----------------------------------------------------MEQAPNS DmelP010_AA -----------------------------------------MVTTQQTKEICEIIRLKST DmelP004_AA MEKRSGTPINSQKFRKLSDVDMTEVQLNNLDDSSAKETVEIGSFQGNDQSNPVQHTKWFR DmelP001_AA ------------------------------------------------------------ NvecP001_AA ----------------------------------------------------------MI HsapP002_AA ----------------------------------------------------------MI HsapP001_AA ----------------------------------------------------------MQ HsapP003_AA -------------------------------------------MPRIPASPLSCCPPDML HsapP004_AA ----------------------------------------------------------MQ SpurP004_AA ----------------------------------------------------MILLDSTE SpurP003_AA ----------------------------------------------------------MV SpurP001_AA ------------------------------------------------------------ SpurP002_AA ------------------------------------------------------------ DmelP003_AA ----------------------------------------------------------MF DmelP009_AA --------------------------------------------------------MLSL DmelP011_AA ---------------------------------------------------------MRA DmelP013_AA ------------------------------------------------------------ DmelP002_AA ----------------------------------------------------------MV DmelP005_AA ----------------------------------------------------------MA DmelP012_AA ----------------------------------------------------------ML DmelP008_AA -----------------------------------------------------------M DmelP006_AA -------------------------------------------------------MGSSQ DmelP007_AA -------------------------------------------------------MHISQ ScerP022_AA QTRLVPGSDSSSRPKKRRISKRSKI----------------------------------- DdisP001_AA SSIRESGIGGGG--------GGGGGGNDKDEMD---GSTAIPMEPMTSSSGVSSGGGGKV DmelP010_AA QVFLVAGTCLIT----VMVTLLCIG-------------------FMTRYEVENDVANVAD DmelP004_AA SRLFLISVVFSA----LLITAMCIG-------------------FVVHYGMSGDVGDMET DmelP001_AA MHCLVILGFLLG----SLVAFSWAG--------------VTTQPPPLIRTLSAGGDIGPQ NvecP001_AA RVDTLLVFAFCL----VVLTALCSG----------------------------------- HsapP002_AA SPFLVL---AIG----TCLTNSL------------------------------------- HsapP001_AA GPWVLL---LLG----LRLQLSLGV----------------------------------- HsapP003_AA GPCMLLLLLLLG----LRLQLSLGI----------------------------------- HsapP004_AA GPWVLL---LLG----LRLQLSLGI----------------------------------- SpurP004_AA DRFGEVGRNKGNRMKILLIIAVCMY----------------------------------- SpurP003_AA QRFIYL---TLN----SMVDCSNRS----------------------------------- SpurP001_AA MDFVIMEKATAF----ILLLLSLFQ----------------------------------- SpurP002_AA MEFTF----SVG----ILLLASL------------------------------------- DmelP003_AA RLLNALLIAIVLVAHPAWSAPECGR---------------TPEECREHRMHPDMPEPERH DmelP009_AA KFWIRLGLLTVVWG--AAVPGRAPV-----------------------DEERMHPHLPTS DmelP011_AA LRFFAALALQLT----ACSS-------------------------------QYKYGPEQS DmelP013_AA MRLQLFFFLGLS----VLVSGGESSHDAERRMHPVFSLMGTGSNPIGGGRYKRAMPQIVF DmelP002_AA