CLUSTAL W (1.81) multiple sequence alignment Dmel_Pez.AA MPLKF---LKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLI Aque_Aque_g12082.t1.AA MPRLF----RKSQRYNV-AKNSWVSKIVLL--DNTSIEINLQPDVTGADCLERVAQCMDI Spur_Spur_PTPN14.AA --MPFGLRLKKTRRYNVSGKNSFVARIQLL--DSAVLEITLTPESLGQDCLDTIAQKLQL Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA --MPFGLKLRRTRRYNVLSKNCFVTRIRLL--DSNVIECTLSVESTGQECLEAVAQRLEL Hsap_PTPN21.AA MPLPFGLKLKRTRRYTVSSKSCLVARIQLL--NNEFVEFTLSVESTGQESLEAVAQRLEL Dmel_Pez.AA QQPEFFGLRYLVKGKDKEDEFKWIDLERSLSRQLEKY------AAGPKIYLRVRHYVTTG Aque_Aque_g12082.t1.AA FEIDYFGLQYQ----CKDGYDRWVDREKSLRKQLDKHHVGGAGARNAELRFLVQYYVTN- Spur_Spur_PTPN14.AA EENIYFGLQYS----NKNYKLRWVDLEKPLKKQLDKN------AHDSMLRLGVMLYTTN- Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA RETHYFGLWFL----SKSQQARWVELEKPLKKHLDKF------ANEPLLFFGVMFYVPN- Hsap_PTPN21.AA REVTYFSLWYY----NKQNQRRWVDLEKPLKKQLDKY------ALEPTVYFGVVFYVPS- Dmel_Pez.AA VRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCRQAEYDSYQG-DKQSKDYLK Aque_Aque_g12082.t1.AA ISKLEYEVTRYLYFLQLKHSVIKGDLKCSSDMAVKLASYALQAEFGDYDA-LIHTPEFLD Spur_Spur_PTPN14.AA IQTLRHEMTRYMYFLQLKSDFIEGILPCNEEQAVTLASFALQAEIGNSDPAKHTVEFYQN Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA VSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAVQADFGDYN--QFDSQDFLR Hsap_PTPN21.AA VSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFD--QYESQDFLQ Dmel_Pez.AA KSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERF Aque_Aque_g12082.t1.AA DHILFPS----------------------------------------------------- Spur_Spur_PTPN14.AA EYVLLPK---NMTTENVSLSELLLKVMNAHQAKVGMSTCQSELGYIEQAAKLQGYGQESF Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA EYVLFPM---DLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIF Hsap_PTPN21.AA KFALFPV---GWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESY Dmel_Pez.AA AAKDTLGNDLLLGLAINGMVVNADNGRQ--YFPWKEFHTVTIDKRTIKIEQNKLDGGGSI Aque_Aque_g12082.t1.AA ---EVNGTRIWIGACFIGIFIKHSNGQPTVYFKWPEIVKMKVKDRCFAIETHHD------ Spur_Spur_PTPN14.AA PAKDDSGNELFISASFSGLSVKHLNRQETVHFEWHEVVSMGHNRRAFGVGTSRSHD---- Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA PVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEE---- Hsap_PTPN21.AA PAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEE---- Dmel_Pez.AA VGSFIFSEADTARYFWKLTISQHKFFKRYI-----DTATPSSLGSGADAESGPLGVDSVG Aque_Aque_g12082.t1.AA SIYFKMADTPTAQYVLEMMVQQHMFFQ-------------------------------TE Spur_Spur_PTPN14.AA VLQFQMEDAETAKYVCRICRLQQQFHK--------YTVETVKLGSREVLVDGFPADKLIT Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA TALFHTDDIENAKYISRLFATRHKFYKQNKICTE-QSNSPPPIRRQPTWSRSSLPRQQPY Hsap_PTPN21.AA TIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVNPIRRRSS-SRMSLPKPQPY Dmel_Pez.AA