CLUSTAL W (1.81) multiple sequence alignment Scer_PTC7.AA ---MFANV-GFRTLRVSRGPLYGSC---------------SQIISFSKRTFY---SSAKS Ddis_DDB_G0280067.AA -MNQFKLVNSIIKETLTKSSNSVLLKSSQKNCKVSSGTINNNIFRNSKFTTSNLTLTTST Dmel_fig.AA ---MITCLRNWPLLL-------------------------KRFSVHQIHQFT-----QLS Cele_W09D10.4.AA MVAGVRLL-AY-----------------------------GRLAVRAVFSASALDLGSTI Nvec_nvec_150220.AA -MAMQTCI-VY-----------------------------GRFFCTQARQAV-----TQM Nvec_nvec_230062.AA -MAMQTCI-VY-----------------------------GRFFCTQARQAV-----TQM Hsap_PPTC7.AA ---MFSVL-SY-----------------------------GRLVARAVLGGL-----SQT Dmel_CG15035.AA -MDVETSL-DIEEMRRRIQQGINRCCEQLLEIAMILTHKGGQVLNRLKGASF-----PEL Dmel_CG12091.AA ---MHSSL-SWT----------------------------SRAISRALRSSF-----STL : . Scer_PTC7.AA GYQSNNS-------------------------------------HGDAYSSGSQSG---- Ddis_DDB_G0280067.AA TLNTKNSIFNFEQNKKTLGCLLFTTTFLFNSTTTNNDSIKTFCTNTTTTTTTTTTNNNNN Dmel_fig.AA GRFERPP-------------------------------------QSGKSSRD-------- Cele_W09D10.4.AA GPEAISS-------------------------------------GRRGLSSGSSKP---- Nvec_nvec_150220.AA VRKEAPS-------------------------------------K--------------- Nvec_nvec_230062.AA VRKEAPS-------------------------------------K--------------- Hsap_PPTC7.AA DPRAGGG-------------------------------------GGGDYG---------- Dmel_CG15035.AA AQNSENI-------------------------------------GNGSMSENQNQRLDPM Dmel_CG12091.AA LETATGG-------------------------------------GSGAAAKGATKS---- Scer_PTC7.AA ------------------------------PFTYKTAVAFQPKDRDDLIYQK-------- Ddis_DDB_G0280067.AA NSNINIMIDTMTINDASAASTSSTVAEDCLSTTIDATATITDTTTNHKTYVDEAMQDREM Dmel_fig.AA ------------------------------PYLVTVVQGRSKKPRFPGER---------- Cele_W09D10.4.AA -------------KPSSEGSPSSPAPSAHVENVIASCAGFPKDMLNGPSTVL-------- Nvec_nvec_150220.AA ------------------------------VRLVAVCCGFSKDY--HTSK---------- Nvec_nvec_230062.AA ------------------------------VRLVAVCCGFSKDY--HTSK---------- Hsap_PPTC7.AA --------------------------------LVTAGCGFGKDFRKGLLK---------- Dmel_CG15035.AA TSAQYTTLGFGNFDGEGDYLRQKNKINIQLPRLVSVTCGFAKDHIRYPEY---------- Dmel_CG12091.AA ----------GATPGSSGAPR---------PRFVSVVCGFAKDNLRH-KY---------- Scer_PTC7.AA ------------------------------------------------------------ Ddis_DDB_G0280067.AA RDQNNNSNDDSTDEINNIDKNKSNNIDKEEQEQEEEEEEDNTNTNITSDDDETNQIINNI Dmel_fig.AA ------------------------------------------------------------ Cele_W09D10.4.AA ------------------------------------------------------------ Nvec_nvec_150220.AA ------------------------------------------------------------ Nvec_nvec_230062.AA ------------------------------------------------------------ Hsap_PPTC7.AA ------------------------------------------------------------ Dmel_CG15035.AA ------------------------------------------------------------ Dmel_CG12091.AA ------------------------------------------------------------ Scer_PTC7.AA ---------------------------LKDSIRSPTGEDNYFVTSNNVHDIFAGVADGVG Ddis_DDB_G0280067.AA NNINNYNSEECIGGEGNFHLNSGVCVIPHPNKRHKGGEDAYFISIDQ--NVI-GVADGVG Dmel_fig.AA -------------------------------SNQRFGEDSWFVSSTPLAEVM-GVADGVG Cele_W09D10.4.AA -------------------------------DKGVFGDDAWFISRFKNTFVV-GVADGVG Nvec_nvec_150220.AA -------------------------------KRFAFGEDAYFITENLFSNVL-AVA-CMS Nvec_nvec_230062.AA -------------------------------KRFAFGEDAYFITENLFSNVL-GVADGVG Hsap_PPTC7.AA -------------------------------KGACYGDDACFVARHRSADVL-GVADGVG Dmel_CG15035.AA -------------------------------NRGKFGEDAWFMSSSPQACIM-GVADGVG Dmel_CG12091.AA -------------------------------KPGKYGEDSWFKASTASADVM-GVADGVG *:* * : :. .