KSCLILCFFAL-----LVIQARSDL--------------------ADDQEHAQHPRLQSS DmelP005_AA RRFILLLVLA------VCLSGSASG----------------------QRDHPRGRSFDAE DmelP012_AA LQLRRLAILFLLHALIPILALSVPM----------------------------------- DmelP008_AA KTFVAISLVLC-----TLVATSLAASIDMPEIHNQFQLVGGSVSTAKTREGNLIDPNAMA DmelP006_AA RQLVLPILLLLA----LAGTALCGV-----------QEVHNVLELTGQAANKLKFSTDVA DmelP007_AA RRCLYPIFLFLL----AFVGTALGR----------VQEVHNVLELTGQKASKLRFSTDVA ScerP022_AA ----IVSTVVCIG----------LLLVLVQLAFPSSFALR----SAS--HKKK--NVIFF DdisP001_AA VSHFLLEEDFDSKKRFTSTHKRIFYILTSLAILVTVVLLIVFLLPRGWEGPKKKTNIIMM DmelP010_AA VDYWKDKVATSQK----------IWYDKGIDELNEALRPQ-----DL--TYPK--NVRIF DmelP004_AA VSYWPVDLPKEQK----------EWYDQGIDELQKAVSRQ----FNR--RRAK--NVILF DmelP001_AA FDVGKTKEPEDAE----------FWHNVGLRQLEKTIKQAQRVKEDSYQKKAR--NIIIF NvecP001_AA ----DVPASQSNN----------QWFKDGVSTVKKHLLQR----PNT--KPAK--NLIIF HsapP002_AA ----VPEKEKDPK----------YWRDQAQETLKYALELQK---LNT--NVAK--NVIMF HsapP001_AA ----IPAEEENPA----------FWNRQAAEALDAAKKLQ----PIQ--KVAK--NLILF HsapP003_AA ----IPVEEENPD----------FWNREAAEALGAAKKLQ----PAQ--TAAK--NLIIF HsapP004_AA ----IPVEEENPD----------FWNRQAAEALGAAKKLQ----PAQ--TAAK--NLIIF SpurP004_AA ----VPVQGQSPD----------FWNSQARSSIEQALGLE----VNT--KPAK--NVIVF SpurP003_AA ----PSLTSSDAE----------FWNQEAQDSLKEAIRLTE---RNV--NTAK--NIVLF SpurP001_AA ----VLISAQEAP----------YWNLKGRAAVEEALLRQR---LNV--NIAK--NIIFF SpurP002_AA ----SLVNGQDAA----------FWNNQARDSIQKALERE----LNI--GEAK--NIIFF DmelP003_AA GKAFRVVDGEDTNA---------YWRQQGVQFVQQKLASE----PNK--RQAK--NVILF DmelP009_AA PRLRTISGEETQE----------FWHSASKKLIREKLEFV----RNT--KKAK--NIILF DmelP011_AA WDLDSISELKSKE----------FWFHDAQRTLYNKLSTP----PNQ--YRAK--NVIFF DmelP013_AA DA--VRSEERYAE----------YWQGLAAQTLDQQLESKLR--LNT--QLAR--NVMLF DmelP002_AA RDFEALDEELDTR----------FWHDKAQSILADKLAGHKK--LNE--NRAK--NVILF DmelP005_AA SHPIKYAEEQQTQ----------YWVDKAQAKLLSKLAEQES--ATT--NKAK--NVILF DmelP012_AA VEQVQPADELLSS----------HWLRQAQSQLRERLARTKDSIADV--RQAK--NVVML DmelP008_AA KGKPGPEEEKNAQ----------FWYDLAYEEIAKRLEQPQ---LDK--RKAK--NVILF DmelP006_AA TEKYTPPEEMDPQ----------YWYNIADEEITKRLQLPQ---PNS--QKAK--NIIMF DmelP007_AA TGKYTPPEEMDPQ----------FWYKLADEEIAKRLQLPQ---PNS--DRAK--NVIMF . . *: .: ScerP022_AA VTDGMGPASLSMARSFNQ--HVNDLPIDDILTLDEH-FIGSSRTRSSDSLVTDSAAGATA DdisP001_AA IGDGMGPAALTMARVCFH--TKGESTSQAHLHLDPY-IVGTVKTYSSNSVVTDSAAAATA DmelP010_AA VIQGIDGRDWAAFRFPTSDASRGN----TNFIWDRFPHLARLKNSCSQQFPCQVASVSRA DmelP004_AA VGDGMGPNTVTAARIL-------GVKEEGLLRWEQFPDMGLLKTYCADKQVPDSFSTATA DmelP001_AA IGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATA NvecP001_AA VGDGCDINTNTAGRILKGQ-LKGQVGEKGWLSYEEFPYTGLSKTYTTNRQGSDSAGTANA HsapP002_AA LGDGMGVSTVTAARILKGQ-LHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATA HsapP001_AA LGDGLGVPTVTATRILKGQ-KNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATA HsapP003_AA LGDGMGVSTVTAARILKGQ-KKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA HsapP004_AA LGDGMGVSTVTAARILKGQ-KKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATA SpurP004_AA VGDGMDVSTVVSSRIRQGQ-QAGVEGVSNVLAWDAFPHGGLVKTYSTDAQAADSASTSTA