CLUSTAL W (1.81) multiple sequence alignment Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA ------------------------------------------------------------ Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA ------------------------------------------------------------ Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA ------------------------------------------------------------ Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA MAAAGGEEALPVAPADMSDSLRLLEDAIDHYRHRHEACLAQSAGGEADPSAITVNVHPDV Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA ------------------------------------------------------------ Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA ------------------------------------------------------------ Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA ------------------------------------------------------------ Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA QVQLNREDESTVRLANGTVIQHRYACLDRRVSFPTVLLLLSLYRIDCSSRIVNLASTRQS Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA ------------------------------------------------------------ Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA ------------------------------------------------------------ Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA ------------------------------------------------------------ Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA LSHRSLPSSFNGTKIVSLPDGTVVEILLDGTRYIRNARTGTILTETADGAQSVSNPAQTP Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA ----------------------------------------------MVTPPPDVPSTSTR Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA ------------------------------------------------------------ Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA ------------------------------------------------------------ Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA LHKPEKRVGFGSLAPLLEKQQMYASTTNNAEHTGTAQSPALDSTTNASASPSPSPSKGTT Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------MREEGSELEMEKGFLKWKP----------------------------- Ddis_DDB_G0275865.AA --MDFLKKLNQDLIKKSNELGEEINKQVNST----------------------------- Cele_daf-18.AA SMARDLQENPNRQPGEPRVSEPYHNSIVERI----------------------------- Ddis_DDB_G0292920.AA -------------------------MSDGSG----------------------------- Ddis_DDB_G0289979.AA --------------------------MYNSI----------------------------- Ddis_cnrN.AA --------------------------MNQVF----------------------------- Ddis_DDB_G0285967.AA ------------------------------------------------------------ Dmel_Pten.AA -----------------------MANTISLM----------------------------- Mbre_mbre_PTEN-A.AA ASASAMDRSAVEEPDEDQDASLDEPDSEDDVDSSSDEEEIDRKPSLPDAASAASVVEHDN Ddis_pten.AA ------------------------------M----------------------------- Mbre_mbre_PTEN-B.AA ------------------------------M----------------------------- Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA -----------------------------MA----------------------------- Hsap_PTEN.AA ------------------------------M----------------------------- Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA ------------------------------------------------------------ Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA ------------------------------------------------------------ Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA ------------------------------------------------------------ Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA VIHQGWLFKEGGQIRSWRRRYFVLQSNGLLVYFPDAPQASGRNSTPINAIDVVGAEVTQS Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA ------------------------------------------------------------ Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA ------------------------------------------------------------ Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA ------------------------------------------------------------ Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA TSSKRPHGFIVASDQSAKRRSSATNKREKYVLAGSSDADRDAWMARIRYCAALDSQSLDG Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA -----------------------VNLMKKILSLPM--KKTKND-IGLRLDISYILVNLIV Ddis_DDB_G0275865.AA -----------------------VLKIRTQVSENNTTIRFKDG--EFDLDLSYITERIIA Cele_daf-18.AA -----------------------RHIFRTAVSSNR--CRTEYQ--NIDLDCAYITDRIIA Ddis_DDB_G0292920.AA -----------------------FDYFRTIVSGRK--KRFIQD--GFNLDLSYITERILA Ddis_DDB_G0289979.AA -----------------------VKAVRKTISADK--NRYENE--EYDLDLTYITERVIA Ddis_cnrN.AA -----------------------FSKIRSLVSADR--HRFKSKEMDLDLDLSYITDNILA Ddis_DDB_G0285967.AA -----------------------MDLVRKMVSKKK--RRFEMY--NFDLDLSYITDRVIA Dmel_Pten.AA -----------------------SNVIRNVVSKKR--IRYKEK--GYDLDLTYINDNIIA Mbre_mbre_PTEN-A.AA TILPVAQHSLASRFTNFARGINASNKVRQLVSKQK--IRFQKD--GFDLDLTYITPNIVA Ddis_pten.AA -----------------------SNLLRVAVSKQK--RRYQKN--GYDLDLAYITDNIVA Mbre_mbre_PTEN-B.AA -----------------------ATIAKHLVSKKK--RRFMDE--GFDLDLTFITRNIVA Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA -----------------------MSYFKQLVSKKK--RRFQED--GFDLDLTYIKPNIVA Aque_aque_PTEN.AA -----------------------TNKFRHLVSKRK--RRFIAD--GFDLDMTFIKPNIVA Hsap_PTEN.AA -----------------------TAIIKEIVSRNK--RRYQED--GFDLDLTYIYPNIIA Spur_spur_PTEN-B.AA -----------------------------MVSKKK--RRFIDK--GFDLDLSYIYPNIIA Scer_TEP1.AA CSYPVNTYP--KLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAK Ddis_DDB_G0275865.AA MSFPSEDTVINSTWYRNSRVDVKKMLDKYH-RDHYLIINL-TEK---------------S Cele_daf-18.AA IGYPA-TGI--EANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGY---------------Y Ddis_DDB_G0292920.AA MGYPA-DSI--HKAFRNDINEVYNFFEKYH-SAHWKILNVAMEI---------------S Ddis_DDB_G0289979.AA MSFPA-DGV--ESAYRNSIYDVSKLLNTSH-KDHYLIYNL-SER---------------K Ddis_cnrN.AA MGFPG-TGL--EASWRNSIDDVCELLKQKH-HGKYMIWNL-SER---------------V Ddis_DDB_G0285967.AA MGFPS-ESL--EGLYRNRMRDVQRFFNTLH-ADHYKVYNLCSER---------------K Dmel_Pten.AA MGYPAPDKL--EGLFRNRLEDVFKLLEENH-AQHYKIYNLCSER---------------S Mbre_mbre_PTEN-A.AA MGYPA-EGT--EAVYRNRYEDTLRFLEERH-PGAYRVYNLCSER---------------A Ddis_pten.AA MGFPS-EKV--EGVFRNPMKDVQRFLDQYH-KDHFKVYNLCSER---------------V Mbre_mbre_PTEN-B.AA MGFPA-EGR--EGIYRNHMRDVKRFFDYRC-KDHYRVYNLCSER---------------D Spur_spur_PTEN-A.AA MGFPA-ESL--ERMYRNDMEHVVKFLNSHH-QDHYKVYNLCSER---------------N Nvec_nvec_PTEN.AA MGFPS-EKL--EGVYRNHMDEVYRFLEQKH-KDSYKVYNLCSER---------------Q Aque_aque_PTEN.AA MGFPS-EKL--EGVYRNKMSDVQRYFDTHY-TDHYKVYNLCSER---------------F Hsap_PTEN.AA MGFPA-ERL--EGVYRNNIDDVVRFLDSKH-KNHYKIYNLCAER---------------H Spur_spur_PTEN-B.AA MGFPA-ESL--EGVYRNKLEVVVKFFNEKH-GERYKVYNLCSER---------------N .:* :** : : *. Scer_TEP1.AA