MUSCLE (3.8) multiple sequence alignment TEP1_ScerP061_AA_20-254 ----------------NLMKKILSLPMKKTKNDIG--LRLDISYILVNLIVCSYPVNTYP DDB_G0292920_DdisP043_AA_6-199 ---------------FDYFRTIVSGRKKRFIQD-G--FNLDLSYITERILAMGYPA-DSI DDB_G0275865_DdisP040_AA_14-217 SNELGEEINKQVNSTVLKIRTQVSENNTTIRFK-DGEFDLDLSYITERIIAMSFPSEDTV daf-18_CeleP048_AA_46-221 ----------------HIFRTAVSSNRCRTEYQ-N--IDLDCAYITDRIIAIGYPA-TGI DDB_G0285967_DdisP041_AA_3-195 ------------------VRKMVSKKKRRFEMY-N--FDLDLSYITDRVIAMGFPS-ESL PTEN-1_MbreP028_AA_446-631 ------------------VRQLVSKQKIRFQKD-G--FDLDLTYITPNIVAMGYPA-EGT pten_DdisP044_AA_4-183 ------------------LRVAVSKQKRRYQKN-G--YDLDLAYITDNIVAMGFPS-EKV Pten_DmelP035_AA_11-216 ------------------IRNVVSKKRIRYKEK-G--YDLDLTYINDNIIAMGYPAPDKL PTEN-1_SpurP044_AA_0-152 ---------------------------------------------------MGFPA-ESL PTEN_HsapP064_AA_3-211 -----------------IIKEIVSRNKRRYQED-G--FDLDLTYIYPNIIAMGFPA-ERL PTEN-2_SpurP045_AA_2-176 -----------------------SKKKRRFIDK-G--FDLDLSYIYPNIIAMGFPA-ESL PTEN-2_MbreP029_AA_2-187 ----------------TIAKHLVSKKKRRFMDE-G--FDLDLTFITRNIVAMGFPA-EGR PTEN_AqueP041_AA_5-190 ------------------FRHLVSKRKRRFIAD-G--FDLDMTFIKPNIVAMGFPS-EKL PTEN_NvecP038_AA_1-187 ----------------SYFKQLVSKKKRRFQED-G--FDLDLTYIKPNIVAMGFPS-EKL cnrN_DdisP039_AA_11-189 ---------------------LVSADRHRFKSK-EMDLDLDLSYITDNILAMGFPG-TGL DDB_G0289979_DdisP042_AA_8-194 ------------------VRKTISADKNRYENE-E--YDLDLTYITERVIAMSFPA-DGV .:* TEP1_ScerP061_AA_20-254 --KLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAKFESKDFEIQ DDB_G0292920_DdisP043_AA_6-199 --HKAFRNDINEVYNFFEKYH-SAHWKILNVAMEI---------------SYSTTKV--- DDB_G0275865_DdisP040_AA_14-217 INSTWYRNSRVDVKKMLDKYH-RDHYLIINL-TEK---------------SYDSSFF--- daf-18_CeleP048_AA_46-221 --EANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGY---------------YYDADNF--- DDB_G0285967_DdisP041_AA_3-195 --EGLYRNRMRDVQRFFNTLH-ADHYKVYNLCSER---------------KYEHCRF--- PTEN-1_MbreP028_AA_446-631 --EAVYRNRYEDTLRFLEERH-PGAYRVYNLCSER---------------AYPPSRF--- pten_DdisP044_AA_4-183 --EGVFRNPMKDVQRFLDQYH-KDHFKVYNLCSER---------------VYDHSKF--- Pten_DmelP035_AA_11-216 --EGLFRNRLEDVFKLLEENH-AQHYKIYNLCSER---------------SYDVAKF--- PTEN-1_SpurP044_AA_0-152 --ERMYRNDMEHVVKFLNSHH-QDHYKVYNLCSER---------------NYDTSRF--- PTEN_HsapP064_AA_3-211 --EGVYRNNIDDVVRFLDSKH-KNHYKIYNLCAER---------------HYDTAKF--- PTEN-2_SpurP045_AA_2-176 --EGVYRNKLEVVVKFFNEKH-GERYKVYNLCSER---------------NYDTTKF--- PTEN-2_MbreP029_AA_2-187 --EGIYRNHMRDVKRFFDYRC-KDHYRVYNLCSER---------------DYDPQKF--- PTEN_AqueP041_AA_5-190 --EGVYRNKMSDVQRYFDTHY-TDHYKVYNLCSER---------------FYDPKKF--- PTEN_NvecP038_AA_1-187 --EGVYRNHMDEVYRFLEQKH-KDSYKVYNLCSER---------------QYDPMRF--- cnrN_DdisP039_AA_11-189 --EASWRNSIDDVCELLKQKH-HGKYMIWNL-SER---------------VYDYSKL--- DDB_G0289979_DdisP042_AA_8-194 --ESAYRNSIYDVSKLLNTSH-KDHYLIYNL-SER---------------KYDYSLF--- :** : : *. : . TEP1_ScerP061_AA_20-254 ELRSTLINDGKIPIS-PIDLETRTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIEN DDB_G0292920_DdisP043_AA_6-199 --------GGNVIVM-GFE----------------------DHTPPPFLLLLDIIETMNK DDB_G0275865_DdisP040_AA_14-217 --------GGRVHHI-GCV----------------------DNHSPSLGLLLYAVQVIHK daf-18_CeleP048_AA_46-221 --------DGNVICF-DMT----------------------DHHPPSLELMAPFCREAKE DDB_G0285967_DdisP041_AA_3-195 --------EDRVSEY-PFD----------------------DHCPPTLNIISEFCNDMEM PTEN-1_MbreP028_AA_446-631 --------HNRVGVY-PFD----------------------DHNPAPLPLVLACCADIHA pten_DdisP044_AA_4-183 --------YGRVGYY-PFD----------------------DHNAPQFEMIDAFCRDVDA Pten_DmelP035_AA_11-216 --------RGRVAVY-PFD----------------------DHNPPTIELIQRFCSDVDM PTEN-1_SpurP044_AA_0-152 --------DHRVAHY-PFD----------------------DHNPPRIELIRPFCEDVMQ PTEN_HsapP064_AA_3-211 --------NCRVAQY-PFE----------------------DHNPPQLELIKPFCEDLDQ PTEN-2_SpurP045_AA_2-176 --------YNRVAHY-PFD----------------------DHNPPRLELIKPFCEDLDN PTEN-2_MbreP029_AA_2-187 --------YGRVAKY-PFD----------------------DHNAPPFLLMQPFCEDVHQ PTEN_AqueP041_AA_5-190 --------H-KVTVY-PFD----------------------DHNPPPFELIQPFCEDVDG PTEN_NvecP038_AA_1-187 --------HNRVATY-PFD----------------------DHNAPPFELIKPFCDDVDE cnrN_DdisP039_AA_11-189 --------NNQILEF-PFL----------------------DHHPPPLSLLFEIVNSLSN DDB_G0289979_DdisP042_AA_8-194 --------NGMVLDWCGFP----------------------DHHAPPLGLLFKIVMTIYS : *: .. : :: TEP1_ScerP061_AA_20-254 YLSVSK-NRVAVLHCRMGKGRSGMITVAYLMKYLQCPLG-----------EARLIFMQAR DDB_G0292920_DdisP043_AA_6-199 WLDSDE-QNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLFYSSDTILYNTISFFNQMR DDB_G0275865_DdisP040_AA_14-217 WLSEDP-KNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKE----------EALQLFASQR daf-18_CeleP048_AA_46-221 WLEADD-KHVIAVHCKAGKGRTGVMICALLIYINFYPSPR----------QILDYYSIIR DDB_G0285967_DdisP041_AA_3-195 WLDQNP-ENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGS----------ESMRLFANKR PTEN-1_MbreP028_AA_446-631 WLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGICPDPD----------SAMTMFGAKR pten_DdisP044_AA_4-183 WMKEDS-KNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTE----------DSLRFYAALR Pten_DmelP035_AA_11-216 WLKEDS-SNVVAVHCKAGKGRTGTMICAYLVFSGIKKSAD----------EALAWYDEKR PTEN-1_SpurP044_AA_0-152 WLAEDK-DNVAAIHCKAGKGRTGVMICALLLHQGRCLTAA----------ESMEYYGKIR PTEN_HsapP064_AA_3-211 WLSEDD-NHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQ----------EALDFYGEVR PTEN-2_SpurP045_AA_2-176 WLGADG-QNVAAIHCKAGKGRTGVMICAYMLHRRLYQTAS----------EALDFYASKR PTEN-2_MbreP029_AA_2-187 YLSEDS-RNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTE----------EALEFYGHAR PTEN_AqueP041_AA_5-190 WLKEDN-RNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVK----------DALQFYGEAR PTEN_NvecP038_AA_1-187 WLKASN-LNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTK----------EAMEYYGNAR cnrN_DdisP039_AA_11-189 WLKADA-ENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMD----------DAKNHFAEKR DDB_G0289979_DdisP042_AA_8-194 WLEKDP-MNVVVVHCMAGKGRTGTVISALLQYGGLFEGAS----------DAMRYFAVKR :: . .: :** * **:* : . : . : * TEP1_ScerP061_AA_20-254 FKYGMTNGVTIPSQLRYLRYHEFFITH--------------------------- DDB_G0292920_DdisP043_AA_6-199 ANNSE--CVTVPSQKRYVGYYIQYLRD--------------------------- DDB_G0275865_DdisP040_AA_14-217 TTSKV--GVKVPSQLRYIDYVHQLVTSQ-------------------------- daf-18_CeleP048_AA_46-221 TKNNK--GVTIPSQRRYIY----------------------------------- DDB_G0285967_DdisP041_AA_3-195 THNSK--GVTIPSQIRYVRYFEALLQYGKPIPKPPSITK--------------- PTEN-1_MbreP028_AA_446-631 THNGK--GVTIPSQRRYIRYFHTMLQGDRTV----------------------- pten_DdisP044_AA_4-183 TYNQK--GVTIPSQIRYVGYFGRSIR---------------------------- Pten_DmelP035_AA_11-216 TKDRK--GVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQN--- PTEN-1_SpurP044_AA_0-152 TTDGK--GVTIPSQRRYVQYYGELVKRNT------------------------- PTEN_HsapP064_AA_3-211 TRDKK--GVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTC PTEN-2_SpurP045_AA_2-176 TKNRK--GVTIPSQRRYVEYYGNLIV---------------------------- PTEN-2_MbreP029_AA_2-187 TMNGK--GVTIPSQVRYVHYYGRYVREQRE------------------------ PTEN_AqueP041_AA_5-190 TQNAK--GVTIPSQRRYVQYYGHLIRNNLQYSP--------------------- PTEN_NvecP038_AA_1-187 TRNAK--GVTIPSQRRYVEYYGYLLRNCLTY----------------------- cnrN_DdisP039_AA_11-189 SKMKK--GVTQPSQQRYINYFKEIVSG--------------------------- DDB_G0289979_DdisP042_AA_8-194 SNNNY--GITGPSQIRYTQYFSDIYFGGKELNP--------------------- :. *** **