SpurP003_AA LGDGMSIETLTAARILKGQ-LAGGLGEDAKLAVEDFPHFGLAKTYSTNKQVPDSAATATA SpurP001_AA LGDGLDVTTTTAARIRKGQ-LAGGMGEEASLHFEHFPHVGLVKTYNTDRQVPDSAGTATA SpurP002_AA LGDGMSVPTVTAARIRQGQ-LKGETGEENILAWETFPHVGLIKTYNTDAQVPDSAGTATA DmelP003_AA LGDGMGVTTTSAARNLLG-------GEEKSLSFENFPFTGLSKTYSVDKIVPDSACTATA DmelP009_AA LGDGMGLATLAAARSYIG-------GEELKLSFEEFPFTGLSKTYSVDKIVPDSACTSTS DmelP011_AA LGDGMSVPTVTAGRIFDGQ-LRGVVGERNRLEFEKFNYVGLSKTYCVNKQVADSACTASA DmelP013_AA IGDGMSIPTITAGRVYLG-------GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATA DmelP002_AA LGDGMSVHTIAATRAFMG-------DSNKQVFFEKFPYLGLSKTYAVNERTPDSANTATA DmelP005_AA LGDGMSVHTVTATRNLLG-------DSAEQVYFEGFPYTGLSKTYCVNRQVADSACTATA DmelP012_AA LGDGLSITTLTAARILKGQ-RRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATA DmelP008_AA LGDGMSLSTVAAARIHKGQ-LKGNTGEEDSLSFEKFPYTGLSRTYCSNAQVPDSACTATA DmelP006_AA LGDGMPLSTVAAARILKGQ-RQGNTGEESSLSFERFPYTGLSRTYCSNAQVPDSACTATA DmelP007_AA LGDGMPISTVTAARILKGQ-RQGNTGEESSLSFEKFPYSGLSRTYCANAQVPDSACTATA : :* * . : . . .. : : : : ScerP022_AA FACALKSYNGAIGVDPH------------HRPCGTVLEAAKLAGYLTGLVVTTRITDATP DdisP001_AA YASGVKTYNNAVGVDAN------------GKPAGTIIEAAKKLGMKTGLVVTTRISDATP DmelP010_AA LWLGIPLD------KVPDNQQDCGRLFNATQGPISILRQAQLAGLRTGFVTTQRITG--P DmelP004_AA LFGGVKVNYETGGVDANVPLGNCSASLKEDHHVQTILKWAQVDGMRTGFVTTTRVTHATP DmelP001_AA IFSGSKTHYGAIGMDATRSKKNGQ-----QGRVQSVMEWAQKEGKRTGVVTTTRITHATP NvecP001_AA MFTGVKTRSAMIGVNEEVVTNKCETLTE-DRKVDSILKLAEEAGMATGFITSMRLTHATP HsapP002_AA YLCGVKANEGTVGVSAATERSRCNTTQ--GNEVTSILRWAKDAGKSVGIVTTTRVNHATP HsapP001_AA YLCGVKANFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKQAGKSVGVVTTTRVQHASP HsapP003_AA YLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKKAGKSVGVVTTTRVQHASP HsapP004_AA YLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKKAGKSVGVVTTTRVQHASP SpurP004_AA IFGGVKTKDGVLGLDDDAKRGDCASAT--GNEVASNLHLAHAEGKATGFVTSDSVTGATV SpurP003_AA YLCGVKTKTGVLGVDDRVERGDCVSSL--GGEVKSILEMAQEAGKSVGFVTTTTLTHASP SpurP001_AA YLCGVKSKFGTLGVDDRVERGKCTSIE--GAAVDSILIDSMKAGKSTGLVSTARVTHASP SpurP002_AA FFSGIKTKSGVVGIDDRVEYADCESGL--GGEVDSVLVNAHNIGKATGVISTARITHATP DmelP003_AA YLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIAKWAMEAGKWAGLVTTTRVTHASP DmelP009_AA YLCGVKANYGTIGVNAHVKRGDCAAMANETNHVFSLGKWAMDAGKAAGLVTTTRVTHASP DmelP011_AA YLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSIAAWALKGSKSAGLVTTTRVTHASP DmelP013_AA YLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASP DmelP002_AA YLTGVKANYGTIGVNAQVQRGDCVTNS--SSHVQSIGQWAQEAGKWAGLVTTARVTHASP DmelP005_AA YLGGVKANYGTIGVNANVSRYSCDGAANEEDRVLSIAHWAQAAGKDAGLVTTARVTHASP DmelP012_AA YFGGVKTHSGTVGQSGS------------GERVDSVLQWAQRAGKATGVVTTTRLTDASP DmelP008_AA YLCGVKTNIVALGITAAVSFNNCSGSEDPANQVDSIAAWAQAAGKATGIVTTTTLTHASP DmelP006_AA YLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVTTTTLTHASP DmelP007_AA YLCGVKTNIINIGVSAAVNFNNCTASQDPANRLTSIAEWAQNAGKSTGFVTTTTLTHASP . : : . .