CLUSTAL W (1.81) multiple sequence alignment Scer_TIM50.AA ---------------------MLSILRNSVRLNSRALRVVPSAANTLTSVQASRRLLTSY Mbre_mbre_25683.AA -------------------MAAVRKMAQAAFSTTLRGAG--------------------- Aque_g24807.t1.AA ------------------MTMFSRLLSSFRYSSCSLRRGLTV------------------ Cele_scpl-4.AA ----------MSLSKLTQTCFSRHQAKTFIRLYSSDFKSLLGPPAVANPYADNGRTRFAP Nvec_nvec_122269.AA --------MASVLGARCRSFL-NKVRVNSRILTSPRNRL-------------------IF Hsap_TIMM50.AA ------MASALSLGNKCDPFLRCVLCRGGGALQGPRGRGPDDFE---SQLSPPGSARRLV Spur_spur_hmm146889,hmm241049.AA ---------MPKKRALFWLIVGLLLLVTAWNVARHDFSWPKERP-----------WLRLI Spur_spur_hmm239069,hmm148869.AA ------------------------------------------------------------ Dmel_ttm3.AA ----------------------MHKIVWFGTLNKSIGYI------------GKKKTCLLS Dmel_ttm2.AA -----MSLIAIERVLCGWPKICRKLIVTSRSLTSGLRRALVKQPRKGGDVGKPGMELGRC Dmel_ttm50.AA MSMSMAPATVLQLLRGLSTPRLLTHIHQHRALGNHYHHYHQHYQHQHHLLHHQQQYLRLF Scer_TIM50.AA SSFLQKETKDDKPKSILTDDMLFKAGVDVD------------------------------ Mbre_mbre_25683.AA ---------ARRTLLPARGARRFASTEGDA------------------------------ Aque_g24807.t1.AA ---------RRSVGFNGSLPRRFYYVKPKK------------------------------ Cele_scpl-4.AA IVPINHGNVFASIKLPINETQEAIAFKSEV-----EEAPKVEKLEVESPKIEAEKVLSSP Nvec_nvec_122269.AA NCKTEPL--LPRQYYPLRNQRAFYYVKPKQ------------------------------ Hsap_TIMM50.AA RSKRACG--NPPDAFGLSR-ASVHPPLPRVSIGCSSGPGRAKRERVGGAAWRQRKMAASA Spur_spur_hmm146889,hmm241049.AA VDFYSCGILFQSVVYSYEDDAYIHQFVSNI------------------------------ Spur_spur_hmm239069,hmm148869.AA ------------MPFPSGCDGEKQ------------------------------------ Dmel_ttm3.AA PCEKICL--NSARKTVQRCDKNYSPPKLRR------------------------------ Dmel_ttm2.AA SCFGLRVNLSNASVVYVGHRRYSTYEKTST------------------------------ Dmel_ttm50.AA TCTALPA--AAPALFSILHTARGYSSTTKQ-----------------EAGATGPNDAPEV Scer_TIM50.AA ----EKGQGKNEETSGEGGEDKNEPSSKSEKSRR------------KRQTSTDIKREKY- Mbre_mbre_25683.AA -----------------------------------------------SQSSSEASSMG-- Aque_g24807.t1.AA ------------KASGSGQ----------------------------------------- Cele_scpl-4.AA PPAPAPTSSAIDELNSLKDSLEKLESAASKSSSSSGGSSDNSDPGNAEEIEARRKRMERN Nvec_nvec_122269.AA ---------------------------------------------------KKGPSLK-- Hsap_TIMM50.AA