MUSCLE (3.8) multiple sequence alignment MIH1_ScerP029_AA ------------------------------------------------------------ CDC25-2_MbreP138_AA ------------------------------------------------------------ CDC25-1_MbreP137_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ cdc25_DdisP112_AA MGPTENQSFEIEFPNSSNTAAANSISTAINNNTTTAATITFTPANNNINNINNNNNNNNN twe_DmelP140_AA ------------------------------------------------------------ stg_DmelP139_AA ------------------------------------------------------------ CDC25_AqueP217_AA ------------------------------------------------------------ CDC25C_HsapP199_AA ------------------------------------------------------------ CDC25_NvecP153_AA ------------------------------------------------------------ CDC25_SpurP196_AA ------------------------------------------------------------ CDC25A_HsapP188_AA ------------------------------------------------------------ CDC25B_HsapP189_AA ------------------------------------------------------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ MIH1_ScerP029_AA ------------------------------------------------------------ CDC25-2_MbreP138_AA ------------------------------------------------------------ CDC25-1_MbreP137_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ cdc25_DdisP112_AA NKFNSNFDIESNKENSINQSNINSNVNSFPLKIQTKTLNSTTTSSNNNNNNIFSIGFRPL twe_DmelP140_AA ------------------------------------------------------------ stg_DmelP139_AA ------------------------------------------------------------ CDC25_AqueP217_AA ------------------------------------------------------------ CDC25C_HsapP199_AA ------------------------------------------------------------ CDC25_NvecP153_AA ---------------------------------------------QPSHLNLESQLHSGF CDC25_SpurP196_AA -----------------------------------------------------------M CDC25A_HsapP188_AA ------------------------------------------------------------ CDC25B_HsapP189_AA -----------------------------------------------------------M R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ MIH1_ScerP029_AA ----------------------------------------------MNNIFHGTEDECAN CDC25-2_MbreP138_AA ---------------------------------------------MSNSSMPSRLRRNSH CDC25-1_MbreP137_AA ---------------MAFSAPDLT----------------------TDVAGASNTAEEDA F16B4.8_CeleP059_AA -------MNRPSQISQDVAQPLSNQH--------------------ETAMMSSDEDSMSR ZK637.11_CeleP239_AA ----------------------MC----------------------VDVPCENCIVRNDG cdc25_DdisP112_AA SPRGVSPRFHSNSSSSCSSEISTPSSSTFLEDPNLIASNTISSNNSINNNNNNNNNNNNN twe_DmelP140_AA ---------------------------------------------MASKRLMLDVEEEDD stg_DmelP139_AA ------------MLWETIVEENNCS---------------------MDCNISNNTSSSSS CDC25_AqueP217_AA --------MSQRLVASMFSPVTF-----------------------DISPEEGNTVKRTP CDC25C_HsapP199_AA -----MEGAAPCRVSLKVSLGQRCWERAWRFDLGMGVVSSLTSHPLQNIAESGRPQLEAH CDC25_NvecP153_AA ISTGNTRNKKQKSSKAEFNMAGFCRQRADSFTLDFQNSSGDVAPNAVLSPITELSMNFEH CDC25_SpurP196_AA DELDIMERNKKKLTLPLSNDCVFSPCFSQT----------------QASPVTALSMSMVT CDC25A_HsapP188_AA MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAG---------GLSPVTNLTVTMDQ CDC25B_HsapP189_AA EVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHD R05H5.2_CeleP166_AA ----------------------------------------------MLKNVNNCLSKNDN