MUSCLE (3.8) multiple sequence alignment PTPN3_MbreP067_AA -----------------MTKSRGTYSVRDAQN-GVATSKSRKRGDYVCVIRHLDNTEHSI PTPN3_AqueP051_AA MAFLKRIPSVRKKNSYRLAAVSPTDRPSSQSV-SESAAAKLSSGLIQCHITLLDDSMFTC Ptpmeg_DmelP043_AA -----------MFERFRLNNLTRTFRLRGGGP-ELARDKKTPQRQQCVTVLFLDDITHTF PTPN3_NvecP076_AA --------MFEFKRKFRSASHSGMYSVRGSEL---ARTGNTNPQKIRCVVELLDDSEFII ptp-1_CeleP159_AA ----------------MRLG-SNSYDVQRTEAIGQTPVKTPPPNQIRCTVTFLDSTSYHF PTPN3_HsapP080_AA MMLRGGYSAIVMTSRLRALG-GRINNIRTSEL-----PKEKTRSEVICSIHFLDGVVQTF PTPN4_HsapP081_AA -----------MTSRFRLPA-GRTYNVRASEL-----ARDRQHTEVVCNILLLDNTVQAF PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA YISGKATGDEVFRAFLREIEPLPETDYFALYFPSKSR----------------------- PTPN3_AqueP051_AA DLNKHSLGSTLLDEVYAHAD-IIERDYFGL---SYSENGY--------NKWLQSDKPLKK Ptpmeg_DmelP043_AA RIEKRAKGSELLDQVFQYLE-LSERDYFGLLFPQKPGDV---------VRWVDAQKQFKK PTPN3_NvecP076_AA DVDKNAKGTVLLNEVFRHLD-IQEKHYFGL---QYVSDSPDNMVGGAKEQWLQDDKIIRK ptp-1_CeleP159_AA EIEKNSLGIVLLEKVFNYLE-IIEKDYFGLVFIAVDNSSAQQ------KKWLDPSKNLRK PTPN3_HsapP080_AA KVTKQDTGQVLLDMVHNHLG-VTEKEYFGL---QHDDDSVDS------PRWLEASKAIRK PTPN4_HsapP081_AA KVNKHDQGQVLLDVVFKHLD-LTEQDYFGL---QLADDSTDN------PRWLDPNKPIRK PTPN3_SpurP061_AA ----------------MHLK-TNIEDTLG------------------------------- :. PTPN3_MbreP067_AA ------------TVTLEFGVKFFVADPRQLQHDHTRFLYYCQLKEDLASGRFVAPHDVCW PTPN3_AqueP051_AA Q-----FKGGSCSVVLELRVKFYTSDPVFLVEELTRYLFFRQIKKDLLENRLICPTEAAA Ptpmeg_DmelP043_AA QCSSVSLDNDA-VPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQC PTPN3_NvecP076_AA Q-----KKGTP-PYIFYFCVRFFVSDPSKLVEDLTRYYFYLQIKRDILTGRLPCLYDTAA ptp-1_CeleP159_AA Q-----MI-CP-PYHLFFRVKFYVRDPNRLRDEFTRFQFYQQVRQNLEEGRLPCNEGSLA PTPN3_HsapP080_AA Q-----LKGGF-PCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAV PTPN4_HsapP081_AA Q-----LKRGS-PYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAA PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA QLCAYIVQADIGDFNISRC--PEGYLSDMLLLPDQKPEDEDEIRNLHVQLEDMTADEAML PTPN3_AqueP051_AA ILSAFALQAELGDYDPVGH--PPGYVSEFRFISNQDEVFEKRVSEIHQEIRGQTTSEAEY Ptpmeg_DmelP043_AA LLASYTVQSELGDFNALEH--QPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEY PTPN3_NvecP076_AA ELSSYILQAELGDYDPKLH--LDGYVSEFRFIPDQTDDFEERAAEFHKHHIGQTPADAEF ptp-1_CeleP159_AA LLASYVVQAEVGDFEEKTHGMSRTCLCYKIQFATLPDDFSDRVAELHQLHIGQTPDVAEQ PTPN3_HsapP080_AA VLASYAVQSHFGDYNSSIH--HPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAES PTPN4_HsapP081_AA LLASFAVQSELGDYDQSEN--LSGYLSDYSFIPNQPQDFEKEIAKLHQQHIGLSPAEAEF PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA AFLELASQQLLYGLDIHPVMLSNRLPGYIGIGWRGIRIMSDTMATVEFFPWARFQMITFD PTPN3_AqueP051_AA NFLQYARQLEFYGVEQYPAADDRGVSISLG------------------------------ Ptpmeg_DmelP043_AA NYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSL-RVNTFSWSKMVKVSFK PTPN3_NvecP076_AA NFLEVAKTLDLYGVDLHCAKDHDGTDLFLGVSALGLTVYHNKC-KINFFPWSKIVKVCFK ptp-1_CeleP159_AA NFLDHARRLEMYGMDVYDGVDANHLPIEIGVGAVGIKVFHEGI-KMNEYAWVRIRKLSFK PTPN3_HsapP080_AA CYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYI-CTSFYPWVNILKISFK PTPN4_HsapP081_AA NYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRV-RMNTFPWLKIVKISFK PTPN3_SpurP061_AA ------------------------SEIAIGVVSAGLSIFQNGV-RINQFSWAKIVKISFK :* PTPN3_MbreP067_AA NRVVDLVTKGQLNGPDTHNV-VTCTTKQHAQALWIAGVQRHTFFRRRRQPQLKTS--GLF PTPN3_AqueP051_AA -------------EMDERVVGFHMDNHEASKRLWVACIEHHAFFRMSEVSKGPQR----- Ptpmeg_DmelP043_AA RKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRF---LN PTPN3_NvecP076_AA RKRFFIQIRPDWNEWTDNIIGFQMLTYRSCKNLWKVCVEYHSFYRTHYPKATEKR----V ptp-1_CeleP159_AA KKQFQVLVANEDGVS-ETIMIFNIMSAKICKLLWKCCIEQHTFFRLKTPPKTPQR---KV PTPN3_HsapP080_AA RKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQY PTPN4_HsapP081_AA CKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHY PTPN3_SpurP061_AA RKQFFIQQRREIGETRDMVIGFNMTSYRACKNLWKSCVEHHTFFRMVDPQPPAKR--RTF : . . .: ** :: *:*:. PTPN3_MbreP067_AA DRSHEALRRAHISPLGRTQEQILTEVKSSLEFSTTFTPRPVTRNRHARMQRVGTGASRSY PTPN3_AqueP051_AA ---GSPFRKSKVKITRKTEKQVVEASK-SIARDGQRIRRTPSKRYPKRSPLVGDN----- Ptpmeg_DmelP043_AA ISLGSKFYYS-----GRTELQAVQESK-QRGRIHKVFVRSPSKRLLGAAGGVGT------ PTPN3_NvecP076_AA LRMGSKYRYK-----GKTEYQAIEESR-THARPEPKIVRTLSRRYS-KRSDSGT------ ptp-1_CeleP159_AA FNFGSKFRYS-----GRTEYQTLEENEHRKSAGHRNFHRSLSKSSFLRSTFSGNTQSIDS PTPN3_HsapP080_AA WTMGS-----------------------------RNTKKSVNNQYC-KKVIGGMV----- PTPN4_HsapP081_AA FTLGSKFRYC-----GRTEVQSVQYGK-EKANKDRVFARSPSKPLARKLMD--------- PTPN3_SpurP061_AA FQLGSKFRYS-----GRTESQTMEDTK-KRLAEKEISRSSPNKRAF-RRTVGGTV----- . . .. PTPN3_MbreP067_AA TGVARESIYRHRSASVPTLNLSFASWSSHRPGSVQPTAGSVKRHSADFSVLDPVPAAHNQ PTPN3_AqueP051_AA -------------------------DDLMR------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA -------------------------W---------------------------------- ptp-1_CeleP159_AA SRYTNTTTTDSPELPSS--------GQLLA------------------------------ PTPN3_HsapP080_AA -------------------------WNPAM------------------------------ PTPN4_HsapP081_AA -------------------------WEVVS------------------------------ PTPN3_SpurP061_AA -------------------------AEVIR------------------------------ PTPN3_MbreP067_AA SLISANLDDAVPPTQARTAFAPRTFAASPERSLGIGVMSTFAHAEEAALMAETEILVDTH PTPN3_AqueP051_AA ----------------RRANTEIRR----TGSLRDYGGGR-------------------- Ptpmeg_DmelP043_AA -----------------------------SGSSG----GT-------------------- PTPN3_NvecP076_AA -----------------------------SRSLR----RL-------------------- ptp-1_CeleP159_AA ----------------RRLLSAARHDTDSSDALGYASDGAVVCAPLTT------------ PTPN3_HsapP080_AA ----------------RRSLSVEHLE---TKSLP----SR------SP------------ PTPN4_HsapP081_AA ----------------RNSISDDRLE---TQSLP----SR------SP------------ PTPN3_SpurP061_AA ----------------TE-----------TRSLP----SR--TTQKYK------------ : PTPN3_MbreP067_AA DTVELKPFAQGVHEPRVALVRNVDELNEFGGPHALPVRASFHAPTMSESNQPSAVHLNFL PTPN3_AqueP051_AA -----------------------------------PVVEVRRGQSPSELT---------- Ptpmeg_DmelP043_AA -----------------------------------PMQQHSGSESANSHN---------- PTPN3_NvecP076_AA -----------------------------------DLDREFEKDSMYGEK---------- ptp-1_CeleP159_AA -----------------------------------PLSPRRTRDYATDSE---------- PTPN3_HsapP080_AA -----------------------------------PITPNWRSPRLRHEI---------- PTPN4_HsapP081_AA -----------------------------------PGTPNHRNSTFTQEGT--------- PTPN3_SpurP061_AA -----------------------------------PLKDNHRVPSFDGEI---------- PTPN3_MbreP067_AA PPPPAADESTFHGRLIAAAEVAEDRLAYYRVLRTVHYGDVVLHPSDIVGLTTDVMRAGDH PTPN3_AqueP051_AA PRRLSA------------------------------------------------------ Ptpmeg_DmelP043_AA NGKPAGAG---------------------------------------------------- PTPN3_NvecP076_AA HAPPF------------------------------------------------------- ptp-1_CeleP159_AA SSAPSLRQQRLSKEAIYYGTQESCDE---------------------------------- PTPN3_HsapP080_AA RKPRHSSADNLANEMTYITETEDV-----------------FYTY--------------- PTPN4_HsapP081_AA RLRPSSVG---------------------------------------------------- PTPN3_SpurP061_AA PPSPNG------------------------------------------------------ PTPN3_MbreP067_AA CEVYLLPSLAKHVTLHPEGGMAQKEGPFDDVEQGLGILTTPEQSPLALKELPTVTRLSTM PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA MAGMRQRELTEHRDDAQRDTTVVYEPVSVHAAVTAPRPVVLLGAGKANVEAALLERFPDA PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA YRLVRHDATDSHGEAESYRFVDLDTFIHQAMRDEYAEVVRYGSDLYGLPYASLRTDEDGR PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA HPVIPICDPLVITTLQKHGVFPIVIFLDCDTSRRARLVMPHDSASRVHAEVQLAAKVKSH PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA FHAYFSGQVFPANSLEDVAEVVHEVVSTVQLHPFWIPSRLHLMSGVDLNLDLLELDRKPL PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA --------------------------------------------------------KGSL PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA QPVSVDTVATTPGPSVPIRARSRVTAMPMIYDEDEAEDEATTGPVPVEKTDVGETAVEAT PTPN3_AqueP051_AA -TREHTPAMSSPRSPLSEAEDDFTAADFLQFQLGETEES---GFTTL------------- Ptpmeg_DmelP043_AA TILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQ------------- PTPN3_NvecP076_AA ------HYASAPNSTEKLDRTNFKRSLSTSANVGATKS----GLTPE------------- ptp-1_CeleP159_AA KSWTPSMACTSTSPGIHASTASVRPVSSGSTPNGASRKSANSGYSGY--------GYATQ PTPN3_HsapP080_AA APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGS------------- PTPN4_HsapP081_AA HLVDHMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPPA------------- PTPN3_SpurP061_AA KPRE--NGLSKSAEMLNVP-----PQMTYMDDNGGSDVSIGTGNSYE------------- . . PTPN3_MbreP067_AA SEATSKDVDSRPSSAVSRTIVDDESGFWATESIRIPRTIAGYGFGFREGSESWCQNLPVV PTPN3_AqueP051_AA --------------QISDRHNHHHDK------------EVGEYYDESNAAEEFANQMTID Ptpmeg_DmelP043_AA ---------------CTRRFESASPS------------PMPPAYSSGQHSPILLPTTIAD PTPN3_NvecP076_AA --------------------------------------LQANGSTPQEG----------- ptp-1_CeleP159_AA TQQPTSTTNASYSPYLNGTISRSSGAAVAKAAARGLPPTNQQAYNTSSPRNSVASYSSFA PTPN3_HsapP080_AA ---------------CSPDGVDQQ--------------LLDDFHRVTKGGSTEDASQYYC PTPN4_HsapP081_AA ---------------LPPKQSKKNSW------------NQIHYSHSQQDLESHINETFDI PTPN3_SpurP061_AA --------------------------------------VLSNGYKSQTNGDA-------- PTPN3_MbreP067_AA TSITAGGAAHLDGRLQSEDVLVEVNGKGLASKSYVEVLTMIRGHSGALRMTVKRRCKEVT PTPN3_AqueP051_AA DLASEG----------------------FLM----------------IRLNPD------- Ptpmeg_DmelP043_AA AVGHQQPESGSD----------------LIT----------------IRLQAD------- PTPN3_NvecP076_AA ----------------------------LIT----------------VRMEPD------- ptp-1_CeleP159_AA SAGIGGSPPRSKRSPQSNKSSSPVGEDQVVT----------------IKMRPD------- PTPN3_HsapP080_AA DKNDNGDSY-------------------LVL----------------IRITPD------- PTPN4_HsapP081_AA PSSPEKPTPNGGIPHDN-----------LVL----------------IRMKPD------- PTPN3_SpurP061_AA ----------------------------LVT----------------IRMLPD------- . :.: . PTPN3_MbreP067_AA LLARDGKYGMGIRGGADSKTPVLISRIAEGSAAAD-EPQIQIGEEITHINGTDVTQLTHA PTPN3_AqueP051_AA ---SEGRFGFHVKGGLDLNLPVFVSKVKEDSPASQCQPPLEEGDQVLFVNGMSTDTATHI Ptpmeg_DmelP043_AA ---EQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHE PTPN3_NvecP076_AA ---KEGRFGFNVQGGADINLPVIVSKIARGTPADLCMPQLQEGDEIIFINGQAMKGLIHQ ptp-1_CeleP159_AA ---RHGRFGFNVKGGADQNYPVIVSRVAPGSSADKCQPRLNEGDQVLFIDGRDVSTMSHD PTPN3_HsapP080_AA ---EDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHD PTPN4_HsapP081_AA ---ENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHD PTPN3_SpurP061_AA ---DRGRFGFNVKGGADQGAPIIVSRVAPNTPADLCIPRLNEGDQILQINGKDASTFTNE *.:*: :.** * *: :*.: :.