MUSCLE (3.8) multiple sequence alignment VIP1_ScerP049_AA MSGIKKEPIESDEVPQQETKNNLPSAPSEMSPLFLNKNTQKAMQSIAPILEGFSPKTSAS PPIP5K_MbreP119_AA -----MAGSVTSPPSGTPSPAPGGSRLEPPTPDD-------------------------- F46F11.1_CeleP088_AA ------------------------------------------------------------ PPIP5K_AqueP197_AA -----MAESLSDSLSR------RGLPSLKESDVS-------------------------- l(1)G0196_DmelP118_AA MSYTELESGYQDISQQHQQQNPHQSQPQQRVGFY-------------------------- PPIP5K_SpurP177_AA -------MDIPESLTSL-----NAAGGDERVNFI-------------------------- PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA MWSLTASEGESTTAHFF-----LGAGDEGLGTRG-------------------------- PPIP5K2_HsapP165_AA ---------MSEAPRFF-----VGPEDTEINPGN-------------------------- VIP1_ScerP049_AA ENMSLKLPPPGIQDDHSEENLTVHDTLQRTISTALGNGNNTNTVTTSGLKKADSESKSEA PPIP5K_MbreP119_AA ---------PRSPVSGSNDNKA-------------------------------MRPRSQS F46F11.1_CeleP088_AA -----------------MAHKG-------------------------------TESKEQI PPIP5K_AqueP197_AA ---------PSPSPLSSTKLFL-------------------------------DVELEQL l(1)G0196_DmelP118_AA ---------LGLQDGNGDTDFG-------------------------------DSNDGMD PPIP5K_SpurP177_AA ---------IGEIPSDAKSQAS-------------------------------ANNGLST PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA ---------IGMRPEESDSELL-------------------------------EDEEDEV PPIP5K2_HsapP165_AA ---------YRHFFHHADED---------------------------------DEEEDDS VIP1_ScerP049_AA DPEGLSNSNIVNDADNINSISKTGSPHLPQGTMDAEQTNMGTNSVPTSSASSRKSSTSHP PPIP5K_MbreP119_AA DPAEHDKKPVLATPPSGQNS---------------------------------------- F46F11.1_CeleP088_AA WP---------------YKI---------------------------------------- PPIP5K_AqueP197_AA AD--------------FNGV---------------------------------------- l(1)G0196_DmelP118_AA SDTSTSSSN-------SKQV---------------------------------------- PPIP5K_SpurP177_AA SPSAVSGLSRWEAMEIKPKV---------------------------------------- PPIP5K_NvecP134_AA -------------------I---------------------------------------- PPIP5K1_HsapP164_AA PP--------------EPQI---------------------------------------- PPIP5K2_HsapP165_AA PP--------------ERQI---------------------------------------- VIP1_ScerP049_AA KPRLPKVGKIGVCAMDAKVLS--------KPMRHILNRLIEH--GEFETVIFG-DKVILD PPIP5K_MbreP119_AA --------KDGNKLLSRRYTSSTDEFRSPRRLHDESDLADERPLHHVTLMVIAMEKKVMA F46F11.1_CeleP088_AA --------TIGICAMNRKATS--------KPMRAIMKKIIDFYGQWVDSFIFP-EQVIIN PPIP5K_AqueP197_AA --------TLGVCAMNKKSFS--------GPMNSILTRIGSH--EHVRVIIFT-DNTILY l(1)G0196_DmelP118_AA --------VVGICAMAKKTQS--------KPMKEILTRLGEF--EFIKLVTFE-ENVILR PPIP5K_SpurP177_AA --------VVGICCMGKKASS--------RPMREILHRLEKF--EYISLDIFD-EDMILN PPIP5K_NvecP134_AA --------KIGICAMNKKTKS--------TPMQEILSRIMRF--EFVDVVVFS-DDMILN PPIP5K1_HsapP164_AA --------IVGICAMTKKSKS--------KPMTQILERLCRF--DYLTVVILG-EDVILN PPIP5K2_HsapP165_AA --------VVGICSMAKKSKS--------KPMKEILERISLF--KYITVVVFE-EEVILN * : . * : . : :. :: VIP1_ScerP049_AA ERIENW-------PTCDFLISFFSSGFPLDKAIKYVKLRKP-FIINDLIMQKILWDRRLC PPIP5K_MbreP119_AA KPMQRLILLSLSASLGGRFVSTCCHRYPLSKVQDYVKLRSP-FLLNDLATQHLLLDRQSV F46F11.1_CeleP088_AA EPVENW-------PLCHCLVSFHSTEFPLEKAIAYVKLRNP-YVINNLDRQYDLLDRRTV PPIP5K_AqueP197_AA KPVEEW-------PYCDALIAFYSKGFPLDKALRYVKLKSPKMLVNDLEMQYALMDRRKV l(1)G0196_DmelP118_AA EPVQNW-------PTCDCLVSFHSKGFPLEKAIEYAQLRNP-FVLNNLHMQYDIQDRRRV PPIP5K_SpurP177_AA DPVESW-------PLCNALISFFSTGFPLHKAIEYAKLRKP-LVINDLEAQYNLHDRRKV PPIP5K_NvecP134_AA HQVEEW-------PLCDALISFYSSGFPLDKAIEYSKLRNP-FVLNDLEMQYTLLDRCAV PPIP5K1_HsapP164_AA EPVENW-------PSCHCLISFHSKGFPLDKAVAYSKLRNP-FLINDLAMQYYIQDRREV PPIP5K2_HsapP165_AA EPVENW-------PLCDCLISFHSKGFPLDKAVAYAKLRNP-FVINDLNMQYLIQDRREV :: . ::: . :** *. * :*..