MUSCLE (3.8) multiple sequence alignment Y41D4A.5_CeleP217_AA MSDDTSASVWNDGGPPEIQEQKPKSPPPPLPTSNPVVKDTPNVVPTGDLIQFESEEERAA PTPN18_HsapP073_AA ------------------------------------------------------------ PTPN12_MbreP064_AA ------------------------------------------------------------ PTPN12_HsapP072_AA ------------------------------------------------------------ PTPN22_HsapP074_AA ------------------------------------------------------------ PTPN12_SpurP056_AA ------------------------------------------------------------ PTPN12_AqueP049_AA ------------------------------------------------------------ PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA TTVPNGNPVIFEKNPAMDGLLREFLKEEEAYTPQD--------YLRRFYQIRVEQEKLRM PTPN18_HsapP073_AA -------------MSRSLDSARSFLERLEARGGREGAV-----LAGEFSDIQACSAAWKA PTPN12_MbreP064_AA -----------MRKSDQQDALEG--------------------FGAEFQRLRDMTAAYKA PTPN12_HsapP072_AA --------------MEQVEILRKFIQRVQAMKSPDHNGEDN--FARDFMRLRRLSTKYRT PTPN22_HsapP074_AA --------------MDQREILQKFLDEAQSKKITKEE------FANEFLKLKRQSTKYKA PTPN12_SpurP056_AA --------------MSLKENLENFLEHYENMADLSSSLDGSDSFELEFNHLKQISQRYRT PTPN12_AqueP049_AA ---------MAELDSDFTLKLNEFLDHFMSLAEDNEENDAT--FNKEFQALKMESQRYKD PTPN12_NvecP072_AA --------------------MQRFLQHKSSLEPRNNPQGENG-FAKEFQELKNISSRQKR * :. . Y41D4A.5_CeleP217_AA EAEYRSECAVAPQHYARNRYRDILPYDKNRVEI-----QKDSENPEGYMNASLIQLPGGK PTPN18_HsapP073_AA DGVCSTVAGSRPENVRKNRYKDVLPYDQTRVIL----SLLQEEGHSDYINGNFIRGVDGS PTPN12_MbreP064_AA ST--SREEGTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDISGSDYINASSVEHGESQ PTPN12_HsapP072_AA EKIYPTATGEKEENVKKNRYKDILPFDHSRVKL----TLKTPSQDSDYINANFIKGVYGP PTPN22_HsapP074_AA DKTYPTTVAEKPKNIKKNRYKDILPYDYSRVEL----SLITSDEDSSYINANFIKGVYGP PTPN12_SpurP056_AA EKVYPTSAGESDVNMRKNRYKDILPFDHSRYLL----SQIDNVEGSDYVNANFLKGAAND PTPN12_AqueP049_AA QNTFPAESGQNPVNKKKNRFKDILPFEYTRVQL----HKIEGVEGSDYINANYIQGPDGN PTPN12_NvecP072_AA DKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVL----PEIKGVDGSDYINGNYIKGPTKN . . .**:.*::*:: .* : ..*:*.. : Y41D4A.5_CeleP217_AA TEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDY PTPN18_HsapP073_AA LAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-EQEPLQTGLF PTPN12_MbreP064_AA CRFIASQGPLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEF PTPN12_HsapP072_AA KAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPF PTPN22_HsapP074_AA KAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPF PTPN12_SpurP056_AA HTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-EGEEHCFGDI PTPN12_AqueP049_AA VEYIAAQGPLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQ-VGESAMYGAI PTPN12_NvecP072_AA IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGM ::*:*.**. *: ::*.:: :::: * * . .