CLUSTAL W (1.81) multiple sequence alignment Ddis_spnA.AA MKKMLFMNKKEKKEEQSPAHSSLAQQHQLAQQQYQLQQQQLQLQYQQHQQQLQLAQQQKQ Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ------------------------------------------------------------ Aque_g31493.t1.AA ------------------------------------------------------------ Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ------------------------------------------------------------ Hsap_ILKAP.AA ------------------------------------------------------------ Spur_spur_hmm167846,hmm226318.AA ------------------------------------------------------------ Spur_spur_hmm26051,hmm138463.AA ------------------------------------------------------------ Ddis_spnA.AA NEQNLAQLSTSTSSNSSVNNTTNTNTNTTNSSSISSNNNNNNNTAVPILKAHDFCGTIMI Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ------------------------------------------------------------ Aque_g31493.t1.AA ------------------------------------------------------------ Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ------------------------------------------------------------ Hsap_ILKAP.AA ------------------------------------------------------------ Spur_spur_hmm167846,hmm226318.AA ------------------------------------------------------------ Spur_spur_hmm26051,hmm138463.AA ------------------------------------------------------------ Ddis_spnA.AA LGHTESGKTTLQRQLEFIYGVTDPTDAKHYQRLIYGNTLATLIRFIENSERLNITLSPDN Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ------------------------------------------------------------ Aque_g31493.t1.AA ------------------------------------------------------------ Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ------------------------------------------------------------ Hsap_ILKAP.AA ------------------------------------------------------------ Spur_spur_hmm167846,hmm226318.AA ------------------------------------------------------------ Spur_spur_hmm26051,hmm138463.AA ------------------------------------------------------------ Ddis_spnA.AA LARVKRIQSQPVELARNRLPRFPLKLGWDCKCIWEDKVIQSVYNHSKICSEIRTPGRPKY Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ------------------------------------------------------------ Aque_g31493.t1.AA ------------------------------------------------------------ Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ------------------------------------------------------------ Hsap_ILKAP.AA ------------------------------------------------------------ Spur_spur_hmm167846,hmm226318.AA ------------------------------------------------------------ Spur_spur_hmm26051,hmm138463.AA ------------------------------------------------------------ Ddis_spnA.AA YMDRMFKVFDPSYTPTEMDIISAYDQKDTIQSSAIIHKRFKVDLFGCSGKQSSPKNWVGL Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ------------------------------------------------------------ Aque_g31493.t1.AA ------------------------------------------------------------ Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ------------------------------------------------------------ Hsap_ILKAP.AA ------------------------------------------------------------ Spur_spur_hmm167846,hmm226318.AA ------------------------------------------------------------ Spur_spur_hmm26051,hmm138463.AA ------------------------------------------------------------ Ddis_spnA.AA HQNYKPNYIFYVVALKDYFSDHLVATQNTDPTIVEMCNNHIHRNLLLESLNSFETLTKSE Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ------------------------------------------------------------ Aque_g31493.t1.AA --------------MMDLFGSLP------------------------------------- Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ----------MVAPDNEYLLIVIQKVTSHDK----------------------------- Hsap_ILKAP.AA ---------------MDLFGDLPEPERSPRP----------------------------- Spur_spur_hmm167846,hmm226318.AA --------------MFAYIGCHPTDRWNRDT----------------------------- Spur_spur_hmm26051,hmm138463.AA ----------------------------HKD----------------------------- Ddis_spnA.AA LFDKSLAIYLIFNTSDIFYENIKQYDLKSCFSEYEGGNDPEKAVSFISNKFTKFLQNKDK Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ------------------------------------------------------------ Aque_g31493.t1.AA ------------------------------------------------------------ Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ------------------------------------------------------------ Hsap_ILKAP.AA ------------------------------------------------------------ Spur_spur_hmm167846,hmm226318.AA ------------------------------------------------------------ Spur_spur_hmm26051,hmm138463.AA ------------------------------------------------------------ Ddis_spnA.AA PYKSHIVNLLDKNNVREEFEGIFDSLKIDAEKRGFTTPYNQSNSSPVSSIGSNSSRNSRL Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ------------------------------------------------------------ Aque_g31493.t1.AA ------------------------------------------------------------ Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ----------------------------------------------------------DV Hsap_ILKAP.AA ------------------------------------------------------------ Spur_spur_hmm167846,hmm226318.AA ------------------------------------------------------------ Spur_spur_hmm26051,hmm138463.AA ------------------------------------------------------------ Ddis_spnA.AA PNTSVSIPGLYSSDNDNTRLKNVNNNNNNNNNTTTY--------GSSTFPSSVISTTGSI Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA -------------------------------------------------------MYSDS Aque_g31493.t1.AA -----------PPSAPSTDKKPPPTEEANLGQSRKR--------SDHSPPLSNDAADSSV Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ISNEIPVDVRATANNDWVRVCSFVSETSTRGEPSNLNGSDKCIDLFGDLPPLESSESRGE Hsap_ILKAP.AA ------AAGKEAQKGPLLFDDLPPASSTDSGSGGPL--------LFDDLPPASSGDSGSL Spur_spur_hmm167846,hmm226318.AA ------VPVNQAPGGPI---QVGMGSSSVIGPDGKV--------YLKIIPQWRASQVSFN Spur_spur_hmm26051,hmm138463.AA ------EANLSKPNVTDVKVSANTQVDKKKEDANSL--------YQDEVRQEGGEEETGN Ddis_spnA.AA SNSIASAMDNDSSYSNESSPTSSMTLLPTTTTTTTTTTTTATTTDSTNNNNNNATVVIGK Mbre_mbre_36991.AA ---MAAPTANDEAAAKR------------------------------------------- Cele_F33A8.6.AA RKRSSDDLIDNSDESKK------------------------------------------- Aque_g31493.t1.AA KKVKVDGLCIETVTLSR------------------------------------------- Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------VTLSR------------------------------------------- Nvec_nvec_110119.AA KRKAEEISKDNVKKLAT------------------------------------------- Hsap_ILKAP.AA ATSISQMVKTEGKGAKR------------------------------------------- Spur_spur_hmm167846,hmm226318.AA KTLTIEDTRSNFTVVNKNHRLLFAILVGIDETVCPDCAYFRSRNNITVRAMPTPAPSTAH Spur_spur_hmm26051,hmm138463.AA LKRKSVDEQGDEVPAKR------------------------------------------- Ddis_spnA.AA GKPPKEPKPVKPPKEPKPPKEPKPPKEPKPPKEPKPIKEPKEKPVKESKPPKEPKPIKEP Mbre_mbre_36991.AA ------------------------------------------------------------ Cele_F33A8.6.AA ---------------------------------------------------------PKE Aque_g31493.t1.AA ------------------------------------------------------------ Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------------------ Nvec_nvec_110119.AA ------------------------------------------------------------ Hsap_ILKAP.AA -----------------------------------------------------KTSEEEK Spur_spur_hmm167846,hmm226318.AA STRPRDPEETSNTSGSPPHLAALTGALGVILGVILITVLITRTRRRSSLRPSEQSGDEKE Spur_spur_hmm26051,hmm138463.AA ------------------------------------------------------------ Ddis_spnA.AA KESKEPKEPKEPKPTKPPKEKKTSKVDGAAESKKNGADSCGNGGVGSKIKLES------- Mbre_mbre_36991.AA ----------------------------------------PKIQPSRFFA---------- Cele_F33A8.6.AA SR--------------------------------------------NLYCTLA------- Aque_g31493.t1.AA ------------------------------------------------YQLRG------- Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA ------------------------------------------------YQLRG------- Nvec_nvec_110119.AA --------------------------------------------GVKLYKLKG------- Hsap_ILKAP.AA NGSEELVEKKVCK------------------------------ASSVIFGLKG------- Spur_spur_hmm167846,hmm226318.AA TGGDTLERSPMLHRDDMPYDDCDSITGTGYINQWPPPLSSNSDYDNNLFGISNPSMIPPI Spur_spur_hmm26051,hmm138463.AA -------------------------------------------LATGMYSLHG------- Ddis_spnA.AA -----------------GFGSLQG-RRKN-----MEDTHVILNNLMGAVTYNGPPK---- Mbre_mbre_36991.AA -----------------GHAERRG-AREA-----IEDVCVVQEQLDL--QRQACAR---- Cele_F33A8.6.AA -----------------AYGCRKG-ERAD-----MQDTHIMLPKF----DLGTEKSF--- Aque_g31493.t1.AA -----------------YHGERKG-EREE-----MQDSHVIINNMME--QFPTLSNSP-- Aque_g5174.t1.AA ------------------------------------------------------------ Aque_g8870.t1.AA -----------------YHGERRG-EREE-----MQDSHVIINDMME--QFPTLSNSP-- Nvec_nvec_110119.AA -----------------FFAERKG-EREE-----MQDAHVIRDE-----YYPEPGRGDD- Hsap_ILKAP.AA -----------------YVAERKG-EREE-----MQDAHVILNDITE--ECRPPSSL--- Spur_spur_hmm167846,hmm226318.AA IHNEWEKSDGRLAQESELYADKIGYQRGDSISKVAVDVHSSMDPQTS--FKTGLPSIESP Spur_spur_hmm26051,hmm138463.AA -----------------YYAERKG-ERNE-----MQDKHVILNDFTP--QFSNLPST--- Ddis_spnA.AA --------------------DIPISYYAVYDGHGGTETSTLLEPTVHNCLV------NSQ Mbre_mbre_36991.AA --------------------ISSAAYFACFDGHAGRRAADHCAEHMLPHILAHLPSLSDF Cele_F33A8.6.AA --------------------LSRASFFAIFDGHAGPRAAEHCQSQMGKTVKEKLAKFSDF Aque_g31493.t1.AA --------------------VSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPK-EDV Aque_g5174.t1.AA -----------------------------------------------------FYS-EDV Aque_g8870.t1.AA --------------------VSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPK-EDV Nvec_nvec_110119.AA --------------------VQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPK-GSI Hsap_ILKAP.AA --------------------ITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPK-GDV Spur_spur_hmm167846,hmm226318.AA DSGVDSIYFEGTMEDGQTLFSSRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPK-TET Spur_spur_hmm26051,hmm138463.AA --------------------VSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPK-TET . Ddis_spnA.AA SFRD--GDYEQAFRDAYAEADDIVIEKCE------KSGSTGVSALLVGNKLYTANVGDSE Mbre_mbre_36991.AA GSKECATKIRKSLGQAFAAEDREFLALARAGQPQWKDGCTATVCLALNDVLFTANVGDAK Cele_F33A8.6.AA PTLT--KSLKQTFTESYKAVDDGFLAIAKQNKPIWKDGTTATTMIILNNVIYVANIGDSR Aque_g31493.t1.AA SA----QSIKRCLVDSFKKTDSDFLSLAAKATPSWKDGSTVAIIMAIDNVLYSGNLGDSK Aque_g5174.t1.AA SA----QSIKRCLVDSFKKTDSDFLSLAAKATPSWKDGSTVAIIMAIDNVLYSGNLGDSK Aque_g8870.t1.AA SA----QSIKRCLVDSFKKTDSDFLSLAAKATPSWKDGSTVAIIMAMDNVLYSGNLGDSK Nvec_nvec_110119.AA TGKD--KEIKKCLVDAYTLTDEQFLHEASKGTPVWKDGSTAVSVLVINNTLYVANLGDSK Hsap_ILKAP.AA ISVE--KTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSR Spur_spur_hmm167846,hmm226318.AA TNRD--KEIKKCLIETFRLTDEEFLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSK Spur_spur_hmm26051,hmm138463.AA TNRD--KEIKKCLIETFRVTDEEFLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSK . : ::: * .: . *.