K06A5.7_CeleP116_AA --------------MATTGEKAIY----------------------EDQNNVNIIENVVD MIH1_ScerP029_AA EDVLSFQKI-----------------------------SLKSPFGKKKNIFRNVQ----- CDC25-2_MbreP138_AA ATRAILND------------------------------ASNNSLKENSPSSSNSC----- CDC25-1_MbreP137_AA ANNICLT-------------------------------RLNQSPVSDSGIATSSP----- F16B4.8_CeleP059_AA DSGICELMDENTPV------------------------CFSSMSTESTTVQVEEC----- ZK637.11_CeleP239_AA LRLKCSEC---------------------------------------------------- cdc25_DdisP112_AA NNNNNNDNSNNNINTNNINNNNNNTNNGENPQKKQRNSQILSKNFYSLSLHADSPKHSRS twe_DmelP140_AA ESGACGQ-------------------------------ENFDPHDADMEYQAKRR----- stg_DmelP139_AA INKMSGSRRARRSL------------------------ELMSMDQEELSFYDDDV----- CDC25_AqueP217_AA RRKLCLDD------------------------------SIHSPTTTDSACSTSCS----- CDC25C_HsapP199_AA LETRGGGHVGRRFCFSPGENSKTMS-------------TELFSSTREEGSSGSGP----- CDC25_NvecP153_AA NSISMGKTPKRKLSLSNCDNASPSP-------------CFLRTMSNESGYCPDSP----- CDC25_SpurP196_AA LSCMGGTPKRRLSMSSIGEASPVPP-------------NLSRHSSHSSGVSVGTP----- CDC25A_HsapP188_AA LQGLGSDYEQPLEVKNNSNLQ-----------------RMGSSESTDSGFCLDSP----- CDC25B_HsapP189_AA LAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSP----- R05H5.2_CeleP166_AA LQGIRLDS---------------------------------------------------- K06A5.7_CeleP116_AA VANGINESPKTL--------------------------FEEDGSSRDSGVSMTSC----- MIH1_ScerP029_AA ------------------------------------------------------------ CDC25-2_MbreP138_AA ------------------------------------------------------------ CDC25-1_MbreP137_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ cdc25_DdisP112_AA TTDLSTFLGMSDPDVMTYRSKTFCISDFHQFDIDTTTNDNKNKNNNTKSTDESSTFDGKS twe_DmelP140_AA ------------------------------------------------------------ stg_DmelP139_AA ------------------------------------------------------------ CDC25_AqueP217_AA ------------------------------------------------------------ CDC25C_HsapP199_AA ------------------------------------------------------------ CDC25_NvecP153_AA ------------------------------------------------------------ CDC25_SpurP196_AA ------------------------------------------------------------ CDC25A_HsapP188_AA ------------------------------------------------------------ CDC25B_HsapP189_AA ------------------------------------------------------------ R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA ------------------------------------------------------------ MIH1_ScerP029_AA --------------------------------TFFKSKSK-------------------- CDC25-2_MbreP138_AA --------------------------------GERDCSSPSMPREHRQNGRKLISKKSSR CDC25-1_MbreP137_AA --------------------------------SSPLFDHNLSLHDNIRYTQSALATR--- F16B4.8_CeleP059_AA --------------------------------MEIDEDENLQPG---------------- ZK637.11_CeleP239_AA ------------------------------------------------------------ cdc25_DdisP112_AA SNSVENNNMTIINNNNNNNNNNNNNNNNNNNNNNLNQDRPTIPTVAHSLSSNSIPHKFNS twe_DmelP140_AA --------------------------------KSAVQETPLQWMLKR------------- stg_DmelP139_AA --------------------------------VPQDQ----------------------- CDC25_AqueP217_AA --------------------------------MNSDSECST------------------- CDC25C_HsapP199_AA --------------------------------SFRSNQRKMLNLLLERDTSFTVCPDVPR