* * : *::: ::* : PTPN3_MbreP067_AA EVLALIKS-----SPSSLNLVIHPR---RPKNRRHKDDEPVFRRASALPDVDEQPETDAG PTPN3_AqueP051_AA EVITAIKSSLDR-QPPQLVLIIKPRDLSRVDPTASGDSAPQF------------------ Ptpmeg_DmelP043_AA QVVAMIRDCRHQ-ASGELLLTVRPQRS-APLL---LEEEPLY------------------ PTPN3_NvecP076_AA EIVDLIRSVSQS-RSNTLILTIRPNVF-APNGSRSLDDSPVH------------------ ptp-1_CeleP159_AA HVVQFIRSARSGLNGGELHLTIRPNVY-R--LGEEVD-EPDS------------------ PTPN3_HsapP080_AA QVVMFIKASRES-HSRELALVIRRRAV-RSFADFKSE-DELN------------------ PTPN4_HsapP081_AA QVVLFIKASCER-HSGELMLLVRPNAV-YDVVEEKLENEPDF------------------ PTPN3_SpurP061_AA QLVSTIRALGEA-RTKDLVLTVRPNEI-YVYVGEEVE-EPVF------------------ :: *. * * :. . : PTPN3_MbreP067_AA DQPMVMATSFSAADMEDSRGVSTFSSASATAPAPPERRTSILREFGQLDTSTTVDDAAVG PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA SLEGVSDTPMESGDARTFSTFGVVSSPGSLSTFGTEPQPIASSVQDSEPVSAPVVPVAPA PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA QPEQVVPDEPVTLTSFGVGNNQSSEPTAPTARPTAPPTAPPAAPPTAPPTAPPTAPPTVT PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ---QYVPE---------------------------------------------------- PTPN3_NvecP076_AA ---TVSVE---------------------------------------------------- ptp-1_CeleP159_AA ---TMVPE---------------------------------------------------- PTPN3_HsapP080_AA ---QLFPE---------------------------------------------------- PTPN4_HsapP081_AA ---QYIPE---------------------------------------------------- PTPN3_SpurP061_AA ---QYIPE---------------------------------------------------- PTPN3_MbreP067_AA PVTDSSSSSGSAAPPPPPPPGPAPAALTASPTKIVVKKRESDSDDKPKPIKQSSQADLQD PTPN3_AqueP051_AA ------------------------------------------------------SSDPHT Ptpmeg_DmelP043_AA ------------------------------SDE---------------IGSHSNLLDGDA PTPN3_NvecP076_AA ------------------------------QYNAQELKHEKEVEAALVSKREKQQQRDCE ptp-1_CeleP159_AA ------------------------------P-----------------A-RVADSVPNSD PTPN3_HsapP080_AA ------------------------------A-----------------IFPM--CPEGGD PTPN4_HsapP081_AA ------------------------------K-----------------A-PLDSVHQDDH PTPN3_SpurP061_AA ------------------------------S-----------------P-RI--VNGEID PTPN3_MbreP067_AA QLLAATQRRRKMLEDGPSEPAQTAAAHEATPPSPPRTPHTVFTSSPSLERSEVAESNSKT PTPN3_AqueP051_AA LLRESMVSLKESVLNG-----------------------SVLVSFDRLYR---------- Ptpmeg_DmelP043_AA LFTQSLLLLSDGLASG-----------------------ALLAQYELMYR---------- PTPN3_NvecP076_AA GLKVSIEQLRENLESG-----------------------DLLVYFQELYR---------- ptp-1_CeleP159_AA KLSKSLQLLADSLNSG-----------------------KVVDHFEMLYR---------- PTPN3_HsapP080_AA TLEGSMAQLKKGLESG-----------------------TVLIQFEQLYR---------- PTPN4_HsapP081_AA SLRESMIQLAEGLITG-----------------------TVLTQFDQLYR---------- PTPN3_SpurP061_AA SLTESFMLLQEGLDTG-----------------------MAIAQFDQLYR---------- : : . : * . : * PTPN3_MbreP067_AA ATPPPVAKKPSRPTIADKPTKPAVATKPEVATKPEVATKPEVATKPEVATKPEVATKPEV PTPN3_AqueP051_AA -------KKPGMLTIASK------------------------------------------ Ptpmeg_DmelP043_AA -------KNPDLAITEAR------------------------------------------ PTPN3_NvecP076_AA -------KKPGMAMDDAR------------------------------------------ ptp-1_CeleP159_AA -------KKPGMSMNICR------------------------------------------ PTPN3_HsapP080_AA -------KKPGLAITFAK------------------------------------------ PTPN4_HsapP081_AA -------KKPGMTMSCAK------------------------------------------ PTPN3_SpurP061_AA -------KKPGMTMGACR------------------------------------------ *:*. . PTPN3_MbreP067_AA ATKPDVASKPAATAKPTGADASMAVDNKASEEEAPTEQASIESEPAAPAPVPVPRERRPS PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA QPTETETETETETETESAAPAPKPRPANGKSSNPFAAMKNNPFTKSKLRQEMSAPRQMGN PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA KPLPVPKRGSTSAMSETTASSSKASSLTAQLPKPAPTKAEPESEPVPPPRPSLSAGSGGN PTPN3_AqueP051_AA ------------------------------------------------------------ Ptpmeg_DmelP043_AA ------------------------------------------------------------ PTPN3_NvecP076_AA ------------------------------------------------------------ ptp-1_CeleP159_AA ------------------------------------------------------------ PTPN3_HsapP080_AA ------------------------------------------------------------ PTPN4_HsapP081_AA ------------------------------------------------------------ PTPN3_SpurP061_AA ------------------------------------------------------------ PTPN3_MbreP067_AA NNGPRIVTGSFPAISAMRRGLVKSRDCSLALKPENAVRNRYRDILPYDDTRVKLDSSNN- PTPN3_AqueP051_AA -------------------------------LPQNLSKNRYRDITAYDITRVHLLDGPV- Ptpmeg_DmelP043_AA -------------------------------KPANAPKNRYRDISPYDCTRVSLVNSLTG PTPN3_NvecP076_AA -------------------------------KPENLPKNRYRDILPYDETRVKLFKGS-- ptp-1_CeleP159_AA -------------------------------LTANLAKNRYRDVCPYDDTRVTLQASPSG PTPN3_HsapP080_AA -------------------------------LPQNLDKNRYKDVLPYDTTRVLLQGNE-- PTPN4_HsapP081_AA -------------------------------LPQNISKNRYRDISPYDATRVILKGNE-- PTPN3_SpurP061_AA -------------------------------LAENVAKNRYRDIAPYDATRVILREADTG . * .***.*: .** *** * PTPN3_MbreP067_AA DYINANHLSFE--SNGTTFSYIASQAKH------FWQMVWEQQVRLICMLTTLVEGGRTK PTPN3_AqueP051_AA DYINANYVNMDIPSTCQVVRYIVTQGPMQNTCIDFWQMVWEQGCGFIVMLTDIMEEGKVK Ptpmeg_DmelP043_AA DYINANYVNMEIPG-GAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQK PTPN3_NvecP076_AA DYINANFVNMEVPSHGIVLRYIAAQGPLEKTCGDFWQMIWEQESTLVIMLTTTMERGRVK ptp-1_CeleP159_AA DYINANYVNMEIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVK PTPN3_HsapP080_AA DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTK PTPN4_HsapP081_AA DYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVK PTPN3_SpurP061_AA DYINANTINMDIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVK *****. :.:: . *:. *. ** : .:: : *** * *. * PTPN3_MbreP067_AA