* ::*:* * : ** VIP1_ScerP049_AA LQVLEAYNVPTPPRLEISRDGGPRANEELRAKLREHGVEVKPVEEPEWKMVD-DDTLEVD PPIP5K_MbreP119_AA YEILEENGIPSPPHMVLRRSA-------------------------GDVVVEREDAIEIN F46F11.1_CeleP088_AA FKILSDNGIEHPRHGYVIRGR--------------------PNEP-DTELVEHPDHIEVN PPIP5K_AqueP197_AA YDILVKNGIEVPPHVICNRDG--------------------SDKGLKISEVD-EDTLEVN l(1)G0196_DmelP118_AA YAILEKEGIEIPRYAVLDRDS--------------------P-DPKHHELIESEDHVEVN PPIP5K_SpurP177_AA FEILSEEDILVPRHGIHDRDC----------------------DPDDFSLIENDDELEID PPIP5K_NvecP134_AA YELLKEGNIETPRYAILMRDE--------------------DGNPIDTNFVELEDSIQIG PPIP5K1_HsapP164_AA YRILQEEGIDLPRYAVLNRD---------------------PARPEECNLIEGEDQVEVN PPIP5K2_HsapP165_AA YSILQAEGILLPRYAILNRD---------------------PNNPKECNLIEGEDHVEVN :* .: * *. :: * :::. VIP1_ScerP049_AA GKTMTKPFVEKPVDGEDHNIYIYYHSKNGGGGRRLFRKVGNKSSEFDPTLVHPRTEGSYI PPIP5K_MbreP119_AA GKVMPKPFVMKPLDAENHNIYVYFSQHDGGGAQHLFRKKKDKASAFLPDCNTIPEEGDFI F46F11.1_CeleP088_AA GEVFNKPFVEKPISSEDHNVYIYYPSSVGGGSQRLFRKINNRSSWYSPKSE-VRKEGSYI PPIP5K_AqueP197_AA GVTFHKPFVEKPISAEDHNIYIYFPSDYGGGCQRLFRKVKDRSSTYSNESN-VRKDGSYI l(1)G0196_DmelP118_AA GITFNKPFVEKPVSAEDHNIYIYYPTSAGGGSQRLFRKIGSRSSVYSPESR-VRKTGSFI PPIP5K_SpurP177_AA DVIFRKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKMRNRSSIYSPESR-IRRAGSYM PPIP5K_NvecP134_AA NVVFQKPFVEKPVDAEDHNVFIYYPSSAGGGSQRLFRKVGSRSSVYSAESC-VRKFGSYI PPIP5K1_HsapP164_AA GAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESS-VRKTGSYI PPIP5K2_HsapP165_AA GEVFQKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESN-VRKTGSYI . : **** **:..*:**:::*: *** ..**** ..:* : *.:: VIP1_ScerP049_AA YEQFMDTDNFEDVKA--YTIGENFCHAETRKSPVVDG-IVRRNTHGKEVRYITELS-DEE PPIP5K_MbreP119_AA FEQFLPTGG-TDIKV--YTVGPNYAHAEGRKAPVVDG-KVLRDANGKEVRCPILLT-TFE F46F11.1_CeleP088_AA YEEFIPADG-TDVKV--YAVGPFYAHAEARKAPGLDG-KVERDSDGKEVRYPVILS-NKE PPIP5K_AqueP197_AA YEDFMATDG-TDVKV--YTVGPDYAHSEARKSPALDG-RVDRDDRGKEKRFPVLLT-TKE l(1)G0196_DmelP118_AA YEDFMPTDG-TDVKV--YTVGPDYAHAEARKSPALDG-KVERDSEGKEIRYPVILN-HSE PPIP5K_SpurP177_AA YEEFMPTDG-TDVKV--YTVGPDYAHAEARKSPALDG-KVERDSHGKEVRYPVILT-NSE PPIP5K_NvecP134_AA YEDFVPTDG-TDVKVCYHDIHSWLVHTVAVISPALGGSKLRASAQARNSRSPVKHNSHNE PPIP5K1_HsapP164_AA YEEFMPTDG-TDVKV--YTVGPDYAHAEARKSPALDG-KVERDSEGKEIRYPVMLT-AME PPIP5K2_HsapP165_AA YEEFMPTDG-TDVKV--YTVGPDYAHAEARKSPALDG-KVERDSEGKEVRYPVILN-ARE :*:*: :.. *:*. : : *: :* :.