MUSCLE (3.8) multiple sequence alignment Pez_DmelP041_AA MPLKF---LKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLI PTPN14_AqueP050_AA MPRLF----RKSQRYNV-AKNSWVSKIVLL--DNTSIEINLQPDVTGADCLERVAQCMDI PTPN14_SpurP058_AA --MPFGLRLKKTRRYNVSGKNSFVARIQLL--DSAVLEITLTPESLGQDCLDTIAQKLQL PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA --MPFGLKLRRTRRYNVLSKNCFVTRIRLL--DSNVIECTLSVESTGQECLEAVAQRLEL PTPN21_HsapP077_AA MPLPFGLKLKRTRRYTVSSKSCLVARIQLL--NNEFVEFTLSVESTGQESLEAVAQRLEL Pez_DmelP041_AA QQPEFFGLRYLVKGKDKEDEFKWIDLERSLSRQLEKY------AAGPKIYLRVRHYVTTG PTPN14_AqueP050_AA FEIDYFGLQYQ----CKDGYDRWVDREKSLRKQLDKHHVGGAGARNAELRFLVQYYVTN- PTPN14_SpurP058_AA EENIYFGLQYS----NKNYKLRWVDLEKPLKKQLDKN------AHDSMLRLGVMLYTTN- PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA RETHYFGLWFL----SKSQQARWVELEKPLKKHLDKF------ANEPLLFFGVMFYVPN- PTPN21_HsapP077_AA REVTYFSLWYY----NKQNQRRWVDLEKPLKKQLDKY------ALEPTVYFGVVFYVPS- Pez_DmelP041_AA VRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCRQAEYDSYQG-DKQSKDYLK PTPN14_AqueP050_AA ISKLEYEVTRYLYFLQLKHSVIKGDLKCSSDMAVKLASYALQAEFGDYDALIHTPE-FLD PTPN14_SpurP058_AA IQTLRHEMTRYMYFLQLKSDFIEGILPCNEEQAVTLASFALQAEIGNSDPAKHTVEFYQN PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA VSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYN--QFDSQDFLR PTPN21_HsapP077_AA VSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFD--QYESQDFLQ Pez_DmelP041_AA KSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERF PTPN14_AqueP050_AA DHILFPSEV--------------------------------------------------- PTPN14_SpurP058_AA EYVLLPKNM---TTENVSLSELLLKVMNAHQAKVGMSTCQSELGYIEQAAKLQGYGQESF PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA EYVLFPMDL---ALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIF PTPN21_HsapP077_AA KFALFPVGW---LQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESY Pez_DmelP041_AA AAKDTLGNDLLLGLAINGMVVNADNGRQ--YFPWKEFHTVTIDKRTIKIEQNKLDGGGSI PTPN14_AqueP050_AA -----NGTRIWIGACFIGIFIKHSNGQPTVYFKWPEIVKMKVKDRCFAIET--HHD---- PTPN14_SpurP058_AA PAKDDSGNELFISASFSGLSVKHLNRQETVHFEWHEVVSMGHNRRAFGVGTSRSHD---- PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA PVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEE---- PTPN21_HsapP077_AA PAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEE---- Pez_DmelP041_AA VGSFIFSEADTARYFWKLTISQHKFFKRYI-----DTATPSSLGSGADAESGPLGVDSVG PTPN14_AqueP050_AA SIYFKMADTPTAQYVLEMMVQQHMFFQ--------------------------------- PTPN14_SpurP058_AA VLQFQMEDAETAKYVCRICRLQQQFHK--------YTVETVKLGSREVLVDGFPADKLIT PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA TALFHTDDIENAKYISRLFATRHKFYKQNKICTE-QSNSPPPIRRQPTWSRSSLPRQQPY PTPN21_HsapP077_AA TIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVNPIRRRSS-SRMSLPKPQPY Pez_DmelP041_AA YVDYDYNEAAAAEQLQQHHQQQQHMQQQQ------------------------------- PTPN14_AqueP050_AA -----------TEYLDIKWIAR-------------------------------------- PTPN14_SpurP058_AA VVDPERRLSMDGQQMSGKMRNRDSLILGEGASSEENLPHHMMADGQLGNQQFIIGQTGNT PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA ILPPVHVQC--GEHYSETHTSQDSIFHGN------------------------------- PTPN21_HsapP077_AA VMPPPPQLHYNGHYTEPYASSQDNLFVPN------------------------------- Pez_DmelP041_AA -----------------------QIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLH PTPN14_AqueP050_AA ---------------------------------------------RNGKKKSV------- PTPN14_SpurP058_AA NFTTSQLSLDNQHAYDMGPFTTSQLSLDRPPTDYSYSNGNLVMLDQNGSVYSAPSVNSLN PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA ----------------------EEALYCNSHNSLDL--NYLNGTVTNGSVCSVHSVNSLN PTPN21_HsapP077_AA ----------------------QNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLN Pez_DmelP041_AA