CLUSTAL W (1.81) multiple sequence alignment Dmel_rdgC.AA -----------------------MDENAIRAAIFIQKWYRRHQARREMQRRCNWQIFQNL Hsap_PPEF1.AA MGCSSSSTKTR------------RSDTSLRAALIIQNWYRGYKARLKARQHYALTIFQSI Cele_pef-1.AA MGCGPSSGRQNP-----------STELTIKSAILIQKWYRRCEARLEARRRATWQIFTAL Hsap_PPEF2.AA MGSGTSTQHHFAFQ---------NAERAFKAAALIQRWYRRYVARLEMRRRCTWSIFQSI Nvec_nvec_239552.AA MGCGTSVDAYKEYDGHKNSLSLSKSEKALRSAVLIQNWFRRYRARLEARRRCTWKIFQSI Spur_Spur_hmm166550,hmm106875.AA ----------------------------------MLPW---------------------- Spur_Spur_hmm273834,hmm154013.AA MGCGNSMHAHSEMG---------KSERSLKAALLIQKWYRRYQARLEARRRCTWKIFQTI : * Dmel_rdgC.AA EYASEQDQAELYKFFNDLIKHMPQAA------------------------GRKNQYQGSA Hsap_PPEF1.AA EYADEQGQMQLSTFFSFMLENYTHIH-------------------KEELELRNQSLESEQ Cele_pef-1.AA EYAGEQDQLKLYDFFADVIRAMAEENGKGGVENGRNSPLMSALSHYAKPSLMDSEGETVK Hsap_PPEF2.AA EYAGQQDQVKLHDFFSYLMDHFIPSS--------------HNDRDFLTRIFTEDRFAQDS Nvec_nvec_239552.AA EYSGEQDQLKLFNFFTDMLTHVQPDN------TGASRANIIEDTLSRNGSASSTSSKSST Spur_Spur_hmm166550,hmm106875.AA ------------------------------------------------------------ Spur_Spur_hmm273834,hmm154013.AA EYAGEQDQLKLYNFFNSMMQTVSEDD-------------------SKSKYIIQGSNEGKT Dmel_rdgC.AA HVSVLDDKDDLVEEFGDIVNAKIELPIRKNHIDLLIDVFRKKRGNRLHPKYVALILREAA Hsap_PPEF1.AA DMRDRWDYVDSIDVPDSYNGPRLQFPLTCTDIDLLLEAFKEQQ--ILHAHYVLEVLFETK Cele_pef-1.AA KMLEDTSPTN-VDIDRNYKGPTLSLPLDKPQVAKMIEAFKVNK--VLHPKYVLMILHEAR Hsap_PPEF2.AA EMKKCSDYES-IEVPDSYTGPRLSFPLLPDHATALVEAFRLKQ--QLHARYVLNLLYETK Nvec_nvec_239552.AA TLEAATDPSD-IKVEPTYTGHVVKLPITLMSVRNIIEQCKLNK--LVHAKYVLLILREAR Spur_Spur_hmm166550,hmm106875.AA ------------------------------------------------------------ Spur_Spur_hmm273834,hmm154013.AA RDSDEDIYSD-MEVEEDYDGPHLAFPLSLDQVEKMMEDFKEQK--LLHSKYVLMVLRETE Dmel_rdgC.AA KSLKQLPNISPVSTAVSQQVTVCGDLHGKLDDLLVVLHKNGLPSSSNPYVFNGDFVDRGK Hsap_PPEF1.AA KVLKQMPNFTHIQTSPSKEVTICGDLHGKLDDLFLIFYKNGLPSERNPYVFNGDFVDRGK Cele_pef-1.AA KIFKAMPSVSRISTSISNQVTICGDLHGKFDDLCIILYKNGYPSVDNPYIFNGDFVDRGG Hsap_PPEF2.AA KHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFIFYKNGLPSPERSYVFNGDFVDRGK Nvec_nvec_239552.AA ERFRALPNVIRVTTRIAKQMTICGDLHGKLDDLFMIFHKNGLPSPENPYIFNGDLVDRGP Spur_Spur_hmm166550,hmm106875.AA -----------ITSVIARKVKYC-----------FIIFQNGLPSAENPYIFNGDYVDRGM Spur_Spur_hmm273834,hmm154013.AA KVMKTKKNINRATTAIAKQITVCGDLHGAIEDLFLVFYKNGLPSAENPYIFNGDYVDRGM : : ::. * .::.:** ** ..