CDC25_NvecP153_AA --------------------------------MWPSCESPTIELLRSTADMKKSFHLRRP CDC25_SpurP196_AA ----------------------------------SPCESPLILGTFQPINPSNDQPESSR CDC25A_HsapP188_AA --------------------------------GPLDSKENLENPMRRIHSLPQKLLGCSP CDC25B_HsapP189_AA --------------------------------SPMDPHMAEQTFEQAIQAASRIIRNEQF R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA --------------------------------SDKSDASPEEDVDFSKLESGRVALTDCS MIH1_ScerP029_AA -------------------------------------------HSNVDDDLINKENLA-- CDC25-2_MbreP138_AA S------------------------------------------SRNSASEPYSSGSPR-- CDC25-1_MbreP137_AA -------------------------------------------PGPSDSPTLNFNDLN-- F16B4.8_CeleP059_AA -------------------------------------------PVSRRQKKVTFRREK-- ZK637.11_CeleP239_AA ------------------------------------------------------------ cdc25_DdisP112_AA SNSLPPQMLSSSAPSLFSLLENSNNNNNNNNNNNNNNNNNNNNNNNNDNSNISINDESIV twe_DmelP140_AA -------------------------------------------HIPASTTVLSPITEL-- stg_DmelP139_AA -------------------------------------------QRSASPELMGLLSPE-- CDC25_AqueP217_AA -------------------------------------------SIDRRHSLATYPGKE-- CDC25C_HsapP199_AA TPVGKFL------------------------------------GDSANLSILSGGTPK-- CDC25_NvecP153_AA SFRRWNSSP----------------------------------AGCDESDKENINSPL-- CDC25_SpurP196_AA HSTQFRRFNSMPLRLQQ--------------------------QHQESPSLQMFHRPR-- CDC25A_HsapP188_AA ALKRSH-------------------------------------SDSLDHDIFQLIDPD-- CDC25B_HsapP189_AA AIRRFQSMPVRLLG-----------------------------HSPVLRNITNSQAPD-- R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA NFVSILQRNSSV-------------------------------SSSRSSSFYNYDTPT-- MIH1_ScerP029_AA ------------------------------------------------------------ CDC25-2_MbreP138_AA ------------------------------------------------TTTWVHSRCSAA CDC25-1_MbreP137_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ----------------------------------------------------------SS ZK637.11_CeleP239_AA ------------------------------------------------------------ cdc25_DdisP112_AA LISTPVKEYSYNRSLCLSDEEGGEDDEDDTPPTPIQLVRPTPTPINPSLSLSLSSSLNAT twe_DmelP140_AA ------------------------------------------------------------ stg_DmelP139_AA ------------------------------------------------------------ CDC25_AqueP217_AA ---------------------------------------------------NVCSGPLSG CDC25C_HsapP199_AA ------------------------RCLDLSNLSSGEITATQLTTS-ADLDETGHLDSSGL CDC25_NvecP153_AA ---------------------------------------------VLQLDGCEGEGEADQ CDC25_SpurP196_AA --------------------LIRQHGLEEPMKEEEKEDGLWMMKPAGKRKDSEEENEEEK CDC25A_HsapP188_AA ----------------------------ENKENEAFEFKKPVRP--VSRGCLHSHGLQEG CDC25B_HsapP189_AA ------------GRRKSEAGSGAASSSGEDKENDGFVFKMPWKPT-HPSSTHALAEWASR R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA -----------------------------------------------------GRKMKTV MIH1_ScerP029_AA -------FDKSP-----------------------------------------LLTNHRS CDC25-2_MbreP138_AA SSCSELSPCSSP-----------------------------------------VLFASHN CDC25-1_MbreP137_AA -LSSPAKRGNGS-----------------------------------------AVESPQP F16B4.8_CeleP059_AA CQVRLFDESPTS-----------------------------------------HKMFMRP