* : . ..: * . * VIP1_ScerP049_AA KTIAGKVSKAFSQMICGFDLLR------VSGKSYVIDVNGFSFVKDNKAYYDSCANILRS PPIP5K_MbreP119_AA KDIARRVTQAFKQNVCGFDLLRT-----SDNKSFVCDVNGWSFVKRSPHYYVDCARILRE F46F11.1_CeleP088_AA KQIAKKIVLAFGQTVCGFDLLR------ANGKSYVCDVNGFSFVKTSTKYYEDTAKILGN PPIP5K_AqueP197_AA KVIARKVCIAFKQTVCGFDLLR------SNGNSYVCDVNGFSFVKNSDKYYDDCSQIILE l(1)G0196_DmelP118_AA KLISRKVCLAFKQTVCGFDLLR------ANGKSYVCDVNGFSFVKNSNKYYDDCAKILGN PPIP5K_SpurP177_AA KMIARKVCLAFKQTVCGFDLLR------ASGRSYVCDVNGFSFVKNSNKYYDDCAKILGN PPIP5K_NvecP134_AA KKLKLKRPKQLQEIL---DIVRDLLEEHQAGVTMFENPNKLRQLKNVLEMYVEYCNVLVS PPIP5K1_HsapP164_AA KLVARKVCVAFKQTVCGFDLLR------ANGHSFVCDVNGFSFVKNSMKYYDDCAKILGN PPIP5K2_HsapP165_AA KLIAWKVCLAFKQTVCGFDLLR------ANGQSYVCDVNGFSFVKNSMKYYDDCAKILGN * : . : : : *::* . : . : * :* * . ..:: . VIP1_ScerP049_AA TFIEAKK----KMDME-------------KKNLPIIRE--EKEQKWVFKGLAIIIRHADR PPIP5K_MbreP119_AA MILSAIS--PLLLNKSYPVPSVDYTSDSTDLLALQSPQQPLRRDAPELRCVIAVIRHSDR F46F11.1_CeleP088_AA QIVRHYAKSK-NWRVPSDMPQPPILDLGLGDDPPMITT--PSGKLAELRCVVAVIRHGDR PPIP5K_AqueP197_AA SILSKVA--P-HY-IPENEPSI-------AHLAPTVPVPIFSRGRCELRCVIGVIRHADR l(1)G0196_DmelP118_AA MILRELT--P-TLHIPWSVPFQ-------LDDPPIVPT--TFGKMMELRCVVAVIRHGDR PPIP5K_SpurP177_AA MIMRELA--P-KYNIPWQMFTL-------DEEIPYMPT--TSGTMMELRCVIAVIRHGDR PPIP5K_NvecP134_AA RILQELA--P-QLYKPYNLLEES------SEDRPITDT--LNGTMMELRCVIGIIRHGDR PPIP5K1_HsapP164_AA TIMRELA--P-QFQIPWSIPTE-------AEDIPIVPT--TSGTMMELRCVIAIIRHGDR PPIP5K2_HsapP165_AA IVMRELA--P-QFHIPWSIPLE-------AEDIPIVPT--TSGTMMELRCVIAVIRHGDR .: :. : :***.** VIP1_ScerP049_AA TPKQKFKHSFTSPIFISLLKGH-------KEEVVIRNVNDLKIVLQALRIALDEK----- PPIP5K_MbreP119_AA TPKEKLKMNVTHVELLEVFKRWSPEGMSATKEVKLKSRKHLQDVLRRVQNLL-------- F46F11.1_CeleP088_AA TPKQKMKLIVTDQRFFALFEKY---DGYKKHEIKMKKPNQLMEVLELARALVIEKQRDRH PPIP5K_AqueP197_AA TPKQKMKMIVRHHYFFSLFEEL---GGYKKQQIKIKKPKELQKVLDIVRKLINE------ l(1)G0196_DmelP118_AA TPKQKMKVEVRHPKFFEIFEKY---DGYKLGHVKLKRPKQLQEILDIARFLLSEI---HT PPIP5K_SpurP177_AA TPKQKMKMEVKHPKFFSLFESY---GGRSKGKVKLKRPEQLQKILDVSRYLLGELKWQKH PPIP5K_NvecP134_AA TPKQKLKMEIRHPRFIQLFKRH---NSHNEKKLKLKRPKQLQEILDIVRDLLEE-----H PPIP5K1_HsapP164_AA TPKQKMKMEVKHPRFFALFEKH---GGYKTGKLKLKRPEQLQEVLDITRLLLAEL---EK PPIP5K2_HsapP165_AA TPKQKMKMEVRHQKFFDLFEKC---DGYKSGKLKLKKPKQLQEVLDIARQLLMEL---GQ ***:*:* . :: ::: : :. : * :* . : VIP1_ScerP049_AA -------------------------AGNPAKIKVLANALEKKLNFPGT--KIQLKP--VL PPIP5K_MbreP119_AA RWDQRLS------------------DEEKSNLKQIEHVLTRWP-ISGINRKVQFKPTSYV F46F11.1_CeleP088_AA QILEKLREGTGEEEIHKSEHDLEVCEEEMKKWEQMRTVLEMYGHFSGINRKVQMKY--LK PPIP5K_AqueP197_AA --GEDD-------------------EIFFNKLQQLKTVLEMYDHFSGINRKVQFKL--IH l(1)G0196_DmelP118_AA KAHAEI-------------------EEKESKLEQLKNVLEMYGHFSGINRKVQMKY--QP PPIP5K_SpurP177_AA RSQPEI-------------------EERESKLEQLKAVLEMYGHFSGINRKVQLKY--LP PPIP5K_NvecP134_AA HAGVTM-------------------FENPNKLRQLKNVLEMYGHFSGINRKIQLKYLGFV PPIP5K1_HsapP164_AA EPGGEI-------------------EEKTGKLEQLKSVLEMYGHFSGINRKVQLTY--YP PPIP5K2_HsapP165_AA NNDSEI-------------------EENKPKLEQLKTVLEMYGHFSGINRKVQLTY--LP : : .* :.* *:*:. VIP1_ScerP049_AA NKENE---------------VEKVQFILKWGGEPTHSAKYQATELGEQMR---------- PPIP5K_MbreP119_AA HTRTGKPI------------INKAQLIVKWGGEVTPMGLDQAQKAGVQFRETMYPS---S F46F11.1_CeleP088_AA ERETKTSDEE----LRRE--GPALLLILKWGGELTTAGNMQAEALGRLFR-TLYPGIRRT PPIP5K_AqueP197_AA KDINNTPLE-----------SPALLLIAKWGGEVTPAGERVAEELGKAFR-CMYPG---G l(1)G0196_DmelP118_AA KGRPRGSSSDDTNLAADQPVEPSLVLILKWGGELTPAGRIQAEELGRIFR-CMYPG---G PPIP5K_SpurP177_AA KGIMKHSSSEED--SKGE---PSLLLILKWGGELTPAGRVQAEELGRAFR-CIYPG---G PPIP5K_NvecP134_AA KDTPDSSEKAYK--SSKD--EEAILLIMKWGGELTATGKIQAEELGRAFR-CMYPG---G PPIP5K1_HsapP164_AA