CLUSTAL W (1.81) multiple sequence alignment Nvec_nvec_s158.AA ------------------------------------------------------------ Cele_mtm-1.AA ------------------------------------------------------------ Nvec_nvec_s88.AA ------------------------------------------------------------ Aque_Aque_g20046.t1.AA ---------------------------------MAEGLSNRMSALSVQSEESNESRSTAR Aque_Aque_g3548.t1.AA ------------------------------------------------------------ Dmel_mtm.AA --------------------------------------------------------MDPS Nvec_Nvec_241000.AA ------------------------------------------------------------ Spur_Spur_hmm90253,hmm225577.AA MEANNGTDLPDDGSRQQRHVRQASATSVDGVNHGVPIPIPVIVNDQRQARAGNTGAASRR Hsap_MTM1.AA ------------------------------------------------------------ Hsap_MTMR1.AA --------------------MDRPAAAAAAGCEGGGGPNPGPAGGRRPPRAAGGATAGSR Hsap_MTMR2.AA ------------------------------------------MEKSSSCESLGSQPAAAR Nvec_nvec_s158.AA ------------------------------------------------------------ Cele_mtm-1.AA -------------------MDDRGNNSGEVGEFASSSMIQESI-------------DLKL Nvec_nvec_s88.AA ------------------------------------------------------------ Aque_Aque_g20046.t1.AA GTSSSPKPSPKASPILLRKDDVSSVGTGSEASPTTARRRELDV-LVEAQAHTSLPGDPPL Aque_Aque_g3548.t1.AA ------------------------------------------------------------ Dmel_mtm.AA ASLADKLASKTASSNSLDSSSKSSSLGSKHGG--GENGILRDT-------------PFGY Nvec_Nvec_241000.AA ------------MDGPKRQHSHNSKAEGGLGTVIEDGNVKAEL--------SANQGELAL Spur_Spur_hmm90253,hmm225577.AA APP----SANPAAEVPLQVTTLATSSGGSDTLKSQSGKGPRE-----ENSKLSQPEEIPL Hsap_MTM1.AA ------------MASASTSKYNSHSLENESIKRTSRDGVNRDL-----------TEAVPR Hsap_MTMR1.AA QPSVETLDSPTGSHVEWCKQLIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPL Hsap_MTMR2.AA PPSVDSLSSASTSHSENSVHTKSASVVSSDSISTSADNFSPDLRVLRESNKLAEMEEPPL Nvec_nvec_s158.AA ---------------------------------------------VVQFLIVVVL----- Cele_mtm-1.AA LAAESLIWTEKNVTYFGPL-GKFPGKIVITRYRMVFLVGDGG-KMYEQWKLDIPLGQVSR Nvec_nvec_s88.AA ------------------------------------------------------------ Aque_Aque_g20046.t1.AA LPGELLSYIEHKITYLDHFLGSIEGTVYITSYKMYFKSDPNPKNTEESVVLNVPLGVISH Aque_Aque_g3548.t1.AA ----------HKITYMDHFLGSIEGTVYISSYKMYFKSDPTPKNTEESVVLNVPLGVITH Dmel_mtm.AA LEGEEDQDQKNDVTYVCPYRGPVFGALTITNYRLYFRSLPL-RDQEPPVVVDVPLGVIAR Nvec_Nvec_241000.AA CKGEKPQATAKDVTYLCPFTGPVRGFLYITNYKLFFKA-----DDDIPFTVEVPLGTIYR Spur_Spur_hmm90253,hmm225577.AA LLGERIEGIAKDVTYLCPFIGPSRGTLTITNYKLYFKGG----DREPPFILDVPLGAVYR Hsap_MTM1.AA LPGETLI-TDKEVIYICPFNGPIKGRVYITNYRLYLRSL----ETDSSLILDVPLGVISR Hsap_MTMR1.AA FPGESIKAIVKDVMYICPFMGAVSGTLTVTDFKLYFKNV----ERDPHFILDVPLGVISR Hsap_MTMR2.AA LPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSM----ERDPPFVLDASLGVINR Nvec_nvec_s158.AA ------------------------------------------------------------ Cele_mtm-1.AA IEKVGRKTTSVAKRGDDN-YGFTIYCKDYRVYR--FTCNPASSDRKNVCDSLNRYAFPLS Nvec_nvec_s88.AA ------------------------------------------------------------ Aque_Aque_g20046.t1.AA VEKIGRSRQ----KGDNVIYGLDVHCKDMRTLRFAFAHNQESHGRRGMYDRLQIVAFPCS Aque_Aque_g3548.t1.AA VEKIGRSRQ----KGDNVIYGLDVHCKDMRTLRFAFAHNQESHGRRGMYDRLQIVAFPCS Dmel_mtm.AA VEKIGGATS----RGENS-YGIEIFCKDMRNLR--FAHKQQNHSRRTVFEKLQANAFPLS Nvec_Nvec_241000.AA VEKIGGTTS----RGENA-YGLEIYCKDFRNLR--FAHKQENHSRRLIYERIMHYAFPAS Spur_Spur_hmm90253,hmm225577.AA VEKVGGSTS----RGENS-YGLEVFCKDMRNLR--FAHKQENHSRRLVYEKVQTYAFPVS Hsap_MTM1.AA IEKMGGATS----RGENS-YGLDITCKDMRNLR--FALKQEGHSRRDMFEILTRYAFPLA Hsap_MTMR1.AA VEKIGAQS-----HGDNS-CGIEIVCKDMRNLR--LAYKQEEQSKLGIFENLNKHAFPLS Hsap_MTMR2.AA VEKIGGASS----RGENS-YGLETVCKDIRNLR--FAHKPEGRTRRSIFENLMKYAFPVS Nvec_nvec_s158.AA ----LFAIV-----------------------PLEVYLGHCLGSR--------------- Cele_mtm-1.AA HNLPMFASVHAAETPRLMKD------GWKIYSAEKEYERLGIPNS-RLWKEVDINKDYKF Nvec_nvec_s88.AA ------------------------------------------------------------ Aque_Aque_g20046.t1.AA YGKNVYAFHFRGDYP---DD------GWEVYDPEAELKRMGVGNDGVPWRICHLNKNYEL Aque_Aque_g3548.t1.AA YGKNVYAFHFRGDYP---DD------GWEVYDPEAELKRMGVGNDGVPWRICHLNKNYEL Dmel_mtm.AA YSGRLFAFAHAAANS---VNGNGGWDGWAVYEPLAELRRLGVPND--MWRATKLNESYAI Nvec_Nvec_241000.AA NGKPYFAYSFKDEFE---YN------GWDVYDAEKEFERLGLPTD--CWYVTRINEKYEL Spur_Spur_hmm90253,hmm225577.AA NKLPFFAFEYKEYYN---EN------GWAVFDPVAEYKRQGLPTE--SWRISRINENFTF Hsap_MTM1.AA HSLPLFAFLNEEKFN---VD------GWTVYNPVEEYRRQGLPNH--HWRITFINKCYEL Hsap_MTMR1.AA NGQALFAFSYKEKFP---IN------GWKVYDPVSEYKRQGLPNE--SWKISKINSNYEF Hsap_MTMR2.AA NNLPLFAFEYKEVFP---EN------GWKLYDPLLEYRRQGIPNE--SWRITKINERYEL Nvec_nvec_s158.AA ------------------------------------------------------------ Cele_mtm-1.AA SETYPRTFVIPTVSWEEGKPFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISG Nvec_nvec_s88.AA ------------------------------------------------------------ Aque_Aque_g20046.t1.AA CDTYTSTFSVPLNCSDE---MVQGVAQFRSKGRIPVLSWLHPVTQASITRCSQPLVGTMN Aque_Aque_g3548.t1.AA CDTYTSTFSVPLNCSDE---MVQGVAQFRSKGRIPVIQF--------------------- Dmel_mtm.AA CDSYPAVWAVPKAASDD---FLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSG Nvec_Nvec_241000.AA SDTYPAVVGVPSSVSDE---DIKKVAVFRSRNRLPVLCWLHPTNNASITRASQPNRGLLA Spur_Spur_hmm90253,hmm225577.AA CDTYPAVLAIPAAADDE---LLRQVAAFRSRNRLPIMSWLHPQSQATITRCSQPLVGVGG Hsap_MTM1.AA CDTYPALLVVPYRASDD---DLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSG Hsap_MTMR1.AA CDTYPAIIVVPTSVKDD---DLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPND Hsap_MTMR2.AA CDTYPALLVVPANIPDE---ELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSG Nvec_nvec_s158.AA ------------------------------------------------------------ Cele_mtm-1.AA KRSAEDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGYE--ENYVNAPLTFLNI Nvec_nvec_s88.AA ------------------------------------------------------------ Aque_Aque_g20046.t1.AA RRSKEDEQYMQEILKANDKSNKLYILDARPKINAMTNVAMGGGYEHEDCYVNMDFSFLDI Aque_Aque_g3548.t1.AA ------------------------------------------------------------ Dmel_mtm.AA KRNSDDEAYLSFIMEANAQSDKLTIMDARPSANAIANKAKGGGYESEDAYKNVEINFLDI Nvec_Nvec_241000.AA -RNKDDEKYFQAILEANPQCHKLLIFDARPRINAVANQAKGGGYETEENYQNTEVIFLDI Spur_Spur_hmm90253,hmm225577.AA KRSKEDEKYVQMILDANAQSHKLVIMDARPTVNAVANKAKGGGYENEDTYQNAEICFLDI Hsap_MTM1.AA KRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDI Hsap_MTMR1.AA KRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNKTKGGGYESESAYPNAELVFLEI Hsap_MTMR2.AA KRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDI Nvec_nvec_s158.AA ------------------------------------------------------------ Cele_mtm-1.AA HNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQSV Nvec_nvec_s88.AA ---------------------DDSKYLSQLEETEWLTQLSELLQTATQAAVAMDCDKSSV Aque_Aque_g20046.t1.AA GNIHVMRESLKKLREICYPDVDDQRWFSNLESSHWLDHIKAILCGAVKVVECVETHKSSV Aque_Aque_g3548.t1.AA ------------------------------------------------------------ Dmel_mtm.AA HNIHVMRESLRKVKEACFPTTDDSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMSTSV Nvec_Nvec_241000.AA ANIHVMRESLRKLKDICFPNIDDTHWLTNLENTKWLDHIKMIMAGAVRIADAVDRCRTSV Spur_Spur_hmm90253,hmm225577.AA HNIHVMRESLRKLKDICFPSIDEHHWLANLEATHWLEHVKMVLAGAVRIAERVEGQKTSV Hsap_MTM1.AA HNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSV Hsap_MTMR1.AA HNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTHWLEYIRMLLAGAVRIADKIESGKTSV Hsap_MTMR2.AA HNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSV Nvec_nvec_s158.AA -------------------------------FQSLVDREWIRGEHPFSNRCTKDGFSSTK Cele_mtm-1.AA LIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDN-YS Nvec_nvec_s88.AA LFSYEDGCDRTAQASCPKPI-------AIFSPQVLIQKEWLSFGHKFADRILPPETNPES Aque_Aque_g20046.t1.AA VVHCTDGWDRTAQITSLSMLMMDSYFRTIKGFEVLVEKEWLGCGHKFSQRTGHGDKN-HS Aque_Aque_g3548.t1.AA ------------------------------------------------------------ Dmel_mtm.AA VVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGHGDNK-HS Nvec_Nvec_241000.AA VVHCSDGWDRTPQLTALAMLLMDPYYRTIIGFEVLIEKEWLSFGHKFNQRYGHGDKN-HA Spur_Spur_hmm90253,hmm225577.AA VVHCSDGWDRTAQLTALAMLLLDPYYRTIRGFEVLIEKEWLACGHKMAQRHGHGDKN-YT Hsap_MTM1.AA LVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKN-HT Hsap_MTMR1.AA VVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKEWISFGHRFALRVGHGNDN-HA Hsap_MTMR2.AA VVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKN-HA Nvec_nvec_s158.AA YKGQGPVFLLFLDCVWQIYQQFPCSFEF-------------------------------- Cele_mtm-1.AA DGERSPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLYNSEKIRLKDK Nvec_nvec_s88.AA