*:**** **** Dmel_rdgC.AA RGLEVLLLLLSLYLAFPNAVFLNRGNHEDSVMNARYGFIREVESKY---PRNHKRILAFI Hsap_PPEF1.AA NSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLRYGFTKEILHKY---KLHGKRILQIL Cele_pef-1.AA QSIEVLCVLFALVIVDPMSIYLNRGNHEDHIMNLRYGFIKELSTKY---KDLSTPITRLL Hsap_PPEF2.AA DSVEILMILFAFMLVYPKEFHLNRGNHEDHMVNLRYGFTKEVMNKY---KVHGKEILRTL Nvec_nvec_239552.AA RSIEICIILFAFTILYPNGVYINRGNHEDHIMNLRYGFVKEVMDKY---KDHASKIIRLF Spur_Spur_hmm166550,hmm106875.AA HSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKYGAQRSHAQKIIGQF Spur_Spur_hmm273834,hmm154013.AA HSVEIAIILFCFFLLFPNEVYLNRGNHEDYILNLRYGFLKEVQSKY------GAQIIGQF .:*: :* : * ..:******* ::* **** .*: ** * : Dmel_rdgC.AA DEVYRWLPLGSVLNSRVLIVHGGFSDSTSLDLIKSIDRGKYVSILRPP-LTDGEPL---- Hsap_PPEF1.AA EEFYAWLPIGTIVDNEILVIHGGISETTDLNLLHRVERNKMKSVLIPPTETNRDHDTDSK Cele_pef-1.AA EDVFSWLPIATIIDRDIFVVHGGISDQTEVSKLDKIPRHRFQSVLRPP-VNKGMESEKEN Hsap_PPEF2.AA QDVFCWLPLATLIDEKVLILHGGVSDITDLELLDKIERSKIVSTMRCKTRQKSEKQMEEK Nvec_nvec_239552.AA EDIFGWLPLATIVNNKIFVAHGGISNITDLDIIERIDRHKYVSVLKPPNIVKDNPSLS-- Spur_Spur_hmm166550,hmm106875.AA QDLFAWLPLATLIDSKILICHGGISDKTDLTFLDNIARHKYLSVLKPP-LKEGAEETS-- Spur_Spur_hmm273834,hmm154013.AA QDLFAWLPLATLIDSKILICHGGISDKTDLTFLDNIARHKYLSVLKPP-LKEGAEELTGE ::.: ***:.:::: ::: ***.*: *.: : : * . * : . Dmel_rdgC.AA ------------------------------------------------------------ Hsap_PPEF1.AA H----------------------------------------------------------- Cele_pef-1.AA S----------------------------------------------------------- Hsap_PPEF2.AA RRANQKSSAQGPIPWFLPESRSLPSSPLRLGSYKAQKTSRSSSIPCSGSLDGRELSRQVR Nvec_nvec_239552.AA ------------------------------------------------------------ Spur_Spur_hmm166550,hmm106875.AA ------------------------------------------------------------ Spur_Spur_hmm273834,hmm154013.AA E----------------------------------------------------------- Dmel_rdgC.AA ------------------------------------------DKTEWQQIFDIMWSDPQA Hsap_PPEF1.AA -------------------NKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRG Cele_pef-1.AA -------------------AV---------------------NVDEWKQMLDIMWSDPKQ Hsap_PPEF2.AA SSVELELERCRQQAGLLVTGEKEEPSRSASEADSEAGELRKPTQEEWRQVVDILWSDPMA Nvec_nvec_239552.AA ------------------------------------------SLKEWRQVLDLLWSDPKP Spur_Spur_hmm166550,hmm106875.AA ------------------------------------------NISFFVQILDILWSDPRS Spur_Spur_hmm273834,hmm154013.AA -------------------ED----------------LSLKIDLSEWRQILDILWSDPRS : *:.