CLUSTAL W (1.81) multiple sequence alignment Mbre_mbre_29484.AA ------------------MAGAPGAMVDLHAIFNDITKSQHRIEAACRGIQQAEAQFSDN Cele_eya-1.AA -------------------------------MLPDSEGQKLKTFLLGTGTTLDPSLDPTG Dmel_eya.AA ----------------MVTLMPYNYAAPRCGLIDKMIEPKVKRP----KTDHTDTHERNR Hsap_EYA2.AA -------------------------------MVELVISPSLTVN------SDCLDKLKFN Hsap_EYA3.AA -----------------------------MEEEQDLPEQPVKKA----KMQESGEQTISQ Nvec_nvec_116873.AA ------------------------------------------------------------ Hsap_EYA1.AA ------------------------------MEMQDLTSPHSRLS----GSSESPSGPKLG Hsap_EYA4.AA -MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLV-----GGGDTPGSSKLE Spur_spur_hmm134186.AA ---------------------------------------------------MGTAASKNQ Spur_spur_hmm43544,hmm216903.AA MDHEDEDVRQVKRARTETEGDSNTPTPTRSLEIQQLSSPHSQVS-----NANGSSPQHAN Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA LLHELFQTLAKGDEARNIACCYLLDYVFANADGPFCQALRQNMPILYGLALPDKPAFKSH Cele_eya-1.AA NSNFSMATTSDS------------------------------------------------ Dmel_eya.AA LCNLSQQQQQQQPQQQQTHQQQQQQQQQSHQQSHSSTVLASNGPSSAGAGMGVGVGGGGG Hsap_EYA2.AA RADAAVWTLSDR------------------------------------------------ Hsap_EYA3.AA VSNPDVSDQKPE--------------------------------------------TSSL Nvec_nvec_116873.AA ------------------------------------------------------------ Hsap_EYA1.AA NSHINSNSMTPNGTE----------------------------VKTEPMSSSETASTTAD Hsap_EYA4.AA KSNLSSTSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEPLNSSETTATTGD Spur_spur_hmm134186.AA RSTVVSNCQQPT------------------------------------------------ Spur_spur_hmm43544,hmm216903.AA SPDSNNCSVTSNGTDR-------------------------------------------- Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA NKLKKLYDRWVKKNWIPEAEAALTDMAPAVAYRRTQKLLHSTPTSIAHARVVANEVPVTS Cele_eya-1.AA ----------------------STIWTALPA-------------SQPGDKDIPTVDLAAI Dmel_eya.AA SGGGVG----------GGVGQCSPLGLPPQSQPLQPTIGSLASLSGHYSNGNANPNVNSS Hsap_EYA2.AA --------------------QGITKSAPLRVSQLF---------SRSCPRVLPRQPSTAM Hsap_EYA3.AA ASNLPM----------SEEIMTCTDYIPRSSNDYTSQM--YS--AKPYAHILSVPVSET- Nvec_nvec_116873.AA ------------------------------------------------------------ Hsap_EYA1.AA GSLNNF----------SGSAIGSSSFSPRPTHQFSPPQIYPS--NRPYPHILPTPSSQTM Hsap_EYA4.AA GALDTF----------TGSVITSSGYSPRSAHQYSPQLYP----SKPYPHILSTPAAQTM Spur_spur_hmm134186.AA -------------------------------------------------RLL-------- Spur_spur_hmm43544,hmm216903.AA ----------------SSSGQSSLDMNLRQPKSEFPSQYY----SQAYPHILPTPTAQGA Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA P-EHPTTLQLRNLYRNRN----TIQSPNPNPSNPSNLG---------------------N Cele_eya-1.AA SEAYGSTSSTTSLTSSVTSQYQYNSYPQ---------Y---------------------- Dmel_eya.AA S-CSLATASSFAQSAGSS----FSTYQQAGGTSGGVSGEDGVVGGATVMSHWTHDGTGSS Hsap_EYA2.AA A-AYGQTQYSAGIQQATP----YTAYPPPAQAYGIPSY---------------------- Hsap_EYA3.AA --AYPGQTQYQTLQQTQP----YAVYPQATQTYGLPPF---------------------- Nvec_nvec_116873.AA ------------------------------------------------------------ Hsap_EYA1.AA A-AYGQTQFTTGMQQATA----YATYPQPGQPYGISSY---------------------- Hsap_EYA4.AA S-AYAGQTQYSGMQQPAV----YTAYSQTGQPYSLPTY---------------------- Spur_spur_hmm134186.AA --NHRAQVRRASRRESEE-----------------PEY---------------------- Spur_spur_hmm43544,hmm216903.AA N-FQPVGSQTQGTFGSQS----ASSYPYSTQTSPSP-Y---------------------- Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA PSNKRSHNKRTALPNFLWRPLTLAGDWLTLERTVSDDWYEGTNLRTGARGIYPVA----- Cele_eya-1.AA ----------------------------AMYTSANP------------ANY--------- Dmel_eya.AA AAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASNP----------LDGGAVAVNSSAVA Hsap_EYA2.AA -------------------SIKTED-----SLNHSP----------GQSGFLS------- Hsap_EYA3.AA --------------GALWPGMKPES---GLIQTPSP----------SQHSVLT------- Nvec_nvec_116873.AA ------------------------------------------------------------ Hsap_EYA1.AA --------------GALWAGIKTEG---GLSQSQSP----------GQTGFLS------- Hsap_EYA4.AA ------------DLGVMLPAIKTES---GLSQTQSP----------LQSGCLS------- Spur_spur_hmm134186.AA ---------------VLLPGIKNEK---FYANLHTP----------LNLELLG------- Spur_spur_hmm43544,hmm216903.AA --------------GLVGQAMSYGAKSLKSDPATLQ----------GQGSYLST------ Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA --------------YVEQTQLAPPPQAPPAHHPPAGFGAPFPPPGVWAAGAPGH----AG Cele_eya-1.AA --------------Y--QQVTANLRAGTTAFPYSLTTPSYYGSYPVDYTSAAAA------ Dmel_eya.AA AAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAKMEPGAAAAAAAYLTP Hsap_EYA2.AA --------------Y--GSSFSTSPTGQSPYTYQMHGTT-----GFYQGGNGLG------ Hsap_EYA3.AA --------------C--TTGLTTSQPSPAHYSYPIQASS--TNASLISTSSTIA------ Nvec_nvec_116873.AA ------------------------------------------------------------ Hsap_EYA1.AA --------------Y--GTSFSTPQPGQAPYSYQMQGSSFTTSSGIYTGNNSLT------ Hsap_EYA4.AA --------------Y--SPGFSTPQPGQTPYSYQMPGSSFAPSSTIYA-NNSVS------ Spur_spur_hmm134186.AA ----------------DVPTASSTAPGLNSNAI-LDGIPAKDRAGIDTSSSEST-----S Spur_spur_hmm43544,hmm216903.AA --------------YGSSSFTGSPQATQSPY-YGMQGTFTTAGYTYPSTSNTTT------ Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA PPANANFPPPHNAGTNYPPPTNAGFQPSFYPPHNQFAAPPSQFAQPPFPAHQHQAQ---- Cele_eya-1.AA ----------------YQNPYYTNLRGGTAAPY---------YN--PLNATTAAAY---- Dmel_eya.AA SYAASGNNNSQLYSSPY--AGYNNFGQQDYGGY---------YNEQ-YGNYYSPANYSPY Hsap_EYA2.AA --NAAGFGSVHQD---Y--PSYPGFPQSQYPQY---------YGSS-YNPPYVPAS---- Hsap_EYA3.AA --NIPAAAVASISNQDY--PTYTILGQNQYQAC---------YPSSSFGV-TGQTN---- Nvec_nvec_116873.AA ------------------------------------------------------------ Hsap_EYA1.AA --NSSGFNSSQQD---Y--PSYPSFGQGQYAQY---------YNSSPYPAHYMTSS---- Hsap_EYA4.AA --NSTNFSGSQQD---Y--PSYTAFGQNQYAQY---------YSASTYGA-YMTSN---- Spur_spur_hmm134186.AA SISSTKSVTEELD------ALRTELDQVLVGHY---------YANNKPAGGVLRTA---- Spur_spur_hmm43544,hmm216903.AA --NSQGFNSTHQG-VEY--GSYTAYSQTGFNQY---------YASQNYSPYSMSNS---- Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA ------------QPFPPPQGMHPQSLPVHVPQNQPEAQVQVQAQPQGPALVP-------- Cele_eya-1.AA ----------------------------ASVASSVLGTDAVNLGTSSDGSTG-------- Dmel_eya.AA AVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPL Hsap_EYA2.AA ----------------------------SICPS-PLSTSTYVLQEASHNVPN-------- Hsap_EYA3.AA ----------------------------SDAESTTLAATTYQSEKPSVMAPA-------- Nvec_nvec_116873.AA ------------------------------------------------------------ Hsap_EYA1.AA ----------------------------NTSPTTPSTNATYQLQEPPSGITS-------- Hsap_EYA4.AA ----------------------------NTADGTPSSTSTYQLQESLPGLTN-------- Spur_spur_hmm134186.AA --------------------------------EIASLERHNQLQPLPQDYK--------- Spur_spur_hmm43544,hmm216903.AA ----------------------------LSASTPLPNTTTYQLAPLPSDIEN-------- Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA -QPGPQPSNQLQTQSQVPRHSTTHALPSKRAASSDRGGSRPAKQPARDDEMAPNDPNASM Cele_eya-1.AA -VPSTVTSFSL--------------------------KEKKPKVSKKKKTGSCSPGDETY Dmel_eya.AA GNVSAAAAAAALNSSGG--SSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTAS Hsap_EYA2.AA -QSSESLAGEY---NTH--NGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEI Hsap_EYA3.AA -PAAQRLSSGDPSTSPS--LSQTTPSKDTD-DQSRKNMTSKNRGKRK--ADATSSQDSEL Nvec_nvec_116873.AA -----------------------------------------GRGRRSTSSAPTPELDHSL Hsap_EYA1.AA -QAVTDPTAEY---STI--HSPSTPIKDSDSDRLRRGSDGKSRGRGRRNNNPSPPPDSDL Hsap_EYA4.AA ------QPGEF---DTM--QSPSTPIKDLD-ERTCRSSGSKSRGRGRK-NNPSPPPDSDL Spur_spur_hmm134186.AA -PVIRDTTKDG--------HSDSDWVRPVDLVRQERDLADRKLERELRSFEQDTKEE--- Spur_spur_hmm43544,hmm216903.AA -TFTTDASIKLDDANGI------GRGRQGQGQGPKNGNRTKSAGRSRR-NNPSPPPEDGL Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA SAKLTYQRRLADRPEELPYQIGLPSPLVEVPTKISAPPTVFIWDLDETLVVFNELTNG-R Cele_eya-1.AA -----------AR--------------------------VFIWDIDDIAVISRNYLASVT Dmel_eya.AA DTGNSEAVKPPER--------------------------VFVWDLDETLIIFHTLLSG-S Hsap_EYA2.AA -----------ER--------------------------VFVWDLDETIIIFHSLLTG-T Hsap_EYA3.AA -----------ER--------------------------VFLWDLDETIIIFHSLLTG-S Nvec_nvec_116873.AA -----------ER--------------------------IFIWDLDETIIIFHSLLTG-L Hsap_EYA1.AA -----------ER--------------------------VFIWDLDETIIVFHSLLTG-S Hsap_EYA4.AA -----------ER--------------------------VFVWDLDETIIVFHSLLTG-S Spur_spur_hmm134186.AA -----------EK----------------------------------------------- Spur_spur_hmm43544,hmm216903.AA -----------ER--------------------------VFVWDLDETIIIFHSLLTG-S Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA FARAYSLDVNTGKYTGRALEKLVFRVLDNKLFFK-KLEKMSECMLE------SRLLLQVS Cele_eya-1.AA HTNEFYARAANSVS-HLMERIALNNFADVNEFLEGDITNIEDAVVDETTMDSGPID---- Dmel_eya.AA YANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFN-EIEECDQVHIDDVSSDDNGQDLSAY Hsap_EYA2.AA FASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFN-DLEDCDQIHVDDVSSDDNGQDLSTY Hsap_EYA3.AA YAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFN-DLEECDQVHVEDVASDDNGQDLSNY Nvec_nvec_116873.AA FATKFGKDSPSSVALGLRMEEMIFNLADTHMFFN-DLEDCDQVHIDDVAADDNGLDLSTY Hsap_EYA1.AA YANRYGRDPPTSVSLGLRMEEMIFNLADTHLFFN-DLEECDQVHIDDVSSDDNGQDLSTY Hsap_EYA4.AA YAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFN-DLEECDQVHIDDVSSDDNGQDLSTY Spur_spur_hmm134186.AA -----KEETQSSV--------IVFDMEDDQDRGDFDVQKFQAVNVPKQEPITEGVDI--- Spur_spur_hmm43544,hmm216903.AA YATRFGKDAPAAVSLGLRMEEMIFNLADMHLFFN-DLEECDQVHIDDVASDDNGQDLSNY Spur_spur_hmm43544,hmm216903_lik ------------------------------------------------------------ Mbre_mbre_29484.AA SLIMGWLDRARTGA---DLRVARC-------LRECKAIYTKFQELRAQPTHRA-IADL-- Cele_eya-1.AA -----------------NLR-------GLDVMRRVAPKYSAFRQFYTENSTKNDVAGFKQ Dmel_eya.AA NFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIY--NSYRGNVGTL-- Hsap_EYA2.AA