MUSCLE (3.8) multiple sequence alignment VIP1_ScerP049_AA_498-1067 ----AYYDSCANILRSTFIEAKK-------KMDMEKKNLPIIREEKEQKWVFKGLAIIIR PPIP5K_MbreP119_AA_414-1002 -------------------------------LALQSPQQPL----RRDAPELRCVIAVIR PPIP5K_AqueP197_AA_371-887 -----------------------------------APTVPVPIFSRGR-CELRCVIGVIR F46F11.1_CeleP088_AA_356-921 --------------------------------------------PSGKLAELRCVVAVIR PPIP5K_NvecP134_AA_327-865 ---------------------------------ESSEDRPITDTLNGTMMELRCVIGIIR l(1)G0196_DmelP118_AA_352-943 -NSNKYYDDCAKILGNMILRELTPTLHIPWSVPFQLDDPPIVPTTFGKMMELRCVVAVIR PPIP5K_SpurP177_AA_346-937 -NSNKYYDDCAKILGNMIMRELAPKYNIPWQMFTLDEEIPYMPTTSGTMMELRCVIAVIR PPIP5K1_HsapP164_AA_339-924 KNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIR PPIP5K2_HsapP165_AA_328-942 KNSMKYYDDCAKILGNIVMRELAPQFHIPWSIPLEAEDIPIVPTTSGTMMELRCVIAVIR :. : :** VIP1_ScerP049_AA_498-1067 HADRTPKQKFKHSFTSPIFISLLKGH-------KEEVVIRNVNDLKIVLQALRIALDEK- PPIP5K_MbreP119_AA_414-1002 HSDRTPKEKLKMNVTHVELLEVFKRWSPEGMSATKEVKLKSRKHLQDVLRRVQNLLRWDQ PPIP5K_AqueP197_AA_371-887 HADRTPKQKMKMIVRHHYFFSLFEEL---GGYKKQQIKIKKPKELQKVLDIVRKLINEG- F46F11.1_CeleP088_AA_356-921 HGDRTPKQKMKLIVTDQRFFALFEKY---DGYKKHEIKMKKPNQLMEVLELARALVIEKQ PPIP5K_NvecP134_AA_327-865 HGDRTPKQKLKMEIRHPRFIQLFKRH---NSHNEKKLKLKRPKQLQEILDIVRDLLEEH- l(1)G0196_DmelP118_AA_352-943 HGDRTPKQKMKVEVRHPKFFEIFEKY---DGYKLGHVKLKRPKQLQEILDIARFLLSEI- PPIP5K_SpurP177_AA_346-937 HGDRTPKQKMKMEVKHPKFFSLFESY---GGRSKGKVKLKRPEQLQKILDVSRYLLGELK PPIP5K1_HsapP164_AA_339-924 HGDRTPKQKMKMEVKHPRFFALFEKH---GGYKTGKLKLKRPEQLQEVLDITRLLLAEL- PPIP5K2_HsapP165_AA_328-942 HGDRTPKQKMKMEVRHQKFFDLFEKC---DGYKSGKLKLKKPKQLQEVLDIARQLLMEL- *.*****:*:* . :: ::: : :. : * :* . : VIP1_ScerP049_AA_498-1067 -----------------------------AGNP---AKIKVLANALEKKLNFPGT--KIQ PPIP5K_MbreP119_AA_414-1002 RLS--------------------------DEEK---SNLKQIEHVLTRWP-ISGINRKVQ PPIP5K_AqueP197_AA_371-887 -----------------------------EDDEIFFNKLQQLKTVLEMYDHFSGINRKVQ F46F11.1_CeleP088_AA_356-921 RDRHQILEKLREGTGEEEIHKSEHDLEVCEEEM---KKWEQMRTVLEMYGHFSGINRKVQ PPIP5K_NvecP134_AA_327-865 ----HAGVTM-------------------FENP---NKLRQLKNVLEMYGHFSGINRKIQ l(1)G0196_DmelP118_AA_352-943 --HTKAHAEI-------------------EEKE---SKLEQLKNVLEMYGHFSGINRKVQ PPIP5K_SpurP177_AA_346-937 WQKHRSQPEI-------------------EERE---SKLEQLKAVLEMYGHFSGINRKVQ PPIP5K1_HsapP164_AA_339-924 --EKEPGGEI-------------------EEKT---GKLEQLKSVLEMYGHFSGINRKVQ PPIP5K2_HsapP165_AA_328-942 --GQNNDSEI-------------------EENK---PKLEQLKTVLEMYGHFSGINRKVQ : : .