HGVKASNEGQD---PQRETLAPSLLLVLKWGGELTPAGRVQAEELGRAFR-CMYPG---G PPIP5K2_HsapP165_AA HGCPKTSSEEED--SRRE--EPSLLLVLKWGGELTPAGRVQAEELGRAFR-CMYPG---G :: ***** * . * * :* VIP1_ScerP049_AA -----------QDFDLLNKSILQNIKIFSSSERRVLHTAQYWTRALFGAD-ELGSDEISI PPIP5K_MbreP119_AA DQ--------DNGLLRLHSTYRHDLKLYSSDEGRVQMTAAAFAKGLLQLDGEITPILVSL F46F11.1_CeleP088_AA DGKSSPEDTQGLGFLRLHSTYRHDLKIYASDEGRVQTTAAAFAKGLLALEGELTPILMQM PPIP5K_AqueP197_AA EG--EYSLLPGSGFLRLHSTYRHDLKVYASDEGRVQLSAAAFTKGLLDLEGNMASILAHL l(1)G0196_DmelP118_AA QGRSDYSGTQGLGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQM PPIP5K_SpurP177_AA QG--DYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFTKGMLALEGELTPILVQM PPIP5K_NvecP134_AA QG--EYSNLPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGFLALEGELTPILVHL PPIP5K1_HsapP164_AA QG--DYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQM PPIP5K2_HsapP165_AA QG--DYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQM .: *:.: :::*:::*.* ** :* ::..:: : :: . : VIP1_ScerP049_AA RK------DLLDDSNAA-KDLMDKVKKKLKPLLREGKEAPPQFA---------------W PPIP5K_MbreP119_AA VRKDNAVNALLDDTKPA-RAQMDEVKKKVHGTLLADQSW-PEVAAKIAPLSAMSYSQRKA F46F11.1_CeleP088_AA VKSA-NTDGLLDDDCQA-RLYQTELKRYLHKALQADRDFTPQDYLELNPNGLRAITA--A PPIP5K_AqueP197_AA VKMDQNTTDMLDTSSDA-AESLNRVKQDLHQMLQSTRDFDAEAIKNLAPTLSPPLLA--A l(1)G0196_DmelP118_AA VKSA-NTNGLLDNDCDS-SKYQNLAKGRLHELMQNDREFSKEDRELINPCNSKSITQ--A PPIP5K_SpurP177_AA VKSA-NTSGLLDHEKES-VTIQGRVKERLCQSFSRDRTFGPRDFNELAPTGSKSLQD--S PPIP5K_NvecP134_AA VRSDKNTTEMLDTSDQA-TKLMTRVKQRLHEILSQDKKFTDEDISKLAPTKSASLIE--A PPIP5K1_HsapP164_AA VKSA-NMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTRSTSLLN--S PPIP5K2_HsapP165_AA VKSA-NMNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISLIK--S . :** : * : : VIP1_ScerP049_AA PSKMPEPYLVIKRVVELMNYHKKIMDNNFAKKDVNSMQTRWCTSEDPSLFKERWDKLFKE PPIP5K_MbreP119_AA LRKLDNPHKAMTRLYNLVVDFVTSLGDRIE----QDPNVRAYQGEPLVLLRRRWEKLRDE F46F11.1_CeleP088_AA MEFIKNPRKMCHEIAGYVEKMCGVIVEYSQ---TRPTGSTLYLQESMDLAQRRWNKELRE PPIP5K_AqueP197_AA IKEVKNPHKTCRTIQENLRTLVMSFEDIAR----KKSDLQLYHGESIKLAISRWKKLEKD l(1)G0196_DmelP118_AA LDFVKNPVDCCHHVHLLIRELLHIISIKKD--DPKTKDAILYHGETWDLMRCRWEKIEKD PPIP5K_SpurP177_AA LTFIKNPVRMCEKVHRVIKNHTKMIKDTME--NPENKDFGLYHHETLELMLRRWVKLEKD PPIP5K_NvecP134_AA IKKVQNPREMCAKLANMVHDLTEQLKDMINQKKYDPRDPFLYHDDTLELMTHRWIKLDKD PPIP5K1_HsapP164_AA MTIIQNPVKVCDQVFALIENLTHQIRERMQ--DPRSVDLQLYHSETLELMLQRWSKLERD PPIP5K2_HsapP165_AA MHLIKNPVKTCDKVYSLIQSLTSQIRHRME--DPKSSDIQLYHSETLELMLRRWSKLEKD : :* : : : : * ** * : VIP1_ScerP049_AA FNNAEKV-----DPSKISELYDTMKYDALHN---RQFLENIFDPGLPNEAIADELGSHSL PPIP5K_MbreP119_AA FFDTAKQ---KFVVSKIPDIHDSIKYHLQHN---AHF-------GIDQS----------- F46F11.1_CeleP088_AA FRRKNKHGEVEFDISKIPDIYDNIKYDMEHN---PDL-------CINNE----------- PPIP5K_AqueP197_AA FVLSNGK----FDISKIPDIYDCIKYDLQHN---RIL-------ELSDG----------- l(1)G0196_DmelP118_AA FSTKSKL----FDISKIPDIYDCIKYDLQHN--QHTL-------QYDQA----------- PPIP5K_SpurP177_AA FKLKSGR----FDITKVPDIYDCIKYDMQHNFILKTL-------GFSHM----------- PPIP5K_NvecP134_AA FRLKHGM----YDISLIPDIYDGIKYDLQHN---NQL-------GLKNT----------- PPIP5K1_HsapP164_AA FRQKSGR----YDISKIPDIYDCVKYDVQHN---GSL-------GLQGT----------- PPIP5K2_HsapP165_AA