MUSCLE (3.8) multiple sequence alignment DDB_G0280831_DdisP084_AA_256-466 ------PYELVLVRHGQSEGNEAQARSKRGDLSAYTEEFKKKHSSV----YRLTDKGVLQ YLR345W_ScerP047_AA_284-505 MNLRQKKGCVYFARCGTSDKDNYIH---DEELNEEGIHYSQVLKDFVLQRIKQKRQAKKN PFK26_ScerP034_AA_392-634 ---NLADRQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKF----IARQREIFYQ DDB_G0276253_DdisP086_AA_310-506 MNLHLTPRPILLCRSGESEWEVLGRKGGDSELTAEGENFSHRLASW----VD---E---- DDB_G0282759_DdisP087_AA_381-583 MNLHLHPRPIWLTRQGESEFNAQNRIGGDSDLTERGDNYAHQLAVW----IS---E---- PFKFB-2_NvecP127_AA_274-471 MNLHVRKRSIYLVRHAECENNVHQLLGGDTDLTKRGDEFAQTLAAF----IN---E---- PFKFB_MbreP113_AA_292-508 MNIHIEKRHIYISRHGESMYNTKGLIGGDSDLSPRGRLYARRLRNF----MA---KFVSW FBP26_ScerP038_AA_217-416 MNIRPKPKYIWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQL----VK---E---- K02B2.1_CeleP114_AA_238-436 MNIHLLPRSIYLTRHGQSEYNAMGRLGGDSPLTEDGQKYASALADF----FE---E---- Y110A7A.6_CeleP205_AA_239-446 MNIHLLPRSIYLSRHGESEYNRIGRLGGDSPLSENGLNYAGKLREY----FE---K---- PFKFB-1_NvecP126_AA_220-442 MNIHITPKAIYLTRHGESEYNLKGRIGGDSDLSHRGRLYGEKLAEF----MA---E---- PFKFB_SpurP168_AA_271-484 MNIHIIPRTIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEY----MS---T---- PFKFB_AqueP189_AA_235-447 MNIHIRPRSIYLCRHGESICNMYGRIGGDSELSERGFEFARKLSEY----IS---T---- Pfrx_DmelP105_AA_458-661 MNIHITPRTIYLTRHGESEYNLSGLIGGDSNLSARGHQYANALSTF----IA---Q---- PFKFB3_HsapP148_AA_253-459 MNIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKF----VE---E---- PFKFB2_HsapP147_AA_242-455 MNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKF----LE---E---- PFKFB1_HsapP146_AA_244-469 MNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANF----IQ---S---- PFKFB4_HsapP149_AA_242-466 MNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAQF----IS---D---- : : * . : *. : DDB_G0280831_DdisP084_AA_256-466 AKIAGKWVRENISEVFD---RYYTSEYVRAMETASLL---GLPDADWLTEIQLRERDKGK YLR345W_ScerP047_AA_284-505 SDSLVEVIDGSHDEDLKTSLIVWTGPRKRTHDTALFFSKEGIKVQQRSE---LRQLNPGS PFK26_ScerP034_AA_392-634 NLMQQKKNNENTDGNIYNDFFVWTSMRARTIGTAQYFNEDDYPIKQMKM---LDELSAGD DDB_G0276253_DdisP086_AA_310-506 -------------NSQNEEVTVWTSTFKRSIRTAQYI---PHPKIHVKA---LDDLDRGE DDB_G0282759_DdisP087_AA_381-583 ------WCSKVRADGYDGEVVVWTSSLKRAIRTAQYI---SQPKVVMRA---LDEIDAGV PFKFB-2_NvecP127_AA_274-471 -------------QDIP-DLKVWTSQLKRAVQTAKYIQ--HAPVEPWKA---LNEIDYGI PFKFB_MbreP113_AA_292-508 RSDGDGDGDDTNGEKLD-NLRVWCSSLNRTIQTVEHF----RYKEAWKA---LDELDAGE FBP26_ScerP038_AA_217-416 -------------SAGEINLTVWTSTLKRTQQTANYL---PYKKLQWKA---LDELDAGV K02B2.1_CeleP114_AA_238-436 -------------EEVP-GLRVWCSQKVRAAQTAQHLKP-DFHTEYWKA---LDELDAGI