MUSCLE (3.8) multiple sequence alignment rdgC_DmelP103_AA MLRSCV------CLRTDDDGKRRSSSVEDASSCRSSEIERVGASMQTLGPNGQPQSSAAQ pef-1_CeleP136_AA --MGCGPSSGRQNPSTELKKSTRATTTTTSSSQRNNYNDNNQNTSSSSGNKKESSSSSKQ PPEF1_HsapP144_AA --MGCS------------------------------------------------------ PPEF2_HsapP145_AA --MGSG------------------------------------------------------ PPP7C-b_SpurP164_AA --MGCG------------------------------------------------------ PPP7C_NvecP124_AA --MGCG------------------------------------------------------ .. rdgC_DmelP103_AA TSTRASSLLQLFQRRGWCKHFRKPLRGMSASRAEKTIRAAIFIQKWYRRHQARREMQRRC pef-1_CeleP136_AA HSSKKS------------KKSNSKKNRSPSPQPQLTIKSAILIQKWYRRCEARLEARRRA PPEF1_HsapP144_AA SSSTKT------------------------RRSDTSLRAALIIQNWYRGYKARLKARQHY PPEF2_HsapP145_AA TSTQHH------------FA---------FQNAERAFKAAALIQRWYRRYVARLEMRRRC PPP7C-b_SpurP164_AA NSMHAH------------SE---------MGKSERSLKAALLIQKWYRRYQARLEARRRC PPP7C_NvecP124_AA TSVDAY------------KEYDGHKNSLSLSKSEKALRSAVLIQNWFRRYRARLEARRRC * ..: ::.:* :**.*:* ** : ... rdgC_DmelP103_AA NWQIFQNLEYASEQDQAELYKFFNDLIKHMPQAAGRKN-------QY--------QGSAH pef-1_CeleP136_AA TWQIFTALEYAGEQDQLKLYDFFADVIRAMAEENGKGGVENGRNSPLMSALSHYAKPSLM PPEF1_HsapP144_AA ALTIFQSIEYADEQGQMQLSTFFSFMLENYTHIHKEEL-------ELRN------QSLES PPEF2_HsapP145_AA TWSIFQSIEYAGQQDQVKLHDFFSYLMDHFIPSSHNDR--DFLTRIFTE------DRFAQ PPP7C-b_SpurP164_AA TWKIFQTIEYAGEQDQLKLYNFFNSMMQTVSEDDSKSK--------YII------QGSNE PPP7C_NvecP124_AA TWKIFQSIEYSGEQDQLKLFNFFTDMLTHVQPDNTGASRANIIEDTLSR------NGSAS ** :**:.:*.* :* ** :: . rdgC_DmelP103_AA VSVLDDKDDLV--------EEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVA pef-1_CeleP136_AA DSEGETVKKMLEDTSPTNVDIDRNYKGPTLSLPLDKPQVAKMIEAFKVNK--VLHPKYVL PPEF1_HsapP144_AA EQDMRDRWDYV-----DSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQ--ILHAHYVL PPEF2_HsapP145_AA DSEMKKCSDYE------SIEVPDSYTGPRLSFPLLPDHATALVEAFRLKQ--QLHARYVL PPP7C-b_SpurP164_AA GKTRDSDEDIY-----SDMEVEEDYDGPHLAFPLSLDQVEKMMEDFKEQK--LLHSKYVL PPP7C_NvecP124_AA STSSKSSTTLEAATDPSDIKVEPTYTGHVVKLPITLMSVRNIIEQCKLNK--LVHAKYVL . . : :*: ::: . :. :*..** rdgC_DmelP103_AA LILREAAKSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNG pef-1_CeleP136_AA MILHEARKIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNG PPEF1_HsapP144_AA EVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNG PPEF2_HsapP145_AA NLLYETKKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNG PPP7C-b_SpurP164_AA MVLRETEKVMKTKKNINRATTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENPYIFNG PPP7C_NvecP124_AA LILREARERFRALPNVIRVTTRIAKQMTICGDLHGKLDDLFMIFHKNGLPSPENPYIFNG :* *: : : .. * ::::*:****** ::** .:::*** ** ..