FKTKNGR----YDISKIPDIYDCIKYDVQHN---GSL-------KLENT----------- * : :.:::* :** ** : VIP1_ScerP049_AA VDRYPINVLAKNNFKIIDSHSMNNSGKNSSNSVGSLGWVLESGKTSTARNPKSSSQFDEP PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA ------------------------------------------------------------ PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA ------------------------------------------------------------ PPIP5K_SpurP177_AA ------------------------------------------------------------ PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA ------------------------------------------------------------ PPIP5K2_HsapP165_AA ------------------------------------------------------------ VIP1_ScerP049_AA RFMQLRELYKLAKVLFDFICPKEYGISDAEKLDIGLLTSLPLAKQILNDI---------- PPIP5K_MbreP119_AA --SE---ILTLSQHLANVVVPQEYGVTNEEKLGIGYAIGEDLMRKIVHDLRVSAGQDAQH F46F11.1_CeleP088_AA --VEFERMYVCVKNMADIVVPQEYGIKTENKMVIAQRVCTPLLRKIRNDLH-RCLENKES PPIP5K_AqueP197_AA --VS---LYKAVSNLADIVIPLEYGITIEDKISISKIVCRHLLKKIRADLS-HTYNIG-- l(1)G0196_DmelP118_AA --EE---LYIYAKNLADIVIPQEYGLTPQEKLAIGQGICSPLLRKIKGDLQ-RNIDEVE- PPIP5K_SpurP177_AA --DE---LYNSAEMLADFVIPQEYGITTSEKLEIGKGICTPLLKKIRSDLH-RINSN--- PPIP5K_NvecP134_AA --TE---MYNVAKALADIVIPQEYGLSAEEKVKIARKMCIRLLRKIQGDLK-HADT---- PPIP5K1_HsapP164_AA --AE---LLRLSKALADVVIPQEYGISREEKLEIAVGFCLPLLRKILLDLQ-RTHE---- PPIP5K2_HsapP165_AA --ME---LYRLSKALADIVIPQEYGITKAEKLEIAKGYCTPLVRKIRSDLQ-RTQD---- . : . : :.: * ***:. :*: *. * .:* *: VIP1_ScerP049_AA GDMKNRETPAC--------VA----------YFTKESHIYTLLNIIYES--GI------- PPIP5K_MbreP119_AA DVFQHEVSHRLNSGDSFIKVRSPNRHVRTRLYFTSESHIHALVNVLRCGDYGLFSAGPTR F46F11.1_CeleP088_AA EETQTRLDPRASQG-----IATPFRHVRTRLYFTSESHIHTLMNLIRYG--NLC------ PPIP5K_AqueP197_AA SDFIHRLDPKKSKG-----VISPDRCVRTRLYFTSESHIHSLVNILKYG--GI------- l(1)G0196_DmelP118_AA DEFMNRLNPHYSHG-----VASPQRHVRTRLYFTSESHVHSLLTVLRYG--GLLN----- PPIP5K_SpurP177_AA DETTYRLNPLYSKG-----VMSPDRQVRTRLYFTSESHIHTLLSCLRYG--GLC------ PPIP5K_NvecP134_AA EDTHTRLNPEYSQS-----VITPHRHVRTRLYFTSESHVHSIINALRYG--KMFES---- PPIP5K1_HsapP164_AA DESVNKLHPLYSRG-----VLSPGRHVRTRLYFTSESHVHSLLSVFRYG--GLLD----- PPIP5K2_HsapP165_AA DDTVNKLHPVYSRG-----VLSPERHVRTRLYFTSESHVHSLLSILRYG--ALCNTNDSQ : ***.***:::::. : . : VIP1_ScerP049_AA ----------PMRIAR-------------------------------------------- PPIP5K_MbreP119_AA KYSYSDLVEGQSKDDQAGATANGDGDADRDEDYRSRAASDLASRWQPRLQANTDVPLVSS F46F11.1_CeleP088_AA ----------SVDDKK-------------------------------------------- PPIP5K_AqueP197_AA ----------PIPEEN-------------------------------------------- l(1)G0196_DmelP118_AA ----------VVTDEQ-------------------------------------------- PPIP5K_SpurP177_AA ----------DESDPN-------------------------------------------- PPIP5K_NvecP134_AA ----------ENQDAQ-------------------------------------------- PPIP5K1_HsapP164_AA ----------ETQDAQ-------------------------------------------- PPIP5K2_HsapP165_AA NEDGGMVKEMESKDEQ-------------------------------------------- . VIP1_ScerP049_AA -----------NALPELDYLSQITFELYESTDASGQKSH-----SIRLKMSPGCHTQ--- PPIP5K_MbreP119_AA PEAWLSAKAYICKLEELGYLTHIVCRLFERHDMDGSDPA---RFFVEWALSPGLRSV--- F46F11.1_CeleP088_AA ---WQRAMNFLSGVTEFNYMTQVVLMVYEDSRKENDEADTGPRFHIEILFSPGLYPCFLT PPIP5K_AqueP197_AA ---YGK----LHDPPELNYLSQVVFMVFENKT-EPIDSY---RYRVEVHFSPGVKS---- l(1)G0196_DmelP118_AA ---WRRAMDYISMVSELNYMSQIVIMLYEDPTKDPTSEE---RFHVELHFSPGVNCC--- PPIP5K_SpurP177_AA ---WQNSCDYLGGIRELNYMTQIVLMLYEDPSKDPMSDD---RFRVELHFSPGAKDC--- PPIP5K_NvecP134_AA ---WKRAIDFLSEIPELHYMTQIVLMLYEDPTADLQSDN---RFHIELHFSSG------- PPIP5K1_HsapP164_AA ---WQRALDYLSAISELNYMTQIVIMLYEDNTQDPLSEE---RFHVELHFSPGVKGV--- PPIP5K2_HsapP165_AA ---WKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEE---RFHVELHFSPGAKGC--- *: *::::. ::* . . : :*.