CLUSTAL W (1.81) multiple sequence alignment Dmel_PTP-ER.AA MDKLRNNNKENAPIEYPYPQTPRPTHAAPSDTTPLEAGEDAESNKSTPYFTPLEYLQTSF Aque_Aque_g23828.t1.AA -----MKQLPALVFLLLAVAAMSQNSTNDTDTEEMLSVSSSLDFEMLTSMLPESIEPTSM Hsap_PTPN7.AA --------------------------------------MGASFWPIRQAR---------- Hsap_PTPN5.AA --------------------MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVM Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA -----MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLD Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA EFPSPTVEVGGGVPGFPEHEDQEEEVFTPRQFTITSPHPAAHVHHPSSSQSPTLGRKFKR Aque_Aque_g23828.t1.AA INMSSSVAD-------LDQTDTPQNVTQIDQSSSIAYSSDIMSMAITDTTPKTSSAIQSL Hsap_PTPN7.AA --------------------EQQRRALSFRQTSWLSEPPLGPAPHLSMVQAHGGRSRAQP Hsap_PTPN5.AA EAL-----------------DEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLT Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA IAPQKIYRH-------SYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVEN Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA LSQYDRRSCSPHINTSSGEERVSGRGIDKENTMPKGGSVDQDLENSLYLSKSEHNSPTIL Aque_Aque_g23828.t1.AA PPSDPSMPPSQSMYLSQNMYSSQGMSSLETMYVSPSQGMPPSQSSISSINTSSVSSLLST Hsap_PTPN7.AA ------------------------------------------------------------ Hsap_PTPN5.AA VRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNL--------VSSLLTLLKQLEPTAW Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA LPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVS Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA FKDESSTTPGLEASRLSYSPKLLSSINNLNVSGSPLNIINSAGYKNGNFFRFPEIDHVVQ Aque_Aque_g23828.t1.AA IPAAATSTPTLTP-----SPTESLTSSSMYLPTSDDIFDFFSSSDDGAVIPTPSSAHSTT Hsap_PTPN7.AA ------------------------------------------------------------ Hsap_PTPN5.AA LDSGTWGVPSLLL----------------------------------------------- Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA PINRKTGISDALP-----SEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIW Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA DAPMDTVCLEEATRRDRSPALAEPPEQQQQKSEGRKNRKNKNNLTIRITDVPIKNSSQPS Aque_Aque_g23828.t1.AA SKVVSQSSS----------------------------------SSLSVTSATINSTQSVT Hsap_PTPN7.AA -------------------------------------------LTLSLGAA--------- Hsap_PTPN5.AA -------------------------------------------VFLSVGLVLVTTLVWHL Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA SKEGFYAVV----------------------------------IFLSIFVIIVTCLMILY Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA PLPKPKTPTIKSTKEKARSLDSAANESELSIVVHNITESHGSCDDMETGQSQPSTSVIHH Aque_Aque_g23828.t1.AA LSSSSVSSSLSVTSATIMSTQSSVSSESLG------------------------------ Hsap_PTPN7.AA ------------------------------------------------------------ Hsap_PTPN5.AA LRTPPEPPT--------------------------------------------------- Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA RLKERFQLSLRQDKEKNQEIHLSPITLQPA------------------------------ Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA HLHLQQPASAIHSTSLSRLDSHLSLANQRRTPRRKSPGINTTDWLMYHRKQNPYQVQPTH Aque_Aque_g23828.t1.AA ----------------------VSPPIPTSTPTESSTGIPVVVWAPVGAGLGLLVIALVA Hsap_PTPN7.AA ----------------------MTQPPPEKTPAK-------------------------- Hsap_PTPN5.AA ----------------------PLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVP Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA ----------------------LSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIRATT Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA CSSTTQSSLDSDASLTPSLGDFELKSACSVDGGSKFGIGASLAPRSAHKHNQLLHSSSTN Aque_Aque_g23828.t1.AA CMVIVGLVV--------------------------------------------------- Hsap_PTPN7.AA ------------------------------------------------------------ Hsap_PTPN5.AA ETPVFDCVMDIKPEADPT------------------------------------------ Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA ATSVCPS----------------------------------------------------- Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA LKTLPECLTLVEFSSSGGGPKESPFKQKSMDLPMPTLQAKTTVSTSSMNLLQRRGSNHSL Aque_Aque_g23828.t1.AA -----------------------------------------LLRRRKRTKDKKKPRNYWE Hsap_PTPN7.AA ---------------------------------------------KHVRLQERRGSNVAL Hsap_PTPN5.AA -----------------------------------------SLTVKSMGLQERRGSNVSL