MUSCLE (3.8) multiple sequence alignment PTPN6-1_AqueP058_AA_103-225 NNEGHLPRDGEVKDHLNLEQDFEEL------PSYLYSQDKGNKIQNIHKNRYNASIPF-D PTPN6-3_AqueP054_AA_103-385 NNEGHLPREGEVKDHLNLEQDFEEL------PSYLYSQDKGNKIQNIHKNRYNASIPF-D ptp-2_CeleP160_AA_256-582 ----------ESMEKTGISEEFDRLSQEALPAEQYLSKREGRRPVNAEKNRYKNIVPF-D PTPN6_MbreP068_AA_224-493 -------ETEEEFGKAGFNEEFEQLQTME--HQHKFDRMEGARIENKSKNRYKNILPY-D PTPN6-2_AqueP053_AA_216-506 RVEELRQPNDELFGKTGFEEEYQQLQHEG--TQHLYTRKEAGKPLNRQKNRFKNILPF-D PTPN6_NvecP163_AA_0-140 ------------------------------------------------------------ PTPN6-5_AqueP056_AA_221-510 RVSELEKPSGFSFGKSGFFEEFEELQKID--SMFRKSRKIGVKPENKPKNRFKNIVPY-D PTPN6-4_AqueP055_AA_218-522 RVSELEKQNQDMYGKAGFWEEFEQMQQQE--TRHLYSRKEGVKPENRPKNRFKNILPF-D PTPN6-6_AqueP057_AA_218-510 RVSELEKETGDIMGKAGFWEEFEQLQQQE--CRHLFSRKEGARVENKTKNRYKNILPF-D PTPN6_HsapP086_AA_226-517 VLELNKKQESEDTAKAGFWEEFESLQKQE--VKNLHQRLEGQRPENKGKNRYKNILPF-D PTPN11_HsapP085_AA_229-527 VRELSKLAETTDKVKQGFWEEFETLQQQE--CKLLYSRKEGQRQENKNKNRYKNILPF-D csw_DmelP045_AA_317-747 --------RVEQLVKGGFWEEFESLQQD---SRDTFSRNEGYKQENRLKNRYRNILPY-D PTPN6-3_SpurP065_AA_220-449 EVLEKETKSRENSKKAGFEEEFEALQLLD--NKHLLPRKIGDKAENKSKNRYKNILPY-- PTPN6-1_SpurP063_AA_194-353 -------------------------------------------SDWMCKDCIICIFPFID PTPN6-2_SpurP064_AA_365-510 ----------------GV-----------------------------------------D PTPN6-1_AqueP058_AA_103-225 DNVISLK---EPSVYGSTYINASPIK---------------------------------- PTPN6-3_AqueP054_AA_103-385 DNVISLK---EPSVYGSTYINASPIK---------------------------------- ptp-2_CeleP160_AA_256-582 HTRVILTD--RPNTPGSDYINASYVR---------------------------------- PTPN6_MbreP068_AA_224-493 HTRVKLRNV-PDGVIGADYINANFI----------------------------------- PTPN6-2_AqueP053_AA_216-506 HTRVVLA---EPDSSGNTYINANYV----------------------------------- PTPN6_NvecP163_AA_0-140 ------------------------------------------------------------ PTPN6-5_AqueP056_AA_221-510 DTLVTLL---DPPVPDETYINASYV----------------------------------- PTPN6-4_AqueP055_AA_218-522 HTRVILKDGYDPDVPGSDYINANYI----------------------------------- PTPN6-6_AqueP057_AA_218-510 HTRVVLHGG-DPSIVGSDYINANYI----------------------------------- PTPN6_HsapP086_AA_226-517 HSRVILQGR-DSNIPGSDYINANYI----------------------------------- PTPN11_HsapP085_AA_229-527 HTRVVLHDG-DPNEPVSDYINANII----------------------------------- csw_DmelP045_AA_317-747 HTRVKLLDV-EHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQR PTPN6-3_SpurP065_AA_220-449 ------------------------------------------------------------ PTPN6-1_SpurP063_AA_194-353 HSRVIIND----GLPG-DYINGNYIDLP-------------------------------- PTPN6-2_SpurP064_AA_365-510 HSRVII----NDGLPG-DYINGNYIDLP-------------------------------- PTPN6-1_AqueP058_AA_103-225 ----------------------------------------------------TASTGGLQ PTPN6-3_AqueP054_AA_103-385 ----------------------------------------------------TASTGGLQ ptp-2_CeleP160_AA_256-582 ---------------------------------------------FENSQRTKNVTFACE PTPN6_MbreP068_AA_224-493 ----------------------------------------------------NGEAPGTD PTPN6-2_AqueP053_AA_216-506 ----------------------------------------------------NGEVPGSG PTPN6_NvecP163_AA_0-140 ------------------------------------------------------------ PTPN6-5_AqueP056_AA_221-510 ----------------------------------------------------SGEVPGSE PTPN6-4_AqueP055_AA_218-522 ----------------------------------------------------SGETPDSD PTPN6-6_AqueP057_AA_218-510 ----------------------------------------------------SGEVPGSE PTPN6_HsapP086_AA_226-517 ----------------------------------------------------KNQLLGPD PTPN11_HsapP085_AA_229-527 ----------------------------------------------MPEFETKCNNSKPK csw_DmelP045_AA_317-747 NCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPG PTPN6-3_SpurP065_AA_220-449 ----------------------------------------------------NIKVDQLD PTPN6-1_SpurP063_AA_194-353 -------------------------------------------KAWKNSIELQQQGENVE PTPN6-2_SpurP064_AA_365-510 -------------------------------------------KAWKNSIELQQQGENVE PTPN6-1_AqueP058_AA_103-225 AQ---------------------------------------------------------- PTPN6-3_AqueP054_AA_103-385 AQ---------------------------------------------------------- ptp-2_CeleP160_AA_256-582 KS---------------------------------------------------------- PTPN6_MbreP068_AA_224-493 KA---------------------------------------------------------- PTPN6-2_AqueP053_AA_216-506 NY---------------------------------------------------------- PTPN6_NvecP163_AA_0-140 ------------------------------------------------------------ PTPN6-5_AqueP056_AA_221-510 NC---------------------------------------------------------- PTPN6-4_AqueP055_AA_218-522 CE---------------------------------------------------------- PTPN6-6_AqueP057_AA_218-510 KH---------------------------------------------------------- PTPN6_HsapP086_AA_226-517 EN-------------------------------------------------------AKT PTPN11_HsapP085_AA_229-527 KS---------------------------------------------------------- csw_DmelP045_AA_317-747 SSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKT PTPN6-3_SpurP065_AA_220-449 SN---------------------------------------------------------- PTPN6-1_SpurP063_AA_194-353 KI-------------------------------------------------DMSWEHQKR PTPN6-2_SpurP064_AA_365-510 KI-------------------------------------------------DMSWEHQKR PTPN6-1_AqueP058_AA_103-225 YIATQGPL----DTTISDFWRLVWQEQSSIIIMLTELVEL-------------------- PTPN6-3_AqueP054_AA_103-385 YIATQGPL----DTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEIPEVLHG ptp-2_CeleP160_AA_256-582 FIATQGCL----ETTISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEVNKPEVHG PTPN6_MbreP068_AA_224-493 YIASQGTM----PDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSERRPARFG PTPN6-2_AqueP053_AA_216-506 YIATQGCL----PGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGETTL-YG PTPN6_NvecP163_AA_0-140 ------------------------------------------------------------ PTPN6-5_AqueP056_AA_221-510 YIAAQGCL----QSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTIDDEMIYG PTPN6-4_AqueP055_AA_218-522 YIATQGCL----PATVNDFWRMVWQEGSLVIVMITNEVERGRNKCSRYWPSPESPEETYG PTPN6-6_AqueP057_AA_218-510 YIATQGCL----PTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINETGE-YG PTPN6_HsapP086_AA_226-517 YIASQGCL----EATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRA-YG PTPN11_HsapP085_AA_229-527 YIATQGCL----QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKE-YG csw_DmelP045_AA_317-747 YIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQ-FG PTPN6-3_SpurP065_AA_220-449 ------CV--------------------------------AINKCCRYWPDANTKKD-TG PTPN6-1_SpurP063_AA_194-353 YIATQGCL----KDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKD-TG PTPN6-2_SpurP064_AA_365-510 YIATQGCL----KDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKD-TG PTPN6-1_AqueP058_AA_103-225 ------------------------------------------------------------ PTPN6-3_AqueP054_AA_103-385 KILISSLEE-T---------------------------------TLDYYTMRHFLLSHE- ptp-2_CeleP160_AA_256-582 DISLTCTIERKVQRAVSDEVKAELEQEKTNRIAKGLVPEAELNGDGISYILRTLVMK--- PTPN6_MbreP068_AA_224-493 NYVVELLTE-D---------------------------------NFDAYTVRRMSVAV-- PTPN6-2_AqueP053_AA_216-506 NIQVINIDE-I---------------------------------QGRLYVFRKLHIEHV- PTPN6_NvecP163_AA_0-140 VYHIKHIQE-T---------------------------------ELPHYILREFEI-WI- PTPN6-5_AqueP056_AA_221-510 EVNVKLVAE-K---------------------------------GQFQYILRQFRVCK-- PTPN6-4_AqueP055_AA_218-522 LIHVTSLEEDT---------------------------------ANSHYILRHFLVEKRA PTPN6-6_AqueP057_AA_218-510 DISVQNATE-C---------------------------------INPHYIYREFIIHRI- PTPN6_HsapP086_AA_226-517 PYSVTNCGE-H---------------------------------DTTEYKLRTLQVSPL- PTPN11_HsapP085_AA_229-527 VMRVRNVKE-S---------------------------------AAHDYTLRELKLSKV- csw_DmelP045_AA_317-747 