MUSCLE (3.8) multiple sequence alignment TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA ------------------------------------------------------------ DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA ------------------------------------------------------------ cnrN_DdisP039_AA ------------------------------------------------------------ DDB_G0285967_DdisP041_AA ------------------------------------------------------------ Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA MAAAGGEEALPVAPADMSDSLRLLEDAIDHYRHRHEACLAQSAGGEADPSAITVNVHPDV pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA ------------------------------------------------------------ DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA ------------------------------------------------------------ cnrN_DdisP039_AA ------------------------------------------------------------ DDB_G0285967_DdisP041_AA ------------------------------------------------------------ Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA QVQLNREDESTVRLANGTVIQHRYACLDRRVSFPTVLLLLSLYRIDCSSRIVNLASTRQS pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA ------------------------------------------------------------ DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA ------------------------------------------------------------ cnrN_DdisP039_AA ------------------------------------------------------------ DDB_G0285967_DdisP041_AA ------------------------------------------------------------ Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA LSHRSLPSSFNGTKIVSLPDGTVVEILLDGTRYIRNARTGTILTETADGAQSVSNPAQTP pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA ----------------------------------------------MVTPPPDVPSTSTR DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA ------------------------------------------------------------ cnrN_DdisP039_AA ------------------------------------------------------------ DDB_G0285967_DdisP041_AA ------------------------------------------------------------ Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA LHKPEKRVGFGSLAPLLEKQQMYASTTNNAEHTGTAQSPALDSTTNASASPSPSPSKGTT pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------MREEGSELEMEKGFLKW------------------------------- DDB_G0275865_DdisP040_AA --MDFLKKLNQDLIKKSNELGEEINKQVN------------------------------- daf-18_CeleP048_AA SMARDLQENPNRQPGEPRVSEPYHNSIVE------------------------------- DDB_G0292920_DdisP043_AA -------------------------MSDG------------------------------- DDB_G0289979_DdisP042_AA --------------------------MYN------------------------------- cnrN_DdisP039_AA --------------------------MNQ------------------------------- DDB_G0285967_DdisP041_AA ------------------------------------------------------------ Pten_DmelP035_AA -----------------------MANTIS------------------------------- PTEN-1_MbreP028_AA ASASAMDRSAVEEPDEDQDASLDEPDSEDDVDSSSDEEEIDRKPSLPDAASAASVVEHDN pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA ------------------------------------------------------------ DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA ------------------------------------------------------------ cnrN_DdisP039_AA ------------------------------------------------------------ DDB_G0285967_DdisP041_AA ------------------------------------------------------------ Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA VIHQGWLFKEGGQIRSWRRRYFVLQSNGLLVYFPDAPQASGRNSTPINAIDVVGAEVTQS pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA ------------------------------------------------------------ DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA ------------------------------------------------------------ cnrN_DdisP039_AA ------------------------------------------------------------ DDB_G0285967_DdisP041_AA ------------------------------------------------------------ Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA TSSKRPHGFIVASDQSAKRRSSATNKREKYVLAGSSDADRDAWMARIRYCAALDSQSLDG pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ---------------------KPVNLMKKILSLPM--KKTKND-IGLRLDISYILVNLIV DDB_G0275865_DdisP040_AA ---------------------STVLKIRTQVSENNTTIRFKDG--EFDLDLSYITERIIA daf-18_CeleP048_AA ---------------------RIRHIFRTAVSSNR--CRTEYQ--NIDLDCAYITDRIIA DDB_G0292920_DdisP043_AA ---------------------SGFDYFRTIVSGRK--KRFIQD--GFNLDLSYITERILA DDB_G0289979_DdisP042_AA ---------------------SIVKAVRKTISADK--NRYENE--EYDLDLTYITERVIA cnrN_DdisP039_AA ---------------------VFFSKIRSLVSADR--HRFKSKEMDLDLDLSYITDNILA DDB_G0285967_DdisP041_AA -----------------------MDLVRKMVSKKK--RRFEMY--NFDLDLSYITDRVIA Pten_DmelP035_AA ---------------------LMSNVIRNVVSKKR--IRYKEK--GYDLDLTYINDNIIA PTEN-1_MbreP028_AA TILPVAQHSLASRFTNFARGINASNKVRQLVSKQK--IRFQKD--GFDLDLTYITPNIVA pten_DdisP044_AA ----------------------MSNLLRVAVSKQK--RRYQKN--GYDLDLAYITDNIVA PTEN-2_MbreP029_AA ----------------------MATIAKHLVSKKK--RRFMDE--GFDLDLTFITRNIVA PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ---------------------MATNKFRHLVSKRK--RRFIAD--GFDLDMTFIKPNIVA PTEN_NvecP038_AA -----------------------MSYFKQLVSKKK--RRFQED--GFDLDLTYIKPNIVA PTEN_HsapP064_AA ----------------------MTAIIKEIVSRNK--RRYQED--GFDLDLTYIYPNIIA PTEN-2_SpurP045_AA -----------------------------MVSKKK--RRFIDK--GFDLDLSYIYPNIIA TEP1_ScerP061_AA CSYPVNTYP--KLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAK DDB_G0275865_DdisP040_AA MSFPSEDTVINSTWYRNSRVDVKKMLDKYH-RDHYLIINL-TEK---------------S daf-18_CeleP048_AA IGYPA-TGI--EANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGY---------------Y DDB_G0292920_DdisP043_AA MGYPA-DSI--HKAFRNDINEVYNFFEKYH-SAHWKILNVAMEI---------------S DDB_G0289979_DdisP042_AA MSFPA-DGV--ESAYRNSIYDVSKLLNTSH-KDHYLIYNL-SER---------------K cnrN_DdisP039_AA MGFPG-TGL--EASWRNSIDDVCELLKQKH-HGKYMIWNL-SER---------------V DDB_G0285967_DdisP041_AA MGFPS-ESL--EGLYRNRMRDVQRFFNTLH-ADHYKVYNLCSER---------------K Pten_DmelP035_AA MGYPAPDKL--EGLFRNRLEDVFKLLEENH-AQHYKIYNLCSER---------------S PTEN-1_MbreP028_AA MGYPA-EGT--EAVYRNRYEDTLRFLEERH-PGAYRVYNLCSER---------------A pten_DdisP044_AA MGFPS-EKV--EGVFRNPMKDVQRFLDQYH-KDHFKVYNLCSER---------------V PTEN-2_MbreP029_AA MGFPA-EGR--EGIYRNHMRDVKRFFDYRC-KDHYRVYNLCSER---------------D PTEN-1_SpurP044_AA MGFPA-ESL--ERMYRNDMEHVVKFLNSHH-QDHYKVYNLCSER---------------N PTEN_AqueP041_AA MGFPS-EKL--EGVYRNKMSDVQRYFDTHY-TDHYKVYNLCSER---------------F PTEN_NvecP038_AA MGFPS-EKL--EGVYRNHMDEVYRFLEQKH-KDSYKVYNLCSER---------------Q PTEN_HsapP064_AA MGFPA-ERL--EGVYRNNIDDVVRFLDSKH-KNHYKIYNLCAER---------------H PTEN-2_SpurP045_AA MGFPA-ESL--EGVYRNKLEVVVKFFNEKH-GERYKVYNLCSER---------------N .:* :** : : *. TEP1_ScerP061_AA FESKDFEIQELRSTLINDGKIPIS-PIDLETRTLVEEETNNVICERIGWLDHFPPPFELL DDB_G0275865_DdisP040_AA YDSSFF-----------GGRVHHI-GCV----------------------DNHSPSLGLL daf-18_CeleP048_AA YDADNF-----------DGNVICF-DMT----------------------DHHPPSLELM DDB_G0292920_DdisP043_AA YSTTKV-----------GGNVIVM-GFE----------------------DHTPPPFLLL DDB_G0289979_DdisP042_AA YDYSLF-----------NGMVLDWCGFP----------------------DHHAPPLGLL cnrN_DdisP039_AA YDYSKL-----------NNQILEF-PFL----------------------DHHPPPLSLL