AVFSRLRSGLRLGSRGLCTRLATPPRRAPDQAAEIGSRGSTKAQGPQQQPGSEGPSYAKK Spur_spur_hmm146889,hmm241049.AA ------------------------------------------------------------ Spur_spur_hmm239069,hmm148869.AA ------------------------------------------------------------ Dmel_ttm3.AA -----------------------------------------------------IKNFY-- Dmel_ttm2.AA ----QILTKLFPQTSEESNDEESRERRKLEEEEE------------QKELERAFRRMKL- Dmel_ttm50.AA APNAPLLAKLFPQTSPEVDSNAEQERKKREEEEE-------------KENERAWKRMKL- Scer_TIM50.AA ----ANWF--YIFS-LSALTGTAIY-MARD-WEPQESEELKKDIDNGYTLSLMYKRFKAR Mbre_mbre_25683.AA ----GWVMAAMGIA-GVGAAGVGIYVLGGPTTLEEAQRPM-----NLNEVQNYVTRATKR Aque_g24807.t1.AA ----AILV--LAGV-TLAITGGAIYVLGRP-EDEIIGLQEQDKYAGENPFKAYLLRAKDT Cele_scpl-4.AA TRIGAYVL--FGGS-IIGFI-SFCFYYGRA-QRDEFGNVISDEFSGSFLAPFY--RIANS Nvec_nvec_122269.AA ----GWLL--FGGG-MVGFATAGVIYLGQP-FADEPDKPSRDPYKNELFPLQFIYRARDR Hsap_TIMM50.AA V---ALWL--AGLL-GAGGTVSVVYIFGNN-PVDENGAKIPDEFDNDPILVQQLRRTYKY Spur_spur_hmm146889,hmm241049.AA ----GSSM--FVFETQSLLPQMALQPFGQP-QLDEHGKVIVDEFEDDFIVFGYLKRAYRE Spur_spur_hmm239069,hmm148869.AA ----GTNI--TGTC--------------QP-QLDEHGKVIVDEFEDDFIVFGYLKRAYRE Dmel_ttm3.AA ----TYSV--VLGS-LFSIVMWAIYKLGKP--EEDHRGPIEDEFSQLPWFRQYIMRMWHT Dmel_ttm2.AA ----GFGL--FGIG-SMLFSFWAIYFYGRP-SLDEHGNEVIDEFSCLPQMQQLMWRTWKS Dmel_ttm50.AA ----GFAI--FGGS-AVAAGFWAVYEFGKP-EVDPNGQPIEDEFTHKPLVQQYLQRMWKS . * Scer_TIM50.AA FNSMF-------------------TYFQEPPFPDLLPPPPPPPY-QRPLTLVITLEDFLV Mbre_mbre_25683.AA ARQLY-------------------QDFTDPEPELLLPEPLPPQYRPTDYTIVLDLEDTLL Aque_g24807.t1.AA ILSYK-------------------LKFTEPSSQLLLPEPLPHPY-QRPYTLLIEVKDIFI Cele_scpl-4.AA FKLWR-------------------DYVVEPAREQLLPDPLPAPYLQPKYTIVIELKNILV Nvec_nvec_122269.AA LWDFY-------------------EMFVEPSSTKLLPDPLPEPYIQPPYTLILEMTDVLV Hsap_TIMM50.AA FKDYR-------------------QMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLL Spur_spur_hmm146889,hmm241049.AA MNTYR-------------------TMIAEPSAEKLLPDPLVEPYYQPPYTLVLEMKDILV Spur_spur_hmm239069,hmm148869.AA MNTYRTVSFKQKIIRIRHFISHFVQMIAEPSAEKLLPDPLVEPYYQPPYTLVLEMKDILV Dmel_ttm3.AA LQYYE-------------------KMMEEPQMARLLPNVVPPPYIQPPYSLVLEIKDVLV Dmel_ttm2.AA VNRFQ-------------------RFFKEPSRKKLLPDPLQPPYVQPPYTLVLEIKDVLV