* VIP1_ScerP049_AA ----------------------DPLDVQLDD----------------------------R PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA EKERIYETRFNLSTNPKPATSSRSSGRESRDTNDS------------------------A PPIP5K_AqueP197_AA -----------------------------------------------------------R l(1)G0196_DmelP118_AA VQ-KNLPPGPGFRPHSHGDNACNVSLQSSDESNPARIEEENDSNSGEEREGKKRGTSGQR PPIP5K_SpurP177_AA EDDENHPGCCPFRSVHNSGNASPYENNSEEDEPSSCIDSSED-----------------D PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA EEEGSAPAGCGFRPASSENEEMKTNQGSMENLCPGKASDEPD-----------------R PPIP5K2_HsapP165_AA EEDKNLPSGYGYRPASRENEGRRPFKIDNDDEPHTSKRDEVD-----------------R VIP1_ScerP049_AA HYISCIPKISLTKHLDMDYVQQKLR----------------------------------- PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA SSSTEGRRPSIEKVVTVVTPTQLSTPSVTNDDLSISS----------------------- PPIP5K_AqueP197_AA KRLLKGEPISENVSLTKLKKMP-------------------------------------- l(1)G0196_DmelP118_AA STDRSAERISPAFGFNRLELRSKQFKSKPIPIGAHHTVSGHEAMDLAKRLNEELASHQQQ PPIP5K_SpurP177_AA C---SDHKAQKGEEQDKVTPLLKV--AAKDKKLGGGATVAPGGI---------IGGKPFL PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA A-LQTSPQPPEGPGLPRRSPLIRNRKAGSMEVLSETSSSRP------------------- PPIP5K2_HsapP165_AA AVILFKPMVSEPIHIHRKSPLPRSRKTATNDEESPLSVSSPEGTGTWLHYTSGVGTGRRR VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA ---------------------------------------------------NAESTAAES PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA QNQQLRPISPDIRAVTPDCEPRSRSFEQRPTSGVCAKEPVSSPDFGDNSRTRSSEFGETC PPIP5K_SpurP177_AA RIQPIKINEP---SRAAG---------------------------------QSEPVGTPP PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA --GGYRLFSS---SRPPTEM-------------------------------KQSGLGSQC PPIP5K2_HsapP165_AA RRSGEQITSS---PVSPKSLAFTSSIFGSWQQVVSENANYLRTPRTLVEQKQNPTVGSHC VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA TGLVNTTTKTHNDSEDDLNDVESVNLVALDELNN---------------TTKAMADDGKT PPIP5K_AqueP197_AA --LVDTPSTGGGGNNSQ------------------------------------------- l(1)G0196_DmelP118_AA HARVGTASNSDGGGSHPRADHRTAFQIRVTNSLS--------------------FFKIDS PPIP5K_SpurP177_AA SSLLSAGLDDLMGGVAMKSNTGDDHLKVYVPT---------------------------- PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA TGLFSTTVLGGSSSAPNLQDYARSHGKKLPPASLKHRDELLDDQHPVVRLLRSFSSDCTG PPIP5K2_HsapP165_AA AGLFSTSVLGGSSSAPNLQDYARTHRKKLTSSGC------------------IDDATRGS VIP1_ScerP049_AA -------------------------------------------NKFTRVIMPPKFTPVNI PPIP5K_MbreP119_AA ----------------------------------------EDSEASAATNHDVELAPLRI F46F11.1_CeleP088_AA AKRQRSVTGAEKSMEEGDKPHGEW-----------------KGNGVAKSGSQISVGSNEM PPIP5K_AqueP197_AA --------------------------------------------------------PLRR l(1)G0196_DmelP118_AA STNELPLSDIDFSLHPPTPQCGPLSHKRFHILTMRRMESCDDGAELEQVRHLPQISPMAT