CHQYWPSAPGDTCQFGD-FSIVLNKE--AARKGYILRDITVQRANAKGKRRLFQLQFTAW PTPN3_AqueP051_AA CCRYWPD-QGNSTEYGP-FQIYCESD--RKDNLCCTRHFVLKNNRTKEEKPIIHLQFLDW Ptpmeg_DmelP043_AA CHQYWPV-TGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKH--EQRHIHHMQYLAW PTPN3_NvecP076_AA CHQYWPE-GEDTWTFGN-LEVVCNKIR-DFSPSYVYREMYVTDTTTLRSRVIIQLQYLAW ptp-1_CeleP159_AA CHQYWPR-VFETQEYGR-LMIKCIKD--KQTTNCCYREFSIRDRNSSEERRVTQMQYIAW PTPN3_HsapP080_AA CHQYWPD-PPDVMNHGG-FHIQCQSE--DCTIAYVSREMLVTNTQTGEEHTVTHLQYVAW PTPN4_HsapP081_AA CHQYWPE-PTGSSSYGC-YQVTCHSE--EGNTAYIFRKMTLFNQEKNESRPLTQIQYIAW PTPN3_SpurP061_AA CHKYWPD-LDDRLKFGPDLEVRCTRC--DETPSFAYRDFIICNTATKEERIVLQMQYVAW * .*** . : * : : .. : ::*: * PTPN3_MbreP067_AA PDHGLPTSSAEMLTLVKEINNLKSR----------------------------------- PTPN3_AqueP051_AA SESNVPLVKADFLRFIRRLHTLR------------------------------------- Ptpmeg_DmelP043_AA PDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCA PTPN3_NvecP076_AA PDHDVPDDATDFLEFVHSVRHYR------------------------------------- ptp-1_CeleP159_AA PDHGVPDDPKHFIQFVDEVRKAR------------------------------------- PTPN3_HsapP080_AA PDHGVPDDSSDFLEFVNYVRSLR------------------------------------- PTPN4_HsapP081_AA PDHGVPDDSSDFLDFVCHVRNKR------------------------------------- PTPN3_SpurP061_AA PDHGVPDDSSDFLDFVLRVRQCR------------------------------------- .: :* :: : :. . PTPN3_MbreP067_AA ---------------------LVKPMPLLVHCSAGIGRTGVYILLELCLHQLQEKAKEVN PTPN3_AqueP051_AA ---------------------HGMEDPLVVHCSGGIDRSGIFVAMETALT-KIEIVEAFN Ptpmeg_DmelP043_AA ASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALA-LMEAREPVY PTPN3_NvecP076_AA ---------------------EGTSTPAVVHCSAGVGRSGVLMFIETAFG-MIEGAEPVY ptp-1_CeleP159_AA ---------------------QGSVDPIVVHCSAGIGRTGVLILMETAAC-LVESNEPVY PTPN3_HsapP080_AA ---------------------VDSE-PVLVHCSAGIGRTGVLVTMETAMC-LTERNLPIY PTPN4_HsapP081_AA ---------------------AGKEEPVVVHCSAGIGRTGVLITMETAMC-LIECNQPVY PTPN3_SpurP061_AA ---------------------VGMDVPTIVHCSAGIGRTGVLITMETAMC-LIEANEPVY * :****.*:.*:*: : :: . * . PTPN3_MbreP067_AA IPAILSQLREQRMNLVQTQDQYKFVCGTVMALSKGAGPGFKVCP--------- PTPN3_AqueP051_AA PLEIVRMMRDQRGMMLPALNQYKFFCDCIVQAYEEDYIEIDLSNHANNVKTSP Ptpmeg_DmelP043_AA PLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKISRSSAAINDDED----- PTPN3_NvecP076_AA PLELVRRMRDQRGSLIQTPGQFLFVCEATLKAYDDEVVRPLPIS--------- ptp-1_CeleP159_AA PLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDGTIKPLAEYSKR------ PTPN3_HsapP080_AA PLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS--------- PTPN4_HsapP081_AA PLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSTNK------ PTPN3_SpurP061_AA PLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMDCIVKPIDEQRS------- :: *:** :: *: *.*