CLUSTAL W (1.81) multiple sequence alignment Scer_TEP1.AA.PD_43-251 -DISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYK Ddis_DDB_G0275865.AA.PD_113-213 ----------------------------------------------------------F- Ddis_DDB_G0292920.AA.PD_86-196 ----------------------------------------------------------V- Ddis_cnrN.AA.PD_77-185 -------------------------------------------------SERVYDYSKL- Cele_daf-18.AA.PD_126-228 ----------------------------------------------------------F- Ddis_DDB_G0285967.AA.PD_81-182 ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA.PD_523-626 ----------------------------------------------------------F- Dmel_Pten.AA.PD_92-336 ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA.PD_84-181 ------------------------------------------------------------ Nvec_nvec_PTEN.AA.PD_80-182 ----------------------------------------------------------F- Aque_aque_PTEN.AA.PD_81-183 ----------------------------------------------------------K- Spur_spur_PTEN-A.AA.PD_47-149 ----------------------------------------------------------F- Hsap_PTEN.AA.PD_23-183 LDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF- Spur_spur_PTEN-B.AA.PD_74-176 ----------------------------------------------------------F- Scer_TEP1.AA.PD_43-251 DNDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIGWLD Ddis_DDB_G0275865.AA.PD_113-213 ---------------------------GGRVHHIGCV----------------------D Ddis_DDB_G0292920.AA.PD_86-196 ---------------------------GGNVIVMGFE----------------------D Ddis_cnrN.AA.PD_77-185 ---------------------------NNQILEFPFL----------------------D Cele_daf-18.AA.PD_126-228 ---------------------------DGNVICFDMT----------------------D Ddis_DDB_G0285967.AA.PD_81-182 ---------------------------EDRVSEYPFD----------------------D Mbre_mbre_PTEN-A.AA.PD_523-626 ---------------------------HNRVGVYPFD----------------------D Dmel_Pten.AA.PD_92-336 -----------------------------RVAVYPFD----------------------D Mbre_mbre_PTEN-B.AA.PD_84-181 -----------------------------RVAKYPFD----------------------D Nvec_nvec_PTEN.AA.PD_80-182 ---------------------------HNRVATYPFD----------------------D Aque_aque_PTEN.AA.PD_81-183 ---------------------------FHKVTVYPFD----------------------D Spur_spur_PTEN-A.AA.PD_47-149 ---------------------------DHRVAHYPFD----------------------D Hsap_PTEN.AA.PD_23-183 ---------------------------NCRVAQYPFE----------------------D Spur_spur_PTEN-B.AA.PD_74-176 ---------------------------YNRVAHYPFD----------------------D .: * Scer_TEP1.AA.PD_43-251 HFPPPFELLEEIVDGIENYLSVSK-NRVAVLHCRMGKGRSGMITVAYLMKYLQCPLG--- Ddis_DDB_G0275865.AA.PD_113-213 NHSPSLGLLLYAVQVIHKWLSEDP-KNVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKE-- Ddis_DDB_G0292920.AA.PD_86-196 HTPPPFLLLLDIIETMNKWLDSDE-QNVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLF Ddis_cnrN.AA.PD_77-185 HHPPPLSLLFEIVNSLSNWLKADA-ENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMD-- Cele_daf-18.AA.PD_126-228 HHPPSLELMAPFCREAKEWLEADD-KHVIAVHCKAGKGRTGVMICALLIYINFYPSPR-- Ddis_DDB_G0285967.AA.PD_81-182 HCPPTLNIISEFCNDMEMWLDQNP-ENVVAVHCKAGKGRTGTMLACWLLYNKQCQTGS-- Mbre_mbre_PTEN-A.AA.PD_523-626 HNPAPLPLVLACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGICPDPD-- Dmel_Pten.AA.PD_92-336 HNPPTIELIQRFCSDVDMWLKEDS-SNVVAVHCKAGKGRTGTMICAYLVFSGIKKSAD-- Mbre_mbre_PTEN-B.AA.PD_84-181 HNAPPFLLMQPFCEDVHQYLSEDS-RNVAVIHCKAGKGRTGVMISAYLMHCGLFEKTE-- Nvec_nvec_PTEN.AA.PD_80-182 HNAPPFELIKPFCDDVDEWLKASN-LNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTK-- Aque_aque_PTEN.AA.PD_81-183 HNPPPFELIQPFCEDVDGWLKEDN-RNVAVIHCKAGKGRTGVMICSYLLHDRLFDTVK-- Spur_spur_PTEN-A.AA.PD_47-149 HNPPRIELIRPFCEDVMQWLAEDK-DNVAAIHCKAGKGRTGVMICALLLHQGRCLTAA-- Hsap_PTEN.AA.PD_23-183 HNPPQLELIKPFCEDLDQWLSEDD-NHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQ-- Spur_spur_PTEN-B.AA.PD_74-176 HNPPRLELIKPFCEDLDNWLGADG-QNVAAIHCKAGKGRTGVMICAYMLHRRLYQTAS-- : .. : :: :* . .