DDB_G0285967_DdisP041_AA YEHCRF-----------EDRVSEY-PFD----------------------DHCPPTLNII Pten_DmelP035_AA YDVAKF-----------RGRVAVY-PFD----------------------DHNPPTIELI PTEN-1_MbreP028_AA YPPSRF-----------HNRVGVY-PFD----------------------DHNPAPLPLV pten_DdisP044_AA YDHSKF-----------YGRVGYY-PFD----------------------DHNAPQFEMI PTEN-2_MbreP029_AA YDPQKF-----------YGRVAKY-PFD----------------------DHNAPPFLLM PTEN-1_SpurP044_AA YDTSRF-----------DHRVAHY-PFD----------------------DHNPPRIELI PTEN_AqueP041_AA YDPKKF-----------H-KVTVY-PFD----------------------DHNPPPFELI PTEN_NvecP038_AA YDPMRF-----------HNRVATY-PFD----------------------DHNAPPFELI PTEN_HsapP064_AA YDTAKF-----------NCRVAQY-PFE----------------------DHNPPQLELI PTEN-2_SpurP045_AA YDTTKF-----------YNRVAHY-PFD----------------------DHNPPRLELI : . : *: .. : :: TEP1_ScerP061_AA EEIVDGIENYLSVSK-NRVAVLHCRMGKGRSGMITVAYLMKYLQCPLG-----------E DDB_G0275865_DdisP040_AA LYAVQVIHKWLSEDP-KNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKE----------E daf-18_CeleP048_AA APFCREAKEWLEADD-KHVIAVHCKAGKGRTGVMICALLIYINFYPSPR----------Q DDB_G0292920_DdisP043_AA LDIIETMNKWLDSDE-QNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLFYSSDTILYN DDB_G0289979_DdisP042_AA FKIVMTIYSWLEKDP-MNVVVVHCMAGKGRTGTVISALLQYGGLFEGAS----------D cnrN_DdisP039_AA FEIVNSLSNWLKADA-ENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMD----------D DDB_G0285967_DdisP041_AA SEFCNDMEMWLDQNP-ENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGS----------E Pten_DmelP035_AA QRFCSDVDMWLKEDS-SNVVAVHCKAGKGRTGTMICAYLVFSGIKKSAD----------E PTEN-1_MbreP028_AA LACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGICPDPD----------S pten_DdisP044_AA DAFCRDVDAWMKEDS-KNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTE----------D PTEN-2_MbreP029_AA QPFCEDVHQYLSEDS-RNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTE----------E PTEN-1_SpurP044_AA RPFCEDVMQWLAEDK-DNVAAIHCKAGKGRTGVMICALLLHQGRCLTAA----------E PTEN_AqueP041_AA QPFCEDVDGWLKEDN-RNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVK----------D PTEN_NvecP038_AA KPFCDDVDEWLKASN-LNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTK----------E PTEN_HsapP064_AA KPFCEDLDQWLSEDD-NHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQ----------E PTEN-2_SpurP045_AA KPFCEDLDNWLGADG-QNVAAIHCKAGKGRTGVMICAYMLHRRLYQTAS----------E :: . .: :** * **:* : . : . TEP1_ScerP061_AA ARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFIT--HEKAAQE---GISNEAVKFKF-- DDB_G0275865_DdisP040_AA ALQLFASQRTTSK--VGVKVPSQLRYIDYVHQLVTSQRPVDVVQNPMKLRLNAIMIKPSP daf-18_CeleP048_AA ILDYYSIIRTKNN--KGVTIPSQRRYIYYYHKLRE--RELNYLP-L-RMQLIGVYVERPP DDB_G0292920_DdisP043_AA TISFFNQMRANNS--ECVTVPSQKRYVGYYIQYLR--DQVTHASLLSPAQFKILNIDVIG DDB_G0289979_DdisP042_AA AMRYFAVKRSNNN--YGITGPSQIRYTQYFSDIYF--GGKELNP-G-PVFLKSISMVTLP cnrN_DdisP039_AA AKNHFAEKRSKMK--KGVTQPSQQRYINYFKEIVS--GSHMVEE-F-VLTFRSIELGPLT DDB_G0285967_DdisP041_AA SMRLFANKRTHNS--KGVTIPSQIRYVRYFEALLQYGKPIPKPPSI-TKVLSMIKMNSLP Pten_DmelP035_AA ALAWYDEKRTKDR--KGVTIPSQRRYVQYFSKLVC--SSVPYSK-V-SLNVCEIRFSESS PTEN-1_MbreP028_AA AMTMFGAKRTHNG--KGVTIPSQRRYIRYFHTMLQ--GDRTVPPAT-PLTLTGIRLHGVP pten_DdisP044_AA SLRFYAALRTYNQ--KGVTIPSQIRYVGYFGRSIR--ESIKYVP-R-NVTLKKIVLRPLP PTEN-2_MbreP029_AA ALEFYGHARTMNG--KGVTIPSQVRYVHYYGRYVR--EQREFEP-I-PLIMKRIILHGIP PTEN-1_SpurP044_AA SMEYYGKIRTTDG--KGVTIPSQRRYVQYYGELVK--RNTLYKT-Q-TVLLKRVQLYTIP PTEN_AqueP041_AA ALQFYGEARTQNA--KGVTIPSQRRYVQYYGHLIR--NNLQYSP-R-TILLHAIRLEGIP PTEN_NvecP038_AA