FESKDFEIQELRSTLINDGKIPIS-PIDLETRTLVEEETNNVICERIGWLDHFPPPFELL Ddis_DDB_G0275865.AA YDSSFF-----------GGRVHHI-GCV----------------------DNHSPSLGLL Cele_daf-18.AA YDADNF-----------DGNVICF-DMT----------------------DHHPPSLELM Ddis_DDB_G0292920.AA YSTTKV-----------GGNVIVM-GFE----------------------DHTPPPFLLL Ddis_DDB_G0289979.AA YDYSLF-----------NGMVLDWCGFP----------------------DHHAPPLGLL Ddis_cnrN.AA YDYSKL-----------NNQILEF-PFL----------------------DHHPPPLSLL Ddis_DDB_G0285967.AA YEHCRF-----------EDRVSEY-PFD----------------------DHCPPTLNII Dmel_Pten.AA YDVAKF-----------RGRVAVY-PFD----------------------DHNPPTIELI Mbre_mbre_PTEN-A.AA YPPSRF-----------HNRVGVY-PFD----------------------DHNPAPLPLV Ddis_pten.AA YDHSKF-----------YGRVGYY-PFD----------------------DHNAPQFEMI Mbre_mbre_PTEN-B.AA YDPQKF-----------YGRVAKY-PFD----------------------DHNAPPFLLM Spur_spur_PTEN-A.AA YDTSRF-----------DHRVAHY-PFD----------------------DHNPPRIELI Nvec_nvec_PTEN.AA YDPMRF-----------HNRVATY-PFD----------------------DHNAPPFELI Aque_aque_PTEN.AA YDPKKF-----------H-KVTVY-PFD----------------------DHNPPPFELI Hsap_PTEN.AA YDTAKF-----------NCRVAQY-PFE----------------------DHNPPQLELI Spur_spur_PTEN-B.AA YDTTKF-----------YNRVAHY-PFD----------------------DHNPPRLELI : . : *: .. : :: Scer_TEP1.AA EEIVDGIENYLSVSKN-RVAVLHCRMGKGRSGMITVAYLMKYLQCPLGE----------A Ddis_DDB_G0275865.AA LYAVQVIHKWLSEDPK-NVVAIHCLAGLGRSGTLIVAYLLTSLYEGRKE----------E Cele_daf-18.AA APFCREAKEWLEADDK-HVIAVHCKAGKGRTGVMICALLIYINFYPSPR----------Q Ddis_DDB_G0292920.AA LDIIETMNKWLDSDEQ-NVIAVHCKAGKGRTGTVISSYLINQMKRTTPDLFYSSDTILYN Ddis_DDB_G0289979.AA FKIVMTIYSWLEKDPM-NVVVVHCMAGKGRTGTVISALLQYGGLFEGAS----------D Ddis_cnrN.AA FEIVNSLSNWLKADAE-NVAVVHCKGGKGRTGTIICCYLYYSCQFEIMD----------D Ddis_DDB_G0285967.AA SEFCNDMEMWLDQNPE-NVVAVHCKAGKGRTGTMLACWLLYNKQCQTGS----------E Dmel_Pten.AA QRFCSDVDMWLKEDSS-NVVAVHCKAGKGRTGTMICAYLVFSGIKKSAD----------E Mbre_mbre_PTEN-A.AA LACCADIHAWLAANPERNVAAIHCKAGKGRTGLIISCYLMYAGICPDPD----------S Ddis_pten.AA DAFCRDVDAWMKEDSK-NIAVIHCKAGKGRTGLMICCWLMYCGMWKNTE----------D Mbre_mbre_PTEN-B.AA QPFCEDVHQYLSEDSR-NVAVIHCKAGKGRTGVMISAYLMHCGLFEKTE----------E Spur_spur_PTEN-A.AA RPFCEDVMQWLAEDKD-NVAAIHCKAGKGRTGVMICALLLHQGRCLTAA----------E Nvec_nvec_PTEN.AA KPFCDDVDEWLKASNL-NVAIIHCKAGKGRTGVMICAYLLHNGHFKDTK----------E Aque_aque_PTEN.AA QPFCEDVDGWLKEDNR-NVAVIHCKAGKGRTGVMICSYLLHDRLFDTVK----------D Hsap_PTEN.AA KPFCEDLDQWLSEDDN-HVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQ----------E Spur_spur_PTEN-B.AA KPFCEDLDNWLGADGQ-NVAAIHCKAGKGRTGVMICAYMLHRRLYQTAS----------E :: . .: :** * **:* : . : Scer_TEP1.AA RLIFMQARFKYGMTNGVTIPSQLRYLRYHEFFIT--HEKAAQE---GISNEAVKFKF--- Ddis_DDB_G0275865.AA ALQLFASQ-RTTSKVGVKVPSQLRYIDYVHQLVTSQRPVDVVQNPMKLRLNAIMIKPSP- Cele_daf-18.AA ILDYYSII-RTKNNKGVTIPSQRRYIYYYHKLRE--RELNYLP-L-RMQLIGVYVERPPK Ddis_DDB_G0292920.AA TISFFNQM-RANNSECVTVPSQKRYVGYYIQYLR--DQVTHASLLSPAQFKILNIDVIG- Ddis_DDB_G0289979.AA AMRYFAVK-RSNNNYGITGPSQIRYTQYFSDIYF--GGKELNP-G-PVFLKSISMVTLP- Ddis_cnrN.AA AKNHFAEK-RSKMKKGVTQPSQQRYINYFKEIVS--GSHMVEE-F-VLTFRSIELGPLTK Ddis_DDB_G0285967.AA SMRLFANK-RTHNSKGVTIPSQIRYVRYFEALLQYGKPIPKPPSI-TKVLSMIKMNSLP- Dmel_Pten.AA ALAWYDEK-RTKDRKGVTIPSQRRYVQYFSKLVC--SSVPYSK-V-SLNVCEIRFSESS- Mbre_mbre_PTEN-A.AA