SSSGMLHHGGSNNNNNNDERERLKA-----------MLPTYRPAPDYETAV--QLKYRTP PTPN14_AqueP050_AA -----------------------------------------------------SLNDIRL PTPN14_SpurP058_AA YGL-HNQVSPNSSNPSLTNNEKVRA-------HLQASLPAYRQSPDYEAFIQARLQQRLL PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA CSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMR-QMKRGIL PTPN21_HsapP077_AA NPQPYLQPSPMSSNPSITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMK-QLNRGLV Pez_DmelP041_AA SAEFHNVALAMAAPGNAYYAGSQPDVHNP-----------------GMHNENLLYGHMTA PTPN14_AqueP050_AA HALKQS------------------------------------------------------ PTPN14_SpurP058_AA TVSEQSQSVGNL--GKQNGYGHMESVLYPQPELRQHNHNNHYRQQFRLSYGGTPNNYYTG PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA HTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQR PTPN21_HsapP077_AA HAERQSHSLRNLNIGSSYAYSRPAALVYSQPEIREHAQLPSPAAAHCPFS--LSYSFHSP Pez_DmelP041_AA HRYPDVAQPAAA----LHHHINLYQAQHQPQSHPQPMSPAQAYLELSQRMHMMRHKAPPP PTPN14_AqueP050_AA ------------------------------------------------------------ PTPN14_SpurP058_AA NNMDYSLESLQHGLLIKTPHGNIVHTISVPELTSEHIQTTEEYIT-AKLLKNK-YKPPPP PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA NPKNNVVPS-------KPGASAISHTVSTPELANMQLQGSHNYST-AHMLKNYLFRPPPP PTPN21_HsapP077_AA SPYPYPAER-------RP----VVGAVSVPELTNAQLQ-AQDYPS-PNIMRTQVYRPPPP Pez_DmelP041_AA YVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGN-- PTPN14_AqueP050_AA ------------------------------------------------------------ PTPN14_SpurP058_AA Y--PRGSASTPNLAR------QSNNYLVSSSSPDLVSRRLQAIEAMHEVNLHGSGNVNID PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA YPRPRPATSTPDLA-------SHRHKYVSGSSPDLVTRKVQLSVKTFQE----------- PTPN21_HsapP077_AA YPPPRPANSTPDLS---------RHLYISSSNPDLITRRVHHSVQTFQE----------- Pez_DmelP041_AA ------IPTSSGATMLHQYQYVSHMGHSQPYLPPHGTFENLNMIEEQPSIMSQLRQSAMS PTPN14_AqueP050_AA --------------------------------------------DKKKKEAGSLRKTEER PTPN14_SpurP058_AA ADLSQSLPIEAFQQMRIQDYHAQVGMYSRHVSQGYQQQYSPQQREFKPALTLNLTDKAQP PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA --------------------------------------------DSSPVVHQSLQEVSEP PTPN21_HsapP077_AA --------------------------------------------DSLPVAH-SLQEVSEP Pez_DmelP041_AA QAAAAAAGSVVTQSS---PTLPPSGYRSSVPPPASSPLPPPVVASSHKSATPAPLQRSLV PTPN14_AqueP050_AA --ESKFSRPLGKRDSLLEPLSPSHHGLEEDLSPREIVLTTPPGAVSDSTACLTPTA---- PTPN14_SpurP058_AA SDLSMIAVPTGYEDNL--PTPPDKSRIMSPFQEYAGPLVSPPSEFADHSDIDSNMSPGSV PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA LTATKHHGTVNKRHSL--EVMNSMVRGMEAMTLKSLHLPMARRNTLREQGPPEEGS---- PTPN21_HsapP077_AA LTAAR-HAQLHKRNSI--EV-AGLSHGLEGLRLKERTLSASAAEVAPRAVSVGSQPSVFT Pez_DmelP041_AA NGSIEPIYENVPLPQR--------------ASGGSSGAANTEAMRQRASSIQSAPGVVPV PTPN14_AqueP050_AA ------------------------------WMEGAEEREKEEEK--------------PT PTPN14_SpurP058_AA GSPTRHFHLPPHGMGDIYNSQPSLPENHLTYVTGGFGQMNGTGQLGSPTRVYSMPQLHPE PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA ------GSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPESVPQI---------PM PTPN21_HsapP077_AA ERTQREGPEEAEGL-RYGHKKSLSDATMLIHSSEEEEDEDFEEESGARA---------PP Pez_DmelP041_AA PAARNASSNNVVTVTVNSP----PDDGNIKKYGADRAA-STELLFLEPQAPKRTNRAASA PTPN14_AqueP050_AA MKKKRE-----------------KGLGRTGVLECIPVN-EDGIDIGEPICTSPTDMVTVN PTPN14_SpurP058_AA MREQQHHTSEIETILAERKTNQSQGFATSMHANPKDNI-TQETPLNDHTTQSSSPTPALP PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA LREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARVLRHGPA PTPN21_HsapP077_AA ARAR-----EPRPGLAQDP----PGCPRVLLAGPLHIL-EPKAHVPD--AEKRMMDSSPV Pez_DmelP041_AA A--PDMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTSSMFNS PTPN14_AqueP050_AA