YVDYDYNEAAAAEQLQQHHQQQQHMQQQQ------------------------------- Aque_Aque_g12082.t1.AA YLDIKWIARRNGK----------------------------------------------- Spur_Spur_PTPN14.AA VVDPERRLSMDGQQMSGKMRNRDSLILGEGASSEENLPHHMMADGQLGNQQFIIGQTGNT Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA ILPPVHVQC--GEHYSETHTSQDSIFHGN------------------------------- Hsap_PTPN21.AA VMPPPPQLHYNGHYTEPYASSQDNLFVPN------------------------------- Dmel_Pez.AA -----------------------QIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLH Aque_Aque_g12082.t1.AA ---------------------------------------------KKSVSLNDIRLHALK Spur_Spur_PTPN14.AA NFTTSQLSLDNQHAYDMGPFTTSQLSLDRPPTDYSYSNGNLVMLDQNGSVYSAPSVNSLN Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA ---------------EEALYCNSHNSLDL-----NYLNGTV----TNGSVCSVHSVNSLN Hsap_PTPN21.AA ---------------QNGYYCHSQTSLDR---AQIDLNGRI----RNGSVYSAHSTNSLN Dmel_Pez.AA SSSGMLHHGGSNNNNNNDERERLKA-----------MLPTYRPAPDYETAV--QLKYRTP Aque_Aque_g12082.t1.AA QSDKKKKEAGSLRKTEERESKFSRP----------------------------------- Spur_Spur_PTPN14.AA YGL-HNQVSPNSSNPSLTNNEKVRA-------HLQASLPAYRQSPDYEAFIQARLQQRLL Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA CSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMR-QMKRGIL Hsap_PTPN21.AA NPQPYLQPSPMSSNPSITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMK-QLNRGLV Dmel_Pez.AA SAEFHNVALAMAAPGNAYYAGSQPDVHNP-----------------GMHNENLLYGHMTA Aque_Aque_g12082.t1.AA -------------------LGKRDSLLEP------------------------------- Spur_Spur_PTPN14.AA TVSEQSQSVGNL--GKQNGYGHMESVLYPQPELRQHNHNNHYRQQFRLSYGGTPNNYYTG Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA HTDSQSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQR Hsap_PTPN21.AA HAERQSHSLRNLNIGSSYAYSRPAALVYSQPEIREHAQLPSPAAAHCPFS--LSYSFHSP Dmel_Pez.AA HRYPDVAQPAAA----LHHHINLYQAQHQPQSHPQPMSPAQAYLELSQRMHMMRHKAPPP Aque_Aque_g12082.t1.AA -------------------------------LSPSHHGLEEDLSP-----REIVLTTPPG Spur_Spur_PTPN14.AA NNMDYSLESLQHGLLIKTPHGNIVHTISVPELTSEHIQTTEEYIT-AKLLKNK-YKPPPP Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA NPKNNVVPS-------KPGASAISHTVSTPELANMQLQGSHNYST-AHMLKNYLFRPPPP Hsap_PTPN21.AA SPYPYPAER-------RP----VVGAVSVPELTNAQLQ-AQDYPS-PNIMRTQVYRPPPP Dmel_Pez.AA YVNRLSSSSTPDLAVATPRPLQGFRNY-VSGSSPDLVSNRTL------------------ Aque_Aque_g12082.t1.AA AVSDSTACLTPT------------------------------------------------ Spur_Spur_PTPN14.AA Y--PRGSASTPNLARQS-------NNYLVSSSSPDLVSRRLQAIEAMHEVNLHGSGNVNI Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA YPRPRPATSTPDLASHR-------HKY-VSGSSPDLVTRKVQ------------------ Hsap_PTPN21.AA YPPPRPANSTPDLS--R-------HLY-ISSSNPDLITRRVH------------------ Dmel_Pez.AA -------FNGGQYVALPAGGHAGNIPT------------------SSGATMLHQYQYVSH Aque_Aque_g12082.t1.AA ---------------------------------------------AWMEGAEEREKEEEK Spur_Spur_PTPN14.AA DADLSQSLPIEAFQQMRIQDYHAQVGMYSRHVSQGYQQQYSPQQREFKPALTLNLTDKAQ Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA -------LSVKTFQE------------------------------DSSPVVHQSLQEVSE Hsap_PTPN21.AA -------HSVQTFQE------------------------------DSLPVAH-SLQEVSE Dmel_Pez.AA MGHSQPYLPPHGTFENLNMIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYR Aque_Aque_g12082.t1.AA PTMKKKREKGLGRTGVLECIPVNEDGID----IGEPICTSPTDMVTVNEATIDTREHHNA Spur_Spur_PTPN14.AA PSDLSMIAVPTGYEDNLPTPPDKSRIMSPFQEYAGPLVSPPSE---FADHSDIDSNMSPG Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA PLTATKHHGTVNKRHSLEVMNSMVRGMEAMTLKSLHL---------PMARRNTLREQGPP Hsap_PTPN21.AA PLTAAR-HAQLHKRNSIEV-AGLSHGLEGLRLKERTLSASAAE---VAPRAVSVGSQPSV Dmel_Pez.AA SSVPPPASSPLPPPVV-ASSHKSATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAAN Aque_Aque_g12082.t1.AA VGGEVTSSIPNLSH---------PLPPPIMHHQVSSANGGSSGSQESFELS--------- Spur_Spur_PTPN14.AA SVGSPTRHFHLPPHGMGDIYNSQPSLPENHLTYVTGGFGQMNGTGQLGSPTRVYSMPQLH Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA EEGSGSHEVPQLP----QYHHKKTFSDATMLIHSSESEEEEEEAPESVPQI--------- Hsap_PTPN21.AA FTERTQREGPEEAEGL-RYGHKKSLSDATMLIHSSEEEEDEDFEEESGARA--------- Dmel_Pez.AA TEAMRQRASSIQSAPGVVPVPAARNASSNNVVTVTVNSPPDDGNIKKYGADRAASTELLF Aque_Aque_g12082.t1.AA -----------------------------HTKKEYLSASLNQLDSRTP------------ Spur_Spur_PTPN14.AA PEMREQQHHTSEIETILAERKTNQS---QGFATSMHANPKDNITQETPLNDHTTQSSSPT Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA PMLREKMEYSAQLQAALARIPNKPPPEYPGPRKSVSNGALR--QDQASLPPAMARARVLR Hsap_PTPN21.AA PPARAR-----EPRPGLAQDP-------PGCPRVLLAGPLHILEPKAHVPD--AEKRMMD Dmel_Pez.AA LEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMNLS Aque_Aque_g12082.t1.AA ------------PNTLKLTKTPPPL----------------------------------- Spur_Spur_PTPN14.AA PAL---------PQSTDDVHSHKPKQPELKASSVSSKPSTNPPSTTQQPSTSKASSTPPA Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA HGP---------AKAISMSRTDPPAVNGASLGPSISEP---DLTSVKERVKKEPVKERPV Hsap_PTPN21.AA SSP---------VR--TTAEAQRPWRDGL-LMPSMSES--DLTTSGRYRARRDSLKKRPV Dmel_Pez.AA ANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSATLGREKATTAGQ Aque_Aque_g12082.t1.AA ------------------------------------------------------------ Spur_Spur_PTPN14.AA TSSSNHKQTVASKSPTLPLSPDSEGSEVLEDLGTDNGGYIGP------------------ Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA SEMFSLEDSIIEREMMI-------RNLEKQKMAGLEAQKR-P------------------ Hsap_PTPN21.AA SDLLSGKKNIVEGLPPL-------GGMKKTR---VDAKKIGP------------------ Dmel_Pez.AA HSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDSQLFMEFERI Aque_Aque_g12082.t1.AA --------------LSPDTQW-------EQEATSGTRDKRAQHLEMILQSGKVYPEFEEI