ZK637.11_CeleP239_AA --------AEGS-----------------------------------------SKLFPRQ cdc25_DdisP112_AA NSTTYLHLGRSATVLLNPPLLVSSMRQHHNSPSSSPSQSIPIVQTRERSQSSLSFLSPYQ twe_DmelP140_AA ----SQNMNGAR-----------------------------------------LDGTPKS stg_DmelP139_AA --------GSPQ-----------------------------------------RFQIVRQ CDC25_AqueP217_AA AKLRPLSFSSLP-----------------------------------------LSPLSSN CDC25C_HsapP199_AA QEVHLAGMNHDQ-----------------------------------------HLMKCSP CDC25_NvecP153_AA KEEFVFARPRVP-----------------------------------------SFVRRFS CDC25_SpurP196_AA ADSMQLDLPSPD-----------------------------IVEEATLPSEGFTFVMPKP CDC25A_HsapP188_AA KDLFTQRQNSAP-----------------------------------------ARMLSSN CDC25B_HsapP189_AA REAFAQRPSSAP-----------------------------------------DLMCLSP R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA FDLDSLDHSEYE-----------------------------------------KRVMSER MIH1_ScerP029_AA KEIDGPSPNIK----------------QLGHRDEL--------------------DENEN CDC25-2_MbreP138_AA EQLRPASRTHILPNHTDEALSAEFGGVQLGSQSVIDVLEDDDDDGDAVFETCPWLKGNSI CDC25-1_MbreP137_AA PKMICRSRSVG----------------DLFSKRT-------------------------- F16B4.8_CeleP059_AA QAPLSVRSENQ----------------QLLQQRKRKFE-----------------KSEQS ZK637.11_CeleP239_AA NRQHSSAISHI----------------SNSSPPT---------------------RKRSI cdc25_DdisP112_AA QQYYPSSPELS----------------PMVPTPLVNRIFNNINNNNNNNNNNNNNNNNNN twe_DmelP140_AA TQRIPANRTLNNF--------------NSLSSRTLGSFSSSCSSYE---------SGNSL stg_DmelP139_AA PKILPAMGVSS----------------DHTPARSFRIFNSLSSTCS---------MESSM CDC25_AqueP217_AA RNNVLTSKPLM----------------KHISSPL----ERMTLASP---------NSCSS CDC25C_HsapP199_AA AQLLCSTPNGL----------------DRGHRKR----DAMCSSSA---------NKEND CDC25_NvecP153_AA KGRLPPQRSLS----------------DPLSEQVSPARSDSVDSGAGDMDID---DVEAG CDC25_SpurP196_AA LSARPASSRVSSLNFAPAGSRPISAPATLLDEEEDDDAIQLQEDRLTSFHDDED-DDADN CDC25A_HsapP188_AA ERDSSEPGNFI----------------PLFTPQS--------PVTA---------TLSDE CDC25B_HsapP189_AA DRKMEVEELS-----------------PLALGRF------SLTPAE---------GDTEE R05H5.2_CeleP166_AA ---------------------------RLSVEQI-------------------------- K06A5.7_CeleP116_AA PTDNHRKRTSS----------------SMSPSVT-------------------------- MIH1_ScerP029_AA ENDDIVLSMHFASQTLQSP----------------------------------------- CDC25-2_MbreP138_AA EDHYEAM-------EFDND----------------------------------------- CDC25-1_MbreP137_AA ---FSER-------LSASC----------------------------------------- F16B4.8_CeleP059_AA SDHFHLE-------PMSVE----------------------------------------- ZK637.11_CeleP239_AA DGGY----------TSGTD----------------------------------------- cdc25_DdisP112_AA NNNNNNNNNNNNNGTNSNNLNNQSTSEDRDDSPNTSLDQISGSPYKTPSKLSFHSPNSSA twe_DmelP140_AA DDEYMDM--------FEME----------------------------------------- stg_DmelP139_AA DDEYMEL-------FEMES----------------------------------------- CDC25_AqueP217_AA DGYFSDV-------FDCVG----------------------------------------- CDC25C_HsapP199_AA NGNLVDSEMKYLGSPITTV----------------------------------------- CDC25_NvecP153_AA DDGFIDD---------LVN----------------------------------------- CDC25_SpurP196_AA DDGFSDI--------FDTD----------------------------------------- CDC25A_HsapP188_AA DDGFVDL---------LDG----------------------------------------- CDC25B_HsapP189_AA