MUSCLE (3.8) multiple sequence alignment PTPN6-1_SpurP063_AA ------------------------------------------------------------ PTPN6-2_SpurP064_AA MPRSKTVTDAASKTDTPDIPAATQAYATAESVTEFRQHFD-EFSAKIL---KKLDTVATN ptp-2_CeleP160_AA ------------------------MPRLALRQYNFYYRVN-GEKAEEL------------ PTPN6-1_AqueP058_AA --------------------------MAAESEPWFHPNLS-GFEAEEL------------ PTPN6-3_AqueP054_AA --------------------------MAAESEPWFHPNLS-GFEAEEL------------ PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA ------MLFNKCLEKLSSSLGNVVNHKLQEKQVYNNNNIN-NNNNNTLNNNNAYNNQRNF PTPN6-5_AqueP056_AA ----------------------------MAAIRCYHPNLAGGSEAEAL------------ PTPN6_MbreP068_AA -----------------------------MARKWFHPNIS-GEEAERM------------ PTPN6-2_AqueP053_AA -----------------------------MSVSAFH-HVS-RVGAEEL------------ PTPN6_HsapP086_AA ------------------------------MVRWFHRDLS-GLDAETL------------ PTPN6-4_AqueP055_AA ----------------------------MATKRWFHPNIN-GAKAEEM------------ PTPN6-6_AqueP057_AA ----------------------------MSSRRWFHMNLS-GMDAEAL------------ PTPN11_HsapP085_AA ----------------------------MTSRRWFHPNIT-GVEAENL------------ PTPN6-3_SpurP065_AA ----------------------------MASRRWFHPNIS-GMEAEQL------------ PTPN6-1_SpurP063_AA ------------------------------------------------------------ PTPN6-2_SpurP064_AA VLTIGEEIK-VVKSSISELQVAAADSASRVEALENDTIPALIKK-QKECDQSIRDAMTAM ptp-2_CeleP160_AA LKEYGEDGDFLLRYSESNP----QNFSISVRVAEDKILHIKVTKYESDMLSIFEDERTTP PTPN6-1_AqueP058_AA -LKRTVNGRFLFRPSQSNP----RDCTLSIK-TEGGVTHVRIKK-NETGYHLFPDEV--- PTPN6-3_AqueP054_AA -LKGTVNGSFLFRPSQSSP----RDCTLSIK-TEGGVTHVRIKK-NETGYHLFPDEV--- PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA EYERAIQAHYGSKGRRSEERERSGKFKASKG-RKAKVTPPTETP-EAQEPACKNCMT--- PTPN6-5_AqueP056_AA LQDKGFEGSFLIRPSINSP----GNYTLSAK-RADKTVHVRIQN-QGEFYDLYGGEK--- PTPN6_MbreP068_AA LLTQGFDGSFLVRQSRSNK----GDYALSVR-RGASVTHIKIQN-SGDFLDLYGGEK--- PTPN6-2_AqueP053_AA LLSKGTVGSFLTRRSESDP----KNFTLSVR-QRDGVTHVRIQH-DGEFYDLYGGEE--- PTPN6_HsapP086_AA LKGRGVHGSFLARPSRKNQ----GDFSLSVR-VGDQVTHIRIQN-SGDFYDLYGGEK--- PTPN6-4_AqueP055_AA LMERGTPGSFLTRPSQNNP----GDFTLSVR-REHDVTHIRIQN-QGDYYDLYGGEK--- PTPN6-6_AqueP057_AA LLSKGEDGSFLVRPSQNVQ----GDFALSVR-RTKDVTHIRIQN-SGDYYDLYGGET--- PTPN11_HsapP085_AA LLTRGVDGSFLARPSKSNP----GDFTLSVR-RNGAVTHIKIQN-TGDYYDLYGGEK--- PTPN6-3_SpurP065_AA LLNNGFDGCFLCRPSKSNP----GDFTLSVR-RNGEVTHIKIQN-TGDFFDLYGGEK--- PTPN6-1_SpurP063_AA -----------------------NQNIQEVIRKA-------------------------- PTPN6-2_SpurP064_AA EIHERKRNLLFYGIE-----KKNDENIQEVIRKA-------------------------- ptp-2_CeleP160_AA NQFGSITELAEFYMEFPEKLREKNGLFLELKKPV-------------------------- PTPN6-1_AqueP058_AA --FPNLNSFVHHYMEAP--LRLKDETLVHLLSPV-------------------------- PTPN6-3_AqueP054_AA --FPNLNSFVHHYMEAP--LRLKDETLVHLLSPV-------------------------- PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA --HDELAQIIKGVAKGADAQRNRDNRLQRRRRPLSAQPSAAASASTSTESLHRLTPSPQA PTPN6-5_AqueP056_AA --FATLSELVEYYIENPGQLKEKDGSVIHLVHPL-------------------------- PTPN6_MbreP068_AA --FANLTELIQFYTTHPGELKEVDGDVIDLRHPL-------------------------- PTPN6-2_AqueP053_AA --FASLPELLHFYTNNPGALKEKNGKVIEITKPL-------------------------- PTPN6_HsapP086_AA --FATLTELVEYYTQQQGVLQDRDGTIIHLKYPL-------------------------- PTPN6-4_AqueP055_AA --FATLAELIQYYTENPGQLKERNGTVIELGQPL-------------------------- PTPN6-6_AqueP057_AA --FATLSELIQYYTENPGQLKERNGAVIDLRYPL-------------------------- PTPN11_HsapP085_AA --FATLAELVQYYMEHHGQLKEKNGDVIELKYPL-------------------------- PTPN6-3_SpurP065_AA --FATLAELVQHYTEGRNQLKERNGQMIELKYPL-------------------------- PTPN6-1_SpurP063_AA --------------------------------------------ITSLDVSESTAQNMIF PTPN6-2_SpurP064_AA --------------------------------------------ITSLDVSESTAQNMIF ptp-2_CeleP160_AA ----------------YVPYHLEACAEEQRRTQL--------YRWWHGNLPASSANKLLQ PTPN6-1_AqueP058_AA ------------------------------------------------------------ PTPN6-3_AqueP054_AA ------------------------------------------------------------ PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA SYPATPTSWTATPPQFPAAFGGASCSNSTLSLLATMRVQLHGYTWFHGNLSGKEAEKLIL PTPN6-5_AqueP056_AA -----------------------FYEGAELT-----------DRWYHSGIDGKMAEDLLN PTPN6_MbreP068_AA -----------------------LSEDPTS------------ERWFHGQMSGPDSEAALR PTPN6-2_AqueP053_AA -----------------------PREDMSS------------ERWYHADMSGKDAELLLL PTPN6_HsapP086_AA -----------------------NCSDPTS------------ERWYHGHMSGGQAETLLQ PTPN6-4_AqueP055_AA -----------------------YSDEVT-S-----------ERWFHGGINGREAEVLIM PTPN6-6_AqueP057_AA -----------------------ICEEITS------------ERWYHGGITGKQAETLLM PTPN11_HsapP085_AA -----------------------NCADPTS------------ERWFHGHLSGKEAEKLLT PTPN6-3_SpurP065_AA -----------------------NCADPTN------------ERWFHGHITGKEAEKSLV PTPN6-1_SpurP063_AA NNVHRLPRKPNENIKTPDPIIVRFVCMS----------DRNEVLAAFER------IQRRP PTPN6-2_SpurP064_AA NNVHRLPRKPNENIKTPDPIIVRFVCMS----------DRNEVLAAFER------IQRRP ptp-2_CeleP160_AA TE-KNGTYLLRASQHIPGALVISAKTEG----------QVVHLTIYQDPSTGRFNIDGDR PTPN6-1_AqueP058_AA --------LHNNEGHLP------------------------------------------- PTPN6-3_AqueP054_AA --------LHNNEGHLP------------------------------------------- PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA ERGKNGSFLVRESQSKPGDFVLSVRTDD----------KVTHVMI-RWQ-DKKYDVGGGE PTPN6-5_AqueP056_AA SRGVTGSFLIRNSMRTPGSYVLSVRAID----------EITHIMI-NVNTSGKFYVNEKY PTPN6_MbreP068_AA ERGEHGSFLVRASQSQPGRFALSVRCGD----------AISHIII-RNN-GGSFDVGGGA PTPN6-2_AqueP053_AA AKGQDGSYIVRTSMHSPGNFVLSTRVGD----------EVSHVKI--NHKDGSFQIDNGP PTPN6_HsapP086_AA AKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPG-SPLRVTHIKV-MCE-GGRYTVGGLE PTPN6-4_AqueP055_AA SKGQDGSYLVRTSAHTPGNYVLSTRVGD----------EISHVII-RCR-DNMFDMGGGP