CLUSTAL W (1.81) multiple sequence alignment Aque_aque_SSH.AA ------------------------------------------------------------ Mbre_mbre_SSH-A.AA -----------------------MMASSQHDPDRPDALLIAEDCLSPSAEGHEHYHLYSV Mbre_mbre_SSH-B.AA --------------------MATSQSPRGSSLSGLNRRTTISSPHAGLKQRTASRMFSVM Spur_spur_SSH.AA MGCCKGKCKLSTRYIPVTIAYILVIGTSGLFFAFPLRDLIVKCEYHPSIAAFDGLLFLVA Nvec_nvec_SSH.AA ------------------------------------------------------------ Dmel_ssh.AA ------------------------------------------------------------ Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA ------------------------------------------------------------ Hsap_SSH2.AA ------------------------------------------------------------ Aque_aque_SSH.AA ------------------------------------------------MSLQTLERSSPS Mbre_mbre_SSH-A.AA ---------------------------ERREVRQLACRVNFVDSRDTPPRYCLLTRPDEC Mbre_mbre_SSH-B.AA ---------------------------RHGPRRTLSIATASAHAAAKELPMYVLQRHREG Spur_spur_SSH.AA LINFLLATFVDPGVFPRTAVGDEDRDDDLRAPLYKTVQIRGIQVRMKWCSTCRFYRPPRC Nvec_nvec_SSH.AA -------------------------------------------MVFREADSVLLYRASSP Dmel_ssh.AA ------------------------------------------------MALVTVQRSPSV Hsap_SSH3.AA ------------------------------------------------MALVTVSRSPPG Hsap_SSH1.AA ------------------------------------------------MALVTLQRSPTP Hsap_SSH2.AA ------------------------------------------------MALVTVQRSPTP . * Aque_aque_SSH.AA PQESISES---------------------------------------------------- Mbre_mbre_SSH-A.AA AAAYLATSAPLSPTLSTPL----------------------------------------- Mbre_mbre_SSH-B.AA GGGLFTYNTTRTTAVAGDL----------------------------------------- Spur_spur_SSH.AA SHCSVCNNCIERFDHHCPWVNNCVGRRNYRYFFLFLLSLTMHMVSVFVLSLIYVLQAKAS Nvec_nvec_SSH.AA -----------------HW----------------------------------------- Dmel_ssh.AA AG---SCS-----NSDGES----------------------------------------- Hsap_SSH3.AA SGASTPVG---------PW----------------------------------------- Hsap_SSH1.AA SAASSSAS-----NSELEA----------------------------------------- Hsap_SSH2.AA STTSSPCA------SEADS----------------------------------------- Aque_aque_SSH.AA ---------------------------------------EDQGSLSSYEGFVCREGCAIC Mbre_mbre_SSH-A.AA ---------------------PQIGLGIAPLHLSHLFDSGDVHLWVCRATYRTTSTAAIA Mbre_mbre_SSH-B.AA ------------------------------PFARLDSITAARDPRQGRGGGISAAEAASA Spur_spur_SSH.AA ISDYQKIISSVTNTYTWPVYGPLLAFGICLCLVHDNDDEAEERLKRGCESFFAMKGAAIV Nvec_nvec_SSH.AA ----------------------------------------KRIRRSSFEGFFASKGAAFS Dmel_ssh.AA -----------------------------------EDDEGNSKGNDRSECFFAGKGTALV Hsap_SSH3.AA -----------------------------------DQAVQRRSRLQRRQSFAVLRGAVLG Hsap_SSH1.AA -----------------------------------GSEEDRKLNLSLSESFFMVKGAALF Hsap_SSH2.AA -----------------------------------GEEECRSQPRSISESFLTVKGAALF . Aque_aque_SSH.AA LTPRP-------------------GASVGKHKGSL----------RIMNHLRKLNKLMRP Mbre_mbre_SSH-A.AA IDEDDDGDSTSGVVDETRASSRAESITTDEDS-------------RMHPVLDHLDGLLNV Mbre_mbre_SSH-B.AA LRRQRQLKKQSASPTSSPASTAPTNAPSNEDSGMA----------EVEQVLELAASLLNE Spur_spur_SSH.AA LPHSKDT-----------------KRPIKKHPVVG----------ELQQHLQCIFWILRP Nvec_nvec_SSH.AA IPDG--------------------DFARKASKHGG----------EMQVHLQSMVNLLRD Dmel_ssh.AA LALKDIPPLTQSERRLSTDST---RSSNSTQSNNS----------DIQLHLQSMFYLLQR Hsap_SSH3.AA LQDGGDNDDAAEASSEPTEKAPSEEELHGDQTDFGQGSQSPQKQEEQRQHLHLMVQLLRP Hsap_SSH1.AA LQQGSSPQGQ--------------RSLQHPHKHAG----------DLPQHLQVMINLLRC Hsap_SSH2.AA LPRGNGSSTP--------------RISHRRNKHAG----------DLQQHLQAMFILLRP : * ::. Aque_aque_SSH.AA QDAIRLGVELERCT-------VRPVTRYMVVISTQ------------------------- Mbre_mbre_SSH-A.AA GDSCMYVFSNADNSTLNESATELPRNSYLALIRHD------------------------- Mbre_mbre_SSH-B.AA EDDCVLACKLHQLD--SDMETASDKRFFLALIRHS------------------------- Spur_spur_SSH.AA EDTIKMAVRLESSS--------DNTIRYMVLVSCL------------------------- Nvec_nvec_SSH.AA NDVLRLVVKLETKY------YLPGKVRYLAVVSSF------------------------- Dmel_ssh.AA EDTLKMAVKLESQR--------SNRTRYLVIASRSCCRSGTSDRRRHRIMRHHSVKVGGS Hsap_SSH3.AA QDDIRLAAQLEAPR--------PPRLRYLLVVSTR------------------------- Hsap_SSH1.AA EDRIKLAVRLESAW--------ADRVRYMVVVYSS------------------------- Hsap_SSH2.AA EDNIRLAVRLESTY--------QNRTRYMVVVSTN------------------------- * :: : Aque_aque_SSH.AA --------------------------------------------GVQ--DTEETIVLGT- Mbre_mbre_SSH-A.AA -------------------------------------------------ETDQWALLGM- Mbre_mbre_SSH-B.AA --------------------------------------------------ENQACILCLS Spur_spur_SSH.AA -------------------------------------------DTHQ--NTEETIILGM- Nvec_nvec_SSH.AA --------------------------------------------SLD--DIEESVVLGI- Dmel_ssh.AA AGTKSSTSPAVPTQRQLSVEQTATEASSKCDKTADKENATAAGDNKNTSGMEESCLLGI- Hsap_SSH3.AA --------------------------------------------EGEGLSQDETVLLGV- Hsap_SSH1.AA --------------------------------------------GRQ--DTEENILLGV- Hsap_SSH2.AA --------------------------------------------GRQ--DTEESIVLGM- :: :* Aque_aque_SSH.AA -------E---QSA-DVIKICLVLPLWRNTEIKLDGDGGFSVHC----QDKHHMLKPLSV Mbre_mbre_SSH-A.AA -------ELATPGSGDILQVDVVFAVDHTCDIVLDGDGGLVYQSQQGKEQRFMPFRPASI Mbre_mbre_SSH-B.AA RQAETPAEPIKDGD-HAFHVDHVVPIGRQSNFKLHGDGTFTFNN---------ILDP--- Spur_spur_SSH.AA -------DIIQNKA----TIGLVLPIWADSIIQMDGDGGFSVTT----GEKINVFKPVSI Nvec_nvec_SSH.AA -------DWVDESA----TIGLVLPLWRDTAIELDGDGGFELST----NSTVHFLKPVSV Dmel_ssh.AA -------DCNERT-----TIGLVVPILADTTIHLDGDGGFSVKV----YEKTHIFKPVSV Hsap_SSH3.AA -------DFPDSSS-PSCTLGLVLPLWSDTQVYLDGDGGFSVTS----GGQSRIFKPISI Hsap_SSH1.AA -------DFSSKES-KSCTIGMVLRLWSDTKIHLDGDGGFSVST----AGRMHIFKPVSV Hsap_SSH2.AA -------DFSSNDS-STCTMGLVLPLWSDTLIHLDGDGGFSVST----DNRVHIFKPVSV : : *. : . : *** : : * Aque_aque_SSH.AA QSMWTALQFLFKATEQARSYNYYDGGLSHTWMTFYQAQLTDDGIALNEWRLQ-----GSL Mbre_mbre_SSH-A.AA RNLWDALQAILKIREGSGRDH-----SDWIWLEFYRNKINDTQQQLQRWTHIVPSRTSEL Mbre_mbre_SSH-B.AA ----------HQTNEDDNSE---------------------------------------- Spur_spur_SSH.AA QAMWSALQALYRACNLARVHNYFIGGLHMTWIGFYQSSVSSPYYCLKEWEYL-----PDM Nvec_nvec_SSH.AA QTMWTAFQWIHKCSDNARRNNQYPAGTSHSWVKYYENQISSDQTCIKEWYVT-----F-- Dmel_ssh.AA QAMWSALQTLHKVSKKARENNFYASGPSHDWLSSYERRIESDQSCLNEWNAM-----DAL Hsap_SSH3.AA QTMWATLQVLHQACEAALGSGLVPGGSALTWASHYQERLNSEQSCLNEWTAM-----ADL Hsap_SSH1.AA QAMWSALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAM-----QDL Hsap_SSH2.AA QAMWSALQSLHKACEVARAHNYYPGSLFLTWVSYYESHINSDQSSVNEWNAM-----QDV . . Aque_aque_SSH.AA LSFRPDSPIYYDVKGLADWTQLDAEKRAFKDTLIQKLRDVMLHLDLDTASSRQIRQQLEN Mbre_mbre_SSH-A.AA QLIRKQQAGALQRDKG------PHLDSELEQRIISKLKEIMFKSDLDTITSKQLRLQLEA Mbre_mbre_SSH-B.AA ----PSTPRPFE----------ERSEDEWRRLLLPEIKKIIAASDLDTLTSKEVRLALEL Spur_spur_SSH.AA TSPQSDEINYLYHRDRRYC---PTEDELIRRFIFVKLKEIMIQCDLETVTSKMVRISLEK Nvec_nvec_SSH.AA ----PN----------------SKEDELLRKLLRHKLREVMMTVDLEEVTSRQVRELVEA Dmel_ssh.AA ESRRPPSPDAIRNK--------PPEKEETESVIKMKLKAIMMSVDLDEVTSKYIRGRLEE Hsap_SSH3.AA ESLRPPSAEPGG----------SSEQEQMEQAIRAELWKVLDVSDLESVTSKEIRQALEL Hsap_SSH1.AA ESTRPDSPALFVDK--------PTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEK Hsap_SSH2.AA QSHRPDSPALFTDI--------PTERERTERLIKTKLREIMMQKDLENITSKEIRTELEM : ::. :: **: :*. :* :* Aque_aque_SSH.AA EMMMNLKEYRGFLDQQMLYIVGQLEEPSKIHEYLYLGTEWNASNLLELKEMGVEYILNMT Mbre_mbre_SSH-A.AA EFDMDLKKYRKIIDQQMITVMGQMEPSSKIFDYLYLGTEWNASNWEELSRNNCQYIINVT Mbre_mbre_SSH-B.AA KFGRTLKQFKGYIDEQMIVAFGQMAPPSPISDLIFLGTEWNACNLEELRENGCSHILNVT Spur_spur_SSH.AA EIGKELKEYKRFIDKQILLICGQLDSASKIFDHIYLGSEWNASDLDELEENGVGYILNIT Nvec_nvec_SSH.AA EVQMDLKQYKQYIDKEMLTIFGQMDSASKIYDHVYLGSEWNASNLEELKENGVEYVLNIT Dmel_ssh.AA ILDMDLGEYKSFIDAEMLVILGQMDAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVT Hsap_SSH3.AA RLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSEWNAANLEELQRNRVTHILNMA Hsap_SSH1.AA QMNCNLKELKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVT Hsap_SSH2.AA QMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVT . * : . :* ::: .