MUSCLE (3.8) multiple sequence alignment PTC4_ScerP005_AA_26-370 GIVPR--------------FYNCVGSMQGYRLTQEDAHLIRNENSVVYVRFFNPFIDKYE PPM1A-4_MbreP131_AA_127-512 -FKSQAEL---------LPVRAGVETWSGRKNDNEDRYD--VAMSMG---------AL-- PTC3_ScerP002_AA_2-293 QILSNPIIDKEHHSGTDCLTAFGLCAMQGWRMSMEDAHIVEPNLLAE---------SDEE PTC2_ScerP024_AA_2-292 QILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTK---------SDKD PPM1A-1_MbreP128_AA_19-302 -FLPSPKTDITSMDQRTADQKFGLAYMQGWRAHMEDAHI--TQPELP---------G-LP PPM1A-2_MbreP129_AA_15-291 -AATLP-----------NGLSYALSSMQGWRIHMEDAHA--VSADLP---------N-LP PPM1A-3_MbreP130_AA_3-293 -FLDKPKYEKETHHNQGNNLIWALSSMQGWRVEMEDAHQ--AVTDIP---------E-LP PPM1N_HsapP176_AA_61-328 ----------------SGGLRFGASAAQGWRARMEDAHC--TWLSLP---------GLPP ppm-1_CeleP156_AA_85-382 AFLDKPKTDKTNVHGEGNGIRYGMSSMQGWRICMEDSHIAEAIMSQS---------SPYK PPM1A_AqueP207_AA_3-294 -FLEKPKTDKVTSSGEGYGIRYAVSAMQGWRMEMEDSHI--CDT------------DFIK CG6036_DmelP128_AA_8-285 --LEKPETEKQAQEGHGNGLRYCVSSMQGWRLEMEDSHS--AACRLK---------DPFA PPM1A_NvecP142_AA_3-296 -FLDKPRTEKETKTGEGNGLRYGLAAMQGWRVEMEDAHT--AVIGLS---------DHLK alph_DmelP127_AA_3-286 -FLDKPKTAKHNDEGEGNKLLFGVSSMQGWRSEMEDAYY--ARAGLG---------DALP PPM1A_SpurP184_AA_3-300 -FLEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHS--AVTGLP---------HGLK PPM1B_HsapP175_AA_2-298 AFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHT--AVVGIP---------HGLE PPM1A_HsapP174_AA_75-367 AFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHT--AVIGLP---------SGLE .* . ** : PTC4_ScerP005_AA_26-370 TLSLNVFAVFDGHGGDDCSKFLSGGRHHRDGNGSSNGNGEPNAGLIKWIAYSFE------ PPM1A-4_MbreP131_AA_127-512 -GRL--FAVYDGHAGSECADY--VKKC-----------------LPGNIVGGYRGGVVGC PTC3_ScerP002_AA_2-293 HLAF--YGIFDGHGGSSVAEF--CGSK-----------------MISILKK--------- PTC2_ScerP024_AA_2-292 HIAF--YGIFDGHGGAKVAEY--CGNK-----------------IVEILQE--------- PPM1A-1_MbreP128_AA_19-302 GWSF--YSVIDGHAGAEVAHY--SEDH-----------------LLASVLY--------- PPM1A-2_MbreP129_AA_15-291 NGAL--FAVFDGHGGKTVSTT--AGEI-----------------FIQAITS--------- PPM1A-3_MbreP130_AA_3-293 GGSF--FAVFDGHGGDTVSKI--CGTD-----------------SLKAILE--------- PPM1N_HsapP176_AA_61-328 GWAL--FAVLDGHGGARAARF--GARH-----------------LPGHVLQ--------- ppm-1_CeleP156_AA_85-382 DWSF--FAVFDGHAGHHIANR--ASSQ-----------------LLEHLIS--------- PPM1A_AqueP207_AA_3-294 NWSF--FGVFDGHAGPKVSQY--CSDH-----------------ILRIML---------- CG6036_DmelP128_AA_8-285 TWSY--FAVFDGHAGSQISLH--CAEH-----------------LMSTILE--------- PPM1A_NvecP142_AA_3-296 DWSF--FAVFDGHAGENVSKY--CSSN-----------------LHETLLK--------- alph_DmelP127_AA_3-286 DWSF--FAVFDGHAGCKVSEH--CAKH-----------------LLESIIS--------- PPM1A_SpurP184_AA_3-300 DWSF--FAVFDGHAGSKVAKH--CSEH-----------------ILHEITS--------- PPM1B_HsapP175_AA_2-298 DWSF--FAVYDGHAGSRVANY--CSTH-----------------LLEHITT--------- PPM1A_HsapP174_AA_75-367 SWSF--FAVYDGHAGSQVAKY--CCEH-----------------LLDHITN--------- :.: ***.