CLUSTAL W (1.81) multiple sequence alignment Spur_Spur_PTPRG.AA LLCASCSYAATIIAFRGQTARLPCNAFLHMQARVDPNTVMVSWTEMEMPFDLVNSTYMQ- Dmel_Ptp99A.AA ------------------MPRPQHHALLRAMLKLLLFASIAEHCATALPT---------- Hsap_PTPRG.AA ------------------MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENR Hsap_PTPRZ1.AA ---------------------------MRILKRFLACIQLLCVCRLDWANGYYR------ .. . Spur_Spur_PTPRG.AA -------NGRYSLDITDYSLLLDSASPHTDNRTFRCLARGIANPASLTTTTAGLTVGITQ Dmel_Ptp99A.AA -------NSSNSPSSPS-PFTAASLPPTTASSS---SSPAVISTSSSDRNLADLVNPEAE Hsap_PTPRG.AA HGSAVQIRRRKASGDPYWAYSGAYGPEHWVTSSVSCGGRH-QSPIDILDQYARVGEEYQE Hsap_PTPRZ1.AA -------QQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPK-QSPINIDEDLTQVNVNLKK . . . . .. . : : : Spur_Spur_PTPRG.AA ATLTTKADPLDERNDTTSSTTTLIYNETMTTNEPPSMLLVDTELMNSSEIMLLVAEPIPP Dmel_Ptp99A.AA TTGSGWE-----SLETEFNLATTVDSSTQKTEKEPVLGTVATSIEQQDQ---------PP Hsap_PTPRG.AA LQLDGFD---NESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSN-G Hsap_PTPRZ1.AA LKFQGWD---KTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMVFKASKITFHWGKCNMS :. * .:. : .: Spur_Spur_PTPRG.AA GEPKALKINSTSLVL---SWLPSDGPISNYSVSVRKGNYTSSWDLAVNQPPGASSEYTVY Dmel_Ptp99A.AA DVPATTLAFANAFPV------PVAGEMGN-----GNGNYNDATP---------------- Hsap_PTPRG.AA SAGSEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALD-- Hsap_PTPRZ1.AA SDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFK-- . . : : . :.. : Spur_Spur_PTPRG.AA GLMPYEFYQFHVRAHFSTGYFKDSPVSKLIRTAQGKPSQP--PGNVTVTTRGPFTIAVSW Dmel_Ptp99A.AA ---PY--------------------------AAVDDNYVPSKPQNLTILDVSANSITMSW Hsap_PTPRG.AA ---PIIHGLKGVVHHEKETFLDPFVLRDLLPASLGSYYRY--TGSLTTPPCSE---IVEW Hsap_PTPRZ1.AA ---AIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIY--NGSLTSPPCTD---TVDW . : .. .:* :.* Spur_Spur_PTPRG.AA ---KPPPPNSINGVLQNYKVMVSP----GSQVIKLGPSTLSTVIT----NRKP--FTLYI Dmel_Ptp99A.AA -----HPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRP--YTDYR Hsap_PTPRG.AA IVFRRPVPISYHQLEAFYSIFTTE----QQDHVKS----VEYLRN----NFRPQQRLHDR Hsap_PTPRZ1.AA IVFKDTVSISESQLAVFCEVLTMQ----QSGYVML----MDYLQN----NFREQQYKFSR . . :: : :. : * . Spur_Spur_PTPRG.AA VTIAVVNSANETGP----FSPTVNTSTDESVPGPPHGVIQVGKNPRSLQVFWNKPNLQNG Dmel_Ptp99A.AA VIVKAFTTKNEGEP-----SDQIAQRTDVGGPSAPAIVNLTCHSQESITIRWRRPYEFYN Hsap_PTPRG.AA VVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYH Hsap_PTPRZ1.AA QVFSSYTGKEEIHE--------------AVCSSEPENVQADPENYTSLLVTWERPRVVYD . .. * : . :: : * .* Spur_Spur_PTPRG.AA KIL--FYYAYIR------RRDSFFWSRFKTSKQHHLFLGLEVFTDYIIKVSASTNAGEGP Dmel_Ptp99A.AA TI--DFYIIKTRLAGQDTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINP Hsap_PTPRG.AA PPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKA--TISHVSPDSLYLFRVQAVCRNDMRS Hsap_PTPRZ1.AA TMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGA--ILNNLLPNMSYVLQIVAICTNGLYG : . : : : * ..: * Spur_Spur_PTPRG.AA N----------------------------------------------------------- Dmel_Ptp99A.AA K----------------------------------------------------------- Hsap_PTPRG.AA DFSQTMLFQ--------------------------------------------------- Hsap_PTPRZ1.AA KYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKE . Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA PQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISL Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA TSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFK Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA LDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIPESARNASEDSTSSG Spur_Spur_PTPRG.AA --------------------------------------------------STALFEKTDV Dmel_Ptp99A.AA ------------------------------------------------KIVLGKFSESRI Hsap_PTPRG.AA ------------------------------------------------ANTTRIFQGTRI Hsap_PTPRZ1.AA SEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPV *. : Spur_Spur_PTPRG.AA TAPS-------------------------------------------------------- Dmel_Ptp99A.AA IQ---------------------------------------------------------- Hsap_PTPRG.AA VKTG-------------------------------------------------------- Hsap_PTPRZ1.AA MSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETP Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA LQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAP Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA -----------------------VPTASPASSADMAPIS--------------------- Hsap_PTPRZ1.AA LLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSD Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA VLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQH Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ----------------------------------------------------SGSSTWTS Hsap_PTPRZ1.AA IFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSG Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA SGIPFSF----------------------------------------------------- Hsap_PTPRZ1.AA ASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPS Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ---------------------------------VSMATGMGPSSSGSQAT---------- Hsap_PTPRZ1.AA FNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQV Spur_Spur_PTPRG.AA -----------------------------------------------------EPHNITI Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA -----------------------------------------------------VASVVTS Hsap_PTPRZ1.AA PENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFST Spur_Spur_PTPRG.AA TVIGP------------------------------------------------------- Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA TLLAGLGFGGGGISSFPSTVWPT---------------------RLPTAASASKQA---- Hsap_PTPRZ1.AA EVLLQPSFQASDVDTLLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHS Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA TSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANL Spur_Spur_PTPRG.AA --------------GTARISWMEPF----------------------------------- Dmel_Ptp99A.AA --------------LQPNCEKLQPL----------------------------------- Hsap_PTPRG.AA --------------ARPVLATTEAL----------------------------------- Hsap_PTPRZ1.AA EINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASD . :.: Spur_Spur_PTPRG.AA ------------------------------------------------------------ Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA --------------------ASPGPDGDSSPTK--------------------------D Hsap_PTPRZ1.AA TFVSTDHSVPIGNGHVAITAVSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGED Spur_Spur_PTPRG.AA ------------------------------------------------------IFYNSI Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA GEGTEEGEKDEKSESEDG-----------EREHEEDGEKDSEKKEKS------GVTHAAE Hsap_PTPRZ1.AA GDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLS Spur_Spur_PTPRG.AA DSYTVSYRDINVSTPMLAAEITNTSRL-------LRNLQDDATYE--------------- Dmel_Ptp99A.AA ----------------------------------LRQSHND------------------- Hsap_PTPRG.AA ERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRRD----AGPGLDP---- Hsap_PTPRZ1.AA ENSEEDNRVTSVSSD--SQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPE : : . Spur_Spur_PTPRG.AA --------------------------VTVRAFTMST-----------------FLGRGLL Dmel_Ptp99A.AA ------------------------------------------------------------ Hsap_PTPRG.AA ----DMVTSTQVP-------------PTATEEQYAGSDPKRPE----------MPSKKPM Hsap_PTPRZ1.AA SKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQS Spur_Spur_PTPRG.AA QGEASLPQRFVMAYVPPTSGLLPGGTMKPG--EDAGRVVGVVFALFVLLGLILGVLGFVI Dmel_Ptp99A.AA ------------------------------------------YNLAVLVGIIFSCFGIIL Hsap_PTPRG.AA SRGDRFSEDSRFITVNPAEKNTSGMISRPA-----PGRMEWIIPLIVVSALTFVC--LIL Hsap_PTPRZ1.AA PTSSVTSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFIC--LVV * :: .: : ::: Spur_Spur_PTPRG.AA LRM----------------------------------RK---------KDRMSFEKHGNG Dmel_Ptp99A.AA IIMAFFLWS----------------------------RKCFHAAYYYLDD---PPHHPNA Hsap_PTPRG.AA LIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNE Hsap_PTPRZ1.AA LVGILIYW-----------------------------RKCFQTAHFYLEDSTSPRVISTP : ** .* . Spur_Spur_PTPRG.AA MAPTFCRPDDLEE---PAIHISKFESHVIACHANSDGGFAAEYE-------EIQH--VPT Dmel_Ptp99A.AA PQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYE-------AIQNECISD Hsap_PTPRG.AA SIPIIPIPDDME-----AIPVKQFVKHIGELYSNNQHGFSEDFE-------EVQRCTADM Hsap_PTPRZ1.AA PTPIFPISDDVG-----AIPIKHFPKHVADLHASS--GFTEEFETLKEFYQEVQSCTVDL . .: *: :. * .*: ::.. **: ::* :* Spur_Spur_PTPRG.AA SFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNS--DYINANYIDGFNRQKAYI Dmel_Ptp99A.AA DLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNL-DYINANFIDGYQKGHAFI Hsap_PTPRG.AA NITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYI Hsap_PTPRZ1.AA GITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYI .:.. *. :** **** ** :** *** * . . ******::**::. :*:* Spur_Spur_PTPRG.AA ATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLE Dmel_Ptp99A.AA GTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGV-ETYGVIQVKLI Hsap_PTPRG.AA ATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENS-EEYGNIIVTLK Hsap_PTPRZ1.AA AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGS-EEYGNFLVTQK .:**.* * : ***::**:. :*****:* *.****** *** .. * *. : *. Spur_Spur_PTPRG.AA LKEKFASYTLRTFLLKHRHKKHGKV-------PERRVYHFHYTDWPDHGVPPYTLPVLSF Dmel_Ptp99A.AA EEEVMSTYTVRTLQIKHLKLKKKKQ-----CNTEKLVYQYHYTNWPDHGTPDHPLPVLNF Hsap_PTPRG.AA STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF Hsap_PTPRZ1.AA SVQVLAYYTVRNFTLRNTKIKKGSQ---KGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTF : : **:* : :.: : *: . . * ::***:*** *.* :.****.* Spur_Spur_PTPRG.AA IQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNY Dmel_Ptp99A.AA VKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNF Hsap_PTPRG.AA VRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNY Hsap_PTPRZ1.AA VRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNY :..:: *. .**::***************:*:**:*:: : **::***..**:***: Spur_Spur_PTPRG.AA LVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVDRMTLPDEVGRVVLDEQFNLIMKMK Dmel_Ptp99A.AA LVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPY--------LEQQYKNIIQFQ Hsap_PTPRG.AA LVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCN Hsap_PTPRZ1.AA LVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSN ********:*:**.