*.: : : ScerP022_AA ASFSSHVDYR-WQEDLIA-----------------THQLGE--YPLGRVVDLLMGGG--- DdisP001_AA ACYFAHSATR---HDEAF----------------IIDQLLD------KEIDVILGGG--- DmelP010_AA TGAALGNANGNFECDESMPLNSI-----KSGCQDIAQQLIS--DETGKFLNVLIGGG--- DmelP004_AA AALYAHVPDRRWECESGMPAEAQ-----GQGCMDIARQLIE--QPTGQSINVIMGGG--- DmelP001_AA AATYAHIYDRDWECDTEVPAESV------GFHVDIARQLVE--NAPGNRFNVILGGGMSP NvecP001_AA ANLYAHSASRYWESDKEMVSRGY---G-NTSCKDMAQQLVDFQGSVGDGIEVVMGGG--- HsapP002_AA SAAYAHSADRDWYSDNEMPPEAL-----SQGCKDIAYQLMH----NIRDIDVIMGGG--- HsapP001_AA AGTYAHTVNRNWYSDADMPASAR-----QEGCQDIATQLIS-----NMDIDVILGGG--- HsapP003_AA AGTYAHTVNRNWYSDADVPASAR-----QEGCQDIATQLIS-----NMDIDVILGGG--- HsapP004_AA AGAYAHTVNRNWYSDADVPASAR-----QEGCQDIATQLIS-----NMDIDVILGGG--- SpurP004_AA AALYAHSPERDWQSDADIPRK-------QEECNDLAYQLIM----ENDFINVILGGG--- SpurP003_AA GALYAKVPDRKWQSDMDIPRGER-----NLGCVDMAQQFVS-----NNNIQVALGGG--- SpurP001_AA AALYAHTPDRRWENDHDLDDRDK-----REGCKDIALQLIE----HGKNMNVIMGGG--- SpurP002_AA AATYAHVAKRDWEVDTEMIEDGED----GKGCKDIALQLIE----DNPFIKVILGGG--- DmelP003_AA SGVYAHIAERDWENDAEVATDCG---A-GSGINDIAYQLAR--GEVGSKLKVIMGGG--- DmelP009_AA SGVYAHVADREWENNAVLEEACG---ELSDGLQDIAVQLIH--GEVGSKLKVMLGGG--- DmelP011_AA AGVYAHTSNRDFESDYDVTKLGQ---N-PGNCPDIAQQLID--GDVGKRLRVVMGGG--- DmelP013_AA AGVYAHLANRNWENDAEVVGDNG---D-PDLCPDAAAQLIN--SPVGQKLNVIMGGG--- DmelP002_AA AGVYAHVSERNWEHDGEIISSKC---S-PDVNTDIARQLVE--WPVGQELRVIMGGG--- DmelP005_AA AGVYAHIADRNWENDWEVANREC---D-PEQTIDIARQLVE--QPVGQQLKVILGGG--- DmelP012_AA AGAYAHVSRR----GEEL---------------EIARQLVE--EEPGRNLNVILGGG--- DmelP008_AA SGAYAKTTNRFFESDTDILTYGEGQND-PATCTDIATQLIT--QAPGKNFDVMLGGG--- DmelP006_AA SGAYAKTANRMWECDTDVTSYGV---D-ANSCIDMATQLVT--QTPGKNFEVMFGGG--- DmelP007_AA SGAYAKTANRMWQSDTDVTSYGV---D-ASTCVDMATQLVT--QTPGKNFEVMFGGG--- *: . : :*** ScerP022_AA RSHFYPQGEKASPYGHH----GARKDGRDLIDEA--------QSNGWQYVGD----RKNF DdisP001_AA KQFFSNKTLQDAVS----------------------------SKYNYSYVES----KQEM DmelP010_AA -RQMLSSLVPNTKYDPVDEMLCESNDGRNLLKDWRNQKLK--ESKINRIIFDLIQRRDEL DmelP004_AA RQMLVSDVTGSAADPLDTWA-GQSKDGRDLIRDWRLKKAD--EGVSHAVVQN----NREL DmelP001_AA MGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHAN--DTVPPALVHN----RKDL NvecP001_AA RRSFLPNTTRDPEHVNKT---GERYDGRNLIQEW----LN--KREGSVYAWN----KTQF HsapP002_AA RKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTW-KSFKP--RYKHSHFIWN----RTEL HsapP001_AA RKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEW----LA--KHQGAWYVWN----RTEL HsapP003_AA RKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEW----LA--KRQGARYVWN----RTEL HsapP004_AA RKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEW----LA--KHQGARYVWN----RTEL SpurP004_AA RQEFLPTRVEDPEYYDVT---GRREDGNNLIGQW----QGEKEASSSHYVWN----KEDF SpurP003_AA RMKFMSRINRDPEYPSMP---GSRIDGRNLIQEW-INNKP--DQDRAHYVWN----EADF SpurP001_AA RRELTPRNVEDPEYDGDY---GQRLDGRNLIEDW----LEDKDPMRSHYVWN----LQDF SpurP002_AA RRMFYNNTELDPEDPSDR---GNRTDGRNLIEEW----QN--GKTNARYVWN----KEQF DmelP003_AA RKHFVDSSLESW---------GKRTDGLNLIDEF----KS--ASENNVYVTT----AAEL DmelP009_AA KRSFYS-----PEHYDK----GRRTDGRNLVEEF----EA--LDAGNTFVKT----QKKL DmelP011_AA TIKFLPNTTNDVFGNK-----GQRLDNRNLIEEW---QQT--KPGNARVVFS----RTDL DmelP013_AA