AMTMFGAK-RTHNGKGVTIPSQRRYIRYFHTMLQ--GDRTVPPAT-PLTLTGIRLHGVP- Ddis_pten.AA SLRFYAAL-RTYNQKGVTIPSQIRYVGYFGRSIR--ESIKYVP-R-NVTLKKIVLRPLPK Mbre_mbre_PTEN-B.AA ALEFYGHA-RTMNGKGVTIPSQVRYVHYYGRYVR--EQREFEP-I-PLIMKRIILHGIP- Spur_spur_PTEN-A.AA SMEYYGKI-RTTDGKGVTIPSQRRYVQYYGELVK--RNTLYKT-Q-TVLLKRVQLYTIP- Nvec_nvec_PTEN.AA AMEYYGNA-RTRNAKGVTIPSQRRYVEYYGYLLR--NCLTYVP-T-MVLLRGFEIITIP- Aque_aque_PTEN.AA ALQFYGEA-RTQNAKGVTIPSQRRYVQYYGHLIR--NNLQYSP-R-TILLHAIRLEGIP- Hsap_PTEN.AA ALDFYGEV-RTRDKKGVTIPSQRRYVYYYSYLLK--NHLDYRP-V-ALLFHKMMFETIP- Spur_spur_PTEN-B.AA ALDFYASK-RTKNRKGVTIPSQRRYVEYYGNLIV--RELEYKP-T-TLLLTRIDLETVP- . :. *** ** * . . Scer_TEP1.AA ---------KFRLA----KMTFLRPSSLITSESAIVT--TKIQHYNDDRNALLTRKVVYS Ddis_DDB_G0275865.AA ---------VVS------GKSGQVWKPTIEI-FNVMKPLEPHLLFSTKDLDGPFNKNQ-- Cele_daf-18.AA TWGGGSKI-KVEVGN---GSTILFKPDPLIISKSNHQ--RERATWLNNCDTPNEFDTGEQ Ddis_DDB_G0292920.AA ---------LYT------STQTPHFNIEIHLNYNPKI--RNLPIIIRGSNTGIVF----- Ddis_DDB_G0289979.AA ---------KFFLGPLKQGVCPVLNI------YSATQ--KGVRIFTSAPIEGDTKETRTY Ddis_cnrN.AA DQANSLSFEIFEHA----KEPILN--------FASSSNSIQIVPINNDNSESNNNNNNNN Ddis_DDB_G0285967.AA ---------NFNIG----GGCEPY--------LSIVQ--QGKSVFYSKPVKLKK------ Dmel_Pten.AA --------------------CVQN--------LGMVE--CSISVLHDSATENAKPDRLKT Mbre_mbre_PTEN-A.AA ---------NYDFS----GGCQPY--------YQVYQ--EGVLIFSSKPAELRQLQAYK- Ddis_pten.AA EINLSEVQFNIS-V----GKNCVFNSKEHNMNVVISK--KKKTVVDKNKKDPKKKLTKEN Mbre_mbre_PTEN-B.AA ---------DFK-D----GTCVPQ--------FTLRHGPQHVLTFKSGWYEGISR----- Spur_spur_PTEN-A.AA ---------MMS-S----GTCCPF--------FTVHQ--HKVKIHTQEAVKGVKK----- Nvec_nvec_PTEN.AA ---------NMQ-G----GNCCPF--------YIIWQ--YKVKIHTSKLIESSKK----- Aque_aque_PTEN.AA ---------NFS-G----GTCAPF--------FIVRK--HKVVLYTSKVYESIRR----- Hsap_PTEN.AA ---------MFS-G----GTCNPQ--------FVVCQ--LKVKIYSSNSGPTRR------ Spur_spur_PTEN-B.AA ---------MFN-G----GSCAPA--------FVIYQ--QKVKIFSSQPYEVAK------ Scer_TEP1.AA DIMAHE------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA KYHGFVS----------------------------------------------------- Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA ------------------------------------------------------------ Ddis_cnrN.AA NNNNNNNNQ--------------------------------------------------- Ddis_DDB_G0285967.AA ------------------------------------------------------------ Dmel_Pten.AA LPIDF------------------------------------------------------- Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA SEKNIDSQQQQQSQSSLSQSQQGQSSPNMQSLSASGTISSGSNVGTVNGNTLHQLGGSQF Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------CGGNMT-----FIFGRDYLTLENDCRIEFTLG----------TSKSKA Ddis_DDB_G0275865.AA ------------NDAFCKVQGDVVIIETQSLVLQGDVLVKIYHGFSDILSKEVLNVIMDK Cele_daf-18.AA ------------KRAYCF-----MVPEDAPVFVEGDVRIDIREI---------GFLKKFS Ddis_DDB_G0292920.AA ------------YQDFYS-----YILREKGIIAKGDTLIKFNSL--------------DS Ddis_DDB_G0289979.AA ------------QSGNAT-----IVFEV-RKIVRGDILLVFSHI-----TPFYRVEQICR Ddis_cnrN.AA ------------QQQLYK-----IIILI-QKKVQNDVLIRVYRG-----DTGKGKGKMKK Ddis_DDB_G0285967.AA ------------GTIHQQ-----VELDCGNILLVNDVQIQFFNR--------------NS Dmel_Pten.AA ------------QKSFV------LTIKP-SIPVSGDVKFELTKK--------------SP Mbre_mbre_PTEN-A.AA ------------RQTHRD-----IRFSC-NMAIEGNIRIELWDC--------DRGFHSEE Ddis_pten.AA