DDGFVDI----------LE----------------------------------------- R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA --------------LLDRK----------------------------------------- MIH1_ScerP029_AA -----------------------------TRNSSRRSLTNNRDNDLLSRIKYPGSPQRSS CDC25-2_MbreP138_AA -----------------------------ILEELCVPTPDRSDGSSRFPISKLSNLGASS CDC25-1_MbreP137_AA -----------------------------SRQASASNSPTRFHSTPC------------- F16B4.8_CeleP059_AA -----------------------------AMDDDEIVMMDQNTTKW-------------- ZK637.11_CeleP239_AA -----------------------------SANTSEIVIKKRLT----------------- cdc25_DdisP112_AA IFNSISNSQQTGKRSRTCLDFTKFSSHLLDEDSSCFSTQTNNNNTSSTGLISPSSSPKQQ twe_DmelP140_AA -----------------------------SAENHNLELPDDLEVLLSGQLKSESNLEEMS stg_DmelP139_AA -----------------------------QSQQTALGFPSGLNSLISGQIKEQPAAKSPA CDC25_AqueP217_AA ------------------------------EDPSQEMMPKCFSSLFAAPISSNCDDDRES CDC25C_HsapP199_AA -----------------------------PKLDKNPNLGEDQAEEISDELMEFSLKDQEA CDC25_NvecP153_AA -----------------------------SQEEKDMNMPQGMANLLSAPLVSSNCSPVTG CDC25_SpurP196_AA -----------------------------SQEGSSSAFSDGLAGLIHGALISPAGKAINS CDC25A_HsapP188_AA -----------------------------ENLKNEEETPSCMASLWTAPLVMRTTNL--- CDC25B_HsapP189_AA -----------------------------SDLKDDDAVPPGMESLISAPLVKTLEKEEEK R05H5.2_CeleP166_AA -----------------------------PREDTAVKTP--------------------- K06A5.7_CeleP116_AA -----------------------------RSRNLSLVAPQSDKSCRYNGLNNPRDDPFG- MIH1_ScerP029_AA SF---------------------------------SRSRSLSRKPSMNSSSN-------- CDC25-2_MbreP138_AA LNQSFPPANMTRQAAATASPQLTASRQIKPSNTAFRATCAQGQLAGSPLLLP-------A CDC25-1_MbreP137_AA ------------------------------------------------------------ F16B4.8_CeleP059_AA ------------------------------------------------------------ ZK637.11_CeleP239_AA ------------------------------------------------------------ cdc25_DdisP112_AA NVLIENTTNTTSNSSSSSSSTTTTTTTISVTNTLAAIQQNLNSNANLNNNNNNNNNNNNN twe_DmelP140_AA NKKGS------------------------------LRRCLSMYPSEQPEEAV-------- stg_DmelP139_AA GLSMRRPS---------------------------VRRCLSMTESNTNSTTTPPPKTPET CDC25_AqueP217_AA P----------------------------------VSRRGSMKRSLLETNDE-----RES CDC25C_HsapP199_AA K----------------------------------VSRSGLYRSPSMPENLN-------- CDC25_NvecP153_AA TSSFTLLKEDTPKQINAE-----------------ARPRDLFNTAGDKEKTR-----PRS CDC25_SpurP196_AA PPSHSIASESSQSGNIPNRGVDCNTLRTTPSGGP-RCRKGIFKIPSQPVLAR-------R CDC25A_HsapP188_AA -----------------------------------DNRCKLFDSPSLCSSST-------- CDC25B_HsapP189_AA DLVMY------------------------------SKCQRLFRSPSMPCSVI-------- R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA -----------------------------------DEDDEVFEQSNVRNSQV-------Q MIH1_ScerP029_AA ----SSRRVQRQDGKIPRS-------SRK------------------SSQKFSNITQNTL CDC25-2_MbreP138_AA ASQPSASPARQIAENPGRP-------APRRAVTLQRSQ---------SESAASRRPVPDL CDC25-1_MbreP137_AA -SSPLPTPTHPVSCTYPIR-------NQRRP----------------------------- F16B4.8_CeleP059_AA -EPGFRAPNHKKGR---------------------------------------------- ZK637.11_CeleP239_AA ----FSKKSHSTSE---------------------------------------------- cdc25_DdisP112_AA ISSYFSRSNSISSQRPPRPLSMSSSFISRQSPDIHISSNSLPKPVDTSNTNNNNENENDT twe_DmelP140_AA -------QEPDQETNMPMK-------KMQRK----------------------------- stg_DmelP139_AA ARDCFKRPEPPASANCSPI-------QSKRHRCAAVEKENCPAPSPLSQVTISHPPPLRK CDC25_AqueP217_AA KKTPLPSPSSFTALQPPSS-------PPAAHK---------------SLKGVALFRSQSV CDC25C_HsapP199_AA -RPRLKQVEKFKDNTIPDK-------VKKKY----------------FSGQGKLRKGLCL CDC25_NvecP153_AA KSFALKRPNPPRDPNPMEK-------KRLRQRCMSLVESNS------GLSPALLTRPGNL CDC25_SpurP196_AA NSSFLKRTERPQDTPSPVQ-------NKRPRSSSVASPQVTSM----EAEKTSPKNRMCL CDC25A_HsapP188_AA -RSVLKRPERSQEESPPGS-------TKRRKSMSGASP---------KESTNPEKAHETL CDC25B_HsapP189_AA -RPILKRLERPQDRDTPVQ-------NKRRRSV--------------TPPEEQQEAEEPK R05H5.2_CeleP166_AA ------------------------------------------------------------ K06A5.7_CeleP116_AA NTSIFAQPAPRTATSLWDL----------------------------APPMFFERKTSDT MIH1_ScerP029_AA NFTSASSSPLAPNSVGVKCFE----------SCL-----------AKTQIPYYYD--DRN CDC25-2_MbreP138_AA VPSSSEDRKSVPLSRDVRSEADVCSPLPKLQSAMQSDHD------YEYPLPLTDT--RHC CDC25-1_MbreP137_AA ---SGTLRRPSPTPASAQRTS----------SPLHIVMD------EQNVLPTVRV--EHN F16B4.8_CeleP059_AA ---LTRSATAFPSLETFEEEE----------HEEQHHLN------VKYHLKTVAK--ESS ZK637.11_CeleP239_AA ----------------IETWN----------AHLQVDYH------LETVTPSCST--VYQ cdc25_DdisP112_AA NKLDKINNVNSNIAKIIEQQQQRNISNSNNNNNLTQDQDQQDDQFKAKLLKQLSG--RQG twe_DmelP140_AA -----TLSMNDAEIMRALGDE----------PELIGDLS------KPCTLPCLATGIRHR stg_DmelP139_AA CMSLNDAEIMSALARSENRNE----------PELIGDFS------KAYALPLMEG--RHR CDC25_AqueP217_AA CVPPPCEDAMFPDSPGSGGVE------------RIGDHT------KPYLLPLTQG--TVP CDC25C_HsapP199_AA KKTVSLCDITITQMLEEDSNQ----------GHLIGDFS------KVCALPTVSG--KHQ CDC25_NvecP153_AA LKRSPFQRSNSEVFENRPNWQIGTFLGTESNRNLIGDFS------KTYVLPSITG--QHE CDC25_SpurP196_AA GRSLSMLSPNDPYFRRIDQAL----SIEGGQHNLTGDRT------KACSVPLVTG--KQK CDC25A_HsapP188_AA HQSLSLASSPKGTIENILDND---------PRDLIGDFS------KGYLFHTVAG--KHQ CDC25B_HsapP189_AA ARVLRSKSLCHDEIENLLDSD---------HRELIGDYS------KAFLLQTVDG--KHQ R05H5.2_CeleP166_AA --------------------------------------V------VRYCLPTVES--PQR K06A5.7_CeleP116_AA SGNGSFQERPKQILRAMSVGE--------IDSELPPTLE------VKYTLPGVDN--PQR MIH1_ScerP029_AA SNDFFP-RISPETLKNILQNNMCESFYNS--CRIIDCRFEYEYTGGHIINSVNIH---SR CDC25-2_MbreP138_AA KRKYIRAYISGETLSRLLKGEYAEHFT-H--VLVLDCRFSFEYDGGHILNAQRAW---LR CDC25-1_MbreP137_AA Q-------VTGDTVIDTVWGDGRRKFR-D--YIIIDARYPYEYDGGHLIGAVNFY---LP F16B4.8_CeleP059_AA KG--FR-RITAETLRDIFFRLSEKEFDDK--YILIDCRYPYEYNRGHIKNAINHF---DR ZK637.11_CeleP239_AA K-------ITSETLIEIMQKLSQIEFMQK--YILIDCRYDYEYNGGHIKGAQSLF---NP cdc25_DdisP112_AA ----YN-GVSSESVYELLKNPTLINAIIT----VVDCRYKYEYDGGHIKNAINIPPTGSR twe_DmelP140_AA D---LK-TISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLY---TR stg_DmelP139_AA D---LK-SISSETVARLLKGEFSDKVA-S--YRIIDCRYPYEFEGGHIEGAKNLY---TT CDC25_AqueP217_AA D---QK-SISPDTVESLLNGKHDT----K--YLIVDCRYPYEYEGGHIRGAINIW---EK CDC25C_HsapP199_AA D---LK-YVNPETVAALLSGKFQGLIE-K--FYVIDCRYPYEYLGGHIQGALNLY---SQ CDC25_NvecP153_AA D---LK-CISPETVTKLINGDYKDEID-E--YYIIDCRYPFEFDGGHVKGAINIY---TK CDC25_SpurP196_AA D---LK-CISPETMCRLLRSEYDQEIA-E--CHVIDCRYPYEFNGGHIKGAINIY---EE CDC25A_HsapP188_AA D---LK-YISPEIMASVLNGKFANLIK-E--FVIIDCRYPYEYEGGHIKGAVNLH---ME CDC25B_HsapP189_AA D---LK-YISPETMVALLTGKFSNIVD-K--FVIVDCRYPYEYEGGHIKTAVNLP---LE R05H5.2_CeleP166_AA ESSSFR-SISATVFASLLRDRSRCL---Q--LIIFDCRYPFEYFGGHIKGAVNIY---SL K06A5.7_CeleP116_AA ESQAFR-SISPTTLL-LEFQRLGDDFDKK--YIIVDCRFPFEYKGGHVKGAINLF---RH :. . :.