RENFLPKGVTDSSGAP-----GRRLDGRNLIDEW---KNQ--HTNSAQYVEN----RREL DmelP002_AA RSYFRDQSQHDETGVS-----GLRTDGRDLISDWREIKKQ--QGAEGKYVWS----LKGL DmelP005_AA RKNFIDATVNDEEGYP-----GKRTDGRHLIRSWLDQKKE--ANVSAKYVWS----RKGL DmelP012_AA LGKFA----------------DERRDGKDLLAQW----RE--SNPNGCFSRS----LKEL DmelP008_AA IGKFLPNTITDPFNKK-----GERSDGVNLLSRW----QG--LHPGGVLAYN----RNQL DmelP006_AA MGKFLPNSIVDSHGNP-----GERSDGVNLLSRW----QG--LHDGGVLVTN----RNQL DmelP007_AA MGKFLPKTTKDSHGKY-----GERSDGVNLLSRW----QG--LHDKGVLVTN----RKQL : : ScerP022_AA DSLLKS-HGENVTLPFLGLFADNDIPFEIDR----DEKE---YPSLKEQVKVALGALEKA DdisP001_AA EQV----EAGR----ILGLFADYNIPWEIDRLR--DPTLLSTKPSLQEMTTKALNLISQ- DmelP010_AA ESLNSS-SFDY----LMGVMANGDLS---------GNSK---APSLKLMVDKSLNVLTK- DmelP004_AA WNLNGQ-DVDY----VLGIFANGHLMYDHERDR--SDAG---MPSLSNMTLKALEVLGN- DmelP001_AA LNVNVK-KVDH----LMGLFRNNHITYSIAR-----EAG---EPSLQEMTETALGILER- NvecP001_AA DAVDPK-TTKH----FLGMFESSHMQFAIDRDE--DVGG---EPSIAEMVEKAVSILKN- HsapP002_AA LTLDPH-NVDY----LLGLFEPGDMQYELNR----NNVT---DPSLSEMVVVAIQILRK- HsapP001_AA MQASLDQSVTH----LMGLFEPGDTKYEIHR----DPTL---DPSLMEMTEAALRLLSR- HsapP003_AA MQASLDPSVTH----LMGLFEPGDMKYEIHR----DSTL---DPSLMEMTEAALRLLSR- HsapP004_AA LQASLDPSVTH----LMGLFEPGDMKYEIHR----DSTL---DPSLMEMTEAALLLLSR- SpurP004_AA DNVEPT-TTDY----LLGLFEPGRMQYGADRAA--DGAG---EPSLAEMTEKAIKVLGR- SpurP003_AA NKIDPE-QTDY----LLGLFEYSLMKFDIRRDN--DTGG---EPSIAEMTDKAIRILSK- SpurP001_AA NRVNAE-TTDH----LIGLFQPSHMKYETDRRW--DRAG---EPSLAQMTEKAIKILQR- SpurP002_AA DAIDED-TTDY----LFGLFEDSHMRYASES----EEGN---DPSLASMTEKAIKMLQK- DmelP003_AA AAVDVT-KTDR----LLGLFNDDHLQYLMETT---TESS---QPTLEQMTRKAIEYMSQ- DmelP009_AA LNVNAT-ETGR----LLGLFSKSHMHYHLEQLAD-PDNN---EPTLEEMTQKAIEVLET- DmelP011_AA LNNDAQ-NTDF----LLGLFNASHLAYHMD-----DSID---TPTLPEMTAAAINVLSR- DmelP013_AA LNLS-N-HTSR----VLGLFAPYHMAYHLDA----SPAE---QPTLEEMVQSAMEILER- DmelP002_AA KETDIS-KTDY----LLGLFDTSHLPYHGDRRRTHYEDA---EPSLSDMTEAAIKMLSK- DmelP005_AA SLVDLE-NTDY----LLGLFANDHLPYNGDRDRKRSQLA---DPSLSELTEAAITVLSR- DmelP012_AA RNCT-D-ATGT----LLGIFSDSHMSYHLAA-----SKE---LPRLCDMAAAAIEKLER- DmelP008_AA LSVNVS-KITN----LIGTFRSGVMSFNKMA----DPKE---EPTLAEMTRKAIEVVSK- DmelP006_AA LKLNVS-AVSS----VIGLFQSKLMNFHLEA----DDTY---QPTLSELTEVTIKKLSQ- DmelP007_AA LNLDVS-AASS----IIGTFQSGLMDFHMDA----DPTY---QPTLSELTEVAIKKLSH- .:* : * : . :: : ScerP022_AA SNEDKDSNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAENSD--TETVL DdisP001_AA NNE----NGFFLMVEGSKIDVAAHINDAPTQIWETDAFDQTFNLVREWAEKD---GNTIV DmelP010_AA -YK----QGYLLIVE-QFIPSGIDKREQLQLLNDTL---------VNLHKD----QDTLT DmelP004_AA -SD----KGFLLVVEAGLIDQAHHRGNARKALSEVLELNAAVESTLSFLKSSDRLDETLV DmelP001_AA -GDES--NGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDP----DETLI NvecP001_AA -NDNG--KGFFLAVEAGLIDIGHHNGIARQALNEVVNLEEGVAKAVEMTDK----EDTLI HsapP002_AA -NP----KGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSS----EDTLT HsapP001_AA -NP----RGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSE----EDTLT HsapP003_AA -NP----RGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSE----EDTLS HsapP004_AA -NP----RGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSE----EDTLS SpurP004_AA -DE----DGFFLVVE---------------MLSNFV------------------------ SpurP003_AA -NP----NGFFLFVEGGRIDHGHHFGVANLALTETVAMDKAIDVALGLVDT----EETLV SpurP001_AA TSD----NGFFLFVEAGRIDHGHHDGMALDALTETLALDEAIGVALRLTSA----EDTLI SpurP002_AA -EE----KGFFLAVEGGRIDHAHHAGNAYNALGDAIAMSDAVAMALEMTSD----SDTLI DmelP003_AA -NE----QGYFLFIEGGRIDQAHHINQARMALNETIEFSKAIAAAQELTSE----DDTLL DmelP009_AA -EE----QGYFLFVEGGKIDISHHETMARIALDETAELSKAVKKAREMTNP----EETLI DmelP011_AA -DP----NGYFLFVEGGRIDHAHHETKAKKALDETVQFSDAVRKARQLTNP----WDTLI DmelP013_AA -QSAG--RGYFLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTST----DDTLI DmelP002_AA -NE----EGYFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDE----EDTLI DmelP005_AA -ND----KGFFLFVEGARIDMAHHDTFAKRSLEDTAEFARAVQKARELTSE----DDTLI DmelP012_AA -KSQEDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDP----RDTLV DmelP008_AA -RD----GGYFLFVEGGLIDYGNHFNSPTYSLSETLQFEQAVQEALDITDP----EETLI DmelP006_AA -NKE---HGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQLARDMTDI----EDTLI DmelP007_AA -NE----NGYFVFIEGGLIDYGNHYTQAGYALDEALEFEKAIQLAREMTNI----SDTLI *: :* : : ScerP022_AA VSTSDHETGGLVTSRQVT-ASYPQYVWYPQVLANATHSGEFLKRKLVDFVHEHKGASSKI DdisP001_AA IVTADHETGGLTLANQMVIDGNPKYSWSPE--------------TLLTVNKSADLMAELI DmelP010_AA LVLMTN-------------AIYPK--------------------PSLDVSEETETI---- DmelP004_AA IVTADH-------SHSLTINGHPDRGS-----------------SILGLAGNSKT----- DmelP001_AA LVTADH-------SHAVTFNGYALRGA-----------------DILGTANSHEKN---- NvecP001_AA ISTADH-------GHVFTLTGYPDINS-----------------PIFGLMKQDGEVKLAL HsapP002_AA VVTADH-------SHVFTFGGYTPRGN-----------------SIFGLAPMLSDT---- HsapP001_AA LVTADH-------SHVFSFGGYTLRGS-----------------SIFGLAPSKAQ----- HsapP003_AA LVTADH-------SHVFSFGGYPLRGS-----------------SIFGLAPGKAR----- HsapP004_AA LVTADH-------SHVFSFGGYPLRGS-----------------SIFGLAPGKAR----- SpurP004_AA -------------CHV-----------------------------TIGIVDDQESA---- SpurP003_AA MVTSDH-------AHTFKMAGYSARGN-----------------PILGKSDGRST----- SpurP001_AA VSTADH-------AHVMTMAGYASRGN-----------------PILGLEDHYLAD---- SpurP002_AA VVTADH-------AHTMSIGGYPDRGN-----------------KILGLAGYFGS----- DmelP003_AA VVTADH-------SHVFTYAGYSYRGS-----------------DVFGKTPVNGH----- DmelP009_AA VVTSDH-------SHTFSVSGYQPRGS-----------------DIFGAAKANGK----- DmelP011_AA VVSADH-------GHTVTISGYPDVNN-----------------SIVGLNSELSNV---- DmelP013_AA VVSSDH-------SHTMSLAGYSSRKN-----------------DIFGINDGQLAA---- DmelP002_AA VVTSDH-------SHTMSINGYPYRRQ-----------------NILSLAPNLAD----- DmelP005_AA VVTADH-------AHVMSINGYPYRDQ-----------------EITGLAQLAD------ DmelP012_AA VVTADH-------SHTLSMSGYAKRGT-----------------PILGMDAQQRDV---- DmelP008_AA VVTSDH-------AHPLTISGYPGRGT-----------------PILGLNQDDTDV---- DmelP006_AA VVTADH-------GHAVSIAGYPGRGT-----------------PILGINQHDTDI---- DmelP007_AA VVTADH-------GHAVSIAGYPGRGT-----------------PILGLNQHDTDI---- ScerP022_AA ENFIKHEILEKDLGIYDYTDSDLETLIHLDDNA-------NAIQDKLNDMVSFRA-QIGW DdisP001_AA KGGADPTKLIFDN-TGYTLTSDDLKEINRTKSA-------YYLNQVIGRIVSNYA-DIGF