* ** Y41D4A.5_CeleP217_AA EITLEEEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLM PTPN18_HsapP073_AA CITLIKEKWLNED-IMLRTLKVTFQ--KESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEA PTPN12_MbreP064_AA EVDNMAEDAIDQD-FLVRTLKVTHK--GASRIIYQYHYHAWPDHGVPARPGSVMRLIAAF PTPN12_HsapP072_AA KISCEDEQART-D-YFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSSFDSILDMISLM PTPN22_HsapP074_AA SVSCEAEKRKS-D-YIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWDV PTPN12_SpurP056_AA LVTQIGQQRVTKD-FMIRTLKATRD--KEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLV PTPN12_AqueP049_AA QVTTDHEENVSND-FIIRQLTAECQ--GEKQVIRQFHYTAWPDHGRPESATPIIRMIEMF PTPN12_NvecP072_AA KISLESEEAMGDG-FTVRTLAVQAG--KTKHNVTQFHYTAWPDHDVPRSATPLIELTRSF : :. . :* * . . * :* ***.. * :: : Y41D4A.5_CeleP217_AA ENIHEEVSPQDSSPILVHCSAGVGRT-----GTIIAINFIREQMKA-ETLHS-IDIFGLV PTPN18_HsapP073_AA RRLQ-G---SGPEPLCVHCSAGCGRT-----GVLCTVDYVRQLLLT-QMIPPDFSLFDVV PTPN12_MbreP064_AA RERQPS---DQAAPLVIHCSAGVGRTGHFLLGTICAIDIVWSMLKQMGLDAPCFDIFQVV PTPN12_HsapP072_AA RKYQ-E---HEDVPICIHCSAGCGRT-----GAICAIDYTWNLLKA-GKIPEEFNVFNLI PTPN22_HsapP074_AA RCYQ-E---DDSVPICIHCSAGCGRT-----GVICAIDYTWMLLKD-GIIPENFSVFSLI PTPN12_SpurP056_AA REYQ-T---AEEPPIVVHCSAGCGRT-----GTICVIDYVRNALQL-EKIDQNFSLYDII PTPN12_AqueP049_AA REHR-K---RHDIPFAIHCSAGCGRT-----GTIIAIDFARTMLIK-KTIPDKLDVFSIV PTPN12_NvecP072_AA RTFV-G---SQDTPVLVHCSAGCGRT-----GTICALDYARTLLQT-GRTEE-LSVFDIV *. :***** *** *.: .:: . : :.:: :: Y41D4A.5_CeleP217_AA MTLRKQRASMVQTQDQFQFVHRCIASYCRRHLG--------------------------- PTPN18_HsapP073_AA LKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQ--------------------------- PTPN12_MbreP064_AA WFLRQHRPAMVQTEDQYVFVYKAILDLVQQVLA--------------------------- PTPN12_HsapP072_AA QEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIE PTPN22_HsapP074_AA REMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHCIPEKNHTLQAD PTPN12_SpurP056_AA VDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLG--------IKPEDYGHNYENVQLKHEH PTPN12_AqueP049_AA QQMRKQRPAMVQALDQYVFVYMAIVELVQQSLT--------------------NV----- PTPN12_NvecP072_AA ANLRRQRVAMVQTKEQYTLVYKAVEELVNEELR--------------------------- :* :* : **: :*: ::: : . : Y41D4A.5_CeleP217_AA ------------------------------------------------------------ PTPN18_HsapP073_AA ------------------------------------------------------------ PTPN12_MbreP064_AA ------------------------------------------------------------ PTPN12_HsapP072_AA PEKQDSP------PPKPPRTRSCLVEGDAKE------EILQPPEPHPVPPILTPSPPSAF PTPN22_HsapP074_AA SYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSEISAKEELVLHPAKSSTSFDFL- PTPN12_SpurP056_AA FEQPRMP------PKVPGQSGAAADKRDSSSHNYVNCNVTPKGVSVDSPELPMPKLPSGP PTPN12_AqueP049_AA ---PQLP------PRMLNFEKA-------------------------------------- PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------IIEEPKLDL--------APPVATADLPVGS PTPN18_HsapP073_AA -----------------------------------NASPHYQNIKENCAPLYDDALFLRT PTPN12_MbreP064_AA --------------------------------SMDNSAL----LPKSTAPVAMESVYDSV PTPN12_HsapP072_AA PTVTTVWQDNDR------------------YHPKPVLHM----VSSEQHSADLNRNYSKS PTPN22_HsapP074_AA ELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSK PTPN12_SpurP056_AA PKSSRGSDSPDGSI----------------YANCDVGAT----SGDSGKPSKDASHPSSS PTPN12_AqueP049_AA PVESPVPTNTDDAV----------------YQNITSLNN--EGSSESDHPVPMARTFSGS PTPN12_NvecP072_AA -----------------------------------KQNHLYVNVSVGDQQGGEEQNYENS Y41D4A.5_CeleP217_AA SGSVRLIAPPTP-------------------------TTGPSTDQTATIANYNQLHHHQS PTPN18_HsapP073_AA PQALLAIPRPPG--------------------GVLRSISVPGSPGHAMADTYAVVQKRGA PTPN12_MbreP064_AA TPAPEAIVKIAE-----------------------PVYINPAMVQACTSSVPKERLRRLS PTPN12_HsapP072_AA TELPGKNESTIE----QID--------KKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGH PTPN22_HsapP074_AA VPITRTKSTPFELIQQRET--------KEVDSKENFSYLESQPHDSCFVEMQAQKVMHVS PTPN12_SpurP056_AA KQTSQAKPRPSPDDRFKSNFKATLSAFKDIEFDVGGTQTTPSSPTPTSVVLTKPKPGQAV PTPN12_AqueP049_AA TTSGSDGNRPHP----------------------------PPKPTKPKPEIPKKPLSEQT PTPN12_NvecP072_AA TSSASSEDQDLP----------------------------PPV----------------- Y41D4A.5_CeleP217_AA ------------------------------------------------------------ PTPN18_HsapP073_AA PAGAGSGTQTGTGTGTGARS---------------------------------------- PTPN12_MbreP064_AA MIRV-------------------------------------------------------- PTPN12_HsapP072_AA AIKIKSASPCIADKISKPQELSSDLNVG----------DTSQNSCVDCSVTQSNKVSVTP PTPN22_HsapP074_AA SAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDL PTPN12_SpurP056_AA KPGAHAKPHIAGKPKTKPSPPVKP--------------SSVDVNAKPVSEKTGNGEFFKA PTPN12_AqueP049_AA SGGLKKPPPMIPRKGSKPEELSHP--------------VPAPRKPSPVP-PTDDPQVPQA PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ PTPN18_HsapP073_AA ------------------------------------------------------------ PTPN12_MbreP064_AA ------------------------------------------------------------ PTPN12_HsapP072_AA PEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTP PTPN22_HsapP074_AA PEKQDGTVFPSSL--LPTSSTSLFSYYNSHDSLSLNSPT----NISSLLNQESAVLATAP PTPN12_SpurP056_AA IATRQNSNPATRS--TPAKDVSHSAAKNTDKKEALRLPIKPTRNLEKSKSEGDRGMVSPG PTPN12_AqueP049_AA PTALPRTSTPSKP--LHSTPSSVSSVSNTPDKSVSKSSILETLINEVGLQPDDLVEVS-- PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ PTPN18_HsapP073_AA --------------------AEEAPLYSKVTPRAQRPGAHAEDARGTL------------ PTPN12_MbreP064_AA --------------------------PQWRDKPLPQAGAKTDADEDDD------------ PTPN12_HsapP072_AA SPTTQVETPD--------LVDHDNTSPLFRTPLSFTNPLHSDDSDSDE-RNSDGAVTQNK PTPN22_HsapP074_AA RIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDD PTPN12_SpurP056_AA VRQGPIKPGF-----NKGISKDRPSQPPPKPPASAKPPLQRANGEDRT--SVKGRHDYEE PTPN12_AqueP049_AA --RDESKPGG-----DYTYASLGATDVPPAIPERTSEALEVMNVPPPL---------YES PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ PTPN18_HsapP073_AA ------------------------------------------------------------ PTPN12_MbreP064_AA ------------------------------------------------------------ PTPN12_HsapP072_AA TNISTASATVSAATSTESISTRKVLPMS----------------------IARHNIAGTT PTPN22_HsapP074_AA SVILRPSKSVKLRSPKSELHQDRSSPPPPL------------------------------ PTPN12_SpurP056_AA