CLUSTAL W (1.81) multiple sequence alignment Mbre_Mbre_26246.AA ------------MDEIEPIKINNVSL--RQN-NRTVATGVLKFQHAVMLFHDAAS--GTE Cele_mtm-6.AA ----------MRFEDIGISKVDKVCLVDRLG-CQENLVGTVHVTTTHIIFRAENG--SKE Aque_Aque_g23749.t1.AA -----------MDSRIKTPKVERVLLYQRHR-RREYVTGTLCLTDRHLIFIEPTG--LME Hsap_MTMR8.AA ------------MDHITVPKVENVKLVDRYV-SKKPANGILYLTATHLIYVEASGAARKE Hsap_MTMR7.AA ------------MEHIRTPKVENVRLVDRVS-PKKAALGTLYLTATHVIFVENSPDPRKE Hsap_MTMR6.AA ------------MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSH---QKE Dmel_CG3530.AA ------------MDEIKLAKVENVRMIDRYN-TKNPTVGTLYLTATHLIFVEPDS--NKE Nvec_Nvec_235730.AA --------MAQIMDIIQTAKVDQVRLKTRF--SKKVSRGTLYLTPTHLIFVDPVG--AKE Spur_Spur_hmm242189,hmm82360.AA MPKRRTSRSSSVMEYITTPKIENVRLLDRFN-SRKPSSGTLYLTATHLIFVDPAG--KKE . * *::.* : * . * : . ::: * Mbre_Mbre_26246.AA QWIEYMIIQTVDMVKLGPT-WILNIFCKNFRKIEFQMTSEDDCLRAHDRLQELSLPEDLE Cele_mtm-6.AA LWLATGLISSVEKGTLTAAGCMLVIRCKHFQVITLLISRDKSCQDLYETLQRAAKPVNVT Aque_Aque_g23749.t1.AA TWVLYHHIHSVERQSLTTKGYPLVIETKTFRQLFMIIPRESDCHDIMDTIASFSRPDTYR Hsap_MTMR8.AA TWIALHHIATVEKLPITSLGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPE Hsap_MTMR7.AA TWILHSQISTIEKQATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYE Hsap_MTMR6.AA TWILHHHIASVEKLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYE Dmel_CG3530.AA TWILHMHVASIEKLPLSTTGSPLLIRCKTFLSVTFVIPKDSECHDVYTSLLKLFQPVSIN Nvec_Nvec_235730.AA TWILHSHILSLEKLPLNAAGSPLRIRCKTFQNATLIIPKEKECHDIYTALLFFSNREKLE Spur_Spur_hmm242189,hmm82360.AA TWILHMHIGFVEKLPLTTGGAPLQIRCKTFQAATFVIPREKDCQEMYKSLQKLSNPAELE *: : :: . * : * * : : : * : Mbre_Mbre_26246.AA QLDAFR--PQRKIDSDVDGWALYSPMAEYGRMGVPNPQWQQVDYNNTYNLCPTYGRTLYL Cele_mtm-6.AA ELLAFE---NREPVEDVRGWRRLDWNSEMTRQGITKSQWTESNINEGYTICDTYPNKLWF Aque_Aque_g23749.t1.AA ELYAFQFTPSSDGFVKSSGWNLYDSVVEYGRMGVPNEHWVCTELNKDYELCETYSNTLFV Hsap_MTMR8.AA DLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVV Hsap_MTMR7.AA ELYCFSFNPMLDKEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYV Hsap_MTMR6.AA DLYAFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYV Dmel_CG3530.AA KLYCFNYQPNKDDFPKNAGWDYFKLEAEFKHMLVPNEAWTLCSMNEKYELCDTYPRQIYV Nvec_Nvec_235730.AA DLYAFSYSPQTEKLTQSAGWALFDIKSDYTRMGVPSDLWTATQLNKDYELCDTYPNILYV Spur_Spur_hmm242189,hmm82360.AA DLYAFHYKSATVVPTMVTGWDQFDLQAEYARMGIPNAHWCSTAINKNYEICDTYSRTLYV .* .