Y110A7A.6_CeleP205_AA_239-446 -------------EDLD-DFRVWSSQKIRAAQTASHLKDLAGHTEFWKC---LDEIDAGI PFKFB-1_NvecP126_AA_220-442 -------------QKLQ-DFRVWTSEFKRTIQTTEHIK--GVSTEKWAA---LNEIDAGV PFKFB_SpurP168_AA_271-484 -------------QNLQ-DLKVWTSRLKRTVQTASSI---DVAIEQWKS---LDELDAGV PFKFB_AqueP189_AA_235-447 -------------QDLP-GLKIWTSQLKRTKQTAELL---DGPKEQWRA---LNELDVGD Pfrx_DmelP105_AA_458-661 -------------QQID-GLRVWTSWMKRAIQTVADV---KAPQERWKA---LNEIDAGH PFKFB3_HsapP148_AA_253-459 -------------QNLK-DLRVWTSQLKSTIQTAEAL---RLPYEQWKA---LNEIDAGV PFKFB2_HsapP147_AA_242-455 -------------QEIT-DLKVWTSQLKRTIQTAESL---GVPYEQWKI---LNEIDAGV PFKFB1_HsapP146_AA_244-469 -------------QGIS-SLKVWTSHMKRTIQTAEAL---GVPYEQWKA---LNEIDAGV PFKFB4_HsapP149_AA_242-466 -------------QNIK-DLKVWTSQMKRTIQTAEAL---GVPYEQWKV---LNEIDAGV : . : *. . * : . * DDB_G0280831_DdisP084_AA_256-466 MDNISWTDKKDHFGNEMMMRKRDSFFWCPP--GGESIANICQRVEHTFITLRRECSNKRV YLR345W_ScerP047_AA_284-505 IADLTDQQIMDKFPSEYKESLKDPYHFRFP--RAESYHDLAVRMEPLLLEMEHTSKD--I PFK26_ScerP034_AA_392-634 YDGMTYPEIKNNFPEEFEKRQKDKLRYRYPGIGGESYMDVINRLRPVITELERIEDN--V DDB_G0276253_DdisP086_AA_310-506 WQGLKREDILKKMPEEFGAHSDDKLGYRIP--RGECYLDVIQRLESVILELERTKNT--S DDB_G0282759_DdisP087_AA_381-583 CDGMTYEEIQEKMPDERAARDSDKLQYRYP--RGESYEDVIQRLEPLLLELERTKSP--V PFKFB-2_NvecP127_AA_274-471 YDGRPVSDLNTMGPDDIKARHKNMFIYRYP--LGESYSDVCARLEPVIMELER-QNN--V PFKFB_MbreP113_AA_292-508 CDGLSYEETKERFPEMYKERQGNKYWTRYP--RGESYADVVQRLEPRIMELERMRDN--V FBP26_ScerP038_AA_217-416 CDGMTYEEIEKEYPEDFKARDNDKYEYRYR--GGESYRDVVIRLEPVIMELER-QEN--V K02B2.1_CeleP114_AA_238-436 CEGLTYEDILQRYPKQADDRATDKYHYRYP--SGESYEDVVSRLEPVIMELER-QAN--V Y110A7A.6_CeleP205_AA_239-446 CEGLTYEDFEARYPKQFAERDKDKYHYRYP--SGESYEDLVARLEPVIMELER-QSN--V PFKFB-1_NvecP126_AA_220-442 CEGMTYEEIQENFPEDFAKRDEDKFHYRYR--RGESYEDLVARLEPVIMELER-QHN--V PFKFB_SpurP168_AA_271-484 CDGLTYEEIQKGHPEEFALRDQDKFHYRYP--MGESYQDLVARLEPVIMELER-QKN--V PFKFB_AqueP189_AA_235-447 CEALSYEQIQEKFPREFALRDQDKYRYRYP--RGESYEDLVHRLEPVIMELER-QDN--V Pfrx_DmelP105_AA_458-661 CEEMTYEQIKEKFPEEFKARDVNKFAYRYP--RGESYEDLVARLEPVIMELER-QGN--V PFKFB3_HsapP148_AA_253-459 CEELTYEEIRDTYPEEYALREQDKYYYRYP--TGESYQDLVQRLEPVIMELER-QEN--V PFKFB2_HsapP147_AA_242-455 CEEMTYAEIEKRYPEEFALRDQEKYLYRYP--GGESYQDLVQRLEPVIMELER-QGN--V PFKFB1_HsapP146_AA_244-469 CEEMTYEEIQEHYPEEFALRDQDKYRYRYP--KGESYEDLVQRLEPVIMELER-QEN--V PFKFB4_HsapP149_AA_242-466 CEEMTYEEIQDNYPLEFALRDQDKYRYRYP--KGESYEDLVQRLEPVIMELER-QEN--V : : .