* : : PTC4_ScerP005_AA_26-370 --------------NHHYTSTTNNDSSKFKRSFNTLEGLVSQ------------------ PPM1A-4_MbreP131_AA_127-512 EGTDAELQELQSQMSEAQQSLVELTAALEATPDDESLQQMQQQLLAQHEAKSGLSTDYQT PTC3_ScerP002_AA_2-293 --------------QESFK-----------------SGMLEQ------------------ PTC2_ScerP024_AA_2-292 --------------QKSFH-----------------EGNLPR------------------ PPM1A-1_MbreP128_AA_19-302 --------------E--------------LLPVKDSLHAISD------------------ PPM1A-2_MbreP129_AA_15-291 --------------TEAYT------------KGDKSAANLEQ------------------ PPM1A-3_MbreP130_AA_3-293 --------------TDIFK----------AAEDKLNPDMLKD------------------ PPM1N_HsapP176_AA_61-328 --------------E--------------LGPEPSEPEGVRE------------------ ppm-1_CeleP156_AA_85-382 --------------SEEFREMTKTLEENNGVLTDSTLKLLEK------------------ PPM1A_AqueP207_AA_3-294 ---------------DDLKASLDE-----CKSTEEPKERIKQ------------------ CG6036_DmelP128_AA_8-285 --------------SESFS-----------------KHKYEA------------------ PPM1A_NvecP142_AA_3-296 --------------HQSFEAAIK------ESSDSPDLDQLRS------------------ alph_DmelP127_AA_3-286 --------------TEEFI----------------GGDHVK------------------- PPM1A_SpurP184_AA_3-300 --------------NPEFLGSPKV-----DGKLNPSTDAVKE------------------ PPM1B_HsapP175_AA_2-298 --------------NEDFRAAGKS-----GSALELSVENVKN------------------ PPM1A_HsapP174_AA_75-367 --------------NQDFK----------GSAGAPSVENVKN------------------ PTC4_ScerP005_AA_26-370 ----IFKDAFILQDEELYRHFANSSCG-----STAVVACII-----NEES--LYVANCGD PPM1A-4_MbreP131_AA_127-512 AVLKCVKDGYKCTDKNWLSMAIKKKKQG----GSTSLTIMLNGSSTTNAH--LIIANLGD PTC3_ScerP002_AA_2-293 ----CLIDTFLATDVELLKD-EKLKDDHS---GCTATVILV-----SQLKKLLICANSGD PTC2_ScerP024_AA_2-292 ----ALIDTFINTDVKLLQD-PVMKEDHS---GCTATSILV-----SKSQNLLVCGNAGD PPM1A-1_MbreP128_AA_19-302 ----AMHRAFLRHDRALFAD-NKVRLDNS---GGTCTSVLV-----SPTH--YIFVNLGD PPM1A-2_MbreP129_AA_15-291 ----VLSKGLFELDEAIKEKHPQLKAGHDRS-GSTVICGFV-----TETS--VVLCNCGD PPM1A-3_MbreP130_AA_3-293 ----AFRQGLLDLDASIRATNSDLDSCADRS-GSTAVGVIV-----TPTH--VIFGNCGD PPM1N_HsapP176_AA_61-328 ----ALRRAFLSADERLRSLWPRVETG-----GCTAVVLLV-----SPRF--LYLAHCGD ppm-1_CeleP156_AA_85-382 ----GIKKGFLSFDEISKTS-NDISKS-----GCTAVCAIV-----TPTH--FIIGNLGD PPM1A_AqueP207_AA_3-294 ----AIYDGFLKLDSKIRED-PTWANGEDHS-GTTAITVMI-----SPTH--IYWANCGD CG6036_DmelP128_AA_8-285 ----GIREGFLQLDEDMRKL-YHDQQG-----GSTAICVFV-----SPDK--IYLVNCGD PPM1A_NvecP142_AA_3-296 ----GLRDAFLELDSTMQKL-PKWSSGEDKS-GSTAIALLV-----TPKY--YIFANCGD alph_DmelP127_AA_3-286 ----GIRTGFLRIDEVMREL-PEFTRESEKCGGTTAVCAFV-----GLTQ--VYIANCGD PPM1A_SpurP184_AA_3-300 ----GIRTGFLSIDSKMRTD-FARTDSSDKS-GSTAVGVII-----SPKH--LFFANCGD PPM1B_HsapP175_AA_2-298 ----GIRTGFLKIDEYMRNF-SDLRNGMDRS-GSTAVGVMI-----SPKH--IYFINCGD