Spur_Spur_PTPN14.AA -LKLAAMSGLTLLRPRDMPAQ-------PEEETKHPRDARRKILEKQLREGQVFTEYEQI Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA -LMLAALNGLSVARVSGREEN-------RVDATRVPMDERFRTLKKKLEEGMVFTEYEQI Hsap_PTPN21.AA -LKLAALNGLSLSRVPLPDEG-------KEVATRATNDERCKILEQRLEQGMVFTEYERI Dmel_Pez.AA PKRR-EHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATVGT Aque_Aque_g12082.t1.AA PPMS-LDADTSAGSNPVNAKKNRYKDIIPYEHNRIRLNPNKNTGSNDYINASLVSYSVGS Spur_Spur_PTPN14.AA TKKR-EGAVCYTSKLPENVSRNRFKDVLPYEDCRVELSSSHHN-SGGYINASRVKVPVAG Nvec_Nvec_PTPN14.AA -------------------------------------MPTK------------------- Hsap_PTPN14.AA PKKK-ANGIFSTAALPENAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKVVVGG Hsap_PTPN21.AA LKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKVSVSG . . Dmel_Pez.AA KQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTED--------MSYIPRN---SHQR Aque_Aque_g12082.t1.AA QHRSYIVCQGPL-EITCCDFWQMIWEQKTQLILMLTNIIENGKTKCHQYFPNDEE-NAKH Spur_Spur_PTPN14.AA ELLHYIAAQGPM-ENTVQDWWRMVWESGTQVIAMLTKLKEDGKEKCFKYWPDCTSPKKNT Nvec_Nvec_PTPN14.AA ------------------------------------------------------------ Hsap_PTPN14.AA AEWHYIATQGPL-PHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGS-KHSS Hsap_PTPN21.AA IEWDYIATQGPL-QNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGS-RHNT Dmel_Pez.AA LEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDF Aque_Aque_g12082.t1.AA VQFEQYRISTKFVEKSPSVITRCFTVHYMPTSEEREIMILQYIDWPDHGIPPDPQPFISY Spur_Spur_PTPN14.AA AEFGPFRVIAQFSNDSGCYITSGLTLRHVPSGEQRTVWHLQYNDWPNQGCPDDVHGFLSF Nvec_Nvec_PTPN14.AA --------------------------------QQRTVYHVQFTDWPDHRVPDDPTSFLEF Hsap_PTPN14.AA ATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSY Hsap_PTPN21.AA VTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSY * : :*: **.:: * * *:.: Dmel_Pez.AA LEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRV Aque_Aque_g12082.t1.AA LRMVKSLRYKFDESI--------PIVVHCSAGVGRSGVLVLSDMLTETYDCGEVIDIKSS Spur_Spur_PTPN14.AA LEEFQSVCRHANSMNE--VEVGPPPIVHCSAGVGRTGVLLLVDIMISSLEHNEEINIPKM Nvec_Nvec_PTPN14.AA LDQVESLRQRTSTTRSSVHESKPPVLVHCTAGVGRTGVIILTDLMIACIQNNKRINIHHA Hsap_PTPN14.AA LEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMM Hsap_PTPN21.AA LEEIQSVRRHTNSTSDP-QSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRV * .:*: * ::** * **:** : ::: : .: ::: Dmel_Pez.AA IGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTRLI Aque_Aque_g12082.t1.AA LARLRLQRMHLVQTLGQYRFLYTVIIKYINNARLI Spur_Spur_PTPN14.AA MGILRQQRMLMVQTVGQYTFVYKALIQSLKNTRLI Nvec_Nvec_PTPN14.AA LVRLRRQRMLLVANFGQYRFVYSTVIHYIKNSRLI Hsap_PTPN14.AA LRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI Hsap_PTPN21.AA LDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI : ** ** :: .. ** *:* :* :: :***