CLUSTAL W (1.81) multiple sequence alignment Scer_PTC1.AA ------------------------------------------------------------ Ddis_DDB_G0284243.AA MSTTNTDMIDSSSDIKDETITHNNDTVDTTKATEITADKNLEVSIDKNKENKNTADDNKE Mbre_mbre_25189.AA -------------MGQTDSKSTGMQRRSS------------------------------- Mbre_mbre_33662.AA ------------------------------------------------------------ Mbre_mbre_33092.AA ------------------------------------------------------------ Hsap_PPM1N.AA -------------MAVLARQLQRLLWTACKKKEREKEGREEEEEEEAGRRAPEG------ Cele_tag-93.AA -------------MTISRADLQIASSAEPKTHGNLNESFAPEIRQTASTIASLSIFGTPS Aque_g24834.t1.AA ------------------------------------------------------------ Dmel_CG6036.AA ------------------------------------------------------------ Dmel_alph.AA ------------------------------------------------------------ Nvec_nvec_213347.AA ------------------------------------------------------------ Spur_spur_hmm2044,hmm5714.AA ------------------------------------------------------------ Hsap_PPM1A.AA ------------------------------------------------------------ Hsap_PPM1B.AA ------------------------------------------------------------ Scer_PTC1.AA ---------------------------------MSNHSEILERPETPYDIT--------- Ddis_DDB_G0284243.AA KEKEKENINNNNNNDTTNNNNSNNNNNNTPPKESNNTTTTTKSEESSSDDTYN--SGTGD Mbre_mbre_25189.AA ------------------------------------VSAFLPSPKTDITSMDQ--RTAD- Mbre_mbre_33662.AA ------------------------------------MGAFLEKPVTEKHHDAAT-LPNG- Mbre_mbre_33092.AA ------------------------------------MGSFLDKPKYEKETHHN--QGNN- Hsap_PPM1N.AA ------------------------------------PRSLLTAPRRAQRPHGGAEASGG- Cele_tag-93.AA DQECQPIPVVPRSSSSDELRVWRVTSAGLVEVDAKTMGAFLDKPKTDKTNVHG--EGNG- Aque_g24834.t1.AA ------------------------------------MGAFLEKPKTDKVTSSG--EGYG- Dmel_CG6036.AA --------------------------------MGHKMGGFLEKPETEKQAQEG--HGNG- Dmel_alph.AA ------------------------------------MGGFLDKPKTAKHNDEG--EGNK- Nvec_nvec_213347.AA ------------------------------------MGAFLDKPRTEKETKTG--EGNG- Spur_spur_hmm2044,hmm5714.AA ------------------------------------MGAFLEKPNTEKENERG--SGNG- Hsap_PPM1A.AA ------------------------------------MGAFLDKPKMEKHNAQG--QGNG- Hsap_PPM1B.AA ------------------------------------MGAFLDKPKTEKHNAHG--AGNG- Scer_PTC1.AA ---------------------------------YRVGVAENKNSKFRRTMEDVHT--YVK Ddis_DDB_G0284243.AA APSTPQVAHQTIQPQQAQSTHFTTEPSSKTRSVRDFGVSFEKNARYRRTMEDEHV---II Mbre_mbre_25189.AA ---------------------------------QKFGLAYMQG--WRAHMEDAHI--TQP Mbre_mbre_33662.AA ---------------------------------LSYALSSMQG--WRIHMEDAHA--VSA Mbre_mbre_33092.AA ---------------------------------LIWALSSMQG--WRVEMEDAHQ--AVT Hsap_PPM1N.AA ---------------------------------LRFGASAAQG--WRARMEDAHC--TWL Cele_tag-93.AA ---------------------------------IRYGMSSMQG--WRICMEDSHIAEAIM Aque_g24834.t1.AA ---------------------------------IRYAVSAMQG--WRMEMEDSHI--CDT Dmel_CG6036.AA ---------------------------------LRYCVSSMQG--WRLEMEDSHS--AAC Dmel_alph.AA ---------------------------------LLFGVSSMQG--WRSEMEDAYY--ARA Nvec_nvec_213347.AA ---------------------------------LRYGLAAMQG--WRVEMEDAHT--AVI Spur_spur_hmm2044,hmm5714.AA ---------------------------------LRYGLSSMQG--WRVEMEDAHS--AVT Hsap_PPM1A.AA ---------------------------------LRYGLSSMQG--WRVEMEDAHT--AVI Hsap_PPM1B.AA ---------------------------------LRYGLSSMQG--WRVEMEDAHT--AVV : :. :* *** : Scer_PTC1.AA NFASRL-DWGYFAVFDGHAGIQASKWCGKHLHTIIEQN----------------ILADET Ddis_DDB_G0284243.AA DCFGGDANQGYFAIYDGHGGRGAVEFTAKTLHVNLLDE----------------INKSPE Mbre_mbre_25189.AA ELPG-LPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYE--------------LLPVKDSL Mbre_mbre_33662.AA DLPN-LPNGALFAVFDGHGGKTVSTTAGEIFIQAITSTEAY------------TKGDKSA Mbre_mbre_33092.AA DIPE-LPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFK----------AAEDKLNP Hsap_PPM1N.AA SLPGLPPGWALFAVLDGHGGARAARFGARHLPGHVLQE--------------LGPEPSEP Cele_tag-93.AA SQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKTLEENNGVLTDSTL Aque_g24834.t1.AA DF---IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDE-------CKSTEEPK Dmel_CG6036.AA RLKDPFATWSYFAVFDGHAGSQISLHCAEHLMSTILESESF-----------------SK Dmel_alph.AA GLGDALPDWSFFAVFDGHAGCKVSEHCAKHLLESIISTEEFIG----------------- Nvec_nvec_213347.AA GLSDHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAAIK------ESSDSPDL Spur_spur_hmm2044,hmm5714.AA GLPHGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPKV-----DGKLNPST Hsap_PPM1A.AA GLPSGLESWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFK----------GSAGAPSV Hsap_PPM1B.AA GIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKS-----GSALELSV . :.: ***.* : Scer_PTC1.AA RDVRDVLNDSFLAIDEEINTKLVGNS-------GCTAAVCVLRWELPDSVSDDSMDLAQH Ddis_DDB_G0284243.AA GDILELFRNSYLLTDKQMNESEIQFS-------GTTSITALIRKNPVDG----------- Mbre_mbre_25189.AA HAISDAMHRAFLRHD---RALFADNKVRLDNS-GGTCTSVLVS----------------- Mbre_mbre_33662.AA ANLEQVLSKGLFELDEAIKEKHPQLKAGHDRS-GSTVICGFVT----------------- Mbre_mbre_33092.AA DMLKDAFRQGLLDLDASIRATNSDLDSCADRS-GSTAVGVIVT----------------- Hsap_PPM1N.AA EGVREALRRAFLSADERLRSLWPRVETG-----GCTAVVLLVS----------------- Cele_tag-93.AA KLLEKGIKKGFLSFDEISKTS-NDISKS-----GCTAVCAIVT----------------- Aque_g24834.t1.AA