PPM1A_HsapP174_AA_75-367 ----GIRTGFLEIDEHMRVM-SEKKHGADRS-GSTAVGVLI-----SPQH--TYFINCGD . * . : :: : ** PTC4_ScerP005_AA_26-370 SRCILSSKS-NGIKTMSFDHKPQHIGELIRINDNGGTVS----LGRVGGV---------- PPM1A-4_MbreP131_AA_127-512 CRAVMCRGT--RAHRLTQDHKPDRPDEKKRIQQAGGHVVNVMGVSRVMGAREDREPRQAL PTC3_ScerP002_AA_2-293 SRTVLSTGG--NSKAMSFDHKPTLLSEKSRIVAADGFVE----MDRVNGN---------- PTC2_ScerP024_AA_2-292 SRTVLATDG--NAKALSYDHKPTLASEKSRIVAADGFVE----MDRVNGN---------- PPM1A-1_MbreP128_AA_19-302 SRSLLCRGG--KLAFQTRDHKPILPQERTRIRNAGGFVI----NGRVDGG---------- PPM1A-2_MbreP129_AA_15-291 SRAVLVSDG--KVKFATSDHKPSDEIETQRIKNAGGFIE----MGRVCGN---------- PPM1A-3_MbreP130_AA_3-293 SRAFICRNG--NVVFATDDHKPTNEGEVARIKAADGDVS----MGRVCGN---------- PPM1N_HsapP176_AA_61-328 SRAVLSRAG--AVAFSTEDHRPLRPRERERIHAAGGTIR----RRRVEGS---------- ppm-1_CeleP156_AA_85-382 SRAVVAGK---NEIFGTEDHKPYLEKERKRIEGAGGSVM----IQRINGS---------- PPM1A_AqueP207_AA_3-294 SRGFLCSDG--KVKFATEDHKPYLAREKERIEKAGGSVI----MQRVNGS---------- CG6036_DmelP128_AA_8-285 SRAVISRNG--AAVISTIDHKPFSPKEQERIQNAGGSVM----IKRINGT---------- PPM1A_NvecP142_AA_3-296 SRGILSHNG--EVIYNTVDHKPGNPDEKTRIENAGGSVM----IQRVNGA---------- alph_DmelP127_AA_3-286 SRAVLCRQG--VPVFATQDHKPILPEEKERIYNAGGSVM----IKRVNGT---------- PPM1A_SpurP184_AA_3-300 SRSVLSRKGEDKPTFSTEDHKPGKPKEMKRIEDAGGSVM----IERVNGS---------- PPM1B_HsapP175_AA_2-298 SRAVLYRNG--QVCFSTQDHKPCNPREKERIQNAGGSVM----IQRVNGS---------- PPM1A_HsapP174_AA_75-367 SRGLLCRNR--KVHFFTQDHKPSNPLEKERIQNAGGSVM----IQRVNGS---------- .* .: : **.* * ** .* : *: * PTC4_ScerP005_AA_26-370 -LALSRAFSDFQFKRGVTYPHRRTKLTNITQNLTYGTPPQEAQVTVEPDVLMHKIDYSKD PPM1A-4_MbreP131_AA_127-512 MLAVSRSFGDYALKT------------------------PKLLVSHVPEVSI-ERIEDKD PTC3_ScerP002_AA_2-293 -LALSRAIGDFEFKS------------------NTKLGPHEQVVTCVPDIICHNLNYDED PTC2_ScerP024_AA_2-292 -LALSRAIGDFEFKS------------------NPKLGPEEQIVTCVPDILEHSLDYDRD PPM1A-1_MbreP128_AA_19-302 -LAISRAFGDFDYKR------------------NPQLGALEQKVVADPDVTLVERDLEHD PPM1A-2_MbreP129_AA_15-291 -LAVSRAIGDYEYKD------------------RPDLKPEEQKVTALSDTTSISRTPKDE PPM1A-3_MbreP130_AA_3-293 -LAVSRSLGDYFYKD------------------MPDLDATAQKISPEADMTVIERNPEDQ PPM1N_HsapP176_AA_61-328 -LAVSRALGDFTYKE------------------APGRPPELQLVSAEPEVAALARQAEDE ppm-1_CeleP156_AA_85-382 -LAVSRAFGDYEYKD------------------DPRLPADQQLVSPEPDVYIRERNLEND PPM1A_AqueP207_AA_3-294 -LAVSRALGDFDYKR------------------NNSIPAKEQLVSPEPEIDILPRDSEND CG6036_DmelP128_AA_8-285 -LAVSRAFGDYDFKN------------------DGSKSPVDQMVSPEPDIIVCNRSEHDE PPM1A_NvecP142_AA_3-296 -LAVSRALGDFEYKL------------------DSSLHATKQLVSPEPDIFFQSRSDQDE alph_DmelP127_AA_3-286 -LAVSRALGDYDFKN------------------VKEKGQCEQLVSPEPEIFCQSRQDSDE PPM1A_SpurP184_AA_3-300 -LAVSRALGDYDYKN------------------NPDKPPTEQLVSPEPEVTVFERTDEEE PPM1B_HsapP175_AA_2-298 -LAVSRALGDYDYKC------------------VDGKGPTEQLVSPEPEVYEILRAEEDE PPM1A_HsapP174_AA_75-367 -LAVSRALGDFDYKC------------------VHGKGPTEQLVSPEPEVHDIERSEEDD **:**::.