* ** . : . :.. * * * :* :* : . Mbre_Mbre_26246.AA PSSVTMEQAFASAKFRSKQRLPVLSYLFQRNQAAICRCAQPLTGVQAKRSEDDEALLEFI Cele_mtm-6.AA PTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLTGFSA-RCVEDEKLMELV Aque_Aque_g23749.t1.AA PAKAEKSVVLGSAKFRSKGRLPVLSYYCQAKNSALCRSSQPLTYITR-RSQEDEAMIQAI Hsap_MTMR8.AA PKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYT-RCVDDELLLEAI Hsap_MTMR7.AA PKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSA-RCLEDEQMLQAI Hsap_MTMR6.AA PRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSA-RCLEDEHLLQAI Dmel_CG3530.AA PKEATTLMLISSSRFRSKGRLPVLTYLH-NNKASICRCSQPLSGFSA-RCLEDEQMLEAI Nvec_Nvec_235730.AA PKSATKEVLVGSSRFRSRGRLPVLSFYHKSTQAAVCRCSQPLGGFKG-RCPEDEQMIQAL Spur_Spur_hmm242189,hmm82360.AA PTHASPPVLVGSSRFRSRGRLPVLSYLHQENN-------KRLRG----RVTFD------- * . ..*..***. *.***:: . : * * * Mbre_Mbre_26246.AA RLCNPHSELPLIIVDTRPRMNAMANKAAGK-GFENMEGYTNCRLEFHGIENIHTMRGSLN Cele_mtm-6.AA GKANTNSDN-LFLVDTRPRVNAMVNKVQGK-GFEDERNYSNMRFHFFDIENIHVMRASQA Aque_Aque_g23749.t1.AA IDANPNSSS-LHLLDSRPKINAVANKAAHKGGYETTDNYPNIVYQFNNIQNIHVMRESLQ Hsap_MTMR8.AA SQTNPGSQF-MYVVDTRPKLNAMANRAAGK-GYENEDNYANIRFRFMGIENIHVMRSSLQ Hsap_MTMR7.AA RKANPGSDF-VYVVDTRPKLNAMANRAAGK-GYENEDNYSNIKFQFIGIENIHVMRNSLQ Hsap_MTMR6.AA SKANPVNRY-MYVMDTRPKLNAMANRAAGK-GYENEDNYSNIRFQFVGIENIHVMRSSLQ Dmel_CG3530.AA RKTNSNTDY-MYVVDTRPRINAMANRAAGK-GYENEAFYENIKFHFLGIENIHVQRASLQ Nvec_Nvec_235730.AA LNSNPNSKF-IYIVDTRPRLNALANRAAGK-GYESEDFYENVKFQFVGIENIHVMRQSLF Spur_Spur_hmm242189,hmm82360.AA VNQNLALEI-L-----RPL---------------SDNF---------------------- * : ** Mbre_Mbre_26246.AA ALVKAS--KRNSPC--HDHQIGIQECAWLKHIQAVLKTTMVITRYI-QDGHSVLVHCSDG Cele_mtm-6.AA RLLDAV---TKCRD-VTEYWKTLEASGWLKHVRSVVECSLFLAESI-SRGTSCVVHCSDG Aque_Aque_g23749.t1.AA KLLE----ALHSPAGVSSVLQGLDASSWLRHIHLVLEAGAFIAKALYTEGINVLVHCSDG Hsap_MTMR8.AA KLLEVC--ELKTPT-MSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDG Hsap_MTMR7.AA KMLEVC--ELKSPS-MSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDG Hsap_MTMR6.AA KLLEVN--GTKGLS-VNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDG Dmel_CG3530.AA KVLEAC--EQKSPT-MSAFINALESSGWLKHIRSILDTSSFIANAV-DKGVSVVVHCSDG Nvec_Nvec_235730.AA KMLEVVGESPKTPA--GAFYSGLEASNWLKHIKNILDTSVFIAKAVAMEKASVLVHCSDG Spur_Spur_hmm242189,hmm82360.AA --------SLKNPS-MEAFLSGLESSQWMKHIKAVLDTSLFIAKAIADEGLSVLVHCSDG : :: . *:.*:. ::. .:: : . :****** Mbre_Mbre_26246.AA WDRTAQTCSLAGLMLDPYYRTIEGYIVLIEKEWLSFGHKFLDRNGFL----KGSGREVSP Cele_mtm-6.AA WDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDRCGHVGALNDEAGKEVSP Aque_Aque_g23749.t1.AA WDRTAQTCSLASLMIDKYYRTIHGFMILIEKEWLSFGHKFTIRSGHI----NSDSKEVSP Hsap_MTMR8.AA WDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHL----DGDSKEVSP Hsap_MTMR7.AA WDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNL----DGDPKEISP Hsap_MTMR6.AA WDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQL----DGDPKEVSP Dmel_CG3530.AA WDRTAQVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHI----QTDAREVSP Nvec_Nvec_235730.AA WDRTAQTCSLASIILDPYYRTIHGFQVLIEKEWLSFGHKFTDRCGLL----QSDQKEFSP Spur_Spur_hmm242189,hmm82360.AA WDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRCGLL----AYDPREVSP ****:*. :: :::: .***: * ****:*:.:**** * * : .*.** Mbre_Mbre_26246.AA IFLQLLECTWCLQRQFPLAFEFNESFLIAMHDCLHSCKFGTFLGNCEQARRDAKLHERTQ Cele_mtm-6.AA IFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDLNLSKRTK Aque_Aque_g23749.t1.AA IFTQFLDAVWQIMVQFPKSFEFNELFLLTIHDHLFSCQFGTFLGNNERDRKINKFSEKTY Hsap_MTMR8.AA IFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTH Hsap_MTMR7.AA VIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTY Hsap_MTMR6.AA VFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTY Dmel_CG3530.AA IFTQFLDCTWQLMSQRSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTF Nvec_Nvec_235730.AA VFLQFLESIWQLLQQFPFSFQFNERFLLTLHDHVYSCQFGTFLGNCQKERRDLGLPKRTY Spur_Spur_hmm242189,hmm82360.AA VFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTF :: * ::. * : * . :*:*.* :*: :: :.*.:**.*: * :. * . :.* Mbre_Mbre_26246.AA SAWSYLYSRKSEFINPFYDASQDPEGGVLNPSLAP--QHFELWSAMYCRWESASLPRQPL Cele_mtm-6.AA SLWTWMDARHDDYMNPFYSPTAHVA--LLDLDTRA--ARFTVWTAMYNRFDNGLQPRERL Aque_Aque_g23749.t1.AA SLWGYIWSRLDDFTNPLFDNDTENY---IMPKTEV--SILSLWRGLYCCYETGPHPQELM Hsap_MTMR8.AA SVWPFLVQRKPDFRNPLYKGFT--MYGVLNPSTVP--YNIQFWCGMYNRFDKGLQPKQSM Hsap_MTMR7.AA SLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSV Hsap_MTMR6.AA SLWPFLLEDQKKYLNPLYSSESHRF-TVLEPNTVS--FNFKFWRNMYHQFDRTLHPRQSV Dmel_CG3530.AA SLWGYMANHLNEYINPLYKPNVDEA---IKANLAP--QCIKFWRGMYSRFESGIHPREPL Nvec_Nvec_235730.AA SLWGYMWQNISDYANPLYREVTQDD--ALWPDTSP--QAIRFWRAMYNRYDNEVHPRETL Spur_Spur_hmm242189,hmm82360.AA SLWQYMQARMSDYINPLYKANHPSANGILKPNFSP--QMLKFWRGMYNRYENGVHPRESV * * : .: **:: : .* :* :: *.: : Mbre_Mbre_26246.AA LRSFEYYKVKLDHDKRRLAEAKARLSPAAASTETNPSTEDPIPSPLEVVEVEVEVEVEVE Cele_mtm-6.AA EDLT-----------------------------------------MAAMEHVGVLESHVA Aque_Aque_g23749.t1.AA EEVA-----------------------------------------GSLRQQNVCIQDHIK Hsap_MTMR8.AA LESL-----------------------------------------LEIKKQRAMLETDVH Hsap_MTMR7.AA TDYL-----------------------------------------MAVKEETQQLEEELE Hsap_MTMR6.AA FNII-----------------------------------------MNMNEQNKQLEKDIK Dmel_CG3530.AA GDVL-----------------------------------------LDSKEHCNSLEDHVQ Nvec_Nvec_235730.AA LDST-----------------------------------------SSIIDHNDSLQDHVK Spur_Spur_hmm242189,hmm82360.AA TDVL-----------------------------------------SAMKDHSTSLADHVQ . : : Mbre_Mbre_26246.AA VEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVEVVELEV Cele_mtm-6.AA ---QLRTRL---AELKTQQNQQITSTNTPTNMVD----------SGMS------------ Aque_Aque_g23749.t1.AA ---YLEQHR---DSLEKQIKEYQECLSLCSSTTS----------TSED------------ Hsap_MTMR8.AA ---ELEKKLKVRDEPPEEICTCSQLGNILSQHLG----------SPLTNPLGFMGINGDL Hsap_MTMR7.AA ---ALEERLEKIQKVQLNCTKVKSKQSEPSKHSG----------FSTS------------ Hsap_MTMR6.AA ---DLESKIKQRKNKQT------------------------------------------- Dmel_CG3530.AA ---HLTKRI---ASFKNYISKSAKKLQDATSAPGKVNKELSSNEINDN------------ Nvec_Nvec_235730.AA ---LLAKNV---QNLSEDLSAENNGQKELS--------------LSDN------------ Spur_Spur_hmm242189,hmm82360.AA ---FLENQI---SSLKRMLASESVSREE----------------KPDT------------ : . Mbre_Mbre_26246.AA EVLLELELEVEVEVEVEVEVEVLLELEVEVEVEVEVEVEVEVLLELELELEVDVEVEVLL Cele_mtm-6.AA SATDDLKN-------------------------------------LSLSHPLDPLSSTLP Aque_Aque_g23749.t1.AA VFTDESKD-------------------------------------PSSSEPDGRAPLKGC Hsap_MTMR8.AA NTLMENGT-------------------------------------LSREGGLRAQMDQVK Hsap_MTMR7.AA DNSIANTP-------------------------------------QDYSGNMKSFPSRSP Hsap_MTMR6.AA DGILTKEL-------------------------------------LHSVHPESPNLKTSL Dmel_CG3530.AA KYNYDKKL-------------------------------------SELSAADDDHPLKAS Nvec_Nvec_235730.AA DTINESIS-------------------------------------VVAKEGETQNPSLCE Spur_Spur_hmm242189,hmm82360.AA NHIFENGS-------------------------------------TQNSNSLDKDTTIST Mbre_Mbre_26246.AA ELELELELEVEVEVEVEVEVLLELELELELEVEVEVEVEVEVEVEVEVEVEVEVEVEVEV Cele_mtm-6.AA ILERATSQESGVMDSSLYYPDEALT----------------------------------- Aque_Aque_g23749.t1.AA NEKLRLESLNL------RSLLLHVP----------------------------------- Hsap_MTMR8.AA SQGADLHHNCCEIVGSLRAINI-------------------------------------- Hsap_MTMR7.AA SQGDE------------------------------------------------------- Hsap_MTMR6.AA CFKEQT------------------------------------------------------ Dmel_CG3530.AA NMSFASLSLSAEQSSPPQALPEEIN----------------------------------- Nvec_Nvec_235730.AA DEHLQKALKRYCLTM--DDLLMELP----------------------------------- Spur_Spur_hmm242189,hmm82360.AA KDDISNEVLSASLMNNAVE----------------------------------------- Mbre_Mbre_26246.AA EVEVEVEVEVEVEVEVEVEVEVEVEVEVLLELELELELEVEVEVEVEVEVEVEVEVEVEV Cele_mtm-6.AA ------------------------------------------------------------ Aque_Aque_g23749.t1.AA ------------------------------------------------------------ Hsap_MTMR8.AA ------------------------------------------------------------ Hsap_MTMR7.AA ------------------------------------------------------------ Hsap_MTMR6.AA ------------------------------------------------------------ Dmel_CG3530.AA ------------------------------------------------------------ Nvec_Nvec_235730.AA ------------------------------------------------------------ Spur_Spur_hmm242189,hmm82360.AA ------------------------------------------------------------ Mbre_Mbre_26246.AA EVEVEVLLELELELEVEVEVELEVEVLLELELEVEVEVEVEVEVEVLLELEVEVEVEVEV Cele_mtm-6.AA --------------------------------------KYSLKWQPLRGADRCSNPACRG Aque_Aque_g23749.t1.AA --------------------------------------EINLPWTPLRVASQCG-CGSAF Hsap_MTMR8.AA --------------------------------------SGDVGISEAMGISGDM-CTFEA Hsap_MTMR7.AA --------------------------------------------DSALILTQDNLKSSDP Hsap_MTMR6.AA -------------------------------------------LLPVNDALRTIEGSSPA Dmel_CG3530.AA --------------------------------------SVAVDWKPMRNVTTCS-CSTPF Nvec_Nvec_235730.AA --------------------------------------PIAIKWKSVRDVSQCSTCSLPI Spur_Spur_hmm242189,hmm82360.AA --------------------------------------SVATEWQSFRHIRQCS-CSSPF Mbre_Mbre_26246.AA EVEVEVLLELELELEVDVEVEVLLELELELELEVEVEVEVEVEVEVEVEVDEEDEVEVDE Cele_mtm-6.AA EFSSTIERRIHCHLCGMIFCRRCLKV------------------SADERERVCDKCKTD- Aque_Aque_g23749.t1.AA TFSK---RKYHCSYCGTVVCSTCGSYHAPLRYLA----------TSTTSHRVCKSCSKMS Hsap_MTMR8.AA TGFS---KDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSK Hsap_MTMR7.AA DLSA---NSDQESGVEDLSCRSPSGGEHAPSE------------DSGKDRDSDEAVFLTA Hsap_MTMR6.AA D------NRYSEY-AEEFSKSEPAVVSL----------------EYGVARMTC------- Dmel_CG3530.AA DQFS---KKTHCWRCGDIFCERCIDKNVALPGH-----------DSGKPVPVCRGCFRQM Nvec_Nvec_235730.AA AFLS---RKYHCWNCGEVFCRRCIERQCSLPAH-----------YSENTVPVCKQCYKRI Spur_Spur_hmm242189,hmm82360.AA DYFS---RKYHCWKCGEVFCIRCIDKQTQLPGH-----------ESQRPVPVCRPCYRE- . Mbre_Mbre_26246.AA EVTGRGSWFALRRMEQSRSSKRSASAFFKHFFNFLASYEQE Cele_mtm-6.AA ----------------------------------------- Aque_Aque_g23749.t1.AA NISDQQFNFLFLKK--------------------------- Hsap_MTMR8.AA HQ--------------------------------------- Hsap_MTMR7.AA ----------------------------------------- Hsap_MTMR6.AA ----------------------------------------- Dmel_CG3530.AA QKQSP------------------------------------ Nvec_Nvec_235730.AA QHNEI------------------------------------ Spur_Spur_hmm242189,hmm82360.AA -----------------------------------------