Dmel_ttm50.AA IHYYQ-------------------RMIQEPSRAKLLPDPLKPPYVQPRYTLVLEMKDVLV . :* *** * :::: : . :: Scer_TIM50.AA HSEWSQKHGWRTAKRPGADYFLGYLS-QY-YEIVLFSSNYMMYSDKIAEKLDPIHAFVSY Mbre_mbre_25683.AA HSEWTFEHGWRTKKRPFLANFLESCVMELGLELVVFSESQVAEAMLLIDKMDP-KQCIQY Aque_g24807.t1.AA HSDYERNMGWRHQKRPGLDAFLNALF-DY-YEIVVFTSENALSTHPIIDKMDP-NQYIMY Cele_scpl-4.AA HPEWTYKTGYRFLKRPALDYFLDVIGYPN-FEVVIYSSESMMTAAPVVDSFDP-KQRIMY Nvec_nvec_122269.AA HPEYDRKSGWRFRKRPGVEFFLNQLA-PL-FEIVVFTHEVGFSASPVIDGIDP-HQMIMY Hsap_TIMM50.AA HPEWSLATGWRFKKRPGIETLFQQLA-PL-YEIVIFTSETGMTAFPLIDSVDP-HGFISY Spur_spur_hmm146889,hmm241049.AA HPEWTYANGWRFKKRPGVEYFLQQAGPPL-FEIVIYTSEQGFTAFPILDSLDP-KGCIMY Spur_spur_hmm239069,hmm148869.AA HPEWTYANGWRFKKRPGVEYFLQQAGPPL-FEIVIYTSEQGFTAFPILDSLDP-KGCIMY Dmel_ttm3.AA HPDWTYQTGWRFKKRPGVDYFLQQCS-RN-FEIVIYTSEQGMTAFPLLDALDP-YGYIKY Dmel_ttm2.AA HPDWTYETGWRFKKRPGVDVFLKECA-KY-FEIVVYTAEQGVTVFPLVDALDP-NGCIMY Dmel_ttm50.AA HPDWTYQTGWRFKKRPGVDHFLAECA-KD-FEIVVFTAEQGMTVFPILDALDP-NGYIMY *.:: *:* *** :: *:*::: . : : .** : * Scer_TIM50.AA NLFKEHCVYKDGVHIKDLSKLNRDLSKVIIIDTDPNSYKLQPENAIPMEPWNGEA---DD Mbre_mbre_25683.AA RLYKPHMRYVDGEPVKDLDWLNRDLSKVIVIDDKPEQVRKHKDNVLRVRPFKGTPEQAND Aque_g24807.t1.AA RLYRDSTKYISGEHVKDLTHINRSLNRVIMVDTNPLSVKLQPENSIILDKWTGDI---YD Cele_scpl-4.AA KLFRDCTKYMNGHHVKDLSKLNRDLSKVIYIDFDAKSGQLNPENMLRVPEWKGNM---DD Nvec_nvec_122269.AA RLFRDATKYIKGTHVKDLSGINRDLKKVIVIDCNKAATELNERNAIILKKWEGNP---AD Hsap_TIMM50.AA RLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNS---DD Spur_spur_hmm146889,hmm241049.AA RLFRDATKYVNGHHVKDLSSLNRDLSKVIIVDCNAKSYQLQPKNALGLKKWEGND---DD Spur_spur_hmm239069,hmm148869.AA RLFRDATKYVNGHHVKDLSSLNRDLSKVIIVDCNAKSYQLQPKNALGLKKWEGND---DD Dmel_ttm3.AA RLVRGATDLVEGQHTKNLDYLNRDLSRVIVVDCDPYTTPLHPDNSLVLTKWLGND---DD Dmel_ttm2.AA RLVRDSTHFDGGHHVKNLDNLNRDLKRVVVVDWDRNSTKFHPSNSFSIPRWSGND---ND Dmel_ttm50.AA RLVRDATHFVDGHHVKNLDNLNRDLKKVIVVDWDANATKMHPDNTFGLARWHGND---DD .* . * *:: :**. .