MUSCLE (3.8) multiple sequence alignment Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA ------------------------------------------------------------ PTPRN_HsapP105_AA ------------------------------------------------------------ PTPRN2_HsapP106_AA ------------------------------------------------------------ IA-2_DmelP051_AA MPAVGTSCGVPIIMARNVQQRQQHPCTTTEEPKHQRARGTAGHQESATGECQQFWSKQRP PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA ------------------------------------------------------------ PTPRN_HsapP105_AA ------------------------------------------------------------ PTPRN2_HsapP106_AA ------------------------------------------------------------ IA-2_DmelP051_AA PFDQQQQQEDQDPEQDPQQHPSTPQESVHHHRSPRQHELLHHQRKVPPTLPARGRHLISE PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA --------------MRFFH----------------SIIVLLFSIST------------GS PTPRN_HsapP105_AA --MRRPRRPGGLGGSGGLR----------------LLLCLLLLSSR---------PGGCS PTPRN2_HsapP106_AA ------------MGPPLPL----------------LLLLLLLLPPRVLPAAPSSVPRGRQ IA-2_DmelP051_AA GARRREVRGCGAGGGGLLCCSLDALSRPAKLLQFGVLLLILLLATH---------GDLAQ PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA AFLLYGCNLSENLC-DNDESCYPDGVFGQCYSSESGSPEPTVLDNLDDTQLELLKLELTR PTPRN_HsapP105_AA AVSAHGCLFDRRLC-SHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVLQRLQG---VLRQ PTPRN2_HsapP106_AA LPGRLGCLLEEGLC-GASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRV---ALQK IA-2_DmelP051_AA AEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEE PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ---------------------------MLVRQRPADERQRLADESITEEDADEIVALLVS Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA LAAKDKDWGDEETQCVLAYFKMSMFYQLQYDPDFC----------------------QVR PTPRN_HsapP105_AA LMSQGLSWHDDLTQY------VISQEMERIPR--LRPPEPRPRDRSGLAP-------KRP PTPRN2_HsapP106_AA LSGTGFTWQDDYTQY------VMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSRE IA-2_DmelP051_AA LQGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPP PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA LL---------------------------------------------------------- Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA KPANVWALIQLIDTGLTEDPTILDEDVNPENVT--------------------------- PTPRN_HsapP105_AA GPAGELLLQDIPTGSA---PAAQHRLPQPPVGK--------------------------- PTPRN2_HsapP106_AA GGAA-------LANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTY IA-2_DmelP051_AA EPEAELDYYEQPAGPAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKM PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA -----------------------------MSDDTSASVWNDGGPPEIQEQ-------KPK ida-1_CeleP113_AA ----------DEDMAQIIEQLKEPSLPTEEDIEEALNAQNEDVDDEILDQYVQAVVNNEN PTPRN_HsapP105_AA -GGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVS PTPRN2_HsapP106_AA VAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPP IA-2_DmelP051_AA DGHGQSTQLDAPS---IMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAAS PTPRN_NvecP082_AA --------------------MKDNSYTQESGKQVAKRLNEDGSVKDEVSKRMNVRIISAD PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA -------------------ELPPSIFSDIKVKDKEITVHVNDSSRHFTPKAIAIKIVDGS Y41D4A.5_CeleP217_AA SPPPPLPTSNP-------------------------------VVKDTPNVV--------- ida-1_CeleP113_AA PDFSELSDGQLNILIGRLVDLKKNVE----------NEEAQLLTGDGEQEM--------- PTPRN_HsapP105_AA EGSPGMVSVGP------LPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSG PTPRN2_HsapP106_AA AP-PGEGSLEPQYLLRAPSRMPRPLLAPAA------PQKWPSPLGDSEDPS-----STGD IA-2_DmelP051_AA EPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEV-----NESS PTPRN_NvecP082_AA GEVPEKHDSQA-----------------------------------EPKKV--------- PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA VVVVQQWSHSREVLGSKPSRCPRALLFLSHEALRIFGDSGYGQHNDHP------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA -----------------AVPLDDLEERGEQAILKKDIEQVGE------------------ PTPRN_HsapP105_AA LLYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKPASP---------- PTPRN2_HsapP106_AA GARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQ IA-2_DmelP051_AA ELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEV PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA ----------------------------INQGLDNTEHKIVKGRKDQVVTRVDANRVYLK PTPRN_HsapP105_AA AVQPDAALQR------------------LAAVLAGYGVELRQLTPEQLSTLLTLLQLLPK PTPRN2_HsapP106_AA ADGPKATLRG------------------DSFPDDGVQDDDDRLYQEVHRLSATLGGLLQD IA-2_DmelP051_AA DATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKS PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA VHLKNEDQLMPLIEFLQNTIAIPNN----------------------------------- PTPRN_HsapP105_AA GAGRNPGGVVNVGADIKKTMEGPVEGRDTAELP----------------ARTSPMPGHPT PTPRN2_HsapP106_AA HGSRLLPGALPFARPLDMERKKSEHPESSLSSE----------------EETA---GVEN IA-2_DmelP051_AA QRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLLGPPS PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA ------------------------------------------------------------ PTPRN_HsapP105_AA ASPTSSEVQQVPSPVSSEPPKAARPPVTPVL-------LEKKSPLGQSQPTVAGQPSARP PTPRN2_HsapP106_AA VKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPS IA-2_DmelP051_AA LGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHS-AEDHAPHT PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA ------------------------------LYFDDFQFENGQLSMRISRFEGAKPKADKR PTPRN_HsapP105_AA AAEEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLS PTPRN2_HsapP106_AA EEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVT IA-2_DmelP051_AA VDTEYVHVFVKNPIDSWNDGQRIMKELEQILHM-QGYFSYLTVQQHEVSFRVNSNNPERK PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA ------------------------------------------------------------ ida-1_CeleP113_AA IDSVEGVASAVYKR-RKDIARLSGADVRETGIG--SGEDGSLPVESSE----RDWLLMPV PTPRN_HsapP105_AA LADVTQQA----GLVKSELEAQTGLQILQTGVGQREEAAAVLPQ-TAH----STSPMRSV PTPRN2_HsapP106_AA TEDVEKATVDN----KDKLEETSGLKILQTGVGSKSKLKFLPP--QAE----QEDSTKFI IA-2_DmelP051_AA TAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTH PTPRN_NvecP082_AA ----------------------------------------------------TNVQPKYF PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------VKVVSAG---------------------GSDNAALV Y41D4A.5_CeleP217_AA ---------PTGDLI----------QFESEEERAATTVPNGNPVIFEKNPAMDGLLREFL ida-1_CeleP113_AA LFVCAFTVTALGLVAAVQIARS--RRHYKDNIQQIAEQLDG-----KNSFAYQDLCRQR- PTPRN_HsapP105_AA LLTLVALAGVAGLLVALAVALCV-RQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHM PTPRN2_HsapP106_AA ALTLVSLACILGVLLASGLIYCL-RHSSQHRLKEKLSGLGGDPGA-DATAAYQELCRQRM IA-2_DmelP051_AA IMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAE-TCSKDYQELCRARM PTPRN_NvecP082_AA LVTVTVVGCVTGVILAAVAIYLIMKRYNETKKFKPVTLPGQ-----EAAADYQELCRQLR PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ILTVVLVACVVGILIAIVTVYCLKKRSNEKAKVTELKQSEGENGN-EASADYQDLCRQRM Y41D4A.5_CeleP217_AA KEEEAYTPQD-------------------------------------------------- ida-1_CeleP113_AA ----------------------------------ADGGRASKSSSTSSWCEETAVPTIDI PTPRN_HsapP105_AA ATKSLFNRAE-------GPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDI PTPRN2_HsapP106_AA ATRPPD--RP-------EGPHTSRISSVSSQFSDGPIPSPSARSSASSWSEEPVQSNMDI IA-2_DmelP051_AA AGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDI PTPRN_NvecP082_AA AN---------------QGWDSAPVKSGSGHMEKEKGLLGSAKPPKYTWSEEPVVPNMDI PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ATKSD------------KPEPLTRVSSVAA--SEGAQPSPSSRSSTSSWSEEPVQSNMDI Y41D4A.5_CeleP217_AA ---YLRRFYQIRVEQEKLRMEAEYRSEC-----------AVAPQHYARNRYRDILPYDKN ida-1_CeleP113_AA STGHVVLNFLQEYLSEPTKIEAQWNGIKDYRNEERTK--TKAEKFASQNR--TILPFDDN PTPRN_HsapP105_AA STGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHA PTPRN2_HsapP106_AA STGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHS IA-2_DmelP051_AA STGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHS PTPRN_NvecP082_AA STGHVVLSYMEDHLSNKNRLNKEWEALCNYEAEPSVADLGKQDKNVRKNRYSDVLPYDHN PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA STGHVVLSYMEDHLNNKDRMSKEWEALCSYEADPCTQDAGKAPENANKNRVKNAIPYDHT Y41D4A.5_CeleP217_AA RVEIQ-KDSENPEGYMNAS-LIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVIL ida-1_CeleP113_AA IVDIDGKTAENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNL PTPRN_HsapP105_AA RIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVML PTPRN2_HsapP106_AA RVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVML IA-2_DmelP051_AA RVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVAL PTPRN_NvecP082_AA RVSLRETANATGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGVVVIVNL PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA RVKLTEETSANKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNL Y41D4A.5_CeleP217_AA CKLVELNKIKCERYWPEQVGESELFGDYEITLEEEKLFDDDEYLMRCLKMENQTTGECRK ida-1_CeleP113_AA STPEE--CKQEKNYWPDT--GSEVHGAFEIHLVSEHIWSDD-YLVRSFYLKNLQNSQTRT PTPRN_HsapP105_AA TPLVEDGVKQCDRYWPDE--GASLYHVYEVNLVSEHIWCED-FLVRSFYLKNVQTQETRT PTPRN2_HsapP106_AA TPLAENGVRQCYHYWPDE--GSNLYHIYEVNLVSEHIWCED-FLVRSFYLKNLQTNETRT IA-2_DmelP051_AA CRLQENGEVACARYWPEE--GAEVYHIYEVHLVSEHIWCDD-YLVRSFYLKNLRTSETRT PTPRN_NvecP082_AA TRLSDLGLPQCHRYWPED--GHETYHIYEVHLVSEHIWCDD-YLVRSFYLKNLQTSETRT PTPRN-a_SpurP076_AA ------------------------------------------------------TQETRT PTPRN-b_SpurP077_AA THMSETDINRC-RYWPDE--GSALYHFYEVHLVSEHVWCED-YLVRSFYLKNLETQETRT . : *. Y41D4A.5_CeleP217_AA VHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAI ida-1_CeleP113_AA ITQFHYLSWQKESTPTSAKSIL---EFRRKVNKSYRG-RSSAVLVHSWDGSGRTGVYCAV PTPRN_HsapP105_AA LTQFHFLSWPAEGTPASTRPLL---DFRRKVNKCYRG-RSCPIIVHCSDGAGRTGTYILI PTPRN2_HsapP106_AA VTQFHFLSWYDRGVPSSSRSLL---DFRRKVNKCYRG-RSCPIIVHCSDGAGRSGTYVLI IA-2_DmelP051_AA VTQFHFLSWPHMGVPAQAKALL---DFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILL PTPRN_NvecP082_AA VTQFHFLSWPDLNVPTTPKPLL---EFRRKVNKCFRG-RSCPIVVHCSGGVGRTGCYILI PTPRN-a_SpurP076_AA VTQFHFLTWPETGCPPSPKSLL---EFR-------------------------------- PTPRN-b_SpurP077_AA VTQFHFLTWPETGCPPSPKSLL---EFRRKVNKSFRG-RACPIVVHCSDGVGRTGTYCLL : *:*: * . *. . :* :: Y41D4A.5_CeleP217_AA NFIREQMKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLGIIEEPK ida-1_CeleP113_AA DVLCARL-LRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLLKSIATK- PTPRN_HsapP105_AA DMVLNRM-AKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ-- PTPRN2_HsapP106_AA DMVLNKM-AKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ-- IA-2_DmelP051_AA DLVLERM-NKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANT PTPRN_NvecP082_AA DLVLNKM-MRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNAILQALAK-- PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA DLVLTRM-LKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAILKALPQ-- Y41D4A.5_CeleP217_AA LDLAPPVATADLPVGSSGSVRLIAPPTPTTGPSTDQTATIANYNQLHHHQSSSNHMDEDT ida-1_CeleP113_AA ------------------------------------------------------------ PTPRN_HsapP105_AA ------------------------------------------------------------ PTPRN2_HsapP106_AA ------------------------------------------------------------ IA-2_DmelP051_AA SGEKRELDKDPVVGGGSSSTTTKEPLKEDKAQEAAEEEAPTSSSKAAAAAKKEKEKDKDK PTPRN_NvecP082_AA ------------------------------------------------------------ PTPRN-a_SpurP076_AA ------------------------------------------------------------ PTPRN-b_SpurP077_AA ------------------------------------------------------------ Y41D4A.5_CeleP217_AA STEEAASVPDFPEEPPAPMGPEDLGSSAAF ida-1_CeleP113_AA ------------------------------ PTPRN_HsapP105_AA ------------------------------ PTPRN2_HsapP106_AA ------------------------------ IA-2_DmelP051_AA EEKQAKDQAKVAEPRTPAKSAKQAKK---- PTPRN_NvecP082_AA ------------------------------ PTPRN-a_SpurP076_AA ------------------------------ PTPRN-b_SpurP077_AA ------------------------------