PPIP5K_SpurP177_AA -QPTLPGVKSAPELHDPN-----WYFN-DDILMRRASTYSAAHQGLEHHIQVTSIRPLET PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA GRPVSLDATLAHHLHQCS-----YHLRLFRNWLRSGQDDPECLYGFEGCSMVPTIYPLET PPIP5K2_HsapP165_AA AVKRFSISFARHPTNEHLHLYRCWSVSSVEFL---------GSSGFELYSMVPSICPLET VIP1_ScerP049_AA TSPNLSFQKRKTRRKSVSVEKLKRP----------------------------------- PPIP5K_MbreP119_AA LHTGMTLEQVERFFQSLPSRVTTPTVSESA------------------------------ F46F11.1_CeleP088_AA ESNNESMETVGGGKGQWVKDLLDQTKRAMAMN-----------------------SIREV PPIP5K_AqueP197_AA RSAQSSSAAAGGIVNHIHANHVRIN----------------------------------- l(1)G0196_DmelP118_AA NERPLSSCNCSSSAAQAHSHSKSLMDLAQAVVMTSPQETGPNSEQGCDPTTAADVSVSSF PPIP5K_SpurP177_AA LHNSLSLRQVDEFLARITRDGAATPECQTPRS---------------------SMHLNTY PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA LHNALSLRQVSEFLSRVCQRHTDAQAQASAALFDSMHSS--------------QASDNPF PPIP5K2_HsapP165_AA LHNALSLKQVDEFLASIASPSSDVPRKTAEISSTALRSS---------PIMRKKVSLNTY VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA EPPIVIPTPV----------------------------PSTTTAVVEDEASERQSRSRRY PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA DDDFQLSSSAPAILMSAHFGNRPVVASLSSMVHVTTSPSASTLQLCRDKDKALASGTSSA PPIP5K_SpurP177_AA TPQRVKPSSL----------------------------------------NTRESDGSSY PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA SPPRTLHSPP----------------------------------------LQLQQRSEK- PPIP5K2_HsapP165_AA TPAKILPTPP-------------------------------------------------- VIP1_ScerP049_AA ------------ASSGSSSSTSVNKTLD-------------------------------- PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA FPYRFKHHTAQLLTGMSGGGVHMQNRLISTDVLTGKFGDHDNKKNSRKDFGAGTAVLSTA PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA HSKATSNSCGQLSMAG-SAPVVTENPFRFTVSSLGSAATNTACFVGSFEPIEEQITSIVE PPIP5K_SpurP177_AA YSRSASNPSSNVSSALPSPTESSAKNFDFSLFLESMKSQRVGRESESGQDESDRPEDYFA PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA PPWYSSGPSSTVSSAGPSSPTTVDGNSQFGFSDQPSLNSHVAEEHQGLGLLQETPGSGAQ PPIP5K2_HsapP165_AA ATLKSTKASSKPATSGPSSAVVPNTSSRKKNITSKTETHEHKKNTGKKK----------- VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA VIARSSSAPRLMTYESEDFSVGE------------------------------------- PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA VDSKPLQPEPQVVYNLPTVLITGTASSSELSTKLNSNILPTVTNAFSAIDTEINDEIGIS PPIP5K_SpurP177_AA SDEAQHDDAKDEIHLMS------------------------------------------- PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA ELSIEGEQELFEPNQSPQVPPMETSQPYE------------------------------- PPIP5K2_HsapP165_AA ------------------------------------------------------------ VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA ---------IKRFWPPLRSLETLHDSINLSQFDGFLERLIKGALTPLPSPPKTPL----- PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA KEVGIGTIRITNTHTPCNKATVTRPDTKIAITTDPQTVTATETAEDTSMDIQPKICIGKC PPIP5K_SpurP177_AA ---------MPSLDDDLVIGSVSCGCKSQTFSSSAMSCTTTCTTTETTTKWKGPE----- PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA -EVSQPCQEVPDISQPCQDISEALSQPCQKVPDISQQCQENHDNGNHTCQEVPHI----- PPIP5K2_HsapP165_AA ------------------------------------------------------------ VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA ------------------------------------------------------------ PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA APGLLTPTVTTTDILKGIRDIAPTATQTSPPTFTPSTTTTTGAAAALFDNTATMSSNRPF PPIP5K_SpurP177_AA ------------------------------------------------------------ PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA ------------------------------------------------------------ PPIP5K2_HsapP165_AA ------------------------------------------------------------ VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA --------------------------------------------------------PSAL PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA TNQFQSIDPTSNDAPHQHHVHQHQYQHHRKTTTTIINNTLNENHTTATITNNTTTTPSCC PPIP5K_SpurP177_AA -------------------------------------------------------IPTTL PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA -------------------------------------------------------SQPCQ PPIP5K2_HsapP165_AA ------------------------------------------------------------ VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA SCDAINKTPTQDEVEKVIGKLAPTSSTD-------------------------------- PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA TKTIATDSQVSVSVSASVSSANASTSSRRQRHSIAGQMSYMKMLGFGGFSKKMATSANSL PPIP5K_SpurP177_AA DCGESVDPQEDTLCSGGDGNGGEVTEEEVSTPC--------------------------- PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA KSSQLCQKVSEEVCQLCLENSEEVSQPCQGVSVEVGKLVHKFHVGVGSLVQETLVEV--- PPIP5K2_HsapP165_AA ------------------------------------------------------------ VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA ------------------------------------------------------------ PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA FSTAVISGSSSAPNLRDMITVSSSGFGDVPPIRPLETLHNALSLRKLDSFLQDMILAQIF PPIP5K_SpurP177_AA ------------------------------------------------------------ PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA ------------------------------------------------------------ PPIP5K2_HsapP165_AA ------------------------------------------------------------ VIP1_ScerP049_AA ------------------------------------------------------------ PPIP5K_MbreP119_AA ------------------------------------------------------------ F46F11.1_CeleP088_AA ------------------------------------------------------------ PPIP5K_AqueP197_AA ------------------------------------------------------------ l(1)G0196_DmelP118_AA KTPTGSPPRGFSKNTLPAVSSMTLTASNQTEVVEHEPISTTVTPTFDRRGSESGSTADAH PPIP5K_SpurP177_AA -------------------------------ASTSSNASQPGATAFEFPAEDTVEDLNKE PPIP5K_NvecP134_AA ------------------------------------------------------------ PPIP5K1_HsapP164_AA ----GSPAEEIPEEVIQPYQEFSVEVGRLAQETSAINLLSQGIPEIDKPSQEFPEEIDLQ PPIP5K2_HsapP165_AA ------------------------------------------------------------ VIP1_ScerP049_AA ------------------------------------ PPIP5K_MbreP119_AA ------------------------------------ F46F11.1_CeleP088_AA ------------------------------------ PPIP5K_AqueP197_AA ------------------------------------ l(1)G0196_DmelP118_AA LRLLSESQCPNLDDSNTELRESLAGKMEQYPTEPSI PPIP5K_SpurP177_AA QDS--------------------------------- PPIP5K_NvecP134_AA ------------------------------------ PPIP5K1_HsapP164_AA AQEVPEEIN--------------------------- PPIP5K2_HsapP165_AA ------------------------------------