TEEHGPVFLQWLDCVWQLTQQYPFSFQFNEYLLKTIAESAYSSRFGTFLANSSRDREEE- Aque_Aque_g20046.t1.AA DDQRSPIFLQFIDCVWQLMEQFPTAFEFNEHFLITILDHLYSCLFGTFLFNCERLRVEA- Aque_Aque_g3548.t1.AA ------------------------------------------------------------ Dmel_mtm.AA DADRSPVFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAE- Nvec_Nvec_241000.AA DDQRSPVFLQFIDCVWQVTRQFPCAFEFNETFLITILDHLYSCMFGTFLYNSESQREKE- Spur_Spur_hmm90253,hmm225577.AA DADRSPIFQQFIDCVWQVTRQFPNAFEFNEHFLITILDHLYSCLFGTFLFNCERERVKE- Hsap_MTM1.AA DADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQ- Hsap_MTMR1.AA DADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRFKE- Hsap_MTMR2.AA DADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKE- Nvec_nvec_s158.AA ------------------------------------------------------------ Cele_mtm-1.AA KCDETTISFWSYVL----ENKKKFRNPMFKHGKS--NKVINVNPSLCGLHVWIDYYARSN Nvec_nvec_s88.AA EIDERTASLWTWLNVVTMDDPDCFINPRY------------------------------- Aque_Aque_g20046.t1.AA GVKDKTVSLWSFVN----SQIDVYKNPLYAELMN--NKVLFPRTSIRILKLWTGYYMRWN Aque_Aque_g3548.t1.AA ------------------------------------------------------------ Dmel_mtm.AA DLKHKTTSLWTHIN----SSLDQYLNPLFPSFTHGAELVLRPIASVRSVRLWKGLYCRWN Nvec_Nvec_241000.AA DVKTRTTSLWSYIN----TSMMEFKNPLYAPYLH--QHVLFPVPSLRRLELWTRYYIRWN Spur_Spur_hmm90253,hmm225577.AA QVKTKTVSLWSYIN----SSMEEFINPMYASYMH--QHVLFPVASMRRIELWTSYYIRWN Hsap_MTM1.AA KVTERTVSLWSLIN----SNKEKFKNPFYTKEIN---RVLYPVASMRHLELWVNYYIRWN Hsap_MTMR1.AA DVYTKTISLWSYIN----SQLDEFSNPFFVNYEN---HVLYPVASLSHLELWVNYYVRWN Hsap_MTMR2.AA NLPKRTVSLWSYIN----SQLEDFTNPLYGSYSN---HVLYPVASMRHLELWVGYYIRWN Nvec_nvec_s158.AA ------------------------------------------------------------ Cele_mtm-1.AA PYVVTPNHEDVQQPGAQFVDEKKQLLDEIMALDDAAQKLTA------------------- Nvec_nvec_s88.AA ------------------------------------------------------------ Aque_Aque_g20046.t1.AA PRMKPQE--SEFERSRQLQILIKLLKEKCQELTEQQRNITAAVLNSDGSTQPS------- Aque_Aque_g3548.t1.AA ------------------------------------------------------------ Dmel_mtm.AA PGLCAPQ--HGCQRTRELLSKQDQLFKLVNELRLKSNNR-------SNSMQTTTRLASPM Nvec_Nvec_241000.AA PRMQAQE--SEEQRNRDLFFLCEQLRQKCEELQQEIDQR--MTVEVPSTPDAVSLHSTNS Spur_Spur_hmm90253,hmm225577.AA PRMKPQE--PVHQRNKELLELRTQLQRQVEELQKEIEARDLGLQSTPGGTASPPKITSPV Hsap_MTM1.AA PRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAK---LSDPPTSPSSPSQMMPHV Hsap_MTMR1.AA PRMRPQM--PIHQNLKELLAVRAELQKRVEGLQREVATR--AVSSSSERGSSPSHSATSV Hsap_MTMR2.AA PRMKPQE--PIHNRYKELLAKRAELQKKVEELQREISNR---STSSSERASSPAQCVTPV Nvec_nvec_s158.AA --------- Cele_mtm-1.AA --------- Nvec_nvec_s88.AA --------- Aque_Aque_g20046.t1.AA --------- Aque_Aque_g3548.t1.AA --------- Dmel_mtm.AA H-------- Nvec_Nvec_241000.AA NSQWATAQL Spur_Spur_hmm90253,hmm225577.AA NA------- Hsap_MTM1.AA QTHF----- Hsap_MTMR1.AA HTSV----- Hsap_MTMR2.AA QTVV-----