** :. Scer_PTC7.AA GWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAAYAKIRDEKVVKVGG Ddis_DDB_G0280067.AA GWGDVGIDPSEYSNTLMKGS-KIGA-----DSQKVERDPLIIMEQGYQYAQDVK----GS Dmel_fig.AA GWRDLGVDAGRFAKELMSCCSGQTQ-----LSDFDGRSPRNMLIAGFQELSHREHPVVGS Cele_W09D10.4.AA GWRKYGIDPSAFSRRLMKECEKRVQ-----KGDFDPQKPESLLDYAFRASAEAPRPV-GS Nvec_nvec_150220.AA CCRTFFLLKLVAGSTSIKGVSRKLK-INFLDGRTCRMTTQQTMKTRIQPLLMFFFSRTGS Nvec_nvec_230062.AA GWRQYGIDSSLFSSQLMQSCQRFVK-----EGRLSALSPIAIIKNAFQELTELKASVFGS Hsap_PPTC7.AA GWRDYGVDPSQFSGTLMRTCERLVK-----EGRFVPSNPIGILTTSYCELLQNKVPLLGS Dmel_CG15035.AA GWRNYGVDPGKFSMTLMRSCERMSH-----APDFKPNRPEILLERAYFDLLDQKCPIVGS Dmel_CG12091.AA GWRSYGIDPGEFSSFLMRTCERLVQ-----CSHFNPQRPVNLLAYSYCELMEQKKPILGS . . : *. Scer_PTC7.AA TTAIVAHFPSNG-KLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLKE Ddis_DDB_G0280067.AA STCCIVVLSATN-NILSANLGDSGFLVIRNNEVIFRTREQQHAFNMPFQL---------- Dmel_fig.AA STACLATMHRKDCTLYTANLGDSGFLVVRNGRVLHRSVEQTHDFNTPYQLTVPPED---- Cele_W09D10.4.AA STACVLVVHQE--KLYSANLGDSGFMVVRNGKIVSKSREQVHYFNAPFQLTLPPEG---- Nvec_nvec_150220.AA STACIVVLDKRDKTLHSVNLGDSGFLVVRKGIVVHQSSEQQHYFNTPYQLAIPPPG---- Nvec_nvec_230062.AA STACIVVLDKKDKTLLSVNLGDSGFLVVRKGIVVHQSSEQQHYFNTPYQLAIPPPG---- Hsap_PPTC7.AA STACIVVLDRTSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPE---- Dmel_CG15035.AA CTACILALKRDDSTLYAANIGDSGFLVVRSGKVVCRSQEQQHQFNTPYQLASPPPG---- Dmel_CG12091.AA STACVLILNRETSTVHTANIGDSGFVVVREGQVVHKSEEQQHYFNTPFQLSLPPPG---- *. : . : .*:*** *.* . :: .: * ** *:** Scer_PTC7.AA AERRGSKYILNTPRDADEYSFQLKKKDIIILATDGVTDNIATDDIELFLKDNAA-RTNDE Ddis_DDB_G0280067.AA -----GTQSIDRPIHSITASFPAEKGDLIIMGTDGVFDNLFDDEILEI-----G-EKYDD Dmel_fig.AA ---RKESYYCDKPEMAVSTRHSLLPGDLVLLATDGLFDNMPESMLLSILNGLKE-RGEHD Cele_W09D10.4.AA ---YQG-FIGDKADMADKDEMAVKKGDIILLATDGVWDNLSEQQVLDQLKALDA--GKSN Nvec_nvec_150220.AA ---QDGRVIQDSLDAAESTSFNVEVDDLIVMGTDGLFDNLSTDQILTEIAELQD-YDAES Nvec_nvec_230062.AA ---QDGRVIQDSLDAAESTSFNVEVDDLIVMGTDGLFDNLSTDQILTEIAELQD-YDAES Hsap_PPTC7.AA ---AEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQELKKLKN-SNYES Dmel_CG15035.AA ---YDFDAVSDGPESADTIQFPMQLGDVILLATDGVYDNVPESFLVEVLTEMSGISNPVR Dmel_CG12091.AA ---HGPNVLSDSPESADTMSFPVRDGDVILIATDGVFDNVPEDLMLQVLSEVEGERDPVK : : *::: .***: **: : Scer_PTC7.AA LQLLSQKFVDNVVSLSKDPNYPSVFAQEISKLTGKNYS-GGKEDDITVVVVRVD------ Ddis_DDB_G0280067.AA PQIIARQVAKRAFEVGCSTTIYTPFAKN-AGHNGYIYN-GGKLDDITVVVGLVDDGPLRP Dmel_fig.AA LLVGASRVVEKARELSMNASFQSPFAIK-ARQHNVSYSGGGKPDDITLILSSVEVPNA-- Cele_W09D10.4.AA VQEVCNALALTARRLAFDSKHNSPFAMK-AREHGFLAP-GGKPDDITLVLLLIA------ Nvec_nvec_150220.AA IQSLADSLAMKARCLAFDPSYESPFAKQ-AKLRGLAIT-GGKPDDITVLVAVVSEESSKE Nvec_nvec_230062.AA IQSLADSLAMKARCLAFDPSYESPFAKQ-AKLRGLAIT-GGKPDDITVLVAVVSEESSKE Hsap_PPTC7.AA IQQTARSIAEQAHELAYDPNYMSPFAQF-ACDNGLNVR-GGKPDDITVLLSIVAEYTD-- Dmel_CG15035.AA LQMAANTVALMARTLSFSPKHDSPFSQN-ARKHDIDAW-GGKPDDITVLLASVV------ Dmel_CG12091.AA LQMTANSLALMARTLSLNSEFLSPFALS-ARRNNIQAR-GGKPDDITVVLATVAM----- . .. . :. .. : *: : . *** ****::: : Scer_PTC7.AA -------------- Ddis_DDB_G0280067.AA VKPDLLLLDEEVAQ Dmel_fig.AA -------------- Cele_W09D10.4.AA -------------- Nvec_nvec_150220.AA TEV----------- Nvec_nvec_230062.AA TEV----------- Hsap_PPTC7.AA -------------- Dmel_CG15035.AA -------------- Dmel_CG12091.AA --------------