CLUSTAL W (1.81) multiple sequence alignment Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA ------------------------------------------------------------ Hsap_PHLPP1.AA MEPAAAATVQRLPELGREDRASAPAAAAAAAAAAAAAAAALAAAAGGGRSPEPALTPAAP Hsap_PHLPP2.AA ------------------------------------------------------------ Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA ------------------------------------------------------------ Hsap_PHLPP1.AA SGGNGSGSGAREEAPGEAPPGPLPGRAGGAGRRRRRGAPQPIAGGAAPVPGAGGGANSLL Hsap_PHLPP2.AA --------------------------------------------------MKRNGSRNCL Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA ------------------------------------------------------------ Hsap_PHLPP1.AA LRRGRLKRNLSAAAAAASSSSSSSAAAASHSPGAAGLPASCSASASLCTRSLDRKTLLLK Hsap_PHLPP2.AA NRRSRFG----------------------------------------------------- Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA ------------------------------------------------------------ Hsap_PHLPP1.AA HRQTLQLQPSDRDWVRHQLQRGCVHVFDRHMASTYLRPVLCTLDTTAGEVAARLLQLGHK Hsap_PHLPP2.AA --------SRERDWLREDVKRGCVYLYG-------------------------------- Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA ------------------------------------------------------------ Hsap_PHLPP1.AA GGGVVKVLGQGPGAAAAREPAEPPPEAGPRLAPPEPRDSEVPPARSAPGAFGGPPRAPPA Hsap_PHLPP2.AA ------------------------------------------------------------ Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA ------------------------------------------------------------ Hsap_PHLPP1.AA DLPLPVGGPGGWSRRASPAPSDSSPGEPFVGGPVSSPRAPRPVVSDTESFSLSPSAESVS Hsap_PHLPP2.AA ------------------------------------------------------ADTTTA Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA -------------MSDENLET--------------------------------------- Hsap_PHLPP1.AA DRLDPYSSGGGSSSSSEELEADAASAPTGVPGQPRRPGHPAQPLPLPQTASSPQPQQKAP Hsap_PHLPP2.AA TTTTTTSSSSSSSSSSSDLHL-------------------------------------VL Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA ------------------------------------------------------------ Hsap_PHLPP1.AA RAIDSPGGAVREGSCEEKAAAAVAPGGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETT Hsap_PHLPP2.AA CTVETPASEICAGEGRE--------------------------------SLYLQLHGDLV Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA ---ESTSKALEDILSY---------------TDSPAFRHIFSFFLGRPRIRAKSTLNLDI Hsap_PHLPP1.AA RRLEAEEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKP--HSTGSSERIQ Hsap_PHLPP2.AA RRLEPTERPLQIVYDYLSRLGFDDPVRIQEEATNPDLGCMIRFYGEKP--CHMDRLDRIL Dmel_Phlpp.AA ---------------MLKATRKQADPYKSKLKVSA---SHSGP-HPLPVEVTAAEE---- Cele_F43C1.1.AA LSEEVVIRKGKL---IHTWQNARAVFYNSNIRLQT-KNNQDEALQIRNMKVDVHESKRGR Hsap_PHLPP1.AA LSGMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKKH Hsap_PHLPP2.AA LSGIYNVRKGKTQ--LHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRR : . : : :.: : : *. Dmel_Phlpp.AA ----------EQAATF-------------------------------------------- Cele_F43C1.1.AA ALRLK-----DDDVCYLIIFQRPNILEAWLTRAQQV--EKSNHVDASDEQLTLIPEQILN Hsap_PHLPP1.AA QHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFY Hsap_PHLPP2.AA QYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTVDLSCYSLEEVPEHLFY : : Dmel_Phlpp.AA ---------------GQTSP--------------------QKLSLKGSQLG--------- Cele_F43C1.1.AA NEARVQILNLRRNSLISRPPTEKSMAPLGYIDDLYRVHSLQVIDLSANQILSFPIQLTLL Hsap_PHLPP1.AA SQD-LTHLNLKQNFLRQNPS----LPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSI Hsap_PHLPP2.AA SQD-ITYLNLRHNFMQLERP--------GGLDTLYKFSQLKGLNLSHNKLGLFPILLCEI . : :.