CLUSTAL W (1.81) multiple sequence alignment Cele_ida-1.AA ------------------------------------------------------------ Hsap_PTPRN.AA ------------------------------------------------------------ Hsap_PTPRN2.AA ------------------------------------------------------------ Dmel_ia2.AA MPAVGTSCGVPIIMARNVQQRQQHPCTTTEEPKHQRARGTAGHQESATGECQQFWSKQRP Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA ------------------------------------------------------------ Hsap_PTPRN.AA ------------------------------------------------------------ Hsap_PTPRN2.AA ------------------------------------------------------------ Dmel_ia2.AA PFDQQQQQEDQDPEQDPQQHPSTPQESVHHHRSPRQHELLHHQRKVPPTLPARGRHLISE Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA --------------MRFFH----------------SIIVLLFSIST------------GS Hsap_PTPRN.AA --MRRPRRPGGLGGSGGLR----------------LLLCLLLLSSR---------PGGCS Hsap_PTPRN2.AA ------------MGPPLPL----------------LLLLLLLLPPRVLPAAPSSVPRGRQ Dmel_ia2.AA GARRREVRGCGAGGGGLLCCSLDALSRPAKLLQFGVLLLILLLATH---------GDLAQ Nvec_Nvec_PTPRN.AA -------------------------------------------------------MKDNS Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA AFLLYGCNLSENLC-DNDESCYPDGVFGQCYSSESGSPEPTVLDNLDDTQLELLKLELTR Hsap_PTPRN.AA AVSAHGCLFDRRLC-SHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVLQRLQG---VLRQ Hsap_PTPRN2.AA LPGRLGCLLEEGLC-GASEACVNDGVFGRCQKVPAMDFYRYEVSPVALQRLRV---ALQK Dmel_ia2.AA AEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEE Nvec_Nvec_PTPRN.AA YTQESGKQVAKRLN------------------------EDGSVKDEVSKRMNV------- Spur_Spur_PTPRN1.AA ---------------------------------------MLVRQRPADERQRLADESITE Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA LAAKDKDWGDEETQCVLAYFKMSMFYQLQYDPDFCQVRKP-------------------- Hsap_PTPRN.AA LMSQGLSWHDDLTQY------VISQEMERIPR--LRPPEPRPRDRSGLAP-------KRP Hsap_PTPRN2.AA LSGTGFTWQDDYTQY------VMDQELADLPKTYLRRPEASSPARPSKHSVGSERRYSRE Dmel_ia2.AA LQGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPP Nvec_Nvec_PTPRN.AA ---------------------RIISADGEVPEKHDSQAEPKKVT---------------- Spur_Spur_PTPRN1.AA EDADEIV--------------ALLVSLLELPPSIFSDIKVKDKE---------------- Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA ------------------------------------------------------------ Hsap_PTPRN.AA GPAGELLLQDIPTGSA---PAAQHRLPQPPVGK--------------------------- Hsap_PTPRN2.AA GGAA-------LANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTY Dmel_ia2.AA EPEAELDYYEQPAGPAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKM Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA ---------------------------------------ANVWALIQLIDTGLTEDPTIL Hsap_PTPRN.AA -GGAGASSSLSPLQAELLPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVS Hsap_PTPRN2.AA VAHTSALTYPPGSRTQLREDLLPRTLGQLQPDELSPKVDSGVDRHHLMAALSAYAAQRPP Dmel_ia2.AA DGHGQSTQLDAPS---IMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAAS Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA -----------------------------------ITVHVNDSSRHFTPKAIAIKIVDGS Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA DEDVNPENVTDEDMAQIIEQLKEPSLPTEEDIEEALNAQNEDVDDEILDQY--------- Hsap_PTPRN.AA EGSPGMVSVGP------LPKAEAPALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSG Hsap_PTPRN2.AA AP-PGEGSLEPQYLLRAPSRMPRPLLAPAA------PQKWPSPLGDSEDPS-----STGD Dmel_ia2.AA EPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEV-----NESS Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA VVVVQQWSHSREVLGSKPSRCPRALLFLSHEALRIFGDSGYGQHNDHP------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA ------------------------------------------------------------ Hsap_PTPRN.AA LLYLAQELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKPASP---------- Hsap_PTPRN2.AA GARIHTLLKDLQRQPAEVRGLSGLELDGMAELMAGLMQGVDHGVARGSPGRAALGESGEQ Dmel_ia2.AA ELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEV Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA ----------------------------VQAVVNNENPDFSELSDGQLNILIGRLVDLKK Hsap_PTPRN.AA AVQPDAALQR------------------LAAVLAGYGVELRQLTPEQLSTLLTLLQLLPK Hsap_PTPRN2.AA ADGPKATLRG------------------DSFPDDGVQDDDDRLYQEVHRLSATLGGLLQD Dmel_ia2.AA DATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKS Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA NVENEEAQLL-------------------------------------------------- Hsap_PTPRN.AA GAGRNPGGVVNVGADIKKTMEGPVEGRDTAELP----------------ARTSPMPGHPT Hsap_PTPRN2.AA HGSRLLPGALPFARPLDMERKKSEHPESSLSSE----------------EETA---GVEN Dmel_ia2.AA QRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLLGPPS Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA ---TGDGEQEMAVPLDDLEERGEQAILKKDIEQVGEINQGLDNTEHKIVKGRKDQVVTRV Hsap_PTPRN.AA ASPTSSEVQQVPSPVSSEPPKAARPPVTPVL-------LEKKSPLGQSQPTVAGQPSARP Hsap_PTPRN2.AA VKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQEALSDGLQLEVQPS Dmel_ia2.AA LGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTV Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA DAN---RVYLKVHLKNEDQLMPLIEFLQNTIAIPNNLYFDDFQFENGQLSMRISRFEGAK Hsap_PTPRN.AA AAEEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSG-SFINISVVGPALTFRIRHNEQNL Hsap_PTPRN2.AA EEEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSS-AFADVEVLGPAVTFKVSANVQNV Dmel_ia2.AA DTE-YVHVFVKNPIDSWNDGQRIMKELEQILHMQG--YFSYLTVQQHEVSFRVNSNNPER Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA PKADKRIDSVEGVASAVYKRRKDIARLSGADVRETGIG-SGEDGSLPVESSER-----DW Hsap_PTPRN.AA SLADVTQQA----GLV----KSELEAQTGLQILQTGVGQREEAAAVLPQTAHS-----TS Hsap_PTPRN2.AA TTEDVEKATVDN--------KDKLEETSGLKILQTGVGSKSKLKFLPP-QAEQ-----ED Dmel_ia2.AA KTAGDVARTINENRGV----KNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQG Nvec_Nvec_PTPRN.AA ----------------------------------------------------------NV Spur_Spur_PTPRN1.AA -----------------------------VKVVSAGG---------------------SD Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA LLMPVLFVCAFTVTALGLVAAVQIARS--RRHYKDNIQQIAEQLDG-----KNSFAYQDL Hsap_PTPRN.AA PMRSVLLTLVALAGVAGLLVALAVALCV-RQHARQQDKERLAALGPEGAHGDTTFEYQDL Hsap_PTPRN2.AA STKFIALTLVSLACILGVLLASGLIYCL-RHSSQHRLKEKLSGLGGDPGA-DATAAYQEL Dmel_ia2.AA PDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAE-TCSKDYQEL Nvec_Nvec_PTPRN.AA QPKYFLVTVTVVGCVTGVILAAVAIYLIMKRYNETKKFKPVTLPGQ-----EAAADYQEL Spur_Spur_PTPRN1.AA NAALVILTVVLVACVVGILIAIVTVYCLKKRSNEKAKVTELKQSEGENGN-EASADYQDL Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA CRQR------------------------------------ADGGRASKSSSTSSWCEETA Hsap_PTPRN.AA CRQHMATKSLFNRAE-------GPPEPSRVSSVSSQ-FSDAAQASPSSHSSTPSWCEEPA Hsap_PTPRN2.AA CRQRMATRPPD--RP-------EGPHTSRISSVSSQ-FSDGPIPSPSARSSASSWSEEPV Dmel_ia2.AA CRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSL-SKENEGRPPSSRSSTSSWSEEPA Nvec_Nvec_PTPRN.AA CRQLRAN---------------QGWDSAPVKSGSGH-MEKEKGLLGSAKPPKYTWSEEPV Spur_Spur_PTPRN1.AA CRQRMAT---------------KSDKPEPLTRVSSVAASEGAQPSPSSRSSTSSWSEEPV Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA VPTIDISTGHVVLNFLQEYLSEPTKIEAQWNGIKDYRNEERTK--TKAEKFASQNR--TI Hsap_PTPRN.AA QANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDF Hsap_PTPRN2.AA QSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAV Dmel_ia2.AA LTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAP Nvec_Nvec_PTPRN.AA VPNMDISTGHVVLSYMEDHLSNKNRLNKEWEALCNYEAEPSVADLGKQDKNVRKNRYSDV Spur_Spur_PTPRN1.AA QSNMDISTGHVVLSYMEDHLNNKDRMSKEWEALCSYEADPCTQDAGKAPENANKNRVKNA Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA LPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGV Hsap_PTPRN.AA LPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGC Hsap_PTPRN2.AA LTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGC Dmel_ia2.AA LPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGA Nvec_Nvec_PTPRN.AA LPYDHNRVSLRETANATGSDYINASFITDHDPRNPAYIATQGPLAHTVSDFWQMVWEQGV Spur_Spur_PTPRN1.AA IPYDHTRVKLTEETSANKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGS Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA CLVVNLS--TPEECKQEKNYWPDTGSEVHGAFEIHLVSEHIWSDDYLVRSFYLKNLQNSQ Hsap_PTPRN.AA TVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQE Hsap_PTPRN2.AA VVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNE Dmel_ia2.AA VVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSE Nvec_Nvec_PTPRN.AA VVIVNLTRLSDLGLPQCHRYWPEDGHETYHIYEVHLVSEHIWCDDYLVRSFYLKNLQTSE Spur_Spur_PTPRN1.AA VVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHVWCEDYLVRSFYLKNLETQE Spur_Spur_PTPRN2.AA ---------------------------------------------------------TQE ..: Cele_ida-1.AA TRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRG-RSSAVLVHSWDGSGRTGVYCAV Hsap_PTPRN.AA TRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG-RSCPIIVHCSDGAGRTGTYILI Hsap_PTPRN2.AA TRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRG-RSCPIIVHCSDGAGRSGTYVLI Dmel_ia2.AA TRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILL Nvec_Nvec_PTPRN.AA TRTVTQFHFLSWPDLNVPTTPKPLLEFRRKVNKCFRG-RSCPIVVHCSGGVGRTGCYILI Spur_Spur_PTPRN1.AA TRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRG-RACPIVVHCSDGVGRTGTYCLL Spur_Spur_PTPRN2.AA TRTVTQFHFLTWPETGCPPSPKSLLEFR-------------------------------- ***:****:*:* . *. ...:*:** Cele_ida-1.AA DVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLLKSIATK-- Hsap_PTPRN.AA DMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALPQ--- Hsap_PTPRN2.AA DMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ--- Dmel_ia2.AA DLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTS Nvec_Nvec_PTPRN.AA DLVLNKMMRGAKEIDIAATVEHLRDQRPHMVKTKAQFEFALTAVAEEVNAILQALAK--- Spur_Spur_PTPRN1.AA DLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAILKALPQ--- Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA ------------------------------------------------------------ Hsap_PTPRN.AA ------------------------------------------------------------ Hsap_PTPRN2.AA ------------------------------------------------------------ Dmel_ia2.AA GEKRELDKDPVVGGGSSSTTTKEPLKEDKAQEAAEEEAPTSSSKAAAAAKKEKEKDKDKE Nvec_Nvec_PTPRN.AA ------------------------------------------------------------ Spur_Spur_PTPRN1.AA ------------------------------------------------------------ Spur_Spur_PTPRN2.AA ------------------------------------------------------------ Cele_ida-1.AA ------------------------- Hsap_PTPRN.AA ------------------------- Hsap_PTPRN2.AA ------------------------- Dmel_ia2.AA EKQAKDQAKVAEPRTPAKSAKQAKK Nvec_Nvec_PTPRN.AA ------------------------- Spur_Spur_PTPRN1.AA ------------------------- Spur_Spur_PTPRN2.AA -------------------------