CLUSTAL W (1.81) multiple sequence alignment Cele_Y41D4A.5.AA MSDDTSASVWNDGGPPEIQEQKPKSPPPPLPTSNPVVKDTPNVVPTGDLIQFESEEERAA Mbre_Mbre_25202.AA --------------------------------------------------MRKSDQQDAL Hsap_PTPN18.AA ----------------------------------------------------MSRSLDSA Hsap_PTPN12.AA -----------------------------------------------------MEQVEIL Hsap_PTPN22.AA -----------------------------------------------------MDQREIL Spur_Spur_PTPN12.AA -----------------------------------------------------MSLKENL Aque_Aque_g32534.t1.AA ------------------------------------------------MAELDSDFTLKL Nvec_Nvec_PTPN12.AA -----------------------------------------------------------M Cele_Y41D4A.5.AA TTVPNGNPVIFEKNPAMDGLLREFLKEEEAYTPQDYLRRFYQIRVEQEKLRMEAEYRSEC Mbre_Mbre_25202.AA ---------------------------------EGFGAEFQRLRDMTAAYKAST--SREE Hsap_PTPN18.AA RSFLERL----EARGGREG--------------AVLAGEFSDIQACSAAWKADGVCSTVA Hsap_PTPN12.AA RKFIQRVQAMKSPDHN--G-------------EDNFARDFMRLRRLSTKYRTEKIYPTAT Hsap_PTPN22.AA QKFLD------EAQSKKIT-------------KEEFANEFLKLKRQSTKYKADKTYPTTV Spur_Spur_PTPN12.AA ENFLEHYENMADLSSSLDG-------------SDSFELEFNHLKQISQRYRTEKVYPTSA Aque_Aque_g32534.t1.AA NEFLDHFMSLAEDNEEND---------------ATFNKEFQALKMESQRYKDQNTFPAES Nvec_Nvec_PTPN12.AA QRFLQHKSSL-EPRNNPQG-------------ENGFAKEFQELKNISSRQKRDKAFSTNH * :. . . Cele_Y41D4A.5.AA AVAPQHYARNRYRDILPYDKNRVEIQKDSENP-----EGYMNASLIQLPGGKTEFIAAQA Mbre_Mbre_25202.AA GTTMHTKRKNRYKDIIPYDFNRVVLTTQRSEDEDISGSDYINASSVEHGESQCRFIASQG Hsap_PTPN18.AA GSRPENVRKNRYKDVLPYDQTRVILSLLQEEG----HSDYINGNFIRGVDGSLAYIATQG Hsap_PTPN12.AA GEKEENVKKNRYKDILPFDHSRVKLTLKTPSQ----DSDYINANFIKGVYGPKAYVATQG Hsap_PTPN22.AA AEKPKNIKKNRYKDILPYDYSRVELSLITSDE----DSSYINANFIKGVYGPKAYIATQG Spur_Spur_PTPN12.AA GESDVNMRKNRYKDILPFDHSRYLLSQIDNVE----GSDYVNANFLKGAANDHTYLAAQG Aque_Aque_g32534.t1.AA GQNPVNKKKNRFKDILPFEYTRVQLHKIEGVE----GSDYINANYIQGPDGNVEYIAAQG Nvec_Nvec_PTPN12.AA GEKEYNRTKNRYKDILPYDYSRIVLPEIKGVD----GSDYINGNYIKGPTKNIMYLAAQG . .**:.*::*:: .* : ..*:*.. : ::*:*. Cele_Y41D4A.5.AA PLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEEEK Mbre_Mbre_25202.AA PLPHTLDDFWRMLWEKDVRIVVMACNIFENDRFKCAKYWPN-LHEFDVFDEFEVDNMAED Hsap_PTPN18.AA PLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQ-EQEPLQTGLFCITLIKEK Hsap_PTPN12.AA PLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQ Hsap_PTPN22.AA PLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEK Spur_Spur_PTPN12.AA PLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-EGEEHCFGDILVTQIGQQ Aque_Aque_g32534.t1.AA PLPHTVNDFWRMIWYHQIEIVIMACREVEMAKPKCQCYWPQ-VGESAMYGAIQVTTDHEE Nvec_Nvec_PTPN12.AA PLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEE **. *: ::*.:: :::: * * . .