*. .:: Dmel_Phlpp.AA ------------------------------------------------------------ Cele_F43C1.1.AA SHLRQLNLSSNYISSVPSECSNMRRLQYLNLSNNQLDTLPDSISELQNLQSLDISFNQFS Hsap_PHLPP1.AA PTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFT Hsap_PHLPP2.AA STLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFS Dmel_Phlpp.AA ------------------GSIL--------------------------------IGNYNY Cele_F43C1.1.AA QIPPCLFHLT-LEMWRLAGNNIEKIDRVGEM----QIQKIDLRRNVLDTSFRLDIEN--- Hsap_PHLPP1.AA DIPEVLEKLTAVDKLCMSGNCVETL-RLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQH Hsap_PHLPP2.AA QIPEVYEKLTMLDRVVMAGNCLEVL-NLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKH *. : : Dmel_Phlpp.AA LTQLEVCENEM-EVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTN Cele_F43C1.1.AA ITHLDLRDNSMISTVHLTNLRFLKVIHCERLQLSSLHLSGESLTHVYADHNLLDSL---V Hsap_PHLPP1.AA VTQLDLRDNKL-GDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQL---D Hsap_PHLPP2.AA ITHVDLRDNRL-TDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAV---N :*:::: :* : : : :: ::* * :* * : * * : *. * * : Dmel_Phlpp.AA THPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLD Cele_F43C1.1.AA VMPLPQNLQTLSLSFNHFRNLPDWISDCPNLTFLRANNNSLVALPE--RIFYSQSLRSIF Hsap_PHLPP1.AA VYPVPNYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPA--RLFCNSSLRKLL Hsap_PHLPP2.AA VYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPV--RILSSLSLRKLM . *:* * :.:* * : :*:* . .: : . * : :. * .* .: Dmel_Phlpp.AA LAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLP-- Cele_F43C1.1.AA AFINEIEHIPDFGEE-NCLETLILYKNKLSSLPKHFFSIL-PRLRQLNISSNFIELLP-- Hsap_PHLPP1.AA AGHNQLARLPERLER-TSVEVLDVQHNQLLELPPNLLMKA-DSLRFLNASANKLESLPPA Hsap_PHLPP2.AA LGHNHVQNLPTLVEH-IPLEVLDLQHNALTRLPDTLFSKA-LNLRYLNASANSLESLPSA * : .: * : * : * * ** :: * ** *.* :. ** Dmel_Phlpp.AA RYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEI Cele_F43C1.1.AA YFDGSSFCRLQILRCANNYLTENSVPVIVNMKHLKIIDLSHNRLNSFDDSALSSLELLED Hsap_PHLPP1.AA TLSEETNSILQELYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEE Hsap_PHLPP2.AA CTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEE .. . * * :.* *.:. . : . :*.:: :: *.: : : : . ** Dmel_Phlpp.AA LVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLA Cele_F43C1.1.AA LNLSSNRLTRLADCLALLPCLQVLRAHSNQLVHVPEFRASNQLHTIDVSSNNISLGTLQF Hsap_PHLPP1.AA IDLSGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPE Hsap_PHLPP2.AA LNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPE : **.* * :. : :..: . .* : *:. :: :*:* * : : Dmel_Phlpp.AA LVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQ Cele_F43C1.1.AA KAPP-NLRHFDVTCNSG-DFDTENFPE----NAKMHSKMNTINIS--------------- Hsap_PHLPP1.AA NLPP-KLQELDLTGNPRLVLDHKTLEL--------LNNIRCFKIDQ---PSTG------- Hsap_PHLPP2.AA ALPA-TLQDLDLTGNTNLVLEHKTLDI--------FSHITTLKIDQKPLPTT-------- *. .