Nvec_Nvec_PTPN5.AA ----------------------------------------------------RRGSKASL Hsap_PTPRR.AA -----------------------------------------PFKMKPIGLQERRGSNVSL Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA TLNLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQGS Aque_Aque_g23828.t1.AA SIHTNRHLG--------------------------------------------------- Hsap_PTPN7.AA MLDV-------------------------------------------------------- Hsap_PTPN5.AA TLDM-------------------------------------------------------- Nvec_Nvec_PTPN5.AA VLDL-------------------------------------------------------- Hsap_PTPRR.AA TLDM-------------------------------------------------------- Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA RQGLFRRRGSNHSITLKTGHTTTSCGDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTGSGS Aque_Aque_g23828.t1.AA -----------------------------------------------------SAANVTM Hsap_PTPN7.AA -----------------------------------------------------RSLG-AV Hsap_PTPN5.AA -----------------------------------------------------CTPGCNE Nvec_Nvec_PTPN5.AA -----------------------------------------------------TSSSTDL Hsap_PTPRR.AA -----------------------------------------------------SSLG-NI Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA GSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVCSCAAANQA Aque_Aque_g23828.t1.AA GHIAPLPRPNQVSRT--------------------------------------------- Hsap_PTPN7.AA EPICSVNTPREVTL---------------------------------------------- Hsap_PTPN5.AA EGFGYLMSPREESAR--------------------------------------------- Nvec_Nvec_PTPN5.AA GPGSPAPSIRESPVE--------------------------------------------- Hsap_PTPRR.AA EPFVSIPTPREKVAM--------------------------------------------- Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA PHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQDSVREDQAIGATCTCAGTVR Aque_Aque_g23828.t1.AA ------------------------------------------------------------ Hsap_PTPN7.AA ------------------------------------------------------------ Hsap_PTPN5.AA ------------------------------------------------------------ Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA ------------------------------------------------------------ Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA NIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPP Aque_Aque_g23828.t1.AA ------------------------------------------------------------ Hsap_PTPN7.AA ------------------------------------------------------------ Hsap_PTPN5.AA ------------------------------------------------------------ Nvec_Nvec_PTPN5.AA ------------------------------------------------------------ Hsap_PTPRR.AA ------------------------------------------------------------ Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA VLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQKRIFRDLHKEFW Aque_Aque_g23828.t1.AA -----------------------SLVSRGHYQLDHLSKPMSVTELEHCLRYYGSLHDQYM Hsap_PTPN7.AA ------------------------------HFLRTAGHPLTRWALQRQPPSPKQLEEEFL Hsap_PTPN5.AA ------------------------------EYLLSASRVLQAEELHEKALDPFLLQAEFF Nvec_Nvec_PTPN5.AA ------------------------------EKLSAKSKLITFEELGECVDNTKQLYAEFW Hsap_PTPRR.AA ------------------------------EYLQSASRILTRSQLRDVVASSHLLQSEFM Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA DLPLNH--QEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASE Aque_Aque_g23828.t1.AA SIPANMTSMNEIP-SGAQEKNRYCDVLPNPNSRVVLFLKFGI-----------------A Hsap_PTPN7.AA KIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQ-----------------E Hsap_PTPN5.AA EIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPD----------------DP Nvec_Nvec_PTPN5.AA EIPMNH-PPAEERLPGSSYRNRYPSILPNSRTRVSL-PQIPD----------------DP Hsap_PTPRR.AA EIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVT----------------DS Spur_Spur_PTPN5.AA ------------------------------------------------------------ Dmel_PTP-ER.AA DLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHV Aque_Aque_g23828.t1.AA NSDYINANFIRGYRGQSKAYIATQGPLPFTIADFWRMVW--------------------- Hsap_PTPN7.AA DGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVW--------------------- Hsap_PTPN5.AA LSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVW--------------------- Nvec_Nvec_PTPN5.AA LSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIW--------------------- Hsap_PTPRR.AA LSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVW--------------------- Spur_Spur_PTPN5.AA -----------GYDREPTAFVATQGPMAHTLADFWRMIW--------------------- * . ::*****: *: :** *:: Dmel_PTP-ER.AA DREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDR Aque_Aque_g23828.t1.AA ------EQRTTVIIMTTGLVERNMAKCNQYWP---------------------------- Hsap_PTPN7.AA ------QEEVSLIVMLTQLREGK-EKCVHYWP---------------------------- Hsap_PTPN5.AA ------QEHTPIIVMITNIEEMN-EKCTEYWP---------------------------- Nvec_Nvec_PTPN5.AA ------YHHCPIIVMITKLKERNETKCERYWP---------------------------- Hsap_PTPRR.AA ------QEDSPVIVMITKLKEKN-EKCVLYWP---------------------------- Spur_Spur_PTPN5.AA ------FTNAPVIVMVTKIKERKRSKCEMYWP---------------------------- *:* * : * : ** *:* Dmel_PTP-ER.AA YLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVR Aque_Aque_g23828.t1.AA ---------------DTHGYGVTETYGDIQ----------------------VTVRKKVN Hsap_PTPN7.AA ---------------TE-----EETYGPFQ----------------------IRIQDMKE Hsap_PTPN5.AA ---------------EE-----QVAYDGVE----------------------ITVQKVIH Nvec_Nvec_PTPN5.AA ---------------DPT-FRMQEKYGDIV----------------------VTFDSALG Hsap_PTPRR.AA ---------------EK-----RGIYGKVE----------------------VLVISVNE Spur_Spur_PTPN5.AA ---------------QG-----QGFYGDID----------------------VTVEETVP : . : Dmel_PTP-ER.AA RNGYSVRKLVLLYCIR-VPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLN Aque_Aque_g23828.t1.AA HNDYTLTTFLVQHLERHVTRE---------VIHYWYTNWPDMGVPDNPSSVVDFL----- Hsap_PTPN7.AA CPEYTVRQLTIQYQEE--RRS---------VKHILFSAWPDHQTPESAGPLLRLV----- Hsap_PTPN5.AA TEDYRLRLISLKSGTE--ERG---------LKHYWFTSWPDQKTPDRAPPLLHLV----- Nvec_Nvec_PTPN5.AA RDGYQITSLYISHSQS--PRR---------LYHYWYTAWPDHGVPDSPRQLLQLV----- Hsap_PTPRR.AA CDNYTIRNLVLKQGSH--TQH---------VKHYWYTSWPDHKTPDSAQPLLQLM----- Spur_Spur_PTPN5.AA KDDYILKIFTLKYLNE--CRQ---------VLHYWYTAWPDNKPPENPVTLLEMI----- * : : : . * :. *** * :: Dmel_PTP-ER.AA LGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVI-HCSAGIGRTGCFTAI Aque_Aque_g23828.t1.AA --------------------------LETRRSRE-SFTMPGPAVVHCSAGIGRTGVFIGA Hsap_PTPN7.AA --------------------------AEVEESPE-TAAHPGPIVVHCSAGIGRTGCFIAT Hsap_PTPN5.AA --------------------------REVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIAT Nvec_Nvec_PTPN5.AA --------------------------DEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVAT Hsap_PTPRR.AA --------------------------LDVEEDRL-ASQGRGPVVVHCSAGIGRTGCFIAT Spur_Spur_PTPN5.AA --------------------------REVEFSRIDPTLPRGPVIVHCSAGLGRTGCYIAI : * : *****:**** : . Dmel_PTP-ER.AA LNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEA Aque_Aque_g23828.t1.AA DIGMRELEE--------------------------------------------------- Hsap_PTPN7.AA RIGCQQLKA--------------------------------------------------- Hsap_PTPN5.AA SICCQQLRQ--------------------------------------------------- Nvec_Nvec_PTPN5.AA SIGIKQIQK--------------------------------------------------- Hsap_PTPRR.AA SIGCQQLKE--------------------------------------------------- Spur_Spur_PTPN5.AA TLGMRQMDE--------------------------------------------------- .:: Dmel_PTP-ER.AA VKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLYLKRTLALRR Aque_Aque_g23828.t1.AA --------------TQMIDVLRIVANMRQDRGGMVQTKDQYVFLHKILYEYAKRIGYVVP Hsap_PTPN7.AA --------------RGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPS Hsap_PTPN5.AA --------------EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSP Nvec_Nvec_PTPN5.AA --------------ENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWRQL----- Hsap_PTPRR.AA --------------EGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETV Spur_Spur_PTPN5.AA --------------ESMVDILGIVCQIRQDRGGMIQTNEQYEFIHQALCLYEKCLPRRES :* * .. :* :****::. .** :::. : : Dmel_PTP-ER.AA F---------------------------- Aque_Aque_g23828.t1.AA RIHGMNDFEEERYSENDLDDHIETTTTFV Hsap_PTPN7.AA P---------------------------- Hsap_PTPN5.AA E---------------------------- Nvec_Nvec_PTPN5.AA ----------------------------- Hsap_PTPRR.AA Q---------------------------- Spur_Spur_PTPN5.AA -----------------------------