MUSCLE (3.8) multiple sequence alignment PHO8_ScerP022_AA ---------------------------------------------------MMTHTLPSE alp_DdisP001_AA -----------------------------------------------------MEQAPNS CG5361_DmelP010_AA -----------------------------------------MVTTQQTKEICEIIRLKST CG16771_DmelP004_AA MEKRSGTPINSQKFRKLSDVDMTEVQLNNLDDSSAKETVEIGSFQGNDQSNPVQHTKWFR Aph-4_DmelP001_AA ------------------------------------------------------------ ALP_NvecP001_AA ----------------------------------------------------------MI ALPL_HsapP002_AA ----------------------------------------------------------MI ALPI_HsapP001_AA ----------------------------------------------------------MQ ALPP_HsapP003_AA -------------------------------------------MPRIPASPLSCCPPDML ALPPL2_HsapP004_AA ----------------------------------------------------------MQ ALP-d_SpurP004_AA ----------------------------------------------------MILLDSTE ALP-c_SpurP003_AA ----------------------------------------------------------MV ALP-a_SpurP001_AA ------------------------------------------------------------ ALP-b_SpurP002_AA ------------------------------------------------------------ CG10827_DmelP003_AA ----------------------------------------------------------MF CG5150_DmelP009_AA --------------------------------------------------------MLSL CG5656_DmelP011_AA ---------------------------------------------------------MRA CG8147_DmelP013_AA ------------------------------------------------------------ CG10592_DmelP002_AA ----------------------------------------------------------MV CG1809_DmelP005_AA ----------------------------------------------------------MA CG8105_DmelP012_AA ----------------------------------------------------------ML CG3292_DmelP008_AA -----------------------------------------------------------M CG3264_DmelP006_AA -------------------------------------------------------MGSSQ CG3290_DmelP007_AA -------------------------------------------------------MHISQ PHO8_ScerP022_AA QTRLVPGSDSSSRPKKRRISKRSKI----------------------------------- alp_DdisP001_AA SSIRESGIGGGG--------GGGGGGNDKDEMD---GSTAIPMEPMTSSSGVSSGGGGKV CG5361_DmelP010_AA QVFLVAGTCLIT----VMVTLLCIG-------------------FMTRYEVENDVANVAD CG16771_DmelP004_AA SRLFLISVVFSA----LLITAMCIG-------------------FVVHYGMSGDVGDMET Aph-4_DmelP001_AA MHCLVILGFLLG----SLVAFSWAG--------------VTTQPPPLIRTLSAGGDIGPQ ALP_NvecP001_AA RVDTLLVFAFCL----VVLTALCSG----------------------------------- ALPL_HsapP002_AA SPFLVL---AIG----TCLTNSL------------------------------------- ALPI_HsapP001_AA GPWVLL---LLG----LRLQLSLGV----------------------------------- ALPP_HsapP003_AA GPCMLLLLLLLG----LRLQLSLGI----------------------------------- ALPPL2_HsapP004_AA GPWVLL---LLG----LRLQLSLGI----------------------------------- ALP-d_SpurP004_AA DRFGEVGRNKGNRMKILLIIAVCMY----------------------------------- ALP-c_SpurP003_AA QRFIYL---TLN----SMVDCSNRS----------------------------------- ALP-a_SpurP001_AA MDFVIMEKATAF----ILLLLSLFQ----------------------------------- ALP-b_SpurP002_AA MEFTF----SVG----ILLLASL------------------------------------- CG10827_DmelP003_AA RLLNALLIAIVLVAHPAWSAPECGR---------------TPEECREHRMHPDMPEPERH CG5150_DmelP009_AA KFWIRLGLLTVVWG--AAVPGRAPV-----------------------DEERMHPHLPTS CG5656_DmelP011_AA LRFFAALALQLT----ACSS-------------------------------QYKYGPEQS