*:* : . :* : : : *::*:: : : : Spur_Spur_PTPRG.AA PRDYEFSKARQ--SKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYI Dmel_Ptp99A.AA PKDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFI Hsap_PTPRG.AA AKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFI Hsap_PTPRZ1.AA IQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFI . * : . *** :.* * :** :: .* .* *****:: *: . .::* Spur_Spur_PTPRG.AA VTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK--EDEPIYWPTNVDEPLTLGALTITLW Dmel_Ptp99A.AA VTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQF--WPDE-ATPIESDHYRVKFL Hsap_PTPRG.AA ITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSR-EESMNCEAFTVTLI Hsap_PTPRZ1.AA ITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNK-DEPINCESFKVTLM :**:* * :***.*:*:**: :* :.. :. : ** .: :.: Spur_Spur_PTPRG.AA KRNTLISPSSQGKFLGQSSQGTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHTAF Dmel_Ptp99A.AA NK------TNKSDYVSRD-------FVIQSIQ--DDYELTVKMLHCPSWPEMSNP-NSIY Hsap_PTPRG.AA SKDRL-CLSNEEQIIIHD-------FILEATQ--DDYVLEVRHFQCPKWPNPDAPISSTF Hsap_PTPRZ1.AA AEEHK-CLSNEEKLIIQD-------FILEATQ--DDYVLEVRHFQCPKWPNPDSPISKTF :.: . : .. :::: : ** * *. :*. **: * . : Spur_Spur_PTPRG.AA DLIYAVQKRNEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTV Dmel_Ptp99A.AA DFIVDVH------ERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYA Hsap_PTPRG.AA ELINVIK------EEALT-RDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVA Hsap_PTPRZ1.AA ELISVIK------EEAAN-RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVA ::* :: * . ** : * *. * :**:::* :: .:.:::: . Spur_Spur_PTPRG.AA KLYAAKRPNLITSREDYYYLFKALQSCHSAELQIRSLRRQGSRRGILDGPTAPNGREWNF Dmel_Ptp99A.AA KLYHNKRPGVWTSSEDIRVIYNILSFLPGN----LNLLKRTALRTEFEDVTTATPDLYSK Hsap_PTPRG.AA KMINLMRPGVFTDIEQYQFIYKAMLSLVST------------------------------ Hsap_PTPRZ1.AA KMINLMRPGVFADIEQYQFLYKVILSLVST------------------------------ *: **.: :. *: ::: : . Spur_Spur_PTPRG.AA LRSPGHVDPGSMRLSDSVRNSSLDSDGFYRTRSQTMSSAGPQRHPRPSKFWHRRTKSEK- Dmel_Ptp99A.AA ICSNGNVPQHVILQQQQLHMLQLQQQHLETQQQQQQQQQQQQQQQQQTALNETVSTPSTD Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA ------------------------------------------------------------ Spur_Spur_PTPRG.AA -------RKPLNPPNAATTRRSSIATTPGDRTPSESLGEVYELINVRSKDST-----PNS Dmel_Ptp99A.AA TNPSLLPILSLLPPTVAPLSSSSSTTPPPPSTPTPQPPQTIQLSSHSPSDLSHQISSTVA Hsap_PTPRG.AA -------KENGNGPM--TVDKNGAVLIADESDPAESMESLV------------------- Hsap_PTPRZ1.AA -------RQEENPST--SLDSNGAAL--PDGNIAESLESLV------------------- . . .. . : . . Spur_Spur_PTPRG.AA PTGNEEFVLIGETGVTSEYPVVSPEIHESSGDISNGNIEEMGEETSGRKPKEAAYRPVSQ Dmel_Ptp99A.AA NAGSPATASAGATPTTPMTPTVPPTIPTIPSLASQNSL---------------------T Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA ------------------------------------------------------------ Spur_Spur_PTPRG.AA LCDDDRECMDVDGEDDDGDDDIPANECTLNEDLDNLNMNGEMVNLNVNGAIDLYDEPQDV Dmel_Ptp99A.AA LTNANFHTVTNNAAD--------LMEHQQQQMLALMQQQTQLQQQYNTHPQQHHNNVGDL Hsap_PTPRG.AA ------------------------------------------------------------ Hsap_PTPRZ1.AA ------------------------------------------------------------ Spur_Spur_PTPRG.AA DMDTNISELNGEVTPLDLPAEVIGKLSHERKSYYSQESVNSAQETEPLNAESS Dmel_Ptp99A.AA LMNNADNSPTASPT--------ITNNNHITNNNVTSAAATDAQNLDIVG---- Hsap_PTPRG.AA ----------------------------------------------------- Hsap_PTPRZ1.AA -----------------------------------------------------