VHISPPHDKVKDTTELPSSKNFRGSPTQQMDSFDAKDSGIIRRKTESLRKLSSGSVQSSG PTPN12_AqueP049_AA AELPPPLPPVP------------------------------------------------- PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------SSNHMDEDTSTEEAASVPD----------------------- PTPN18_HsapP073_AA ------------------PGRVPADQSPAGSGAYEDVAGGA------------------- PTPN12_MbreP064_AA ------------------AQCNKDEAMENKHGNDGVDNSWP------------------- PTPN12_HsapP072_AA HSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWS--------ELQSQERSEQK PTPN22_HsapP074_AA ------------------PERTLESFFLADEDCMQAQ-SIETYSTSYPDTMENSTSSKQT PTPN12_SpurP056_AA SDSRSSRKNSDEYAYVQQPTSNIDKLLKSEEGAASPKAASAMYSEAYSEVSSSPNKSGQR PTPN12_AqueP049_AA ----------------MNRTSSPSSLLPSSHHHISPTSSSTAFSVATMRNTDLTNKPKKE PTPN12_NvecP072_AA ------------------PAKTAGAFLVAGTTVTTQ------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ PTPN18_HsapP073_AA --------------------------------------------QTGGL----------- PTPN12_MbreP064_AA ------------------------------------------------------------ PTPN12_HsapP072_AA KSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDI----------- PTPN22_HsapP074_AA LKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESV-QSNNSSSFLNF----------- PTPN12_SpurP056_AA MSASSKEYSYVDTSKIVAPEKPKRGESVSGGNGDAAYDLVGIPSHDGTFDSFMDTDSTYS PTPN12_AqueP049_AA RFSDDTSIPSSSKSSSVSPRKAPRSNIAESANNKYSF--------SGNY----------- PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ PTPN18_HsapP073_AA ------------------------------------------------------------ PTPN12_MbreP064_AA ------------------------------------------------------------ PTPN12_HsapP072_AA ------------------------------------------------------------ PTPN22_HsapP074_AA ------------------------------------------------------------ PTPN12_SpurP056_AA ATGESLDDMGSDIPVLPARTAQSYQLVDDEEKDKDEKASGGGKRNKIKARLANSRDIIGE PTPN12_AqueP049_AA ------------------------------------------------------------ PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ PTPN18_HsapP073_AA ------------------------------------------------------------ PTPN12_MbreP064_AA ------------------------------------------------------------ PTPN12_HsapP072_AA ------------------------------------------------------------ PTPN22_HsapP074_AA ------------------------------------------------------------ PTPN12_SpurP056_AA KQGKIVNNTKGLFKRIGVALKPETSHMAPCPEPDTAKPSNINDLLEKTLLDYKPAYKEGP PTPN12_AqueP049_AA ------------------------------------------------------------ PTPN12_NvecP072_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ---------FPEEPPAPMGPEDLGSSAAF-------- PTPN18_HsapP073_AA --------GFNLRIGRPKGPRDPPAEWTRVSLDL--- PTPN12_MbreP064_AA ----------PKRVKGPTGPRKVPSTWGLAIKMNYER PTPN12_HsapP072_AA --------GFGNRCGKPKGPRDPPSEWT--------- PTPN22_HsapP074_AA --------GFANRFSKPKGPRNPPPTWNI-------- PTPN12_SpurP056_AA VSYKDQEIGFPKRVANPRRPRSPPSSWGVRSAQVHL- PTPN12_AqueP049_AA --------GFGVRVGKPKGPRPPPQQWTAVNGIIH-- PTPN12_NvecP072_AA -------------------------------------