CG8147_DmelP013_AA MRLQLFFFLGLS----VLVSGGESSHDAERRMHPVFSLMGTGSNPIGGGRYKRAMPQIVF CG10592_DmelP002_AA KSCLILCFFAL-----LVIQARSDL--------------------ADDQEHAQHPRLQSS CG1809_DmelP005_AA RRFILLLVLA------VCLSGSASG----------------------QRDHPRGRSFDAE CG8105_DmelP012_AA LQLRRLAILFLLHALIPILALSVPM----------------------------------- CG3292_DmelP008_AA KTFVAISLVLC-----TLVATSLAASIDMPEIHNQFQLVGGSVSTAKTREGNLIDPNAMA CG3264_DmelP006_AA RQLVLPILLLLA----LAGTALCGV-----------QEVHNVLELTGQAANKLKFSTDVA CG3290_DmelP007_AA RRCLYPIFLFLL----AFVGTALGR----------VQEVHNVLELTGQKASKLRFSTDVA PHO8_ScerP022_AA ----IVSTVVCIG----------LLLVLVQLAFPSSFALR----SAS--HKKK--NVIFF alp_DdisP001_AA VSHFLLEEDFDSKKRFTSTHKRIFYILTSLAILVTVVLLIVFLLPRGWEGPKKKTNIIMM CG5361_DmelP010_AA VDYWKDKVATSQK----------IWYDKGIDELNEALRPQ-----DL--TYPK--NVRIF CG16771_DmelP004_AA VSYWPVDLPKEQK----------EWYDQGIDELQKAVSRQ----FNR--RRAK--NVILF Aph-4_DmelP001_AA FDVGKTKEPEDAE----------FWHNVGLRQLEKTIKQAQRVKEDSYQKKAR--NIIIF ALP_NvecP001_AA ----DVPASQSNN----------QWFKDGVSTVKKHLLQR----PNT--KPAK--NLIIF ALPL_HsapP002_AA ----VPEKEKDPK----------YWRDQAQETLKYALELQK---LNT--NVAK--NVIMF ALPI_HsapP001_AA ----IPAEEENPA----------FWNRQAAEALDAAKKLQ----PIQ--KVAK--NLILF ALPP_HsapP003_AA ----IPVEEENPD----------FWNREAAEALGAAKKLQ----PAQ--TAAK--NLIIF ALPPL2_HsapP004_AA ----IPVEEENPD----------FWNRQAAEALGAAKKLQ----PAQ--TAAK--NLIIF ALP-d_SpurP004_AA ----VPVQGQSPD----------FWNSQARSSIEQALGLE----VNT--KPAK--NVIVF ALP-c_SpurP003_AA ----PSLTSSDAE----------FWNQEAQDSLKEAIRLTE---RNV--NTAK--NIVLF ALP-a_SpurP001_AA ----VLISAQEAP----------YWNLKGRAAVEEALLRQR---LNV--NIAK--NIIFF ALP-b_SpurP002_AA ----SLVNGQDAA----------FWNNQARDSIQKALERE----LNI--GEAK--NIIFF CG10827_DmelP003_AA GKAFRVVDGEDTNA---------YWRQQGVQFVQQKLASE----PNK--RQAK--NVILF CG5150_DmelP009_AA PRLRTISGEETQE----------FWHSASKKLIREKLEFV----RNT--KKAK--NIILF CG5656_DmelP011_AA WDLDSISELKSKE----------FWFHDAQRTLYNKLSTP----PNQ--YRAK--NVIFF CG8147_DmelP013_AA DA--VRSEERYAE----------YWQGLAAQTLDQQLESKLR--LNT--QLAR--NVMLF CG10592_DmelP002_AA RDFEALDEELDTR----------FWHDKAQSILADKLAGHKK--LNE--NRAK--NVILF CG1809_DmelP005_AA SHPIKYAEEQQTQ----------YWVDKAQAKLLSKLAEQES--ATT--NKAK--NVILF CG8105_DmelP012_AA VEQVQPADELLSS----------HWLRQAQSQLRERLARTKDSIADV--RQAK--NVVML CG3292_DmelP008_AA KGKPGPEEEKNAQ----------FWYDLAYEEIAKRLEQPQ---LDK--RKAK--NVILF CG3264_DmelP006_AA TEKYTPPEEMDPQ----------YWYNIADEEITKRLQLPQ---PNS--QKAK--NIIMF CG3290_DmelP007_AA TGKYTPPEEMDPQ----------FWYKLADEEIAKRLQLPQ---PNS--DRAK--NVIMF . . *: .: PHO8_ScerP022_AA VTDGMGPASLSMARSFNQ--HVNDLPIDDILTLDEH-FIGSSRTRSSDSLVTDSAAGATA alp_DdisP001_AA IGDGMGPAALTMARVCFH--TKGESTSQAHLHLDPY-IVGTVKTYSSNSVVTDSAAAATA CG5361_DmelP010_AA VIQGIDGRDWAAFRFPTSDASRGN----TNFIWDRFPHLARLKNSCSQQFPCQVASVSRA CG16771_DmelP004_AA VGDGMGPNTVTAARIL-------GVKEEGLLRWEQFPDMGLLKTYCADKQVPDSFSTATA Aph-4_DmelP001_AA IGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFPNTGMAKTYNVDKQVPDSAGTATA ALP_NvecP001_AA VGDGCDINTNTAGRILKGQ-LKGQVGEKGWLSYEEFPYTGLSKTYTTNRQGSDSAGTANA ALPL_HsapP002_AA LGDGMGVSTVTAARILKGQ-LHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATA ALPI_HsapP001_AA LGDGLGVPTVTATRILKGQ-KNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATA ALPP_HsapP003_AA LGDGMGVSTVTAARILKGQ-KKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA ALPPL2_HsapP004_AA