* .: * ::**:****.: :* :::*:: Aque_aque_SSH.AA KEIDNFYPESFKYKTIRVYDLPESELLKHWDDTYKFIKEVKERKSKLLVHCKMGISRSAA Mbre_mbre_SSH-A.AA CEIENFFPDKIKYCNIRVWDVPTTTIWPNWNRTYDFIRQARKAGSSVLVHCKMGVSRSAS Mbre_mbre_SSH-B.AA EEVPSYFEQDFEYLRISLPDEETENLLQHWNRTFDFIELARANDSRVLVHCKMGVSRSAS Spur_spur_SSH.AA KECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSAS Nvec_nvec_SSH.AA KEIDNFFAGTFTYFNIRLWDLEDSNLLPYWDETFKFINQARDKGSKVLVHCKRGISRSAS Dmel_ssh.AA REIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSAS Hsap_SSH3.AA REIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAA Hsap_SSH1.AA REIDNFFPGLFAYHNIRVYDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSAS Hsap_SSH2.AA REIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSAS * .:: : * : : * : *. :. :: .. : ***** *:****: Aque_aque_SSH.AA TVIAYTMKEYRMSLEDALSFVRSQRSCIKPNHGFMSQLKAYEGIL---KARYNDLF---- Mbre_mbre_SSH-A.AA TVIAYAMKQYSWSLEEAHAFVKKRRRIIKPNEGFRTQLVMYEGMLTARRSG--------A Mbre_mbre_SSH-B.AA TVMAYLMRFHGWTRDHTFEYVRERRNVVQPNKGFWEQLK--------------------- Spur_spur_SSH.AA TVIAYAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILEASRQRH-TMF---R Nvec_nvec_SSH.AA TVIAYGMKEYGTSLNDTMKHVKSRRQCVNPNQGFWKQLITYEGILNSSRHRYNELFNNNK Dmel_ssh.AA VVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAMKNKE-KLQ---R Hsap_SSH3.AA TVLAYAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQGILTASRQSH--VW---E Hsap_SSH1.AA TVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLW---R Hsap_SSH2.AA TVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQRHNKLW---R .*:** *. . : : .*. * .** * ** Aque_aque_SSH.AA --------------------------GTQAPSRITFQSRSSSDPNIRQRLFVNEEELE-- Mbre_mbre_SSH-A.AA FGTELDIKPPPHAPIPLSQPVTPTIKKVTPPDSPVSTPPSTPAPELRAWTLGNRVAAERG Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA SKSESS-LSRSESVECLAS---------VKPPEFGSTEDLSPRGMPRNKSFSVRERKKKI Nvec_nvec_SSH.AA QRSNSEIIRETKRKRRRHGRHKHSTITTTRTPEVDMVINKTKRNSIERDTFGDIITEDSV Dmel_ssh.AA SKSETN-LKSTKDARLLPG--------------------SEPTPLIQ--ALNQAKSKSTG Hsap_SSH3.AA QKVGGV-----------------------SPEEHPAPEVSTPFPPLP------------- Hsap_SSH1.AA QQTDSS-LQQPVDDPAGPG------------DFLPETPDGTPESQLP--FLD-----DAA Hsap_SSH2.AA SHSDSD-LSDHHEPICKPGLELNKKDITTSADQIAEVKTMESHPPIPPVFVEHMVPQDAN Aque_aque_SSH.AA ------------------------------------------------------------ Mbre_mbre_SSH-A.AA SQVA-------------------------------------------------------- Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA EELD-------------------------------------------------------- Nvec_nvec_SSH.AA GEGE------------SDDGGSAGFEDDDEEEEEDGSIMMRRFLRDTSSGDDVFYSWE-- Dmel_ssh.AA EAGV-------------------------------------------------------- Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA QPGL-------------------------------GPPLPCCFRRLSDPL---------- Hsap_SSH2.AA QKGLCTKERMICLEFTSREFHAGQIEDELNLNDINGCSSGCCLNESKFPLDNCHASKALI