*.*: :*: **: : MIH1_ScerP029_AA DELEYEFIHKVLHS----DTSNNNTLPTLLIIHCEFSSHRGPSLASHLRNCDRIINQDHY CDC25-2_MbreP138_AA EHVLNHLFYNPQVP-------FTETHRTAVVFHCEFSAQRGPDQYEFARCLDDIFSHGTG CDC25-1_MbreP137_AA DMAAEYLLARGDLS------------QTLILVHCEFSKERGPALYHYLKRVEAKACKNGG F16B4.8_CeleP059_AA VTVSKIFYDENGRK----------RCNKIPIFYCEFSQARGPKMAYALRQVDRELNVNHY ZK637.11_CeleP239_AA ETAADFFFNKDGSK----------KINRIPIFYCEYSQKRGPTMANNLREVDRKLNSNIY cdc25_DdisP112_AA QMVLDRFFKFPTPK----------NQQHVIIFHCEFSSKRAPDCYSLFRELDREHN--EY twe_DmelP140_AA GQIQEAFPTLTSNQ----------ENRRIYVFHCEFSSERGPKLLRYLRSNDRSQHTHNY stg_DmelP139_AA EQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSERGPKMSRFLRNLDRERNTNAY CDC25_AqueP217_AA DTLLERFFSTPTHP----KSSSESEERNIIVFHCEFSSKRAPEMSRFMRKVDRERNGMEF CDC25C_HsapP199_AA EELFNFFLKKPIVP-------LDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLN--QY CDC25_NvecP153_AA DEMLKQFIDTPKCK---------EGKRVVVIFHCEFSSKRGPDMCRFLRNRDRDIHRPSY CDC25_SpurP196_AA AELKKMFLENPLPP-------LPNNGRRVYVFHCEFSSQRGPKMLRLLRAQDRSANLENY CDC25A_HsapP188_AA EEVEDFLLKKPIVP--------TDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGN--EY CDC25B_HsapP189_AA RDAESFLLKSPIAP-------CSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVN--DY R05H5.2_CeleP166_AA DELGKYLYDEYGVK--------STLGGLIPIFYCEYSQVRGPAMARRLRKIDTHRNNHRA K06A5.7_CeleP116_AA DKIKPIFFPENGEA--------SSFQNRVPIFYCEYSQKRGPTMAHAVRSIDRVLNELRY : :.:**:* *.* . : MIH1_ScerP029_AA PKLFYPDILILDGGYKAVFD-----N--FP-ELCYPRQYVGMNSQENLLNCEQEMDKFRR CDC25-2_MbreP138_AA QRLW-PNMFILEKGYREFYK---NYPEHCFGKYCEMKDTTKASDLAH----DEQILECSR CDC25-1_MbreP137_AA QGSLFPHLYVLHQGYKQFHA-----E--HP-TYCSPRGYVPMTTAAH----KSECQACEK F16B4.8_CeleP059_AA PKCDYEEMYVLDLGYRNFFF---AANEANITNLCQPHAYCEMHDKEH----TMELKKYNF ZK637.11_CeleP239_AA PRCDYEEIYLLEGGYKNFYAFTRGLEKEQRVQLCEPDNYVIMFDDRY----KAELRKHQF cdc25_DdisP112_AA PNIHYPEIYLLNGGYKKFFE-----S--FQGDMCEGN-YIRMDDKLY----QANLKEEEE twe_DmelP140_AA PALDYPELYILHNGYKEFFG-----L--YS-QLCQPSQYVPMLAPAH----NDEFRYFRA stg_DmelP139_AA PALHYPEIYLLHNGYKEFFE-----S--HV-ELCEPHAYRTMLDPAY----NEAYRHFRA CDC25_AqueP217_AA PKLYYPELYLIEGGYKNFYA-----T--HP-DLCEPKEYKTMLDTGH----KVDLMHFSR CDC25C_HsapP199_AA PALYYPELYILKGGYRDFFP-----E--YM-ELCEPQSYCPMHHQDH----KTELLRCRS CDC25_NvecP153_AA PSLFYPELYLLDGGYKNFFN-----T--CK-EHCEPQNYVLMLDENY----SNDLKLFSK CDC25_SpurP196_AA PALYYPELYLLNEGYKAFFE-----Y--ST-EFCEPKIYTPMNHDDH----LEDLRYFRA CDC25A_HsapP188_AA PKLHYPELYVLKGGYKEFFM-----K--CQ-SYCEPPSYRPMHHEDF----KEDLKKFRT CDC25B_HsapP189_AA PSLYYPEMYILKGGYKEFFP-----Q--HP-NFCEPQDYRPMNHEAF----KDELKTFRL R05H5.2_CeleP166_AA AALDFPEIYLLDKGYVNFWS-----DVSLR-DLCEPRYYISMHARPF----RHALQQYTQ K06A5.7_CeleP116_AA PHVEYPEMYLLDYGYKSLWS-----TAECR-QICEPCSYIPMTHSSF----SMEFKSARL : :: ** . * MIH1_ScerP029_AA ESK-----RFATKNNSFRKLASPSNPNFFYRDSHQSSTTMASSALSFRFEPPPKLSLN-- CDC25-2_MbreP138_AA LSV-----------QDAEK----------------------------------------- CDC25-1_MbreP137_AA KRQ--------------------------------------------------------- F16B4.8_CeleP059_AA HNKGQSVLRTVSMSRSFKSLPTGSAFNFVA------------------------------ ZK637.11_CeleP239_AA HKK--------NVSKPMKK----------------------------------------- cdc25_DdisP112_AA -KK--------------KK----------------------------------------- twe_DmelP140_AA -KT--------------KS----------------------------------------- stg_DmelP139_AA -KS--------------KS----------------------------------------- CDC25_AqueP217_AA -RS--------------KS----------------------------------------- CDC25C_HsapP199_AA QSK--------------------------------------------------------- CDC25_NvecP153_AA -RS--------------KS----------------------------------------- CDC25_SpurP196_AA -KS--------------KS----------------------------------------- CDC25A_HsapP188_AA -KS--------------RT----------------------------------------- CDC25B_HsapP189_AA -KT--------------RS----------------------------------------- R05H5.2_CeleP166_AA HRSKSTANDTKHKKTHMRI----------------------------------------- K06A5.7_CeleP116_AA ERHHSMASLKPNGETSHREEKKKRCTRSVIRRNNSSLNMLSRSSSALTSTGSKTSSMENI MIH1_ScerP029_AA -HRRVSSGSSLNSSESTGDE----NFFPILSKSSMSSNSNLSTSHMLLMDGLDTPSYFSF CDC25-2_MbreP138_AA -----------LEEDHAAFF----EMRKQFVKGGRSALTNPRRMVQGGE----------- CDC25-1_MbreP137_AA ------------------------QVADSTIRRTRKRDSAIS------------------ F16B4.8_CeleP059_AA -----------SSASFTSAPSTSTENIDTNDDCQKSRTPAVPRIASRRNL---------- ZK637.11_CeleP239_AA -----------WSSTTSVIS----ILTTSGTRISTLRQ---------------------- cdc25_DdisP112_AA -----------EK---------------ITIRNIKA------------------------ twe_DmelP140_AA -----------WQCGEGGDS----GIGGGGSRGLRK------------------------ stg_DmelP139_AA -----------WN-----------GDGLGGATGRLKK----------------------- CDC25_AqueP217_AA -----------WA-------------GHSNVKGSRLR----------------------- CDC25C_HsapP199_AA --------------------------VQEGERQLREQ----------------------- CDC25_NvecP153_AA -----------WS----------------EGQGKKS------------------------ CDC25_SpurP196_AA -----------WT-----------------ERSRLV------------------------ CDC25A_HsapP188_AA -----------WA----------------GEKSKRE------------------------ CDC25B_HsapP189_AA -----------WA----------------GERSRRE------------------------ R05H5.2_CeleP166_AA -----------FSSEHLLDEPKMIDVPSGYERPTGAEETSTPRQPRART----------- K06A5.7_CeleP116_AA LYGLDDERRPKWVSAFDIQSTESENDLDAALIYQRNISSNASNASSIVNLAEERIVQLGL MIH1_ScerP029_AA EDERGNHQQVSGDEEQDGDFTFVGSDREDLPRPARRSLFPSLETEDKK CDC25-2_MbreP138_AA --------PMTPVHQITKYR---------------------------- CDC25-1_MbreP137_AA --------INEGEVCHFRF----------------------------- F16B4.8_CeleP059_AA --------FSDPSHSPTNFAQFPLTCSRETPSPHKHPLTCPRFS---- ZK637.11_CeleP239_AA --------TCDPIHEHDAH----------------------------- cdc25_DdisP112_AA --------FKNRSHSFHV------------------------------ twe_DmelP140_AA --------SRSRLLYAE------------------------------- stg_DmelP139_AA --------SRSRLML--------------------------------- CDC25_AqueP217_AA --------HRHSVPDIH------------------------------- CDC25C_HsapP199_AA --------IALLVKDMSP------------------------------ CDC25_NvecP153_AA --------FRPGLNYR-------------------------------- CDC25_SpurP196_AA --------TRSKSLF--------------------------------- CDC25A_HsapP188_AA --------MYSRLKKL-------------------------------- CDC25B_HsapP189_AA --------LCSRLQDQ-------------------------------- R05H5.2_CeleP166_AA --------PRARLLFEPCFTEID------------------------- K06A5.7_CeleP116_AA QVITPDFPDRPSESSSTTPAGEHLPLGEGGHQIPCGILDFSSISDDAE