DmelP010_AA -SLLPEIF--------------------------------NEAES-EIQKRLHQ---MPS DmelP004_AA -EGTPYTTLTY--GTSYQGFQVDPQT-QSRKDP-------TADDI-TAWEYTQQA-AINT DmelP001_AA -DPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEER-AAPTYRHLA-TVPR NvecP001_AA NDNKPYTILGYMNGPGAVK--------GVRANL-------TGVDT-GAKDFKQQALYIGY HsapP002_AA -DKKPFTAILYGNGPGYKVVG------GERENV-------SMVDY-AHNNYQAQS-AVPL HsapP001_AA -DSKAYTSILYGNGPGYVFNS------GVRPDV-------NESES-GSPDYQQQA-AVPL HsapP003_AA -DRKAYTVLLYGNGPGYVLKD------GARPDV-------TESES-GSPEYRQQS-AVPL HsapP004_AA -DRKAYTVLLYGNGPGYVLKD------GARPDV-------TESES-GSPEYRQQS-AVPL SpurP004_AA -DRLPYTTLTYLNGPGGVNVQTNWANNGNRRDY-------SGVDT-ESRTWQQDA-IIPL SpurP003_AA -DLGSYTTVGYMNGPGAIISSLSYRLLGRRPPV-------TDANT-GRPFYLPQA-VVPT SpurP001_AA -DDLPYATLSYANGPGARHMASSFQKHGARENL-------TSVDT-EETGHRQQA-LVPF SpurP002_AA -DDLPFTTLGYLNGPGAEEVRQSYSDTGMRPNL-------TEIDT-EDKDYLQQA-IVPL DmelP003_AA -DGKPYMVLSYANGPSYENFYDAET--MERKDP-------TTVVK-GDHDDEFPS-GVPI DmelP009_AA -DGKPYLALSYANGKSFQDYYNTET--HERVDP-------TSLPTIGDFDQLFPA-MVPL DmelP011_AA -DQLPYTSISYANGPAYERFYKSTDGVVERVDL-------RNLDF-SKPDAIYPH-GVPM DmelP013_AA -DDLPYATLSYANGPGYDSNYLREGGAVRRKNL-------RAINM-KNKDFMFPS-TVPL DmelP002_AA -DELPFTILSYANGPGFDDTYSTK---DGRIDL-------SHADT-TSAEFEFQA-TVPL DmelP005_AA -DNLPYTILSYANGPGYYSGYNRA---EGRALL-------KEKLV-ADSDYQYPT-LAPL DmelP012_AA -NGVPYSTLNYAIGKWQSLDKD-----GRRESP-------SKTLS---PTSYTPS-YIHG DmelP008_AA -NGVKYATLNYAVGTNQYLDEH-----GQRIDL-------TDQI--GAEDFIHPS-YIHG DmelP006_AA -NGVQYSVLNYAAGPNQYLDEN-----GQRIPL-------DDIL--GSDDAITPS-YIPK DmelP007_AA -NGVKYSVLNYAAGPNQYLDEH-----GQRIPL-------DDIL--GPDDAISPS-YIDK ScerP022_AA T-THGHSAVDVNIYA-------YANKKAT---------------WSYVLNNLQGNHENTE DdisP001_AA T-TGGHTGEDVNLYT-------FGDTISEGKFETRLKDHQTEIVDNYIDPILRGNINNID DmelP010_AA E---------SLLFA-------QG----P---------------KSSI---FQGVRKETF DmelP004_AA D-ENLHGGSDVTIHA-------DG----A---------------MSYL---FHGVHEQSY DmelP001_AA K-DETHGGEDVAVFA-------YG----P---------------GSSL---IRGVFEQNY NvecP001_AA DYDEAHGSQDVGIYS-------RG----P---------------WAHL---LTGVVEQNV HsapP002_AA R-HETHGGEDVAVFS-------KG----P---------------MAHL---LHGVHEQNY HsapP001_AA S-SETHGGEDVAVFA-------RG----P---------------QAHL---VHGVQEQSF HsapP003_AA D-EETHAGEDVAVFA-------RG----P---------------QAHL---VHGVQEQTF HsapP004_AA D-GETHAGEDVAVFA-------RG----P---------------QAHL---VHGVQEQTF SpurP004_AA E-AETHGGADVPVYA-------QG----P---------------WSHM---FAGVHEQNY SpurP003_AA F-LETHGGDDVAIFA-------IG----P---------------MSHL---VHGVHEQNY SpurP001_AA D-EETHGGQDVMVYA-------RG----P---------------MAHL---FHGVQEQSY SpurP002_AA S-SESHGGDDVAIYA-------TG----P---------------MAHL---FHGVQEQSY DmelP003_AA D-MDSHGGDDVPVYA-------LG----P---------------WAHL---FTGVYEQST DmelP009_AA E-SETHGGEDVGVFA-------SG----P---------------WAHL---FTGVYEQNT DmelP011_AA T-EETHGGGDVAVYAHVVEYLLQG----P---------------WSHL---FTGVYEQST DmelP013_AA E-SETHGGDDVAVFA-------SG----P---------------YAQL---FTGVFEQHF DmelP002_AA S-SETHGAEDVGVFA-------SG----P---------------FEHL---FTGNYEQSA