LGDGMGVSTVTAARILKGQ-KKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATA ALP-d_SpurP004_AA VGDGMDVSTVVSSRIRQGQ-QAGVEGVSNVLAWDAFPHGGLVKTYSTDAQAADSASTSTA ALP-c_SpurP003_AA LGDGMSIETLTAARILKGQ-LAGGLGEDAKLAVEDFPHFGLAKTYSTNKQVPDSAATATA ALP-a_SpurP001_AA LGDGLDVTTTTAARIRKGQ-LAGGMGEEASLHFEHFPHVGLVKTYNTDRQVPDSAGTATA ALP-b_SpurP002_AA LGDGMSVPTVTAARIRQGQ-LKGETGEENILAWETFPHVGLIKTYNTDAQVPDSAGTATA CG10827_DmelP003_AA LGDGMGVTTTSAARNLLG-------GEEKSLSFENFPFTGLSKTYSVDKIVPDSACTATA CG5150_DmelP009_AA LGDGMGLATLAAARSYIG-------GEELKLSFEEFPFTGLSKTYSVDKIVPDSACTSTS CG5656_DmelP011_AA LGDGMSVPTVTAGRIFDGQ-LRGVVGERNRLEFEKFNYVGLSKTYCVNKQVADSACTASA CG8147_DmelP013_AA IGDGMSIPTITAGRVYLG-------GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATA CG10592_DmelP002_AA LGDGMSVHTIAATRAFMG-------DSNKQVFFEKFPYLGLSKTYAVNERTPDSANTATA CG1809_DmelP005_AA LGDGMSVHTVTATRNLLG-------DSAEQVYFEGFPYTGLSKTYCVNRQVADSACTATA CG8105_DmelP012_AA LGDGLSITTLTAARILKGQ-RRGGRGEDAQLAVEQFPFSGLSKTYCIDEQTPDSACTATA CG3292_DmelP008_AA LGDGMSLSTVAAARIHKGQ-LKGNTGEEDSLSFEKFPYTGLSRTYCSNAQVPDSACTATA CG3264_DmelP006_AA LGDGMPLSTVAAARILKGQ-RQGNTGEESSLSFERFPYTGLSRTYCSNAQVPDSACTATA CG3290_DmelP007_AA LGDGMPISTVTAARILKGQ-RQGNTGEESSLSFEKFPYSGLSRTYCANAQVPDSACTATA : :* * . : . . .. : : : : PHO8_ScerP022_AA FACALKSYNGAIGVDPH------------HRPCGTVLEAAKLAGYLTGLVVTTRITDATP alp_DdisP001_AA YASGVKTYNNAVGVDAN------------GKPAGTIIEAAKKLGMKTGLVVTTRISDATP CG5361_DmelP010_AA LWLGIPLD------KVPDNQQDCGRLFNATQGPISILRQAQLAGLRTGFVTTQRITG--P CG16771_DmelP004_AA LFGGVKVNYETGGVDANVPLGNCSASLKEDHHVQTILKWAQVDGMRTGFVTTTRVTHATP Aph-4_DmelP001_AA IFSGSKTHYGAIGMDATRSKKNGQ-----QGRVQSVMEWAQKEGKRTGVVTTTRITHATP ALP_NvecP001_AA MFTGVKTRSAMIGVNEEVVTNKCETLTE-DRKVDSILKLAEEAGMATGFITSMRLTHATP ALPL_HsapP002_AA YLCGVKANEGTVGVSAATERSRCNTTQ--GNEVTSILRWAKDAGKSVGIVTTTRVNHATP ALPI_HsapP001_AA YLCGVKANFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKQAGKSVGVVTTTRVQHASP ALPP_HsapP003_AA YLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKKAGKSVGVVTTTRVQHASP ALPPL2_HsapP004_AA YLCGVKGNFQTIGLSAAARFNQCNTTR--GNEVISVMNRAKKAGKSVGVVTTTRVQHASP ALP-d_SpurP004_AA IFGGVKTKDGVLGLDDDAKRGDCASAT--GNEVASNLHLAHAEGKATGFVTSDSVTGATV ALP-c_SpurP003_AA YLCGVKTKTGVLGVDDRVERGDCVSSL--GGEVKSILEMAQEAGKSVGFVTTTTLTHASP ALP-a_SpurP001_AA YLCGVKSKFGTLGVDDRVERGKCTSIE--GAAVDSILIDSMKAGKSTGLVSTARVTHASP ALP-b_SpurP002_AA FFSGIKTKSGVVGIDDRVEYADCESGL--GGEVDSVLVNAHNIGKATGVISTARITHATP CG10827_DmelP003_AA YLCGVKGQEGTIGVNGQVPRTDCKVMLDESTHVDSIAKWAMEAGKWAGLVTTTRVTHASP CG5150_DmelP009_AA YLCGVKANYGTIGVNAHVKRGDCAAMANETNHVFSLGKWAMDAGKAAGLVTTTRVTHASP CG5656_DmelP011_AA YLSGIKANYLTIGVTADVELNDCRGSRLPQNRLSSIAAWALKGSKSAGLVTTTRVTHASP CG8147_DmelP013_AA YLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASP CG10592_DmelP002_AA YLTGVKANYGTIGVNAQVQRGDCVTNS--SSHVQSIGQWAQEAGKWAGLVTTARVTHASP CG1809_DmelP005_AA YLGGVKANYGTIGVNANVSRYSCDGAANEEDRVLSIAHWAQAAGKDAGLVTTARVTHASP CG8105_DmelP012_AA YFGGVKTHSGTVGQSGS------------GERVDSVLQWAQRAGKATGVVTTTRLTDASP CG3292_DmelP008_AA YLCGVKTNIVALGITAAVSFNNCSGSEDPANQVDSIAAWAQAAGKATGIVTTTTLTHASP CG3264_DmelP006_AA YLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKSTGIVTTTTLTHASP CG3290_DmelP007_AA YLCGVKTNIINIGVSAAVNFNNCTASQDPANRLTSIAEWAQNAGKSTGFVTTTTLTHASP . : : . .