*::**** Dmel_rdgC.AA TMGCVPNTLRGAGVWFGPDVTDNFLQRHRLSYVIRSHECKPNGHEFMHDNKIITIFSASN Hsap_PPEF1.AA KNGCFPNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASN Cele_pef-1.AA NKGCWPNVFRGGGSYFGADITASFLEKHGFRLLVRSHECKFEGYEFSHNNTCLTVFSASN Hsap_PPEF2.AA QEGCKANTIRGGGCYFGPDVTQQLLQKYNMQFLIRSHECKPEGYEFCHNRKVLTIFSASN Nvec_nvec_239552.AA TPGCKPNTFRGGGCYFGPDVTSQVLRKHNFELLVRSHECKYEGYEYMHNKKVITIFSASN Spur_Spur_hmm166550,hmm106875.AA QDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASN Spur_Spur_hmm273834,hmm154013.AA QDGCQPNTFRGGGSYFGPDVTKKVLAKHGIDLLIRSHECKPDGYEFTHGDKVLTVFSASN ** .*. **.* :**.*:* ..* .: : ::****** :*:* *. . :*:***** Dmel_rdgC.AA YYAIGSNKGAYIRL-NNQLMPHFVQYISAASQTKRLSFKQRMGIVESSALKELAVRMRDH Hsap_PPEF1.AA YYEEGSNRGAYIKL-CSGTTPRFFQYQVT-KATCFQPLRQRVDTMENSAIKILRERVISR Cele_pef-1.AA YYETGSNRGAYVKFIGKSKQPHFVQYMAS-KTHRKSTLRERLGVVEESAVKELKEKLSSF Hsap_PPEF2.AA YYEVGSNRGAYVKL-GPALTPHIVQYQAN-KVTHTLTMRQRISRVEESALRALREKLFAH Nvec_nvec_239552.AA YYEQGSNRGAYMKI-GPDMTPYFVQYQVS-RTKKHLTLKQRVGIVEESAIRELKEKLYAN Spur_Spur_hmm166550,hmm106875.AA YYEEGSNRGAYIKF-GTDLKPRCFQYQTSAKNTKKMTMRQKVSIVEESALRDLREKIGAN Spur_Spur_hmm273834,hmm154013.AA YYEEGSNRGAYIKF-GTDLKPRCFQYQTSAKNTKKMTMRQKVSIVEESALRDLREKIGAN ** ***.***:.: * .** .:.:.:. :*.**:. * .: Dmel_rdgC.AA RDELEDEFRKYDPKDSGYISISHWCKVMENVTKLGLPWRLLRDK---------------- Hsap_PPEF1.AA KSDLTRAFQLQDHRKSGKLSVSQWAFCMENILGLNLPWRSLSSN---------------- Cele_pef-1.AA HTDLQKEFEIMDIEKSGKLPILKWSDCVERITGLNLPWIALAPK---------------- Hsap_PPEF2.AA SSDLLSEFKKHDADKVGLITLSDWAAAVESVLHLGLPWRMLRPQ---------------- Nvec_nvec_239552.AA KSALMEAFTKRDEQHTGYLTCSQWAAAIESTLHLDVPWNMLRHQ---------------- Spur_Spur_hmm166550,hmm106875.AA TTYLRQAFQKYDPGNTGFITSTQWARTMEEILDLSIPWRTLKTKMCRMNENGLIEYDSCL Spur_Spur_hmm273834,hmm154013.AA TTYLRQAFQKYDPGNTGFITSTQWARTMEEILDLSIPWRTLKTK-------------PYL * * * * :. *. :* *.:** * : Dmel_rdgC.AA ------------------------------------------------------------ Hsap_PPEF1.AA ------------------------------------------------------------ Cele_pef-1.AA ------------------------------------------------------------ Hsap_PPEF2.AA ------------------------------------------------------------ Nvec_nvec_239552.AA ------------------------------------------------------------ Spur_Spur_hmm166550,hmm106875.AA EMELQYSGEKGGPSVTETLYRNKNALETIFRVMDKDHSGWFICVASITKNSIAYLICITS Spur_Spur_hmm273834,hmm154013.AA SLSLRFHH---------------------INPVGQDYGG-------------------DP Dmel_rdgC.AA -----------------------LAPGTDSQKVNYNRTLDLLDTDVILEAEADGMSVMDA Hsap_PPEF1.AA -----------------------LVNIDQNGNVEYMSSFQNIRIEKPVQ-EA-HSTLVET Cele_pef-1.AA -----------------------VATLSEDG--KYVMYKEDRRIAQVGGTHAQEKDIVES Hsap_PPEF2.AA -----------------------LVNSSADNMLEYKSWLKNLAKEQLSR-ENIQSSLLET Nvec_nvec_239552.AA -----------------------LAYVAPDGKVDYRSCLEQYAIEGKTK-KN-GPSITEA Spur_Spur_hmm166550,hmm106875.AA TQWARTMEEILDLSIPWRTLKTKMCRMNENGLIEYDSCLEM-ELQYSGE-KG-GPSVTET Spur_Spur_hmm273834,hmm154013.AA RPWARTMEEILDLSIPWRTLKTKMCRMNENGLIEYDSCLEM-ELQYSGE-KG-GPSVTET : . .* . : :: Dmel_rdgC.AA LYANKASLVAIFNIIDADNSGEITLDEFETAIDLLVAHMPGAYSKAEMLEKCRMMDLNGD Hsap_PPEF1.AA LYRYRSDLEIIFNAIDTDHSGLISVEEFRAMWKLFSSHYNVHIDDSQVNKLANIMDLNKD Cele_pef-1.AA LYRHKSTLETLFRFMDKDNSGQVSMKEFIDACEVLGKYTKRPLQTDYISQIAESIDFNKD Hsap_PPEF2.AA LYRNRSNLETIFRIIDSDHSGFISLDEFRQTWKLFSSHMNIDITDDCICDLARSIDFNKD Nvec_nvec_239552.AA LYRNRSNLETIFRLMDKDNSGHVSMEEFQASCRLLNQHSETEIPEDSIQDLARSIDMDKD Spur_Spur_hmm166550,hmm106875.AA LYRNKNALETIFRVMDKDHS---------------------------------------- Spur_Spur_hmm273834,hmm154013.AA LYRNKNALETIFRVMDKDHSGCISMEEFQDACQLLSKHIGSNIPPETVKDMAQSIDINKD ** . * :*. :* *:* Dmel_rdgC.AA GKVDLNEFLEAFRLSDLHRKEQQDENIRRRSTGRPSVAKTATDPVTLLADKISKNTLVVE Hsap_PPEF1.AA GSIDFNEFLKAFYVVHRYEDLMKPDVTNLG------------------------------ Cele_pef-1.AA GFIDLNELLEAFRLVDRPLLR--------------------------------------- Hsap_PPEF2.AA GHIDINEFLEAFRLVEKSCPEGDASECPQATNAKDS------------------------ Nvec_nvec_239552.AA GYIDFNEFLEAFRLVDVSKSQNGPTHTPRSSQNSSA------------------------ Spur_Spur_hmm166550,hmm106875.AA ------------------------------------------------------------ Spur_Spur_hmm273834,hmm154013.AA GNIDFNEFLEAFRLVDTQDIKLDGQTSMQNSPAHVA------------------------ Dmel_rdgC.AA HDIDPTDCESKVIDPKKS Hsap_PPEF1.AA ------------------ Cele_pef-1.AA ------------------ Hsap_PPEF2.AA ------GCSSPGAH---- Nvec_nvec_239552.AA ------RSSPVNSIHITS Spur_Spur_hmm166550,hmm106875.AA ------------------ Spur_Spur_hmm273834,hmm154013.AA ------NGENNKV-----