AMEYYGNARTRNA--KGVTIPSQRRYVEYYGYLLR--NCLTYVP-T-MVLLRGFEIITIP PTEN_HsapP064_AA ALDFYGEVRTRDK--KGVTIPSQRRYVYYYSYLLK--NHLDYRP-V-ALLFHKMMFETIP PTEN-2_SpurP045_AA ALDFYASKRTKNR--KGVTIPSQRRYVEYYGNLIV--RELEYKP-T-TLLLTRIDLETVP : * :. *** ** * . . TEP1_ScerP061_AA ----------KFRLA----KMTFLRPSSLITSESAIVT--TKIQHYNDDRNALLTRKVVY DDB_G0275865_DdisP040_AA ----------VVS------GKSGQVWKPTIEI-FNVMKPLEPHLLFSTKDLDGPFNKNQ- daf-18_CeleP048_AA KTWGGGSKI-KVEVG---NGSTILFKPDPLIISKSNHQ--RERATWLNNCDTPNEFDTGE DDB_G0292920_DdisP043_AA ----------LYT------STQTPHFNIEIHLNYNPKI--RNLPIIIRGSNTGIVF---- DDB_G0289979_DdisP042_AA ----------KFFLGPLKQGVCPVLNI------YSATQ--KGVRIFTSAPIEGDTKETRT cnrN_DdisP039_AA KDQANSLSFEIFEHA----KEPILN--------FASSSNSIQIVPINNDNSESNNNNNNN DDB_G0285967_DdisP041_AA ----------NFNIG----GGCEPY--------LSIVQ--QGKSVFYSKPVKLKK----- Pten_DmelP035_AA ---------------------CVQN--------LGMVE--CSISVLHDSATENAKPDRLK PTEN-1_MbreP028_AA ----------NYDFS----GGCQPY--------YQVYQ--EGVLIFSSKPAELRQLQAYK pten_DdisP044_AA KEINLSEV--QFNIS---VGKNCVFNSKEHNMNVVISK--KKKTVVDKNKKDPKKKLTKE PTEN-2_MbreP029_AA ----------DFK-D----GTCVPQ--------FTLRHGPQHVLTFKSGWYEGISR---- PTEN-1_SpurP044_AA ----------MMS-S----GTCCPF--------FTVHQ--HKVKIHTQEAVKGVKK---- PTEN_AqueP041_AA ----------NFS-G----GTCAPF--------FIVRK--HKVVLYTSKVYESIRR---- PTEN_NvecP038_AA ----------NMQ-G----GNCCPF--------YIIWQ--YKVKIHTSKLIESSKK---- PTEN_HsapP064_AA ----------MFS-G----GTCNPQ--------FVVCQ--LKVKIYSSNSGPTRR----- PTEN-2_SpurP045_AA ----------MFN-G----GSCAPA--------FVIYQ--QKVKIFSSQPYEVAKKE--- TEP1_ScerP061_AA SDIMAHE----------------------------------------------------- DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA QKYHGFVS---------------------------------------------------- DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA Y----------------------------------------------------------- cnrN_DdisP039_AA NNNNNNNNNQ-------------------------------------------------- DDB_G0285967_DdisP041_AA ------------------------------------------------------------ Pten_DmelP035_AA TLPIDF------------------------------------------------------ PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA NSEKNIDSQQQQQSQSSLSQSQQGQSSPNMQSLSASGTISSGSNVGTVNGNTLHQLGGSQ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA -------------CGGNMT-----FIFGRDYLTLENDCRIEFTLG--TSKSKAASSIISW DDB_G0275865_DdisP040_AA -------------NDAFCKVQGDVVIIETQSLVLQGDVLVKIYHGFSDILSKEVLNVIMD daf-18_CeleP048_AA -------------KRAYCF-----MVPEDAPVFVEGDVRIDIREI-------GFLKKFSD DDB_G0292920_DdisP043_AA -------------YQDFYS-----YILREKGIIAKGDTLIKF------------NSLDSP DDB_G0289979_DdisP042_AA -------------QSGNAT-----IVFEV-RKIVRGDILLVFSHI---------TPFYRV cnrN_DdisP039_AA -------------QQQLYK-----IIILI-QKKVQNDVLIRVYRG-----DTGKGKGKMK DDB_G0285967_DdisP041_AA -------------GTIHQQ-----VELDCGNILLVNDVQIQFFNR------------NSK Pten_DmelP035_AA -------------QKSFV------LTIKP-SIPVSGDVKFELTKK-------------SP PTEN-1_MbreP028_AA -------------RQTHRD-----IRFSC-NMAIEGNIRIELWDC--------DRGFHSE pten_DdisP044_AA FSLSDLADGNTIGNDEYIS-----FEIG--ALSLAGDIRIEFTNK-----Q--------D PTEN-2_MbreP029_AA -------------EQGTAT-----LELKP-HTPVCGDVKLEFIHR---------KGSSGK PTEN-1_SpurP044_AA -------------GLSCVE-----FELPH-ALPIRDDVKIEFYHK---------SGLLKM PTEN_AqueP041_AA -------------TDAFAE-----LMLTK-PIPLCDDIKVEFYHN-----PRFGSKASYT PTEN_NvecP038_AA -------------GDTSIK-----LELSQ-PLPICGDIKVEFFHK---------DTFGRK PTEN_HsapP064_AA -------------EDKFMY-----FEFPQ-PLPVCGDIKVEFFHK--------QNKMLKK PTEN-2_SpurP045_AA -------------RSVRCE-----FPL---PVPICGDIKIEFFNK---------PNKLKK .: . . TEP1_ScerP061_AA TS--CASCWLNIYLETLMHII--------------------------------------- DDB_G0275865_DdisP040_AA KP--SLRLAFHTSFIDNHCLD--------------------------------------- daf-18_CeleP048_AA GK--IGHVWFNTMFACDGGLNGGHFEYVDKTQPYIGDDTSIGRKNGMRRNETPMRKIDPE DDB_G0292920_DdisP043_AA QC--VFRFLFHTSFLLTPTTQ--------------------------------------- DDB_G0289979_DdisP042_AA EQ--ICRANFHTGMFSFPTLILTKSDLDGADGDKRFSSDFHLRLDFQEVVNQNQQQQQQL cnrN_DdisP039_AA KQ--IFHLIFNIAFVNLDQCLFGMNEFDHF------------------------------ DDB_G0285967_DdisP041_AA GH--MFSYCFHTAFIEGTKIHIRRQEIDKAHKDLKHFHSNFSIELIFLEDDRDDDSSSVS Pten_DmelP035_AA DK-IICHFWLNTFFVRNYSPC--------------------------------------- PTEN-1_MbreP028_AA EK--MFAATFFTGMVEGTSLR--------------------------------------- pten_DdisP044_AA DR--MFMFWVNTSFVQQLEI---------------------------------------- PTEN-2_MbreP029_AA EK--MFHLWFNTFFIVNNRFY--------------------------------------- PTEN-1_SpurP044_AA DKRLMFHMWFNTYFIVHPIQP--------------------------------------- PTEN_AqueP041_AA EK--MFLFWFNTFFVDWHVMQ--------------------------------------- PTEN_NvecP038_AA ER--MFQFWFNTFFISTGANM--------------------------------------- PTEN_HsapP064_AA DK--MFHFWVNTFFIPGPE----------------------------------------- PTEN-2_SpurP045_AA DR--MFHFWFNTFFVANSNLL--------------------------------------- . : TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA TGNEFESPWQIVNPPGLEKHITEEQAMENYTNYGMIPPRYTISKILHEKHEKGIVKDDYN DDB_G0292920_DdisP043_AA ------------------------DSQSIITLY--------------------------- DDB_G0289979_DdisP042_AA LNSNNGDLTPYIIPANAQTSIEYQKEIKKEIKWIRHEAIAKKDHRNGSIFFLPSNNSEKI cnrN_DdisP039_AA ------------------------KSSKKYDPNLQMECRFQNNCTGAP------------ DDB_G0285967_DdisP041_AA EESVEEKRVFNTSYATGLAKLYHNSNSNNKSLTSSTSSTSNLSSSTNNTFEIISNNNNNN Pten_DmelP035_AA ------------------------ESDGTVNKYIHT------------------------ PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------DKDYFGQARSHSRPTSTVSCPSPDQARAPFAEDEML PTEN_AqueP041_AA ------------------------QEAQNAMATNSLSVSWLYTA---------------- PTEN_NvecP038_AA ------------------------TDSREGEPTIHTFKESR------------------- PTEN_HsapP064_AA ------------------------ETSEKVENGSLCDQEIDSICSIERADN--------- PTEN-2_SpurP045_AA ------------------------NSSSQQDLANNGSSDNSSHCSEDNMEAL-------- TEP1_ScerP061_AA -------------------------------------------------KDDSS------ DDB_G0275865_DdisP040_AA ---------------------------------------LNRSTLDEKDNCIQS------ daf-18_CeleP048_AA DRKLPMGDKSYTESGKSGDIRGVGGPFEIPYKAEEHVLTFPVYEMDRALKSKDLNNGMKL DDB_G0292920_DdisP043_AA ---------------------------------------FQKDNLDGGSGGAFLD----- DDB_G0289979_DdisP042_AA KQAKDTASKQGTFGVHSGYLFKKGHNFK---SWRRRWFVLKDNILSYYKSPKDTAPAGII cnrN_DdisP039_AA -------------------------------DHSFKIWNIMALQYQRTKSSLNNSITDIK DDB_G0285967_DdisP041_AA NN-----------------------------NNNNNNINSNNNKINDENSNKNNNNNNII Pten_DmelP035_AA ---------------------------------------LSKSEIDDVHKDSEH------ PTEN-1_MbreP028_AA ---------------------------------------MVRQELDGAHKKKHL------ pten_DdisP044_AA ---------------------------------------IPKSGLDKAHKDKNH------ PTEN-2_MbreP029_AA ---------------------------------------AAQSEVDKANKDKKN------ PTEN-1_SpurP044_AA NG-----------------------------GEEF-VLELHKDEIDKANKDKTN------ PTEN_AqueP041_AA --------------------------------SHFRVVILPKNEIDKANKDKKH------ PTEN_NvecP038_AA -------------------------------NSDVRWFAIPKQFVDKAHKDNKC------ PTEN_HsapP064_AA -------------------------------DKEYLVLTLTKNDLDKANKDKAN------ PTEN-2_SpurP045_AA -------------------------------DADCTVLRLQKDQLDRANKDKTN------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA HVVLRCVDTRDSKMMEKSEVFGNLAFHNESTRRLQALTQMNPKWRPEP------------ DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA PINEIVNIEIECEISQAEGYDYCFQISTSKANYLISAENERDLEDWTE------------ cnrN_DdisP039_AA SINEINSTNNNNILASSAPTPLTTTTTTTTTTTTTSLPSS-------------------- DDB_G0285967_DdisP041_AA NNNSFSAWGNNSKIVKNRGSKLAFICPKCNLPITATDPSINRNSENYHWKCVVCVKCSKP Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA -----------------------------------------------------CAFGSKG DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA -----------------------------------------------------ILRSAKR cnrN_DdisP039_AA ------------------------------------------------------------ DDB_G0285967_DdisP041_AA LGGESDCVFENNEMLCTDCGTEFFKSCSGCNLVIKTSDFEELGDHIYHRSCFLCYYCTSY Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA -----------------PDYFQVE------------------------------------ DDB_G0275865_DdisP040_AA --------------DKFSQDFSLR------------------------------------ daf-18_CeleP048_AA AE------------MHYPPSVRYS---SNDGKYNGACSENLVSDFFEHRNIAVLNR---- DDB_G0292920_DdisP043_AA --------------SKYKTDFAIR------------------------------------ DDB_G0289979_DdisP042_AA MVQSTGRLFIEILEVKYQPNMILADRSFINNPQPNGVLPLPIKMLDINDHPIDIIT---- cnrN_DdisP039_AA --------------EHSTPQILIS-----------------------SSDANLDLK---- DDB_G0285967_DdisP041_AA LGGKDFIVENINNIRRFKCSSCIDNKNRQNGDDDDNNNNDNIENILENKIPEICDKLDKE Pten_DmelP035_AA --------------KRFSEEFKIS------------------------------------ PTEN-1_MbreP028_AA --------------KMFEPQFAME------------------------------------ pten_DdisP044_AA --------------KAFPEDFHVE------------------------------------ PTEN-2_MbreP029_AA --------------KIYPEGFAIE------------------------------------ PTEN-1_SpurP044_AA --------------KVFSPNLKVK------------------------------------ PTEN_AqueP041_AA --------------KQYPCNFKVH------------------------------------ PTEN_NvecP038_AA --------------KVFSPDFKVS------------------------------------ PTEN_HsapP064_AA --------------RYFSPNFKVK------------------------------------ PTEN-2_SpurP045_AA --------------KWYSPNFKVI------------------------------------ TEP1_ScerP061_AA ----------------------RLKRDEMLGTTISWQ----------------------- DDB_G0275865_DdisP040_AA -----------------------LLFSPYQEQQQQPQ----------------------- daf-18_CeleP048_AA --------------------YCRYFYKQRSTSRSRYP----------------------- DDB_G0292920_DdisP043_AA -----------------------VLLEPILSNNISNN----------------------- DDB_G0289979_DdisP042_AA --------------------YVTVHLGKKRDTTSHKS-----VLYNPVFMYAGDFPIYDD cnrN_DdisP039_AA --------------------NCNINCDSSSGGGSNSS----------------------- DDB_G0285967_DdisP041_AA IIKLVIEIDKSTEPSPVSSIDPSMIFNDLEDNGKRRQMTVESMICSKCELAINQSRPIIL Pten_DmelP035_AA -----------------------IVFEAENFSNDVQA----------------------- PTEN-1_MbreP028_AA -----------------------LTFKS-------------------------------- pten_DdisP044_AA -----------------------LTFDQLDQQQSHTT----------------------- PTEN-2_MbreP029_AA -----------------------ILFDNPEGNAKTSS----------------------- PTEN-1_SpurP044_AA -----------------------LFFARGREDQVPPT----------------------- PTEN_AqueP041_AA -----------------------MVLSEADNPGFSLD----------------------- PTEN_NvecP038_AA -----------------------NVF---------------------------------- PTEN_HsapP064_AA -----------------------LYFTKTVEEPSNPE----------------------- PTEN-2_SpurP045_AA -----------------------CYFKRVENEKPRRP----------------------- TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ------------------------------------------------------------ daf-18_CeleP048_AA --------------------------RKFRYCPLIKKHFYIPADTDDVDENGQPFFHSPE DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA EPSDLVVSLWVRSSVQNIKDTLAAEFILKHNQLTNKYNTDWRDFNRIKSNLLSKMSLKIG cnrN_DdisP039_AA ------------------------------------------------------------ DDB_G0285967_DdisP041_AA DCGIYHRECFQCSECFDETPMDPSLYYIRNDKPVCFDCDVNHIMNEAHSEITCYGCKLPI Pten_DmelP035_AA ------------------------------------------------------------ PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA -----------------------------PLQPLQPQQYQPANYQLPQQFQQPQQQQQ-- daf-18_CeleP048_AA HYIKEQEKIDAEKAAKGIENTGPSTSGSSAPGTIKKTEASQSDKVKPATEDELPPARL-- DDB_G0292920_DdisP043_AA -------------------------NNYNNNNNNNNNSIENNNGVVLRKAPLPPVISN-- DDB_G0289979_DdisP042_AA MAYGSEVDIQLSEIAKGSSQQQQQQSSSSLSASPSSSPHTSTNYLNNKPHVSFNHSIY-- cnrN_DdisP039_AA ----RNSNSNSRGGSSNSSSNRSSTSSRSSITTDSIKPSCSSDSICNNSSICNNSCNN-- DDB_G0285967_DdisP041_AA VDEVMMDALNFKWHVACLVCSKCAIQIEGQLGDHQGLIYCKDHFEELVGTKCDQCNQYID Pten_DmelP035_AA --------------EASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVNDNTTKS-- PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA --------------VVASAEEQTNNQHYPQSSNNVATSSSHHDNITVVASDAP------- PTEN-2_MbreP029_AA ----------------------------PLAANSLSASTASAQGMVPTASDGSDPAIP-- PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA --------------------------------------------------------PQHF daf-18_CeleP048_AA ---------------------------------------------------------PDN DDB_G0292920_DdisP043_AA ---------------------------------------------------------NTN DDB_G0289979_DdisP042_AA ---------------------------------------------------------NNS cnrN_DdisP039_AA ---------------------------------------------------------NNN DDB_G0285967_DdisP041_AA GMFLKVNGKNLCPTCFRCFCCNEVLEGGKYFEKNGESICEKCRNEDILKRKTQIHIQHTL Pten_DmelP035_AA ---------------------------------------------------------QTI PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA ---------------------------------------------------------QNN PTEN-2_MbreP029_AA ---------------------------------------------------------ATS PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA -------------------------ELDGFGELSTHGLKLFQA----------------- DDB_G0275865_DdisP040_AA QQSQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQYQP----------------- daf-18_CeleP048_AA VRRFPVVGVDFENPEEESCEHKTVESIAGFEPLEHLFHESYHPNTAGNMLRQDYHTDSEV DDB_G0292920_DdisP043_AA FFDNNNNNNNSFNNSNNNNFNININNCNGNSIQPHVQQAPPPP----------------- DDB_G0289979_DdisP042_AA NILSANSNSISLSNSLNFNTTPSSSTTTTTTTATNSNVSTSLPQPSTIYLAKSREENKIN cnrN_DdisP039_AA NNNNNNNNNNNNNNNNNNNNNNKNSNNNNNESSSNSNDDSDSE----------------- DDB_G0285967_DdisP041_AA ITSLKNSQQISEKSSSSLSTSSTTTTTTTNNVVSSTSSTSTSP----------------- Pten_DmelP035_AA ETLDHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLND----------------- PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA NNNNNLNSSNSNNATTTTTKNNISLASSQSNPVQQESNPSTTT----------------- PTEN-2_MbreP029_AA RGGQPMLPSRGPDASGEPLSAIPGKLTHRDSNVSQAPEFSDSD----------------- PTEN-1_SpurP044_AA ---------------PEPSEGNLSPSQSENDLLDDQDLDDGTD----------------- PTEN_AqueP041_AA ----------------HYCEEDLESQTDEQPDDPHHGEENLSD----------------- PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ----------------ASSSTSVTPDVSDNEPDHYRYSDTTDS----------------- PTEN-2_SpurP045_AA ----------------SGDSNDRSSGTSSDHEHSDGGDISETD----------------- TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA ---------------------------------------------------------PQQ daf-18_CeleP048_AA KIAEQEAKAFVDQLLNGQGVLQEFMKQFKVPSDNSFADYVTGQAEVFKAQIALLEQSEDF DDB_G0292920_DdisP043_AA ------------------------------------------------------------ DDB_G0289979_DdisP042_AA NLNSSNNSNTSVNSNLSRDPLTGLPTVNNNNGKQNESNKFGYNPYDEDDEDKLIEALQSQ cnrN_DdisP039_AA ------------------------------------------ASIRKRKNTLWSSGSSIK DDB_G0285967_DdisP041_AA --STSPSNSPLSSSIQKDAPLFCLNKSRSLFRNSIKIHLEDLKNSGERKTLLYPSFHRQM Pten_DmelP035_AA ---------------------------------------STKEEIKRNHIFNQPSIKKTD PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA ------------------------------------------------------------ PTEN-2_MbreP029_AA ------------------------------------------------------------ PTEN-1_SpurP044_AA ------------------------------------------------------------ PTEN_AqueP041_AA ------------------------------------------------------------ PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA ------------------------------------------------------------ PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ------------------------------------------------------------ DDB_G0275865_DdisP040_AA SQPQHFQQQPPPQYQPPQQYQPPQQYQQPQPYQPQPQQYQQQQPP--------------- daf-18_CeleP048_AA QRVQANAEEVDLEHTLGEAFERFGHVVEESNGSSKNPKALKTREQMVKETGKDTQKTRNH DDB_G0292920_DdisP043_AA ----------------------------------------VPCRS--------------- DDB_G0289979_DdisP042_AA LNDTEDDEDL-LLSTLKNKLDDFDDEDGGDDYNNNNSTTRVLEDD--------------- cnrN_DdisP039_AA LKPSPNLSRLSLFNGHRQSFTKKINPNNNEENVDQKTLPILKKET--------------- DDB_G0285967_DdisP041_AA RKQTFKTAYPSLRGTRRKDFLNHSKNELDSSNNSLSTLVNAFVPP--------------- Pten_DmelP035_AA LIKWQNSEVHITSDTRSINENKNINYNSYITCKQSSPKFNCGTED--------------- PTEN-1_MbreP028_AA ------------------------------------------------------------ pten_DdisP044_AA ---------------------------QVSEENSAPKVEAEKIEN--------------- PTEN-2_MbreP029_AA ---------------------------------------LTTTDE--------------- PTEN-1_SpurP044_AA ------------------------------------------SGD--------------- PTEN_AqueP041_AA -----------------------------------------TDPE--------------- PTEN_NvecP038_AA ------------------------------------------------------------ PTEN_HsapP064_AA -------------------------------------------DP--------------- PTEN-2_SpurP045_AA ------------------------------------------------------------ TEP1_ScerP061_AA ----------------------------------LKLEWEII-------- DDB_G0275865_DdisP040_AA ----------------------------------QQQSPNLQKQNNQYNM daf-18_CeleP048_AA VLLHLEANHRVQIERRETCPELHPEDKIPRIAHFSENSFSDSNFDQAIYL DDB_G0292920_DdisP043_AA ----------------------------------KKPIYS----YEPYEL DDB_G0289979_DdisP042_AA ----------------------------------NISEFEEIRDSQNSN- cnrN_DdisP039_AA ----------------------------------NDPSESDIKNVEIIQD DDB_G0285967_DdisP041_AA ----------------------------------QQSNNSNTTTTTNTST Pten_DmelP035_AA ----------------------------------GEEDWE---SGESTYL PTEN-1_MbreP028_AA -------------------------------------------------- pten_DdisP044_AA ----------------------------------SNASANDSETSSNSSS PTEN-2_MbreP029_AA ----------------------------------DDDEWEGLPISDV--- PTEN-1_SpurP044_AA ----------------------------------EDCIYE---TSESSVV PTEN_AqueP041_AA ----------------------------------DDENWE---EVESVAV PTEN_NvecP038_AA -------------------------------------------------- PTEN_HsapP064_AA ----------------------------------ENEPFDEDQHTQITKV PTEN-2_SpurP045_AA ----------------------------------SESEWD---VTEITHV