*: :* . : * . : : * * Scer_TIM50.AA K-LVRLIPFLEYLATQQTKDVRPILNSFEDK-KNLAEEFDHRVKKLK--DKFYGDHKSGG Mbre_mbre_25683.AA RELLDVLTFLANIVQSRVPDVRDVLRSYEGE-ESVAEAFQERQRLLL-----QQQLQHQQ Aque_g24807.t1.AA TSLKDLGAFLLTIAMSNTDDVRPVLDYYKEQGGNLLETFKANQARLR-----EEEEKRMS Cele_scpl-4.AA TSLVDLAELLKTIHLSDAEDVRPMLQYYSQY-DDPAKEFRRRAVYLS-----QQEE---- Nvec_nvec_122269.AA TTLVDLLPLLQTIATSGVDDVRAVLDFYRQE-DDIVAAFKRNQARLR-----EAEQARLQ Hsap_TIMM50.AA RVLLDLSAFLKTIALNGVEDVRTVLEHYALE-DDPLAAFKQRQSRLE-----QEEQQRLA Spur_spur_hmm146889,hmm241049.AA RTLFELAAFLRTVAASGVEDVRTVLEFYQQF-EDPMEAFRINQARLQ--SEQEEEAKRIA Spur_spur_hmm239069,hmm148869.AA RTLFELAAFLRTVAASGVEDVRTVLEFYQQF-EDPMEAFRINQARLQVRSEQEEEAKRIA Dmel_ttm3.AA VQLFDLTAFLQLIAEHQVNDVREVLRYYRQF-EDPMEQFKDNQRRLQ-----EQSQESIQ Dmel_ttm2.AA TTLFELTSFLSVLGTSEIDDVREVLQYYNQF-SDSLSQFRENQRKLG-------ELMHAE Dmel_ttm50.AA GQLLDLIAFLKIIAQNNVDDVREVLHYYRQF-DDPINQFRENQRKLA-------EQMLEA * : :* : *** :* : . * . * . Scer_TIM50.AA NWAMTALGLGNSLGGSTKFPLDLIHEEGQKNYLMFMKMIEEEKEKIRIQQEQMGGQTFTL Mbre_mbre_25683.AA ------------------------------------------------AVNEQNANQPRR Aque_g24807.t1.AA TYSSKGKRFGSTFNVFSFKKSSSSSPAPLEVATAATPADTPFVSPAPLDGGETNKPQTTG Cele_scpl-4.AA ------------------------------------------------QKKQQPDDSSML Nvec_nvec_122269.AA ------------------------------------------------KLEQQNKQ---G Hsap_TIMM50.AA ------------------------------------------------ELSKSNKQNLFL Spur_spur_hmm146889,hmm241049.AA ------------------------------------------------EAKEKGGSSLVG Spur_spur_hmm239069,hmm148869.AA ------------------------------------------------EAKEKGGSSLVG Dmel_ttm3.AA ------------------------------------------------NLPTSERQ---- Dmel_ttm2.AA ------------------------------------------------EVEKTSKSRPVV Dmel_ttm50.AA ------------------------------------------------ERIEQSKTKPMV Scer_TIM50.AA KDYVEGNLPSPEEQMKIQLEKQKEVDALFEEEKKKKKIAESK Mbre_mbre_25683.AA KRF-FGLLG--------------------------------- Aque_g24807.t1.AA GGW-LGWLG------------------------LK------- Cele_scpl-4.AA KRYSGRLFG------------------------SRRHVNA-- Nvec_nvec_122269.AA RSW-GGMFG------------------------R-------- Hsap_TIMM50.AA GSLTSRLWP------------------------RSKQP---- Spur_spur_hmm146889,hmm241049.AA G-WTRGLIG------------------------RR------- Spur_spur_hmm239069,hmm148869.AA G-WTRGLIG------------------------RR------- Dmel_ttm3.AA --WNLTLLG------------------------RSLRGSSIK Dmel_ttm2.AA KNWTRGFIN------------------------H-------- Dmel_ttm50.AA KQWSRNILG------------------------R--------