PTPN6-6_AqueP057_AA DKGLDGSFLVRASTHSPGNYVLSARVDG----------EVAHVII-KTQ-GGEFNVGGSP PTPN11_HsapP085_AA EKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMI-RCQ-ELKYDVGGGE PTPN6-3_SpurP065_AA DKGKNGSYLVRESHSKPGDYVLSVRTED----------KVTHVMI-RCQ-DTKYDVGGGE PTPN6-1_SpurP063_AA KPAKTPDDTPRITIRTDLPAELKKARYQLEREAYNLRKTQNMSTRIRLVGVKLVLEHRPK PTPN6-2_SpurP064_AA NPAKTPDDTPRITIRTDLPAELKKARYQLEREAYNLRKTQNMSTRIRLVGVKLVLEHRPK ptp-2_CeleP160_AA TKFQSAWLLIDSYSKNPIVEKGEASRVLYLEEPLFNTFIEADLFVDRFEIIRRPINPRES PTPN6-1_AqueP058_AA -------------------------------------------------------RDGEV PTPN6-3_AqueP054_AA -------------------------------------------------------REGEV PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA S-FGTLSELIDHYKRNPMVETC--GTVVHLRQPFNATRITAAGINARVEQLVK------- PTPN6-5_AqueP056_AA C-FDTLKELIAYYLESPLTDAH--QRPVELTKPFVSTSFLPKFIPQRVSELEK--PSGFS PTPN6_MbreP068_AA S-FTDLTSLVEYYKRKPLVEAN--GNVVHLLKPFNATRLNLASIDGRFIELSK--ETEEE PTPN6-2_AqueP053_AA A-FRSLNSLIDYYKENDMVEVS--GRVVSLRQAYCTTSFLPKHIEQRVEELRQ--PNDEL PTPN6_HsapP086_AA T-FDSLTDLVEHFKKTGIEEAS--GAFVYLRQPYYATRVNAADIENRVLELNKK-QESED PTPN6-4_AqueP055_AA Q-FRSLSDLIEHYRKTPLVETG--GRVINLRSPFHSTSFLPLNIKQRVSELEK--QNQDM PTPN6-6_AqueP057_AA S-FKTLNELISHYKTHSMIETS--GRVISLKNPFNATSFMAKSIKDRVSELEK--ETGDI PTPN11_HsapP085_AA R-FDSLTDLVEHYKKNPMVETL--GTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDK PTPN6-3_SpurP065_AA Q-FETLTDLVDHYRKNPMVETT--GYVVHLKVPFNATRISASGIRNRVEVLEKETKSREN PTPN6-1_SpurP063_AA SQTLATWTSFLYVCLYECLIRYCMIGYRANTNCCGCTVKTNSSVCCINCDCFHDESCHVI PTPN6-2_SpurP064_AA SQTLATWTSFLTCTVDA----GCENGKTCESGTCTCPAGSTCDGVT-------------C ptp-2_CeleP160_AA MEKTGISEEFDRLSQEALP---AEQYLSKREGRR-------------------------P PTPN6-1_AqueP058_AA KDHLNLEQDFEEL---------PSYLYSQDKGNK-------------------------I PTPN6-3_AqueP054_AA KDHLNLEQDFEEL---------PSYLYSQDKGNK-------------------------I PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA ---GGFWEEFESLQ-QD-----SRDTFSRNEGYK-------------------------Q PTPN6-5_AqueP056_AA FGKSGFFEEFEELQKID-----SMFRKSRKIGVK-------------------------P PTPN6_MbreP068_AA FGKAGFNEEFEQLQTME-----HQHKFDRMEGAR-------------------------I PTPN6-2_AqueP053_AA FGKTGFEEEYQQLQHEG-----TQHLYTRKEAGK-------------------------P PTPN6_HsapP086_AA TAKAGFWEEFESLQKQE-----VKNLHQRLEGQR-------------------------P PTPN6-4_AqueP055_AA YGKAGFWEEFEQMQQQE-----TRHLYSRKEGVK-------------------------P PTPN6-6_AqueP057_AA MGKAGFWEEFEQLQQQE-----CRHLFSRKEGAR-------------------------V PTPN11_HsapP085_AA V-KQGFWEEFETLQQQE-----CKLLYSRKEGQR-------------------------Q PTPN6-3_SpurP065_AA SKKAGFEEEFEALQLLD-----NKHLLPRKIGDK-------------------------A PTPN6-1_SpurP063_AA QNVSDWMCKDCIICIFPF------------------------------------------ PTPN6-2_SpurP064_AA TDNADCRYEE----TCESGTCTCPAGSTCDGGDGVTCTDNAGCQDEETCESGTCTCPAGS ptp-2_CeleP160_AA VNAEKNRYKN----IVPF------------------------------------------ PTPN6-1_AqueP058_AA QNIHKNRYNA----SIPF------------------------------------------ PTPN6-3_AqueP054_AA QNIHKNRYNA----SIPF------------------------------------------ PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA ENRLKNRYRN----ILPY------------------------------------------ PTPN6-5_AqueP056_AA ENKPKNRFKN----IVPY------------------------------------------ PTPN6_MbreP068_AA ENKSKNRYKN----ILPY------------------------------------------ PTPN6-2_AqueP053_AA LNRQKNRFKN----ILPF------------------------------------------ PTPN6_HsapP086_AA ENKGKNRYKN----ILPF------------------------------------------ PTPN6-4_AqueP055_AA ENRPKNRFKN----ILPF------------------------------------------ PTPN6-6_AqueP057_AA ENKTKNRYKN----ILPF------------------------------------------ PTPN11_HsapP085_AA ENKNKNRYKN----ILPF------------------------------------------ PTPN6-3_SpurP065_AA ENKSKNRYKN----ILPY------------------------------------------ PTPN6-1_SpurP063_AA ----IDHSRVII----NDGLPG-DYINGNYIDLPKAWKNSIELQQ--------------- PTPN6-2_SpurP064_AA TCDGVDHSRVII----NDGLPG-DYINGNYIDLPKAWKNSIELQQ--------------- ptp-2_CeleP160_AA -----DHTRVILTD--RPNTPGSDYINASYV----------------------------- PTPN6-1_AqueP058_AA -----DDNVISLK---EPSVYGSTYINASPIK---------------------------- PTPN6-3_AqueP054_AA -----DDNVISLK---EPSVYGSTYINASPIK---------------------------- PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA -----DHTRVKLLDV-EHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACT PTPN6-5_AqueP056_AA -----DDTLVTLL---DPPVPDETYINASYV----------------------------- PTPN6_MbreP068_AA -----DHTRVKLRNV-PDGVIGADYINANFI----------------------------- PTPN6-2_AqueP053_AA -----DHTRVVLA---EPDSSGNTYINANYV----------------------------- PTPN6_HsapP086_AA -----DHSRVILQGR-DSNIPGSDYINANYI----------------------------- PTPN6-4_AqueP055_AA -----DHTRVILKDGYDPDVPGSDYINANYI----------------------------- PTPN6-6_AqueP057_AA -----DHTRVVLHGG-DPSIVGSDYINANYI----------------------------- PTPN11_HsapP085_AA -----DHTRVVLHDG-DPNEPVSDYINANII----------------------------- PTPN6-3_SpurP065_AA ------------------------------------------------------------ PTPN6-1_SpurP063_AA ------------------------------------------------------------ PTPN6-2_SpurP064_AA ------------------------------------------------------------ ptp-2_CeleP160_AA ------------------------------------------------------------ PTPN6-1_AqueP058_AA ------------------------------------------------------------ PTPN6-3_AqueP054_AA ------------------------------------------------------------ PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA AAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSG PTPN6-5_AqueP056_AA ------------------------------------------------------------ PTPN6_MbreP068_AA ------------------------------------------------------------ PTPN6-2_AqueP053_AA ------------------------------------------------------------ PTPN6_HsapP086_AA ------------------------------------------------------------ PTPN6-4_AqueP055_AA ------------------------------------------------------------ PTPN6-6_AqueP057_AA ------------------------------------------------------------ PTPN11_HsapP085_AA ------------------------------------------------------------ PTPN6-3_SpurP065_AA ------------------------------------------------------------ PTPN6-1_SpurP063_AA QGENVEKI-------------------------------------------------DMS PTPN6-2_SpurP064_AA QGENVEKI-------------------------------------------------DMS ptp-2_CeleP160_AA RFENSQRT------------------------------------------------KNVT PTPN6-1_AqueP058_AA TASTGGLQ---------------------------------------------------- PTPN6-3_AqueP054_AA TASTGGLQ---------------------------------------------------- PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA SGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAERERERE PTPN6-5_AqueP056_AA SGEVPGSE-------------------------------------------------N-- PTPN6_MbreP068_AA NGEAPGTD---------------------------------------------------- PTPN6-2_AqueP053_AA NGEVPGSG---------------------------------------------------- PTPN6_HsapP086_AA KNQLLGPD---------------------------------------------------- PTPN6-4_AqueP055_AA SGETPDSD-------------------------------------------------C-- PTPN6-6_AqueP057_AA SGEVPGSE---------------------------------------------------- PTPN11_HsapP085_AA ---MPEFE-----------------------------------------------TKCNN PTPN6-3_SpurP065_AA NIKVDQLD---------------------------------------------------- PTPN6-1_SpurP063_AA WEHQKRYIATQGCL----KDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANT PTPN6-2_SpurP064_AA WEHQKRYIATQGCL----KDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANT ptp-2_CeleP160_AA FACEKSFIATQGCL----ETTISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEVN PTPN6-1_AqueP058_AA ----AQYIATQGPL----DTTISDFWRLVWQEQSSIIIMLTELVEL-------------- PTPN6-3_AqueP054_AA ----AQYIATQGPL----DTTISDFWRLVWQEQSTIIIMLTELVELGESMCTRYWPTVEI PTPN6_NvecP163_AA ------------------------------------------------------------ csw_DmelP045_AA REMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGR PTPN6-5_AqueP056_AA -----CYIAAQGCL----QSTVGDFWHMIWQENSRVIVMITKEMERNREKCYRYWPSTID PTPN6_MbreP068_AA ----KAYIASQGTM----PDTVADFWQMIVEQNCRLVVMATNPVEKGKHKCTPYWPSSER PTPN6-2_AqueP053_AA ----NYYIATQGCL----PGTINDFWSMVWQEDSKIIVMITNEIERGKNKCARYWPSKGE PTPN6_HsapP086_AA -ENAKTYIASQGCL----EATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGM PTPN6-4_AqueP055_AA -----EYIATQGCL----PATVNDFWRMVWQEGSLVIVMITNEVERGRNKCSRYWPSPES PTPN6-6_AqueP057_AA ----KHYIATQGCL----PTTINDFWKMIWQESSQIIVMTTNEVERGRNKCARYWPGINE PTPN11_HsapP085_AA SKPKKSYIATQGCL----QNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYA PTPN6-3_SpurP065_AA ----------SNCV--------------------------------AINKCCRYWPDANT PTPN6-1_SpurP063_AA KKD-TGVITVTHISE-QSM---------------------------------ADYDLREF PTPN6-2_SpurP064_AA KKD-TGVITVTHISE-QSM---------------------------------ADYDLREF ptp-2_CeleP160_AA KPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTNRIAKGLVPEAELNGDGISYILRTL PTPN6-1_AqueP058_AA ------------------------------------------------------------ PTPN6-3_AqueP054_AA PEVLHGKILISSLEE-TTL---------------------------------DYYTMRHF PTPN6_NvecP163_AA ------VYHIKHIQE-TEL---------------------------------PHYILREF csw_DmelP045_AA SEQ-FGHARIQCVSE-NST---------------------------------SDYTLREF PTPN6-5_AqueP056_AA DEMIYGEVNVKLVAE-KGQ---------------------------------FQYILRQF PTPN6_MbreP068_AA RPARFGNYVVELLTE-DNF---------------------------------DAYTVRRM PTPN6-2_AqueP053_AA TTL-YGNIQVINIDEIQGR---------------------------------L-YVFRKL PTPN6_HsapP086_AA QRA-YGPYSVTNCGE-HDT---------------------------------TEYKLRTL PTPN6-4_AqueP055_AA PEETYGLIHVTSLEEDTAN---------------------------------SHYILRHF PTPN6-6_AqueP057_AA TGE-YGDISVQNATE-CIN---------------------------------PHYIYREF PTPN11_HsapP085_AA LKE-YGVMRVRNVKE-SAA---------------------------------HDYTLREL PTPN6-3_SpurP065_AA KKD-TGVITVTHISE-QSM---------------------------------ADYDLREF PTPN6-1_SpurP063_AA SMSHK-----------DFNKCCRY--------WPDANTKKDTGVI--------------- PTPN6-2_SpurP064_AA SMSHK-----------DFNKCCRY--------WPDANTKKDTGVI--------------- ptp-2_CeleP160_AA VMKKG--------------KDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFN PTPN6-1_AqueP058_AA ------------------------------------------------------------ PTPN6-3_AqueP054_AA LLSH------------EEKGEERNVFHFHFRDWPVGSVPRSTGAFLDYWKEINAKTKETS PTPN6_NvecP163_AA EI-WI-----------DSNPIPRSVYQFHYTGWPDHGVPKDPSPVLSILQEVDIKQKAVP csw_DmelP045_AA LVSWR-----------DQP--ARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLA PTPN6-5_AqueP056_AA RVCKG-----------D--ETERSVHQYHYKSWPDHGVPQDPGLFLGFIEDVNRKIKDFE PTPN6_MbreP068_AA SVAVG-----------E--GDPREIYQYHYTSWPDHGVPPERE-FLQLIMKIRQHRDRLR PTPN6-2_AqueP053_AA HIEHV-----------SKKGRGHYVVQYQFKVWPDHGVPQDPSHMLDLMDDVNRKALEIQ PTPN6_HsapP086_AA QVSPL-----------DNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLP PTPN6-4_AqueP055_AA LVEKRAPDAPEEDGGDEGAYESRHIFQFHFKAWPDHGVPQDPGVVLAFMQDVNMKVQQLR PTPN6-6_AqueP057_AA IIHRI-----------EDPSNQREVFHYHFKAWPDHGVPQDPGTVLSFLQDINSKQDELV PTPN11_HsapP085_AA KLSKVGQAL-------LQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIM PTPN6-3_SpurP065_AA SMSHK-----------DFPEESRPMFHFHFKSWPDHGVPSDPSRVLNFLQDVNKKQETFP PTPN6-1_SpurP063_AA ------------TVTHISE----------------------------------------- PTPN6-2_SpurP064_AA ------------TVTHISE----------------------------------------- ptp-2_CeleP160_AA AQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYKMVKYVRTYRS PTPN6-1_AqueP058_AA ------------------------------------------------------------ PTPN6-3_AqueP054_AA ----S-----RPMIVHCNDGIGRTGAFIAIDSLLRQKEVKGNNVLGEMKVLVESLRKQRP PTPN6_NvecP163_AA ----GS----GPIVVHCSAGIGRTGTFIVIDVLIHMIKEQGLDTEIDISKSIQNVRAQRS csw_DmelP045_AA ----QAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRS PTPN6-5_AqueP056_AA ----EPGQTSGPIVVHCSAGIGRTGTYIITDILVKLIEYQGWDAEIDIQQSIRRLREFRS PTPN6_MbreP068_AA ----KSIPGLGPTLVHCSAGIGRTGTFLVIDIVLDLIRHYGIDCDIDIQSIIHKLRGQRS PTPN6-2_AqueP053_AA ----QRGEHFGPMIVHCSAGVGRTGTYIVVDIITKMMEYNKFEYEIDVQGSVQMLRHHRS PTPN6_HsapP086_AA ----HA----GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRS PTPN6-4_AqueP055_AA ----SL--NPGPTVVHCSAGIGRTGTYIIIDVIIKLIESQGWDVDIDIQKSVQIARGQRS PTPN6-6_AqueP057_AA ----TTGNEPGPLIVHCSAGIGRTGTFIVIDILLNVMMQQGFEADVDIQRAIQLVRAQRS PTPN11_HsapP085_AA ----DA----GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRS PTPN6-3_SpurP065_AA ----DA----GSIIVHCSAGIGRTGTFIVIDIILNLIKQHGLDCEIDIYNTIRLVRQQRS PTPN6-1_SpurP063_AA ---QSMADYDLREFSMSHKDF--------------------------------------- PTPN6-2_SpurP064_AA ---QSMADYDLREFSMSHKDFQQQQLR----------------IIIGNITIINIIIIAMF ptp-2_CeleP160_AA GLVQTEQQYQFLYKALAFYLKNNNPYPVKSFIDGDTDAFDFPRRLRPTPNASRPSSARQV PTPN6-1_AqueP058_AA ------------------------------------------------------------ PTPN6-3_AqueP054_AA GMVQTALQYRYIYQVLEKYEKNDRNGRPPMKIVESLRKVEDSESGKKVSPLLRNIYRRMS PTPN6_NvecP163_AA GMVQTEAQYEFIYKAIQHYMSTEMARIRGSKEGVEG-------AVYGNLPKLPTANPDAP csw_DmelP045_AA GLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVG------REYTNIKYTGEIGNDSQ PTPN6-5_AqueP056_AA GMVQTDQQYKMVYQIISYYIQIREKLLSAASSE----------NLYDQVDAPPLQPPQRT PTPN6_MbreP068_AA GMIQTAAQYRFIYKAVMDYIQSHKSRP--------------------------------- PTPN6-2_AqueP053_AA GMVQTEDQYRFLYYAIKAYIERRQSLNE---------------ALYVNVTTK-------- PTPN6_HsapP086_AA GMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQE------SEYGNITYPPAMKNAHA PTPN6-4_AqueP055_AA GMVQTEQQYKFVYRAILHYVEA-STQLKQAFSQSSTGTVQTTESLYGNAPEVLQLK---R PTPN6-6_AqueP057_AA GMVQTEQQYKFVYRSILYHIETQRQLSESNNGVTD--------HVYGNIPASLAGGAK-- PTPN11_HsapP085_AA GMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKG------HEYTNIKYSLADQTSGD PTPN6-3_SpurP065_AA GLVQTEAQYKFVYRAVQHYIETLSQRVAAEQNTLKTG------REYINTKRAHYEVQQHH PTPN6-1_SpurP063_AA ------------------------------------------------------------ PTPN6-2_SpurP064_AA LIHYPTY----------------------------------------------------- ptp-2_CeleP160_AA TSSRPSS----------------------------------------------------- PTPN6-1_AqueP058_AA ------------------------------------------------------------ PTPN6-3_AqueP054_AA TPEKLKK----------------------------------------------------- PTPN6_NvecP163_AA PPLPLTY----------------------------------------------------- csw_DmelP045_AA RSPLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLPVVNCNN PTPN6-5_AqueP056_AA