* :.* *:* VIP1_ScerP049_AA_498-1067 LK-------PVLNKENEV-----------EKVQFILKWGGEPTHSAKYQATELGEQMR-- PPIP5K_MbreP119_AA_414-1002 FKPTSYVHTRTGKPIINK-------------AQLIVKWGGEVTPMGLDQAQKAGVQFRET PPIP5K_AqueP197_AA_371-887 FK---LIHKDINNTPLES-----------PALLLIAKWGGEVTPAGERVAEELGKAFR-C F46F11.1_CeleP088_AA_356-921 MK---YLKERETKTSDEE----LRRE--GPALLLILKWGGELTTAGNMQAEALGRLFR-T PPIP5K_NvecP134_AA_327-865 LK---YL--GFVKDTPDSSEKAYKSSKDEEAILLIMKWGGELTATGKIQAEELGRAFR-C l(1)G0196_DmelP118_AA_352-943 MK---YQPKGRPRGSSSDDTNLAADQPVEPSLVLILKWGGELTPAGRIQAEELGRIFR-C PPIP5K_SpurP177_AA_346-937 LK---YLPKGIMKHSSSEED--SKGE---PSLLLILKWGGELTPAGRVQAEELGRAFR-C PPIP5K1_HsapP164_AA_339-924 LT---YYPHGV-KASNEGQD--PQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFR-C PPIP5K2_HsapP165_AA_328-942 LT---YLPHGCPKTSSEEED--SRRE--EPSLLLVLKWGGELTPAGRVQAEELGRAFR-C :. . . :: ***** * . * * :* VIP1_ScerP049_AA_498-1067 -------------------QDFDLLNKSILQNIKIFSSSERRVLHTAQYWTRALFGAD-E PPIP5K_MbreP119_AA_414-1002 MYPS-----------SDQDNGLLRLHSTYRHDLKLYSSDEGRVQMTAAAFAKGLLQLDGE PPIP5K_AqueP197_AA_371-887 MYPG---GEG--EYSLLPGSGFLRLHSTYRHDLKVYASDEGRVQLSAAAFTKGLLDLEGN F46F11.1_CeleP088_AA_356-921 LYPGIRRTDGKSSPEDTQGLGFLRLHSTYRHDLKIYASDEGRVQTTAAAFAKGLLALEGE PPIP5K_NvecP134_AA_327-865 MYPG---GQG--EYSNLPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGFLALEGE l(1)G0196_DmelP118_AA_352-943 MYPG---GQGRSDYSGTQGLGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGE PPIP5K_SpurP177_AA_346-937 IYPG---GQG--DYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFTKGMLALEGE PPIP5K1_HsapP164_AA_339-924 MYPG---GQG--DYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGE PPIP5K2_HsapP165_AA_328-942 MYPG---GQG--DYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGE .: *:.: :::*:::*.