*.: : : PHO8_ScerP022_AA ASFSSHVDYR-WQEDLIA-----------------THQLGE--YPLGRVVDLLMGGG--- alp_DdisP001_AA ACYFAHSATR---HDEAF----------------IIDQLLD------KEIDVILGGG--- CG5361_DmelP010_AA TGAALGNANGNFECDESMPLNSI-----KSGCQDIAQQLIS--DETGKFLNVLIGGG--- CG16771_DmelP004_AA AALYAHVPDRRWECESGMPAEAQ-----GQGCMDIARQLIE--QPTGQSINVIMGGG--- Aph-4_DmelP001_AA AATYAHIYDRDWECDTEVPAESV------GFHVDIARQLVE--NAPGNRFNVILGGGMSP ALP_NvecP001_AA ANLYAHSASRYWESDKEMVSRGY---G-NTSCKDMAQQLVDFQGSVGDGIEVVMGGG--- ALPL_HsapP002_AA SAAYAHSADRDWYSDNEMPPEAL-----SQGCKDIAYQLMH----NIRDIDVIMGGG--- ALPI_HsapP001_AA AGTYAHTVNRNWYSDADMPASAR-----QEGCQDIATQLIS-----NMDIDVILGGG--- ALPP_HsapP003_AA AGTYAHTVNRNWYSDADVPASAR-----QEGCQDIATQLIS-----NMDIDVILGGG--- ALPPL2_HsapP004_AA AGAYAHTVNRNWYSDADVPASAR-----QEGCQDIATQLIS-----NMDIDVILGGG--- ALP-d_SpurP004_AA AALYAHSPERDWQSDADIPRK-------QEECNDLAYQLIM----ENDFINVILGGG--- ALP-c_SpurP003_AA GALYAKVPDRKWQSDMDIPRGER-----NLGCVDMAQQFVS-----NNNIQVALGGG--- ALP-a_SpurP001_AA AALYAHTPDRRWENDHDLDDRDK-----REGCKDIALQLIE----HGKNMNVIMGGG--- ALP-b_SpurP002_AA AATYAHVAKRDWEVDTEMIEDGED----GKGCKDIALQLIE----DNPFIKVILGGG--- CG10827_DmelP003_AA SGVYAHIAERDWENDAEVATDCG---A-GSGINDIAYQLAR--GEVGSKLKVIMGGG--- CG5150_DmelP009_AA SGVYAHVADREWENNAVLEEACG---ELSDGLQDIAVQLIH--GEVGSKLKVMLGGG--- CG5656_DmelP011_AA AGVYAHTSNRDFESDYDVTKLGQ---N-PGNCPDIAQQLID--GDVGKRLRVVMGGG--- CG8147_DmelP013_AA AGVYAHLANRNWENDAEVVGDNG---D-PDLCPDAAAQLIN--SPVGQKLNVIMGGG--- CG10592_DmelP002_AA AGVYAHVSERNWEHDGEIISSKC---S-PDVNTDIARQLVE--WPVGQELRVIMGGG--- CG1809_DmelP005_AA AGVYAHIADRNWENDWEVANREC---D-PEQTIDIARQLVE--QPVGQQLKVILGGG--- CG8105_DmelP012_AA AGAYAHVSRR----GEEL---------------EIARQLVE--EEPGRNLNVILGGG--- CG3292_DmelP008_AA SGAYAKTTNRFFESDTDILTYGEGQND-PATCTDIATQLIT--QAPGKNFDVMLGGG--- CG3264_DmelP006_AA SGAYAKTANRMWECDTDVTSYGV---D-ANSCIDMATQLVT--QTPGKNFEVMFGGG--- CG3290_DmelP007_AA SGAYAKTANRMWQSDTDVTSYGV---D-ASTCVDMATQLVT--QTPGKNFEVMFGGG--- *: . : :*** PHO8_ScerP022_AA RSHFYPQGEKASPYGHH----GARKDGRDLIDEA--------QSNGWQYVGD----RKNF alp_DdisP001_AA KQFFSNKTLQDAVS----------------------------SKYNYSYVES----KQEM CG5361_DmelP010_AA -RQMLSSLVPNTKYDPVDEMLCESNDGRNLLKDWRNQKLK--ESKINRIIFDLIQRRDEL CG16771_DmelP004_AA RQMLVSDVTGSAADPLDTWA-GQSKDGRDLIRDWRLKKAD--EGVSHAVVQN----NREL Aph-4_DmelP001_AA MGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHAN--DTVPPALVHN----RKDL ALP_NvecP001_AA RRSFLPNTTRDPEHVNKT---GERYDGRNLIQEW----LN--KREGSVYAWN----KTQF ALPL_HsapP002_AA RKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTW-KSFKP--RYKHSHFIWN----RTEL ALPI_HsapP001_AA RKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEW----LA--KHQGAWYVWN----RTEL ALPP_HsapP003_AA RKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEW----LA--KRQGARYVWN----RTEL ALPPL2_HsapP004_AA RKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEW----LA--KHQGARYVWN----RTEL ALP-d_SpurP004_AA RQEFLPTRVEDPEYYDVT---GRREDGNNLIGQW----QGEKEASSSHYVWN----KEDF ALP-c_SpurP003_AA RMKFMSRINRDPEYPSMP---GSRIDGRNLIQEW-INNKP--DQDRAHYVWN----EADF ALP-a_SpurP001_AA RRELTPRNVEDPEYDGDY---GQRLDGRNLIEDW----LEDKDPMRSHYVWN----LQDF ALP-b_SpurP002_AA RRMFYNNTELDPEDPSDR---GNRTDGRNLIEEW----QN--GKTNARYVWN----KEQF CG10827_DmelP003_AA RKHFVDSSLESW---------GKRTDGLNLIDEF----KS--ASENNVYVTT----AAEL CG5150_DmelP009_AA KRSFYS-----PEHYDK----GRRTDGRNLVEEF----EA--LDAGNTFVKT----QKKL CG5656_DmelP011_AA TIKFLPNTTNDVFGNK-----GQRLDNRNLIEEW---QQT--KPGNARVVFS----RTDL CG8147_DmelP013_AA