HARIQCVSE-N---------------------------------STSDYTLREFLVSW-- PTPN6-3_SpurP065_AA_220-449 VITVTHISE-Q---------------------------------SMADYDLREFSMSHK- PTPN6-1_SpurP063_AA_194-353 VITVTHISE-Q---------------------------------SMADYDLREFSMSHK- PTPN6-2_SpurP064_AA_365-510 VITVTHISE-Q---------------------------------SMADYDLREFSMSHK- PTPN6-1_AqueP058_AA_103-225 ------------------------------------------------------------ PTPN6-3_AqueP054_AA_103-385 ---------------EKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETS-- ptp-2_CeleP160_AA_256-582 ---------------KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAQ PTPN6_MbreP068_AA_224-493 ---------------GEGDPREIYQYHYTSWPDHGVPPERE-FLQLIMKIRQHRDRLR-- PTPN6-2_AqueP053_AA_216-506 ----------S----KKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQ-- PTPN6_NvecP163_AA_0-140 ----------D----SNPIPRSVYQFHYTGWPDHGVPKDPSPVLSILQEVDIKQKAVP-- PTPN6-5_AqueP056_AA_221-510 ---------------GDETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDFE-- PTPN6-4_AqueP055_AA_218-522 PDAPEEDGGDE----GAYESRHIFQFHFKAWPDHGVPQDPGVVLAFMQDVNMKVQQLR-- PTPN6-6_AqueP057_AA_218-510 ----------E----DPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELV-- PTPN6_HsapP086_AA_226-517 ----------D----NGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP-- PTPN11_HsapP085_AA_229-527 ----------GQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIM-- csw_DmelP045_AA_317-747 ---------------RDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLA-- PTPN6-3_SpurP065_AA_220-449 ----------D----FPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFP-- PTPN6-1_SpurP063_AA_194-353 ----------D----FNKCCR--------YWPD--------------------------- PTPN6-2_SpurP064_AA_365-510 ----------D----FNKCCR--------YWPD--------------------------- PTPN6-1_AqueP058_AA_103-225 ------------------------------------------------------------ PTPN6-3_AqueP054_AA_103-385 -------SRPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVLVESLRKQRPGM ptp-2_CeleP160_AA_256-582 PIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYKMVKYVRTYRSGL PTPN6_MbreP068_AA_224-493 --KSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRSGM PTPN6-2_AqueP053_AA_216-506 --QRGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVQGSVQMLRHHRSGM PTPN6_NvecP163_AA_0-140 --GS----GPIVVHCSAGIGRTGTFIVIDVLIHMIKEQGLDTEIDISKSIQNVRAQRSGM PTPN6-5_AqueP056_AA_221-510 --EPGQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWDAEIDIQQSIRRLREFRSGM PTPN6-4_AqueP055_AA_218-522 --SL--NPGPTVVHCSAGIGRTGTYIIIDVIIKLIESQGWDVDIDIQKSVQIARGQRSGM PTPN6-6_AqueP057_AA_218-510 --TTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRSGM PTPN6_HsapP086_AA_226-517 ------HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGM PTPN11_HsapP085_AA_229-527 --DA----GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGM csw_DmelP045_AA_317-747 --QAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGL PTPN6-3_SpurP065_AA_220-449 ------DAGSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRSGL PTPN6-1_SpurP063_AA_194-353 ------------------------------------------------------------ PTPN6-2_SpurP064_AA_365-510 ------------------------------------------------------------ PTPN6-1_AqueP058_AA_103-225 ------------------- PTPN6-3_AqueP054_AA_103-385 VQTALQYRYIYQVLEKYEK ptp-2_CeleP160_AA_256-582 VQTEQQYQFLYKALAFYLK PTPN6_MbreP068_AA_224-493 IQTAA-------------- PTPN6-2_AqueP053_AA_216-506 VQTEDQYRFLYYAIKAYIE PTPN6_NvecP163_AA_0-140 VQTEAQYEFIYKAIQHYM- PTPN6-5_AqueP056_AA_221-510 VQTDQQYKMVYQIISYYIQ PTPN6-4_AqueP055_AA_218-522 VQTEQQYKFVYRAILHYVE PTPN6-6_AqueP057_AA_218-510 VQTEQQYKFVYRSILYHIE PTPN6_HsapP086_AA_226-517 VQTEAQYKFIYVAIAQFIE PTPN11_HsapP085_AA_229-527 VQTEAQYRFIYMAVQHYIE csw_DmelP045_AA_317-747 VQTEAQYKFVYYAVQHYIQ PTPN6-3_SpurP065_AA_220-449 VQTEAQYKFVYRAVQHYIE PTPN6-1_SpurP063_AA_194-353 ------------------- PTPN6-2_SpurP064_AA_365-510 -------------------