* * . : :.: :: .*:**: Ddis_spnA.AA IVLARAQPNANPKGPVT---------YEPVLLSYKHLAS--DD---------------QE Mbre_mbre_36991.AA AILVRYKEAPTVADTESVLPMLVDQDIATLVLTKDHNPV--VY---------------EE Cele_F33A8.6.AA AVVARKKEDGS---------------FAPVCLTVDHDPM--SH---------------DE Aque_g31493.t1.AA SVIYRRSGKGDTGGEPT---------VVSVPLTKDHTSAIGGK---------------EE Aque_g5174.t1.AA SVMYRRSGKGDTGGESA---------IVSVPLTKDHTSASVSYIFDYDFFIIFCFFQLEE Aque_g8870.t1.AA SVMYRRSDEGDTGGEPP---------VISVPLTKDHTSASVSYIFDYDFFIIFCFFQLEE Nvec_nvec_110119.AA ALVCRCDSAGK---------------ISVVRLSKDHSPT--GY---------------DE Hsap_ILKAP.AA AILCRYNEESQK--------------HAALSLSKEHNPT--QY---------------EE Spur_spur_hmm167846,hmm226318.AA AFLCRYNPETQK--------------HQFLPLSKDHTPT--DY---------------DE Spur_spur_hmm26051,hmm138463.AA AFLCRYNPETQK--------------HQFLPLSKDHTPT--DY---------------DE .: * . : *: .* . :* Ddis_spnA.AA KKRVTDLGGMIIFNRLFGSLAVSRSFGDKEYKEGEKKFCVSDPYQTTTDLTAR-DHFFIL Mbre_mbre_36991.AA RQRIQKAGGSVTDNRVQGVLGVSRSIGDGRYKHLG---VSSQPFTSKCTLDPNKDLFLVL Cele_F33A8.6.AA RMRIQKAGAVVKDGRINGVIEVSRSIGDLPFKSLG---IISTPDLKKLTLTKN-DLFAII Aque_g31493.t1.AA DRKI-------WEGRIMGIMEVSRSIGDGRFKGCG---LVATPHVSRCELTEN-DLFVVV Aque_g5174.t1.AA RKRIEKSGGFVREGRIMGIMEVSRSIGDGRFKGCG---LVATPHVSRCELTEN-DLFVVV Aque_g8870.t1.AA RKRIEKSGGFVREGRIMGIMEVSRSIGDGRFKGCG---LIATPHVSRCELTEN-DLFVVV Nvec_nvec_110119.AA RMRIQKAGGYVKDGRVLGVLEVSRSIGDGRFKRCG---VISTPDIMRCTLTDN-DRFLLL Hsap_ILKAP.AA RMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCG---VTSVPDIRRCQLTPN-DRFILL Spur_spur_hmm167846,hmm226318.AA RMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKRSG---VICTPDIKKCQLGDN-DRYVLL Spur_spur_hmm26051,hmm138463.AA RMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKRSG---VICTPDIKKCQLGDN-DRYILL .: .*: * : ****:** :* . * * . * : :: Ddis_spnA.AA ACDGLWDKVEYDEAVQFVQRNI-----------------KLGKSATEI-----SELLAQD Mbre_mbre_36991.AA ACDGLWGTLSASDVIQFCMKAFGEA------EQDDQLAGQPKLQATHV-----AARLANH Cele_F33A8.6.AA ACDGLWKSFSNLEAVSFAVEQLEAA-------KKTDIEQEPNESREAAELRVVAEKLAAE Aque_g31493.t1.AA ACDGLWNVFKMDEVAKFILGVVNDESIQKPGEDDRLIQGTEVIGDREYRFEVACNRLAVE Aque_g5174.t1.AA ACDGLWNVFKMDEVAKFILAVVNDESIQKPGEDDRLIQGTEVVSDREYRFEVACNRLAVE Aque_g8870.t1.AA ACDGLWNVFKMDEVAKFILGVVNDESIQKPGEDDRLIQGTEVVSDREYRFEVACNRLAVE Nvec_nvec_110119.AA ACDGLWKGFSVDEAVKYISKILDVR------YTYILTNEEPGLDPVEARFQLACDRIASD Hsap_ILKAP.AA ACDGLFKVFTPEEAVNFILSCLEDE----------KIQTREGKSAADARYEAACNRLANK Spur_spur_hmm167846,hmm226318.AA SCDGLWEGFDAEAVMQFTNDILDGE----------NVKQSEGKSKDDVLFETACNRLASE Spur_spur_hmm26051,hmm138463.AA SCDGLWEGFEADAVMQFTNDILDGE----------KVKQSEGKSKDDVLFETACNRLASE :****: . . .: . . :* Ddis_spnA.AA SYDRGSGDNITVLVVILNWN--- Mbre_mbre_36991.AA AVEKGASDNVSVLLVRFATKP-- Cele_F33A8.6.AA AVRRKCGDNVSVIIVKLELID-- Aque_g31493.t1.AA AVKRGCTDNVTVLIVDIIKNNNH Aque_g5174.t1.AA AVKRGCTDNVTVLIVDIIKNNDH Aque_g8870.t1.AA AVKRGCTDNVTVLIVDIIKNNNH Nvec_nvec_110119.AA AVRNGSSDNVTVML--------- Hsap_ILKAP.AA AVQRGSADNVTVMVVRIGH---- Spur_spur_hmm167846,hmm226318.AA AIRRGSSDNITVILVNIQKS--- Spur_spur_hmm26051,hmm138463.AA AIRRGSSDNITVIL--------- : . . **::*::