* ** :* ::..:: : : VIP1_ScerP049_AA_498-1067 LGSDEISIRK------DLLDDSNAA-KDLMDKVKKKLKPLLREGKE-------------- PPIP5K_MbreP119_AA_414-1002 ITPILVSLVRKDNAVNALLDDTKPA-RAQMDEVKKKVHGTLLADQSW-PEVAAKIAPLSA PPIP5K_AqueP197_AA_371-887 MASILAHLVKMDQNTTDMLDTSSDA-AESLNRVKQDLHQMLQSTRDFDAEAIKNLAP--T F46F11.1_CeleP088_AA_356-921 LTPILMQMVKSA-NTDGLLDDDCQA-RLYQTELKRYLHKALQADRDFTPQDYLELNP--N PPIP5K_NvecP134_AA_327-865 LTPILVHLVRSDKNTTEMLDTSDQA-TKLMTRVKQRLHEILSQDKKFTDEDISKLAP--T l(1)G0196_DmelP118_AA_352-943 LTPILVQMVKSA-NTNGLLDNDCDS-SKYQNLAKGRLHELMQNDREFSKEDRELINP--C PPIP5K_SpurP177_AA_346-937 LTPILVQMVKSA-NTSGLLDHEKES-VTIQGRVKERLCQSFSRDRTFGPRDFNELAP--T PPIP5K1_HsapP164_AA_339-924 LTPILVQMVKSA-NMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAP--T PPIP5K2_HsapP165_AA_328-942 LTPILVQMVKSA-NMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTP--S : . : . :** : * : : VIP1_ScerP049_AA_498-1067 -APPQFAWPSKMPEPYLVIKRVVELMNYHKKIMDNNFAKKDVNSMQTRWCTSEDPSLFKE PPIP5K_MbreP119_AA_414-1002 MSYSQRKALRKLDNPHKAMTRLYNLVVDFVTSLGDRIEQ----DPNVRAYQGEPLVLLRR PPIP5K_AqueP197_AA_371-887 LSPPLLAAIKEVKNPHKTCRTIQENLRTLVMSFEDIARK----KSDLQLYHGESIKLAIS F46F11.1_CeleP088_AA_356-921 GLRAITAAMEFIKNPRKMCHEIAGYVEKMCGVIVEYSQTR---PTGSTLYLQESMDLAQR PPIP5K_NvecP134_AA_327-865 KSASLIEAIKKVQNPREMCAKLANMVHDLTEQLKDMINQKKYDPRDPFLYHDDTLELMTH l(1)G0196_DmelP118_AA_352-943 NSKSITQALDFVKNPVDCCHHVHLLIRELLHIISIKKDDPK--TKDAILYHGETWDLMRC PPIP5K_SpurP177_AA_346-937 GSKSLQDSLTFIKNPVRMCEKVHRVIKNHTKMIKDTMENPE--NKDFGLYHHETLELMLR PPIP5K1_HsapP164_AA_339-924 RSTSLLNSMTIIQNPVKVCDQVFALIENLTHQIRERMQDPR--SVDLQLYHSETLELMLQ PPIP5K2_HsapP165_AA_328-942 GSISLIKSMHLIKNPVKTCDKVYSLIQSLTSQIRHRMEDPK--SSDIQLYHSETLELMLR . : :* : : : : * VIP1_ScerP049_AA_498-1067 RWDKLFKEFNNAEKV-----DPSKISELYDTMKYDALHN---RQFLENIFDPGLPNEAIA PPIP5K_MbreP119_AA_414-1002 RWEKLRDEFFDTAKQ---KFVVSKIPDIHDSIKYHLQHN---AHF-------GIDQS--- PPIP5K_AqueP197_AA_371-887 RWKKLEKDFVLSNGK----FDISKIPDIYDCIKYDLQHN---RIL-------ELSDG--- F46F11.1_CeleP088_AA_356-921 RWNKELREFRRKNKHGEVEFDISKIPDIYDNIKYDMEHN---PDL-------CINNE--- PPIP5K_NvecP134_AA_327-865 RWIKLDKDFRLKHGM----YDISLIPDIYDGIKYDLQHN---NQL-------GLKNT--- l(1)G0196_DmelP118_AA_352-943 RWEKIEKDFSTKSKL----FDISKIPDIYDCIKYDLQHN--QHTL-------QYDQA--- PPIP5K_SpurP177_AA_346-937 RWVKLEKDFKLKSGR----FDITKVPDIYDCIKYDMQHNFILKTL-------GFSHM--- PPIP5K1_HsapP164_AA_339-924 RWSKLERDFRQKSGR----YDISKIPDIYDCVKYDVQHN---GSL-------GLQGT--- PPIP5K2_HsapP165_AA_328-942 RWSKLEKDFKTKNGR----YDISKIPDIYDCIKYDVQHN---GSL-------KLENT--- ** * :* : :.:::* :** ** : VIP1_ScerP049_AA_498-1067 DELGSHSLVDRYPINVLAKNNFKIIDSHSMNNSGKNSSNSVGSLGWVLESGKTSTARNPK PPIP5K_MbreP119_AA_414-1002 ------------------------------------------------------------ PPIP5K_AqueP197_AA_371-887 ------------------------------------------------------------ F46F11.1_CeleP088_AA_356-921 ------------------------------------------------------------ PPIP5K_NvecP134_AA_327-865 ------------------------------------------------------------ l(1)G0196_DmelP118_AA_352-943 ------------------------------------------------------------ PPIP5K_SpurP177_AA_346-937 ------------------------------------------------------------ PPIP5K1_HsapP164_AA_339-924 ------------------------------------------------------------ PPIP5K2_HsapP165_AA_328-942 ------------------------------------------------------------ VIP1_ScerP049_AA_498-1067 SSSQFDEPRFMQLRELYKLAKVLFDFICPKEYGISDAEKLDIGLLTSLPLAKQILNDI-- PPIP5K_MbreP119_AA_414-1002 ----------SE---ILTLSQHLANVVVPQEYGVTNEEKLGIGYAIGEDLMRKIVHDLRV PPIP5K_AqueP197_AA_371-887 ----------VS---LYKAVSNLADIVIPLEYGITIEDKISISKIVCRHLLKKIRADLSH F46F11.1_CeleP088_AA_356-921 ----------VEFERMYVCVKNMADIVVPQEYGIKTENKMVIAQRVCTPLLRKIRNDLHR PPIP5K_NvecP134_AA_327-865 ----------TE---MYNVAKALADIVIPQEYGLSAEEKVKIARKMCIRLLRKIQGDLKH l(1)G0196_DmelP118_AA_352-943 ----------EE---LYIYAKNLADIVIPQEYGLTPQEKLAIGQGICSPLLRKIKGDLQR PPIP5K_SpurP177_AA_346-937 ----------DE---LYNSAEMLADFVIPQEYGITTSEKLEIGKGICTPLLKKIRSDLHR PPIP5K1_HsapP164_AA_339-924 ----------AE---LLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQR PPIP5K2_HsapP165_AA_328-942 ----------ME---LYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQR . : . : :.: * ***:. :*: *. * .:* *: VIP1_ScerP049_AA_498-1067 --------GDMKNRETPACVA------------------YFTKESHIYTLLNIIYES--G PPIP5K_MbreP119_AA_414-1002 SAGQDAQHDVFQHEVSHRLNSGDSFIKVRSPNRHVRTRLYFTSESHIHALVNVLRCGDYG PPIP5K_AqueP197_AA_371-887 TYNIG---SDFIHRLDPKKSKG-----VISPDRCVRTRLYFTSESHIHSLVNILKYG--G F46F11.1_CeleP088_AA_356-921 CLENKES-EETQTRLDPRASQG-----IATPFRHVRTRLYFTSESHIHTLMNLIRYG--N PPIP5K_NvecP134_AA_327-865 ADT-----EDTHTRLNPEYSQS-----VITPHRHVRTRLYFTSESHVHSIINALRYG--K l(1)G0196_DmelP118_AA_352-943 NIDEVE--DEFMNRLNPHYSHG-----VASPQRHVRTRLYFTSESHVHSLLTVLRYG--G PPIP5K_SpurP177_AA_346-937 INSN----DETTYRLNPLYSKG-----VMSPDRQVRTRLYFTSESHIHTLLSCLRYG--G PPIP5K1_HsapP164_AA_339-924 THE-----DESVNKLHPLYSRG-----VLSPGRHVRTRLYFTSESHVHSLLSVFRYG--G PPIP5K2_HsapP165_AA_328-942 TQD-----DDTVNKLHPVYSRG-----VLSPERHVRTRLYFTSESHVHSLLSILRYG--A ***.