EATIDTREHHNAVGGEVTSSIPNLSHPLPPPIMHHQVSSANGGSSGSQESFELSHTK--- PTPN14_SpurP058_AA QSTDDVHSHKPKQPELKASSVSSKPSTNPPSTTQQPSTSKASSTPPATSSSNHKQTVASK PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA KAISMSRTDPPAVNG--ASLGPSISEPDL-TSVKERVKKEPVKERPVSEMFSLEDSIIER PTPN21_HsapP077_AA R--TTAEAQRPWRDG--L-LMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEG Pez_DmelP041_AA TLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSATLGREKATTAGQHSKLAAKLKLAQD PTPN14_AqueP050_AA -----------KEYLSASLNQLDSRT--P-------------------PNTLKLTKTPPP PTPN14_SpurP058_AA SPTLPLSPDSEGSEVLEDLGTDNGGYIGP-------------------LKLAAMSGLTLL PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA EMMI-------RNLEKQKMAGLEAQKR-P-------------------LMLAALNGLSVA PTPN21_HsapP077_AA LPPL-------GGMKKTR---VDAKKIGP-------------------LKLAALNGLSLS Pez_DmelP041_AA DLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRR-EHALYECA PTPN14_AqueP050_AA LLSPDTQW-------EQEATSGTRDKRAQHLEMILQSGKVYPEFEEIPPMS-LDADTSAG PTPN14_SpurP058_AA RPRDMPAQ-------PEEETKHPRDARRKILEKQLREGQVFTEYEQITKKR-EGAVCYTS PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA RVSGREEN-------RVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKK-ANGIFSTA PTPN21_HsapP077_AA RVPLPDEG-------KEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTA Pez_DmelP041_AA LLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATVGTKQRFYIVAQSPQE PTPN14_AqueP050_AA SNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGSQHRSYIVCQGPL- PTPN14_SpurP058_AA KLPENVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVKVPVAGELLHYIAAQGPM- PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA ALPENAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKVVVGGAEWHYIATQGPL- PTPN21_HsapP077_AA RLPENAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKVSVSGIEWDYIATQGPL- Pez_DmelP041_AA PLTMRIFWQCVWEADVYLVVQLTED--------MSYIPRN---SHQRLEFGQFQVYQEFS PTPN14_AqueP050_AA EITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEE-NAKHVQFEQYRISTKFV PTPN14_SpurP058_AA ENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKNTAEFGPFRVIAQFS PTPN14_NvecP074_AA ------------------------------------------------------------ PTPN14_HsapP076_AA PHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGS-KHSSATYGKFKVTTKFR PTPN21_HsapP077_AA QNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGS-RHNTVTYGRFKITTRFR Pez_DmelP041_AA QTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQ PTPN14_AqueP050_AA EKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISYLRMVKSLRYKFDE PTPN14_SpurP058_AA NDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSFLEEFQSVCRHANS PTPN14_NvecP074_AA ---------------MPTKQQRTVYHVQFTDWPDHRVPDDPTSFLEFLDQVESLRQRTST PTPN14_HsapP076_AA TDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNS PTPN21_HsapP077_AA TDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNS : : * : :*: **.:: * * *:.:* .:*: Pez_DmelP041_AA EVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIP PTPN14_AqueP050_AA SI--------PIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSSLARLRLQRMHLVQ PTPN14_SpurP058_AA MNE--VEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKMMGILRQQRMLMVQ PTPN14_NvecP074_AA TRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHALVRLRRQRMLLVA PTPN14_HsapP076_AA MLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQ PTPN21_HsapP077_AA TSDP-QSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQ * ::** * **:** : ::: : .: ::: : ** ** :: Pez_DmelP041_AA SLAQYKFIYNLLITYLKRTRLI PTPN14_AqueP050_AA TLGQYRFLYTVIIKYINNARLI PTPN14_SpurP058_AA TVGQYTFVYKALIQSLKNTRLI PTPN14_NvecP074_AA NFGQYRFVYSTVIHYIKNSRLI PTPN14_HsapP076_AA TIAQYKFVYQVLIQFLQNSRLI PTPN21_HsapP077_AA TLCQYTFVYRVLIQFLKSSRLI .. ** *:* :* :: :***