* ** : :. Cele_Y41D4A.5.AA LFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVS Mbre_Mbre_25202.AA AIDQD-FLVRTLKVTHK--GASRIIYQYHYHAWPDHGVPARPGSVMRLIAAFRERQP--- Hsap_PTPN18.AA WLNED-IMLRTLKVTFQ--KESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQG--- Hsap_PTPN12.AA ART-D-YFIRTLLLEFQ--NESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQE--- Hsap_PTPN22.AA RKS-D-YIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQE--- Spur_Spur_PTPN12.AA RVTKD-FMIRTLKATRD--KEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQT--- Aque_Aque_g32534.t1.AA NVSND-FIIRQLTAECQ--GEKQVIRQFHYTAWPDHGRPESATPIIRMIEMFREHRK--- Nvec_Nvec_PTPN12.AA AMGDG-FTVRTLAVQAG--KTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVG--- . :* * . . * :* ***.. * :: : Cele_Y41D4A.5.AA PQDSSPILVHCSAGVGRT-----GTIIAINFIREQMKA-ETL-HSIDIFGLVMTLRKQRA Mbre_Mbre_25202.AA SDQAAPLVIHCSAGVGRTGHFLLGTICAIDIVWSMLKQMGLDAPCFDIFQVVWFLRQHRP Hsap_PTPN18.AA -SGPEPLCVHCSAGCGRT-----GVLCTVDYVRQLLLT-QMIPPDFSLFDVVLKMRKQRP Hsap_PTPN12.AA -HEDVPICIHCSAGCGRT-----GAICAIDYTWNLLKA-GKIPEEFNVFNLIQEMRTQRH Hsap_PTPN22.AA -DDSVPICIHCSAGCGRT-----GVICAIDYTWMLLKD-GIIPENFSVFSLIREMRTQRP Spur_Spur_PTPN12.AA -AEEPPIVVHCSAGCGRT-----GTICVIDYVRNALQL-EKIDQNFSLYDIIVDMRKQRH Aque_Aque_g32534.t1.AA -RHDIPFAIHCSAGCGRT-----GTIIAIDFARTMLIK-KTIPDKLDVFSIVQQMRKQRP Nvec_Nvec_PTPN12.AA -SQDTPVLVHCSAGCGRT-----GTICALDYARTLLQT-GRT-EELSVFDIVANLRRQRV *. :***** *** *.: .:: . : :.:: :: :* :* Cele_Y41D4A.5.AA SMVQTQDQFQFVHRCIASYCRRHLGIIEEP------------------------------ Mbre_Mbre_25202.AA AMVQTEDQYVFVYKAILDLVQQVLASMDNSAL---------------------------- Hsap_PTPN18.AA AAVQTEEQYRFLYHTVAQMFCSTLQNASPH------------------------------ Hsap_PTPN12.AA SAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSP- Hsap_PTPN22.AA SLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPK Spur_Spur_PTPN12.AA AIVQTRNQYELVHRAVVDMFQAHLGIKPEDYGHNYEN--------VQLKHEHFEQPRMP- Aque_Aque_g32534.t1.AA AMVQALDQYVFVYMAIVELVQQSLT--------------------NV--------PQLP- Nvec_Nvec_PTPN12.AA AMVQTKEQYTLVYKAVEELVNEELRKQNHL------------------------------ : **: :*: ::: : . : Cele_Y41D4A.5.AA ------------------------------------------------------------ Mbre_Mbre_25202.AA ------------------------------------------------------------ Hsap_PTPN18.AA ------------------------------------------------------------ Hsap_PTPN12.AA -----PPKPPRTRSCLVEGDAKE------EILQPPEPHPVPPILTPSPPSAFPTVTTVWQ Hsap_PTPN22.AA STTKAAKMMNQQRTKMEIKESSSFDFRTSEISAKEELVLHPAKSSTSFDFL-ELNYSFDK Spur_Spur_PTPN12.AA -----PKVPGQSGAAADKRDSSSHNYVNCNVTPKGVSVDSPELPMPKLPSGPPKSSRGSD Aque_Aque_g32534.t1.AA -----PRMLNFEKA--------------------------------------PVESPVPT Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA -----------------------------------KLDLAPPVATADLPVGSSGSVRLIA Mbre_Mbre_25202.AA -----------------------------------LPKSTAPVAMESVYDSVTPAPEAIV Hsap_PTPN18.AA ----------------------YQN----------IKENCAPLYDDALFLRTPQALLAIP Hsap_PTPN12.AA DNDR------------------YHPKPVLHM----VSSEQHSADLNRNYSKSTELPGKNE Hsap_PTPN22.AA NADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSKVPITRTKS Spur_Spur_PTPN12.AA SPDGSI----------------YANCDVGAT----SGDSGKPSKDASHPSSSKQTSQAKP Aque_Aque_g32534.t1.AA NTDDAV----------------YQNITSLNN--EGSSESDHPVPMARTFSGSTTSGSDGN Nvec_Nvec_PTPN12.AA ----------------------YVNVS--------VGDQQGGEEQNYENSTSSASSEDQD . Cele_Y41D4A.5.AA PPTP-------------------------TTGPSTDQTATIANYNQLHHHQSSSNH---- Mbre_Mbre_25202.AA KIAE-----------------------PVYINPAMVQACTSSVPKERLRRLSMIRV---- Hsap_PTPN18.AA RPPG--------------------GVLRSISVPGSPGHAMADTYAVVQKRGAPAGA---- Hsap_PTPN12.AA STIE----QID--------KKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSAS Hsap_PTPN22.AA TPFELIQQRET--------KEVDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNYSL Spur_Spur_PTPN12.AA RPSPDDRFKSNFKATLSAFKDIEFDVGGTQTTPSSPTPTSVVLTKPKPGQAVKPGAHAKP Aque_Aque_g32534.t1.AA RPHP----------------------------PPKPTKPKPEIPKKPLSEQTSGGLKKPP Nvec_Nvec_PTPN12.AA LPPP---------------------------VPAKTAGAFLVAGTTVTTQ---------- Cele_Y41D4A.5.AA ------------------------------------------------------------ Mbre_Mbre_25202.AA --------------------------------PQWRDKPLPQAGAKTDADEDDDAQCNKD Hsap_PTPN18.AA --------------------------------GSGTQTGTGTGTGARSAEEAPLYSKVTP Hsap_PTPN12.AA PCIADKISKPQELSSDLNVG----------DTSQNSCVDCSVTQSNKVSVTPPEESQNSD Hsap_PTPN22.AA PYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTV Spur_Spur_PTPN12.AA HIAGKPKTKPSPPVKP--------------SSVDVNAKPVSEKTGNGEFFKAIATRQNSN Aque_Aque_g32534.t1.AA PMIPRKGSKPEELSHP--------------VPAPRKPSPVP-PTDDPQVPQAPTALPRTS Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA ------------------------------------------------------------ Mbre_Mbre_25202.AA EAMEN------------------------------------------------------- Hsap_PTPN18.AA RAQRP------------------------------------------------------- Hsap_PTPN12.AA TPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVET Hsap_PTPN22.AA FPSSL--LPTSSTSLFSYYNSHDSLSLNSPT----NISSLLNQESAVLATAPRIDDEIPP Spur_Spur_PTPN12.AA PATRS--TPAKDVSHSAAKNTDKKEALRLPIKPTRNLEKSKSEGDRGMVSPGVRQGPIKP Aque_Aque_g32534.t1.AA TPSKP--LHSTPSSVSSVSNTPDKSVSKSSILETLINEVGLQPDDLVEVS----RDESKP Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA ----------MDEDTSTEEAASVP------------------------------------ Mbre_Mbre_25202.AA ------------KHGNDGVDNSWP------------------------------------ Hsap_PTPN18.AA --------GAHAEDARGTLPGRVPADQSPA------------------------------ Hsap_PTPN12.AA PD--------LVDHDNTSPLFRTPLSFTNPLHSDDSDSDE-RNSDGAVTQNKTNISTASA Hsap_PTPN22.AA PLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDDSVILRPSK Spur_Spur_PTPN12.AA GF-----NKGISKDRPSQPPPKPPASAKPPLQRANGEDRT--SVKGRHDYEEVHISPPHD Aque_Aque_g32534.t1.AA GG-----DYTYASLGATDVPPAIPERTSEALEVMNVPPPL---------YESAELPPPLP Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA ------------------------------------------------------------ Mbre_Mbre_25202.AA ------------------------------------------------------------ Hsap_PTPN18.AA ------------------------------------------------------------ Hsap_PTPN12.AA TVSAATSTESISTRKVLPMS----------------------IARHNIAGTTHSGAEKDV Hsap_PTPN22.AA SVKLRSPKSELHQDRSSPPPPL-------------------------------------- Spur_Spur_PTPN12.AA KVKDTTELPSSKNFRGSPTQQMDSFDAKDSGIIRRKTESLRKLSSGSVQSSGSDSRSSRK