SLSDLADGNTIGNDEYIS-----FEIG--ALSLAGDIRIEFTNK-----Q--------DD Mbre_mbre_PTEN-B.AA ------------EQGTAT-----LELKP-HTPVCGDVKLEFIHR---------KGSSGKE Spur_spur_PTEN-A.AA ------------GLSCVE-----FELPH-ALPIRDDVKIEFYHK---------SGLLKMD Nvec_nvec_PTEN.AA ------------GDTSIK-----LELSQ-PLPICGDIKVEFFHK---------DTFGRKE Aque_aque_PTEN.AA ------------TDAFAE-----LMLTK-PIPLCDDIKVEFYHN-----PRFGSKASYTE Hsap_PTEN.AA ------------EDKFMY-----FEFPQ-PLPVCGDIKVEFFHK--------QNKMLKKD Spur_spur_PTEN-B.AA ------------KERSVR-----CEFPL-PVPICGDIKIEFFNK---------PNKLKKD .: . . Scer_TEP1.AA ASSIIS----WTSCASC------------------------------------------- Ddis_DDB_G0275865.AA P--SLR---LAFHTSFIDN----------------------------------------- Cele_daf-18.AA DGKIGH---VWFNTMFACDGGLNGGHFEYVDKTQPYIGDDTSIGRKNGMRRNETPMRKID Ddis_DDB_G0292920.AA PQCVFR---FLFHTSFLLTPT--------------------------------------- Ddis_DDB_G0289979.AA A--NFHTGMFSFPTLILTKSDLDGADGDKRFSSDFHLRLDFQEVVNQNQQQQQQLLNSNN Ddis_cnrN.AA Q--IFH---LIFNIAFVNLDQCLFGM---------------------------------- Ddis_DDB_G0285967.AA KGHMFS---YCFHTAFIEGTKIHIRRQEIDKAHKDLKHFHSNFSIELIFLEDDRDDDSSS Dmel_Pten.AA DKIICH---FWLNTFFVRN----------------------------------------- Mbre_mbre_PTEN-A.AA K--MFA---ATFFTGMVEGTS--------------------------------------- Ddis_pten.AA R--MFM---FWVNTSFVQ------------------------------------------ Mbre_mbre_PTEN-B.AA K--MFH---LWFNTFFIVN----------------------------------------- Spur_spur_PTEN-A.AA KRLMFH---MWFNTYFIVHPIQP------------------------------------- Nvec_nvec_PTEN.AA R--MFQ---FWFNTFFISTGA--------------------------------------- Aque_aque_PTEN.AA K--MFL---FWFNTFFVDW----------------------------------------- Hsap_PTEN.AA K--MFH---FWVNTFFIPGPE--------------------------------------- Spur_spur_PTEN-B.AA R--MFH---FWFNTFFVANSNLL------------------------------------- Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA PETGNEFESPWQIVNPPGLEKHITEEQAMENYTNYGMIPPRYTISKILHEKHEKGIVKDD Ddis_DDB_G0292920.AA --------------------------------------TQDSQSI--------------- Ddis_DDB_G0289979.AA GDLTPYIIPANAQTSIEYQKEIKKEIKWIRHEAIAKKDHRNGSIFFLPSNNSEKIKQAKD Ddis_cnrN.AA --------------------------NEFDHFKSSKKYDPNLQMEC--------RFQNNC Ddis_DDB_G0285967.AA VSEESVEEKRVFNTSYATGLAKLYHNSNSNNKSLTSSTSSTSNLSSSTNNTFEIISNNNN Dmel_Pten.AA ----------------------------------YSPCESDGTVNK-------------- Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA --------------------------DKDYFGQARSHSRPTSTVSCPSPDQARAPFAEDE Nvec_nvec_PTEN.AA ------------------------------NMTDSREGEPTIHTFKESRNSDV------- Aque_aque_PTEN.AA --------------------------HVMQQEAQNAMATNSLSVSWLYTASHF------- Hsap_PTEN.AA --------------------------ETSEKVENGSLCDQEIDSICSI-----------E Spur_spur_PTEN-B.AA --------------------------NSSSQQDLANNGSSDNSSHCSEDNMEALDADC-- Scer_TEP1.AA --------------------------------------WLNIYLETLMHI--IKDDSS-- Ddis_DDB_G0275865.AA -------------------------------------HCLDLNRSTLDEK--DNCIQS-- Cele_daf-18.AA YNDRKLPMGDKSYTESGKSGDIRGVGGPFEIPYKAEEHVLTFPVYEMDRALKSKDLNNGM Ddis_DDB_G0292920.AA -------------------------------------ITLYFQKDNLDGG--SGGAFLD- Ddis_DDB_G0289979.AA TASKQGTFGVHSGYLFKKGHNFKSW----------RRRWFVLKDNILSYY--KSPKDTAP Ddis_cnrN.AA TGAPDHSF-----------------------------KIWNIMALQYQRT--KSSLNNSI Ddis_DDB_G0285967.AA