RENFLPKGVTDSSGAP-----GRRLDGRNLIDEW---KNQ--HTNSAQYVEN----RREL CG10592_DmelP002_AA RSYFRDQSQHDETGVS-----GLRTDGRDLISDWREIKKQ--QGAEGKYVWS----LKGL CG1809_DmelP005_AA RKNFIDATVNDEEGYP-----GKRTDGRHLIRSWLDQKKE--ANVSAKYVWS----RKGL CG8105_DmelP012_AA LGKFA----------------DERRDGKDLLAQW----RE--SNPNGCFSRS----LKEL CG3292_DmelP008_AA IGKFLPNTITDPFNKK-----GERSDGVNLLSRW----QG--LHPGGVLAYN----RNQL CG3264_DmelP006_AA MGKFLPNSIVDSHGNP-----GERSDGVNLLSRW----QG--LHDGGVLVTN----RNQL CG3290_DmelP007_AA MGKFLPKTTKDSHGKY-----GERSDGVNLLSRW----QG--LHDKGVLVTN----RKQL : : PHO8_ScerP022_AA DSLLKS-HGENVTLPFLGLFADNDIPFEIDR----DEKE---YPSLKEQVKVALGALEKA alp_DdisP001_AA EQV----EAGR----ILGLFADYNIPWEIDRLR--DPTLLSTKPSLQEMTTKALNLISQ- CG5361_DmelP010_AA ESLNSS-SFDY----LMGVMANGDLS---------GNSK---APSLKLMVDKSLNVLTK- CG16771_DmelP004_AA WNLNGQ-DVDY----VLGIFANGHLMYDHERDR--SDAG---MPSLSNMTLKALEVLGN- Aph-4_DmelP001_AA LNVNVK-KVDH----LMGLFRNNHITYSIAR-----EAG---EPSLQEMTETALGILER- ALP_NvecP001_AA DAVDPK-TTKH----FLGMFESSHMQFAIDRDE--DVGG---EPSIAEMVEKAVSILKN- ALPL_HsapP002_AA LTLDPH-NVDY----LLGLFEPGDMQYELNR----NNVT---DPSLSEMVVVAIQILRK- ALPI_HsapP001_AA MQASLDQSVTH----LMGLFEPGDTKYEIHR----DPTL---DPSLMEMTEAALRLLSR- ALPP_HsapP003_AA MQASLDPSVTH----LMGLFEPGDMKYEIHR----DSTL---DPSLMEMTEAALRLLSR- ALPPL2_HsapP004_AA LQASLDPSVTH----LMGLFEPGDMKYEIHR----DSTL---DPSLMEMTEAALLLLSR- ALP-d_SpurP004_AA DNVEPT-TTDY----LLGLFEPGRMQYGADRAA--DGAG---EPSLAEMTEKAIKVLGR- ALP-c_SpurP003_AA NKIDPE-QTDY----LLGLFEYSLMKFDIRRDN--DTGG---EPSIAEMTDKAIRILSK- ALP-a_SpurP001_AA NRVNAE-TTDH----LIGLFQPSHMKYETDRRW--DRAG---EPSLAQMTEKAIKILQR- ALP-b_SpurP002_AA DAIDED-TTDY----LFGLFEDSHMRYASES----EEGN---DPSLASMTEKAIKMLQK- CG10827_DmelP003_AA AAVDVT-KTDR----LLGLFNDDHLQYLMETT---TESS---QPTLEQMTRKAIEYMSQ- CG5150_DmelP009_AA LNVNAT-ETGR----LLGLFSKSHMHYHLEQLAD-PDNN---EPTLEEMTQKAIEVLET- CG5656_DmelP011_AA LNNDAQ-NTDF----LLGLFNASHLAYHMD-----DSID---TPTLPEMTAAAINVLSR- CG8147_DmelP013_AA LNLS-N-HTSR----VLGLFAPYHMAYHLDA----SPAE---QPTLEEMVQSAMEILER- CG10592_DmelP002_AA KETDIS-KTDY----LLGLFDTSHLPYHGDRRRTHYEDA---EPSLSDMTEAAIKMLSK- CG1809_DmelP005_AA SLVDLE-NTDY----LLGLFANDHLPYNGDRDRKRSQLA---DPSLSELTEAAITVLSR- CG8105_DmelP012_AA RNCT-D-ATGT----LLGIFSDSHMSYHLAA-----SKE---LPRLCDMAAAAIEKLER- CG3292_DmelP008_AA LSVNVS-KITN----LIGTFRSGVMSFNKMA----DPKE---EPTLAEMTRKAIEVVSK- CG3264_DmelP006_AA LKLNVS-AVSS----VIGLFQSKLMNFHLEA----DDTY---QPTLSELTEVTIKKLSQ- CG3290_DmelP007_AA LNLDVS-AASS----IIGTFQSGLMDFHMDA----DPTY---QPTLSELTEVAIKKLSH- .:* : * : . :: : PHO8_ScerP022_AA SNEDKDSNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAENSD--TETVL alp_DdisP001_AA NNE----NGFFLMVEGSKIDVAAHINDAPTQIWETDAFDQTFNLVREWAEKD---GNTIV CG5361_DmelP010_AA -YK----QGYLLIVE-QFIPSGIDKREQLQLLNDTL---------VNLHKD----QDTLT CG16771_DmelP004_AA -SD----KGFLLVVEAGLIDQAHHRGNARKALSEVLELNAAVESTLSFLKSSDRLDETLV Aph-4_DmelP001_AA -GDES--NGFVLLVEGGRIDQGHHMNYARAALHELYEFDLAIQAAVNNTDP----DETLI ALP_NvecP001_AA -NDNG--KGFFLAVEAGLIDIGHHNGIARQALNEVVNLEEGVAKAVEMTDK----EDTLI ALPL_HsapP002_AA -NP----KGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSS----EDTLT ALPI_HsapP001_AA -NP----RGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSE----EDTLT ALPP_HsapP003_AA -NP----RGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSE----EDTLS ALPPL2_HsapP004_AA -NP----RGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSE----EDTLS ALP-d_SpurP004_AA -DE----DGFFLVVE---------------MLSNFV------------------------ ALP-c_SpurP003_AA -NP----NGFFLFVEGGRIDHGHHFGVANLALTETVAMDKAIDVALGLVDT----EETLV ALP-a_SpurP001_AA TSD----NGFFLFVEAGRIDHGHHDGMALDALTETLALDEAIGVALRLTSA----EDTLI ALP-b_SpurP002_AA -EE----KGFFLAVEGGRIDHAHHAGNAYNALGDAIAMSDAVAMALEMTSD----SDTLI CG10827_DmelP003_AA -NE----QGYFLFIEGGRIDQAHHINQARMALNETIEFSKAIAAAQELTSE----DDTLL CG5150_DmelP009_AA -EE----QGYFLFVEGGKIDISHHETMARIALDETAELSKAVKKAREMTNP----EETLI CG5656_DmelP011_AA -DP----NGYFLFVEGGRIDHAHHETKAKKALDETVQFSDAVRKARQLTNP----WDTLI CG8147_DmelP013_AA -QSAG--RGYFLFVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTST----DDTLI CG10592_DmelP002_AA -NE----EGYFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDE----EDTLI CG1809_DmelP005_AA -ND----KGFFLFVEGARIDMAHHDTFAKRSLEDTAEFARAVQKARELTSE----DDTLI CG8105_DmelP012_AA -KSQEDGNGYFVFIEGGRIDHGHHETRVGYALDEMVEFDAAVETVIQMTDP----RDTLV CG3292_DmelP008_AA -RD----GGYFLFVEGGLIDYGNHFNSPTYSLSETLQFEQAVQEALDITDP----EETLI CG3264_DmelP006_AA -NKE---HGYFAFIEGGLIDYGNHYTKAGYALDEALEFEKAIQLARDMTDI----EDTLI CG3290_DmelP007_AA -NE----NGYFVFIEGGLIDYGNHYTQAGYALDEALEFEKAIQLAREMTNI----SDTLI *: :* : : PHO8_ScerP022_AA VSTSDHETGGLVTSRQVT-ASYPQYVWYPQVLANATHSGEFLKRKLVDFVHEHKGASSKI alp_DdisP001_AA IVTADHETGGLTLANQMVIDGNPKYSWSPE--------------TLLTVNKSADLMAELI CG5361_DmelP010_AA LVLMTN-------------AIYPK--------------------PSLDVSEETETI---- CG16771_DmelP004_AA IVTADH-------SHSLTINGHPDRGS-----------------SILGLAGNSKT----- Aph-4_DmelP001_AA LVTADH-------SHAVTFNGYALRGA-----------------DILGTANSHEKN---- ALP_NvecP001_AA ISTADH-------GHVFTLTGYPDINS-----------------PIFGLMKQDGEVKLAL ALPL_HsapP002_AA VVTADH-------SHVFTFGGYTPRGN-----------------SIFGLAPMLSDT---- ALPI_HsapP001_AA LVTADH-------SHVFSFGGYTLRGS-----------------SIFGLAPSKAQ----- ALPP_HsapP003_AA LVTADH-------SHVFSFGGYPLRGS-----------------SIFGLAPGKAR----- ALPPL2_HsapP004_AA LVTADH-------SHVFSFGGYPLRGS-----------------SIFGLAPGKAR----- ALP-d_SpurP004_AA -------------CHV-----------------------------TIGIVDDQESA---- ALP-c_SpurP003_AA MVTSDH-------AHTFKMAGYSARGN-----------------PILGKSDGRST----- ALP-a_SpurP001_AA VSTADH-------AHVMTMAGYASRGN-----------------PILGLEDHYLAD---- ALP-b_SpurP002_AA VVTADH-------AHTMSIGGYPDRGN-----------------KILGLAGYFGS----- CG10827_DmelP003_AA VVTADH-------SHVFTYAGYSYRGS-----------------DVFGKTPVNGH----- CG5150_DmelP009_AA VVTSDH-------SHTFSVSGYQPRGS-----------------DIFGAAKANGK----- CG5656_DmelP011_AA VVSADH-------GHTVTISGYPDVNN-----------------SIVGLNSELSNV---- CG8147_DmelP013_AA VVSSDH-------SHTMSLAGYSSRKN-----------------DIFGINDGQLAA---- CG10592_DmelP002_AA VVTSDH-------SHTMSINGYPYRRQ-----------------NILSLAPNLAD----- CG1809_DmelP005_AA VVTADH-------AHVMSINGYPYRDQ-----------------EITGLAQLAD------ CG8105_DmelP012_AA VVTADH-------SHTLSMSGYAKRGT-----------------PILGMDAQQRDV---- CG3292_DmelP008_AA VVTSDH-------AHPLTISGYPGRGT-----------------PILGLNQDDTDV---- CG3264_DmelP006_AA VVTADH-------GHAVSIAGYPGRGT-----------------PILGINQHDTDI---- CG3290_DmelP007_AA VVTADH-------GHAVSIAGYPGRGT-----------------PILGLNQHDTDI---- PHO8_ScerP022_AA ENFIKHEILEKDLGIYDYTDSDLETLIHLDDNA-------NAIQDKLNDMVSFRA-QIGW alp_DdisP001_AA KGGADPTKLIFDN-TGYTLTSDDLKEINRTKSA-------YYLNQVIGRIVSNYA-DIGF CG5361_DmelP010_AA -SLLPEIF--------------------------------NEAES-EIQKRLHQ---MPS CG16771_DmelP004_AA -EGTPYTTLTY--GTSYQGFQVDPQT-QSRKDP-------TADDI-TAWEYTQQA-AINT Aph-4_DmelP001_AA -DPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEER-AAPTYRHLA-TVPR ALP_NvecP001_AA NDNKPYTILGYMNGPGAVK--------GVRANL-------TGVDT-GAKDFKQQALYIGY ALPL_HsapP002_AA -DKKPFTAILYGNGPGYKVVG------GERENV-------SMVDY-AHNNYQAQS-AVPL ALPI_HsapP001_AA -DSKAYTSILYGNGPGYVFNS------GVRPDV-------NESES-GSPDYQQQA-AVPL ALPP_HsapP003_AA -DRKAYTVLLYGNGPGYVLKD------GARPDV-------TESES-GSPEYRQQS-AVPL ALPPL2_HsapP004_AA -DRKAYTVLLYGNGPGYVLKD------GARPDV-------TESES-GSPEYRQQS-AVPL ALP-d_SpurP004_AA -DRLPYTTLTYLNGPGGVNVQTNWANNGNRRDY-------SGVDT-ESRTWQQDA-IIPL ALP-c_SpurP003_AA -DLGSYTTVGYMNGPGAIISSLSYRLLGRRPPV-------TDANT-GRPFYLPQA-VVPT ALP-a_SpurP001_AA -DDLPYATLSYANGPGARHMASSFQKHGARENL-------TSVDT-EETGHRQQA-LVPF ALP-b_SpurP002_AA -DDLPFTTLGYLNGPGAEEVRQSYSDTGMRPNL-------TEIDT-EDKDYLQQA-IVPL CG10827_DmelP003_AA -DGKPYMVLSYANGPSYENFYDAET--MERKDP-------TTVVK-GDHDDEFPS-GVPI CG5150_DmelP009_AA -DGKPYLALSYANGKSFQDYYNTET--HERVDP-------TSLPTIGDFDQLFPA-MVPL CG5656_DmelP011_AA -DQLPYTSISYANGPAYERFYKSTDGVVERVDL-------RNLDF-SKPDAIYPH-GVPM CG8147_DmelP013_AA -DDLPYATLSYANGPGYDSNYLREGGAVRRKNL-------RAINM-KNKDFMFPS-TVPL CG10592_DmelP002_AA -DELPFTILSYANGPGFDDTYSTK---DGRIDL-------SHADT-TSAEFEFQA-TVPL CG1809_DmelP005_AA -DNLPYTILSYANGPGYYSGYNRA---EGRALL-------KEKLV-ADSDYQYPT-LAPL CG8105_DmelP012_AA -NGVPYSTLNYAIGKWQSLDKD-----GRRESP-------SKTLS---PTSYTPS-YIHG CG3292_DmelP008_AA -NGVKYATLNYAVGTNQYLDEH-----GQRIDL-------TDQI--GAEDFIHPS-YIHG CG3264_DmelP006_AA -NGVQYSVLNYAAGPNQYLDEN-----GQRIPL-------DDIL--GSDDAITPS-YIPK CG3290_DmelP007_AA -NGVKYSVLNYAAGPNQYLDEH-----GQRIPL-------DDIL--GPDDAISPS-YIDK PHO8_ScerP022_AA T-THGHSAVDVNIYA-------YANKKAT---------------WSYVLNNLQGNHENTE alp_DdisP001_AA T-TGGHTGEDVNLYT-------FGDTISEGKFETRLKDHQTEIVDNYIDPILRGNINNID CG5361_DmelP010_AA E---------SLLFA-------QG----P---------------KSSI---FQGVRKETF CG16771_DmelP004_AA D-ENLHGGSDVTIHA-------DG----A---------------MSYL---FHGVHEQSY Aph-4_DmelP001_AA K-DETHGGEDVAVFA-------YG----P---------------GSSL---IRGVFEQNY ALP_NvecP001_AA DYDEAHGSQDVGIYS-------RG----P---------------WAHL---LTGVVEQNV ALPL_HsapP002_AA R-HETHGGEDVAVFS-------KG----P---------------MAHL---LHGVHEQNY ALPI_HsapP001_AA S-SETHGGEDVAVFA-------RG----P---------------QAHL---VHGVQEQSF ALPP_HsapP003_AA D-EETHAGEDVAVFA-------RG----P---------------QAHL---VHGVQEQTF ALPPL2_HsapP004_AA D-GETHAGEDVAVFA-------RG----P---------------QAHL---VHGVQEQTF ALP-d_SpurP004_AA E-AETHGGADVPVYA-------QG----P---------------WSHM---FAGVHEQNY ALP-c_SpurP003_AA F-LETHGGDDVAIFA-------IG----P---------------MSHL---VHGVHEQNY ALP-a_SpurP001_AA D-EETHGGQDVMVYA-------RG----P---------------MAHL---FHGVQEQSY ALP-b_SpurP002_AA S-SESHGGDDVAIYA-------TG----P---------------MAHL---FHGVQEQSY CG10827_DmelP003_AA D-MDSHGGDDVPVYA-------LG----P---------------WAHL---FTGVYEQST CG5150_DmelP009_AA E-SETHGGEDVGVFA-------SG----P---------------WAHL---FTGVYEQNT CG5656_DmelP011_AA T-EETHGGGDVAVYAHVVEYLLQG----P---------------WSHL---FTGVYEQST CG8147_DmelP013_AA E-SETHGGDDVAVFA-------SG----P---------------YAQL---FTGVFEQHF CG10592_DmelP002_AA S-SETHGAEDVGVFA-------SG----P---------------FEHL---FTGNYEQSA CG1809_DmelP005_AA