Aque_Aque_g32534.t1.AA PVP--------------------------------------------------------- Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA ------------------------------------------------------------ Mbre_Mbre_25202.AA ------------------------------------------------------------ Hsap_PTPN18.AA ------------------------------------------------------------ Hsap_PTPN12.AA DVSEDSPPPLPERTPESFVLASEHNTPVRSEWS--------ELQSQERSEQKKSEGLITS Hsap_PTPN22.AA ----------PERTLESFFLADEDCMQAQ-SIETYSTSYPDTMENSTSSKQTLKTPGKSF Spur_Spur_PTPN12.AA NSDEYAYVQQPTSNIDKLLKSEEGAASPKAASAMYSEAYSEVSSSPNKSGQRMSASSKEY Aque_Aque_g32534.t1.AA --------MNRTSSPSSLLPSSHHHISPTSSSTAFSVATMRNTDLTNKPKKERFSDDTSI Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA ------------------------------------------------------------ Mbre_Mbre_25202.AA ------------------------------------------------------------ Hsap_PTPN18.AA ------------------------GSGAYEDVAGGAQTGGL------------------- Hsap_PTPN12.AA ENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDI------------------- Hsap_PTPN22.AA TRSKSLKILRNMKKSICNSCPPNKPAESV-QSNNSSSFLNF------------------- Spur_Spur_PTPN12.AA SYVDTSKIVAPEKPKRGESVSGGNGDAAYDLVGIPSHDGTFDSFMDTDSTYSATGESLDD Aque_Aque_g32534.t1.AA PSSSKSSSVSPRKAPRSNIAESANNKYSF--------SGNY------------------- Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA ------------------------------------------------------------ Mbre_Mbre_25202.AA ------------------------------------------------------------ Hsap_PTPN18.AA ------------------------------------------------------------ Hsap_PTPN12.AA ------------------------------------------------------------ Hsap_PTPN22.AA ------------------------------------------------------------ Spur_Spur_PTPN12.AA MGSDIPVLPARTAQSYQLVDDEEKDKDEKASGGGKRNKIKARLANSRDIIGEKQGKIVNN Aque_Aque_g32534.t1.AA ------------------------------------------------------------ Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA ------------------------------------------------------------ Mbre_Mbre_25202.AA ------------------------------------------------------------ Hsap_PTPN18.AA ------------------------------------------------------------ Hsap_PTPN12.AA ------------------------------------------------------------ Hsap_PTPN22.AA ------------------------------------------------------------ Spur_Spur_PTPN12.AA TKGLFKRIGVALKPETSHMAPCPEPDTAKPSNINDLLEKTLLDYKPAYKEGPVSYKDQEI Aque_Aque_g32534.t1.AA ------------------------------------------------------------ Nvec_Nvec_PTPN12.AA ------------------------------------------------------------ Cele_Y41D4A.5.AA DFPEEPPAPMGPEDLGSSAAF-------- Mbre_Mbre_25202.AA --PKRVKGPTGPRKVPSTWGLAIKMNYER Hsap_PTPN18.AA GFNLRIGRPKGPRDPPAEWTRV------- Hsap_PTPN12.AA GFGNRCGKPKGPRDPPSEWT--------- Hsap_PTPN22.AA GFANRFSKPKGPRNPPPTWNI-------- Spur_Spur_PTPN12.AA GFPKRVANPRRPRSPPSSWGVRSAQVHL- Aque_Aque_g32534.t1.AA GFGVRVGKPKGPRPPPQQWTAVNGIIH-- Nvec_Nvec_PTPN12.AA -----------------------------