***:::::. : . VIP1_ScerP049_AA_498-1067 I-----------------PMRIAR------------------------------------ PPIP5K_MbreP119_AA_414-1002 LFSAGPTRKYSYSDLVEGQSKDDQAGATANGDGDADRDEDYRSRAASDLASRWQPRLQAN PPIP5K_AqueP197_AA_371-887 I-----------------PIPEEN------------------------------------ F46F11.1_CeleP088_AA_356-921 LC----------------SVDDKK------------------------------------ PPIP5K_NvecP134_AA_327-865 MFES--------------ENQDAQ------------------------------------ l(1)G0196_DmelP118_AA_352-943 LLN---------------VVTDEQ------------------------------------ PPIP5K_SpurP177_AA_346-937 LC----------------DESDPN------------------------------------ PPIP5K1_HsapP164_AA_339-924 LLD---------------ETQDAQ------------------------------------ PPIP5K2_HsapP165_AA_328-942 LCNTNDSQNEDGGMVKEMESKDEQ------------------------------------ : . VIP1_ScerP049_AA_498-1067 -------------------NALPELDYLSQITFELYESTDASGQK-----SHSIRLKMSP PPIP5K_MbreP119_AA_414-1002 TDVPLVSSPEAWLSAKAYICKLEELGYLTHIVCRLFERHDMDGSDPA---RFFVE----- PPIP5K_AqueP197_AA_371-887 -----------YGK----LHDPPELNYLSQVVFMVFENKTEPIDSY----RYRVEVHFSP F46F11.1_CeleP088_AA_356-921 -----------WQRAMNFLSGVTEFNYMTQVVLMVYEDSRKENDEADTGPRFHIEILFSP PPIP5K_NvecP134_AA_327-865 -----------WKRAIDFLSEIPELHYMTQIVLMLYEDPTADLQSDN---RFHIELHFSS l(1)G0196_DmelP118_AA_352-943 -----------WRRAMDYISMVSELNYMSQIVIMLYEDPTKDPTSEE---RFHVELHFSP PPIP5K_SpurP177_AA_346-937 -----------WQNSCDYLGGIRELNYMTQIVLMLYEDPSKDPMSDD---RFRVELHFSP PPIP5K1_HsapP164_AA_339-924 -----------WQRALDYLSAISELNYMTQIVIMLYEDNTQDPLSEE---RFHVELHFSP PPIP5K2_HsapP165_AA_328-942 -----------WKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEE---RFHVELHFSP *: *::::. ::* . . : VIP1_ScerP049_AA_498-1067 GCHTQDPLDVQLDDRHYIS------------- PPIP5K_MbreP119_AA_414-1002 -------------------------------- PPIP5K_AqueP197_AA_371-887 GVKS---------------------------- F46F11.1_CeleP088_AA_356-921 GLYPCF-------------------------- PPIP5K_NvecP134_AA_327-865 G------------------------------- l(1)G0196_DmelP118_AA_352-943 GVNCCVQ-KNLPPGPGF--------------- PPIP5K_SpurP177_AA_346-937 GAKDCEDDENHPGCCPFRSVH----------- PPIP5K1_HsapP164_AA_339-924 GVKGVEEEGSAPAGCGF--------------- PPIP5K2_HsapP165_AA_328-942 GAKGCEEDKNLPSGYGYRPASRENEGRRPFKI