NFSADGFHSSAPGA---NLCLGSGVHGGVDWMRKLAFRYRRVKEMY--NTYKNNVGGL-- Hsap_EYA3.AA SFSTDGFSGSGGSG---SHGSSVGVQGGVDWMRKLAFRYRKVREIY--DKHKSNVGGL-- Nvec_nvec_116873.AA NFEADGFHAAATSA---NLCMATGVRGGVDWMRKLAYRYRKIKEVY--SSYRNNVGGL-- Hsap_EYA1.AA NFGTDGFPAAATSA---NLCLATGVRGGVDWMRKLAFRYRRVKEIY--NTYKNNVGGL-- Hsap_EYA4.AA SFATDGFHAAASSA---NLCLPTGVRGGVDWMRKLAFRYRRVKELY--NTYKNNVGGL-- Spur_spur_hmm134186.AA -FSQTTYKNYSSTKKKQVISDASSVNPRISEIAETS-----TKQIY-DPSEEELLRRL-- Spur_spur_hmm43544,hmm216903.AA NFQTDGFHAAATSA---NLCLATGVRGGVDWMRKLAYRYRRIKEIY--SSYKNNVGGL-- Spur_spur_hmm43544,hmm216903_lik --------------------------------------------------------GL-- : Mbre_mbre_29484.AA --------------KKTIPQGLDLRQGEKLYALEEPEGGWV-LARREDGSEQGLAPTTYL Cele_eya-1.AA EQNGFNFELLERVGFGAREATELYQSAIQLQTLPNFGQRWP-CAQRCMDLVVEKSKLSAE Dmel_eya.AA --------------LGPGKREAWLQIRSEIEVATDN---WATLALKCLSMISQRE----- Hsap_EYA2.AA --------------IGTPKRETWLQLRAELEALTDL---WLTHSLKALNLINSRP----- Hsap_EYA3.AA --------------LSPQRKEALQRLRAEIEVLTDS---WLGTALKSLLLIQSRK----- Nvec_nvec_116873.AA --------------LGAAKRETWLQLRMELESTTDS---WLTLALKALSIIHSRT----- Hsap_EYA1.AA --------------LGPAKREAWLQLRAEIEALTDS---WLTLALKALSLIHSRT----- Hsap_EYA4.AA --------------LGPAKRDAWLQLRAEIEGLTDS---WLTNALKSLSIISTRS----- Spur_spur_hmm134186.AA --------------LGPQKREQWLQLRAEIEAMTDS---WLTIALKSLSIIHSRS----- Spur_spur_hmm43544,hmm216903.AA --------------LGPQKREQWLQLRAEIEAMTDS---WLTIALKSLSIIHSRS----- Spur_spur_hmm43544,hmm216903_lik --------------LGPQKREQWLQLRAEIEAMTDS---WLTIALKSLSIIHSRS----- . . :: : * : . Mbre_mbre_29484.AA EAINGIQKAFQELKVLDEDDEYEAIDNILADVKYVCLRVAVRTYTEDWCD-VARRALEAC Cele_eya-1.AA KYANVVLSNDGLVLGAAQLMISGLNSSVPVENIYSISKQGKESVFEKIQSRFGKKCSFIC Dmel_eya.AA NCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKSTYVV Hsap_EYA2.AA NCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVV Hsap_EYA3.AA NCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVV Nvec_nvec_116873.AA NCLNIMVTTTQLVPALAKSLLYGLGALFPIENIYSATKIGKEACFERILNRFGKKCTYIV Hsap_EYA1.AA NCVNILVTTTQLIPALAKVLLYGLGIVFPIENIYSATKIGKESCFERIIQRFGRKVVYVV Hsap_EYA4.AA NCINVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVV Spur_spur_hmm134186.AA NCINVLVTTTQLVPAVAKVLLYGLGGVFNIENVYSATRVGKESCFERIVARFGRKVTYVA Spur_spur_hmm43544,hmm216903.AA NCINVLVTTTQLVPAVAKVLLYGLGGVFNIENVYSATRVGKESCFERIVARFGRKVTYVA Spur_spur_hmm43544,hmm216903_lik NCINVLVTTTQLVPAVAKVLLYGLGGVFNIENVYSATRVGKESCFERIVARFGRKVTYVA : * : . : . : * . . : * .... Mbre_mbre_29484.AA VRSPKNKPASTVSNTSPVGLTNASSSARQLNNAL-------- Cele_eya-1.AA ITSG-DTANSAKRLNIPVWPLNSNTDLDKLYSALD-NFLLGG Dmel_eya.AA IGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL--- Hsap_EYA2.AA IGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL--- Hsap_EYA3.AA IGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL--- Nvec_nvec_116873.AA VGDGRDEETASRQMNFPFWRVNTHSDLINLHHALDLGHL--- Hsap_EYA1.AA IGDGVEEEQGAKKHAMPFWRISSHSDLMALHHALELEYL--- Hsap_EYA4.AA IGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL--- Spur_spur_hmm134186.AA IGDAKDEETAAKQLDFPFWRVTSHSDLAALHHALDLGYL--- Spur_spur_hmm43544,hmm216903.AA IGDAKDEETAAKQLDFPFWRVTSHSDLAALHHALDLGYL--- Spur_spur_hmm43544,hmm216903_lik IGDAKDEETAAKQLDFPFWRVTSHSDLAALHHALDLGYL--- : . : .: *. . . * **