*: * : .: : PTC4_ScerP005_AA_26-370 EFLVLACDGIWDIYNNKQLIHFIKYHLVSG-TKLDTIITKLLDH---------------- PPM1A-4_MbreP131_AA_127-512 YFFVIACDGIWDVLSDQEVVDLARKHYGQAQDGMMTLPSYALAQEGSGVGLCLFQGLGFS PTC3_ScerP002_AA_2-293 EFVILACDGIWDCLTSQECVDLVHYGISQGNMTLSDISSRIVDV---------------- PTC2_ScerP024_AA_2-292 EFVILACDGIWDCLTSQDCVDLVHLGLREG-KTLNEISSRIIDV---------------- PPM1A-1_MbreP128_AA_19-302 DFLLLCCDGIFDVMSNATAIKFVATKLRRSPDNPKAVCQALLKR---------------- PPM1A-2_MbreP129_AA_15-291 -FLVLACDGIWDVLTNEGVQLVVNFFLERG-YDAERIADLLLDY---------------- PPM1A-3_MbreP130_AA_3-293 -FMLIACDGIYDVLTNANAAAFITNQLKAG-YKAEEVVERLLDY---------------- PPM1N_HsapP176_AA_61-328 -FMLLASDGVWDTVSGAALAGLVASRLRLG-LAPELLCAQLLDT---------------- ppm-1_CeleP156_AA_85-382 QFMVVACDGIYDVMTNEELAEFVKDRLSVH-SDLREVCDDVLDE---------------- PPM1A_AqueP207_AA_3-294 EFLLLACDGIYDVMSNEEVMSYVRRQLELT-ANLEKICNDLIDL---------------- CG6036_DmelP128_AA_8-285 -FIVVACDGIWDVMTSSEVCEFIRSRLLVT-YDLPMIVNSVLDI---------------- PPM1A_NvecP142_AA_3-296 -FIVLACDGVWDVMTNDEVGAFVRSRLQIT-DDLQRVSCELLDT---------------- alph_DmelP127_AA_3-286 -FLVLACDGIWDVMSNEDVCSFIHSRMRVT-SNLVSIANQVVDT---------------- PPM1A_SpurP184_AA_3-300 -FIILACDGIWDVMSNEELCQFIRSRLAIT-DNLEEICNQVIET---------------- PPM1B_HsapP175_AA_2-298 -FIILACDGIWDVMSNEELCEYVKSRLEVS-DDLENVCNWVVDT---------------- PPM1A_HsapP174_AA_75-367 QFIILACDGIWDVMGNEELCDFVRSRLEVT-DDLEKVCNEVVDT---------------- *.::..**::* . : : PTC4_ScerP005_AA_26-370 -------------------------GIAQANSNTGVGFDNMTAIIVVLNR- PPM1A-4_MbreP131_AA_127-512 KCLKDQPVFCLFVPCVAAARAIVRKAYEAGSG------DNLTALVVEFA-- PTC3_ScerP002_AA_2-293 -------------------------CCSPTTEGSGIGCDNMSISIVAL--- PTC2_ScerP024_AA_2-292 -------------------------CCAPTTEGTGIGCDNMSIVVVAL--- PPM1A-1_MbreP128_AA_19-302 -------------------------CLELGSR------DNMSACLVVFN-- PPM1A-2_MbreP129_AA_15-291 -------------------------CLELGSK------DNMSALLILFPG- PPM1A-3_MbreP130_AA_3-293 -------------------------CLHLDSK------DNMSAILVLFENA PPM1N_HsapP176_AA_61-328 -------------------------CLCKGSL------DNMTCILVCFPG- ppm-1_CeleP156_AA_85-382 -------------------------CLVKGSR------DNMTMVVVCFP-- PPM1A_AqueP207_AA_3-294 -------------------------CLNKNSR------DNMSVVLVVFPNA CG6036_DmelP128_AA_8-285 -------------------------CLHKGSR------DNMTLLLLLLPG- PPM1A_NvecP142_AA_3-296 -------------------------CLTKGSR------DNMSVIIISLPG- alph_DmelP127_AA_3-286 -------------------------CLHKGSR------DNMSIIIIAFPG- PPM1A_SpurP184_AA_3-300 -------------------------CLQKGSR------DNMSIVIVLFQNA PPM1B_HsapP175_AA_2-298 -------------------------CLHKGSR------DNMSIVLVCFSNA PPM1A_HsapP174_AA_75-367 -------------------------CLYKGSR------DNMSVILICFPNA . **:: :: :