Aque_aque_SSH.AA ----IQLADGERGQETPQDAHEHNEVEDEPPQMRPVSAGTHPPLNSTKTSPL-------- Mbre_mbre_SSH-A.AA ----LEDAGTTERERAGSETSPKQAAAADPG----------------------------- Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA ----SPEGAVGGPSFFIGPDPTHLGAGKYVM-------DTGEPLCEGAVGNDP------- Nvec_nvec_SSH.AA ----TEDIDSTTPVRSSTPDPDHIGIKEDQSIV--NKGEKRRPIHRTNSSPMLRKKVKRK Dmel_ssh.AA ----TPDGEEEDGSRMHRRSIAQKSQRRMVRRSSSTSPKTQTAVVTKQQSQSMENLTPER Hsap_SSH3.AA -----PEPEGGGEEKVVGMEESQAAPKEEPG----------------------------- Hsap_SSH1.AA ----LPSPEDETGSLVHLEDPEREALLEEAA----PPAEVHRPARQPQQGSGL------- Hsap_SSH2.AA QPGHVPEMANKFPDLT-VEDLETDALKADMNVHLLPMEELTSPLKDPPMSPDPESPSPQP Aque_aque_SSH.AA ------------------------------------------------------------ Mbre_mbre_SSH-A.AA ------------------------------------------------------------ Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA ---------GVSDCNDFQVL---------------VPPTVRPSSIVKLQKEGALALGDVP Nvec_nvec_SSH.AA SHKKTLDNSELDRCQSLREMLTGRVAALREDLQGNKGRSTGVKIAKTLSTESAEETCKAG Dmel_ssh.AA SVAEEP-----KNMRFPGSN--GENYSVTQNQVLHIQKHTPLSVRTRIHDLEAHRADQ-- Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA -CEKDVK----KKLEFGSPK--GRSGSLLQ------VEET-----EREEGLGAGRWGQ-- Hsap_SSH2.AA SCQTEISDFSTDRIDFFSAL--EKFVELSQ------ETRSRSFSHSRMEELGGGRNESCR Aque_aque_SSH.AA ----QIPLVLESRVHQSLPPEKAEGMMNYLESLDTHHIEDERDLGINDPSSSE------- Mbre_mbre_SSH-A.AA ----EMPVTEVSEDI--------------------------------------------- Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA FVVATEPAALSSTVL-----SSSKELVSSEADTVEGSSMEDTMLNTNNNSANELSLDGSD Nvec_nvec_SSH.AA ETIEEPVPEREIQLVPLLNEKNELFINDGDEEIFDTGLMEGETPDVGSSEDLHQNVDAHG Dmel_ssh.AA -LPQQPVWTSLTKLI-----TQTSHLGKSVSGSSSGNIDSR-----RDSSCSDVFSSQVD Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA ------LPTQLDQNL-----LNSENLNNNSKRSCPNGMEDD------------------- Hsap_SSH2.AA LSVVEVAPSKVTADD-----QRSSSLSNTPHASEESSMDEEQSKAISELVSPDIFMQSHS Aque_aque_SSH.AA ------------------------------------------------------------ Mbre_mbre_SSH-A.AA ---------AFRIKKYSQAVGV-------------------------------------- Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA EDMYQRTSVKSKVTEIESSV--------------------MGAMDATEEEGEGEGE---- Nvec_nvec_SSH.AA LSAVKTGTVKRQSRNFEEGKVNLPWEWEKMGPDPASEPKEVITFLLKETTGVQGAPVPEV Dmel_ssh.AA SVFAKDEGEKRQRRKTHSWTESLGPSGGIV-LDPTPQQQKQQSNAILRPRGTRQRELPSR Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA ----AIFGILNKVKPSYKSCAD------------CMYPTASGAPEASRERC----EDP-- Hsap_SSH2.AA ENAISVKEIVTEIESISQGVGQIQLKGDIL-PNPCHTPKKNSIHELLLERA----QTPEN Aque_aque_SSH.AA -------------------------------------SESPFSSPPFTPPDEDGMTFQRY Mbre_mbre_SSH-A.AA -------------------------------------TATPLHSGSSGDAVAGGVSRNRP Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA -------------------------------------SEVGAYKRESIPWNPGTVLRQK- Nvec_nvec_SSH.AA DPGVVRKHASALEKKYLGVQERESKLSGSDSEIDHGSTESPVSIPPKKLIIPETSFAIES Dmel_ssh.AA HASWGSGDNRCC-------------------------LPQRTSSGSYYDSNRNTTAIFE- Hsap_SSH3.AA ---------------------------------------------------------PRP Hsap_SSH1.AA -------NAPAI-------------------------CTQPAFLPHI-TSSPVAHLASR- Hsap_SSH2.AA KPGHMEQDEDSC-------------------------TAQPELAKDSGMCNPEGCLTTH- Aque_aque_SSH.AA TSTIKSMRKT-------------------------------------------------- Mbre_mbre_SSH-A.AA HSLHFDRDGN-------------------------------------------------- Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA -QEIEEKMRD-------------------------------------------------- Nvec_nvec_SSH.AA VGKTPQVEQGFVGILDTSAVRRKINEDMHKEKQQRRRLSGEQKIQNMTSTAAGNVKAVEV Dmel_ssh.AA -GVIQDLKRS-------------------------------------------------- Hsap_SSH3.AA RINLRGVMRS-------------------------------------------------- Hsap_SSH1.AA -SRVPEKPAS-------------------------------------------------- Hsap_SSH2.AA -SSIADLEEG-------------------------------------------------- Aque_aque_SSH.AA ----ETSHNSSDVLAASTLSPNDSVHSRVARATSLP------------------SSLRPS Mbre_mbre_SSH-A.AA ---------------PTGRARVSTNPDPKVSGADYK-----------------HRTWSDR Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA -----GSPTSSVSMKFDGEGE-----EGDEEGRSET---------------QVVSIVDEL Nvec_nvec_SSH.AA MEPDLGKSKAAVTLKDSDEEPIKGIVRKHAKGFEER-----------HRGLEVGSNLDQD Dmel_ssh.AA -----SNCNVIEGVAV-AVEPIVGVGEGTVKRTKQK--------------LEESTSLKKR Hsap_SSH3.AA -----------------------------------------------------ISLLEPS Hsap_SSH1.AA -----GPTEPPPFLPPAGSRRADTSGPGA--GAALE---------------PPASLLEPS Hsap_SSH2.AA -----EPAEGEQELQGSGMHPGAKWYPGSVRRATLEFEERLRQEQEHHGAAPTCTSLSTR Aque_aque_SSH.AA SASERSYPSNQLSP----------------------SKRSLTSQEKLNEVGEEEVGGADM Mbre_mbre_SSH-A.AA TRSTSFATTRDLAD-----------------RFATQMEQSVNDCASAPAPPEATTAAAGT Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA ASSATGSTQDDLID-----------SPGTNRKDIDVNRTECGECEKNQQDGENCSVDDAE Nvec_nvec_SSH.AA SSQQLNAETLEALPFIKNTKASKYKANQEPEESKDDFDLDLMLLKVSEDKKKQKLVHQSE Dmel_ssh.AA CQEESQELLLEAVD------------AGQR-RCPSLYRSASSAHSPRQRQPLRCNSE-EL Hsap_SSH3.AA LELESTSETSDMPE-------------------------VFSSHESSHEEPLQPFPQLAR Hsap_SSH1.AA RETPKVLPKSLLLK------------NSHCDKNPPSTEVVIKE-ESSPKKDMKPAKDLRL Hsap_SSH2.AA KNSKNDSSVADLAP------------KGKSDEAPPEHSFVLKEPEMSKGKGKYSGSEAGS Aque_aque_SSH.AA EVGGDKGE---------------------GKEQINPTLITSVTNRIKEIEKMNNRP---- Mbre_mbre_SSH-A.AA TTTTTATATTASPSTAST-----------TVEAQGKSQPSDEQAASPAVQSVQPAPEGKT Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA NASAPMDVTETTGDNNRS-----------SVYTTSGEEI---QLSMGLVERHKREFEQKT Nvec_nvec_SSH.AA SLEGNITTVAPLEDKAELDPADRDDWGEGTVDEIPRPGTVRRNTEL-LLGKSSTKEEAKE Dmel_ssh.AA MHTSDIENKNTTPGDHEAT----------VVLRVQGQTLADDQRISGNVQILKQNFEAKA Hsap_SSH3.AA TKGGQQVDRGPQPALKSRQ----------SVVTLQGSAVVANRTQA--FQEQEQ------ Hsap_SSH1.AA LFSNESEKPTTNSYLMQHQE---------SIIQLQKAGLVRKHTKE--LERLKS-VPADP Hsap_SSH2.AA LSHSEQNATVPAPRVLEFDHLPDPQEGPGSDTGTQQEGVLKDLRTV--IPYQESETQAVP Aque_aque_SSH.AA ------------------SSAGKRSNLSRASSEESLPSCQSRDVHVHVSDVHETTPSPIQ Mbre_mbre_SSH-A.AA LAA---------------GAAGGHELPSRGRTQSSGASVSALRPYRSSQDKSELPKPPRG Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA A-----------------AEVLQQDTETDAAVDDATDLEGAAQSSPGVCEPLEEERMDVQ Nvec_nvec_SSH.AA ELVTVSNVNSDLVHLKSAPSREAVPAQHIVENSGAKVFYFERTVSAEAPSPPGSVKRNKQ Dmel_ssh.AA GVV---------------GTGGGGGGGTAAGSGSSSTIATSVSAVAGACSA--------- Hsap_SSH3.AA ------------------GQGQGQGEPCISSTPRFRKVVRQASVH--------------- Hsap_SSH1.AA AP----------------PSRDGPASRLEASIPEESQ----------------------- Hsap_SSH2.AA LPLPKRVEIIEYTHIVTSPNHTGPGSEIATSEKSGEQGLRKVNMEKSVTVLCTLDENLNR Aque_aque_SSH.AA TEQPIVNESSNTTEVLAKEVVGGADISTCDSPNTRYQRATKAASMLGQKRSALSSPEANN Mbre_mbre_SSH-A.AA FPRQHQEGKSSSSLVALDGSATGAEAKAATTRVSSAPNPQHASTADAVPAVNASPGSSNA Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA EEGGCTSTAYPDEASGWKVGDVRRHTMELEERMELASSPS---------PTKKSVFWQDR Nvec_nvec_SSH.AA IFEGKREQNADENIILPEVPQNEEIEAGVKDEEEETSKEDSVLSPTGAVKKQTQLFEGKG Dmel_ssh.AA --NPGKKTTSHQSLPSSPVAQHANHVSAASNSNSSASNSSDSSVSENCDRNVKGLVHKYQ Hsap_SSH3.AA --DSGEEGEA-------------------------------------------------- Hsap_SSH1.AA --DPAALHELGPLVMP---SQAGSDEKSEAAPASL-----EGGS-----LKSPPPFFYRL Hsap_SSH2.AA TLDPNQV-SLHPQVLPLPHSSSPEHNRPTDHPTSILSSPEDRGSSLSTALETAAPFVSHT Aque_aque_SSH.AA PPTGGGAVNAISDEGAVP------------------------------------------ Mbre_mbre_SSH-A.AA GHSLPRSKSTASVTSIAS------------------------------------------ Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA DGDEQSELTSEELRNIQE------------------------------------------ Nvec_nvec_SSH.AA EFSSGWTKSSKKEPEIIK------------VAVGEREADAMSKEDSLQGPTGAVRRQTKL Dmel_ssh.AA TTTSCSSQAAATPTVACA------------------------------------------ Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA DHTSSFSKDFL--KTICY--------------------------TPTSS----------- Hsap_SSH2.AA THLLSASLDYLHPQTMVHLEGFTEQSSTTDEPSAEQVSWEESQESPLSSGSEVPYKDSQL Aque_aque_SSH.AA -------------------------------QEREGGEGSKGVRELLGVFDKQS------ Mbre_mbre_SSH-A.AA -------------------------------AYAETQEAFEPLRWTSSEVVAWLEQ---- Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA ------MDIPLRSSSPDGVTMEAEAGESEVLVGVAEQVKQLELRRCRSIAKMSNEKVKT- Nvec_nvec_SSH.AA FEGKESLESNFKDEPKSDVSKTSQNDLEVLKAYSSEGEEGSEMTKEESVDTSSVVNVKFH Dmel_ssh.AA --------------------PLPPAGTASNISHSCSTTTTTSFKQRPLSYYDRSLSNRST Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA -------------------------SMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIETR Hsap_SSH2.AA SSADLSLISKLGDNTGELQEKMDPLPVACRLPHSSSSENIKSLSHSPGVVKERAKEIESR Aque_aque_SSH.AA ----STKGGGGELKRTSSL----------------------------------------- Mbre_mbre_SSH-A.AA ----AGLAEYGPLFAREEL-------------QGCDLLDLCNDDLKSIGIMTLHARKRIL Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA LRALIGVGDEKPVSESSS--------------SAEATCKSMADEPLVELNPDTVRLFTSQ Nvec_nvec_SSH.AA LKLLEEIIRSSNAREQHKHRTNKALAAIEEKRSRIDLQRNKKDSGLFQDNKSQVEFEMES Dmel_ssh.AA HDYSDSRPPPAPVRVSHS--------------SNVQHQQQQQQQLQPEQHQQQV------ Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA LRL-AGLTVSSPLKRSHSL-------------AKLGSLTFSTEDLSSEADPSTV------ Hsap_SSH2.AA VVFQAGLTKPSQMRRSASL-------------AKLGYLDLCKDCL-PEREPASCESPHLK Aque_aque_SSH.AA -------------RGSTDVVHLLSHKRGASIGDI-------------------------- Mbre_mbre_SSH-A.AA RACRALTDACAPDADTCMTSAGANTPGASAFGQS-------------------------- Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA IGCEVTLDQKAATGERKTRKSESDKESPSSSGSKIKSQHGP-----------SHPLRKLA Nvec_nvec_SSH.AA LDEDYVFVPDNDEEDDANTSHDDLLDSLSHSAVSLAIENAQKNLDEEETIASSGHVKRRT Dmel_ssh.AA -------------QIRRLAQHGKTH-PLSRLSAPKTG----------------------- Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA ----------ADSQDTTLSESSFLHEPQGTPRDPAAT---------------SKPSGKPA Hsap_SSH2.AA LLQPFL---RTDSGMHAMEDQESLENP-GAPHNPEPTKSFVEQLTTTECIVQSKPVERPL Aque_aque_SSH.AA ------------------------------------------------------------ Mbre_mbre_SSH-A.AA ------------------------------------------------------------ Mbre_mbre_SSH-B.AA ------------------------------------------------------------ Spur_spur_SSH.AA QGGATGRG---------------------------------------------------- Nvec_nvec_SSH.AA LLIEEQLREKGSPVRRHVSLPKSTRPEDRPVVRKRSL----------------------- Dmel_ssh.AA ------------------------------------------------------------ Hsap_SSH3.AA ------------------------------------------------------------ Hsap_SSH1.AA PENLKS-----------------------PSWMSKS------------------------ Hsap_SSH2.AA VQYAKEFGSSQQYLLPRAGLELTSSEGGLPVLQTQGLQCACPAPGLAVAPRQQHGRTHPL Aque_aque_SSH.AA -------------------- Mbre_mbre_SSH-A.AA -------------------- Mbre_mbre_SSH-B.AA -------------------- Spur_spur_SSH.AA -----------TRGKFYSTM Nvec_nvec_SSH.AA -----------SDITVKTRE Dmel_ssh.AA -----------FNTAAYNTM Hsap_SSH3.AA -------------------- Hsap_SSH1.AA -------------------- Hsap_SSH2.AA RRLKKANDKKRTTNPFYNTM