ERIKQAIYDGFLKLDSKIRED-PTWANGEDHS-GTTAITVMIS----------------- Dmel_CG6036.AA HKYEAGIREGFLQLDEDMRKL-YHDQQG-----GSTAICVFVS----------------- Dmel_alph.AA GDHVKGIRTGFLRIDEVMREL-PEFTRESEKCGGTTAVCAFVG----------------- Nvec_nvec_213347.AA DQLRSGLRDAFLELDSTMQKL-PKWSSGEDKS-GSTAIALLVT----------------- Spur_spur_hmm2044,hmm5714.AA DAVKEGIRTGFLSIDSKMRTD-FARTDSSDKS-GSTAVGVIIS----------------- Hsap_PPM1A.AA ENVKNGIRTGFLEIDEHMRVM-SEKKHGADRS-GSTAVGVLIS----------------- Hsap_PPM1B.AA ENVKNGIRTGFLKIDEYMRNF-SDLRNGMDRS-GSTAVGVMIS----------------- : . : * . * * .: Scer_PTC1.AA QRKLYTANVGDSRIVLFRNG--NSIRLTYDHKASDTLEMQRVEQAGGLIMKSRVNGMLAV Ddis_DDB_G0284243.AA EKYLYVANAGDARAVVCHNK--VAERLSYDHKGSDPEEVKRIDAAGGFVCNGRVNGILAV Mbre_mbre_25189.AA PTHYIFVNLGDSRSLLCRGG--KLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAI Mbre_mbre_33662.AA ETSVVLCNCGDSRAVLVSDG--KVKFATSDHKPSDEIETQRIKNAGGFIEMGRVCGNLAV Mbre_mbre_33092.AA PTHVIFGNCGDSRAFICRNG--NVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAV Hsap_PPM1N.AA PRFLYLAHCGDSRAVLSRAG--AVAFSTEDHRPLRPRERERIHAAGGTIRRRRVEGSLAV Cele_tag-93.AA PTHFIIGNLGDSRAVVAGK---NEIFGTEDHKPYLEKERKRIEGAGGSVMIQRINGSLAV Aque_g24834.t1.AA PTHIYWANCGDSRGFLCSDG--KVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAV Dmel_CG6036.AA PDKIYLVNCGDSRAVISRNG--AAVISTIDHKPFSPKEQERIQNAGGSVMIKRINGTLAV Dmel_alph.AA LTQVYIANCGDSRAVLCRQG--VPVFATQDHKPILPEEKERIYNAGGSVMIKRVNGTLAV Nvec_nvec_213347.AA PKYYIFANCGDSRGILSHNG--EVIYNTVDHKPGNPDEKTRIENAGGSVMIQRVNGALAV Spur_spur_hmm2044,hmm5714.AA PKHLFFANCGDSRSVLSRKGEDKPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAV Hsap_PPM1A.AA PQHTYFINCGDSRGLLCRNR--KVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAV Hsap_PPM1B.AA PKHIYFINCGDSRAVLYRNG--QVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAV : **:* .: : **. * *: *.* : *: * **: Scer_PTC1.AA TRSLGDKFF---------DSLVVGSPFTTSVEITSEDK-FLILACDGLWDVIDDQDACEL Ddis_DDB_G0284243.AA TRSLGDHSMKDH---------VIGDPYKRSIKLDSGHT-HLILACDGLWDVTSDQDAVDL Mbre_mbre_25189.AA SRAFGDFDYKRNPQLGALEQKVVADPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAIKF Mbre_mbre_33662.AA SRAIGDYEYKDRPDLKPEEQKVTALSDTTSISRTPKDE-FLVLACDGIWDVLTNEGVQLV Mbre_mbre_33092.AA SRSLGDYFYKDMPDLDATAQKISPEADMTVIERNPEDQ-FMLIACDGIYDVLTNANAAAF Hsap_PPM1N.AA SRALGDFTYKEAPGRPPELQLVSAEPEVAALARQAEDE-FMLLASDGVWDTVSGAALAGL Cele_tag-93.AA SRAFGDYEYKDDPRLPADQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEF Aque_g24834.t1.AA SRALGDFDYKRNNSIPAKEQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSY Dmel_CG6036.AA SRAFGDYDFKNDGSKSPVDQMVSPEPDIIVCNRSEHDE-FIVVACDGIWDVMTSSEVCEF Dmel_alph.AA SRALGDYDFKNVKEKGQCEQLVSPEPEIFCQSRQDSDE-FLVLACDGIWDVMSNEDVCSF Nvec_nvec_213347.AA SRALGDFEYKLDSSLHATKQLVSPEPDIFFQSRSDQDE-FIVLACDGVWDVMTNDEVGAF Spur_spur_hmm2044,hmm5714.AA SRALGDYDYKNNPDKPPTEQLVSPEPEVTVFERTDEEE-FIILACDGIWDVMSNEELCQF Hsap_PPM1A.AA SRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDF Hsap_PPM1B.AA SRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDE-FIILACDGIWDVMSNEELCEY :*::** : . .:::..