D-AETHGGDDVAVYA-------SG----P---------------YAQY---FSGNYEQSN CG8105_DmelP012_AA R-KGVHSGEDVVVFA-------MG----P---------------QSHL---FGGVMEQNL CG3292_DmelP008_AA T-IGVHAGDDVGIFA-------TG----P---------------QSHL---FTGVMQQST CG3264_DmelP006_AA D-QGVHSGEDVGIFA-------SG----P---------------QSHL---FTGVMQQST CG3290_DmelP007_AA E-IGVHSGEDVGIWA-------SG----P---------------QSHL---FTGVMQQST : : . . * :: PHO8_ScerP022_AA VGQFLENFLEL-----------------------------NLNEVTDLIRDTKHTSDFDA alp_DdisP001_AA IASFIIKTLNL-----------------------------DIQSITESLKDFIPKP---- CG5361_DmelP010_AA LAHAISHVLSR-----------------------------SRVRP--------------- CG16771_DmelP004_AA VAHAISYALRI-GRF-------------------------RDSSIAETLAELTPI----- Aph-4_DmelP001_AA LAYVMSYAGCL-GPAKDFDDSCEDH---------------KDGQKDRPLDKPNPKRNGAT ALP_NvecP001_AA IFHVMDHALCLSSSKQGTCS--------------------KPEARGGPSASAAMVTALFA ALPL_HsapP002_AA VPHVMAYAACI-GANLGHC---------------------APASSAGSLAAGPLLLALAL ALPI_HsapP001_AA VAHVMAFAACL-EPYTA-C---------------------DLAPPACTTDAAHPV----A ALPP_HsapP003_AA IAHVMAFAACL-EPYTA-C---------------------DLAPPAGTTDAAHPGRSVVP ALPPL2_HsapP004_AA IAHVMAFAACL-EPYTA-C---------------------DLAPRAGTTDAAHPGPSVVP ALP-d_SpurP004_AA IAHAVRHAACLDAAASSAC---------------------DLSATQDDVMEVRGARPAYQ ALP-c_SpurP003_AA VSHVMQRAACI-GYYADNC---------------------QPVQAAAGDDDFGTLSDATA ALP-a_SpurP001_AA IPHVIRYAACL-AGETEHCTNGQARWCEGGTASASSSSKTKEQAEVEAHVGASAVRRTHG ALP-b_SpurP002_AA IAHVMRNAGCYDETDTMNA---------------------CLNLNSASSNIPSALRVSLM CG10827_DmelP003_AA IPHMMAYASCL-GDGHTMC---------------------K------------------- CG5150_DmelP009_AA IPHMMAFAACV-GDGLTAC---------------------D------------------- CG5656_DmelP011_AA LPHLMGFASCL-GPGITYC---------------------DLQPKARYSP---------- CG8147_DmelP013_AA IPHALGYASCL--SDRNMC---------------------VDGGVARRPR---------- CG10592_DmelP002_AA IPAMMAYAANI-GPFAK-----------------------DKINEQ-------------- CG1809_DmelP005_AA IPALMARAAGI-GPYA-------------------------------------------- CG8105_DmelP012_AA LPHIMGYAACL-GNGLTLC---------------------NQDKDADMIA---------- CG3292_DmelP008_AA IPHLMAYASCI-GNGPTLC---------------------DNED---------------- CG3264_DmelP006_AA IPHLMAYAACI-GSGKQVC---------------------DN------------------ CG3290_DmelP007_AA IPHLMAYASCV-GSGKQVC---------------------GSSGRKT------------- : : PHO8_ScerP022_AA TEIASEVQHYDEYYHELTN---- alp_DdisP001_AA ----------------------- CG5361_DmelP010_AA ----------------------- CG16771_DmelP004_AA ----------------------- Aph-4_DmelP001_AA VVGASLIPILTAATAAILRGRGL ALP_NvecP001_AA PLVAALVTCLVLY---------- ALPL_HsapP002_AA YPLSVLF---------------- ALPI_HsapP001_AA ASLPLLAGTLLLLGASAAP---- ALPP_HsapP003_AA ALLPLLAGTLLLLETATAP---- ALPPL2_HsapP004_AA ALLPLLAGTLLLLGTATAP---- ALP-d_SpurP004_AA KR--------------------- ALP-c_SpurP003_AA LRVDAKLGILLVFSVLLALVKIA ALP-a_SpurP001_AA GMFQVIACAFLASCIRWMLQTTA ALP-b_SpurP002_AA ALLSAMITYFF------------ CG10827_DmelP003_AA ----------------------- CG5150_DmelP009_AA ----------------------- CG5656_DmelP011_AA ----------------------- CG8147_DmelP013_AA ----------------------- CG10592_DmelP002_AA ----------------------- CG1809_DmelP005_AA ----------------------- CG8105_DmelP012_AA ----------------------- CG3292_DmelP008_AA ----------------------- CG3264_DmelP006_AA ----------------------- CG3290_DmelP007_AA -----------------------