*:*** rdgC_DmelP103_AA DFVDRGKRGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKYPRNHKRI pef-1_CeleP136_AA DFVDRGGQSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKYKDLSTPI PPEF1_HsapP144_AA DFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKYKLHGKRI PPEF2_HsapP145_AA DFVDRGKDSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKYKVHGKEI PPP7C-b_SpurP164_AA DYVDRGMHSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKY---GAQI PPP7C_NvecP124_AA DLVDRGPRSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKYKDHASKI * **** .:*: :* : * ..:******* ::* **** .*: ** * rdgC_DmelP103_AA LAFIDEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILR---------- pef-1_CeleP136_AA TRLLEDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLR---------- PPEF1_HsapP144_AA LQILEEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLI---------- PPEF2_HsapP145_AA LRTLQDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSEKQ PPP7C-b_SpurP164_AA IGQFQDLFAWLPLATLIDSKILICHGGISDKTDLTFLDNIARHKYLSVLK---------- PPP7C_NvecP124_AA IRLFEDIFGWLPLATIVNNKIFVAHGGISNITDLDIIERIDRHKYVSVLK---------- :::.: ***:.:::: ::: ***.*: *.: : : * . * : rdgC_DmelP103_AA -----------------------------PPLTDG------------------------- pef-1_CeleP136_AA -----------------------------PPVNKG------------------------- PPEF1_HsapP144_AA -----------------------------PPTETNRDHDTDSKHNKVGVTFNAHG----- PPEF2_HsapP145_AA MEEKRRANQKSSAQGPIPWFLPESRSLPSSPLRLGSYKAQKTSRSSSIPCSGSLDGRELS PPP7C-b_SpurP164_AA -----------------------------PPLKEGAEE---------------------- PPP7C_NvecP124_AA -----------------------------PPN---------------------------- .* rdgC_DmelP103_AA ------------------------------EPLD-------------KTEWQQIFDIMWS pef-1_CeleP136_AA ---------------------MESEKENSAVNVD---------------EWKQMLDIMWS PPEF1_HsapP144_AA ---------------------RIKTNGSPTEHLT-------------EHEWEQIIDILWS PPEF2_HsapP145_AA RQVRSSVELELERCRQQAGLLVTGEKEEPSRSASEADSEAGELRKPTQEEWRQVVDILWS PPP7C-b_SpurP164_AA ---------------------LTGEEEDLSLKID-------------LSEWRQILDILWS PPP7C_NvecP124_AA ---------------------IVKDNPSLSS----------------LKEWRQVLDLLWS ** *:.*::** rdgC_DmelP103_AA DPQATMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIF pef-1_CeleP136_AA DPKQNKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVF PPEF1_HsapP144_AA DPRGKNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIF PPEF2_HsapP145_AA DPMAQEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIF PPP7C-b_SpurP164_AA DPRSQDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVF PPP7C_NvecP124_AA DPKPTPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIF ** ** .*. **.* :**.*:* ..* .: : ::****** :*:* *. . :*:* rdgC_DmelP103_AA SASNYYAIGSNKGAYIRL-NNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVR pef-1_CeleP136_AA SASNYYETGSNRGAYVKFIGKSKQPHFVQYMAS-KTHRKSTLRERLGVVEESAVKELKEK PPEF1_HsapP144_AA SASNYYEEGSNRGAYIKL-CSGTTPRFFQYQVT-KATCFQPLRQRVDTMENSAIKILRER PPEF2_HsapP145_AA SASNYYEVGSNRGAYVKL-GPALTPHIVQYQAN-KVTHTLTMRQRISRVEESALRALREK PPP7C-b_SpurP164_AA SASNYYEEGSNRGAYIKF-GTDLKPRCFQYQTSAKNTKKMTMRQKVSIVEESALRDLREK PPP7C_NvecP124_AA SASNYYEQGSNRGAYMKI-GPDMTPYFVQYQVS-RTKKHLTLKQRVGIVEESAIRELKEK ****** ***.***:.: * .** .:.:.:. :*.**:. * . rdgC_DmelP103_AA MRDHRDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLP------------------- pef-1_CeleP136_AA LSSFHTDLQKEFEIMDIEKSGKLPILKWSDCVERITGLNLP------------------- PPEF1_HsapP144_AA VISRKSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLP------------------- PPEF2_HsapP145_AA LFAHSSDLLSEFKKHDADKVGLITLSDWAAAVESVLHLGLP------------------- PPP7C-b_SpurP164_AA IGANTTYLRQAFQKYDPGNTGFITSTQWARTMEEILDLSIPWRTLKTKPYLSLSLRFHHI PPP7C_NvecP124_AA LYANKSALMEAFTKRDEQHTGYLTCSQWAAAIESTLHLDVP------------------- : * * * * :. *. :* *.:* rdgC_DmelP103_AA ---------------------------WRLLRDKLAPGTDSQK-VNYNRTLDLLDTDVIL pef-1_CeleP136_AA ---------------------------WIALAPKVATLSEDGKYVMYKEDRRIAQVGGTH PPEF1_HsapP144_AA ---------------------------WRSLSSNLVNIDQNGN-VEYMSSFQNIRIEKPV PPEF2_HsapP145_AA ---------------------------WRMLRPQLVNSSADNM-LEYKSWLKNLAKEQLS PPP7C-b_SpurP164_AA NPVGQDYGGDPRPWARTMEEILDLSIPWRTLKTKMCRMNENGL-IEYDSCLEM-ELQYSG PPP7C_NvecP124_AA ---------------------------WNMLRHQLAYVAPDGK-VDYRSCLEQYAIEGKT * * :: . : * rdgC_DmelP103_AA EAEADGMSVMDALYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEM pef-1_CeleP136_AA A-Q--EKDIVESLYRHKSTLETLFRFMDKDNSGQVSMKEFIDACEVLGKYTKRPLQTDYI PPEF1_HsapP144_AA Q-EA-HSTLVETLYRYRSDLEIIFNAIDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQV PPEF2_HsapP145_AA R-ENIQSSLLETLYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCI PPP7C-b_SpurP164_AA E-KG-GPSVTETLYRNKNALETIFRVMDKDHSGCISMEEFQDACQLLSKHIGSNIPPETV PPP7C_NvecP124_AA K-KN-GPSITEALYRNRSNLETIFRLMDKDNSGHVSMEEFQASCRLLNQHSETEIPEDSI : : ::** . * :*. :* *:** :::.** :: : : rdgC_DmelP103_AA LEKCRMMDLNGDGKVDLNEFLEAFRLSDLHRKEQQDENIRRRSTGRPSVAKTATDPVTLL pef-1_CeleP136_AA SQIAESIDFNKDGFIDLNELLEAFRLVDRPLLR--------------------------- PPEF1_HsapP144_AA NKLANIMDLNKDGSIDFNEFLKAFYVVHRY------------EDLMKPDVTNLG------ PPEF2_HsapP145_AA CDLARSIDFNKDGHIDINEFLEAFRLVEKSCPEGDASECPQATNAKDSGCSSPGAH---- PPP7C-b_SpurP164_AA KDMAQSIDINKDGNIDFNEFLEAFRLVDTQDIKLDGQT----SMQNSPAHVANGENNKV- PPP7C_NvecP124_AA QDLARSIDMDKDGYIDFNEFLEAFRLVDVSKSQNGPTHTPR-SSQNSSARSSPVNSIHIT . . :*:: ** :*:**:*:** : rdgC_DmelP103_AA ADKISKNTLVVEHDIDPTDCESKVIDPKKS pef-1_CeleP136_AA ------------------------------ PPEF1_HsapP144_AA ------------------------------ PPEF2_HsapP145_AA ------------------------------ PPP7C-b_SpurP164_AA ------------------------------ PPP7C_NvecP124_AA S-----------------------------