MSTKV------------------------------------------------------- PTPN6_MbreP068_AA ------------------------------------------------------------ PTPN6-2_AqueP053_AA ------------------------------------------------------------ PTPN6_HsapP086_AA KASRTSS----------------------------------------------------- PTPN6-4_AqueP055_AA HPEMPPE----------------------------------------------------- PTPN6-6_AqueP057_AA ------------------------------------------------------------ PTPN11_HsapP085_AA QSPLPPC----------------------------------------------------- PTPN6-3_SpurP065_AA TPGSTPI----------------------------------------------------- PTPN6-1_SpurP063_AA ------------------------------------------------------------ PTPN6-2_SpurP064_AA ------------------------------------------------------------ ptp-2_CeleP160_AA --------------------------------------------------SASSRTSHSR PTPN6-1_AqueP058_AA ------------------------------------------------------------ PTPN6-3_AqueP054_AA ------------------------------------------------------------ PTPN6_NvecP163_AA ---------------------------------------------GVGSMSKGPPPRPPG csw_DmelP045_AA NNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALLGGIGLGLGGNMRKSNFYSDSLKQQQQ PTPN6-5_AqueP056_AA ------------------------------------------------------------ PTPN6_MbreP068_AA ------------------------------------------------------------ PTPN6-2_AqueP053_AA ------------------------------------------------------------ PTPN6_HsapP086_AA --------------------------KSLESSAGTVAASPVRRGGQRGLPVPGPPVLSPD PTPN6-4_AqueP055_AA ------------------------------------------------------------ PTPN6-6_AqueP057_AA ------------------------------------------------------------ PTPN11_HsapP085_AA ------------------------------------------------------------ PTPN6-3_SpurP065_AA ----------------------------------------LSPAILNEDKNVYQNVGPIN PTPN6-1_SpurP063_AA --------------------------------------------- PTPN6-2_SpurP064_AA --------------------------------------------- ptp-2_CeleP160_AA PRTGPQAEPIFERSTSSTSSSSTLLKSTKK--------------- PTPN6-1_AqueP058_AA --------------------------------------------- PTPN6-3_AqueP054_AA --------------------------------------------- PTPN6_NvecP163_AA DHIGPQPPGTTPGEKPPPLAPRKVR-------------------- csw_DmelP045_AA REEQAPAGAGKMQQPAPPLRPRPGILKLLTSPVIFQQNSKTFPKT PTPN6-5_AqueP056_AA ---APPKPPRMPKKQN----------------------------- PTPN6_MbreP068_AA --------------------------------------------- PTPN6-2_AqueP053_AA --------------------------------------------- PTPN6_HsapP086_AA LHQLPVLAPLHPAADTRRMCMRTCTLRTRGRRK------------ PTPN6-4_AqueP055_AA ---IPEKPPEIPRRSKPSY-------------------------- PTPN6-6_AqueP057_AA --------------------------------------------- PTPN11_HsapP085_AA ---TPTPPCAEMREDSARVYENVGLMQQQKSFR------------ PTPN6-3_SpurP065_AA NMSTPIPPRARPAQPPVPKSNNIK---------------------