NNNNNNNN-----------------------------NNINSNNNKINDE--NSNKNNNN Dmel_Pten.AA -------------------------------------YIHTLSKSEIDDV--HKDSEH-- Mbre_mbre_PTEN-A.AA ---------------------------------------LRMVRQELDGA--HKKKHL-- Ddis_pten.AA -------------------------------------QLEIIPKSGLDKA--HKDKNH-- Mbre_mbre_PTEN-B.AA -------------------------------------NRFYAAQSEVDKA--NKDKKN-- Spur_spur_PTEN-A.AA MLNGGEE------------------------------FVLELHKDEIDKA--NKDKTN-- Nvec_nvec_PTEN.AA -------------------------------------RWFAIPKQFVDKA--HKDNKC-- Aque_aque_PTEN.AA -------------------------------------RVVILPKNEIDKA--NKDKKH-- Hsap_PTEN.AA RADNDKEY-----------------------------LVLTLTKNDLDKA--NKDKAN-- Spur_spur_PTEN-B.AA -------------------------------------TVLRLQKDQLDRA--NKDKTN-- Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA KLHVVLRCVDTRDSKMMEKSEVFGNLAFHNESTRRLQALTQMNPKWRPEPCAFGSKGAEM Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA AGIIPINEIVNIEIECEISQAEGYDYCFQISTSKANYLISAENERDLEDWTEILRSAKRM Ddis_cnrN.AA TDIKSINEINSTNNNNILASSAPTPLTTTTTTTTTTTTTSLPSS---------------- Ddis_DDB_G0285967.AA NNIINNNSFSAWGNNSKIVKNRGSKLAFICPKCNLPITATDPSINRNSENYHWKCVVCVK Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA HYPPSVRYSSNDGKYNGACSENLVSDFFEHRNIAVLNRYCRYFYKQRSTSR--------- Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA VQSTGRLFIEILEVKYQPNMILADRSFINNPQPNGVLPLPIKMLDINDHPIDIITYVTVH Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA CSKPLGGESDCVFENNEMLCTDCGTEFFKSCSGCNLVIKTSDFEELGDHIYHRSCFLCYY Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ----------------------PDY----------------------------------- Ddis_DDB_G0275865.AA ------------------DKFSQDFSLR-------------------------------- Cele_daf-18.AA ------------------SRYPRKFRYC-------------------------------- Ddis_DDB_G0292920.AA ------------------SKYKTDFAIR-------------------------------- Ddis_DDB_G0289979.AA LGKKRDTTSHKSVLYNPVFMYAGDFPIY------DDEPSDL------------------- Ddis_cnrN.AA ------------------EHSTPQILIS-------------------------------- Ddis_DDB_G0285967.AA CTSYLGGKDFIVENINNIRRFKCSSCIDNKNRQNGDDDDNNNNDNIENILENKIPEICDK Dmel_Pten.AA ------------------KRFSEEFKIS-------------------------------- Mbre_mbre_PTEN-A.AA ------------------KMFEPQFAME-------------------------------- Ddis_pten.AA ------------------KAFPEDFHVE-------------------------------- Mbre_mbre_PTEN-B.AA ------------------KIYPEGFAIE-------------------------------- Spur_spur_PTEN-A.AA ------------------KVFSPNLKVK-------------------------------- Nvec_nvec_PTEN.AA ------------------KVFSPDFKVS-------------------------------- Aque_aque_PTEN.AA ------------------KQYPCNFKVH-------------------------------- Hsap_PTEN.AA ------------------RYFSPNFKVK-------------------------------- Spur_spur_PTEN-B.AA ------------------KWYSPNFKVI-------------------------------- Scer_TEP1.AA ---------------------------FQVERLKRDEMLGT------------------- Ddis_DDB_G0275865.AA ---------------------------LLFSPYQEQQQQPQPLQ---------------- Cele_daf-18.AA ----------------------PLIKKHFYIPADTDDVDENGQPFFHSPEHYIKEQEKID Ddis_DDB_G0292920.AA ---------------------------VLLEPILSNNISNNNNYNN-------------- Ddis_DDB_G0289979.AA -------VVSLWVRSSVQNIKDTLAAEFILKHNQLTNKYNTDWRDFNRIKSNLLSKMSLK Ddis_cnrN.AA ----------------------SSDANLDLKNCNINCDSSSGGGSN-------------- Ddis_DDB_G0285967.AA LDKEIIKLVIEIDKSTEPSPVSSIDPSMIFNDLEDNGKRRQMTVESMICSKCELAINQSR Dmel_Pten.AA ---------------------------IVFEAENFSNDVQA------------------- Mbre_mbre_PTEN-A.AA ---------------------------LTFKS---------------------------- Ddis_pten.AA ---------------------------LTFDQLDQQQSHTTVVASA-------------- Mbre_mbre_PTEN-B.AA ---------------------------ILFDNPEGNAKTSSPLAAN-------------- Spur_spur_PTEN-A.AA ---------------------------LFFARGREDQVPPT------------------- Nvec_nvec_PTEN.AA ---------------------------NVF------------------------------ Aque_aque_PTEN.AA ---------------------------MVLSEADNPGFSLD------------------- Hsap_PTEN.AA ---------------------------LYFTKTVEEPSNPE------------------- Spur_spur_PTEN-B.AA ---------------------------CYFKRVENEKPRRP------------------- Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA AEKAAKGIENTGPSTSGSSAPGTIKKTEASQSDKVKPATEDELPPARLPDNVR------- Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA IGMAYGSEVDIQLSEIAKGSSQQQQQQSSSSLSASPSSSPHTSTNYLNNKPHVSFNHS-- Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA PIILDCGIYHRECFQCSECFDETPMDPSLYYIRNDKPVCFDCDVNHIMNEAHSEITCYGC Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA ------------------------------------------------------------ Cele_daf-18.AA ------------------------------------------------------------ Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA ------------------------------------------------------------ Ddis_cnrN.AA ------------------------------------------------------------ Ddis_DDB_G0285967.AA KLPIVDEVMMDALNFKWHVACLVCSKCAIQIEGQLGDHQGLIYCKDHFEELVGTKCDQCN Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA -----------------------------------PLQPQQYQPANYQLPQQFQQPQQQQ Cele_daf-18.AA --------------------------RFPVVGVDFENPEEESCEHKTVESIAGFEPLEHL Ddis_DDB_G0292920.AA ---------------------------------NNNNNNNSIENNNGVVLRKAPLPPVIS Ddis_DDB_G0289979.AA -------IYNNSNILSANSNS-----ISLSNSLNFNTTPSSSTTTTTTTATNSNVSTSLP Ddis_cnrN.AA --------------------------SSRNSNSNSRGGSSNSSSNRSSTSSRSSITTDSI Ddis_DDB_G0285967.AA QYIDGMFLKVNGKNLCPTCFRCFCCNEVLEGGKYFEKNGESICEKCRNEDILKRKTQIHI Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA --------------------------EEQTNNQHYPQSSNNVATSSSHHDNITVVASDAP Mbre_mbre_PTEN-B.AA ---------------------------------------------------SLSASTASA Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA QPQHFQQSQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQYQPPQQ-SQPQ---- Cele_daf-18.AA FHESYHPNTAGNMLRQDYHTDSEVKIAEQEAKAFVDQLLNGQGVLQEFMKQ-FKVPSDNS Ddis_DDB_G0292920.AA NNTNFFDNNNNNNNSFNNSNNNNFNININNCNGNSIQPHVQQAPPPPVPCR-SKKP---- Ddis_DDB_G0289979.AA QPSTIYLAKSREENKINNLNSSNNSNTSVNSNLSRDPLTGLPTVNNNNGKQ-NESN---- Ddis_cnrN.AA KPSCSSDSICNNSSICNNSCNNNNNNNNNNNNNNNNNNNNNNNNNNNKNSN-NNNN---- Ddis_DDB_G0285967.AA QHTLITSLKNSQQISEKSSSSLSTSSTTTTTTTNNVVSSTSSTSTSPSTSP-SNSPLSSS Dmel_Pten.AA ------------EASEKERNENVLNFERSDYDSLSPNCYAEKKVLTAIVND-NTTK---- Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA QNNNNNNNLNSSNSNNATTTTTKNNISLASSQSNPVQQESNPSTTTQVSEE-NSAP---- Mbre_mbre_PTEN-B.AA QGMVPTASDGSDPAIPATSRGGQPMLPSRGPDASGEPLSAIPGKLTHRDSNVSQAP---- Spur_spur_PTEN-A.AA -------------------------------------PEPSEGNLSPSQSENDLLD---- Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA -------------------------------------HYCEEDLESQTDEQ-PDDP---- Hsap_PTEN.AA --------------------------------------ASSSTSVTPDVSD-NEPD---- Spur_spur_PTEN-B.AA ---------------------------------------SGDSNDRSSGTS-SDHE---- Scer_TEP1.AA ---------------------TISWQELDGFGELST------------------------ Ddis_DDB_G0275865.AA ---------------------HFQQQPPPQYQPPQQYQPPQQYQQPQPYQPQPQQYQQQQ Cele_daf-18.AA FADYVTGQAEVFKAQIALLEQSEDFQRVQANAEEVDLEHTLGEAFERFGHVVEESNGSSK Ddis_DDB_G0292920.AA ---------------------IYSYEPYEL------------------------------ Ddis_DDB_G0289979.AA ---------------------KFGYNPYDEDDEDK-----------LIEALQSQLNDTED Ddis_cnrN.AA ---------------------ESSSNSNDDSDSEASIRKRKNTLWSSGSSIKLKPSPNLS Ddis_DDB_G0285967.AA IQKDAPLFCLNKSRSLFRNSIKIHLEDLKNSGERK------TLLYPSFHRQMRKQTFKTA Dmel_Pten.AA ---------------------SQTIETLDHKDIVV------------------------- Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA ---------------------KVEAEKIENSNASA------------------------- Mbre_mbre_PTEN-B.AA ---------------------EFSDSDLTTTDEDD------------------------- Spur_spur_PTEN-A.AA ---------------------DQDLDDGTDSGDED------------------------- Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ---------------------HHGEENLSDTDPEDD------------------------ Hsap_PTEN.AA ---------------------HYRYSDTTDSDPEN------------------------- Spur_spur_PTEN-B.AA ---------------------HSDGGDISETDSE-------------------------- Scer_TEP1.AA ------------------------------------------------------------ Ddis_DDB_G0275865.AA PP---------------------------------------------------------- Cele_daf-18.AA NPKALKTREQMVKETGKDTQKTRNHVLLHLEANHRVQIERRETCPELHPEDKIPRIAHFS Ddis_DDB_G0292920.AA ------------------------------------------------------------ Ddis_DDB_G0289979.AA DEDLLLSTLKNKLDDFDDEDGGDDY------------------------NNNNSTTRVLE Ddis_cnrN.AA RLSLFNGHRQSFTKKINPNNNEENV------------------------DQKTLPILKKE Ddis_DDB_G0285967.AA YPSLRGTRRKDFLNHSKNELDSSNN------------------------SLSTLVNAFVP Dmel_Pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-A.AA ------------------------------------------------------------ Ddis_pten.AA ------------------------------------------------------------ Mbre_mbre_PTEN-B.AA ------------------------------------------------------------ Spur_spur_PTEN-A.AA ------------------------------------------------------------ Nvec_nvec_PTEN.AA ------------------------------------------------------------ Aque_aque_PTEN.AA ------------------------------------------------------------ Hsap_PTEN.AA ------------------------------------------------------------ Spur_spur_PTEN-B.AA ------------------------------------------------------------ Scer_TEP1.AA -HGLKLFQALKLEWEII Ddis_DDB_G0275865.AA -QQQSPNLQKQNNQYNM Cele_daf-18.AA ENSFSDSNFDQAIYL-- Ddis_DDB_G0292920.AA ----------------- Ddis_DDB_G0289979.AA DDNISEFEEIRDSQNSN Ddis_cnrN.AA TNDPSESDIKNVEIIQD Ddis_DDB_G0285967.AA PQQSNNSNTTTTTNTST Dmel_Pten.AA -NQHTCNQCLLRTYNSW Mbre_mbre_PTEN-A.AA ----------------- Ddis_pten.AA -NDSETSSNSSS----- Mbre_mbre_PTEN-B.AA -DEWEGLPISDV----- Spur_spur_PTEN-A.AA -CIYETSESSVV----- Nvec_nvec_PTEN.AA ----------------- Aque_aque_PTEN.AA -ENWEEVESVAV----- Hsap_PTEN.AA -EPFDEDQHTQITKV-- Spur_spur_PTEN-B.AA -SEWDVTEITHV-----