DmelP005_AA D-AETHGGDDVAVYA-------SG----P---------------YAQY---FSGNYEQSN DmelP012_AA R-KGVHSGEDVVVFA-------MG----P---------------QSHL---FGGVMEQNL DmelP008_AA T-IGVHAGDDVGIFA-------TG----P---------------QSHL---FTGVMQQST DmelP006_AA D-QGVHSGEDVGIFA-------SG----P---------------QSHL---FTGVMQQST DmelP007_AA E-IGVHSGEDVGIWA-------SG----P---------------QSHL---FTGVMQQST : : . . * :: ScerP022_AA VGQFLENFLEL-----------------------------NLNEVTDLIRDTKHTSDFDA DdisP001_AA IASFIIKTLNL-----------------------------DIQSITESLKDFIPKP---- DmelP010_AA LAHAISHVLSR-----------------------------SRVRP--------------- DmelP004_AA VAHAISYALRI-GRF-------------------------RDSSIAETLAELTPI----- DmelP001_AA LAYVMSYAGCL-GPAKDFDDSCEDH---------------KDGQKDRPLDKPNPKRNGAT NvecP001_AA IFHVMDHALCLSSSKQGTCS--------------------KPEARGGPSASAAMVTALFA HsapP002_AA VPHVMAYAACI-GANLGHC---------------------APASSAGSLAAGPLLLALAL HsapP001_AA VAHVMAFAACL-EPYTA-C---------------------DLAPPACTTDAAHPV----A HsapP003_AA IAHVMAFAACL-EPYTA-C---------------------DLAPPAGTTDAAHPGRSVVP HsapP004_AA IAHVMAFAACL-EPYTA-C---------------------DLAPRAGTTDAAHPGPSVVP SpurP004_AA IAHAVRHAACLDAAASSAC---------------------DLSATQDDVMEVRGARPAYQ SpurP003_AA VSHVMQRAACI-GYYADNC---------------------QPVQAAAGDDDFGTLSDATA SpurP001_AA IPHVIRYAACL-AGETEHCTNGQARWCEGGTASASSSSKTKEQAEVEAHVGASAVRRTHG SpurP002_AA IAHVMRNAGCYDETDTMNA---------------------CLNLNSASSNIPSALRVSLM DmelP003_AA IPHMMAYASCL-GDGHTMC---------------------K------------------- DmelP009_AA IPHMMAFAACV-GDGLTAC---------------------D------------------- DmelP011_AA LPHLMGFASCL-GPGITYC---------------------DLQPKARYSP---------- DmelP013_AA IPHALGYASCL--SDRNMC---------------------VDGGVARRPR---------- DmelP002_AA IPAMMAYAANI-GPFAK-----------------------DKINEQ-------------- DmelP005_AA IPALMARAAGI-GPYA-------------------------------------------- DmelP012_AA LPHIMGYAACL-GNGLTLC---------------------NQDKDADMIA---------- DmelP008_AA IPHLMAYASCI-GNGPTLC---------------------DNED---------------- DmelP006_AA IPHLMAYAACI-GSGKQVC---------------------DN------------------ DmelP007_AA IPHLMAYASCV-GSGKQVC---------------------GSSGRKT------------- : : ScerP022_AA TEIASEVQHYDEYYHELTN---- DdisP001_AA ----------------------- DmelP010_AA ----------------------- DmelP004_AA ----------------------- DmelP001_AA VVGASLIPILTAATAAILRGRGL NvecP001_AA PLVAALVTCLVLY---------- HsapP002_AA YPLSVLF---------------- HsapP001_AA ASLPLLAGTLLLLGASAAP---- HsapP003_AA ALLPLLAGTLLLLETATAP---- HsapP004_AA ALLPLLAGTLLLLGTATAP---- SpurP004_AA KR--------------------- SpurP003_AA LRVDAKLGILLVFSVLLALVKIA SpurP001_AA GMFQVIACAFLASCIRWMLQTTA SpurP002_AA ALLSAMITYFF------------ DmelP003_AA ----------------------- DmelP009_AA ----------------------- DmelP011_AA ----------------------- DmelP013_AA ----------------------- DmelP002_AA ----------------------- DmelP005_AA ----------------------- DmelP012_AA ----------------------- DmelP008_AA ----------------------- DmelP006_AA ----------------------- DmelP007_AA -----------------------