* :** * **:* : . : Scer_TEP1.AA.PD_43-251 --------EARLIFMQARFKYGMTNGVTIPSQLRYLRYHEFF------------------ Ddis_DDB_G0275865.AA.PD_113-213 --------EALQLFASQRTTSK--VGVKVPSQLRYIDYVHQL------------------ Ddis_DDB_G0292920.AA.PD_86-196 YSSDTILYNTISFFNQMRANNS--ECVTVPSQKRYVGYYIQY------------------ Ddis_cnrN.AA.PD_77-185 --------DAKNHFAEKRSKMK--KGVTQPSQQRYINYFKE------------------- Cele_daf-18.AA.PD_126-228 --------QILDYYSIIRTKNN--KGVTIPSQRRYIYYYHKLRE---------------- Ddis_DDB_G0285967.AA.PD_81-182 --------ESMRLFANKRTHNS--KGVTIPSQIRYVRYFEALLQ---------------- Mbre_mbre_PTEN-A.AA.PD_523-626 --------SAMTMFGAKRTHNG--KGVTIPSQRRYIRYFHTMLQ---------------- Dmel_Pten.AA.PD_92-336 --------EALAWYDEKRTKDR--KGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIR Mbre_mbre_PTEN-B.AA.PD_84-181 --------EALEFYGHARTMNG--KGVTIPSQVRYVHYYGRY------------------ Nvec_nvec_PTEN.AA.PD_80-182 --------EAMEYYGNARTRNA--KGVTIPSQRRYVEYYGYLLR---------------- Aque_aque_PTEN.AA.PD_81-183 --------DALQFYGEARTQNA--KGVTIPSQRRYVQYYGHLIR---------------- Spur_spur_PTEN-A.AA.PD_47-149 --------ESMEYYGKIRTTDG--KGVTIPSQRRYVQYYGELVK---------------- Hsap_PTEN.AA.PD_23-183 --------EALDFYGEVRTRDK--KGVTIPSQRRYVYYYSYLLK---------------- Spur_spur_PTEN-B.AA.PD_74-176 --------EALDFYASKRTKNR--KGVTIPSQRRYVEYYGNLIV---------------- . : * *. *** **: * Scer_TEP1.AA.PD_43-251 ------------------------------------------------------------ Ddis_DDB_G0275865.AA.PD_113-213 ------------------------------------------------------------ Ddis_DDB_G0292920.AA.PD_86-196 ------------------------------------------------------------ Ddis_cnrN.AA.PD_77-185 ------------------------------------------------------------ Cele_daf-18.AA.PD_126-228 ------------------------------------------------------------ Ddis_DDB_G0285967.AA.PD_81-182 ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA.PD_523-626 ------------------------------------------------------------ Dmel_Pten.AA.PD_92-336 FSESSCVQNLGMVECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKF Mbre_mbre_PTEN-B.AA.PD_84-181 ------------------------------------------------------------ Nvec_nvec_PTEN.AA.PD_80-182 ------------------------------------------------------------ Aque_aque_PTEN.AA.PD_81-183 ------------------------------------------------------------ Spur_spur_PTEN-A.AA.PD_47-149 ------------------------------------------------------------ Hsap_PTEN.AA.PD_23-183 ------------------------------------------------------------ Spur_spur_PTEN-B.AA.PD_74-176 ------------------------------------------------------------ Scer_TEP1.AA.PD_43-251 ------------------------------------------------------------ Ddis_DDB_G0275865.AA.PD_113-213 ------------------------------------------------------------ Ddis_DDB_G0292920.AA.PD_86-196 ------------------------------------------------------------ Ddis_cnrN.AA.PD_77-185 ------------------------------------------------------------ Cele_daf-18.AA.PD_126-228 ------------------------------------------------------------ Ddis_DDB_G0285967.AA.PD_81-182 ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA.PD_523-626 ------------------------------------------------------------ Dmel_Pten.AA.PD_92-336 ELTKKSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEE Mbre_mbre_PTEN-B.AA.PD_84-181 ------------------------------------------------------------ Nvec_nvec_PTEN.AA.PD_80-182 ------------------------------------------------------------ Aque_aque_PTEN.AA.PD_81-183 ------------------------------------------------------------ Spur_spur_PTEN-A.AA.PD_47-149 ------------------------------------------------------------ Hsap_PTEN.AA.PD_23-183 ------------------------------------------------------------ Spur_spur_PTEN-B.AA.PD_74-176 ------------------------------------------------------------ Scer_TEP1.AA.PD_43-251 --------- Ddis_DDB_G0275865.AA.PD_113-213 --------- Ddis_DDB_G0292920.AA.PD_86-196 --------- Ddis_cnrN.AA.PD_77-185 --------- Cele_daf-18.AA.PD_126-228 --------- Ddis_DDB_G0285967.AA.PD_81-182 --------- Mbre_mbre_PTEN-A.AA.PD_523-626 --------- Dmel_Pten.AA.PD_92-336 FKISIVFEA Mbre_mbre_PTEN-B.AA.PD_84-181 --------- Nvec_nvec_PTEN.AA.PD_80-182 --------- Aque_aque_PTEN.AA.PD_81-183 --------- Spur_spur_PTEN-A.AA.PD_47-149 --------- Hsap_PTEN.AA.PD_23-183 --------- Spur_spur_PTEN-B.AA.PD_74-176 ---------