*. :: *: : : . DDB_G0280831_DdisP084_AA_256-466 IIVAHGEIMWAFRVRLERLSQLR--FHQLQSSDDPRDQIHNTTILHYSRI---------- YLR345W_ScerP047_AA_284-505 LIIAHESTL---RVLYGYLMACT--CVELPNLNFTRDKLVEISFSPFCNTVELLNI---- PFK26_ScerP034_AA_392-634 LIITHRVVA---RALLGYFMNLS--MGIIANLDVPLHCVYCLEPKPYGITWSLWEYDEAS DDB_G0276253_DdisP086_AA_310-506 LIVSHPAPL---RCLYGYITGEP--IEKFPYINIPLNTVISLLPTAYGCEVKTYK----- DDB_G0282759_DdisP087_AA_381-583 LIVSHQATL---RCLYSYLKGRV--KEECPFINIPLHTLIQLSPKAYGCEETTF------ PFKFB-2_NvecP127_AA_274-471 VLIVHEAVM---QIIMAYFTNHT--PDEIPNLDIPLHTVFKLTPIAYGCRVERFPLE--- PFKFB_MbreP113_AA_292-508 LVVCHQAVA---RCLLAYFQNMSDLADQLPYLKIPLHTVFKITPIPYGNRIEVFDLGV-- FBP26_ScerP038_AA_217-416 LIITHQAVL---RCIYAYFMNVP--QEESPWMSIPLHTLIKLEPRAYGTKVTKIKANIP- K02B2.1_CeleP114_AA_238-436 LVVSHQAVL---RCVLAYFYDRP--LSELPYIDIPLHSLVKLTPRAYHCDSTIYALD--- Y110A7A.6_CeleP205_AA_239-446 LVISHQAVL---RCILAYFTNKN--RDDLPYLKVPLHTVIKLTPKAYSCEIELFKFDIEA PFKFB-1_NvecP126_AA_220-442 LVVCHQAVG---RCLLAYFLDKN--YEELPYIKVPLHSVLKLTTEAYGCKIEQFDLHIPA PFKFB_SpurP168_AA_271-484 LVICHQGVM---RCLLAYFLDKN--SDELPYLKCPLHTVIKLTPVAYGCRVETVTLNIPA PFKFB_AqueP189_AA_235-447 LVICHQAVS---RCILAYFLDKS--NEELPYIRVPLHSIIKLTPVAYGCKVESHKIDVPC Pfrx_DmelP105_AA_458-661 LVVSHQAVL---RCLFAYFLDKS--ADELPYLYVPLHTVIKLTPVAYGCKVEHIKLPIDA PFKFB3_HsapP148_AA_253-459 LVICHQAVL---RCLLAYFLDKS--AEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVES PFKFB2_HsapP147_AA_242-455 LVISHQAVM---RCLLAYFLDKG--ADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEA PFKFB1_HsapP146_AA_244-469 LVICHQAVM---RCLLAYFLDKS--SDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEA PFKFB4_HsapP149_AA_242-466 LVICHQAVM---RCLLAYFLDKA--AEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAA ::: * . : . : : DDB_G0280831_DdisP084_AA_256-466 -------------------------- YLR345W_ScerP047_AA_284-505 -------------------------- PFK26_ScerP034_AA_392-634 DSFSKVPQTDLNTTRVKEV------- DDB_G0276253_DdisP086_AA_310-506 -------------------------- DDB_G0282759_DdisP087_AA_381-583 -------------------------- PFKFB-2_NvecP127_AA_274-471 -------------------------- PFKFB_MbreP113_AA_292-508 -------------------------- FBP26_ScerP038_AA_217-416 -------------------------- K02B2.1_CeleP114_AA_238-436 -------------------------- Y110A7A.6_CeleP205_AA_239-446 VNTYR--------------------- PFKFB-1_NvecP126_AA_220-442 VNTHRQKPEDVSVSRDSAHALQ---- PFKFB_SpurP168_AA_271-484 VDTHRPRPDECNTN------------ PFKFB_AqueP189_AA_235-447 VDTYRGKPENLEL------------- Pfrx_DmelP105_AA_458-661 VDTH---------------------- PFKFB3_HsapP148_AA_253-459 VCTHRER------------------- PFKFB2_HsapP147_AA_242-455 VNTHRDKPTNNFPK------------ PFKFB1_HsapP146_AA_244-469 VNTHREKPENVDITREPEEALDTVPA PFKFB4_HsapP149_AA_242-466 VNTHRDRPQNVDISRPPEEALVTVP-