**::*. . Scer_PTC1.AA IKDI-----TEPNEAAKVLVRYALENGTTDNVTVMVVFL--------------------- Ddis_DDB_G0284243.AA ILNE-----TEAQKMSDKLLLHALKKGSTDNISIIVVIL--------------------- Mbre_mbre_25189.AA VATKLRRSPDNPKAVCQALLKRCLELGSRDNMSACLVVFNKEFLQATHVSSAEERPAEQA Mbre_mbre_33662.AA VNFFLERG-YDAERIADLLLDYCLELGSKDNMSALLILFPGCRKPDPSLTKTA------- Mbre_mbre_33092.AA ITNQLKAG-YKAEEVVERLLDYCLHLDSKDNMSAILVLFENAPKPEEGFVAPEQFPDPA- Hsap_PPM1N.AA VASRLRLG-LAPELLCAQLLDTCLCKGSLDNMTCILVCFPGAPRPSEEAIRRELALDAA- Cele_tag-93.AA VKDRLSVH-SDLREVCDDVLDECLVKGSRDNMTMVVVCFPAAPEVNIHRKEAEEAWVSRV Aque_g24834.t1.AA VRRQLELT-ANLEKICNDLIDLCLNKNSRDNMSVVLVVFPNAPKVSQEAIEKEKILQKEA Dmel_CG6036.AA IRSRLLVT-YDLPMIVNSVLDICLHKGSRDNMTLLLLLLPGAPKVDMDAVKAERSLDQT- Dmel_alph.AA IHSRMRVT-SNLVSIANQVVDTCLHKGSRDNMSIIIIAFPGAPKPTEEAIEAEHRLEKQ- Nvec_nvec_213347.AA VRSRLQIT-DDLQRVSCELLDTCLTKGSRDNMSVIIISLPGSPKVTDEAIKNEQKVEAE- Spur_spur_hmm2044,hmm5714.AA IRSRLAIT-DNLEEICNQVIETCLQKGSRDNMSIVIVLFQNAPEVSQDALTKEKELDVL- Hsap_PPM1A.AA VRSRLEVT-DDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPEAVKKEAELDKY- Hsap_PPM1B.AA VKSRLEVS-DDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKH- : :: .* .: **:: :: : Scer_PTC1.AA ------------------------------------------------------------ Ddis_DDB_G0284243.AA ------------------------------------------------------------ Mbre_mbre_25189.AA LDGLATSVAFNAMASAVAEIVNQ----HGSPTSSRSASTSAAANGISPLREIPVFDMEEA Mbre_mbre_33662.AA ---------------ETEEARAT----ILEEQMMRLRQIV--ESTP----NVLPAGAIET Mbre_mbre_33092.AA ---------------ETFASSGNGDNGVAQPSPDNILQLLSS--------MMSNQGGVNV Hsap_PPM1N.AA ---LGCRIA------ELCASAQK------PPSLNTVFRTLASEDIP----DLPPGGGLDC Cele_tag-93.AA KTVINQFLD------EAVAAEDF----KQEEDMVTLKSILDKVTAN----GLLPTD-LRV Aque_g24834.t1.AA QEKIEEKLK------EMVKAAND----PLEVEENYILQQL----IQ----EFPDNYCVPA Dmel_CG6036.AA ---IVQITK------EVIEKHEI----HDFETLIRLMKRMA-INIP----NLPPGGGLYA Dmel_alph.AA ---IEKITR------DEIESSKI----TDYVDLLKCLQ--NRDDIE----GLPPGGGLQS Nvec_nvec_213347.AA ---LEAKLE------ALLEEETN----LAEVDVSYAMQSLSQEEIQ----GLPPGGGLAS Spur_spur_hmm2044,hmm5714.AA ---LEEKVK------EVMENFGD------QTQLDLVMHVLRMADIP----GLPPGGGLSA Hsap_PPM1A.AA ---LECRVE------EIIKKQGE-----GVPDLVHVMRTLASENIP----SLPPGGELAS Hsap_PPM1B.AA ---LESRVE------EIMEKSGE----EGMPDLAHVMRILSAENIP----NLPPGGGLAG Scer_PTC1.AA ------------------------------------------------------------ Ddis_DDB_G0284243.AA ------------------------------------------------------------ Mbre_mbre_25189.AA HPSGLHTVMEVCTCVH-------------------------------------------- Mbre_mbre_33662.AA SPMAASKASQMSSGTV-------------------------------------------- Mbre_mbre_33092.AA VRADDNGDSGAAAADT-------------------------------------------- Hsap_PPM1N.AA KATVIAEVYSQICQVS-------------------------------------------- Cele_tag-93.AA PEHTVTTLAQKILTQR-------------------------------------------- Aque_g24834.t1.AA KKSFISEHLQKLTKDKFGDLPDNFTGQSDSSNAPPDFQSDFKSILTADGNEIHISGVMEE Dmel_CG6036.AA KYYIIEQAFHEKFPDT-------------------------------------------- Dmel_alph.AA KYHVIERTFKQEFPDR-------------------------------------------- Nvec_nvec_213347.AA K----------------------------------------------------------- Spur_spur_hmm2044,hmm5714.AA KKGTIEEILNRLIPNR-------------------------------------------- Hsap_PPM1A.AA KRNVIEAVYNRLNPYK-------------------------------------------- Hsap_PPM1B.AA KRNVIEAVYSRLNPHRESDGASDEAEESGSQGKLVEALRQMRINHRGNYRQLLEEMLTSY Scer_PTC1.AA ------------------------------------------------------------ Ddis_DDB_G0284243.AA ------------------------------------------------------------ Mbre_mbre_25189.AA ------------------------------------------------VCSCVHRVCVLG Mbre_mbre_33662.AA ------------------------------------------------------------ Mbre_mbre_33092.AA ------------------------------------------------ADKQ-------- Hsap_PPM1N.AA ----------------------------------EECGEKGQDGAGKSNPTHLGSALDME Cele_tag-93.AA ------------------------------------------------DIKHV------- Aque_g24834.t1.AA DYPKDENLLQANDNSITEVTDETPTPDKEEEDEKMETTQDTTTTTDTLPKEDKDEKMEEE Dmel_CG6036.AA ------------------------------------------------PAEIYDYFSM-- Dmel_alph.AA ------------------------------------------------PCEGNGISYFIP Nvec_nvec_213347.AA ------------------------------------------------------------ Spur_spur_hmm2044,hmm5714.AA --------------------------------------------------KHDEDSADEK Hsap_PPM1A.AA ------------------------------------------------NDDTDSTSTDDM Hsap_PPM1B.AA RLAKVEGEESPAEPAATATSSNSDAGNPVTMQESHTESESGLAELDSSNEDAGTKMSGEK Scer_PTC1.AA ------ Ddis_DDB_G0284243.AA ------ Mbre_mbre_25189.AA WQ---- Mbre_mbre_33662.AA ------ Mbre_mbre_33092.AA ------ Hsap_PPM1N.AA A----- Cele_tag-93.AA ------ Aque_g24834.t1.AA GVKTTT Dmel_CG6036.AA ------ Dmel_alph.AA F----- Nvec_nvec_213347.AA ------ Spur_spur_hmm2044,hmm5714.AA W----- Hsap_PPM1A.AA W----- Hsap_PPM1B.AA I-----