*. :*:: * .: : : . : . Dmel_Phlpp.AA RNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEM Cele_F43C1.1.AA -EGSQNLFGFQIGVSGSRGMKN--KQCIRQVRVENT-------FGFID-----GGSNSYM Hsap_PHLPP1.AA -DASGAPAVWSHGYTEASGVKN--KLCVAALSVNNFCDNREALYGVFD-----GDRNVEV Hsap_PHLPP2.AA -DSTVTSTFWSHGLAEMAGQRN--KLCVSALAMDSFAEGVGAVYGMFD-----GDRNEEL : . : * : * : * .: : . :*.:: * : Dmel_Phlpp.AA SHLVPDLMKQ---EQMVKDSAVRDYMKFTLLAAQQQCGSV--RSAALFHLTRTRAPSKVR Cele_F43C1.1.AA SSSICRFMTSYLKENVSMD------IRSILLRCHCELGEEGERLGASVMIIRV--HEK-- Hsap_PHLPP1.AA PYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIK-HDPVD Hsap_PHLPP2.AA PRLLQCTMADVLLEEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIR-PDTAD . : * . *:: : :: : : * . .. : . Dmel_Phlpp.AA PLKSKRYVLRMASTGGLDAYLIRRTS-QLRLTKPDVIQKD------------------QI Cele_F43C1.1.AA -------RLEIASTGTMSAAIARNQKLKMIINGRYEIDDD--EYSRIREAHGFVDEENRI Hsap_PHLPP1.AA PGGS--FTLTSANVGKCQTVLCRNGK-PLPLSRSYIMSCE-EELKRIKQHKAIITEDGKV Hsap_PHLPP2.AA PASS--FSLTVANVGTCQAVLCRGGK-PVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKV * *..* .: : * . : :. :. : .: Dmel_Phlpp.AA HSM-----------------PDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKE Cele_F43C1.1.AA NGVIGSSRQIGHFSTFPVVLPTHSYRNIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNN Hsap_PHLPP1.AA NGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNV Hsap_PHLPP2.AA NGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHV :.: * . *. : * :::*. :*. :. ..: Dmel_Phlpp.AA ENSLLAAKRLVDIAQSFAAAESLSVIVVRF----------------RHLGTDVDHLIREL Cele_F43C1.1.AA RSPIVVAKKIQDQLQSYDYGGNSNILVLRR----------------IKPQMTFNGFSTSS Hsap_PHLPP1.AA PDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPSV Hsap_PHLPP2.AA QDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEG-CTCEMN---GLTLPGPVGFASTT ..: .**.: **: . . :*: : Dmel_Phlpp.AA KQSVRKKPQP-VSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAK Cele_F43C1.1.AA T---KNQVTPDIAIPKIDEQLVLAVPALI-----------------------LPEYHPSP Hsap_PHLPP1.AA NMVIKDRPSDGLGVPSSSSGMASEISSELSTS--EMSSEVGSTASDEPPPGALSENSPAY Hsap_PHLPP2.AA T--IKDAPKP--ATPSSSSGIASEFSSEMSTS--EVSSEVGSTASDEHNAGGLDTALLPR . .. . * . : . . Dmel_Phlpp.AA DKDDEFVLAHARVLQE-EQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELN Cele_F43C1.1.AA P-------VPPPIPAIRHRTPSPP------------------------------------ Hsap_PHLPP1.AA PSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFTNGSRVEVEVDIH Hsap_PHLPP2.AA P-ERRCSLHPTPTSGLFQRQPSSATFSSNQSDNGLDSDDDQPVEGVITNGSKVEVEVDIH . . Dmel_Phlpp.AA TISKSFTKQRTVPNAIMAATVLPERND---------FTSNLMRTVTNKFISTSTPQLPQP Cele_F43C1.1.AA ------------PPPLPSSTPPPVSSE------------------------HEEINVRQS Hsap_PHLPP1.AA C---SRAKEKEKQQHLLQ-VPAEASDE-----------------GIVISANEDEPGLPRK Hsap_PHLPP2.AA C---CRGRDLENSPPLIESSPTLCSEEHARGSCFGIRRQNSVNSGMLLPMSKDRMELQKS : .: . : . Dmel_Phlpp.AA ITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAKPRPKFHGGTVKRSAGPNSA Cele_F43C1.1.AA ST-----------LSG-----GYTLSIDR------------------------------- Hsap_PHLPP1.AA ADFSA-VGTIGRRRAN-----GSVAPQERSHNV-IEVATDAPLRKPGG------------ Hsap_PHLPP2.AA PSTSC-L--YGKKLSN-----GSIVPLEDSLNL-IEVATEVPKRKT-G------------ * . : Dmel_Phlpp.AA YFGSLQRLMPYNFEYDFAVTQERERNILDEEEHDDDDFNEHES----RMRK--------- Cele_F43C1.1.AA FYSSSSTVSS---RKQF-------NETRDLLSKSL------------KLSP--------- Hsap_PHLPP1.AA YFAAPAQPDP---DDQFIIPPELEEEVKEIMKHHQEQQQQQQPPPPPQLQPQLPRHYQLD Hsap_PHLPP2.AA YFAAPTQMEP---EDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEP--------- ::.: . :* : : .: . Dmel_Phlpp.AA -YWGVATTEL Cele_F43C1.1.AA --PNTVTFNI Hsap_PHLPP1.AA QLPDYYDTPL Hsap_PHLPP2.AA --PEEFDTAL :